-- dump date 20140619_091605 -- class Genbank::misc_feature -- table misc_feature_note -- id note 585054000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 585054000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585054000003 putative catalytic residues [active] 585054000004 putative nucleotide binding site [chemical binding]; other site 585054000005 putative aspartate binding site [chemical binding]; other site 585054000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 585054000007 dimer interface [polypeptide binding]; other site 585054000008 putative threonine allosteric regulatory site; other site 585054000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 585054000010 putative threonine allosteric regulatory site; other site 585054000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585054000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585054000013 homoserine kinase; Provisional; Region: PRK01212 585054000014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585054000015 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 585054000016 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 585054000017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054000018 catalytic residue [active] 585054000019 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585054000020 hypothetical protein; Validated; Region: PRK02101 585054000021 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 585054000022 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 585054000023 transaldolase-like protein; Provisional; Region: PTZ00411 585054000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585054000025 active site 585054000026 dimer interface [polypeptide binding]; other site 585054000027 catalytic residue [active] 585054000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585054000029 MPT binding site; other site 585054000030 trimer interface [polypeptide binding]; other site 585054000031 hypothetical protein; Provisional; Region: PRK10659 585054000032 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 585054000033 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 585054000034 nucleotide binding site [chemical binding]; other site 585054000035 NEF interaction site [polypeptide binding]; other site 585054000036 SBD interface [polypeptide binding]; other site 585054000037 chaperone protein DnaJ; Provisional; Region: PRK10767 585054000038 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585054000039 HSP70 interaction site [polypeptide binding]; other site 585054000040 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 585054000041 substrate binding site [polypeptide binding]; other site 585054000042 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585054000043 Zn binding sites [ion binding]; other site 585054000044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585054000045 dimer interface [polypeptide binding]; other site 585054000046 Hok/gef family; Region: HOK_GEF; pfam01848 585054000047 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 585054000048 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 585054000049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054000050 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 585054000051 putative dimerization interface [polypeptide binding]; other site 585054000052 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 585054000053 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 585054000054 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 585054000055 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 585054000056 active site 585054000057 Riboflavin kinase; Region: Flavokinase; smart00904 585054000058 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 585054000059 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585054000060 HIGH motif; other site 585054000061 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585054000062 active site 585054000063 KMSKS motif; other site 585054000064 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 585054000065 tRNA binding surface [nucleotide binding]; other site 585054000066 anticodon binding site; other site 585054000067 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585054000068 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 585054000069 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585054000070 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585054000071 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 585054000072 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 585054000073 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585054000074 active site 585054000075 tetramer interface [polypeptide binding]; other site 585054000076 Protein of unknown function (DUF805); Region: DUF805; pfam05656 585054000077 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 585054000078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054000079 active site 585054000080 phosphorylation site [posttranslational modification] 585054000081 intermolecular recognition site; other site 585054000082 dimerization interface [polypeptide binding]; other site 585054000083 Transcriptional regulator; Region: CitT; pfam12431 585054000084 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 585054000085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054000086 putative active site [active] 585054000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054000088 ATP binding site [chemical binding]; other site 585054000089 Mg2+ binding site [ion binding]; other site 585054000090 G-X-G motif; other site 585054000091 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 585054000092 oxaloacetate decarboxylase; Provisional; Region: PRK14040 585054000093 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 585054000094 active site 585054000095 catalytic residues [active] 585054000096 metal binding site [ion binding]; metal-binding site 585054000097 homodimer binding site [polypeptide binding]; other site 585054000098 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585054000099 carboxyltransferase (CT) interaction site; other site 585054000100 biotinylation site [posttranslational modification]; other site 585054000101 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 585054000102 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 585054000103 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 585054000104 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 585054000105 putative active site [active] 585054000106 (T/H)XGH motif; other site 585054000107 citrate lyase subunit gamma; Provisional; Region: PRK13253 585054000108 citrate lyase, beta subunit; Region: citE; TIGR01588 585054000109 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 585054000110 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 585054000111 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 585054000112 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 585054000113 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 585054000114 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 585054000115 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 585054000116 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 585054000117 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 585054000118 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 585054000119 catalytic site [active] 585054000120 subunit interface [polypeptide binding]; other site 585054000121 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 585054000122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585054000123 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585054000124 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 585054000125 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585054000126 ATP-grasp domain; Region: ATP-grasp_4; cl17255 585054000127 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 585054000128 IMP binding site; other site 585054000129 dimer interface [polypeptide binding]; other site 585054000130 interdomain contacts; other site 585054000131 partial ornithine binding site; other site 585054000132 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 585054000133 carnitine operon protein CaiE; Provisional; Region: PRK13627 585054000134 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585054000135 putative trimer interface [polypeptide binding]; other site 585054000136 putative metal binding site [ion binding]; other site 585054000137 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 585054000138 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054000139 substrate binding site [chemical binding]; other site 585054000140 oxyanion hole (OAH) forming residues; other site 585054000141 trimer interface [polypeptide binding]; other site 585054000142 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 585054000143 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 585054000144 acyl-activating enzyme (AAE) consensus motif; other site 585054000145 putative AMP binding site [chemical binding]; other site 585054000146 putative active site [active] 585054000147 putative CoA binding site [chemical binding]; other site 585054000148 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 585054000149 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585054000150 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 585054000151 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585054000152 active site 585054000153 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 585054000154 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585054000155 Ligand binding site [chemical binding]; other site 585054000156 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585054000157 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 585054000158 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 585054000159 Ligand binding site [chemical binding]; other site 585054000160 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585054000161 putative oxidoreductase FixC; Provisional; Region: PRK10157 585054000162 ferredoxin-like protein FixX; Provisional; Region: PRK15449 585054000163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054000164 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585054000165 putative substrate translocation pore; other site 585054000166 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 585054000167 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 585054000168 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585054000169 TrkA-N domain; Region: TrkA_N; pfam02254 585054000170 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 585054000171 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 585054000172 folate binding site [chemical binding]; other site 585054000173 NADP+ binding site [chemical binding]; other site 585054000174 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 585054000175 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 585054000176 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 585054000177 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 585054000178 active site 585054000179 metal binding site [ion binding]; metal-binding site 585054000180 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 585054000181 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 585054000182 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 585054000183 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 585054000184 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 585054000185 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 585054000186 SurA N-terminal domain; Region: SurA_N; pfam09312 585054000187 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585054000188 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585054000189 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 585054000190 OstA-like protein; Region: OstA; pfam03968 585054000191 Organic solvent tolerance protein; Region: OstA_C; pfam04453 585054000192 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585054000193 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 585054000194 putative metal binding site [ion binding]; other site 585054000195 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585054000196 HSP70 interaction site [polypeptide binding]; other site 585054000197 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585054000198 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585054000199 active site 585054000200 ATP-dependent helicase HepA; Validated; Region: PRK04914 585054000201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054000202 ATP binding site [chemical binding]; other site 585054000203 putative Mg++ binding site [ion binding]; other site 585054000204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054000205 nucleotide binding region [chemical binding]; other site 585054000206 ATP-binding site [chemical binding]; other site 585054000207 DNA polymerase II; Reviewed; Region: PRK05762 585054000208 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 585054000209 active site 585054000210 catalytic site [active] 585054000211 substrate binding site [chemical binding]; other site 585054000212 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 585054000213 active site 585054000214 metal-binding site 585054000215 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585054000216 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585054000217 intersubunit interface [polypeptide binding]; other site 585054000218 active site 585054000219 Zn2+ binding site [ion binding]; other site 585054000220 L-arabinose isomerase; Provisional; Region: PRK02929 585054000221 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 585054000222 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 585054000223 trimer interface [polypeptide binding]; other site 585054000224 putative substrate binding site [chemical binding]; other site 585054000225 putative metal binding site [ion binding]; other site 585054000226 ribulokinase; Provisional; Region: PRK04123 585054000227 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 585054000228 N- and C-terminal domain interface [polypeptide binding]; other site 585054000229 active site 585054000230 MgATP binding site [chemical binding]; other site 585054000231 catalytic site [active] 585054000232 metal binding site [ion binding]; metal-binding site 585054000233 carbohydrate binding site [chemical binding]; other site 585054000234 homodimer interface [polypeptide binding]; other site 585054000235 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 585054000236 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585054000237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054000238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054000239 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585054000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054000241 putative DNA binding site [nucleotide binding]; other site 585054000242 putative Zn2+ binding site [ion binding]; other site 585054000243 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585054000244 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585054000245 substrate binding site [chemical binding]; other site 585054000246 dimer interface [polypeptide binding]; other site 585054000247 ATP binding site [chemical binding]; other site 585054000248 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 585054000249 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 585054000250 inhibitor site; inhibition site 585054000251 active site 585054000252 dimer interface [polypeptide binding]; other site 585054000253 catalytic residue [active] 585054000254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 585054000255 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 585054000256 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585054000257 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585054000258 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 585054000259 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 585054000260 Walker A/P-loop; other site 585054000261 ATP binding site [chemical binding]; other site 585054000262 Q-loop/lid; other site 585054000263 ABC transporter signature motif; other site 585054000264 Walker B; other site 585054000265 D-loop; other site 585054000266 H-loop/switch region; other site 585054000267 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 585054000268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054000269 dimer interface [polypeptide binding]; other site 585054000270 conserved gate region; other site 585054000271 putative PBP binding loops; other site 585054000272 ABC-ATPase subunit interface; other site 585054000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054000274 dimer interface [polypeptide binding]; other site 585054000275 conserved gate region; other site 585054000276 putative PBP binding loops; other site 585054000277 ABC-ATPase subunit interface; other site 585054000278 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 585054000279 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 585054000280 transcriptional regulator SgrR; Provisional; Region: PRK13626 585054000281 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585054000282 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 585054000283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054000284 sugar efflux transporter; Region: 2A0120; TIGR00899 585054000285 putative substrate translocation pore; other site 585054000286 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; carbohydrate transporter, MFS superfamily (fragment) 585054000287 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; carbohydrate transporter, MFS superfamily (fragment) 585054000288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054000289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054000290 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 585054000291 putative dimerization interface [polypeptide binding]; other site 585054000292 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 585054000293 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 585054000294 active site 585054000295 catalytic residue [active] 585054000296 dimer interface [polypeptide binding]; other site 585054000297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054000298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585054000299 putative substrate translocation pore; other site 585054000300 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 585054000301 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585054000302 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585054000303 shikimate binding site; other site 585054000304 NAD(P) binding site [chemical binding]; other site 585054000305 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585054000306 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 585054000307 active site 585054000308 FMN binding site [chemical binding]; other site 585054000309 substrate binding site [chemical binding]; other site 585054000310 putative catalytic residue [active] 585054000311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 585054000312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054000313 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 585054000314 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 585054000315 substrate binding site [chemical binding]; other site 585054000316 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 585054000317 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 585054000318 substrate binding site [chemical binding]; other site 585054000319 ligand binding site [chemical binding]; other site 585054000320 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 585054000321 tartrate dehydrogenase; Region: TTC; TIGR02089 585054000322 2-isopropylmalate synthase; Validated; Region: PRK00915 585054000323 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 585054000324 active site 585054000325 catalytic residues [active] 585054000326 metal binding site [ion binding]; metal-binding site 585054000327 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 585054000328 leu operon leader peptide; Provisional; Region: PRK09925 585054000329 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 585054000330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054000331 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 585054000332 putative substrate binding pocket [chemical binding]; other site 585054000333 putative dimerization interface [polypeptide binding]; other site 585054000334 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 585054000335 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585054000336 PYR/PP interface [polypeptide binding]; other site 585054000337 dimer interface [polypeptide binding]; other site 585054000338 TPP binding site [chemical binding]; other site 585054000339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585054000340 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585054000341 TPP-binding site [chemical binding]; other site 585054000342 dimer interface [polypeptide binding]; other site 585054000343 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 585054000344 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585054000345 putative valine binding site [chemical binding]; other site 585054000346 dimer interface [polypeptide binding]; other site 585054000347 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 585054000348 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 585054000349 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054000350 DNA binding site [nucleotide binding] 585054000351 domain linker motif; other site 585054000352 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 585054000353 dimerization interface [polypeptide binding]; other site 585054000354 ligand binding site [chemical binding]; other site 585054000355 mraZ protein; Region: TIGR00242 585054000356 MraZ protein; Region: MraZ; pfam02381 585054000357 MraZ protein; Region: MraZ; pfam02381 585054000358 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 585054000359 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 585054000360 cell division protein FtsL; Provisional; Region: PRK10772 585054000361 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 585054000362 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585054000363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585054000364 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 585054000365 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585054000366 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585054000367 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585054000368 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 585054000369 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585054000370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585054000371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585054000372 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 585054000373 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 585054000374 Mg++ binding site [ion binding]; other site 585054000375 putative catalytic motif [active] 585054000376 putative substrate binding site [chemical binding]; other site 585054000377 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 585054000378 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585054000379 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585054000380 cell division protein FtsW; Provisional; Region: PRK10774 585054000381 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 585054000382 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 585054000383 active site 585054000384 homodimer interface [polypeptide binding]; other site 585054000385 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 585054000386 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585054000387 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585054000388 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585054000389 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 585054000390 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585054000391 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585054000392 cell division protein FtsQ; Provisional; Region: PRK10775 585054000393 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 585054000394 Cell division protein FtsQ; Region: FtsQ; pfam03799 585054000395 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 585054000396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054000397 Cell division protein FtsA; Region: FtsA; pfam14450 585054000398 cell division protein FtsZ; Validated; Region: PRK09330 585054000399 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 585054000400 nucleotide binding site [chemical binding]; other site 585054000401 SulA interaction site; other site 585054000402 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 585054000403 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 585054000404 SecA regulator SecM; Provisional; Region: PRK02943 585054000405 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 585054000406 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 585054000407 SEC-C motif; Region: SEC-C; pfam02810 585054000408 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585054000409 active site 585054000410 8-oxo-dGMP binding site [chemical binding]; other site 585054000411 nudix motif; other site 585054000412 metal binding site [ion binding]; metal-binding site 585054000413 DNA gyrase inhibitor; Reviewed; Region: PRK00418 585054000414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 585054000415 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 585054000416 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 585054000417 CoA-binding site [chemical binding]; other site 585054000418 ATP-binding [chemical binding]; other site 585054000419 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 585054000420 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585054000421 active site 585054000422 type IV pilin biogenesis protein; Provisional; Region: PRK10573 585054000423 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585054000424 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585054000425 hypothetical protein; Provisional; Region: PRK10436 585054000426 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585054000427 Walker A motif; other site 585054000428 ATP binding site [chemical binding]; other site 585054000429 Walker B motif; other site 585054000430 putative major pilin subunit; Provisional; Region: PRK10574 585054000431 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585054000432 Pilin (bacterial filament); Region: Pilin; pfam00114 585054000433 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 585054000434 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 585054000435 dimerization interface [polypeptide binding]; other site 585054000436 active site 585054000437 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585054000438 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585054000439 amidase catalytic site [active] 585054000440 substrate binding site [chemical binding]; other site 585054000441 Zn binding residues [ion binding]; other site 585054000442 regulatory protein AmpE; Provisional; Region: PRK10987 585054000443 aromatic amino acid transporter; Provisional; Region: PRK10238 585054000444 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585054000445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054000446 DNA-binding site [nucleotide binding]; DNA binding site 585054000447 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054000448 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 585054000449 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 585054000450 dimer interface [polypeptide binding]; other site 585054000451 TPP-binding site [chemical binding]; other site 585054000452 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 585054000453 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585054000454 E3 interaction surface; other site 585054000455 lipoyl attachment site [posttranslational modification]; other site 585054000456 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585054000457 E3 interaction surface; other site 585054000458 lipoyl attachment site [posttranslational modification]; other site 585054000459 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585054000460 E3 interaction surface; other site 585054000461 lipoyl attachment site [posttranslational modification]; other site 585054000462 e3 binding domain; Region: E3_binding; pfam02817 585054000463 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585054000464 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 585054000465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585054000466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054000467 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585054000468 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 585054000469 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 585054000470 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 585054000471 substrate binding site [chemical binding]; other site 585054000472 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 585054000473 substrate binding site [chemical binding]; other site 585054000474 ligand binding site [chemical binding]; other site 585054000475 hypothetical protein; Provisional; Region: PRK05248 585054000476 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 585054000477 spermidine synthase; Provisional; Region: PRK00811 585054000478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054000479 S-adenosylmethionine binding site [chemical binding]; other site 585054000480 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 585054000481 multicopper oxidase; Provisional; Region: PRK10965 585054000482 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585054000483 Multicopper oxidase; Region: Cu-oxidase; pfam00394 585054000484 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585054000485 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 585054000486 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 585054000487 Trp docking motif [polypeptide binding]; other site 585054000488 putative active site [active] 585054000489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054000490 active site 585054000491 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 585054000492 active site clefts [active] 585054000493 zinc binding site [ion binding]; other site 585054000494 dimer interface [polypeptide binding]; other site 585054000495 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585054000496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585054000497 Walker A/P-loop; other site 585054000498 ATP binding site [chemical binding]; other site 585054000499 Q-loop/lid; other site 585054000500 ABC transporter signature motif; other site 585054000501 Walker B; other site 585054000502 D-loop; other site 585054000503 H-loop/switch region; other site 585054000504 inner membrane transport permease; Provisional; Region: PRK15066 585054000505 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585054000506 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585054000507 active pocket/dimerization site; other site 585054000508 active site 585054000509 phosphorylation site [posttranslational modification] 585054000510 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 585054000511 putative active site [active] 585054000512 putative metal binding site [ion binding]; other site 585054000513 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 585054000514 tetramerization interface [polypeptide binding]; other site 585054000515 active site 585054000516 Uncharacterized conserved protein [Function unknown]; Region: COG5464 585054000517 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585054000518 pantoate--beta-alanine ligase; Region: panC; TIGR00018 585054000519 Pantoate-beta-alanine ligase; Region: PanC; cd00560 585054000520 active site 585054000521 ATP-binding site [chemical binding]; other site 585054000522 pantoate-binding site; other site 585054000523 HXXH motif; other site 585054000524 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 585054000525 oligomerization interface [polypeptide binding]; other site 585054000526 active site 585054000527 metal binding site [ion binding]; metal-binding site 585054000528 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 585054000529 putative fimbrial protein StaF; Provisional; Region: PRK15262 585054000530 putative fimbrial protein StaE; Provisional; Region: PRK15263 585054000531 Fimbrial protein; Region: Fimbrial; cl01416 585054000532 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 585054000533 PapC N-terminal domain; Region: PapC_N; pfam13954 585054000534 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054000535 PapC C-terminal domain; Region: PapC_C; pfam13953 585054000536 putative chaperone protein EcpD; Provisional; Region: PRK09926 585054000537 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054000538 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054000539 Fimbrial protein; Region: Fimbrial; cl01416 585054000540 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 585054000541 catalytic center binding site [active] 585054000542 ATP binding site [chemical binding]; other site 585054000543 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 585054000544 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585054000545 active site 585054000546 NTP binding site [chemical binding]; other site 585054000547 metal binding triad [ion binding]; metal-binding site 585054000548 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585054000549 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 585054000550 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 585054000551 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 585054000552 active site 585054000553 nucleotide binding site [chemical binding]; other site 585054000554 HIGH motif; other site 585054000555 KMSKS motif; other site 585054000556 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 585054000557 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 585054000558 2'-5' RNA ligase; Provisional; Region: PRK15124 585054000559 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585054000560 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585054000561 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 585054000562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054000563 ATP binding site [chemical binding]; other site 585054000564 putative Mg++ binding site [ion binding]; other site 585054000565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054000566 nucleotide binding region [chemical binding]; other site 585054000567 ATP-binding site [chemical binding]; other site 585054000568 Helicase associated domain (HA2); Region: HA2; pfam04408 585054000569 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 585054000570 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 585054000571 Transglycosylase; Region: Transgly; pfam00912 585054000572 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585054000573 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 585054000574 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585054000575 N-terminal plug; other site 585054000576 ligand-binding site [chemical binding]; other site 585054000577 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 585054000578 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585054000579 Walker A/P-loop; other site 585054000580 ATP binding site [chemical binding]; other site 585054000581 Q-loop/lid; other site 585054000582 ABC transporter signature motif; other site 585054000583 Walker B; other site 585054000584 D-loop; other site 585054000585 H-loop/switch region; other site 585054000586 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585054000587 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 585054000588 siderophore binding site; other site 585054000589 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585054000590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585054000591 ABC-ATPase subunit interface; other site 585054000592 dimer interface [polypeptide binding]; other site 585054000593 putative PBP binding regions; other site 585054000594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585054000595 ABC-ATPase subunit interface; other site 585054000596 dimer interface [polypeptide binding]; other site 585054000597 putative PBP binding regions; other site 585054000598 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 585054000599 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585054000600 inhibitor-cofactor binding pocket; inhibition site 585054000601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054000602 catalytic residue [active] 585054000603 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585054000604 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 585054000605 Cl- selectivity filter; other site 585054000606 Cl- binding residues [ion binding]; other site 585054000607 pore gating glutamate residue; other site 585054000608 dimer interface [polypeptide binding]; other site 585054000609 H+/Cl- coupling transport residue; other site 585054000610 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 585054000611 hypothetical protein; Provisional; Region: PRK10578 585054000612 UPF0126 domain; Region: UPF0126; pfam03458 585054000613 UPF0126 domain; Region: UPF0126; pfam03458 585054000614 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 585054000615 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 585054000616 cobalamin binding residues [chemical binding]; other site 585054000617 putative BtuC binding residues; other site 585054000618 dimer interface [polypeptide binding]; other site 585054000619 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 585054000620 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 585054000621 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 585054000622 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054000623 Zn2+ binding site [ion binding]; other site 585054000624 Mg2+ binding site [ion binding]; other site 585054000625 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 585054000626 serine endoprotease; Provisional; Region: PRK10942 585054000627 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585054000628 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585054000629 protein binding site [polypeptide binding]; other site 585054000630 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585054000631 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 585054000632 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 585054000633 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 585054000634 hypothetical protein; Provisional; Region: PRK13677 585054000635 phosphodiesterase YaeI; Provisional; Region: PRK11340 585054000636 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 585054000637 putative active site [active] 585054000638 putative metal binding site [ion binding]; other site 585054000639 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 585054000640 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 585054000641 trimer interface [polypeptide binding]; other site 585054000642 active site 585054000643 substrate binding site [chemical binding]; other site 585054000644 CoA binding site [chemical binding]; other site 585054000645 PII uridylyl-transferase; Provisional; Region: PRK05007 585054000646 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585054000647 metal binding triad; other site 585054000648 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585054000649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054000650 Zn2+ binding site [ion binding]; other site 585054000651 Mg2+ binding site [ion binding]; other site 585054000652 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 585054000653 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 585054000654 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 585054000655 active site 585054000656 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 585054000657 rRNA interaction site [nucleotide binding]; other site 585054000658 S8 interaction site; other site 585054000659 putative laminin-1 binding site; other site 585054000660 elongation factor Ts; Provisional; Region: tsf; PRK09377 585054000661 UBA/TS-N domain; Region: UBA; pfam00627 585054000662 Elongation factor TS; Region: EF_TS; pfam00889 585054000663 Elongation factor TS; Region: EF_TS; pfam00889 585054000664 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 585054000665 putative nucleotide binding site [chemical binding]; other site 585054000666 uridine monophosphate binding site [chemical binding]; other site 585054000667 homohexameric interface [polypeptide binding]; other site 585054000668 ribosome recycling factor; Reviewed; Region: frr; PRK00083 585054000669 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 585054000670 hinge region; other site 585054000671 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 585054000672 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 585054000673 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 585054000674 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 585054000675 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 585054000676 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 585054000677 catalytic residue [active] 585054000678 putative FPP diphosphate binding site; other site 585054000679 putative FPP binding hydrophobic cleft; other site 585054000680 dimer interface [polypeptide binding]; other site 585054000681 putative IPP diphosphate binding site; other site 585054000682 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 585054000683 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585054000684 zinc metallopeptidase RseP; Provisional; Region: PRK10779 585054000685 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585054000686 active site 585054000687 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 585054000688 protein binding site [polypeptide binding]; other site 585054000689 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585054000690 putative substrate binding region [chemical binding]; other site 585054000691 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 585054000692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585054000693 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585054000694 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585054000695 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585054000696 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585054000697 Surface antigen; Region: Bac_surface_Ag; pfam01103 585054000698 periplasmic chaperone; Provisional; Region: PRK10780 585054000699 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 585054000700 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 585054000701 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 585054000702 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 585054000703 trimer interface [polypeptide binding]; other site 585054000704 active site 585054000705 UDP-GlcNAc binding site [chemical binding]; other site 585054000706 lipid binding site [chemical binding]; lipid-binding site 585054000707 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 585054000708 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 585054000709 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 585054000710 active site 585054000711 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 585054000712 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 585054000713 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 585054000714 RNA/DNA hybrid binding site [nucleotide binding]; other site 585054000715 active site 585054000716 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 585054000717 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 585054000718 putative active site [active] 585054000719 putative PHP Thumb interface [polypeptide binding]; other site 585054000720 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 585054000721 generic binding surface II; other site 585054000722 generic binding surface I; other site 585054000723 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 585054000724 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 585054000725 lysine decarboxylase LdcC; Provisional; Region: PRK15399 585054000726 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585054000727 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585054000728 homodimer interface [polypeptide binding]; other site 585054000729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054000730 catalytic residue [active] 585054000731 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585054000732 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 585054000733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585054000734 putative metal binding site [ion binding]; other site 585054000735 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 585054000736 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 585054000737 Ligand Binding Site [chemical binding]; other site 585054000738 TilS substrate binding domain; Region: TilS; pfam09179 585054000739 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 585054000740 Rho-binding antiterminator; Provisional; Region: PRK11625 585054000741 hypothetical protein; Provisional; Region: PRK04964 585054000742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 585054000743 hypothetical protein; Provisional; Region: PRK09256 585054000744 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585054000745 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 585054000746 NlpE N-terminal domain; Region: NlpE; pfam04170 585054000747 hypothetical protein; Provisional; Region: PRK11479 585054000748 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 585054000749 prolyl-tRNA synthetase; Provisional; Region: PRK09194 585054000750 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 585054000751 dimer interface [polypeptide binding]; other site 585054000752 motif 1; other site 585054000753 active site 585054000754 motif 2; other site 585054000755 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 585054000756 putative deacylase active site [active] 585054000757 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585054000758 active site 585054000759 motif 3; other site 585054000760 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 585054000761 anticodon binding site; other site 585054000762 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 585054000763 homodimer interaction site [polypeptide binding]; other site 585054000764 cofactor binding site; other site 585054000765 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 585054000766 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 585054000767 lipoprotein, YaeC family; Region: TIGR00363 585054000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054000769 dimer interface [polypeptide binding]; other site 585054000770 conserved gate region; other site 585054000771 ABC-ATPase subunit interface; other site 585054000772 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 585054000773 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 585054000774 Walker A/P-loop; other site 585054000775 ATP binding site [chemical binding]; other site 585054000776 Q-loop/lid; other site 585054000777 ABC transporter signature motif; other site 585054000778 Walker B; other site 585054000779 D-loop; other site 585054000780 H-loop/switch region; other site 585054000781 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 585054000782 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 585054000783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054000784 active site 585054000785 motif I; other site 585054000786 motif II; other site 585054000787 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054000788 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054000789 active site 585054000790 catalytic tetrad [active] 585054000791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054000792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054000793 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 585054000794 putative effector binding pocket; other site 585054000795 dimerization interface [polypeptide binding]; other site 585054000796 hypothetical protein; Provisional; Region: PRK05421 585054000797 putative catalytic site [active] 585054000798 putative metal binding site [ion binding]; other site 585054000799 putative phosphate binding site [ion binding]; other site 585054000800 putative catalytic site [active] 585054000801 putative phosphate binding site [ion binding]; other site 585054000802 putative metal binding site [ion binding]; other site 585054000803 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585054000804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054000805 S-adenosylmethionine binding site [chemical binding]; other site 585054000806 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 585054000807 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054000808 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054000809 catalytic residue [active] 585054000810 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054000811 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054000812 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 585054000813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054000814 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 585054000815 RNA/DNA hybrid binding site [nucleotide binding]; other site 585054000816 active site 585054000817 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 585054000818 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 585054000819 active site 585054000820 catalytic site [active] 585054000821 substrate binding site [chemical binding]; other site 585054000822 C-N hydrolase family amidase; Provisional; Region: PRK10438 585054000823 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 585054000824 putative active site [active] 585054000825 catalytic triad [active] 585054000826 dimer interface [polypeptide binding]; other site 585054000827 multimer interface [polypeptide binding]; other site 585054000828 C-lysozyme inhibitor; Provisional; Region: PRK09993 585054000829 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 585054000830 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 585054000831 active site 585054000832 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 585054000833 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585054000834 dimer interface [polypeptide binding]; other site 585054000835 active site 585054000836 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 585054000837 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 585054000838 putative active site [active] 585054000839 putative dimer interface [polypeptide binding]; other site 585054000840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 585054000841 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054000842 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585054000843 NlpC/P60 family; Region: NLPC_P60; pfam00877 585054000844 N-acetylglutamate synthase; Validated; Region: PRK05279 585054000845 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 585054000846 putative feedback inhibition sensing region; other site 585054000847 putative nucleotide binding site [chemical binding]; other site 585054000848 putative substrate binding site [chemical binding]; other site 585054000849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054000850 Coenzyme A binding pocket [chemical binding]; other site 585054000851 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 585054000852 AMIN domain; Region: AMIN; pfam11741 585054000853 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585054000854 active site 585054000855 metal binding site [ion binding]; metal-binding site 585054000856 murein transglycosylase A; Provisional; Region: mltA; PRK11162 585054000857 MltA specific insert domain; Region: MltA; pfam03562 585054000858 3D domain; Region: 3D; pfam06725 585054000859 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 585054000860 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 585054000861 putative ATP binding site [chemical binding]; other site 585054000862 putative substrate interface [chemical binding]; other site 585054000863 CsdA-binding activator; Provisional; Region: PRK15019 585054000864 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585054000865 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585054000866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585054000867 catalytic residue [active] 585054000868 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585054000869 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 585054000870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054000871 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585054000872 dimerization interface [polypeptide binding]; other site 585054000873 substrate binding pocket [chemical binding]; other site 585054000874 hypothetical protein; Provisional; Region: PRK10873 585054000875 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 585054000876 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 585054000877 flap endonuclease-like protein; Provisional; Region: PRK09482 585054000878 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585054000879 active site 585054000880 metal binding site 1 [ion binding]; metal-binding site 585054000881 putative 5' ssDNA interaction site; other site 585054000882 metal binding site 3; metal-binding site 585054000883 metal binding site 2 [ion binding]; metal-binding site 585054000884 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585054000885 putative DNA binding site [nucleotide binding]; other site 585054000886 putative metal binding site [ion binding]; other site 585054000887 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 585054000888 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585054000889 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585054000890 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585054000891 serine transporter; Region: stp; TIGR00814 585054000892 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 585054000893 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 585054000894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 585054000895 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 585054000896 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 585054000897 SecY interacting protein Syd; Provisional; Region: PRK04968 585054000898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 585054000899 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585054000900 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 585054000901 probable active site [active] 585054000902 flavodoxin; Provisional; Region: PRK08105 585054000903 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 585054000904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 585054000905 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 585054000906 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 585054000907 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585054000908 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585054000909 active site 585054000910 tetramer interface [polypeptide binding]; other site 585054000911 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585054000912 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585054000913 active site 585054000914 tetramer interface [polypeptide binding]; other site 585054000915 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 585054000916 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 585054000917 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 585054000918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054000919 dimerization interface [polypeptide binding]; other site 585054000920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054000921 dimer interface [polypeptide binding]; other site 585054000922 phosphorylation site [posttranslational modification] 585054000923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054000924 ATP binding site [chemical binding]; other site 585054000925 Mg2+ binding site [ion binding]; other site 585054000926 G-X-G motif; other site 585054000927 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 585054000928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054000929 active site 585054000930 phosphorylation site [posttranslational modification] 585054000931 intermolecular recognition site; other site 585054000932 dimerization interface [polypeptide binding]; other site 585054000933 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585054000934 putative binding surface; other site 585054000935 active site 585054000936 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 585054000937 TRAM domain; Region: TRAM; pfam01938 585054000938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054000939 S-adenosylmethionine binding site [chemical binding]; other site 585054000940 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 585054000941 HD domain; Region: HD_4; pfam13328 585054000942 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585054000943 synthetase active site [active] 585054000944 NTP binding site [chemical binding]; other site 585054000945 metal binding site [ion binding]; metal-binding site 585054000946 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585054000947 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585054000948 antitoxin MazE; Provisional; Region: PRK09798 585054000949 toxin MazF; Provisional; Region: PRK09907 585054000950 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 585054000951 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 585054000952 homodimer interface [polypeptide binding]; other site 585054000953 metal binding site [ion binding]; metal-binding site 585054000954 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 585054000955 homodimer interface [polypeptide binding]; other site 585054000956 active site 585054000957 putative chemical substrate binding site [chemical binding]; other site 585054000958 metal binding site [ion binding]; metal-binding site 585054000959 CTP synthetase; Validated; Region: pyrG; PRK05380 585054000960 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 585054000961 Catalytic site [active] 585054000962 active site 585054000963 UTP binding site [chemical binding]; other site 585054000964 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 585054000965 active site 585054000966 putative oxyanion hole; other site 585054000967 catalytic triad [active] 585054000968 enolase; Provisional; Region: eno; PRK00077 585054000969 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 585054000970 dimer interface [polypeptide binding]; other site 585054000971 metal binding site [ion binding]; metal-binding site 585054000972 substrate binding pocket [chemical binding]; other site 585054000973 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585054000974 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 585054000975 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054000976 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585054000977 Repair protein; Region: Repair_PSII; pfam04536 585054000978 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585054000979 Repair protein; Region: Repair_PSII; pfam04536 585054000980 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585054000981 Repair protein; Region: Repair_PSII; pfam04536 585054000982 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 585054000983 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 585054000984 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 585054000985 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 585054000986 homohexamer interface [polypeptide binding]; other site 585054000987 putative substrate stabilizing pore; other site 585054000988 pterin binding site; other site 585054000989 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 585054000990 Flavodoxin; Region: Flavodoxin_1; pfam00258 585054000991 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 585054000992 FAD binding pocket [chemical binding]; other site 585054000993 FAD binding motif [chemical binding]; other site 585054000994 catalytic residues [active] 585054000995 NAD binding pocket [chemical binding]; other site 585054000996 phosphate binding motif [ion binding]; other site 585054000997 beta-alpha-beta structure motif; other site 585054000998 sulfite reductase subunit beta; Provisional; Region: PRK13504 585054000999 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585054001000 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585054001001 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 585054001002 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585054001003 Active Sites [active] 585054001004 helicase Cas3; Provisional; Region: PRK09694 585054001005 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 585054001006 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 585054001007 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 585054001008 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 585054001009 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 585054001010 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 585054001011 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 585054001012 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 585054001013 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 585054001014 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 585054001015 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 585054001016 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 585054001017 metal binding site [ion binding]; metal-binding site 585054001018 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 585054001019 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585054001020 Active Sites [active] 585054001021 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 585054001022 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 585054001023 CysD dimerization site [polypeptide binding]; other site 585054001024 G1 box; other site 585054001025 putative GEF interaction site [polypeptide binding]; other site 585054001026 GTP/Mg2+ binding site [chemical binding]; other site 585054001027 Switch I region; other site 585054001028 G2 box; other site 585054001029 G3 box; other site 585054001030 Switch II region; other site 585054001031 G4 box; other site 585054001032 G5 box; other site 585054001033 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 585054001034 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 585054001035 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 585054001036 ligand-binding site [chemical binding]; other site 585054001037 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 585054001038 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 585054001039 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 585054001040 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 585054001041 substrate binding site; other site 585054001042 dimer interface; other site 585054001043 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 585054001044 homotrimer interaction site [polypeptide binding]; other site 585054001045 zinc binding site [ion binding]; other site 585054001046 CDP-binding sites; other site 585054001047 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 585054001048 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 585054001049 Permutation of conserved domain; other site 585054001050 active site 585054001051 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 585054001052 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 585054001053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054001054 S-adenosylmethionine binding site [chemical binding]; other site 585054001055 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 585054001056 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054001057 Peptidase family M23; Region: Peptidase_M23; pfam01551 585054001058 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 585054001059 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585054001060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585054001061 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585054001062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585054001063 DNA binding residues [nucleotide binding] 585054001064 MarR family; Region: MarR_2; cl17246 585054001065 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585054001066 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 585054001067 Flavoprotein; Region: Flavoprotein; pfam02441 585054001068 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 585054001069 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 585054001070 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585054001071 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585054001072 active site 585054001073 metal binding site [ion binding]; metal-binding site 585054001074 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 585054001075 MutS domain I; Region: MutS_I; pfam01624 585054001076 MutS domain II; Region: MutS_II; pfam05188 585054001077 MutS domain III; Region: MutS_III; pfam05192 585054001078 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 585054001079 Walker A/P-loop; other site 585054001080 ATP binding site [chemical binding]; other site 585054001081 Q-loop/lid; other site 585054001082 ABC transporter signature motif; other site 585054001083 Walker B; other site 585054001084 D-loop; other site 585054001085 H-loop/switch region; other site 585054001086 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585054001087 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585054001088 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585054001089 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 585054001090 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585054001091 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 585054001092 putative N- and C-terminal domain interface [polypeptide binding]; other site 585054001093 putative active site [active] 585054001094 MgATP binding site [chemical binding]; other site 585054001095 catalytic site [active] 585054001096 metal binding site [ion binding]; metal-binding site 585054001097 putative xylulose binding site [chemical binding]; other site 585054001098 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 585054001099 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585054001100 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585054001101 Walker A/P-loop; other site 585054001102 ATP binding site [chemical binding]; other site 585054001103 Q-loop/lid; other site 585054001104 ABC transporter signature motif; other site 585054001105 Walker B; other site 585054001106 D-loop; other site 585054001107 H-loop/switch region; other site 585054001108 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054001109 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054001110 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054001111 TM-ABC transporter signature motif; other site 585054001112 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 585054001113 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585054001114 ligand binding site [chemical binding]; other site 585054001115 dimerization interface [polypeptide binding]; other site 585054001116 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585054001117 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 585054001118 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585054001119 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 585054001120 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585054001121 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 585054001122 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 585054001123 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585054001124 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585054001125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054001126 Walker A motif; other site 585054001127 ATP binding site [chemical binding]; other site 585054001128 Walker B motif; other site 585054001129 arginine finger; other site 585054001130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054001131 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 585054001132 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 585054001133 dimerization interface [polypeptide binding]; other site 585054001134 ATP binding site [chemical binding]; other site 585054001135 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 585054001136 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 585054001137 hydrogenase assembly chaperone; Provisional; Region: PRK10409 585054001138 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 585054001139 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 585054001140 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 585054001141 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 585054001142 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585054001143 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 585054001144 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054001145 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585054001146 NADH dehydrogenase; Region: NADHdh; cl00469 585054001147 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585054001148 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585054001149 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585054001150 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 585054001151 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585054001152 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585054001153 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585054001154 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 585054001155 nickel binding site [ion binding]; other site 585054001156 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 585054001157 beta-galactosidase; Region: BGL; TIGR03356 585054001158 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 585054001159 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054001160 active site turn [active] 585054001161 phosphorylation site [posttranslational modification] 585054001162 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585054001163 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054001164 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054001165 DNA binding site [nucleotide binding] 585054001166 domain linker motif; other site 585054001167 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585054001168 dimerization interface (closed form) [polypeptide binding]; other site 585054001169 ligand binding site [chemical binding]; other site 585054001170 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 585054001171 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585054001172 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 585054001173 Acylphosphatase; Region: Acylphosphatase; pfam00708 585054001174 HypF finger; Region: zf-HYPF; pfam07503 585054001175 HypF finger; Region: zf-HYPF; pfam07503 585054001176 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 585054001177 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 585054001178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054001179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054001180 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 585054001181 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585054001182 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 585054001183 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 585054001184 iron binding site [ion binding]; other site 585054001185 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 585054001186 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585054001187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054001188 Walker A motif; other site 585054001189 ATP binding site [chemical binding]; other site 585054001190 Walker B motif; other site 585054001191 arginine finger; other site 585054001192 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 585054001193 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585054001194 putative active site [active] 585054001195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585054001196 Transglycosylase SLT domain; Region: SLT_2; pfam13406 585054001197 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054001198 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054001199 hypothetical protein; Validated; Region: PRK03661 585054001200 recombinase A; Provisional; Region: recA; PRK09354 585054001201 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 585054001202 hexamer interface [polypeptide binding]; other site 585054001203 Walker A motif; other site 585054001204 ATP binding site [chemical binding]; other site 585054001205 Walker B motif; other site 585054001206 recombination regulator RecX; Reviewed; Region: recX; PRK00117 585054001207 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 585054001208 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 585054001209 motif 1; other site 585054001210 active site 585054001211 motif 2; other site 585054001212 motif 3; other site 585054001213 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 585054001214 DHHA1 domain; Region: DHHA1; pfam02272 585054001215 carbon storage regulator; Provisional; Region: PRK01712 585054001216 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 585054001217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054001218 motif II; other site 585054001219 Predicted membrane protein [Function unknown]; Region: COG1238 585054001220 glutamate--cysteine ligase; Provisional; Region: PRK02107 585054001221 S-ribosylhomocysteinase; Provisional; Region: PRK02260 585054001222 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054001223 Zn2+ binding site [ion binding]; other site 585054001224 Mg2+ binding site [ion binding]; other site 585054001225 AAA domain; Region: AAA_33; pfam13671 585054001226 RNA ligase; Region: RNA_ligase; pfam09414 585054001227 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585054001228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001229 putative substrate translocation pore; other site 585054001230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001231 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 585054001232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054001233 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054001234 transcriptional repressor MprA; Provisional; Region: PRK10870 585054001235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585054001236 putative L-valine exporter; Provisional; Region: PRK10408 585054001237 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 585054001238 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585054001239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001240 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 585054001241 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585054001242 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 585054001243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054001244 dimer interface [polypeptide binding]; other site 585054001245 conserved gate region; other site 585054001246 putative PBP binding loops; other site 585054001247 ABC-ATPase subunit interface; other site 585054001248 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 585054001249 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 585054001250 Walker A/P-loop; other site 585054001251 ATP binding site [chemical binding]; other site 585054001252 Q-loop/lid; other site 585054001253 ABC transporter signature motif; other site 585054001254 Walker B; other site 585054001255 D-loop; other site 585054001256 H-loop/switch region; other site 585054001257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 585054001258 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 585054001259 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585054001260 dimer interface [polypeptide binding]; other site 585054001261 putative radical transfer pathway; other site 585054001262 diiron center [ion binding]; other site 585054001263 tyrosyl radical; other site 585054001264 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 585054001265 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 585054001266 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585054001267 active site 585054001268 dimer interface [polypeptide binding]; other site 585054001269 catalytic residues [active] 585054001270 effector binding site; other site 585054001271 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585054001272 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 585054001273 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 585054001274 catalytic residues [active] 585054001275 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585054001276 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585054001277 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585054001278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054001279 DNA-binding site [nucleotide binding]; DNA binding site 585054001280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054001281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054001282 homodimer interface [polypeptide binding]; other site 585054001283 catalytic residue [active] 585054001284 hypothetical protein; Provisional; Region: PRK10132 585054001285 hypothetical protein; Provisional; Region: PRK10556 585054001286 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 585054001287 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 585054001288 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585054001289 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 585054001290 active site residue [active] 585054001291 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 585054001292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054001293 dimerization interface [polypeptide binding]; other site 585054001294 putative DNA binding site [nucleotide binding]; other site 585054001295 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585054001296 putative Zn2+ binding site [ion binding]; other site 585054001297 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 585054001298 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 585054001299 bacterial OsmY and nodulation domain; Region: BON; smart00749 585054001300 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054001301 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 585054001302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054001303 DNA-binding site [nucleotide binding]; DNA binding site 585054001304 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054001305 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 585054001306 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 585054001307 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585054001308 inhibitor-cofactor binding pocket; inhibition site 585054001309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054001310 catalytic residue [active] 585054001311 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 585054001312 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 585054001313 tetramerization interface [polypeptide binding]; other site 585054001314 NAD(P) binding site [chemical binding]; other site 585054001315 catalytic residues [active] 585054001316 Predicted dehydrogenase [General function prediction only]; Region: COG0579 585054001317 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585054001318 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 585054001319 substrate binding pocket [chemical binding]; other site 585054001320 active site 585054001321 iron coordination sites [ion binding]; other site 585054001322 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585054001323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054001324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054001325 dimerization interface [polypeptide binding]; other site 585054001326 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585054001327 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585054001328 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 585054001329 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 585054001330 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585054001331 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585054001332 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 585054001333 CoA binding domain; Region: CoA_binding; pfam02629 585054001334 CoA-ligase; Region: Ligase_CoA; pfam00549 585054001335 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585054001336 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585054001337 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585054001338 putative substrate binding site [chemical binding]; other site 585054001339 nucleotide binding site [chemical binding]; other site 585054001340 nucleotide binding site [chemical binding]; other site 585054001341 homodimer interface [polypeptide binding]; other site 585054001342 putative deaminase; Validated; Region: PRK06846 585054001343 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585054001344 active site 585054001345 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585054001346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054001347 S-adenosylmethionine binding site [chemical binding]; other site 585054001348 hypothetical protein; Provisional; Region: PRK13687 585054001349 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of oxidoreductase, Zn-dependent and NAD(P)-binding (part 1) 585054001350 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of oxidoreductase, Zn-dependent and NAD(P)-binding (part 2) 585054001351 transaldolase-like protein; Provisional; Region: PTZ00411 585054001352 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585054001353 active site 585054001354 dimer interface [polypeptide binding]; other site 585054001355 catalytic residue [active] 585054001356 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 585054001357 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 585054001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001359 putative substrate translocation pore; other site 585054001360 dihydroxyacetone kinase; Provisional; Region: PRK14479 585054001361 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 585054001362 DAK2 domain; Region: Dak2; pfam02734 585054001363 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 585054001364 substrate binding site [chemical binding]; other site 585054001365 dimer interface [polypeptide binding]; other site 585054001366 catalytic triad [active] 585054001367 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585054001368 prephenate dehydrogenase; Provisional; Region: PRK08655 585054001369 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585054001370 Helix-turn-helix domain; Region: HTH_28; pfam13518 585054001371 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585054001372 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 585054001373 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 585054001374 DinI-like family; Region: DinI; cl11630 585054001375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 585054001376 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 585054001377 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 585054001378 active site 585054001379 metal binding site [ion binding]; metal-binding site 585054001380 interdomain interaction site; other site 585054001381 D5 N terminal like; Region: D5_N; smart00885 585054001382 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 585054001383 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 585054001384 Ash protein family; Region: Phage_ASH; pfam10554 585054001385 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 585054001386 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 585054001387 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 585054001388 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 585054001389 AAA domain; Region: AAA_22; pfam13401 585054001390 integrase; Provisional; Region: PRK09692 585054001391 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585054001392 active site 585054001393 Int/Topo IB signature motif; other site 585054001394 similar to hypothetical protein; Evidence 5 : No homology to any previously reported sequences 585054001395 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 585054001396 SmpB-tmRNA interface; other site 585054001397 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 585054001398 putative coenzyme Q binding site [chemical binding]; other site 585054001399 hypothetical protein; Validated; Region: PRK01777 585054001400 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 585054001401 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 585054001402 recombination and repair protein; Provisional; Region: PRK10869 585054001403 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585054001404 Walker A/P-loop; other site 585054001405 ATP binding site [chemical binding]; other site 585054001406 Q-loop/lid; other site 585054001407 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585054001408 Q-loop/lid; other site 585054001409 ABC transporter signature motif; other site 585054001410 Walker B; other site 585054001411 D-loop; other site 585054001412 H-loop/switch region; other site 585054001413 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 585054001414 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 585054001415 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 585054001416 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 585054001417 dimer interface [polypeptide binding]; other site 585054001418 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 585054001419 hypothetical protein; Provisional; Region: PRK11573 585054001420 Domain of unknown function DUF21; Region: DUF21; pfam01595 585054001421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585054001422 Transporter associated domain; Region: CorC_HlyC; smart01091 585054001423 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 585054001424 signal recognition particle protein; Provisional; Region: PRK10867 585054001425 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 585054001426 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585054001427 P loop; other site 585054001428 GTP binding site [chemical binding]; other site 585054001429 Signal peptide binding domain; Region: SRP_SPB; pfam02978 585054001430 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 585054001431 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 585054001432 RimM N-terminal domain; Region: RimM; pfam01782 585054001433 PRC-barrel domain; Region: PRC; pfam05239 585054001434 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 585054001435 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 585054001436 lipoprotein; Provisional; Region: PRK11443 585054001437 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 585054001438 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 585054001439 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585054001440 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 585054001441 Chorismate mutase type II; Region: CM_2; cl00693 585054001442 prephenate dehydrogenase; Validated; Region: PRK08507 585054001443 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 585054001444 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 585054001445 Prephenate dehydratase; Region: PDT; pfam00800 585054001446 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 585054001447 putative L-Phe binding site [chemical binding]; other site 585054001448 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585054001449 30S subunit binding site; other site 585054001450 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 585054001451 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 585054001452 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 585054001453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054001454 RNA binding surface [nucleotide binding]; other site 585054001455 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585054001456 active site 585054001457 hypothetical protein; Provisional; Region: PRK10723 585054001458 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 585054001459 protein disaggregation chaperone; Provisional; Region: PRK10865 585054001460 Clp amino terminal domain; Region: Clp_N; pfam02861 585054001461 Clp amino terminal domain; Region: Clp_N; pfam02861 585054001462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054001463 Walker A motif; other site 585054001464 ATP binding site [chemical binding]; other site 585054001465 Walker B motif; other site 585054001466 arginine finger; other site 585054001467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054001468 Walker A motif; other site 585054001469 ATP binding site [chemical binding]; other site 585054001470 Walker B motif; other site 585054001471 arginine finger; other site 585054001472 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585054001473 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 585054001474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001475 putative substrate translocation pore; other site 585054001476 lipoprotein; Provisional; Region: PRK10759 585054001477 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 585054001478 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 585054001479 domain interface [polypeptide binding]; other site 585054001480 putative active site [active] 585054001481 catalytic site [active] 585054001482 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 585054001483 domain interface [polypeptide binding]; other site 585054001484 putative active site [active] 585054001485 catalytic site [active] 585054001486 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 585054001487 CoA binding domain; Region: CoA_binding_2; pfam13380 585054001488 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 585054001489 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 585054001490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585054001491 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585054001492 Uncharacterized conserved protein [Function unknown]; Region: COG3148 585054001493 thioredoxin 2; Provisional; Region: PRK10996 585054001494 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 585054001495 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585054001496 catalytic residues [active] 585054001497 putative methyltransferase; Provisional; Region: PRK10864 585054001498 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 585054001499 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585054001500 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 585054001501 ligand binding site [chemical binding]; other site 585054001502 active site 585054001503 UGI interface [polypeptide binding]; other site 585054001504 catalytic site [active] 585054001505 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 585054001506 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of DNA-binding transcriptional regulator (partial) 585054001507 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 585054001508 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585054001509 ATP binding site [chemical binding]; other site 585054001510 Mg++ binding site [ion binding]; other site 585054001511 motif III; other site 585054001512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054001513 nucleotide binding region [chemical binding]; other site 585054001514 ATP-binding site [chemical binding]; other site 585054001515 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 585054001516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054001517 S-adenosylmethionine binding site [chemical binding]; other site 585054001518 L-aspartate oxidase; Provisional; Region: PRK09077 585054001519 L-aspartate oxidase; Provisional; Region: PRK06175 585054001520 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585054001521 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 585054001522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585054001523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585054001524 DNA binding residues [nucleotide binding] 585054001525 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 585054001526 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 585054001527 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 585054001528 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 585054001529 anti-sigma E factor; Provisional; Region: rseB; PRK09455 585054001530 SoxR reducing system protein RseC; Provisional; Region: PRK10862 585054001531 GTP-binding protein LepA; Provisional; Region: PRK05433 585054001532 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 585054001533 G1 box; other site 585054001534 putative GEF interaction site [polypeptide binding]; other site 585054001535 GTP/Mg2+ binding site [chemical binding]; other site 585054001536 Switch I region; other site 585054001537 G2 box; other site 585054001538 G3 box; other site 585054001539 Switch II region; other site 585054001540 G4 box; other site 585054001541 G5 box; other site 585054001542 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 585054001543 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 585054001544 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 585054001545 signal peptidase I; Provisional; Region: PRK10861 585054001546 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585054001547 Catalytic site [active] 585054001548 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585054001549 ribonuclease III; Reviewed; Region: rnc; PRK00102 585054001550 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 585054001551 dimerization interface [polypeptide binding]; other site 585054001552 active site 585054001553 metal binding site [ion binding]; metal-binding site 585054001554 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 585054001555 dsRNA binding site [nucleotide binding]; other site 585054001556 GTPase Era; Reviewed; Region: era; PRK00089 585054001557 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 585054001558 G1 box; other site 585054001559 GTP/Mg2+ binding site [chemical binding]; other site 585054001560 Switch I region; other site 585054001561 G2 box; other site 585054001562 Switch II region; other site 585054001563 G3 box; other site 585054001564 G4 box; other site 585054001565 G5 box; other site 585054001566 KH domain; Region: KH_2; pfam07650 585054001567 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 585054001568 Recombination protein O N terminal; Region: RecO_N; pfam11967 585054001569 Recombination protein O C terminal; Region: RecO_C; pfam02565 585054001570 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 585054001571 active site 585054001572 hydrophilic channel; other site 585054001573 dimerization interface [polypeptide binding]; other site 585054001574 catalytic residues [active] 585054001575 active site lid [active] 585054001576 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 585054001577 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 585054001578 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585054001579 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 585054001580 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585054001581 putative active site [active] 585054001582 hypothetical protein; Provisional; Region: PRK11590 585054001583 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 585054001584 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 585054001585 nucleoside/Zn binding site; other site 585054001586 dimer interface [polypeptide binding]; other site 585054001587 catalytic motif [active] 585054001588 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 585054001589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054001590 substrate binding pocket [chemical binding]; other site 585054001591 membrane-bound complex binding site; other site 585054001592 hinge residues; other site 585054001593 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054001594 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054001595 catalytic residue [active] 585054001596 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 585054001597 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 585054001598 dimerization interface [polypeptide binding]; other site 585054001599 ATP binding site [chemical binding]; other site 585054001600 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 585054001601 dimerization interface [polypeptide binding]; other site 585054001602 ATP binding site [chemical binding]; other site 585054001603 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 585054001604 putative active site [active] 585054001605 catalytic triad [active] 585054001606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585054001607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054001608 dimer interface [polypeptide binding]; other site 585054001609 phosphorylation site [posttranslational modification] 585054001610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054001611 ATP binding site [chemical binding]; other site 585054001612 Mg2+ binding site [ion binding]; other site 585054001613 G-X-G motif; other site 585054001614 hypothetical protein; Provisional; Region: PRK10722 585054001615 response regulator GlrR; Provisional; Region: PRK15115 585054001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054001617 active site 585054001618 phosphorylation site [posttranslational modification] 585054001619 intermolecular recognition site; other site 585054001620 dimerization interface [polypeptide binding]; other site 585054001621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054001622 Walker A motif; other site 585054001623 ATP binding site [chemical binding]; other site 585054001624 Walker B motif; other site 585054001625 arginine finger; other site 585054001626 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 585054001627 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585054001628 adenylate kinase; Reviewed; Region: adk; PRK00279 585054001629 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 585054001630 AMP-binding site [chemical binding]; other site 585054001631 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 585054001632 ferrochelatase; Region: hemH; TIGR00109 585054001633 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 585054001634 C-terminal domain interface [polypeptide binding]; other site 585054001635 active site 585054001636 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 585054001637 active site 585054001638 N-terminal domain interface [polypeptide binding]; other site 585054001639 acetyl esterase; Provisional; Region: PRK10162 585054001640 inosine/guanosine kinase; Provisional; Region: PRK15074 585054001641 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585054001642 putative cation:proton antiport protein; Provisional; Region: PRK10669 585054001643 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 585054001644 TrkA-N domain; Region: TrkA_N; pfam02254 585054001645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585054001647 putative substrate translocation pore; other site 585054001648 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 585054001649 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 585054001650 active site 585054001651 metal binding site [ion binding]; metal-binding site 585054001652 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585054001653 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 585054001654 putative deacylase active site [active] 585054001655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 585054001656 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 585054001657 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585054001658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054001659 non-specific DNA binding site [nucleotide binding]; other site 585054001660 salt bridge; other site 585054001661 sequence-specific DNA binding site [nucleotide binding]; other site 585054001662 copper exporting ATPase; Provisional; Region: copA; PRK10671 585054001663 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585054001664 metal-binding site [ion binding] 585054001665 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585054001666 metal-binding site [ion binding] 585054001667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585054001668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054001669 motif II; other site 585054001670 amino acid transporter; Region: 2A0306; TIGR00909 585054001671 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 585054001672 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001673 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001674 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001675 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001676 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001677 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001678 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001679 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001680 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001681 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001682 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001683 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001684 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001685 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001686 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001687 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001688 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001689 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001690 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001691 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001692 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001693 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001694 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001695 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001696 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001697 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001698 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001699 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001700 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001701 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001702 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001703 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001704 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001705 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054001706 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054001707 Family description; Region: VCBS; pfam13517 585054001708 Family description; Region: VCBS; pfam13517 585054001709 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 585054001710 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 585054001711 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 585054001712 putative active site [active] 585054001713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054001714 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 585054001715 Walker A/P-loop; other site 585054001716 ATP binding site [chemical binding]; other site 585054001717 Q-loop/lid; other site 585054001718 ABC transporter signature motif; other site 585054001719 Walker B; other site 585054001720 D-loop; other site 585054001721 H-loop/switch region; other site 585054001722 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 585054001723 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 585054001724 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054001725 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 585054001726 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 585054001727 DNA binding residues [nucleotide binding] 585054001728 dimer interface [polypeptide binding]; other site 585054001729 copper binding site [ion binding]; other site 585054001730 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 585054001731 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585054001732 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585054001733 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 585054001734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054001735 Walker A/P-loop; other site 585054001736 ATP binding site [chemical binding]; other site 585054001737 Q-loop/lid; other site 585054001738 ABC transporter signature motif; other site 585054001739 Walker B; other site 585054001740 D-loop; other site 585054001741 H-loop/switch region; other site 585054001742 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 585054001743 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 585054001744 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 585054001745 oxidoreductase; Provisional; Region: PRK08017 585054001746 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 585054001747 NADP binding site [chemical binding]; other site 585054001748 active site 585054001749 steroid binding site; other site 585054001750 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 585054001751 active site 585054001752 catalytic triad [active] 585054001753 oxyanion hole [active] 585054001754 switch loop; other site 585054001755 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 585054001756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585054001757 Walker A/P-loop; other site 585054001758 ATP binding site [chemical binding]; other site 585054001759 Q-loop/lid; other site 585054001760 ABC transporter signature motif; other site 585054001761 Walker B; other site 585054001762 D-loop; other site 585054001763 H-loop/switch region; other site 585054001764 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 585054001765 FtsX-like permease family; Region: FtsX; pfam02687 585054001766 FtsX-like permease family; Region: FtsX; pfam02687 585054001767 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 585054001768 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 585054001769 active site residue [active] 585054001770 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585054001771 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585054001772 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585054001773 putative substrate binding site [chemical binding]; other site 585054001774 nucleotide binding site [chemical binding]; other site 585054001775 nucleotide binding site [chemical binding]; other site 585054001776 homodimer interface [polypeptide binding]; other site 585054001777 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of N5-carboxyaminoimidazole ribonucleotide synthase (part 2) 585054001778 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of N5-carboxyaminoimidazole ribonucleotide synthase (part 1) 585054001779 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 585054001780 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 585054001781 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585054001782 putative active site [active] 585054001783 putative metal binding site [ion binding]; other site 585054001784 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585054001785 substrate binding site [chemical binding]; other site 585054001786 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 585054001787 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585054001788 active site 585054001789 HIGH motif; other site 585054001790 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585054001791 KMSKS motif; other site 585054001792 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 585054001793 tRNA binding surface [nucleotide binding]; other site 585054001794 anticodon binding site; other site 585054001795 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 585054001796 ribosome-associated protein; Provisional; Region: PRK11507 585054001797 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 585054001798 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 585054001799 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 585054001800 homodimer interface [polypeptide binding]; other site 585054001801 NADP binding site [chemical binding]; other site 585054001802 substrate binding site [chemical binding]; other site 585054001803 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 585054001804 Int/Topo IB signature motif; other site 585054001805 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585054001806 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585054001807 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 585054001808 Dimer interface [polypeptide binding]; other site 585054001809 Predicted transcriptional regulator [Transcription]; Region: COG2932 585054001810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054001811 non-specific DNA binding site [nucleotide binding]; other site 585054001812 salt bridge; other site 585054001813 sequence-specific DNA binding site [nucleotide binding]; other site 585054001814 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054001815 Catalytic site [active] 585054001816 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 585054001817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054001818 DNA-binding site [nucleotide binding]; DNA binding site 585054001819 PerC transcriptional activator; Region: PerC; pfam06069 585054001820 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 585054001821 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585054001822 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 585054001823 KilA-N domain; Region: KilA-N; pfam04383 585054001824 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585054001825 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585054001826 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 585054001827 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 585054001828 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054001829 catalytic residue [active] 585054001830 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585054001831 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585054001832 active site 585054001833 Phage terminase, small subunit; Region: Terminase_4; pfam05119 585054001834 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585054001835 Phage-related protein [Function unknown]; Region: COG4695 585054001836 Phage portal protein; Region: Phage_portal; pfam04860 585054001837 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 585054001838 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585054001839 Phage capsid family; Region: Phage_capsid; pfam05065 585054001840 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 585054001841 oligomerization interface [polypeptide binding]; other site 585054001842 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 585054001843 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 585054001844 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 585054001845 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 585054001846 Phage tail tube protein; Region: Tail_tube; pfam10618 585054001847 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585054001848 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585054001849 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 585054001850 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 585054001851 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 585054001852 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 585054001853 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585054001854 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585054001855 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 585054001856 Phage protein GP46; Region: GP46; pfam07409 585054001857 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 585054001858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 585054001859 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585054001860 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585054001861 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 585054001862 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 585054001863 Ligand binding site; other site 585054001864 Putative Catalytic site; other site 585054001865 DXD motif; other site 585054001866 Predicted membrane protein [Function unknown]; Region: COG2246 585054001867 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 585054001868 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 585054001869 heme-binding site [chemical binding]; other site 585054001870 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 585054001871 FAD binding pocket [chemical binding]; other site 585054001872 FAD binding motif [chemical binding]; other site 585054001873 phosphate binding motif [ion binding]; other site 585054001874 beta-alpha-beta structure motif; other site 585054001875 NAD binding pocket [chemical binding]; other site 585054001876 Heme binding pocket [chemical binding]; other site 585054001877 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 585054001878 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 585054001879 dimer interface [polypeptide binding]; other site 585054001880 active site 585054001881 glycine-pyridoxal phosphate binding site [chemical binding]; other site 585054001882 folate binding site [chemical binding]; other site 585054001883 Predicted membrane protein [Function unknown]; Region: COG2259 585054001884 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 585054001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054001886 putative substrate translocation pore; other site 585054001887 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 585054001888 PRD domain; Region: PRD; pfam00874 585054001889 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585054001890 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585054001891 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585054001892 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 585054001893 active site 585054001894 dimerization interface [polypeptide binding]; other site 585054001895 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 585054001896 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 585054001897 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 585054001898 Rrf2 family protein; Region: rrf2_super; TIGR00738 585054001899 cysteine desulfurase; Provisional; Region: PRK14012 585054001900 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 585054001901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585054001902 catalytic residue [active] 585054001903 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 585054001904 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 585054001905 trimerization site [polypeptide binding]; other site 585054001906 active site 585054001907 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 585054001908 co-chaperone HscB; Provisional; Region: hscB; PRK05014 585054001909 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585054001910 HSP70 interaction site [polypeptide binding]; other site 585054001911 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 585054001912 chaperone protein HscA; Provisional; Region: hscA; PRK05183 585054001913 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 585054001914 nucleotide binding site [chemical binding]; other site 585054001915 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585054001916 SBD interface [polypeptide binding]; other site 585054001917 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585054001918 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054001919 catalytic loop [active] 585054001920 iron binding site [ion binding]; other site 585054001921 hypothetical protein; Provisional; Region: PRK10721 585054001922 aminopeptidase B; Provisional; Region: PRK05015 585054001923 Peptidase; Region: DUF3663; pfam12404 585054001924 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585054001925 interface (dimer of trimers) [polypeptide binding]; other site 585054001926 Substrate-binding/catalytic site; other site 585054001927 Zn-binding sites [ion binding]; other site 585054001928 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 585054001929 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 585054001930 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585054001931 active site residue [active] 585054001932 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585054001933 active site residue [active] 585054001934 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585054001935 MG2 domain; Region: A2M_N; pfam01835 585054001936 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585054001937 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 585054001938 surface patch; other site 585054001939 thioester region; other site 585054001940 specificity defining residues; other site 585054001941 penicillin-binding protein 1C; Provisional; Region: PRK11240 585054001942 Transglycosylase; Region: Transgly; pfam00912 585054001943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585054001944 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 585054001945 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 585054001946 active site 585054001947 multimer interface [polypeptide binding]; other site 585054001948 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 585054001949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054001950 FeS/SAM binding site; other site 585054001951 cytoskeletal protein RodZ; Provisional; Region: PRK10856 585054001952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054001953 non-specific DNA binding site [nucleotide binding]; other site 585054001954 salt bridge; other site 585054001955 sequence-specific DNA binding site [nucleotide binding]; other site 585054001956 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 585054001957 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 585054001958 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585054001959 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585054001960 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 585054001961 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 585054001962 dimer interface [polypeptide binding]; other site 585054001963 motif 1; other site 585054001964 active site 585054001965 motif 2; other site 585054001966 motif 3; other site 585054001967 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 585054001968 anticodon binding site; other site 585054001969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 585054001970 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 585054001971 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 585054001972 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 585054001973 Trp docking motif [polypeptide binding]; other site 585054001974 active site 585054001975 GTP-binding protein Der; Reviewed; Region: PRK00093 585054001976 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 585054001977 G1 box; other site 585054001978 GTP/Mg2+ binding site [chemical binding]; other site 585054001979 Switch I region; other site 585054001980 G2 box; other site 585054001981 Switch II region; other site 585054001982 G3 box; other site 585054001983 G4 box; other site 585054001984 G5 box; other site 585054001985 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 585054001986 G1 box; other site 585054001987 GTP/Mg2+ binding site [chemical binding]; other site 585054001988 Switch I region; other site 585054001989 G2 box; other site 585054001990 G3 box; other site 585054001991 Switch II region; other site 585054001992 G4 box; other site 585054001993 G5 box; other site 585054001994 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 585054001995 intimin-like protein SinH; Provisional; Region: PRK15318 585054001996 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585054001997 intimin-like protein SinH; Provisional; Region: PRK15318 585054001998 RatA-like protein; Provisional; Region: PRK15316 585054001999 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002000 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002001 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002002 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002003 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002004 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002005 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002006 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002007 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002008 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002009 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002010 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002011 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002012 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002013 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002014 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002015 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585054002016 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585054002017 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 585054002018 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 585054002019 generic binding surface II; other site 585054002020 generic binding surface I; other site 585054002021 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 585054002022 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585054002023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 585054002024 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585054002025 active site 585054002026 GMP synthase; Reviewed; Region: guaA; PRK00074 585054002027 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 585054002028 AMP/PPi binding site [chemical binding]; other site 585054002029 candidate oxyanion hole; other site 585054002030 catalytic triad [active] 585054002031 potential glutamine specificity residues [chemical binding]; other site 585054002032 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 585054002033 ATP Binding subdomain [chemical binding]; other site 585054002034 Ligand Binding sites [chemical binding]; other site 585054002035 Dimerization subdomain; other site 585054002036 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 585054002037 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 585054002038 MASE1; Region: MASE1; pfam05231 585054002039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054002040 diguanylate cyclase; Region: GGDEF; smart00267 585054002041 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054002042 exopolyphosphatase; Provisional; Region: PRK10854 585054002043 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585054002044 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 585054002045 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 585054002046 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 585054002047 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585054002048 putative active site [active] 585054002049 catalytic site [active] 585054002050 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 585054002051 domain interface [polypeptide binding]; other site 585054002052 active site 585054002053 catalytic site [active] 585054002054 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 585054002055 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 585054002056 active site 585054002057 substrate binding site [chemical binding]; other site 585054002058 cosubstrate binding site; other site 585054002059 catalytic site [active] 585054002060 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 585054002061 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 585054002062 dimerization interface [polypeptide binding]; other site 585054002063 putative ATP binding site [chemical binding]; other site 585054002064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054002065 active site 585054002066 uracil transporter; Provisional; Region: PRK10720 585054002067 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 585054002068 DNA replication initiation factor; Provisional; Region: PRK08084 585054002069 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585054002070 ArsC family; Region: ArsC; pfam03960 585054002071 catalytic residues [active] 585054002072 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 585054002073 Peptidase family M48; Region: Peptidase_M48; cl12018 585054002074 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 585054002075 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585054002076 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 585054002077 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585054002078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054002079 Walker A motif; other site 585054002080 ATP binding site [chemical binding]; other site 585054002081 Walker B motif; other site 585054002082 arginine finger; other site 585054002083 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054002084 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585054002085 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585054002086 hydrogenase 4 subunit H; Validated; Region: PRK08222 585054002087 4Fe-4S binding domain; Region: Fer4; pfam00037 585054002088 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585054002089 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585054002090 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585054002091 hydrogenase 4 subunit F; Validated; Region: PRK06458 585054002092 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054002093 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 585054002094 hydrogenase 4 subunit D; Validated; Region: PRK06525 585054002095 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054002096 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585054002097 NADH dehydrogenase; Region: NADHdh; cl00469 585054002098 hydrogenase 4 subunit B; Validated; Region: PRK06521 585054002099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054002100 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585054002101 4Fe-4S binding domain; Region: Fer4; pfam00037 585054002102 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 585054002103 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 585054002104 catalytic triad [active] 585054002105 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 585054002106 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 585054002107 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585054002108 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 585054002109 dihydrodipicolinate synthase; Region: dapA; TIGR00674 585054002110 dimer interface [polypeptide binding]; other site 585054002111 active site 585054002112 catalytic residue [active] 585054002113 lipoprotein; Provisional; Region: PRK11679 585054002114 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 585054002115 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 585054002116 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 585054002117 ATP binding site [chemical binding]; other site 585054002118 active site 585054002119 substrate binding site [chemical binding]; other site 585054002120 Predicted metalloprotease [General function prediction only]; Region: COG2321 585054002121 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 585054002122 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 585054002123 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 585054002124 Helicase; Region: Helicase_RecD; pfam05127 585054002125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054002126 Coenzyme A binding pocket [chemical binding]; other site 585054002127 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 585054002128 putative hydrolase; Provisional; Region: PRK11460 585054002129 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 585054002130 hypothetical protein; Provisional; Region: PRK13664 585054002131 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 585054002132 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 585054002133 metal binding site [ion binding]; metal-binding site 585054002134 dimer interface [polypeptide binding]; other site 585054002135 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 585054002136 ArsC family; Region: ArsC; pfam03960 585054002137 putative catalytic residues [active] 585054002138 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 585054002139 Protein export membrane protein; Region: SecD_SecF; cl14618 585054002140 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 585054002141 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585054002142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054002143 dimerization interface [polypeptide binding]; other site 585054002144 Histidine kinase; Region: HisKA_3; pfam07730 585054002145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054002146 ATP binding site [chemical binding]; other site 585054002147 Mg2+ binding site [ion binding]; other site 585054002148 G-X-G motif; other site 585054002149 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 585054002150 4Fe-4S binding domain; Region: Fer4; pfam00037 585054002151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054002152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054002153 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 585054002154 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585054002155 dimer interface [polypeptide binding]; other site 585054002156 ADP-ribose binding site [chemical binding]; other site 585054002157 active site 585054002158 nudix motif; other site 585054002159 metal binding site [ion binding]; metal-binding site 585054002160 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 585054002161 transketolase; Reviewed; Region: PRK12753 585054002162 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585054002163 TPP-binding site [chemical binding]; other site 585054002164 dimer interface [polypeptide binding]; other site 585054002165 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585054002166 PYR/PP interface [polypeptide binding]; other site 585054002167 dimer interface [polypeptide binding]; other site 585054002168 TPP binding site [chemical binding]; other site 585054002169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585054002170 transaldolase-like protein; Provisional; Region: PTZ00411 585054002171 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585054002172 active site 585054002173 dimer interface [polypeptide binding]; other site 585054002174 catalytic residue [active] 585054002175 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 585054002176 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585054002177 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 585054002178 putative NAD(P) binding site [chemical binding]; other site 585054002179 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 585054002180 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 585054002181 putative hexamer interface [polypeptide binding]; other site 585054002182 putative hexagonal pore; other site 585054002183 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585054002184 G1 box; other site 585054002185 GTP/Mg2+ binding site [chemical binding]; other site 585054002186 G2 box; other site 585054002187 Switch I region; other site 585054002188 G3 box; other site 585054002189 Switch II region; other site 585054002190 G4 box; other site 585054002191 G5 box; other site 585054002192 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 585054002193 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 585054002194 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 585054002195 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 585054002196 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054002197 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 585054002198 Hexamer interface [polypeptide binding]; other site 585054002199 Putative hexagonal pore residue; other site 585054002200 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 585054002201 Hexamer/Pentamer interface [polypeptide binding]; other site 585054002202 central pore; other site 585054002203 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585054002204 putative catalytic cysteine [active] 585054002205 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 585054002206 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054002207 nucleotide binding site [chemical binding]; other site 585054002208 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 585054002209 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 585054002210 active site 585054002211 metal binding site [ion binding]; metal-binding site 585054002212 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 585054002213 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 585054002214 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 585054002215 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 585054002216 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 585054002217 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 585054002218 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 585054002219 putative hexamer interface [polypeptide binding]; other site 585054002220 putative hexagonal pore; other site 585054002221 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 585054002222 putative hexamer interface [polypeptide binding]; other site 585054002223 putative hexagonal pore; other site 585054002224 carboxysome structural protein EutK; Provisional; Region: PRK15466 585054002225 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585054002226 Hexamer interface [polypeptide binding]; other site 585054002227 Hexagonal pore residue; other site 585054002228 transcriptional regulator EutR; Provisional; Region: PRK10130 585054002229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054002230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054002231 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 585054002232 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 585054002233 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 585054002234 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 585054002235 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585054002236 active site 585054002237 metal binding site [ion binding]; metal-binding site 585054002238 putative acetyltransferase; Provisional; Region: PRK03624 585054002239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054002240 Coenzyme A binding pocket [chemical binding]; other site 585054002241 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 585054002242 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 585054002243 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 585054002244 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 585054002245 putative periplasmic esterase; Provisional; Region: PRK03642 585054002246 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585054002247 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 585054002248 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054002249 active site turn [active] 585054002250 phosphorylation site [posttranslational modification] 585054002251 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585054002252 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 585054002253 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 585054002254 putative active site [active] 585054002255 transcriptional regulator MurR; Provisional; Region: PRK15482 585054002256 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585054002257 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585054002258 putative active site [active] 585054002259 short chain dehydrogenase; Provisional; Region: PRK08226 585054002260 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 585054002261 NAD binding site [chemical binding]; other site 585054002262 homotetramer interface [polypeptide binding]; other site 585054002263 homodimer interface [polypeptide binding]; other site 585054002264 active site 585054002265 thiosulfate transporter subunit; Provisional; Region: PRK10852 585054002266 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585054002267 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585054002268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054002269 dimer interface [polypeptide binding]; other site 585054002270 conserved gate region; other site 585054002271 putative PBP binding loops; other site 585054002272 ABC-ATPase subunit interface; other site 585054002273 sulfate transport protein; Provisional; Region: cysT; CHL00187 585054002274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054002275 dimer interface [polypeptide binding]; other site 585054002276 conserved gate region; other site 585054002277 putative PBP binding loops; other site 585054002278 ABC-ATPase subunit interface; other site 585054002279 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 585054002280 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 585054002281 Walker A/P-loop; other site 585054002282 ATP binding site [chemical binding]; other site 585054002283 Q-loop/lid; other site 585054002284 ABC transporter signature motif; other site 585054002285 Walker B; other site 585054002286 D-loop; other site 585054002287 H-loop/switch region; other site 585054002288 TOBE-like domain; Region: TOBE_3; pfam12857 585054002289 cysteine synthase B; Region: cysM; TIGR01138 585054002290 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585054002291 dimer interface [polypeptide binding]; other site 585054002292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054002293 catalytic residue [active] 585054002294 hypothetical protein; Provisional; Region: PRK10318 585054002295 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585054002296 dimer interface [polypeptide binding]; other site 585054002297 pyridoxamine kinase; Validated; Region: PRK05756 585054002298 pyridoxal binding site [chemical binding]; other site 585054002299 ATP binding site [chemical binding]; other site 585054002300 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585054002301 HPr interaction site; other site 585054002302 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585054002303 active site 585054002304 phosphorylation site [posttranslational modification] 585054002305 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 585054002306 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585054002307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585054002308 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585054002309 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585054002310 dimerization domain swap beta strand [polypeptide binding]; other site 585054002311 regulatory protein interface [polypeptide binding]; other site 585054002312 active site 585054002313 regulatory phosphorylation site [posttranslational modification]; other site 585054002314 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 585054002315 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585054002316 dimer interface [polypeptide binding]; other site 585054002317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054002318 catalytic residue [active] 585054002319 putative sulfate transport protein CysZ; Validated; Region: PRK04949 585054002320 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 585054002321 cell division protein ZipA; Provisional; Region: PRK03427 585054002322 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 585054002323 FtsZ protein binding site [polypeptide binding]; other site 585054002324 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 585054002325 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 585054002326 nucleotide binding pocket [chemical binding]; other site 585054002327 K-X-D-G motif; other site 585054002328 catalytic site [active] 585054002329 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585054002330 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 585054002331 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 585054002332 Dimer interface [polypeptide binding]; other site 585054002333 BRCT sequence motif; other site 585054002334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 585054002335 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 585054002336 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 585054002337 hypothetical protein; Provisional; Region: PRK11528 585054002338 purine nucleoside phosphorylase; Provisional; Region: PRK08202 585054002339 nucleoside transporter; Region: 2A0110; TIGR00889 585054002340 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585054002341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054002342 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 585054002343 putative dimerization interface [polypeptide binding]; other site 585054002344 putative substrate binding pocket [chemical binding]; other site 585054002345 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 585054002346 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585054002347 active site 585054002348 HIGH motif; other site 585054002349 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585054002350 active site 585054002351 KMSKS motif; other site 585054002352 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 585054002353 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 585054002354 MASE1; Region: MASE1; pfam05231 585054002355 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054002356 diguanylate cyclase; Region: GGDEF; smart00267 585054002357 metal binding site [ion binding]; metal-binding site 585054002358 nucleotidyl binding site; other site 585054002359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054002360 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585054002361 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585054002362 Nucleoside recognition; Region: Gate; pfam07670 585054002363 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585054002364 manganese transport protein MntH; Reviewed; Region: PRK00701 585054002365 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 585054002366 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585054002367 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585054002368 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585054002369 Cl- selectivity filter; other site 585054002370 Cl- binding residues [ion binding]; other site 585054002371 pore gating glutamate residue; other site 585054002372 dimer interface [polypeptide binding]; other site 585054002373 glucokinase, proteobacterial type; Region: glk; TIGR00749 585054002374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054002375 nucleotide binding site [chemical binding]; other site 585054002376 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585054002377 active site 585054002378 P-loop; other site 585054002379 phosphorylation site [posttranslational modification] 585054002380 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585054002381 aminopeptidase; Provisional; Region: PRK09795 585054002382 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 585054002383 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 585054002384 active site 585054002385 exoaminopeptidase; Provisional; Region: PRK09961 585054002386 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 585054002387 oligomer interface [polypeptide binding]; other site 585054002388 active site 585054002389 metal binding site [ion binding]; metal-binding site 585054002390 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585054002391 dimerization domain swap beta strand [polypeptide binding]; other site 585054002392 regulatory protein interface [polypeptide binding]; other site 585054002393 active site 585054002394 regulatory phosphorylation site [posttranslational modification]; other site 585054002395 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585054002396 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585054002397 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585054002398 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585054002399 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054002400 active site 585054002401 phosphorylation site [posttranslational modification] 585054002402 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585054002403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054002404 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 585054002405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054002406 active site 585054002407 phosphorylation site [posttranslational modification] 585054002408 intermolecular recognition site; other site 585054002409 dimerization interface [polypeptide binding]; other site 585054002410 LytTr DNA-binding domain; Region: LytTR; pfam04397 585054002411 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585054002412 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585054002413 GAF domain; Region: GAF; pfam01590 585054002414 Histidine kinase; Region: His_kinase; pfam06580 585054002415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054002416 ATP binding site [chemical binding]; other site 585054002417 Mg2+ binding site [ion binding]; other site 585054002418 G-X-G motif; other site 585054002419 aminotransferase; Validated; Region: PRK08175 585054002420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054002421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054002422 homodimer interface [polypeptide binding]; other site 585054002423 catalytic residue [active] 585054002424 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585054002425 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585054002426 putative acyl-acceptor binding pocket; other site 585054002427 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 585054002428 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 585054002429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054002430 putative substrate translocation pore; other site 585054002431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585054002432 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 585054002433 Amidase; Region: Amidase; cl11426 585054002434 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 585054002435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 585054002436 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 585054002437 active site 585054002438 SnoaL-like domain; Region: SnoaL_4; pfam13577 585054002439 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 585054002440 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 585054002441 [2Fe-2S] cluster binding site [ion binding]; other site 585054002442 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 585054002443 putative alpha subunit interface [polypeptide binding]; other site 585054002444 putative active site [active] 585054002445 putative substrate binding site [chemical binding]; other site 585054002446 Fe binding site [ion binding]; other site 585054002447 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 585054002448 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 585054002449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054002450 NAD(P) binding site [chemical binding]; other site 585054002451 active site 585054002452 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 585054002453 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 585054002454 FMN-binding pocket [chemical binding]; other site 585054002455 flavin binding motif; other site 585054002456 phosphate binding motif [ion binding]; other site 585054002457 beta-alpha-beta structure motif; other site 585054002458 NAD binding pocket [chemical binding]; other site 585054002459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054002460 catalytic loop [active] 585054002461 iron binding site [ion binding]; other site 585054002462 Flavin Reductases; Region: FlaRed; cl00801 585054002463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054002464 metabolite-proton symporter; Region: 2A0106; TIGR00883 585054002465 putative substrate translocation pore; other site 585054002466 SEC-C motif; Region: SEC-C; pfam02810 585054002467 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 585054002468 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 585054002469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 585054002470 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 585054002471 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 585054002472 active site 585054002473 metal binding site [ion binding]; metal-binding site 585054002474 interdomain interaction site; other site 585054002475 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 585054002476 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 585054002477 integrase; Provisional; Region: PRK09692 585054002478 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585054002479 active site 585054002480 Int/Topo IB signature motif; other site 585054002481 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 585054002482 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 585054002483 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 585054002484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 585054002485 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 585054002486 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585054002487 dimer interface [polypeptide binding]; other site 585054002488 active site 585054002489 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 585054002490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054002491 substrate binding site [chemical binding]; other site 585054002492 oxyanion hole (OAH) forming residues; other site 585054002493 trimer interface [polypeptide binding]; other site 585054002494 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585054002495 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585054002496 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585054002497 catalytic core [active] 585054002498 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585054002499 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 585054002500 PapC N-terminal domain; Region: PapC_N; pfam13954 585054002501 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054002502 PapC C-terminal domain; Region: PapC_C; pfam13953 585054002503 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 585054002504 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054002505 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054002506 Fimbrial protein; Region: Fimbrial; cl01416 585054002507 Fimbrial protein; Region: Fimbrial; cl01416 585054002508 Fimbrial protein; Region: Fimbrial; cl01416 585054002509 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 585054002510 hypothetical protein; Provisional; Region: PRK04946 585054002511 Smr domain; Region: Smr; pfam01713 585054002512 HemK family putative methylases; Region: hemK_fam; TIGR00536 585054002513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054002514 S-adenosylmethionine binding site [chemical binding]; other site 585054002515 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 585054002516 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 585054002517 Tetramer interface [polypeptide binding]; other site 585054002518 active site 585054002519 FMN-binding site [chemical binding]; other site 585054002520 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 585054002521 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 585054002522 hypothetical protein; Provisional; Region: PRK10621 585054002523 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 585054002524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 585054002525 YfcL protein; Region: YfcL; pfam08891 585054002526 Uncharacterized conserved protein [Function unknown]; Region: COG4121 585054002527 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 585054002528 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 585054002529 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585054002530 dimer interface [polypeptide binding]; other site 585054002531 active site 585054002532 putative transporter; Provisional; Region: PRK12382 585054002533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054002534 putative substrate translocation pore; other site 585054002535 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 585054002536 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 585054002537 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 585054002538 ligand binding site [chemical binding]; other site 585054002539 NAD binding site [chemical binding]; other site 585054002540 catalytic site [active] 585054002541 homodimer interface [polypeptide binding]; other site 585054002542 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 585054002543 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585054002544 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 585054002545 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 585054002546 dimerization interface 3.5A [polypeptide binding]; other site 585054002547 active site 585054002548 hypothetical protein; Provisional; Region: PRK10847 585054002549 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585054002550 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 585054002551 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 585054002552 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 585054002553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585054002554 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585054002555 cell division protein DedD; Provisional; Region: PRK11633 585054002556 Sporulation related domain; Region: SPOR; pfam05036 585054002557 colicin V production protein; Provisional; Region: PRK10845 585054002558 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 585054002559 amidophosphoribosyltransferase; Provisional; Region: PRK09246 585054002560 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 585054002561 active site 585054002562 tetramer interface [polypeptide binding]; other site 585054002563 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054002564 active site 585054002565 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 585054002566 Flavoprotein; Region: Flavoprotein; pfam02441 585054002567 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 585054002568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054002569 substrate binding pocket [chemical binding]; other site 585054002570 membrane-bound complex binding site; other site 585054002571 hinge residues; other site 585054002572 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 585054002573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054002574 substrate binding pocket [chemical binding]; other site 585054002575 membrane-bound complex binding site; other site 585054002576 hinge residues; other site 585054002577 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054002579 dimer interface [polypeptide binding]; other site 585054002580 conserved gate region; other site 585054002581 putative PBP binding loops; other site 585054002582 ABC-ATPase subunit interface; other site 585054002583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054002584 dimer interface [polypeptide binding]; other site 585054002585 conserved gate region; other site 585054002586 putative PBP binding loops; other site 585054002587 ABC-ATPase subunit interface; other site 585054002588 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 585054002589 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585054002590 Walker A/P-loop; other site 585054002591 ATP binding site [chemical binding]; other site 585054002592 Q-loop/lid; other site 585054002593 ABC transporter signature motif; other site 585054002594 Walker B; other site 585054002595 D-loop; other site 585054002596 H-loop/switch region; other site 585054002597 putative transposase; Provisional; Region: PRK09857 585054002598 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585054002599 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 585054002600 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 585054002601 putative NAD(P) binding site [chemical binding]; other site 585054002602 putative active site [active] 585054002603 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585054002604 homooctamer interface [polypeptide binding]; other site 585054002605 active site 585054002606 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 585054002607 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585054002608 C-terminal domain interface [polypeptide binding]; other site 585054002609 GSH binding site (G-site) [chemical binding]; other site 585054002610 dimer interface [polypeptide binding]; other site 585054002611 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 585054002612 N-terminal domain interface [polypeptide binding]; other site 585054002613 putative dimer interface [polypeptide binding]; other site 585054002614 active site 585054002615 glutathione S-transferase; Provisional; Region: PRK15113 585054002616 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 585054002617 C-terminal domain interface [polypeptide binding]; other site 585054002618 GSH binding site (G-site) [chemical binding]; other site 585054002619 dimer interface [polypeptide binding]; other site 585054002620 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 585054002621 N-terminal domain interface [polypeptide binding]; other site 585054002622 putative dimer interface [polypeptide binding]; other site 585054002623 putative substrate binding pocket (H-site) [chemical binding]; other site 585054002624 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 585054002625 active site 585054002626 metal binding site [ion binding]; metal-binding site 585054002627 homotetramer interface [polypeptide binding]; other site 585054002628 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 585054002629 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 585054002630 nudix motif; other site 585054002631 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054002632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054002633 DNA binding site [nucleotide binding] 585054002634 domain linker motif; other site 585054002635 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585054002636 putative dimerization interface [polypeptide binding]; other site 585054002637 putative ligand binding site [chemical binding]; other site 585054002638 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054002639 active site 585054002640 phosphorylation site [posttranslational modification] 585054002641 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585054002642 active site 585054002643 P-loop; other site 585054002644 phosphorylation site [posttranslational modification] 585054002645 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 585054002646 transketolase; Reviewed; Region: PRK05899 585054002647 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585054002648 TPP-binding site [chemical binding]; other site 585054002649 dimer interface [polypeptide binding]; other site 585054002650 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 585054002651 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585054002652 PYR/PP interface [polypeptide binding]; other site 585054002653 dimer interface [polypeptide binding]; other site 585054002654 TPP binding site [chemical binding]; other site 585054002655 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585054002656 phosphate acetyltransferase; Reviewed; Region: PRK05632 585054002657 DRTGG domain; Region: DRTGG; pfam07085 585054002658 phosphate acetyltransferase; Region: pta; TIGR00651 585054002659 propionate/acetate kinase; Provisional; Region: PRK12379 585054002660 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 585054002661 hypothetical protein; Provisional; Region: PRK01816 585054002662 hypothetical protein; Validated; Region: PRK05445 585054002663 putative phosphatase; Provisional; Region: PRK11587 585054002664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054002665 motif II; other site 585054002666 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585054002667 transmembrane helices; other site 585054002668 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585054002669 TrkA-C domain; Region: TrkA_C; pfam02080 585054002670 TrkA-C domain; Region: TrkA_C; pfam02080 585054002671 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 585054002672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054002673 Zn2+ binding site [ion binding]; other site 585054002674 Mg2+ binding site [ion binding]; other site 585054002675 aminotransferase AlaT; Validated; Region: PRK09265 585054002676 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054002677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054002678 homodimer interface [polypeptide binding]; other site 585054002679 catalytic residue [active] 585054002680 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 585054002681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054002682 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 585054002683 putative dimerization interface [polypeptide binding]; other site 585054002684 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 585054002685 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 585054002686 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 585054002687 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 585054002688 NADH dehydrogenase subunit D; Validated; Region: PRK06075 585054002689 NADH dehydrogenase subunit E; Validated; Region: PRK07539 585054002690 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 585054002691 putative dimer interface [polypeptide binding]; other site 585054002692 [2Fe-2S] cluster binding site [ion binding]; other site 585054002693 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 585054002694 SLBB domain; Region: SLBB; pfam10531 585054002695 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 585054002696 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 585054002697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054002698 catalytic loop [active] 585054002699 iron binding site [ion binding]; other site 585054002700 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 585054002701 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 585054002702 [4Fe-4S] binding site [ion binding]; other site 585054002703 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 585054002704 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 585054002705 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 585054002706 4Fe-4S binding domain; Region: Fer4; pfam00037 585054002707 4Fe-4S binding domain; Region: Fer4; pfam00037 585054002708 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 585054002709 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 585054002710 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 585054002711 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 585054002712 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054002713 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 585054002714 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054002715 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 585054002716 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585054002717 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 585054002718 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 585054002719 von Willebrand factor; Region: vWF_A; pfam12450 585054002720 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 585054002721 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 585054002722 metal ion-dependent adhesion site (MIDAS); other site 585054002723 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 585054002724 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 585054002725 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 585054002726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054002727 active site 585054002728 phosphorylation site [posttranslational modification] 585054002729 intermolecular recognition site; other site 585054002730 dimerization interface [polypeptide binding]; other site 585054002731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 585054002732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054002733 Coenzyme A binding pocket [chemical binding]; other site 585054002734 hypothetical protein; Provisional; Region: PRK10404 585054002735 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 585054002736 isochorismate synthases; Region: isochor_syn; TIGR00543 585054002737 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 585054002738 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 585054002739 dimer interface [polypeptide binding]; other site 585054002740 tetramer interface [polypeptide binding]; other site 585054002741 PYR/PP interface [polypeptide binding]; other site 585054002742 TPP binding site [chemical binding]; other site 585054002743 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 585054002744 TPP-binding site; other site 585054002745 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 585054002746 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 585054002747 nucleophilic elbow; other site 585054002748 catalytic triad; other site 585054002749 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054002750 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 585054002751 substrate binding site [chemical binding]; other site 585054002752 oxyanion hole (OAH) forming residues; other site 585054002753 trimer interface [polypeptide binding]; other site 585054002754 O-succinylbenzoate synthase; Provisional; Region: PRK05105 585054002755 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 585054002756 active site 585054002757 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 585054002758 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 585054002759 acyl-activating enzyme (AAE) consensus motif; other site 585054002760 putative AMP binding site [chemical binding]; other site 585054002761 putative active site [active] 585054002762 putative CoA binding site [chemical binding]; other site 585054002763 signal transduction protein PmrD; Provisional; Region: PRK15450 585054002764 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 585054002765 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 585054002766 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 585054002767 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 585054002768 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 585054002769 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 585054002770 putative active site [active] 585054002771 putative catalytic site [active] 585054002772 putative Zn binding site [ion binding]; other site 585054002773 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 585054002774 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 585054002775 active site 585054002776 substrate binding site [chemical binding]; other site 585054002777 cosubstrate binding site; other site 585054002778 catalytic site [active] 585054002779 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 585054002780 active site 585054002781 hexamer interface [polypeptide binding]; other site 585054002782 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 585054002783 NAD binding site [chemical binding]; other site 585054002784 substrate binding site [chemical binding]; other site 585054002785 active site 585054002786 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 585054002787 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 585054002788 Ligand binding site; other site 585054002789 Putative Catalytic site; other site 585054002790 DXD motif; other site 585054002791 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585054002792 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585054002793 inhibitor-cofactor binding pocket; inhibition site 585054002794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054002795 catalytic residue [active] 585054002796 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 585054002797 catalytic core [active] 585054002798 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 585054002799 YfaZ precursor; Region: YfaZ; pfam07437 585054002800 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 585054002801 hypothetical protein; Provisional; Region: PRK03673 585054002802 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 585054002803 putative MPT binding site; other site 585054002804 Competence-damaged protein; Region: CinA; cl00666 585054002805 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585054002806 hypothetical protein; Provisional; Region: PRK09956 585054002807 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585054002808 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 585054002809 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585054002810 Cysteine-rich domain; Region: CCG; pfam02754 585054002811 Cysteine-rich domain; Region: CCG; pfam02754 585054002812 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 585054002813 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 585054002814 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 585054002815 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585054002816 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585054002817 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 585054002818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054002819 putative substrate translocation pore; other site 585054002820 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 585054002821 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 585054002822 active site 585054002823 catalytic site [active] 585054002824 metal binding site [ion binding]; metal-binding site 585054002825 hypothetical protein; Provisional; Region: PRK09902 585054002826 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585054002827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054002828 catalytic loop [active] 585054002829 iron binding site [ion binding]; other site 585054002830 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585054002831 dimer interface [polypeptide binding]; other site 585054002832 putative radical transfer pathway; other site 585054002833 diiron center [ion binding]; other site 585054002834 tyrosyl radical; other site 585054002835 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 585054002836 ATP cone domain; Region: ATP-cone; pfam03477 585054002837 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585054002838 active site 585054002839 dimer interface [polypeptide binding]; other site 585054002840 catalytic residues [active] 585054002841 effector binding site; other site 585054002842 R2 peptide binding site; other site 585054002843 adhesin; Provisional; Region: PRK09752 585054002844 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585054002845 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585054002846 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 585054002847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054002848 S-adenosylmethionine binding site [chemical binding]; other site 585054002849 DNA gyrase subunit A; Validated; Region: PRK05560 585054002850 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585054002851 CAP-like domain; other site 585054002852 active site 585054002853 primary dimer interface [polypeptide binding]; other site 585054002854 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054002855 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054002856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054002857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054002858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054002859 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054002860 putative acyltransferase; Provisional; Region: PRK05790 585054002861 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585054002862 dimer interface [polypeptide binding]; other site 585054002863 active site 585054002864 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 585054002865 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 585054002866 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 585054002867 Evidence 7 : Gene remnant; Product type r : regulator; fragment of fused response regulator of ato opeon, in two-component system with AtoS: response regulator ; sigma54 interaction protein (part 2) 585054002868 Evidence 7 : Gene remnant; Product type r : regulator; fragment of fused response regulator of ato opeon, in two-component system with AtoS: response regulator ; sigma54 interaction protein (part 1) 585054002869 sensory histidine kinase AtoS; Provisional; Region: PRK11360 585054002870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054002871 putative active site [active] 585054002872 heme pocket [chemical binding]; other site 585054002873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054002874 dimer interface [polypeptide binding]; other site 585054002875 phosphorylation site [posttranslational modification] 585054002876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054002877 ATP binding site [chemical binding]; other site 585054002878 Mg2+ binding site [ion binding]; other site 585054002879 G-X-G motif; other site 585054002880 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 585054002881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054002882 dimer interface [polypeptide binding]; other site 585054002883 phosphorylation site [posttranslational modification] 585054002884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054002885 ATP binding site [chemical binding]; other site 585054002886 Mg2+ binding site [ion binding]; other site 585054002887 G-X-G motif; other site 585054002888 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 585054002889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054002890 active site 585054002891 phosphorylation site [posttranslational modification] 585054002892 intermolecular recognition site; other site 585054002893 dimerization interface [polypeptide binding]; other site 585054002894 transcriptional regulator RcsB; Provisional; Region: PRK10840 585054002895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054002896 active site 585054002897 phosphorylation site [posttranslational modification] 585054002898 intermolecular recognition site; other site 585054002899 dimerization interface [polypeptide binding]; other site 585054002900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054002901 DNA binding residues [nucleotide binding] 585054002902 dimerization interface [polypeptide binding]; other site 585054002903 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 585054002904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054002905 ATP binding site [chemical binding]; other site 585054002906 G-X-G motif; other site 585054002907 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585054002908 putative binding surface; other site 585054002909 active site 585054002910 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054002911 outer membrane porin protein C; Provisional; Region: PRK10554 585054002912 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 585054002913 ApbE family; Region: ApbE; pfam02424 585054002914 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 585054002915 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 585054002916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054002917 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585054002918 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585054002919 DNA binding site [nucleotide binding] 585054002920 active site 585054002921 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 585054002922 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 585054002923 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 585054002924 Walker A/P-loop; other site 585054002925 ATP binding site [chemical binding]; other site 585054002926 Q-loop/lid; other site 585054002927 ABC transporter signature motif; other site 585054002928 Walker B; other site 585054002929 D-loop; other site 585054002930 H-loop/switch region; other site 585054002931 malate:quinone oxidoreductase; Validated; Region: PRK05257 585054002932 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 585054002933 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 585054002934 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585054002935 Walker A/P-loop; other site 585054002936 ATP binding site [chemical binding]; other site 585054002937 Q-loop/lid; other site 585054002938 ABC transporter signature motif; other site 585054002939 Walker B; other site 585054002940 D-loop; other site 585054002941 H-loop/switch region; other site 585054002942 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054002943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054002944 dimer interface [polypeptide binding]; other site 585054002945 conserved gate region; other site 585054002946 putative PBP binding loops; other site 585054002947 ABC-ATPase subunit interface; other site 585054002948 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 585054002949 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054002950 substrate binding pocket [chemical binding]; other site 585054002951 membrane-bound complex binding site; other site 585054002952 hinge residues; other site 585054002953 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 585054002954 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 585054002955 dimerization interface [polypeptide binding]; other site 585054002956 DPS ferroxidase diiron center [ion binding]; other site 585054002957 ion pore; other site 585054002958 threonine and homoserine efflux system; Provisional; Region: PRK10532 585054002959 EamA-like transporter family; Region: EamA; pfam00892 585054002960 outer membrane protein X; Provisional; Region: ompX; PRK09408 585054002961 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585054002962 Sulfatase; Region: Sulfatase; pfam00884 585054002963 manganese transport regulator MntR; Provisional; Region: PRK11050 585054002964 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585054002965 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 585054002966 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 585054002967 transmembrane helices; other site 585054002968 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585054002969 L,D-transpeptidase; Provisional; Region: PRK10260 585054002970 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054002971 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 585054002972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054002973 Walker A/P-loop; other site 585054002974 ATP binding site [chemical binding]; other site 585054002975 Q-loop/lid; other site 585054002976 ABC transporter signature motif; other site 585054002977 Walker B; other site 585054002978 D-loop; other site 585054002979 H-loop/switch region; other site 585054002980 ABC transporter; Region: ABC_tran_2; pfam12848 585054002981 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585054002982 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 585054002983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054002984 active site 585054002985 motif I; other site 585054002986 motif II; other site 585054002987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054002988 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585054002989 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585054002990 dimer interface [polypeptide binding]; other site 585054002991 active site 585054002992 glycine loop; other site 585054002993 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585054002994 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585054002995 active site 585054002996 intersubunit interactions; other site 585054002997 catalytic residue [active] 585054002998 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 585054002999 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585054003000 ATP binding site [chemical binding]; other site 585054003001 substrate interface [chemical binding]; other site 585054003002 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 585054003003 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 585054003004 dimer interface [polypeptide binding]; other site 585054003005 putative functional site; other site 585054003006 putative MPT binding site; other site 585054003007 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 585054003008 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054003009 Walker A/P-loop; other site 585054003010 ATP binding site [chemical binding]; other site 585054003011 Q-loop/lid; other site 585054003012 ABC transporter signature motif; other site 585054003013 Walker B; other site 585054003014 D-loop; other site 585054003015 H-loop/switch region; other site 585054003016 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585054003017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054003018 Walker A/P-loop; other site 585054003019 ATP binding site [chemical binding]; other site 585054003020 Q-loop/lid; other site 585054003021 ABC transporter signature motif; other site 585054003022 Walker B; other site 585054003023 D-loop; other site 585054003024 H-loop/switch region; other site 585054003025 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585054003026 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 585054003027 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 585054003028 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 585054003029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003030 dimer interface [polypeptide binding]; other site 585054003031 conserved gate region; other site 585054003032 putative PBP binding loops; other site 585054003033 ABC-ATPase subunit interface; other site 585054003034 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 585054003035 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585054003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003037 dimer interface [polypeptide binding]; other site 585054003038 conserved gate region; other site 585054003039 putative PBP binding loops; other site 585054003040 ABC-ATPase subunit interface; other site 585054003041 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 585054003042 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054003043 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054003044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054003045 metal binding site [ion binding]; metal-binding site 585054003046 active site 585054003047 I-site; other site 585054003048 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 585054003049 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585054003050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054003051 FeS/SAM binding site; other site 585054003052 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 585054003053 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 585054003054 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 585054003055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585054003056 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 585054003057 putative C-terminal domain interface [polypeptide binding]; other site 585054003058 putative GSH binding site (G-site) [chemical binding]; other site 585054003059 putative dimer interface [polypeptide binding]; other site 585054003060 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 585054003061 putative N-terminal domain interface [polypeptide binding]; other site 585054003062 putative dimer interface [polypeptide binding]; other site 585054003063 putative substrate binding pocket (H-site) [chemical binding]; other site 585054003064 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 585054003065 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585054003066 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585054003067 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 585054003068 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585054003069 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585054003070 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585054003071 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 585054003072 active site 585054003073 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 585054003074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054003075 putative substrate translocation pore; other site 585054003076 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 585054003077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054003078 active site 585054003079 motif I; other site 585054003080 motif II; other site 585054003081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054003082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054003083 putative substrate translocation pore; other site 585054003084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585054003085 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 585054003086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054003087 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585054003088 putative transporter; Provisional; Region: PRK04972 585054003089 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585054003090 TrkA-C domain; Region: TrkA_C; pfam02080 585054003091 TrkA-C domain; Region: TrkA_C; pfam02080 585054003092 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585054003093 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 585054003094 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 585054003095 dimer interface [polypeptide binding]; other site 585054003096 FMN binding site [chemical binding]; other site 585054003097 NADPH bind site [chemical binding]; other site 585054003098 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 585054003099 RimK-like ATP-grasp domain; Region: RimK; pfam08443 585054003100 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 585054003101 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 585054003102 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585054003103 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 585054003104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054003105 Walker A/P-loop; other site 585054003106 ATP binding site [chemical binding]; other site 585054003107 Q-loop/lid; other site 585054003108 ABC transporter signature motif; other site 585054003109 Walker B; other site 585054003110 D-loop; other site 585054003111 H-loop/switch region; other site 585054003112 TOBE domain; Region: TOBE_2; pfam08402 585054003113 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585054003114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003115 dimer interface [polypeptide binding]; other site 585054003116 conserved gate region; other site 585054003117 putative PBP binding loops; other site 585054003118 ABC-ATPase subunit interface; other site 585054003119 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585054003120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003121 putative PBP binding loops; other site 585054003122 dimer interface [polypeptide binding]; other site 585054003123 ABC-ATPase subunit interface; other site 585054003124 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 585054003125 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 585054003126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003127 S-adenosylmethionine binding site [chemical binding]; other site 585054003128 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585054003129 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054003130 substrate binding pocket [chemical binding]; other site 585054003131 membrane-bound complex binding site; other site 585054003132 hinge residues; other site 585054003133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003134 dimer interface [polypeptide binding]; other site 585054003135 conserved gate region; other site 585054003136 putative PBP binding loops; other site 585054003137 ABC-ATPase subunit interface; other site 585054003138 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054003139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003140 dimer interface [polypeptide binding]; other site 585054003141 conserved gate region; other site 585054003142 putative PBP binding loops; other site 585054003143 ABC-ATPase subunit interface; other site 585054003144 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585054003145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054003146 substrate binding pocket [chemical binding]; other site 585054003147 membrane-bound complex binding site; other site 585054003148 hinge residues; other site 585054003149 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 585054003150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054003151 Walker A/P-loop; other site 585054003152 ATP binding site [chemical binding]; other site 585054003153 Q-loop/lid; other site 585054003154 ABC transporter signature motif; other site 585054003155 Walker B; other site 585054003156 D-loop; other site 585054003157 H-loop/switch region; other site 585054003158 putative lipoprotein; Provisional; Region: PRK10533 585054003159 hypothetical protein; Provisional; Region: PRK02877 585054003160 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585054003161 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585054003162 amidase catalytic site [active] 585054003163 Zn binding residues [ion binding]; other site 585054003164 substrate binding site [chemical binding]; other site 585054003165 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585054003166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054003167 NAD(P) binding site [chemical binding]; other site 585054003168 active site 585054003169 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585054003170 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 585054003171 putative NAD(P) binding site [chemical binding]; other site 585054003172 putative active site [active] 585054003173 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 585054003174 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 585054003175 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 585054003176 tetramer interface [polypeptide binding]; other site 585054003177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054003178 catalytic residue [active] 585054003179 pyruvate dehydrogenase; Provisional; Region: PRK09124 585054003180 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 585054003181 PYR/PP interface [polypeptide binding]; other site 585054003182 dimer interface [polypeptide binding]; other site 585054003183 tetramer interface [polypeptide binding]; other site 585054003184 TPP binding site [chemical binding]; other site 585054003185 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585054003186 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 585054003187 TPP-binding site [chemical binding]; other site 585054003188 DoxX; Region: DoxX; pfam07681 585054003189 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 585054003190 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 585054003191 FAD binding pocket [chemical binding]; other site 585054003192 FAD binding motif [chemical binding]; other site 585054003193 phosphate binding motif [ion binding]; other site 585054003194 beta-alpha-beta structure motif; other site 585054003195 NAD binding pocket [chemical binding]; other site 585054003196 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054003197 catalytic loop [active] 585054003198 iron binding site [ion binding]; other site 585054003199 hybrid cluster protein; Provisional; Region: PRK05290 585054003200 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585054003201 ACS interaction site; other site 585054003202 CODH interaction site; other site 585054003203 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 585054003204 hybrid metal cluster; other site 585054003205 Predicted membrane protein [Function unknown]; Region: COG2431 585054003206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585054003207 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585054003208 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585054003209 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585054003210 amphipathic channel; other site 585054003211 Asn-Pro-Ala signature motifs; other site 585054003212 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 585054003213 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 585054003214 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585054003215 putative active site [active] 585054003216 putative metal-binding site [ion binding]; other site 585054003217 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585054003218 macrolide transporter subunit MacA; Provisional; Region: PRK11578 585054003219 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054003220 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054003221 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 585054003222 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585054003223 Walker A/P-loop; other site 585054003224 ATP binding site [chemical binding]; other site 585054003225 Q-loop/lid; other site 585054003226 ABC transporter signature motif; other site 585054003227 Walker B; other site 585054003228 D-loop; other site 585054003229 H-loop/switch region; other site 585054003230 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585054003231 FtsX-like permease family; Region: FtsX; pfam02687 585054003232 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054003233 DNA-binding site [nucleotide binding]; DNA binding site 585054003234 RNA-binding motif; other site 585054003235 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 585054003236 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 585054003237 Clp amino terminal domain; Region: Clp_N; pfam02861 585054003238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054003239 Walker A motif; other site 585054003240 ATP binding site [chemical binding]; other site 585054003241 Walker B motif; other site 585054003242 arginine finger; other site 585054003243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054003244 Walker A motif; other site 585054003245 ATP binding site [chemical binding]; other site 585054003246 Walker B motif; other site 585054003247 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585054003248 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054003249 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 585054003250 rRNA binding site [nucleotide binding]; other site 585054003251 predicted 30S ribosome binding site; other site 585054003252 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 585054003253 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 585054003254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054003255 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 585054003256 Walker A/P-loop; other site 585054003257 ATP binding site [chemical binding]; other site 585054003258 Q-loop/lid; other site 585054003259 ABC transporter signature motif; other site 585054003260 Walker B; other site 585054003261 D-loop; other site 585054003262 H-loop/switch region; other site 585054003263 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 585054003264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054003265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054003266 Walker A/P-loop; other site 585054003267 ATP binding site [chemical binding]; other site 585054003268 Q-loop/lid; other site 585054003269 ABC transporter signature motif; other site 585054003270 Walker B; other site 585054003271 D-loop; other site 585054003272 H-loop/switch region; other site 585054003273 thioredoxin reductase; Provisional; Region: PRK10262 585054003274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054003275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054003276 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 585054003277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054003278 putative DNA binding site [nucleotide binding]; other site 585054003279 putative Zn2+ binding site [ion binding]; other site 585054003280 AsnC family; Region: AsnC_trans_reg; pfam01037 585054003281 DNA translocase FtsK; Provisional; Region: PRK10263 585054003282 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 585054003283 DNA translocase FtsK; Provisional; Region: PRK10263 585054003284 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585054003285 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 585054003286 periplasmic chaperone LolA; Region: lolA; TIGR00547 585054003287 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 585054003288 recombination factor protein RarA; Reviewed; Region: PRK13342 585054003289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054003290 Walker A motif; other site 585054003291 ATP binding site [chemical binding]; other site 585054003292 Walker B motif; other site 585054003293 arginine finger; other site 585054003294 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 585054003295 seryl-tRNA synthetase; Provisional; Region: PRK05431 585054003296 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 585054003297 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 585054003298 dimer interface [polypeptide binding]; other site 585054003299 active site 585054003300 motif 1; other site 585054003301 motif 2; other site 585054003302 motif 3; other site 585054003303 Isochorismatase family; Region: Isochorismatase; pfam00857 585054003304 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 585054003305 catalytic triad [active] 585054003306 dimer interface [polypeptide binding]; other site 585054003307 conserved cis-peptide bond; other site 585054003308 putative MFS family transporter protein; Provisional; Region: PRK03633 585054003309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054003310 putative substrate translocation pore; other site 585054003311 inner membrane transporter YjeM; Provisional; Region: PRK15238 585054003312 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 585054003313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054003314 FeS/SAM binding site; other site 585054003315 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585054003316 Pyruvate formate lyase 1; Region: PFL1; cd01678 585054003317 coenzyme A binding site [chemical binding]; other site 585054003318 active site 585054003319 catalytic residues [active] 585054003320 glycine loop; other site 585054003321 formate transporter; Provisional; Region: PRK10805 585054003322 uncharacterized domain; Region: TIGR00702 585054003323 YcaO-like family; Region: YcaO; pfam02624 585054003324 Predicted membrane protein [Function unknown]; Region: COG2323 585054003325 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 585054003326 homodimer interface [polypeptide binding]; other site 585054003327 substrate-cofactor binding pocket; other site 585054003328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054003329 catalytic residue [active] 585054003330 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 585054003331 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 585054003332 hinge; other site 585054003333 active site 585054003334 cytidylate kinase; Provisional; Region: cmk; PRK00023 585054003335 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 585054003336 CMP-binding site; other site 585054003337 The sites determining sugar specificity; other site 585054003338 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 585054003339 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 585054003340 RNA binding site [nucleotide binding]; other site 585054003341 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 585054003342 RNA binding site [nucleotide binding]; other site 585054003343 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 585054003344 RNA binding site [nucleotide binding]; other site 585054003345 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 585054003346 RNA binding site [nucleotide binding]; other site 585054003347 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 585054003348 RNA binding site [nucleotide binding]; other site 585054003349 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585054003350 IHF dimer interface [polypeptide binding]; other site 585054003351 IHF - DNA interface [nucleotide binding]; other site 585054003352 ComEC family competence protein; Provisional; Region: PRK11539 585054003353 Competence protein; Region: Competence; pfam03772 585054003354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 585054003355 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 585054003356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054003357 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 585054003358 Walker A/P-loop; other site 585054003359 ATP binding site [chemical binding]; other site 585054003360 Q-loop/lid; other site 585054003361 ABC transporter signature motif; other site 585054003362 Walker B; other site 585054003363 D-loop; other site 585054003364 H-loop/switch region; other site 585054003365 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 585054003366 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 585054003367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 585054003368 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 585054003369 hypothetical protein; Provisional; Region: PRK11827 585054003370 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 585054003371 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 585054003372 Ligand binding site; other site 585054003373 oligomer interface; other site 585054003374 hypothetical protein; Provisional; Region: PRK10593 585054003375 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585054003376 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585054003377 putative active site [active] 585054003378 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585054003379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003380 S-adenosylmethionine binding site [chemical binding]; other site 585054003381 condesin subunit F; Provisional; Region: PRK05260 585054003382 condesin subunit E; Provisional; Region: PRK05256 585054003383 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 585054003384 MukB N-terminal; Region: MukB; pfam04310 585054003385 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 585054003386 murein L,D-transpeptidase; Provisional; Region: PRK10594 585054003387 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 585054003388 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054003389 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054003390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 585054003391 Peptidase M15; Region: Peptidase_M15_3; cl01194 585054003392 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 585054003393 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585054003394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054003395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054003396 homodimer interface [polypeptide binding]; other site 585054003397 catalytic residue [active] 585054003398 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054003399 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585054003400 trimer interface [polypeptide binding]; other site 585054003401 eyelet of channel; other site 585054003402 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 585054003403 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 585054003404 putative dimer interface [polypeptide binding]; other site 585054003405 putative anticodon binding site; other site 585054003406 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 585054003407 homodimer interface [polypeptide binding]; other site 585054003408 motif 1; other site 585054003409 motif 2; other site 585054003410 active site 585054003411 motif 3; other site 585054003412 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 585054003413 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 585054003414 active site 585054003415 aminopeptidase N; Provisional; Region: pepN; PRK14015 585054003416 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 585054003417 active site 585054003418 Zn binding site [ion binding]; other site 585054003419 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 585054003420 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585054003421 Walker A/P-loop; other site 585054003422 ATP binding site [chemical binding]; other site 585054003423 Q-loop/lid; other site 585054003424 ABC transporter signature motif; other site 585054003425 Walker B; other site 585054003426 D-loop; other site 585054003427 H-loop/switch region; other site 585054003428 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585054003429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003430 dimer interface [polypeptide binding]; other site 585054003431 conserved gate region; other site 585054003432 putative PBP binding loops; other site 585054003433 ABC-ATPase subunit interface; other site 585054003434 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 585054003435 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585054003436 active site 585054003437 dimer interface [polypeptide binding]; other site 585054003438 non-prolyl cis peptide bond; other site 585054003439 insertion regions; other site 585054003440 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 585054003441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054003442 substrate binding pocket [chemical binding]; other site 585054003443 membrane-bound complex binding site; other site 585054003444 hinge residues; other site 585054003445 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 585054003446 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585054003447 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 585054003448 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 585054003449 quinone interaction residues [chemical binding]; other site 585054003450 active site 585054003451 catalytic residues [active] 585054003452 FMN binding site [chemical binding]; other site 585054003453 substrate binding site [chemical binding]; other site 585054003454 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 585054003455 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 585054003456 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 585054003457 MOSC domain; Region: MOSC; pfam03473 585054003458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054003459 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585054003460 catalytic loop [active] 585054003461 iron binding site [ion binding]; other site 585054003462 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 585054003463 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 585054003464 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 585054003465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003466 S-adenosylmethionine binding site [chemical binding]; other site 585054003467 ABC transporter ATPase component; Reviewed; Region: PRK11147 585054003468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054003469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054003470 Walker A/P-loop; other site 585054003471 Walker A/P-loop; other site 585054003472 ATP binding site [chemical binding]; other site 585054003473 ATP binding site [chemical binding]; other site 585054003474 Q-loop/lid; other site 585054003475 Q-loop/lid; other site 585054003476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585054003477 ABC transporter signature motif; other site 585054003478 Walker B; other site 585054003479 D-loop; other site 585054003480 ABC transporter; Region: ABC_tran_2; pfam12848 585054003481 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585054003482 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 585054003483 Paraquat-inducible protein A; Region: PqiA; pfam04403 585054003484 Paraquat-inducible protein A; Region: PqiA; pfam04403 585054003485 paraquat-inducible protein B; Provisional; Region: PRK10807 585054003486 mce related protein; Region: MCE; pfam02470 585054003487 mce related protein; Region: MCE; pfam02470 585054003488 mce related protein; Region: MCE; pfam02470 585054003489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 585054003490 Protein of unknown function (DUF330); Region: DUF330; pfam03886 585054003491 ribosome modulation factor; Provisional; Region: PRK14563 585054003492 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 585054003493 active site 1 [active] 585054003494 dimer interface [polypeptide binding]; other site 585054003495 active site 2 [active] 585054003496 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 585054003497 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585054003498 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 585054003499 outer membrane protein A; Reviewed; Region: PRK10808 585054003500 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 585054003501 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585054003502 ligand binding site [chemical binding]; other site 585054003503 Cell division inhibitor SulA; Region: SulA; cl01880 585054003504 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 585054003505 TfoX C-terminal domain; Region: TfoX_C; pfam04994 585054003506 TIGR01666 family membrane protein; Region: YCCS 585054003507 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585054003508 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585054003509 Predicted membrane protein [Function unknown]; Region: COG3304 585054003510 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585054003511 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585054003512 DNA helicase IV; Provisional; Region: helD; PRK11054 585054003513 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 585054003514 Part of AAA domain; Region: AAA_19; pfam13245 585054003515 Family description; Region: UvrD_C_2; pfam13538 585054003516 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 585054003517 active site 585054003518 dimer interfaces [polypeptide binding]; other site 585054003519 catalytic residues [active] 585054003520 hypothetical protein; Provisional; Region: PRK03641 585054003521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 585054003522 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 585054003523 heat shock protein HspQ; Provisional; Region: PRK14129 585054003524 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 585054003525 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 585054003526 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 585054003527 putative RNA binding site [nucleotide binding]; other site 585054003528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003529 S-adenosylmethionine binding site [chemical binding]; other site 585054003530 acylphosphatase; Provisional; Region: PRK14439 585054003531 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 585054003532 sulfur transfer protein TusE; Provisional; Region: PRK11508 585054003533 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585054003534 YccA-like proteins; Region: YccA_like; cd10433 585054003535 Leucine rich repeat; Region: LRR_8; pfam13855 585054003536 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 585054003537 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585054003538 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585054003539 hydrogenase 1 large subunit; Provisional; Region: PRK10170 585054003540 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585054003541 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 585054003542 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585054003543 putative substrate-binding site; other site 585054003544 nickel binding site [ion binding]; other site 585054003545 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 585054003546 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585054003547 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585054003548 hypothetical protein; Provisional; Region: PRK10396 585054003549 yecA family protein; Region: ygfB_yecA; TIGR02292 585054003550 SEC-C motif; Region: SEC-C; pfam02810 585054003551 tyrosine transporter TyrP; Provisional; Region: PRK15132 585054003552 aromatic amino acid transport protein; Region: araaP; TIGR00837 585054003553 probable metal-binding protein; Region: matur_matur; TIGR03853 585054003554 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585054003555 Ferritin-like domain; Region: Ferritin; pfam00210 585054003556 ferroxidase diiron center [ion binding]; other site 585054003557 YecR-like lipoprotein; Region: YecR; pfam13992 585054003558 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585054003559 Ferritin-like domain; Region: Ferritin; pfam00210 585054003560 ferroxidase diiron center [ion binding]; other site 585054003561 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585054003562 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 585054003563 ligand binding site [chemical binding]; other site 585054003564 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 585054003565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585054003566 Walker A/P-loop; other site 585054003567 ATP binding site [chemical binding]; other site 585054003568 Q-loop/lid; other site 585054003569 ABC transporter signature motif; other site 585054003570 Walker B; other site 585054003571 D-loop; other site 585054003572 H-loop/switch region; other site 585054003573 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054003574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054003575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054003576 TM-ABC transporter signature motif; other site 585054003577 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 585054003578 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 585054003579 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 585054003580 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 585054003581 active site 585054003582 homotetramer interface [polypeptide binding]; other site 585054003583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054003584 Ligand Binding Site [chemical binding]; other site 585054003585 transcriptional activator FlhD; Provisional; Region: PRK02909 585054003586 transcriptional activator FlhC; Provisional; Region: PRK12722 585054003587 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 585054003588 flagellar motor protein MotA; Validated; Region: PRK09110 585054003589 flagellar motor protein MotB; Validated; Region: motB; PRK09041 585054003590 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 585054003591 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585054003592 ligand binding site [chemical binding]; other site 585054003593 chemotaxis protein CheA; Provisional; Region: PRK10547 585054003594 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585054003595 putative binding surface; other site 585054003596 active site 585054003597 CheY binding; Region: CheY-binding; pfam09078 585054003598 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 585054003599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054003600 ATP binding site [chemical binding]; other site 585054003601 Mg2+ binding site [ion binding]; other site 585054003602 G-X-G motif; other site 585054003603 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 585054003604 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 585054003605 putative CheA interaction surface; other site 585054003606 Spore Coat Protein U domain; Region: SCPU; pfam05229 585054003607 Spore Coat Protein U domain; Region: SCPU; pfam05229 585054003608 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585054003609 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054003610 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 585054003611 PapC N-terminal domain; Region: PapC_N; pfam13954 585054003612 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054003613 PapC C-terminal domain; Region: PapC_C; pfam13953 585054003614 Spore Coat Protein U domain; Region: SCPU; cl02253 585054003615 Spore Coat Protein U domain; Region: SCPU; pfam05229 585054003616 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585054003617 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585054003618 dimer interface [polypeptide binding]; other site 585054003619 ligand binding site [chemical binding]; other site 585054003620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054003621 dimerization interface [polypeptide binding]; other site 585054003622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585054003623 dimer interface [polypeptide binding]; other site 585054003624 putative CheW interface [polypeptide binding]; other site 585054003625 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 585054003626 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 585054003627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003628 S-adenosylmethionine binding site [chemical binding]; other site 585054003629 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 585054003630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054003631 active site 585054003632 phosphorylation site [posttranslational modification] 585054003633 intermolecular recognition site; other site 585054003634 dimerization interface [polypeptide binding]; other site 585054003635 CheB methylesterase; Region: CheB_methylest; pfam01339 585054003636 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 585054003637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054003638 active site 585054003639 phosphorylation site [posttranslational modification] 585054003640 intermolecular recognition site; other site 585054003641 dimerization interface [polypeptide binding]; other site 585054003642 chemotaxis regulator CheZ; Provisional; Region: PRK11166 585054003643 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 585054003644 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 585054003645 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 585054003646 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585054003647 HSP70 interaction site [polypeptide binding]; other site 585054003648 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585054003649 substrate binding site [polypeptide binding]; other site 585054003650 dimer interface [polypeptide binding]; other site 585054003651 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 585054003652 homotrimer interaction site [polypeptide binding]; other site 585054003653 putative active site [active] 585054003654 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 585054003655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054003656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054003657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054003658 dimerization interface [polypeptide binding]; other site 585054003659 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 585054003660 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585054003661 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585054003662 catalytic core [active] 585054003663 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585054003664 hypothetical protein; Provisional; Region: PRK10174 585054003665 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 585054003666 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585054003667 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054003668 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 585054003669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054003670 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 585054003671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054003672 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054003673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054003674 metal binding site [ion binding]; metal-binding site 585054003675 active site 585054003676 I-site; other site 585054003677 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 585054003678 Cellulose synthase-like protein; Region: PLN02893 585054003679 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 585054003680 DXD motif; other site 585054003681 PilZ domain; Region: PilZ; pfam07238 585054003682 cellulose synthase regulator protein; Provisional; Region: PRK11114 585054003683 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 585054003684 CPxP motif; other site 585054003685 putative inner membrane protein; Provisional; Region: PRK11099 585054003686 lipoprotein; Provisional; Region: PRK10397 585054003687 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 585054003688 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 585054003689 active site 585054003690 Na/Ca binding site [ion binding]; other site 585054003691 catalytic site [active] 585054003692 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 585054003693 flagellar protein FliS; Validated; Region: fliS; PRK05685 585054003694 flagellar capping protein; Reviewed; Region: fliD; PRK08032 585054003695 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 585054003696 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 585054003697 flagellin; Validated; Region: PRK08026 585054003698 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585054003699 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 585054003700 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 585054003701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585054003702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585054003703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585054003704 DNA binding residues [nucleotide binding] 585054003705 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 585054003706 cystine transporter subunit; Provisional; Region: PRK11260 585054003707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054003708 substrate binding pocket [chemical binding]; other site 585054003709 membrane-bound complex binding site; other site 585054003710 hinge residues; other site 585054003711 D-cysteine desulfhydrase; Validated; Region: PRK03910 585054003712 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 585054003713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054003714 catalytic residue [active] 585054003715 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054003716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054003717 dimer interface [polypeptide binding]; other site 585054003718 conserved gate region; other site 585054003719 putative PBP binding loops; other site 585054003720 ABC-ATPase subunit interface; other site 585054003721 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 585054003722 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585054003723 Walker A/P-loop; other site 585054003724 ATP binding site [chemical binding]; other site 585054003725 Q-loop/lid; other site 585054003726 ABC transporter signature motif; other site 585054003727 Walker B; other site 585054003728 D-loop; other site 585054003729 H-loop/switch region; other site 585054003730 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 585054003731 Autoinducer binding domain; Region: Autoind_bind; pfam03472 585054003732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054003733 DNA binding residues [nucleotide binding] 585054003734 dimerization interface [polypeptide binding]; other site 585054003735 hypothetical protein; Provisional; Region: PRK10613 585054003736 response regulator; Provisional; Region: PRK09483 585054003737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054003738 active site 585054003739 phosphorylation site [posttranslational modification] 585054003740 intermolecular recognition site; other site 585054003741 dimerization interface [polypeptide binding]; other site 585054003742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054003743 DNA binding residues [nucleotide binding] 585054003744 dimerization interface [polypeptide binding]; other site 585054003745 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 585054003746 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585054003747 GIY-YIG motif/motif A; other site 585054003748 active site 585054003749 catalytic site [active] 585054003750 putative DNA binding site [nucleotide binding]; other site 585054003751 metal binding site [ion binding]; metal-binding site 585054003752 UvrB/uvrC motif; Region: UVR; pfam02151 585054003753 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 585054003754 Helix-hairpin-helix motif; Region: HHH; pfam00633 585054003755 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 585054003756 voltage-gated potassium channel; Provisional; Region: PRK10537 585054003757 Ion channel; Region: Ion_trans_2; pfam07885 585054003758 TrkA-N domain; Region: TrkA_N; pfam02254 585054003759 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 585054003760 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585054003761 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 585054003762 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 585054003763 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 585054003764 HAMP domain; Region: HAMP; pfam00672 585054003765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054003766 dimer interface [polypeptide binding]; other site 585054003767 phosphorylation site [posttranslational modification] 585054003768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054003769 ATP binding site [chemical binding]; other site 585054003770 Mg2+ binding site [ion binding]; other site 585054003771 G-X-G motif; other site 585054003772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054003773 active site 585054003774 phosphorylation site [posttranslational modification] 585054003775 intermolecular recognition site; other site 585054003776 dimerization interface [polypeptide binding]; other site 585054003777 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585054003778 putative binding surface; other site 585054003779 active site 585054003780 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 585054003781 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 585054003782 putative ligand binding site [chemical binding]; other site 585054003783 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 585054003784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054003785 active site 585054003786 phosphorylation site [posttranslational modification] 585054003787 intermolecular recognition site; other site 585054003788 dimerization interface [polypeptide binding]; other site 585054003789 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054003790 DNA binding site [nucleotide binding] 585054003791 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 585054003792 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585054003793 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 585054003794 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585054003795 molybdopterin cofactor binding site [chemical binding]; other site 585054003796 substrate binding site [chemical binding]; other site 585054003797 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585054003798 molybdopterin cofactor binding site; other site 585054003799 chaperone protein TorD; Validated; Region: torD; PRK04976 585054003800 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 585054003801 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 585054003802 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 585054003803 FHIPEP family; Region: FHIPEP; pfam00771 585054003804 Flagellar protein FlhE; Region: FlhE; pfam06366 585054003805 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 585054003806 arginyl-tRNA synthetase; Region: argS; TIGR00456 585054003807 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 585054003808 active site 585054003809 HIGH motif; other site 585054003810 KMSK motif region; other site 585054003811 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 585054003812 tRNA binding surface [nucleotide binding]; other site 585054003813 anticodon binding site; other site 585054003814 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 585054003815 putative metal binding site [ion binding]; other site 585054003816 copper homeostasis protein CutC; Provisional; Region: PRK11572 585054003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003818 S-adenosylmethionine binding site [chemical binding]; other site 585054003819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003820 S-adenosylmethionine binding site [chemical binding]; other site 585054003821 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 585054003822 hypothetical protein; Provisional; Region: PRK10302 585054003823 Isochorismatase family; Region: Isochorismatase; pfam00857 585054003824 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585054003825 catalytic triad [active] 585054003826 conserved cis-peptide bond; other site 585054003827 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 585054003828 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 585054003829 dimer interface [polypeptide binding]; other site 585054003830 anticodon binding site; other site 585054003831 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585054003832 homodimer interface [polypeptide binding]; other site 585054003833 motif 1; other site 585054003834 active site 585054003835 motif 2; other site 585054003836 GAD domain; Region: GAD; pfam02938 585054003837 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585054003838 motif 3; other site 585054003839 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 585054003840 nudix motif; other site 585054003841 hypothetical protein; Validated; Region: PRK00110 585054003842 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 585054003843 active site 585054003844 putative DNA-binding cleft [nucleotide binding]; other site 585054003845 dimer interface [polypeptide binding]; other site 585054003846 hypothetical protein; Provisional; Region: PRK11470 585054003847 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 585054003848 RuvA N terminal domain; Region: RuvA_N; pfam01330 585054003849 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 585054003850 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 585054003851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054003852 Walker A motif; other site 585054003853 ATP binding site [chemical binding]; other site 585054003854 Walker B motif; other site 585054003855 arginine finger; other site 585054003856 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 585054003857 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585054003858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585054003859 ABC-ATPase subunit interface; other site 585054003860 dimer interface [polypeptide binding]; other site 585054003861 putative PBP binding regions; other site 585054003862 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 585054003863 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585054003864 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 585054003865 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 585054003866 metal binding site [ion binding]; metal-binding site 585054003867 putative peptidase; Provisional; Region: PRK11649 585054003868 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 585054003869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054003870 Peptidase family M23; Region: Peptidase_M23; pfam01551 585054003871 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585054003872 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585054003873 putative acyl-acceptor binding pocket; other site 585054003874 pyruvate kinase; Provisional; Region: PRK05826 585054003875 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 585054003876 domain interfaces; other site 585054003877 active site 585054003878 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 585054003879 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585054003880 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585054003881 putative active site [active] 585054003882 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 585054003883 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 585054003884 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 585054003885 phosphogluconate dehydratase; Validated; Region: PRK09054 585054003886 6-phosphogluconate dehydratase; Region: edd; TIGR01196 585054003887 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 585054003888 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585054003889 active site 585054003890 intersubunit interface [polypeptide binding]; other site 585054003891 catalytic residue [active] 585054003892 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 585054003893 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585054003894 ATP-grasp domain; Region: ATP-grasp; pfam02222 585054003895 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 585054003896 hypothetical protein; Provisional; Region: PRK13680 585054003897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 585054003898 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 585054003899 putative metal binding site [ion binding]; other site 585054003900 protease 2; Provisional; Region: PRK10115 585054003901 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585054003902 exodeoxyribonuclease X; Provisional; Region: PRK07983 585054003903 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585054003904 active site 585054003905 catalytic site [active] 585054003906 substrate binding site [chemical binding]; other site 585054003907 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585054003908 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 585054003909 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 585054003910 hypothetical protein; Provisional; Region: PRK10301 585054003911 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 585054003912 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 585054003913 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 585054003914 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585054003915 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585054003916 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 585054003917 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 585054003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003919 S-adenosylmethionine binding site [chemical binding]; other site 585054003920 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 585054003921 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 585054003922 mce related protein; Region: MCE; pfam02470 585054003923 mce related protein; Region: MCE; pfam02470 585054003924 mce related protein; Region: MCE; pfam02470 585054003925 mce related protein; Region: MCE; pfam02470 585054003926 mce related protein; Region: MCE; pfam02470 585054003927 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 585054003928 Paraquat-inducible protein A; Region: PqiA; pfam04403 585054003929 Paraquat-inducible protein A; Region: PqiA; pfam04403 585054003930 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 585054003931 GAF domain; Region: GAF_2; pfam13185 585054003932 ProP expression regulator; Provisional; Region: PRK04950 585054003933 ProQ/FINO family; Region: ProQ; pfam04352 585054003934 carboxy-terminal protease; Provisional; Region: PRK11186 585054003935 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 585054003936 protein binding site [polypeptide binding]; other site 585054003937 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 585054003938 Catalytic dyad [active] 585054003939 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 585054003940 heat shock protein HtpX; Provisional; Region: PRK05457 585054003941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054003942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585054003943 putative substrate translocation pore; other site 585054003944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054003945 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 585054003946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054003947 dimerization interface [polypeptide binding]; other site 585054003948 putative Zn2+ binding site [ion binding]; other site 585054003949 putative DNA binding site [nucleotide binding]; other site 585054003950 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054003951 YobH-like protein; Region: YobH; pfam13996 585054003952 PhoPQ regulatory protein; Provisional; Region: PRK10299 585054003953 YebO-like protein; Region: YebO; pfam13974 585054003954 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 585054003955 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054003956 DNA-binding site [nucleotide binding]; DNA binding site 585054003957 RNA-binding motif; other site 585054003958 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 585054003959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054003960 S-adenosylmethionine binding site [chemical binding]; other site 585054003961 hypothetical protein; Provisional; Region: PRK11469 585054003962 Domain of unknown function DUF; Region: DUF204; pfam02659 585054003963 Domain of unknown function DUF; Region: DUF204; pfam02659 585054003964 hypothetical protein; Provisional; Region: PRK02913 585054003965 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 585054003966 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585054003967 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 585054003968 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585054003969 active pocket/dimerization site; other site 585054003970 active site 585054003971 phosphorylation site [posttranslational modification] 585054003972 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585054003973 active site 585054003974 phosphorylation site [posttranslational modification] 585054003975 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585054003976 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585054003977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585054003978 Transporter associated domain; Region: CorC_HlyC; smart01091 585054003979 phage resistance protein; Provisional; Region: PRK10551 585054003980 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585054003981 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054003982 L-serine deaminase; Provisional; Region: PRK15023 585054003983 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585054003984 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585054003985 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 585054003986 putative active site [active] 585054003987 putative CoA binding site [chemical binding]; other site 585054003988 nudix motif; other site 585054003989 metal binding site [ion binding]; metal-binding site 585054003990 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 585054003991 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585054003992 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 585054003993 hypothetical protein; Provisional; Region: PRK05114 585054003994 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 585054003995 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 585054003996 homotrimer interaction site [polypeptide binding]; other site 585054003997 putative active site [active] 585054003998 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 585054003999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585054004000 ATP binding site [chemical binding]; other site 585054004001 DEAD_2; Region: DEAD_2; pfam06733 585054004002 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585054004003 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 585054004004 Glycoprotease family; Region: Peptidase_M22; pfam00814 585054004005 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 585054004006 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 585054004007 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 585054004008 acyl-activating enzyme (AAE) consensus motif; other site 585054004009 putative AMP binding site [chemical binding]; other site 585054004010 putative active site [active] 585054004011 putative CoA binding site [chemical binding]; other site 585054004012 ribonuclease D; Provisional; Region: PRK10829 585054004013 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 585054004014 catalytic site [active] 585054004015 putative active site [active] 585054004016 putative substrate binding site [chemical binding]; other site 585054004017 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585054004018 L,D-transpeptidase; Provisional; Region: PRK10260 585054004019 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054004020 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054004021 transcription-repair coupling factor; Provisional; Region: PRK10689 585054004022 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 585054004023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054004024 ATP binding site [chemical binding]; other site 585054004025 putative Mg++ binding site [ion binding]; other site 585054004026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054004027 nucleotide binding region [chemical binding]; other site 585054004028 ATP-binding site [chemical binding]; other site 585054004029 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 585054004030 Predicted membrane protein [Function unknown]; Region: COG4763 585054004031 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585054004032 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 585054004033 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585054004034 FtsX-like permease family; Region: FtsX; pfam02687 585054004035 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 585054004036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585054004037 Walker A/P-loop; other site 585054004038 ATP binding site [chemical binding]; other site 585054004039 Q-loop/lid; other site 585054004040 ABC transporter signature motif; other site 585054004041 Walker B; other site 585054004042 D-loop; other site 585054004043 H-loop/switch region; other site 585054004044 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 585054004045 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585054004046 FtsX-like permease family; Region: FtsX; pfam02687 585054004047 fructokinase; Reviewed; Region: PRK09557 585054004048 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054004049 nucleotide binding site [chemical binding]; other site 585054004050 NAD-dependent deacetylase; Provisional; Region: PRK00481 585054004051 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 585054004052 NAD+ binding site [chemical binding]; other site 585054004053 substrate binding site [chemical binding]; other site 585054004054 Zn binding site [ion binding]; other site 585054004055 Repair protein; Region: Repair_PSII; cl01535 585054004056 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 585054004057 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 585054004058 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 585054004059 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585054004060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004061 dimer interface [polypeptide binding]; other site 585054004062 conserved gate region; other site 585054004063 putative PBP binding loops; other site 585054004064 ABC-ATPase subunit interface; other site 585054004065 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585054004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004067 dimer interface [polypeptide binding]; other site 585054004068 conserved gate region; other site 585054004069 putative PBP binding loops; other site 585054004070 ABC-ATPase subunit interface; other site 585054004071 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 585054004072 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 585054004073 Walker A/P-loop; other site 585054004074 ATP binding site [chemical binding]; other site 585054004075 Q-loop/lid; other site 585054004076 ABC transporter signature motif; other site 585054004077 Walker B; other site 585054004078 D-loop; other site 585054004079 H-loop/switch region; other site 585054004080 TOBE domain; Region: TOBE_2; pfam08402 585054004081 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 585054004082 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 585054004083 metal binding site [ion binding]; metal-binding site 585054004084 dimer interface [polypeptide binding]; other site 585054004085 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 585054004086 active site 585054004087 phosphate binding residues; other site 585054004088 catalytic residues [active] 585054004089 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 585054004090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585054004091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585054004092 methionine sulfoxide reductase B; Provisional; Region: PRK00222 585054004093 SelR domain; Region: SelR; pfam01641 585054004094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 585054004095 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 585054004096 Isochorismatase family; Region: Isochorismatase; pfam00857 585054004097 catalytic triad [active] 585054004098 metal binding site [ion binding]; metal-binding site 585054004099 conserved cis-peptide bond; other site 585054004100 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 585054004101 active site 585054004102 homodimer interface [polypeptide binding]; other site 585054004103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 585054004104 protease 4; Provisional; Region: PRK10949 585054004105 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 585054004106 tandem repeat interface [polypeptide binding]; other site 585054004107 oligomer interface [polypeptide binding]; other site 585054004108 active site residues [active] 585054004109 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 585054004110 tandem repeat interface [polypeptide binding]; other site 585054004111 oligomer interface [polypeptide binding]; other site 585054004112 active site residues [active] 585054004113 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 585054004114 putative FMN binding site [chemical binding]; other site 585054004115 selenophosphate synthetase; Provisional; Region: PRK00943 585054004116 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 585054004117 dimerization interface [polypeptide binding]; other site 585054004118 putative ATP binding site [chemical binding]; other site 585054004119 DNA topoisomerase III; Provisional; Region: PRK07726 585054004120 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 585054004121 active site 585054004122 putative interdomain interaction site [polypeptide binding]; other site 585054004123 putative metal-binding site [ion binding]; other site 585054004124 putative nucleotide binding site [chemical binding]; other site 585054004125 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585054004126 domain I; other site 585054004127 DNA binding groove [nucleotide binding] 585054004128 phosphate binding site [ion binding]; other site 585054004129 domain II; other site 585054004130 domain III; other site 585054004131 nucleotide binding site [chemical binding]; other site 585054004132 catalytic site [active] 585054004133 domain IV; other site 585054004134 hypothetical protein; Provisional; Region: PRK11380 585054004135 glutamate dehydrogenase; Provisional; Region: PRK09414 585054004136 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 585054004137 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 585054004138 NAD(P) binding site [chemical binding]; other site 585054004139 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 585054004140 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585054004141 active site 585054004142 8-oxo-dGMP binding site [chemical binding]; other site 585054004143 nudix motif; other site 585054004144 metal binding site [ion binding]; metal-binding site 585054004145 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585054004146 Rhodanese Homology Domain; Region: RHOD; smart00450 585054004147 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 585054004148 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585054004149 active site residue [active] 585054004150 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585054004151 active site residue [active] 585054004152 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 585054004153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054004154 Walker A/P-loop; other site 585054004155 ATP binding site [chemical binding]; other site 585054004156 Q-loop/lid; other site 585054004157 ABC transporter signature motif; other site 585054004158 Walker B; other site 585054004159 D-loop; other site 585054004160 H-loop/switch region; other site 585054004161 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 585054004162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004163 putative PBP binding loops; other site 585054004164 ABC-ATPase subunit interface; other site 585054004165 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 585054004166 hypothetical protein; Provisional; Region: PRK11622 585054004167 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585054004168 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585054004169 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585054004170 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585054004171 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585054004172 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585054004173 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 585054004174 putative catalytic site [active] 585054004175 putative phosphate binding site [ion binding]; other site 585054004176 active site 585054004177 metal binding site A [ion binding]; metal-binding site 585054004178 DNA binding site [nucleotide binding] 585054004179 putative AP binding site [nucleotide binding]; other site 585054004180 putative metal binding site B [ion binding]; other site 585054004181 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 585054004182 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585054004183 inhibitor-cofactor binding pocket; inhibition site 585054004184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054004185 catalytic residue [active] 585054004186 arginine succinyltransferase; Provisional; Region: PRK10456 585054004187 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 585054004188 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 585054004189 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 585054004190 NAD(P) binding site [chemical binding]; other site 585054004191 catalytic residues [active] 585054004192 succinylarginine dihydrolase; Provisional; Region: PRK13281 585054004193 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 585054004194 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 585054004195 putative active site [active] 585054004196 Zn binding site [ion binding]; other site 585054004197 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585054004198 dimer interface [polypeptide binding]; other site 585054004199 hypothetical protein; Provisional; Region: PRK11396 585054004200 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 585054004201 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585054004202 GIY-YIG motif/motif A; other site 585054004203 active site 585054004204 catalytic site [active] 585054004205 putative DNA binding site [nucleotide binding]; other site 585054004206 metal binding site [ion binding]; metal-binding site 585054004207 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 585054004208 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 585054004209 homodimer interface [polypeptide binding]; other site 585054004210 NAD binding pocket [chemical binding]; other site 585054004211 ATP binding pocket [chemical binding]; other site 585054004212 Mg binding site [ion binding]; other site 585054004213 active-site loop [active] 585054004214 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 585054004215 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585054004216 active site 585054004217 P-loop; other site 585054004218 phosphorylation site [posttranslational modification] 585054004219 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 585054004220 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 585054004221 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585054004222 methionine cluster; other site 585054004223 active site 585054004224 phosphorylation site [posttranslational modification] 585054004225 metal binding site [ion binding]; metal-binding site 585054004226 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 585054004227 Cupin domain; Region: Cupin_2; pfam07883 585054004228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054004229 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585054004230 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 585054004231 NAD binding site [chemical binding]; other site 585054004232 sugar binding site [chemical binding]; other site 585054004233 divalent metal binding site [ion binding]; other site 585054004234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585054004235 dimer interface [polypeptide binding]; other site 585054004236 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 585054004237 putative active site [active] 585054004238 YdjC motif; other site 585054004239 Mg binding site [ion binding]; other site 585054004240 putative homodimer interface [polypeptide binding]; other site 585054004241 hydroperoxidase II; Provisional; Region: katE; PRK11249 585054004242 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 585054004243 tetramer interface [polypeptide binding]; other site 585054004244 heme binding pocket [chemical binding]; other site 585054004245 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 585054004246 domain interactions; other site 585054004247 cell division modulator; Provisional; Region: PRK10113 585054004248 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 585054004249 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585054004250 inner membrane protein; Provisional; Region: PRK11648 585054004251 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 585054004252 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585054004253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054004254 motif II; other site 585054004255 YniB-like protein; Region: YniB; pfam14002 585054004256 Phosphotransferase enzyme family; Region: APH; pfam01636 585054004257 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585054004258 active site 585054004259 ATP binding site [chemical binding]; other site 585054004260 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 585054004261 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585054004262 6-phosphofructokinase 2; Provisional; Region: PRK10294 585054004263 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585054004264 putative substrate binding site [chemical binding]; other site 585054004265 putative ATP binding site [chemical binding]; other site 585054004266 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 585054004267 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 585054004268 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 585054004269 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 585054004270 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 585054004271 active site 585054004272 dimer interface [polypeptide binding]; other site 585054004273 motif 1; other site 585054004274 motif 2; other site 585054004275 motif 3; other site 585054004276 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 585054004277 anticodon binding site; other site 585054004278 Evidence 7 : Gene remnant; Product type f : factor; fragment of protein chain initiation factor IF-3 (partial) 585054004279 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 585054004280 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 585054004281 23S rRNA binding site [nucleotide binding]; other site 585054004282 L21 binding site [polypeptide binding]; other site 585054004283 L13 binding site [polypeptide binding]; other site 585054004284 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 585054004285 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 585054004286 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 585054004287 dimer interface [polypeptide binding]; other site 585054004288 motif 1; other site 585054004289 active site 585054004290 motif 2; other site 585054004291 motif 3; other site 585054004292 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 585054004293 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 585054004294 putative tRNA-binding site [nucleotide binding]; other site 585054004295 B3/4 domain; Region: B3_4; pfam03483 585054004296 tRNA synthetase B5 domain; Region: B5; smart00874 585054004297 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 585054004298 dimer interface [polypeptide binding]; other site 585054004299 motif 1; other site 585054004300 motif 3; other site 585054004301 motif 2; other site 585054004302 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 585054004303 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585054004304 IHF dimer interface [polypeptide binding]; other site 585054004305 IHF - DNA interface [nucleotide binding]; other site 585054004306 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585054004307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585054004308 ABC-ATPase subunit interface; other site 585054004309 dimer interface [polypeptide binding]; other site 585054004310 putative PBP binding regions; other site 585054004311 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 585054004312 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585054004313 Walker A/P-loop; other site 585054004314 ATP binding site [chemical binding]; other site 585054004315 Q-loop/lid; other site 585054004316 ABC transporter signature motif; other site 585054004317 Walker B; other site 585054004318 D-loop; other site 585054004319 H-loop/switch region; other site 585054004320 NlpC/P60 family; Region: NLPC_P60; pfam00877 585054004321 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 585054004322 Uncharacterized conserved protein [Function unknown]; Region: COG0397 585054004323 hypothetical protein; Validated; Region: PRK00029 585054004324 Hemin uptake protein hemP; Region: hemP; cl10043 585054004325 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 585054004326 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585054004327 PEP synthetase regulatory protein; Provisional; Region: PRK05339 585054004328 phosphoenolpyruvate synthase; Validated; Region: PRK06464 585054004329 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 585054004330 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585054004331 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585054004332 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 585054004333 putative inner membrane protein; Provisional; Region: PRK10983 585054004334 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585054004335 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585054004336 FAD binding domain; Region: FAD_binding_4; pfam01565 585054004337 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585054004338 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585054004339 CoenzymeA binding site [chemical binding]; other site 585054004340 subunit interaction site [polypeptide binding]; other site 585054004341 PHB binding site; other site 585054004342 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054004343 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 585054004344 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 585054004345 putative ABC transporter; Region: ycf24; CHL00085 585054004346 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 585054004347 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 585054004348 Walker A/P-loop; other site 585054004349 ATP binding site [chemical binding]; other site 585054004350 Q-loop/lid; other site 585054004351 ABC transporter signature motif; other site 585054004352 Walker B; other site 585054004353 D-loop; other site 585054004354 H-loop/switch region; other site 585054004355 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 585054004356 FeS assembly protein SufD; Region: sufD; TIGR01981 585054004357 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585054004358 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585054004359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585054004360 catalytic residue [active] 585054004361 cysteine desufuration protein SufE; Provisional; Region: PRK09296 585054004362 L,D-transpeptidase; Provisional; Region: PRK10190 585054004363 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054004364 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054004365 murein lipoprotein; Provisional; Region: PRK15396 585054004366 pyruvate kinase; Provisional; Region: PRK09206 585054004367 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585054004368 domain interfaces; other site 585054004369 active site 585054004370 hypothetical protein; Provisional; Region: PRK10292 585054004371 hypothetical protein; Provisional; Region: PRK09897 585054004372 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 585054004373 putative monooxygenase; Provisional; Region: PRK11118 585054004374 multidrug efflux protein; Reviewed; Region: PRK01766 585054004375 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 585054004376 cation binding site [ion binding]; other site 585054004377 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 585054004378 Lumazine binding domain; Region: Lum_binding; pfam00677 585054004379 Lumazine binding domain; Region: Lum_binding; pfam00677 585054004380 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 585054004381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054004382 S-adenosylmethionine binding site [chemical binding]; other site 585054004383 putative transporter; Provisional; Region: PRK11043 585054004384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054004385 putative substrate translocation pore; other site 585054004386 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585054004387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054004388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054004389 dimerization interface [polypeptide binding]; other site 585054004390 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 585054004391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054004392 DNA binding site [nucleotide binding] 585054004393 domain linker motif; other site 585054004394 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585054004395 dimerization interface [polypeptide binding]; other site 585054004396 ligand binding site [chemical binding]; other site 585054004397 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585054004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054004399 putative substrate translocation pore; other site 585054004400 superoxide dismutase; Provisional; Region: PRK10543 585054004401 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585054004402 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585054004403 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585054004404 NlpC/P60 family; Region: NLPC_P60; pfam00877 585054004405 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 585054004406 putative GSH binding site [chemical binding]; other site 585054004407 catalytic residues [active] 585054004408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054004409 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 585054004410 ATP binding site [chemical binding]; other site 585054004411 putative Mg++ binding site [ion binding]; other site 585054004412 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054004413 nucleotide binding region [chemical binding]; other site 585054004414 ATP-binding site [chemical binding]; other site 585054004415 DEAD/H associated; Region: DEAD_assoc; pfam08494 585054004416 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585054004417 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 585054004418 dimer interface [polypeptide binding]; other site 585054004419 catalytic site [active] 585054004420 putative active site [active] 585054004421 putative substrate binding site [chemical binding]; other site 585054004422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585054004423 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 585054004424 dimer interface [polypeptide binding]; other site 585054004425 active site 585054004426 metal binding site [ion binding]; metal-binding site 585054004427 glutathione binding site [chemical binding]; other site 585054004428 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585054004429 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 585054004430 FMN binding site [chemical binding]; other site 585054004431 active site 585054004432 substrate binding site [chemical binding]; other site 585054004433 catalytic residue [active] 585054004434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585054004435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054004436 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054004437 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054004438 active site 585054004439 catalytic tetrad [active] 585054004440 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585054004441 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585054004442 E-class dimer interface [polypeptide binding]; other site 585054004443 P-class dimer interface [polypeptide binding]; other site 585054004444 active site 585054004445 Cu2+ binding site [ion binding]; other site 585054004446 Zn2+ binding site [ion binding]; other site 585054004447 Fusaric acid resistance protein family; Region: FUSC; pfam04632 585054004448 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585054004449 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585054004450 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054004451 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054004452 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 585054004453 transcriptional regulator SlyA; Provisional; Region: PRK03573 585054004454 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 585054004455 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 585054004456 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 585054004457 lysozyme inhibitor; Provisional; Region: PRK11372 585054004458 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 585054004459 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 585054004460 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 585054004461 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 585054004462 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 585054004463 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 585054004464 active site 585054004465 HIGH motif; other site 585054004466 dimer interface [polypeptide binding]; other site 585054004467 KMSKS motif; other site 585054004468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054004469 RNA binding surface [nucleotide binding]; other site 585054004470 pyridoxamine kinase; Validated; Region: PRK05756 585054004471 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585054004472 dimer interface [polypeptide binding]; other site 585054004473 pyridoxal binding site [chemical binding]; other site 585054004474 ATP binding site [chemical binding]; other site 585054004475 glutathionine S-transferase; Provisional; Region: PRK10542 585054004476 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585054004477 C-terminal domain interface [polypeptide binding]; other site 585054004478 GSH binding site (G-site) [chemical binding]; other site 585054004479 dimer interface [polypeptide binding]; other site 585054004480 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585054004481 dimer interface [polypeptide binding]; other site 585054004482 substrate binding pocket (H-site) [chemical binding]; other site 585054004483 N-terminal domain interface [polypeptide binding]; other site 585054004484 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 585054004485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054004486 putative substrate translocation pore; other site 585054004487 POT family; Region: PTR2; pfam00854 585054004488 endonuclease III; Provisional; Region: PRK10702 585054004489 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585054004490 minor groove reading motif; other site 585054004491 helix-hairpin-helix signature motif; other site 585054004492 substrate binding pocket [chemical binding]; other site 585054004493 active site 585054004494 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 585054004495 electron transport complex RsxE subunit; Provisional; Region: PRK12405 585054004496 electron transport complex protein RnfG; Validated; Region: PRK01908 585054004497 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 585054004498 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 585054004499 SLBB domain; Region: SLBB; pfam10531 585054004500 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585054004501 electron transport complex protein RnfB; Provisional; Region: PRK05113 585054004502 Putative Fe-S cluster; Region: FeS; pfam04060 585054004503 4Fe-4S binding domain; Region: Fer4; pfam00037 585054004504 electron transport complex protein RsxA; Provisional; Region: PRK05151 585054004505 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 585054004506 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 585054004507 putative oxidoreductase; Provisional; Region: PRK11579 585054004508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585054004509 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585054004510 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 585054004511 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 585054004512 active site 585054004513 purine riboside binding site [chemical binding]; other site 585054004514 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585054004515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054004516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054004517 homodimer interface [polypeptide binding]; other site 585054004518 catalytic residue [active] 585054004519 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 585054004520 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 585054004521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585054004522 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 585054004523 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 585054004524 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 585054004525 fumarate hydratase; Provisional; Region: PRK15389 585054004526 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585054004527 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585054004528 fumarate hydratase; Reviewed; Region: fumC; PRK00485 585054004529 Class II fumarases; Region: Fumarase_classII; cd01362 585054004530 active site 585054004531 tetramer interface [polypeptide binding]; other site 585054004532 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 585054004533 sensor protein RstB; Provisional; Region: PRK10604 585054004534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054004535 dimerization interface [polypeptide binding]; other site 585054004536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054004537 dimer interface [polypeptide binding]; other site 585054004538 phosphorylation site [posttranslational modification] 585054004539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054004540 ATP binding site [chemical binding]; other site 585054004541 Mg2+ binding site [ion binding]; other site 585054004542 G-X-G motif; other site 585054004543 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 585054004544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054004545 active site 585054004546 phosphorylation site [posttranslational modification] 585054004547 intermolecular recognition site; other site 585054004548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054004549 DNA binding site [nucleotide binding] 585054004550 GlpM protein; Region: GlpM; pfam06942 585054004551 dihydromonapterin reductase; Provisional; Region: PRK06483 585054004552 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 585054004553 NADP binding site [chemical binding]; other site 585054004554 substrate binding pocket [chemical binding]; other site 585054004555 active site 585054004556 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585054004557 Spore germination protein; Region: Spore_permease; cl17796 585054004558 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585054004559 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585054004560 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585054004561 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 585054004562 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 585054004563 ligand binding site [chemical binding]; other site 585054004564 homodimer interface [polypeptide binding]; other site 585054004565 NAD(P) binding site [chemical binding]; other site 585054004566 trimer interface B [polypeptide binding]; other site 585054004567 trimer interface A [polypeptide binding]; other site 585054004568 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 585054004569 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 585054004570 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 585054004571 CHASE4 domain; Region: CHASE4; pfam05228 585054004572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054004573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054004574 metal binding site [ion binding]; metal-binding site 585054004575 active site 585054004576 I-site; other site 585054004577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054004578 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 585054004579 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585054004580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054004581 putative substrate translocation pore; other site 585054004582 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 585054004583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054004584 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 585054004585 dimerization interface [polypeptide binding]; other site 585054004586 substrate binding pocket [chemical binding]; other site 585054004587 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585054004588 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585054004589 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054004590 nucleotide binding site [chemical binding]; other site 585054004591 putative dithiobiotin synthetase; Provisional; Region: PRK12374 585054004592 AAA domain; Region: AAA_26; pfam13500 585054004593 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585054004594 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585054004595 Cl- selectivity filter; other site 585054004596 Cl- binding residues [ion binding]; other site 585054004597 pore gating glutamate residue; other site 585054004598 dimer interface [polypeptide binding]; other site 585054004599 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 585054004600 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 585054004601 Walker A/P-loop; other site 585054004602 ATP binding site [chemical binding]; other site 585054004603 Q-loop/lid; other site 585054004604 ABC transporter signature motif; other site 585054004605 Walker B; other site 585054004606 D-loop; other site 585054004607 H-loop/switch region; other site 585054004608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 585054004609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004610 dimer interface [polypeptide binding]; other site 585054004611 conserved gate region; other site 585054004612 ABC-ATPase subunit interface; other site 585054004613 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 585054004614 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 585054004615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004616 dimer interface [polypeptide binding]; other site 585054004617 conserved gate region; other site 585054004618 putative PBP binding loops; other site 585054004619 ABC-ATPase subunit interface; other site 585054004620 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 585054004621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585054004622 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 585054004623 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585054004624 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 585054004625 Prostaglandin dehydrogenases; Region: PGDH; cd05288 585054004626 NAD(P) binding site [chemical binding]; other site 585054004627 substrate binding site [chemical binding]; other site 585054004628 dimer interface [polypeptide binding]; other site 585054004629 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 585054004630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054004631 DNA-binding site [nucleotide binding]; DNA binding site 585054004632 FCD domain; Region: FCD; pfam07729 585054004633 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585054004634 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585054004635 N-terminal plug; other site 585054004636 ligand-binding site [chemical binding]; other site 585054004637 PQQ-like domain; Region: PQQ_2; pfam13360 585054004638 L-asparagine permease; Provisional; Region: PRK15049 585054004639 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585054004640 C-terminal domain interface [polypeptide binding]; other site 585054004641 GSH binding site (G-site) [chemical binding]; other site 585054004642 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585054004643 dimer interface [polypeptide binding]; other site 585054004644 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585054004645 dimer interface [polypeptide binding]; other site 585054004646 N-terminal domain interface [polypeptide binding]; other site 585054004647 substrate binding pocket (H-site) [chemical binding]; other site 585054004648 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of transposase (part 1) 585054004649 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of transposase (part 2) 585054004650 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of transposase (partial) 585054004651 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 585054004652 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 585054004653 N-acetyltransferase; Region: Acetyltransf_2; cl00949 585054004654 hypothetical protein; Provisional; Region: PRK10281 585054004655 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 585054004656 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 585054004657 active site pocket [active] 585054004658 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054004659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054004660 DNA binding site [nucleotide binding] 585054004661 domain linker motif; other site 585054004662 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585054004663 putative dimerization interface [polypeptide binding]; other site 585054004664 putative ligand binding site [chemical binding]; other site 585054004665 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 585054004666 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 585054004667 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 585054004668 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 585054004669 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585054004670 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054004671 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 585054004672 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 585054004673 octamer interface [polypeptide binding]; other site 585054004674 active site 585054004675 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 585054004676 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 585054004677 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 585054004678 dimer interface [polypeptide binding]; other site 585054004679 active site 585054004680 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 585054004681 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 585054004682 iron-sulfur cluster [ion binding]; other site 585054004683 [2Fe-2S] cluster binding site [ion binding]; other site 585054004684 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 585054004685 putative alpha subunit interface [polypeptide binding]; other site 585054004686 putative active site [active] 585054004687 putative substrate binding site [chemical binding]; other site 585054004688 Fe binding site [ion binding]; other site 585054004689 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 585054004690 inter-subunit interface; other site 585054004691 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 585054004692 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054004693 catalytic loop [active] 585054004694 iron binding site [ion binding]; other site 585054004695 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 585054004696 FAD binding pocket [chemical binding]; other site 585054004697 FAD binding motif [chemical binding]; other site 585054004698 phosphate binding motif [ion binding]; other site 585054004699 beta-alpha-beta structure motif; other site 585054004700 NAD binding pocket [chemical binding]; other site 585054004701 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 585054004702 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 585054004703 putative NAD(P) binding site [chemical binding]; other site 585054004704 active site 585054004705 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054004706 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585054004707 trimer interface [polypeptide binding]; other site 585054004708 eyelet of channel; other site 585054004709 aromatic amino acid exporter; Provisional; Region: PRK11689 585054004710 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585054004711 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585054004712 [4Fe-4S] binding site [ion binding]; other site 585054004713 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585054004714 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585054004715 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585054004716 molybdopterin cofactor binding site; other site 585054004717 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585054004718 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585054004719 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 585054004720 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585054004721 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of DNA-binding transcriptional regulator (partial) 585054004722 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 585054004723 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 585054004724 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 585054004725 NAD binding site [chemical binding]; other site 585054004726 substrate binding site [chemical binding]; other site 585054004727 catalytic Zn binding site [ion binding]; other site 585054004728 tetramer interface [polypeptide binding]; other site 585054004729 structural Zn binding site [ion binding]; other site 585054004730 malate dehydrogenase; Provisional; Region: PRK13529 585054004731 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585054004732 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 585054004733 NAD(P) binding site [chemical binding]; other site 585054004734 similar to hypothetical protein; Evidence 5 : No homology to any previously reported sequences 585054004735 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 585054004736 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 585054004737 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 585054004738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054004739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054004740 dimerization interface [polypeptide binding]; other site 585054004741 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 585054004742 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 585054004743 heterodimer interface [polypeptide binding]; other site 585054004744 active site 585054004745 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 585054004746 heterodimer interface [polypeptide binding]; other site 585054004747 multimer interface [polypeptide binding]; other site 585054004748 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 585054004749 active site 585054004750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585054004751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585054004752 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 585054004753 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 585054004754 hypothetical protein; Provisional; Region: PRK11415 585054004755 ribosomal-protein-L7/L12-serine acetyltransferase; Provisional; Region: PRK10151 585054004756 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585054004757 Coenzyme A binding pocket [chemical binding]; other site 585054004758 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585054004759 putative trimer interface [polypeptide binding]; other site 585054004760 putative CoA binding site [chemical binding]; other site 585054004761 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585054004762 putative trimer interface [polypeptide binding]; other site 585054004763 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585054004764 putative CoA binding site [chemical binding]; other site 585054004765 putative trimer interface [polypeptide binding]; other site 585054004766 putative CoA binding site [chemical binding]; other site 585054004767 tellurite resistance protein TehB; Provisional; Region: PRK11207 585054004768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054004769 S-adenosylmethionine binding site [chemical binding]; other site 585054004770 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 585054004771 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585054004772 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585054004773 Peptidase family U32; Region: Peptidase_U32; pfam01136 585054004774 Collagenase; Region: DUF3656; pfam12392 585054004775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054004776 DNA binding site [nucleotide binding] 585054004777 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 585054004778 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585054004779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054004780 DNA-binding site [nucleotide binding]; DNA binding site 585054004781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054004782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054004783 homodimer interface [polypeptide binding]; other site 585054004784 catalytic residue [active] 585054004785 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 585054004786 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 585054004787 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 585054004788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054004789 Walker A/P-loop; other site 585054004790 ATP binding site [chemical binding]; other site 585054004791 Q-loop/lid; other site 585054004792 ABC transporter signature motif; other site 585054004793 Walker B; other site 585054004794 D-loop; other site 585054004795 H-loop/switch region; other site 585054004796 TOBE domain; Region: TOBE_2; pfam08402 585054004797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004798 dimer interface [polypeptide binding]; other site 585054004799 conserved gate region; other site 585054004800 putative PBP binding loops; other site 585054004801 ABC-ATPase subunit interface; other site 585054004802 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585054004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054004804 ABC-ATPase subunit interface; other site 585054004805 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 585054004806 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 585054004807 tetrameric interface [polypeptide binding]; other site 585054004808 NAD binding site [chemical binding]; other site 585054004809 catalytic residues [active] 585054004810 substrate binding site [chemical binding]; other site 585054004811 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 585054004812 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 585054004813 lipoprotein; Reviewed; Region: PRK02939 585054004814 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 585054004815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054004816 Coenzyme A binding pocket [chemical binding]; other site 585054004817 hypothetical protein; Provisional; Region: PRK13659 585054004818 hypothetical protein; Provisional; Region: PRK02237 585054004819 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585054004820 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585054004821 putative active site pocket [active] 585054004822 putative metal binding site [ion binding]; other site 585054004823 putative oxidoreductase; Provisional; Region: PRK10083 585054004824 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585054004825 putative NAD(P) binding site [chemical binding]; other site 585054004826 catalytic Zn binding site [ion binding]; other site 585054004827 structural Zn binding site [ion binding]; other site 585054004828 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585054004829 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 585054004830 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585054004831 DctM-like transporters; Region: DctM; pfam06808 585054004832 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 585054004833 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585054004834 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 585054004835 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585054004836 DctM-like transporters; Region: DctM; pfam06808 585054004837 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 585054004838 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585054004839 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054004840 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054004841 YdfZ protein; Region: YdfZ; cl11878 585054004842 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585054004843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054004844 DNA-binding site [nucleotide binding]; DNA binding site 585054004845 FCD domain; Region: FCD; pfam07729 585054004846 malonic semialdehyde reductase; Provisional; Region: PRK10538 585054004847 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 585054004848 putative NAD(P) binding site [chemical binding]; other site 585054004849 homodimer interface [polypeptide binding]; other site 585054004850 homotetramer interface [polypeptide binding]; other site 585054004851 active site 585054004852 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 585054004853 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585054004854 active site 585054004855 Zn binding site [ion binding]; other site 585054004856 Competence-damaged protein; Region: CinA; cl00666 585054004857 hypothetical protein; Provisional; Region: PRK10053 585054004858 diguanylate cyclase; Provisional; Region: PRK09894 585054004859 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 585054004860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054004861 metal binding site [ion binding]; metal-binding site 585054004862 active site 585054004863 I-site; other site 585054004864 putative transporter; Provisional; Region: PRK10054 585054004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054004866 putative substrate translocation pore; other site 585054004867 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 585054004868 EamA-like transporter family; Region: EamA; pfam00892 585054004869 MarB protein; Region: MarB; pfam13999 585054004870 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 585054004871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054004872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054004873 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 585054004874 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585054004875 inner membrane protein; Provisional; Region: PRK10995 585054004876 putative arabinose transporter; Provisional; Region: PRK03545 585054004877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054004878 putative substrate translocation pore; other site 585054004879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054004880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054004881 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 585054004882 putative dimerization interface [polypeptide binding]; other site 585054004883 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 585054004884 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 585054004885 NAD(P) binding site [chemical binding]; other site 585054004886 catalytic residues [active] 585054004887 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585054004888 glutaminase; Provisional; Region: PRK00971 585054004889 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 585054004890 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054004891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054004892 metal binding site [ion binding]; metal-binding site 585054004893 active site 585054004894 I-site; other site 585054004895 altronate oxidoreductase; Provisional; Region: PRK03643 585054004896 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054004897 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054004898 Predicted membrane protein [Function unknown]; Region: COG3781 585054004899 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 585054004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054004901 S-adenosylmethionine binding site [chemical binding]; other site 585054004902 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 585054004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 585054004904 Probable transposase; Region: OrfB_IS605; pfam01385 585054004905 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 585054004906 Transposase IS200 like; Region: Y1_Tnp; pfam01797 585054004907 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 585054004908 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 585054004909 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585054004910 putative active site; other site 585054004911 catalytic residue [active] 585054004912 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 585054004913 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585054004914 ligand binding site [chemical binding]; other site 585054004915 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054004916 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054004917 TM-ABC transporter signature motif; other site 585054004918 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054004919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054004920 TM-ABC transporter signature motif; other site 585054004921 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 585054004922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585054004923 Walker A/P-loop; other site 585054004924 ATP binding site [chemical binding]; other site 585054004925 Q-loop/lid; other site 585054004926 ABC transporter signature motif; other site 585054004927 Walker B; other site 585054004928 D-loop; other site 585054004929 H-loop/switch region; other site 585054004930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054004931 transcriptional regulator LsrR; Provisional; Region: PRK15418 585054004932 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585054004933 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585054004934 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 585054004935 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 585054004936 putative N- and C-terminal domain interface [polypeptide binding]; other site 585054004937 putative active site [active] 585054004938 putative MgATP binding site [chemical binding]; other site 585054004939 catalytic site [active] 585054004940 metal binding site [ion binding]; metal-binding site 585054004941 putative carbohydrate binding site [chemical binding]; other site 585054004942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585054004943 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585054004944 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 585054004945 putative C-terminal domain interface [polypeptide binding]; other site 585054004946 putative GSH binding site (G-site) [chemical binding]; other site 585054004947 putative dimer interface [polypeptide binding]; other site 585054004948 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 585054004949 dimer interface [polypeptide binding]; other site 585054004950 N-terminal domain interface [polypeptide binding]; other site 585054004951 substrate binding pocket (H-site) [chemical binding]; other site 585054004952 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585054004953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054004954 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585054004955 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 585054004956 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 585054004957 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 585054004958 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585054004959 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585054004960 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585054004961 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585054004962 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585054004963 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585054004964 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585054004965 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585054004966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054004967 catalytic residue [active] 585054004968 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 585054004969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 585054004970 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 585054004971 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 585054004972 heme-binding site [chemical binding]; other site 585054004973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054004974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054004975 metal binding site [ion binding]; metal-binding site 585054004976 active site 585054004977 I-site; other site 585054004978 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 585054004979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054004980 putative active site [active] 585054004981 heme pocket [chemical binding]; other site 585054004982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054004983 putative active site [active] 585054004984 heme pocket [chemical binding]; other site 585054004985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054004986 metal binding site [ion binding]; metal-binding site 585054004987 active site 585054004988 I-site; other site 585054004989 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054004990 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 585054004991 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 585054004992 substrate binding site [chemical binding]; other site 585054004993 catalytic Zn binding site [ion binding]; other site 585054004994 NAD binding site [chemical binding]; other site 585054004995 structural Zn binding site [ion binding]; other site 585054004996 dimer interface [polypeptide binding]; other site 585054004997 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585054004998 putative metal binding site [ion binding]; other site 585054004999 putative homodimer interface [polypeptide binding]; other site 585054005000 putative homotetramer interface [polypeptide binding]; other site 585054005001 putative homodimer-homodimer interface [polypeptide binding]; other site 585054005002 putative allosteric switch controlling residues; other site 585054005003 cytochrome b561; Provisional; Region: PRK11513 585054005004 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 585054005005 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585054005006 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585054005007 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585054005008 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585054005009 putative active site [active] 585054005010 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 585054005011 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 585054005012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054005013 ATP binding site [chemical binding]; other site 585054005014 putative Mg++ binding site [ion binding]; other site 585054005015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054005016 nucleotide binding region [chemical binding]; other site 585054005017 ATP-binding site [chemical binding]; other site 585054005018 Helicase associated domain (HA2); Region: HA2; pfam04408 585054005019 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 585054005020 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 585054005021 azoreductase; Reviewed; Region: PRK00170 585054005022 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585054005023 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 585054005024 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585054005025 active site 585054005026 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 585054005027 active site 585054005028 catalytic residues [active] 585054005029 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 585054005030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585054005031 Putative methyltransferase; Region: Methyltransf_20; pfam12147 585054005032 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 585054005033 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585054005034 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585054005035 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 585054005036 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 585054005037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054005038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054005039 active site 585054005040 catalytic tetrad [active] 585054005041 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 585054005042 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585054005043 putative trimer interface [polypeptide binding]; other site 585054005044 putative metal binding site [ion binding]; other site 585054005045 PaaX-like protein; Region: PaaX; pfam07848 585054005046 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 585054005047 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 585054005048 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 585054005049 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 585054005050 active site 585054005051 AMP binding site [chemical binding]; other site 585054005052 homodimer interface [polypeptide binding]; other site 585054005053 acyl-activating enzyme (AAE) consensus motif; other site 585054005054 CoA binding site [chemical binding]; other site 585054005055 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 585054005056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585054005057 dimer interface [polypeptide binding]; other site 585054005058 active site 585054005059 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585054005060 CoenzymeA binding site [chemical binding]; other site 585054005061 subunit interaction site [polypeptide binding]; other site 585054005062 PHB binding site; other site 585054005063 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 585054005064 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585054005065 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585054005066 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585054005067 enoyl-CoA hydratase; Provisional; Region: PRK08140 585054005068 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054005069 substrate binding site [chemical binding]; other site 585054005070 oxyanion hole (OAH) forming residues; other site 585054005071 trimer interface [polypeptide binding]; other site 585054005072 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 585054005073 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054005074 substrate binding site [chemical binding]; other site 585054005075 oxyanion hole (OAH) forming residues; other site 585054005076 trimer interface [polypeptide binding]; other site 585054005077 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 585054005078 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 585054005079 FAD binding pocket [chemical binding]; other site 585054005080 FAD binding motif [chemical binding]; other site 585054005081 phosphate binding motif [ion binding]; other site 585054005082 beta-alpha-beta structure motif; other site 585054005083 NAD(p) ribose binding residues [chemical binding]; other site 585054005084 NAD binding pocket [chemical binding]; other site 585054005085 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 585054005086 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054005087 catalytic loop [active] 585054005088 iron binding site [ion binding]; other site 585054005089 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 585054005090 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 585054005091 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 585054005092 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 585054005093 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 585054005094 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 585054005095 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 585054005096 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 585054005097 substrate binding site [chemical binding]; other site 585054005098 dimer interface [polypeptide binding]; other site 585054005099 NADP binding site [chemical binding]; other site 585054005100 catalytic residues [active] 585054005101 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 585054005102 substrate binding site [chemical binding]; other site 585054005103 tyramine oxidase; Provisional; Region: tynA; PRK14696 585054005104 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 585054005105 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 585054005106 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 585054005107 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 585054005108 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 585054005109 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585054005110 NAD(P) binding site [chemical binding]; other site 585054005111 catalytic residues [active] 585054005112 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 585054005113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054005114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 585054005115 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 585054005116 hypothetical protein; Provisional; Region: PRK10695 585054005117 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 585054005118 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 585054005119 putative ligand binding site [chemical binding]; other site 585054005120 putative NAD binding site [chemical binding]; other site 585054005121 catalytic site [active] 585054005122 heat-inducible protein; Provisional; Region: PRK10449 585054005123 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585054005124 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585054005125 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 585054005126 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 585054005127 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 585054005128 dimer interface [polypeptide binding]; other site 585054005129 PYR/PP interface [polypeptide binding]; other site 585054005130 TPP binding site [chemical binding]; other site 585054005131 substrate binding site [chemical binding]; other site 585054005132 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 585054005133 Domain of unknown function; Region: EKR; smart00890 585054005134 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585054005135 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 585054005136 TPP-binding site [chemical binding]; other site 585054005137 dimer interface [polypeptide binding]; other site 585054005138 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054005139 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585054005140 trimer interface [polypeptide binding]; other site 585054005141 eyelet of channel; other site 585054005142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054005143 Ligand Binding Site [chemical binding]; other site 585054005144 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 585054005145 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 585054005146 Ligand Binding Site [chemical binding]; other site 585054005147 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 585054005148 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585054005149 ATP binding site [chemical binding]; other site 585054005150 Mg++ binding site [ion binding]; other site 585054005151 motif III; other site 585054005152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054005153 nucleotide binding region [chemical binding]; other site 585054005154 ATP-binding site [chemical binding]; other site 585054005155 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 585054005156 putative RNA binding site [nucleotide binding]; other site 585054005157 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585054005158 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 585054005159 Cl binding site [ion binding]; other site 585054005160 oligomer interface [polypeptide binding]; other site 585054005161 PAS domain S-box; Region: sensory_box; TIGR00229 585054005162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054005163 putative active site [active] 585054005164 heme pocket [chemical binding]; other site 585054005165 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054005166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054005167 metal binding site [ion binding]; metal-binding site 585054005168 active site 585054005169 I-site; other site 585054005170 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 585054005171 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 585054005172 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 585054005173 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 585054005174 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 585054005175 tetramer interface [polypeptide binding]; other site 585054005176 active site 585054005177 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 585054005178 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585054005179 dimer interface [polypeptide binding]; other site 585054005180 active site 585054005181 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 585054005182 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 585054005183 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 585054005184 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585054005185 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054005186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 585054005187 Smr domain; Region: Smr; pfam01713 585054005188 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 585054005189 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585054005190 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585054005191 DNA binding site [nucleotide binding] 585054005192 active site 585054005193 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 585054005194 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585054005195 ligand binding site [chemical binding]; other site 585054005196 flexible hinge region; other site 585054005197 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585054005198 putative switch regulator; other site 585054005199 non-specific DNA interactions [nucleotide binding]; other site 585054005200 DNA binding site [nucleotide binding] 585054005201 sequence specific DNA binding site [nucleotide binding]; other site 585054005202 putative cAMP binding site [chemical binding]; other site 585054005203 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 585054005204 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 585054005205 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585054005206 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585054005207 catalytic residues [active] 585054005208 catalytic nucleophile [active] 585054005209 Presynaptic Site I dimer interface [polypeptide binding]; other site 585054005210 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585054005211 Synaptic Flat tetramer interface [polypeptide binding]; other site 585054005212 Synaptic Site I dimer interface [polypeptide binding]; other site 585054005213 DNA binding site [nucleotide binding] 585054005214 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 585054005215 beta-lactamase TEM; Provisional; Region: PRK15442 585054005216 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 585054005217 universal stress protein UspE; Provisional; Region: PRK11175 585054005218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054005219 Ligand Binding Site [chemical binding]; other site 585054005220 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054005221 Ligand Binding Site [chemical binding]; other site 585054005222 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 585054005223 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585054005224 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585054005225 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585054005226 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585054005227 peptide binding site [polypeptide binding]; other site 585054005228 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 585054005229 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 585054005230 putative active site [active] 585054005231 Zn binding site [ion binding]; other site 585054005232 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 585054005233 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 585054005234 active site 585054005235 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 585054005236 dimer interface [polypeptide binding]; other site 585054005237 catalytic triad [active] 585054005238 peroxidatic and resolving cysteines [active] 585054005239 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 585054005240 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 585054005241 putative aromatic amino acid binding site; other site 585054005242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054005243 Walker A motif; other site 585054005244 ATP binding site [chemical binding]; other site 585054005245 Walker B motif; other site 585054005246 arginine finger; other site 585054005247 hypothetical protein; Provisional; Region: PRK05415 585054005248 TIGR01620 family protein; Region: hyp_HI0043 585054005249 Predicted ATPase [General function prediction only]; Region: COG3106 585054005250 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585054005251 active site residue [active] 585054005252 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 585054005253 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 585054005254 phage shock protein C; Region: phageshock_pspC; TIGR02978 585054005255 phage shock protein B; Provisional; Region: pspB; PRK09458 585054005256 phage shock protein PspA; Provisional; Region: PRK10698 585054005257 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 585054005258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054005259 Walker A motif; other site 585054005260 ATP binding site [chemical binding]; other site 585054005261 Walker B motif; other site 585054005262 arginine finger; other site 585054005263 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054005264 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585054005265 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585054005266 peptide binding site [polypeptide binding]; other site 585054005267 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 585054005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054005269 dimer interface [polypeptide binding]; other site 585054005270 conserved gate region; other site 585054005271 putative PBP binding loops; other site 585054005272 ABC-ATPase subunit interface; other site 585054005273 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 585054005274 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585054005275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054005276 dimer interface [polypeptide binding]; other site 585054005277 conserved gate region; other site 585054005278 putative PBP binding loops; other site 585054005279 ABC-ATPase subunit interface; other site 585054005280 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 585054005281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054005282 Walker A/P-loop; other site 585054005283 ATP binding site [chemical binding]; other site 585054005284 Q-loop/lid; other site 585054005285 ABC transporter signature motif; other site 585054005286 Walker B; other site 585054005287 D-loop; other site 585054005288 H-loop/switch region; other site 585054005289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585054005290 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 585054005291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054005292 Walker A/P-loop; other site 585054005293 ATP binding site [chemical binding]; other site 585054005294 Q-loop/lid; other site 585054005295 ABC transporter signature motif; other site 585054005296 Walker B; other site 585054005297 D-loop; other site 585054005298 H-loop/switch region; other site 585054005299 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 585054005300 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 585054005301 NAD binding site [chemical binding]; other site 585054005302 homotetramer interface [polypeptide binding]; other site 585054005303 homodimer interface [polypeptide binding]; other site 585054005304 substrate binding site [chemical binding]; other site 585054005305 active site 585054005306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 585054005307 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 585054005308 exoribonuclease II; Provisional; Region: PRK05054 585054005309 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585054005310 RNB domain; Region: RNB; pfam00773 585054005311 S1 RNA binding domain; Region: S1; pfam00575 585054005312 RNase II stability modulator; Provisional; Region: PRK10060 585054005313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054005314 putative active site [active] 585054005315 heme pocket [chemical binding]; other site 585054005316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054005317 metal binding site [ion binding]; metal-binding site 585054005318 active site 585054005319 I-site; other site 585054005320 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054005321 hypothetical protein; Provisional; Region: PRK13658 585054005322 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585054005323 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585054005324 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585054005325 lipoprotein; Provisional; Region: PRK10540 585054005326 translation initiation factor Sui1; Validated; Region: PRK06824 585054005327 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 585054005328 putative rRNA binding site [nucleotide binding]; other site 585054005329 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 585054005330 active site 585054005331 dimer interface [polypeptide binding]; other site 585054005332 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 585054005333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585054005334 TPR motif; other site 585054005335 binding surface 585054005336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585054005337 binding surface 585054005338 TPR motif; other site 585054005339 Predicted membrane protein [Function unknown]; Region: COG3771 585054005340 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585054005341 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585054005342 active site 585054005343 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 585054005344 dimerization interface [polypeptide binding]; other site 585054005345 active site 585054005346 aconitate hydratase; Validated; Region: PRK09277 585054005347 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 585054005348 substrate binding site [chemical binding]; other site 585054005349 ligand binding site [chemical binding]; other site 585054005350 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 585054005351 substrate binding site [chemical binding]; other site 585054005352 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 585054005353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054005354 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 585054005355 substrate binding site [chemical binding]; other site 585054005356 putative dimerization interface [polypeptide binding]; other site 585054005357 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 585054005358 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 585054005359 active site 585054005360 interdomain interaction site; other site 585054005361 putative metal-binding site [ion binding]; other site 585054005362 nucleotide binding site [chemical binding]; other site 585054005363 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585054005364 domain I; other site 585054005365 DNA binding groove [nucleotide binding] 585054005366 phosphate binding site [ion binding]; other site 585054005367 domain II; other site 585054005368 domain III; other site 585054005369 nucleotide binding site [chemical binding]; other site 585054005370 catalytic site [active] 585054005371 domain IV; other site 585054005372 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585054005373 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585054005374 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585054005375 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585054005376 hypothetical protein; Provisional; Region: PRK11037 585054005377 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 585054005378 putative inner membrane peptidase; Provisional; Region: PRK11778 585054005379 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 585054005380 tandem repeat interface [polypeptide binding]; other site 585054005381 oligomer interface [polypeptide binding]; other site 585054005382 active site residues [active] 585054005383 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 585054005384 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 585054005385 NADP binding site [chemical binding]; other site 585054005386 homodimer interface [polypeptide binding]; other site 585054005387 active site 585054005388 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 585054005389 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 585054005390 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 585054005391 homodimer interface [polypeptide binding]; other site 585054005392 Walker A motif; other site 585054005393 ATP binding site [chemical binding]; other site 585054005394 hydroxycobalamin binding site [chemical binding]; other site 585054005395 Walker B motif; other site 585054005396 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 585054005397 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054005398 RNA binding surface [nucleotide binding]; other site 585054005399 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 585054005400 probable active site [active] 585054005401 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 585054005402 hypothetical protein; Provisional; Region: PRK11630 585054005403 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 585054005404 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585054005405 active site 585054005406 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585054005407 anthranilate synthase component I; Provisional; Region: PRK13564 585054005408 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585054005409 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585054005410 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 585054005411 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585054005412 glutamine binding [chemical binding]; other site 585054005413 catalytic triad [active] 585054005414 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585054005415 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585054005416 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 585054005417 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 585054005418 active site 585054005419 ribulose/triose binding site [chemical binding]; other site 585054005420 phosphate binding site [ion binding]; other site 585054005421 substrate (anthranilate) binding pocket [chemical binding]; other site 585054005422 product (indole) binding pocket [chemical binding]; other site 585054005423 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 585054005424 active site 585054005425 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 585054005426 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 585054005427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054005428 catalytic residue [active] 585054005429 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 585054005430 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 585054005431 substrate binding site [chemical binding]; other site 585054005432 active site 585054005433 catalytic residues [active] 585054005434 heterodimer interface [polypeptide binding]; other site 585054005435 outer membrane protein W; Provisional; Region: PRK10959 585054005436 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 585054005437 hypothetical protein; Provisional; Region: PRK02868 585054005438 intracellular septation protein A; Reviewed; Region: PRK00259 585054005439 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 585054005440 transport protein TonB; Provisional; Region: PRK10819 585054005441 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585054005442 YciI-like protein; Reviewed; Region: PRK11370 585054005443 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054005444 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 585054005445 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 585054005446 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 585054005447 putative active site [active] 585054005448 catalytic site [active] 585054005449 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 585054005450 putative active site [active] 585054005451 catalytic site [active] 585054005452 dsDNA-mimic protein; Reviewed; Region: PRK05094 585054005453 Ion transport protein; Region: Ion_trans; pfam00520 585054005454 Ion channel; Region: Ion_trans_2; pfam07885 585054005455 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 585054005456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054005457 Walker A/P-loop; other site 585054005458 ATP binding site [chemical binding]; other site 585054005459 Q-loop/lid; other site 585054005460 ABC transporter signature motif; other site 585054005461 Walker B; other site 585054005462 D-loop; other site 585054005463 H-loop/switch region; other site 585054005464 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585054005465 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 585054005466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054005467 Walker A/P-loop; other site 585054005468 ATP binding site [chemical binding]; other site 585054005469 Q-loop/lid; other site 585054005470 ABC transporter signature motif; other site 585054005471 Walker B; other site 585054005472 D-loop; other site 585054005473 H-loop/switch region; other site 585054005474 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585054005475 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 585054005476 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585054005477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054005478 dimer interface [polypeptide binding]; other site 585054005479 conserved gate region; other site 585054005480 ABC-ATPase subunit interface; other site 585054005481 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 585054005482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054005483 dimer interface [polypeptide binding]; other site 585054005484 conserved gate region; other site 585054005485 putative PBP binding loops; other site 585054005486 ABC-ATPase subunit interface; other site 585054005487 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585054005488 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585054005489 peptide binding site [polypeptide binding]; other site 585054005490 hypothetical protein; Provisional; Region: PRK11111 585054005491 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 585054005492 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 585054005493 putative catalytic cysteine [active] 585054005494 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 585054005495 putative active site [active] 585054005496 metal binding site [ion binding]; metal-binding site 585054005497 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of IS4 transposase; KpLE2 phage-like element (partial) 585054005498 Evidence 7 : Gene remnant; PubMedId : 6268937; Product type pe : enzyme; transposase (fragment), IS4 585054005499 thymidine kinase; Provisional; Region: PRK04296 585054005500 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 585054005501 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585054005502 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585054005503 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 585054005504 active site 585054005505 tetramer interface; other site 585054005506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054005507 active site 585054005508 response regulator of RpoS; Provisional; Region: PRK10693 585054005509 phosphorylation site [posttranslational modification] 585054005510 intermolecular recognition site; other site 585054005511 dimerization interface [polypeptide binding]; other site 585054005512 hypothetical protein; Provisional; Region: PRK10279 585054005513 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 585054005514 active site 585054005515 nucleophile elbow; other site 585054005516 SEC-C motif; Region: SEC-C; pfam02810 585054005517 hypothetical protein; Provisional; Region: PRK04233 585054005518 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 585054005519 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 585054005520 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 585054005521 putative active site [active] 585054005522 putative substrate binding site [chemical binding]; other site 585054005523 putative cosubstrate binding site; other site 585054005524 catalytic site [active] 585054005525 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 585054005526 putative di-iron ligands [ion binding]; other site 585054005527 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 585054005528 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 585054005529 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 585054005530 active site 585054005531 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 585054005532 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 585054005533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585054005534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585054005535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054005536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054005537 NAD(P) binding site [chemical binding]; other site 585054005538 active site 585054005539 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 585054005540 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 585054005541 dimer interface [polypeptide binding]; other site 585054005542 active site 585054005543 CoA binding pocket [chemical binding]; other site 585054005544 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585054005545 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 585054005546 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585054005547 4Fe-4S binding domain; Region: Fer4; cl02805 585054005548 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 585054005549 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585054005550 [4Fe-4S] binding site [ion binding]; other site 585054005551 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585054005552 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585054005553 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585054005554 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585054005555 molybdopterin cofactor binding site; other site 585054005556 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585054005557 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 585054005558 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585054005559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054005560 dimerization interface [polypeptide binding]; other site 585054005561 Histidine kinase; Region: HisKA_3; pfam07730 585054005562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054005563 ATP binding site [chemical binding]; other site 585054005564 Mg2+ binding site [ion binding]; other site 585054005565 G-X-G motif; other site 585054005566 transcriptional regulator NarL; Provisional; Region: PRK10651 585054005567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054005568 active site 585054005569 phosphorylation site [posttranslational modification] 585054005570 intermolecular recognition site; other site 585054005571 dimerization interface [polypeptide binding]; other site 585054005572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054005573 DNA binding residues [nucleotide binding] 585054005574 dimerization interface [polypeptide binding]; other site 585054005575 putative invasin; Provisional; Region: PRK10177 585054005576 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585054005577 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 585054005578 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 585054005579 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585054005580 putative active site pocket [active] 585054005581 dimerization interface [polypeptide binding]; other site 585054005582 putative catalytic residue [active] 585054005583 cation transport regulator; Reviewed; Region: chaB; PRK09582 585054005584 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 585054005585 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585054005586 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 585054005587 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585054005588 hypothetical protein; Provisional; Region: PRK10941 585054005589 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 585054005590 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 585054005591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054005592 peptide chain release factor 1; Validated; Region: prfA; PRK00591 585054005593 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585054005594 RF-1 domain; Region: RF-1; pfam00472 585054005595 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 585054005596 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 585054005597 tRNA; other site 585054005598 putative tRNA binding site [nucleotide binding]; other site 585054005599 putative NADP binding site [chemical binding]; other site 585054005600 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 585054005601 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 585054005602 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 585054005603 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 585054005604 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585054005605 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 585054005606 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 585054005607 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 585054005608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054005609 active site 585054005610 putative transporter; Provisional; Region: PRK11660 585054005611 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 585054005612 Sulfate transporter family; Region: Sulfate_transp; pfam00916 585054005613 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 585054005614 hypothetical protein; Provisional; Region: PRK10692 585054005615 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 585054005616 putative active site [active] 585054005617 catalytic residue [active] 585054005618 GTP-binding protein YchF; Reviewed; Region: PRK09601 585054005619 YchF GTPase; Region: YchF; cd01900 585054005620 G1 box; other site 585054005621 GTP/Mg2+ binding site [chemical binding]; other site 585054005622 Switch I region; other site 585054005623 G2 box; other site 585054005624 Switch II region; other site 585054005625 G3 box; other site 585054005626 G4 box; other site 585054005627 G5 box; other site 585054005628 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 585054005629 trehalase; Provisional; Region: treA; PRK13271 585054005630 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 585054005631 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 585054005632 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 585054005633 Flagellar regulator YcgR; Region: YcgR; pfam07317 585054005634 PilZ domain; Region: PilZ; pfam07238 585054005635 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 585054005636 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054005637 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054005638 catalytic residue [active] 585054005639 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 585054005640 dimer interface [polypeptide binding]; other site 585054005641 catalytic triad [active] 585054005642 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 585054005643 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585054005644 TrkA-C domain; Region: TrkA_C; pfam02080 585054005645 Transporter associated domain; Region: CorC_HlyC; smart01091 585054005646 alanine racemase; Reviewed; Region: dadX; PRK03646 585054005647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585054005648 active site 585054005649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054005650 substrate binding site [chemical binding]; other site 585054005651 catalytic residues [active] 585054005652 dimer interface [polypeptide binding]; other site 585054005653 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 585054005654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585054005655 SpoVR family protein; Provisional; Region: PRK11767 585054005656 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 585054005657 fatty acid metabolism regulator; Provisional; Region: PRK04984 585054005658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054005659 DNA-binding site [nucleotide binding]; DNA binding site 585054005660 FadR C-terminal domain; Region: FadR_C; pfam07840 585054005661 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 585054005662 disulfide bond formation protein B; Provisional; Region: PRK01749 585054005663 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585054005664 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585054005665 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585054005666 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585054005667 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 585054005668 hypothetical protein; Provisional; Region: PRK05170 585054005669 hypothetical protein; Provisional; Region: PRK10691 585054005670 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 585054005671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 585054005672 septum formation inhibitor; Reviewed; Region: minC; PRK03511 585054005673 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 585054005674 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 585054005675 cell division inhibitor MinD; Provisional; Region: PRK10818 585054005676 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 585054005677 Switch I; other site 585054005678 Switch II; other site 585054005679 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 585054005680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054005681 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 585054005682 Walker A/P-loop; other site 585054005683 ATP binding site [chemical binding]; other site 585054005684 Q-loop/lid; other site 585054005685 ABC transporter signature motif; other site 585054005686 Walker B; other site 585054005687 D-loop; other site 585054005688 H-loop/switch region; other site 585054005689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054005690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 585054005691 Walker A/P-loop; other site 585054005692 ATP binding site [chemical binding]; other site 585054005693 Q-loop/lid; other site 585054005694 ABC transporter signature motif; other site 585054005695 Walker B; other site 585054005696 D-loop; other site 585054005697 H-loop/switch region; other site 585054005698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 585054005699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054005700 dimer interface [polypeptide binding]; other site 585054005701 conserved gate region; other site 585054005702 putative PBP binding loops; other site 585054005703 ABC-ATPase subunit interface; other site 585054005704 nickel transporter permease NikB; Provisional; Region: PRK10352 585054005705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054005706 dimer interface [polypeptide binding]; other site 585054005707 conserved gate region; other site 585054005708 putative PBP binding loops; other site 585054005709 ABC-ATPase subunit interface; other site 585054005710 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 585054005711 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 585054005712 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585054005713 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585054005714 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 585054005715 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 585054005716 metal binding site [ion binding]; metal-binding site 585054005717 putative dimer interface [polypeptide binding]; other site 585054005718 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 585054005719 hypothetical protein; Provisional; Region: PRK12378 585054005720 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585054005721 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585054005722 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 585054005723 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 585054005724 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 585054005725 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585054005726 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 585054005727 dimer interface [polypeptide binding]; other site 585054005728 N-terminal domain interface [polypeptide binding]; other site 585054005729 substrate binding pocket (H-site) [chemical binding]; other site 585054005730 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 585054005731 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of phage integrase (partial) 585054005732 isocitrate dehydrogenase; Validated; Region: PRK07362 585054005733 isocitrate dehydrogenase; Reviewed; Region: PRK07006 585054005734 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 585054005735 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 585054005736 probable active site [active] 585054005737 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 585054005738 nudix motif; other site 585054005739 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 585054005740 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 585054005741 putative lysogenization regulator; Reviewed; Region: PRK00218 585054005742 adenylosuccinate lyase; Provisional; Region: PRK09285 585054005743 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 585054005744 tetramer interface [polypeptide binding]; other site 585054005745 active site 585054005746 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 585054005747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054005748 active site 585054005749 phosphorylation site [posttranslational modification] 585054005750 intermolecular recognition site; other site 585054005751 dimerization interface [polypeptide binding]; other site 585054005752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054005753 DNA binding site [nucleotide binding] 585054005754 sensor protein PhoQ; Provisional; Region: PRK10815 585054005755 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 585054005756 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 585054005757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054005758 ATP binding site [chemical binding]; other site 585054005759 Mg2+ binding site [ion binding]; other site 585054005760 G-X-G motif; other site 585054005761 Uncharacterized conserved protein [Function unknown]; Region: COG2850 585054005762 Cupin-like domain; Region: Cupin_8; pfam13621 585054005763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054005764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054005765 active site 585054005766 catalytic tetrad [active] 585054005767 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585054005768 PrkA family serine protein kinase; Provisional; Region: PRK15455 585054005769 AAA ATPase domain; Region: AAA_16; pfam13191 585054005770 Walker A motif; other site 585054005771 ATP binding site [chemical binding]; other site 585054005772 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 585054005773 hypothetical protein; Provisional; Region: PRK05325 585054005774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054005775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054005776 metal binding site [ion binding]; metal-binding site 585054005777 active site 585054005778 I-site; other site 585054005779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054005780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054005781 metal binding site [ion binding]; metal-binding site 585054005782 active site 585054005783 I-site; other site 585054005784 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 585054005785 putative deacylase active site [active] 585054005786 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054005787 Predicted membrane protein [Function unknown]; Region: COG2707 585054005788 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 585054005789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054005790 Uncharacterized conserved protein [Function unknown]; Region: COG3189 585054005791 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585054005792 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585054005793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 585054005794 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585054005795 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054005796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054005797 metal binding site [ion binding]; metal-binding site 585054005798 active site 585054005799 I-site; other site 585054005800 hypothetical protein; Provisional; Region: PRK10457 585054005801 leucine export protein LeuE; Provisional; Region: PRK10958 585054005802 hypothetical protein; Provisional; Region: PRK11280 585054005803 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 585054005804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054005805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054005806 hypothetical protein; Provisional; Region: PRK04940 585054005807 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 585054005808 beta-hexosaminidase; Provisional; Region: PRK05337 585054005809 thiamine kinase; Region: ycfN_thiK; TIGR02721 585054005810 thiamine kinase; Provisional; Region: thiK; PRK10271 585054005811 substrate binding site [chemical binding]; other site 585054005812 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 585054005813 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 585054005814 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 585054005815 putative dimer interface [polypeptide binding]; other site 585054005816 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 585054005817 nucleotide binding site/active site [active] 585054005818 HIT family signature motif; other site 585054005819 catalytic residue [active] 585054005820 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 585054005821 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585054005822 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054005823 active site turn [active] 585054005824 phosphorylation site [posttranslational modification] 585054005825 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585054005826 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585054005827 active site 585054005828 DNA polymerase III subunit delta'; Validated; Region: PRK07993 585054005829 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 585054005830 thymidylate kinase; Validated; Region: tmk; PRK00698 585054005831 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585054005832 TMP-binding site; other site 585054005833 ATP-binding site [chemical binding]; other site 585054005834 conserved hypothetical protein, YceG family; Region: TIGR00247 585054005835 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 585054005836 dimerization interface [polypeptide binding]; other site 585054005837 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585054005838 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 585054005839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054005840 catalytic residue [active] 585054005841 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 585054005842 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585054005843 dimer interface [polypeptide binding]; other site 585054005844 active site 585054005845 acyl carrier protein; Provisional; Region: acpP; PRK00982 585054005846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 585054005847 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 585054005848 NAD(P) binding site [chemical binding]; other site 585054005849 homotetramer interface [polypeptide binding]; other site 585054005850 homodimer interface [polypeptide binding]; other site 585054005851 active site 585054005852 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 585054005853 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585054005854 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 585054005855 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 585054005856 dimer interface [polypeptide binding]; other site 585054005857 active site 585054005858 CoA binding pocket [chemical binding]; other site 585054005859 putative phosphate acyltransferase; Provisional; Region: PRK05331 585054005860 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 585054005861 hypothetical protein; Provisional; Region: PRK11193 585054005862 Maf-like protein; Region: Maf; pfam02545 585054005863 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585054005864 active site 585054005865 dimer interface [polypeptide binding]; other site 585054005866 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 585054005867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054005868 RNA binding surface [nucleotide binding]; other site 585054005869 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585054005870 active site 585054005871 ribonuclease E; Reviewed; Region: rne; PRK10811 585054005872 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585054005873 homodimer interface [polypeptide binding]; other site 585054005874 oligonucleotide binding site [chemical binding]; other site 585054005875 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 585054005876 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 585054005877 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585054005878 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 585054005879 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585054005880 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585054005881 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 585054005882 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 585054005883 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 585054005884 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 585054005885 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 585054005886 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 585054005887 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 585054005888 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 585054005889 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585054005890 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585054005891 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 585054005892 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585054005893 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 585054005894 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 585054005895 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585054005896 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 585054005897 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585054005898 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 585054005899 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 585054005900 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 585054005901 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 585054005902 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585054005903 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585054005904 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 585054005905 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 585054005906 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 585054005907 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 585054005908 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 585054005909 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 585054005910 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 585054005911 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 585054005912 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 585054005913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585054005914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585054005915 hypothetical protein; Provisional; Region: PRK11239 585054005916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 585054005917 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 585054005918 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585054005919 multidrug resistance protein MdtH; Provisional; Region: PRK11646 585054005920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054005921 putative substrate translocation pore; other site 585054005922 lipoprotein; Provisional; Region: PRK10598 585054005923 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 585054005924 active site 585054005925 substrate binding pocket [chemical binding]; other site 585054005926 dimer interface [polypeptide binding]; other site 585054005927 DNA damage-inducible protein I; Provisional; Region: PRK10597 585054005928 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 585054005929 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 585054005930 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585054005931 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585054005932 hypothetical protein; Provisional; Region: PRK03757 585054005933 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 585054005934 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 585054005935 active site residue [active] 585054005936 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585054005937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585054005938 putative acyl-acceptor binding pocket; other site 585054005939 drug efflux system protein MdtG; Provisional; Region: PRK09874 585054005940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054005941 putative substrate translocation pore; other site 585054005942 secY/secA suppressor protein; Provisional; Region: PRK11467 585054005943 lipoprotein; Provisional; Region: PRK10175 585054005944 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 585054005945 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 585054005946 Ligand binding site; other site 585054005947 DXD motif; other site 585054005948 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 585054005949 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 585054005950 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 585054005951 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585054005952 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 585054005953 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 585054005954 putative active site [active] 585054005955 catalytic site [active] 585054005956 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 585054005957 putative active site [active] 585054005958 catalytic site [active] 585054005959 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 585054005960 putative ADP-ribose binding site [chemical binding]; other site 585054005961 putative active site [active] 585054005962 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585054005963 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 585054005964 major curlin subunit; Provisional; Region: csgA; PRK10051 585054005965 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 585054005966 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585054005967 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585054005968 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 585054005969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054005970 DNA binding residues [nucleotide binding] 585054005971 dimerization interface [polypeptide binding]; other site 585054005972 curli assembly protein CsgE; Provisional; Region: PRK10386 585054005973 curli assembly protein CsgF; Provisional; Region: PRK10050 585054005974 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 585054005975 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585054005976 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 585054005977 putative hydrolase; Validated; Region: PRK09248 585054005978 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 585054005979 active site 585054005980 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 585054005981 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 585054005982 putative ligand binding site [chemical binding]; other site 585054005983 NAD binding site [chemical binding]; other site 585054005984 dimerization interface [polypeptide binding]; other site 585054005985 catalytic site [active] 585054005986 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 585054005987 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585054005988 dimer interface [polypeptide binding]; other site 585054005989 putative anticodon binding site; other site 585054005990 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585054005991 motif 1; other site 585054005992 active site 585054005993 motif 2; other site 585054005994 motif 3; other site 585054005995 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585054005996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054005997 putative substrate translocation pore; other site 585054005998 POT family; Region: PTR2; pfam00854 585054005999 lysine decarboxylase CadA; Provisional; Region: PRK15400 585054006000 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585054006001 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585054006002 homodimer interface [polypeptide binding]; other site 585054006003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054006004 catalytic residue [active] 585054006005 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585054006006 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 585054006007 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 585054006008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054006009 DNA binding site [nucleotide binding] 585054006010 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054006011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054006012 metal binding site [ion binding]; metal-binding site 585054006013 active site 585054006014 I-site; other site 585054006015 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 585054006016 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 585054006017 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 585054006018 putative active site [active] 585054006019 putative metal binding site [ion binding]; other site 585054006020 N-glycosyltransferase; Provisional; Region: PRK11204 585054006021 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585054006022 DXD motif; other site 585054006023 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585054006024 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 585054006025 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585054006026 hypothetical protein; Provisional; Region: PRK10536 585054006027 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 585054006028 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 585054006029 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 585054006030 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 585054006031 Imelysin; Region: Peptidase_M75; pfam09375 585054006032 FTR1 family protein; Region: TIGR00145 585054006033 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 585054006034 Na binding site [ion binding]; other site 585054006035 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 585054006036 Predicted transcriptional regulator [Transcription]; Region: COG3905 585054006037 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 585054006038 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 585054006039 Glutamate binding site [chemical binding]; other site 585054006040 NAD binding site [chemical binding]; other site 585054006041 catalytic residues [active] 585054006042 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585054006043 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585054006044 putative acyl-acceptor binding pocket; other site 585054006045 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585054006046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585054006047 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585054006048 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 585054006049 putative active site [active] 585054006050 putative metal binding site [ion binding]; other site 585054006051 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 585054006052 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 585054006053 active site 585054006054 DNA binding site [nucleotide binding] 585054006055 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585054006056 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585054006057 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054006058 Catalytic site [active] 585054006059 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 585054006060 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 585054006061 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 585054006062 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 585054006063 flagellar motor switch protein FliG; Region: fliG; TIGR00207 585054006064 FliG C-terminal domain; Region: FliG_C; pfam01706 585054006065 flagellar assembly protein H; Validated; Region: fliH; PRK05687 585054006066 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 585054006067 Flagellar assembly protein FliH; Region: FliH; pfam02108 585054006068 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 585054006069 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585054006070 Walker A motif/ATP binding site; other site 585054006071 Walker B motif; other site 585054006072 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 585054006073 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 585054006074 flagellar hook-length control protein; Provisional; Region: PRK10118 585054006075 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 585054006076 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 585054006077 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 585054006078 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 585054006079 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 585054006080 flagellar motor switch protein; Validated; Region: fliN; PRK05698 585054006081 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 585054006082 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 585054006083 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 585054006084 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 585054006085 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 585054006086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054006087 DNA binding residues [nucleotide binding] 585054006088 dimerization interface [polypeptide binding]; other site 585054006089 hypothetical protein; Provisional; Region: PRK10708 585054006090 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 585054006091 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 585054006092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054006093 active site 585054006094 motif I; other site 585054006095 motif II; other site 585054006096 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 585054006097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054006098 metal binding site [ion binding]; metal-binding site 585054006099 active site 585054006100 I-site; other site 585054006101 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 585054006102 hypothetical protein; Provisional; Region: PRK10062 585054006103 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 585054006104 EamA-like transporter family; Region: EamA; pfam00892 585054006105 EamA-like transporter family; Region: EamA; pfam00892 585054006106 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 585054006107 additional DNA contacts [nucleotide binding]; other site 585054006108 mismatch recognition site; other site 585054006109 active site 585054006110 zinc binding site [ion binding]; other site 585054006111 DNA intercalation site [nucleotide binding]; other site 585054006112 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 585054006113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054006114 Zn2+ binding site [ion binding]; other site 585054006115 Mg2+ binding site [ion binding]; other site 585054006116 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585054006117 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054006118 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585054006119 trimer interface [polypeptide binding]; other site 585054006120 eyelet of channel; other site 585054006121 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054006122 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585054006123 trimer interface [polypeptide binding]; other site 585054006124 eyelet of channel; other site 585054006125 Cation transport protein; Region: TrkH; cl17365 585054006126 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 585054006127 chaperone protein HchA; Provisional; Region: PRK04155 585054006128 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 585054006129 conserved cys residue [active] 585054006130 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 585054006131 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 585054006132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054006133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054006134 dimerization interface [polypeptide binding]; other site 585054006135 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 585054006136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054006137 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 585054006138 putative dimerization interface [polypeptide binding]; other site 585054006139 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 585054006140 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 585054006141 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585054006142 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585054006143 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585054006144 ImpA domain protein; Region: DUF3702; pfam12486 585054006145 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 585054006146 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585054006147 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585054006148 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585054006149 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585054006150 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585054006151 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585054006152 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 585054006153 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585054006154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054006155 Walker A motif; other site 585054006156 ATP binding site [chemical binding]; other site 585054006157 Walker B motif; other site 585054006158 arginine finger; other site 585054006159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054006160 Walker A motif; other site 585054006161 ATP binding site [chemical binding]; other site 585054006162 Walker B motif; other site 585054006163 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585054006164 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 585054006165 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 585054006166 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585054006167 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 585054006168 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 585054006169 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 585054006170 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585054006171 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585054006172 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585054006173 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 585054006174 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585054006175 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585054006176 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585054006177 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585054006178 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585054006179 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585054006180 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585054006181 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 585054006182 PAAR motif; Region: PAAR_motif; pfam05488 585054006183 RHS Repeat; Region: RHS_repeat; cl11982 585054006184 RHS Repeat; Region: RHS_repeat; cl11982 585054006185 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 585054006186 RHS Repeat; Region: RHS_repeat; pfam05593 585054006187 RHS Repeat; Region: RHS_repeat; pfam05593 585054006188 RHS Repeat; Region: RHS_repeat; pfam05593 585054006189 RHS protein; Region: RHS; pfam03527 585054006190 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 585054006191 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of H repeat-associated protein (partial) 585054006192 AMP nucleosidase; Provisional; Region: PRK08292 585054006193 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 585054006194 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 585054006195 shikimate transporter; Provisional; Region: PRK09952 585054006196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054006197 putative substrate translocation pore; other site 585054006198 MATE family multidrug exporter; Provisional; Region: PRK10189 585054006199 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 585054006200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585054006201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054006202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 585054006203 DNA binding site [nucleotide binding] 585054006204 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054006205 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585054006206 Hexamer interface [polypeptide binding]; other site 585054006207 Hexagonal pore residue; other site 585054006208 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054006209 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585054006210 Hexamer interface [polypeptide binding]; other site 585054006211 Hexagonal pore residue; other site 585054006212 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054006213 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585054006214 Hexamer interface [polypeptide binding]; other site 585054006215 Hexagonal pore residue; other site 585054006216 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of fused acetaldehyde-CoA dehydrogenase ; iron-dependent alcohol dehydrogenase ; pyruvate-formate lyase deactivase (part 1) 585054006217 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 585054006218 Hexamer/Pentamer interface [polypeptide binding]; other site 585054006219 central pore; other site 585054006220 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of fused acetaldehyde-CoA dehydrogenase ; iron-dependent alcohol dehydrogenase ; pyruvate-formate lyase deactivase (part 2) 585054006221 Pyruvate formate lyase; Region: PFL; pfam02901 585054006222 Pyruvate formate lyase; Region: PFL; pfam02901 585054006223 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585054006224 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585054006225 dimer interface [polypeptide binding]; other site 585054006226 active site 585054006227 glycine loop; other site 585054006228 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585054006229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585054006230 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054006231 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585054006232 Hexamer interface [polypeptide binding]; other site 585054006233 Hexagonal pore residue; other site 585054006234 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 585054006235 Propanediol utilisation protein PduL; Region: PduL; pfam06130 585054006236 Propanediol utilisation protein PduL; Region: PduL; pfam06130 585054006237 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 585054006238 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 585054006239 L,D-transpeptidase; Provisional; Region: PRK10190 585054006240 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585054006241 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 585054006242 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 585054006243 Sensory domain found in PocR; Region: PocR; pfam10114 585054006244 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585054006245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054006246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054006247 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585054006248 amphipathic channel; other site 585054006249 Asn-Pro-Ala signature motifs; other site 585054006250 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054006251 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 585054006252 Hexamer interface [polypeptide binding]; other site 585054006253 Putative hexagonal pore residue; other site 585054006254 propanediol utilization protein PduB; Provisional; Region: PRK15415 585054006255 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 585054006256 putative hexamer interface [polypeptide binding]; other site 585054006257 putative hexagonal pore; other site 585054006258 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 585054006259 putative hexamer interface [polypeptide binding]; other site 585054006260 putative hexagonal pore; other site 585054006261 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 585054006262 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 585054006263 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 585054006264 alpha-beta subunit interface [polypeptide binding]; other site 585054006265 alpha-gamma subunit interface [polypeptide binding]; other site 585054006266 active site 585054006267 substrate and K+ binding site; other site 585054006268 K+ binding site [ion binding]; other site 585054006269 cobalamin binding site [chemical binding]; other site 585054006270 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 585054006271 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 585054006272 Cell division protein FtsA; Region: FtsA; cl17206 585054006273 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 585054006274 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 585054006275 Evidence 7 : Gene remnant; Product type ps : structure; fragment of propanediol utilization protein, polyhedral bodies (pduA-like) (partial) 585054006276 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585054006277 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 585054006278 putative hexamer interface [polypeptide binding]; other site 585054006279 putative hexagonal pore; other site 585054006280 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 585054006281 Propanediol utilisation protein PduL; Region: PduL; pfam06130 585054006282 Propanediol utilisation protein PduL; Region: PduL; pfam06130 585054006283 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 585054006284 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 585054006285 Hexamer/Pentamer interface [polypeptide binding]; other site 585054006286 central pore; other site 585054006287 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 585054006288 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 585054006289 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585054006290 putative catalytic cysteine [active] 585054006291 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 585054006292 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 585054006293 putative active site [active] 585054006294 metal binding site [ion binding]; metal-binding site 585054006295 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 585054006296 SLBB domain; Region: SLBB; pfam10531 585054006297 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 585054006298 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 585054006299 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 585054006300 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 585054006301 putative hexamer interface [polypeptide binding]; other site 585054006302 putative hexagonal pore; other site 585054006303 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 585054006304 putative hexamer interface [polypeptide binding]; other site 585054006305 putative hexagonal pore; other site 585054006306 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 585054006307 putative hexamer interface [polypeptide binding]; other site 585054006308 putative hexagonal pore; other site 585054006309 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585054006310 G1 box; other site 585054006311 GTP/Mg2+ binding site [chemical binding]; other site 585054006312 G2 box; other site 585054006313 G3 box; other site 585054006314 Switch II region; other site 585054006315 G4 box; other site 585054006316 G5 box; other site 585054006317 propionate kinase; Reviewed; Region: PRK12397 585054006318 propionate/acetate kinase; Provisional; Region: PRK12379 585054006319 hypothetical protein; Provisional; Region: PRK05423 585054006320 Predicted membrane protein [Function unknown]; Region: COG1289 585054006321 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585054006322 DNA gyrase inhibitor; Provisional; Region: PRK10016 585054006323 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 585054006324 Head binding; Region: Head_binding; pfam09008 585054006325 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 585054006326 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 585054006327 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 585054006328 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 585054006329 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 585054006330 coat protein; Region: PHA01511 585054006331 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 585054006332 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 585054006333 Terminase-like family; Region: Terminase_6; pfam03237 585054006334 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 585054006335 hypothetical protein; Region: PHA00781 585054006336 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 585054006337 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585054006338 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585054006339 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585054006340 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585054006341 catalytic residues [active] 585054006342 Antitermination protein; Region: Antiterm; pfam03589 585054006343 Antitermination protein; Region: Antiterm; pfam03589 585054006344 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585054006345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585054006346 active site 585054006347 metal binding site [ion binding]; metal-binding site 585054006348 Phage NinH protein; Region: Phage_NinH; pfam06322 585054006349 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 585054006350 NinF protein; Region: NinF; pfam05810 585054006351 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 585054006352 NinB protein; Region: NinB; pfam05772 585054006353 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585054006354 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 585054006355 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585054006356 Walker A motif; other site 585054006357 ATP binding site [chemical binding]; other site 585054006358 Walker B motif; other site 585054006359 DNA binding loops [nucleotide binding] 585054006360 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 585054006361 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585054006362 Homeodomain-like domain; Region: HTH_23; pfam13384 585054006363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054006364 non-specific DNA binding site [nucleotide binding]; other site 585054006365 salt bridge; other site 585054006366 sequence-specific DNA binding site [nucleotide binding]; other site 585054006367 Predicted transcriptional regulator [Transcription]; Region: COG2932 585054006368 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054006369 Catalytic site [active] 585054006370 Haemagglutinin-neuraminidase; Region: HN; pfam00423 585054006371 Antirestriction protein Ral; Region: Ral; pfam11058 585054006372 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 585054006373 Uncharacterized conserved protein (DUF2299); Region: DUF2299; cl02261 585054006374 ERF superfamily; Region: ERF; pfam04404 585054006375 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 585054006376 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585054006377 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585054006378 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585054006379 integrase; Provisional; Region: PRK09692 585054006380 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585054006381 active site 585054006382 Int/Topo IB signature motif; other site 585054006383 exonuclease I; Provisional; Region: sbcB; PRK11779 585054006384 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 585054006385 active site 585054006386 catalytic site [active] 585054006387 substrate binding site [chemical binding]; other site 585054006388 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 585054006389 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 585054006390 CPxP motif; other site 585054006391 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 585054006392 Sulphur transport; Region: Sulf_transp; pfam04143 585054006393 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585054006394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054006395 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585054006396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054006397 dimerization interface [polypeptide binding]; other site 585054006398 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585054006399 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 585054006400 putative NAD(P) binding site [chemical binding]; other site 585054006401 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 585054006402 antitoxin YefM; Provisional; Region: PRK11409 585054006403 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 585054006404 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 585054006405 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 585054006406 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 585054006407 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 585054006408 NAD binding site [chemical binding]; other site 585054006409 dimerization interface [polypeptide binding]; other site 585054006410 product binding site; other site 585054006411 substrate binding site [chemical binding]; other site 585054006412 zinc binding site [ion binding]; other site 585054006413 catalytic residues [active] 585054006414 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 585054006415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054006416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054006417 homodimer interface [polypeptide binding]; other site 585054006418 catalytic residue [active] 585054006419 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 585054006420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054006421 active site 585054006422 motif I; other site 585054006423 motif II; other site 585054006424 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 585054006425 putative active site pocket [active] 585054006426 4-fold oligomerization interface [polypeptide binding]; other site 585054006427 metal binding residues [ion binding]; metal-binding site 585054006428 3-fold/trimer interface [polypeptide binding]; other site 585054006429 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 585054006430 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 585054006431 putative active site [active] 585054006432 oxyanion strand; other site 585054006433 catalytic triad [active] 585054006434 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 585054006435 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 585054006436 catalytic residues [active] 585054006437 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 585054006438 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 585054006439 substrate binding site [chemical binding]; other site 585054006440 glutamase interaction surface [polypeptide binding]; other site 585054006441 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 585054006442 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 585054006443 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 585054006444 metal binding site [ion binding]; metal-binding site 585054006445 chain length determinant protein WzzB; Provisional; Region: PRK15471 585054006446 Chain length determinant protein; Region: Wzz; pfam02706 585054006447 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 585054006448 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585054006449 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585054006450 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585054006451 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585054006452 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 585054006453 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 585054006454 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585054006455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585054006456 active site 585054006457 phosphomannomutase CpsG; Provisional; Region: PRK15414 585054006458 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 585054006459 active site 585054006460 substrate binding site [chemical binding]; other site 585054006461 metal binding site [ion binding]; metal-binding site 585054006462 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 585054006463 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 585054006464 Substrate binding site; other site 585054006465 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 585054006466 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 585054006467 active site 585054006468 GDP-Mannose binding site [chemical binding]; other site 585054006469 dimer interface [polypeptide binding]; other site 585054006470 modified nudix motif 585054006471 metal binding site [ion binding]; metal-binding site 585054006472 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 585054006473 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 585054006474 NADP binding site [chemical binding]; other site 585054006475 active site 585054006476 putative substrate binding site [chemical binding]; other site 585054006477 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585054006478 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585054006479 NADP-binding site; other site 585054006480 homotetramer interface [polypeptide binding]; other site 585054006481 substrate binding site [chemical binding]; other site 585054006482 homodimer interface [polypeptide binding]; other site 585054006483 active site 585054006484 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 585054006485 GDP-Fucose binding site [chemical binding]; other site 585054006486 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 585054006487 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585054006488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585054006489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585054006490 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 585054006491 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 585054006492 trimer interface [polypeptide binding]; other site 585054006493 active site 585054006494 substrate binding site [chemical binding]; other site 585054006495 CoA binding site [chemical binding]; other site 585054006496 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585054006497 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 585054006498 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585054006499 active site 585054006500 tetramer interface; other site 585054006501 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 585054006502 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 585054006503 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 585054006504 putative ADP-binding pocket [chemical binding]; other site 585054006505 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 585054006506 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 585054006507 colanic acid exporter; Provisional; Region: PRK10459 585054006508 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 585054006509 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 585054006510 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 585054006511 phosphomannomutase CpsG; Provisional; Region: PRK15414 585054006512 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 585054006513 active site 585054006514 substrate binding site [chemical binding]; other site 585054006515 metal binding site [ion binding]; metal-binding site 585054006516 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 585054006517 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 585054006518 Substrate binding site; other site 585054006519 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 585054006520 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 585054006521 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 585054006522 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 585054006523 active site 585054006524 GDP-Mannose binding site [chemical binding]; other site 585054006525 dimer interface [polypeptide binding]; other site 585054006526 modified nudix motif 585054006527 metal binding site [ion binding]; metal-binding site 585054006528 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 585054006529 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 585054006530 NADP binding site [chemical binding]; other site 585054006531 active site 585054006532 putative substrate binding site [chemical binding]; other site 585054006533 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585054006534 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585054006535 NADP-binding site; other site 585054006536 homotetramer interface [polypeptide binding]; other site 585054006537 substrate binding site [chemical binding]; other site 585054006538 homodimer interface [polypeptide binding]; other site 585054006539 active site 585054006540 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 585054006541 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 585054006542 putative trimer interface [polypeptide binding]; other site 585054006543 putative active site [active] 585054006544 putative substrate binding site [chemical binding]; other site 585054006545 putative CoA binding site [chemical binding]; other site 585054006546 putative glycosyl transferase; Provisional; Region: PRK10063 585054006547 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 585054006548 metal-binding site 585054006549 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 585054006550 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585054006551 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 585054006552 putative acyl transferase; Provisional; Region: PRK10191 585054006553 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585054006554 trimer interface [polypeptide binding]; other site 585054006555 active site 585054006556 substrate binding site [chemical binding]; other site 585054006557 CoA binding site [chemical binding]; other site 585054006558 putative glycosyl transferase; Provisional; Region: PRK10018 585054006559 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 585054006560 active site 585054006561 tyrosine kinase; Provisional; Region: PRK11519 585054006562 Chain length determinant protein; Region: Wzz; pfam02706 585054006563 Chain length determinant protein; Region: Wzz; cl15801 585054006564 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585054006565 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585054006566 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585054006567 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585054006568 active site 585054006569 polysaccharide export protein Wza; Provisional; Region: PRK15078 585054006570 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585054006571 SLBB domain; Region: SLBB; pfam10531 585054006572 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585054006573 FOG: CBS domain [General function prediction only]; Region: COG0517 585054006574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585054006575 Transporter associated domain; Region: CorC_HlyC; smart01091 585054006576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585054006577 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585054006578 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585054006579 putative assembly protein; Provisional; Region: PRK10833 585054006580 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585054006581 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585054006582 trimer interface [polypeptide binding]; other site 585054006583 active site 585054006584 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 585054006585 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 585054006586 ATP-binding site [chemical binding]; other site 585054006587 Sugar specificity; other site 585054006588 Pyrimidine base specificity; other site 585054006589 putative diguanylate cyclase; Provisional; Region: PRK09776 585054006590 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 585054006591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054006592 putative active site [active] 585054006593 heme pocket [chemical binding]; other site 585054006594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054006595 putative active site [active] 585054006596 heme pocket [chemical binding]; other site 585054006597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054006598 putative active site [active] 585054006599 heme pocket [chemical binding]; other site 585054006600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054006601 metal binding site [ion binding]; metal-binding site 585054006602 active site 585054006603 I-site; other site 585054006604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 585054006605 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 585054006606 AlkA N-terminal domain; Region: AlkA_N; smart01009 585054006607 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585054006608 minor groove reading motif; other site 585054006609 helix-hairpin-helix signature motif; other site 585054006610 substrate binding pocket [chemical binding]; other site 585054006611 active site 585054006612 putative chaperone; Provisional; Region: PRK11678 585054006613 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 585054006614 nucleotide binding site [chemical binding]; other site 585054006615 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585054006616 SBD interface [polypeptide binding]; other site 585054006617 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 585054006618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585054006619 substrate binding site [chemical binding]; other site 585054006620 activation loop (A-loop); other site 585054006621 Y-family of DNA polymerases; Region: PolY; cl12025 585054006622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 585054006623 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 585054006624 Protein phosphatase 2C; Region: PP2C_2; pfam13672 585054006625 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 585054006626 metal ion-dependent adhesion site (MIDAS); other site 585054006627 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 585054006628 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054006629 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054006630 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 585054006631 Protein export membrane protein; Region: SecD_SecF; cl14618 585054006632 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 585054006633 putative transporter; Provisional; Region: PRK10504 585054006634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054006635 putative substrate translocation pore; other site 585054006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054006637 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 585054006638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054006639 dimerization interface [polypeptide binding]; other site 585054006640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054006641 dimer interface [polypeptide binding]; other site 585054006642 phosphorylation site [posttranslational modification] 585054006643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054006644 ATP binding site [chemical binding]; other site 585054006645 Mg2+ binding site [ion binding]; other site 585054006646 G-X-G motif; other site 585054006647 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 585054006648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054006649 active site 585054006650 phosphorylation site [posttranslational modification] 585054006651 intermolecular recognition site; other site 585054006652 dimerization interface [polypeptide binding]; other site 585054006653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054006654 DNA binding site [nucleotide binding] 585054006655 Uncharacterized conserved protein [Function unknown]; Region: COG3422 585054006656 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 585054006657 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 585054006658 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 585054006659 putative protease; Provisional; Region: PRK15452 585054006660 Peptidase family U32; Region: Peptidase_U32; pfam01136 585054006661 lipid kinase; Reviewed; Region: PRK13054 585054006662 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 585054006663 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 585054006664 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585054006665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054006666 motif II; other site 585054006667 polyol permease family; Region: 2A0118; TIGR00897 585054006668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054006669 putative substrate translocation pore; other site 585054006670 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 585054006671 N- and C-terminal domain interface [polypeptide binding]; other site 585054006672 D-xylulose kinase; Region: XylB; TIGR01312 585054006673 active site 585054006674 MgATP binding site [chemical binding]; other site 585054006675 catalytic site [active] 585054006676 metal binding site [ion binding]; metal-binding site 585054006677 xylulose binding site [chemical binding]; other site 585054006678 homodimer interface [polypeptide binding]; other site 585054006679 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054006680 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585054006681 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054006682 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585054006683 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 585054006684 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585054006685 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054006686 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054006687 DNA binding site [nucleotide binding] 585054006688 domain linker motif; other site 585054006689 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 585054006690 dimerization interface [polypeptide binding]; other site 585054006691 ligand binding site [chemical binding]; other site 585054006692 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 585054006693 classical (c) SDRs; Region: SDR_c; cd05233 585054006694 NAD(P) binding site [chemical binding]; other site 585054006695 active site 585054006696 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 585054006697 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 585054006698 N- and C-terminal domain interface [polypeptide binding]; other site 585054006699 active site 585054006700 MgATP binding site [chemical binding]; other site 585054006701 catalytic site [active] 585054006702 metal binding site [ion binding]; metal-binding site 585054006703 carbohydrate binding site [chemical binding]; other site 585054006704 putative homodimer interface [polypeptide binding]; other site 585054006705 polyol permease family; Region: 2A0118; TIGR00897 585054006706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054006707 putative substrate translocation pore; other site 585054006708 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 585054006709 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585054006710 putative active site; other site 585054006711 catalytic residue [active] 585054006712 SWIM zinc finger; Region: SWIM; pfam04434 585054006713 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 585054006714 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 585054006715 active site 585054006716 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 585054006717 dimer interface [polypeptide binding]; other site 585054006718 substrate binding site [chemical binding]; other site 585054006719 ATP binding site [chemical binding]; other site 585054006720 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 585054006721 substrate binding site [chemical binding]; other site 585054006722 multimerization interface [polypeptide binding]; other site 585054006723 ATP binding site [chemical binding]; other site 585054006724 Predicted integral membrane protein [Function unknown]; Region: COG5455 585054006725 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 585054006726 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 585054006727 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 585054006728 PapC N-terminal domain; Region: PapC_N; pfam13954 585054006729 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054006730 PapC C-terminal domain; Region: PapC_C; pfam13953 585054006731 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 585054006732 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054006733 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054006734 fimbrial chaperone protein; Provisional; Region: PRK15220 585054006735 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 585054006736 antiporter inner membrane protein; Provisional; Region: PRK11670 585054006737 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 585054006738 Walker A motif; other site 585054006739 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 585054006740 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 585054006741 active site 585054006742 HIGH motif; other site 585054006743 KMSKS motif; other site 585054006744 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 585054006745 tRNA binding surface [nucleotide binding]; other site 585054006746 anticodon binding site; other site 585054006747 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 585054006748 dimer interface [polypeptide binding]; other site 585054006749 putative tRNA-binding site [nucleotide binding]; other site 585054006750 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 585054006751 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585054006752 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 585054006753 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585054006754 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585054006755 MoxR-like ATPases [General function prediction only]; Region: COG0714 585054006756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054006757 Walker A motif; other site 585054006758 ATP binding site [chemical binding]; other site 585054006759 Walker B motif; other site 585054006760 arginine finger; other site 585054006761 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 585054006762 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585054006763 metal ion-dependent adhesion site (MIDAS); other site 585054006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 585054006765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 585054006766 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585054006767 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585054006768 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 585054006769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054006770 active site 585054006771 phosphorylation site [posttranslational modification] 585054006772 intermolecular recognition site; other site 585054006773 dimerization interface [polypeptide binding]; other site 585054006774 LytTr DNA-binding domain; Region: LytTR; pfam04397 585054006775 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585054006776 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585054006777 GAF domain; Region: GAF; pfam01590 585054006778 Histidine kinase; Region: His_kinase; pfam06580 585054006779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054006780 ATP binding site [chemical binding]; other site 585054006781 Mg2+ binding site [ion binding]; other site 585054006782 G-X-G motif; other site 585054006783 transcriptional regulator MirA; Provisional; Region: PRK15043 585054006784 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 585054006785 DNA binding residues [nucleotide binding] 585054006786 hypothetical protein; Provisional; Region: PRK13681 585054006787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054006788 putative PBP binding loops; other site 585054006789 ABC-ATPase subunit interface; other site 585054006790 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 585054006791 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 585054006792 Walker A/P-loop; other site 585054006793 ATP binding site [chemical binding]; other site 585054006794 Q-loop/lid; other site 585054006795 ABC transporter signature motif; other site 585054006796 Walker B; other site 585054006797 D-loop; other site 585054006798 H-loop/switch region; other site 585054006799 CBS domain; Region: CBS; pfam00571 585054006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054006801 dimer interface [polypeptide binding]; other site 585054006802 conserved gate region; other site 585054006803 ABC-ATPase subunit interface; other site 585054006804 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585054006805 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 585054006806 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 585054006807 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 585054006808 D-lactate dehydrogenase; Provisional; Region: PRK11183 585054006809 FAD binding domain; Region: FAD_binding_4; pfam01565 585054006810 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 585054006811 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 585054006812 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 585054006813 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 585054006814 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585054006815 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585054006816 oxidoreductase; Provisional; Region: PRK12743 585054006817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054006818 NAD(P) binding site [chemical binding]; other site 585054006819 active site 585054006820 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 585054006821 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585054006822 FMN binding site [chemical binding]; other site 585054006823 active site 585054006824 catalytic residues [active] 585054006825 substrate binding site [chemical binding]; other site 585054006826 hypothetical protein; Provisional; Region: PRK01821 585054006827 hypothetical protein; Provisional; Region: PRK10711 585054006828 cytidine deaminase; Provisional; Region: PRK09027 585054006829 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585054006830 active site 585054006831 catalytic motif [active] 585054006832 Zn binding site [ion binding]; other site 585054006833 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585054006834 active site 585054006835 catalytic motif [active] 585054006836 Zn binding site [ion binding]; other site 585054006837 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585054006838 putative active site [active] 585054006839 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 585054006840 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 585054006841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054006842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054006843 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 585054006844 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 585054006845 homodimer interface [polypeptide binding]; other site 585054006846 active site 585054006847 FMN binding site [chemical binding]; other site 585054006848 substrate binding site [chemical binding]; other site 585054006849 4Fe-4S binding domain; Region: Fer4; pfam00037 585054006850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054006851 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054006852 TM-ABC transporter signature motif; other site 585054006853 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585054006854 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 585054006855 Walker A/P-loop; other site 585054006856 ATP binding site [chemical binding]; other site 585054006857 Q-loop/lid; other site 585054006858 ABC transporter signature motif; other site 585054006859 Walker B; other site 585054006860 D-loop; other site 585054006861 H-loop/switch region; other site 585054006862 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054006863 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 585054006864 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 585054006865 ligand binding site [chemical binding]; other site 585054006866 calcium binding site [ion binding]; other site 585054006867 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 585054006868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054006869 DNA binding site [nucleotide binding] 585054006870 domain linker motif; other site 585054006871 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585054006872 dimerization interface (closed form) [polypeptide binding]; other site 585054006873 ligand binding site [chemical binding]; other site 585054006874 Predicted membrane protein [Function unknown]; Region: COG2311 585054006875 hypothetical protein; Provisional; Region: PRK10835 585054006876 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 585054006877 homodecamer interface [polypeptide binding]; other site 585054006878 GTP cyclohydrolase I; Provisional; Region: PLN03044 585054006879 active site 585054006880 putative catalytic site residues [active] 585054006881 zinc binding site [ion binding]; other site 585054006882 GTP-CH-I/GFRP interaction surface; other site 585054006883 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585054006884 S-formylglutathione hydrolase; Region: PLN02442 585054006885 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 585054006886 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585054006887 N-terminal plug; other site 585054006888 ligand-binding site [chemical binding]; other site 585054006889 lysine transporter; Provisional; Region: PRK10836 585054006890 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 585054006891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054006892 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 585054006893 putative dimerization interface [polypeptide binding]; other site 585054006894 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 585054006895 endonuclease IV; Provisional; Region: PRK01060 585054006896 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585054006897 AP (apurinic/apyrimidinic) site pocket; other site 585054006898 DNA interaction; other site 585054006899 Metal-binding active site; metal-binding site 585054006900 putative kinase; Provisional; Region: PRK09954 585054006901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054006902 putative DNA binding site [nucleotide binding]; other site 585054006903 putative Zn2+ binding site [ion binding]; other site 585054006904 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585054006905 substrate binding site [chemical binding]; other site 585054006906 ATP binding site [chemical binding]; other site 585054006907 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585054006908 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585054006909 Nucleoside recognition; Region: Gate; pfam07670 585054006910 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585054006911 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585054006912 active site 585054006913 tetramer interface [polypeptide binding]; other site 585054006914 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 585054006915 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585054006916 ligand binding site [chemical binding]; other site 585054006917 flexible hinge region; other site 585054006918 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585054006919 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585054006920 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585054006921 Nucleoside recognition; Region: Gate; pfam07670 585054006922 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585054006923 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 585054006924 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585054006925 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585054006926 substrate binding site [chemical binding]; other site 585054006927 ATP binding site [chemical binding]; other site 585054006928 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 585054006929 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 585054006930 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585054006931 active site 585054006932 P-loop; other site 585054006933 phosphorylation site [posttranslational modification] 585054006934 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 585054006935 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 585054006936 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585054006937 putative substrate binding site [chemical binding]; other site 585054006938 putative ATP binding site [chemical binding]; other site 585054006939 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 585054006940 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054006941 active site 585054006942 phosphorylation site [posttranslational modification] 585054006943 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585054006944 dimerization domain swap beta strand [polypeptide binding]; other site 585054006945 regulatory protein interface [polypeptide binding]; other site 585054006946 active site 585054006947 regulatory phosphorylation site [posttranslational modification]; other site 585054006948 sugar efflux transporter B; Provisional; Region: PRK15011 585054006949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054006950 putative substrate translocation pore; other site 585054006951 Flagellin N-methylase; Region: FliB; pfam03692 585054006952 elongation factor P; Provisional; Region: PRK04542 585054006953 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585054006954 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585054006955 RNA binding site [nucleotide binding]; other site 585054006956 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585054006957 RNA binding site [nucleotide binding]; other site 585054006958 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585054006959 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 585054006960 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054006961 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585054006962 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054006963 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054006964 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 585054006965 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 585054006966 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 585054006967 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585054006968 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585054006969 active site 585054006970 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 585054006971 NlpC/P60 family; Region: NLPC_P60; pfam00877 585054006972 phage resistance protein; Provisional; Region: PRK10551 585054006973 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585054006974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054006975 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585054006976 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 585054006977 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 585054006978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054006979 dimer interface [polypeptide binding]; other site 585054006980 conserved gate region; other site 585054006981 putative PBP binding loops; other site 585054006982 ABC-ATPase subunit interface; other site 585054006983 microcin C ABC transporter permease; Provisional; Region: PRK15021 585054006984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054006985 dimer interface [polypeptide binding]; other site 585054006986 conserved gate region; other site 585054006987 ABC-ATPase subunit interface; other site 585054006988 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 585054006989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054006990 Walker A/P-loop; other site 585054006991 ATP binding site [chemical binding]; other site 585054006992 Q-loop/lid; other site 585054006993 ABC transporter signature motif; other site 585054006994 Walker B; other site 585054006995 D-loop; other site 585054006996 H-loop/switch region; other site 585054006997 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585054006998 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054006999 Walker A/P-loop; other site 585054007000 ATP binding site [chemical binding]; other site 585054007001 Q-loop/lid; other site 585054007002 ABC transporter signature motif; other site 585054007003 Walker B; other site 585054007004 D-loop; other site 585054007005 H-loop/switch region; other site 585054007006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585054007007 hypothetical protein; Provisional; Region: PRK11835 585054007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054007009 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 585054007010 putative substrate translocation pore; other site 585054007011 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 585054007012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054007013 RNA binding surface [nucleotide binding]; other site 585054007014 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 585054007015 active site 585054007016 uracil binding [chemical binding]; other site 585054007017 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585054007018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054007019 ATP binding site [chemical binding]; other site 585054007020 putative Mg++ binding site [ion binding]; other site 585054007021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054007022 nucleotide binding region [chemical binding]; other site 585054007023 ATP-binding site [chemical binding]; other site 585054007024 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 585054007025 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 585054007026 5S rRNA interface [nucleotide binding]; other site 585054007027 CTC domain interface [polypeptide binding]; other site 585054007028 L16 interface [polypeptide binding]; other site 585054007029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585054007030 Nucleoid-associated protein [General function prediction only]; Region: COG3081 585054007031 nucleoid-associated protein NdpA; Validated; Region: PRK00378 585054007032 hypothetical protein; Provisional; Region: PRK13689 585054007033 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 585054007034 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 585054007035 Sulfatase; Region: Sulfatase; pfam00884 585054007036 transcriptional regulator NarP; Provisional; Region: PRK10403 585054007037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054007038 active site 585054007039 phosphorylation site [posttranslational modification] 585054007040 intermolecular recognition site; other site 585054007041 dimerization interface [polypeptide binding]; other site 585054007042 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054007043 DNA binding residues [nucleotide binding] 585054007044 dimerization interface [polypeptide binding]; other site 585054007045 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 585054007046 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585054007047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585054007048 binding surface 585054007049 TPR motif; other site 585054007050 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 585054007051 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 585054007052 catalytic residues [active] 585054007053 central insert; other site 585054007054 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 585054007055 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 585054007056 Heme exporter protein D (CcmD); Region: CcmD; cl11475 585054007057 heme exporter protein CcmC; Region: ccmC; TIGR01191 585054007058 heme exporter protein CcmB; Region: ccmB; TIGR01190 585054007059 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 585054007060 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 585054007061 Walker A/P-loop; other site 585054007062 ATP binding site [chemical binding]; other site 585054007063 Q-loop/lid; other site 585054007064 ABC transporter signature motif; other site 585054007065 Walker B; other site 585054007066 D-loop; other site 585054007067 H-loop/switch region; other site 585054007068 cytochrome c-type protein NapC; Provisional; Region: PRK10617 585054007069 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 585054007070 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 585054007071 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585054007072 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585054007073 4Fe-4S binding domain; Region: Fer4; cl02805 585054007074 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 585054007075 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 585054007076 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 585054007077 [4Fe-4S] binding site [ion binding]; other site 585054007078 molybdopterin cofactor binding site; other site 585054007079 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 585054007080 molybdopterin cofactor binding site; other site 585054007081 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 585054007082 ferredoxin-type protein; Provisional; Region: PRK10194 585054007083 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 585054007084 secondary substrate binding site; other site 585054007085 primary substrate binding site; other site 585054007086 inhibition loop; other site 585054007087 dimerization interface [polypeptide binding]; other site 585054007088 putative mechanosensitive channel protein; Provisional; Region: PRK11465 585054007089 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585054007090 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 585054007091 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 585054007092 hypothetical protein; Provisional; Region: PRK10259 585054007093 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 585054007094 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585054007095 N-terminal plug; other site 585054007096 ligand-binding site [chemical binding]; other site 585054007097 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 585054007098 hypothetical protein; Provisional; Region: PRK11019 585054007099 hypothetical protein; Provisional; Region: PRK10259 585054007100 putative dehydrogenase; Provisional; Region: PRK10098 585054007101 glycosyl transferase family protein; Provisional; Region: PRK08136 585054007102 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585054007103 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 585054007104 DEAD_2; Region: DEAD_2; pfam06733 585054007105 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585054007106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 585054007107 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 585054007108 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585054007109 ATP binding site [chemical binding]; other site 585054007110 Mg++ binding site [ion binding]; other site 585054007111 motif III; other site 585054007112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054007113 nucleotide binding region [chemical binding]; other site 585054007114 ATP-binding site [chemical binding]; other site 585054007115 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 585054007116 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 585054007117 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 585054007118 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054007119 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054007120 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585054007121 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585054007122 Walker A/P-loop; other site 585054007123 ATP binding site [chemical binding]; other site 585054007124 Q-loop/lid; other site 585054007125 ABC transporter signature motif; other site 585054007126 Walker B; other site 585054007127 D-loop; other site 585054007128 H-loop/switch region; other site 585054007129 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 585054007130 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585054007131 Walker A/P-loop; other site 585054007132 ATP binding site [chemical binding]; other site 585054007133 Q-loop/lid; other site 585054007134 ABC transporter signature motif; other site 585054007135 Walker B; other site 585054007136 D-loop; other site 585054007137 H-loop/switch region; other site 585054007138 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585054007139 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585054007140 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585054007141 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585054007142 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 585054007143 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 585054007144 putative catalytic site [active] 585054007145 putative metal binding site [ion binding]; other site 585054007146 putative phosphate binding site [ion binding]; other site 585054007147 cardiolipin synthase 2; Provisional; Region: PRK11263 585054007148 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 585054007149 putative active site [active] 585054007150 catalytic site [active] 585054007151 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 585054007152 putative active site [active] 585054007153 catalytic site [active] 585054007154 Predicted integral membrane protein [Function unknown]; Region: COG0392 585054007155 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 585054007156 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585054007157 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585054007158 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585054007159 Sulfatase; Region: Sulfatase; pfam00884 585054007160 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585054007161 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585054007162 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 585054007163 MoaE homodimer interface [polypeptide binding]; other site 585054007164 MoaD interaction [polypeptide binding]; other site 585054007165 active site residues [active] 585054007166 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 585054007167 MoaE interaction surface [polypeptide binding]; other site 585054007168 MoeB interaction surface [polypeptide binding]; other site 585054007169 thiocarboxylated glycine; other site 585054007170 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 585054007171 trimer interface [polypeptide binding]; other site 585054007172 dimer interface [polypeptide binding]; other site 585054007173 putative active site [active] 585054007174 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585054007175 MPT binding site; other site 585054007176 trimer interface [polypeptide binding]; other site 585054007177 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 585054007178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054007179 FeS/SAM binding site; other site 585054007180 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 585054007181 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 585054007182 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 585054007183 putative substrate binding pocket [chemical binding]; other site 585054007184 dimer interface [polypeptide binding]; other site 585054007185 phosphate binding site [ion binding]; other site 585054007186 excinuclease ABC subunit B; Provisional; Region: PRK05298 585054007187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054007188 ATP binding site [chemical binding]; other site 585054007189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054007190 nucleotide binding region [chemical binding]; other site 585054007191 ATP-binding site [chemical binding]; other site 585054007192 Ultra-violet resistance protein B; Region: UvrB; pfam12344 585054007193 UvrB/uvrC motif; Region: UVR; pfam02151 585054007194 AAA domain; Region: AAA_26; pfam13500 585054007195 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585054007196 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 585054007197 ADP binding site [chemical binding]; other site 585054007198 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 585054007199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054007200 S-adenosylmethionine binding site [chemical binding]; other site 585054007201 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585054007202 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585054007203 substrate-cofactor binding pocket; other site 585054007204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054007205 catalytic residue [active] 585054007206 biotin synthase; Provisional; Region: PRK15108 585054007207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054007208 FeS/SAM binding site; other site 585054007209 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 585054007210 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 585054007211 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585054007212 inhibitor-cofactor binding pocket; inhibition site 585054007213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054007214 catalytic residue [active] 585054007215 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585054007216 substrate binding site [chemical binding]; other site 585054007217 acyl-CoA thioesterase; Provisional; Region: PRK10531 585054007218 putative pectinesterase; Region: PLN02432; cl01911 585054007219 6-phosphogluconolactonase; Provisional; Region: PRK11028 585054007220 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 585054007221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054007222 motif II; other site 585054007223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054007224 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 585054007225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054007226 Walker A/P-loop; other site 585054007227 ATP binding site [chemical binding]; other site 585054007228 Q-loop/lid; other site 585054007229 ABC transporter signature motif; other site 585054007230 Walker B; other site 585054007231 D-loop; other site 585054007232 H-loop/switch region; other site 585054007233 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585054007234 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585054007235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054007236 putative PBP binding loops; other site 585054007237 ABC-ATPase subunit interface; other site 585054007238 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 585054007239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054007240 substrate binding pocket [chemical binding]; other site 585054007241 membrane-bound complex binding site; other site 585054007242 hinge residues; other site 585054007243 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 585054007244 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 585054007245 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 585054007246 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585054007247 TOBE domain; Region: TOBE; pfam03459 585054007248 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 585054007249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 585054007250 Walker A/P-loop; other site 585054007251 ATP binding site [chemical binding]; other site 585054007252 Q-loop/lid; other site 585054007253 ABC transporter signature motif; other site 585054007254 Walker B; other site 585054007255 D-loop; other site 585054007256 H-loop/switch region; other site 585054007257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054007258 Walker A/P-loop; other site 585054007259 ATP binding site [chemical binding]; other site 585054007260 Q-loop/lid; other site 585054007261 ABC transporter signature motif; other site 585054007262 Walker B; other site 585054007263 D-loop; other site 585054007264 H-loop/switch region; other site 585054007265 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 585054007266 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 585054007267 NAD binding site [chemical binding]; other site 585054007268 homodimer interface [polypeptide binding]; other site 585054007269 active site 585054007270 substrate binding site [chemical binding]; other site 585054007271 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 585054007272 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 585054007273 dimer interface [polypeptide binding]; other site 585054007274 active site 585054007275 galactokinase; Provisional; Region: PRK05101 585054007276 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 585054007277 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585054007278 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 585054007279 active site 585054007280 catalytic residues [active] 585054007281 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585054007282 catalytic core [active] 585054007283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585054007284 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 585054007285 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585054007286 YbgS-like protein; Region: YbgS; pfam13985 585054007287 zinc transporter ZitB; Provisional; Region: PRK03557 585054007288 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 585054007289 quinolinate synthetase; Provisional; Region: PRK09375 585054007290 tol-pal system protein YbgF; Provisional; Region: PRK10803 585054007291 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585054007292 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585054007293 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 585054007294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585054007295 ligand binding site [chemical binding]; other site 585054007296 translocation protein TolB; Provisional; Region: tolB; PRK03629 585054007297 TolB amino-terminal domain; Region: TolB_N; pfam04052 585054007298 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585054007299 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585054007300 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585054007301 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585054007302 TolA C-terminal; Region: TolA; pfam06519 585054007303 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585054007304 colicin uptake protein TolR; Provisional; Region: PRK11024 585054007305 colicin uptake protein TolQ; Provisional; Region: PRK10801 585054007306 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585054007307 active site 585054007308 hypothetical protein; Provisional; Region: PRK10588 585054007309 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 585054007310 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 585054007311 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585054007312 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 585054007313 alpha-mannosidase; Provisional; Region: PRK09819 585054007314 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 585054007315 active site 585054007316 metal binding site [ion binding]; metal-binding site 585054007317 catalytic site [active] 585054007318 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 585054007319 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 585054007320 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054007321 active site 585054007322 phosphorylation site [posttranslational modification] 585054007323 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585054007324 active site 585054007325 P-loop; other site 585054007326 phosphorylation site [posttranslational modification] 585054007327 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585054007328 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 585054007329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054007330 DNA-binding site [nucleotide binding]; DNA binding site 585054007331 UTRA domain; Region: UTRA; pfam07702 585054007332 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 585054007333 B12 binding site [chemical binding]; other site 585054007334 heterodimer interface [polypeptide binding]; other site 585054007335 cobalt ligand [ion binding]; other site 585054007336 conserved hypothetical protein; Region: glmL_fam; TIGR01319 585054007337 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 585054007338 substrate binding site [chemical binding]; other site 585054007339 B12 cofactor binding site [chemical binding]; other site 585054007340 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 585054007341 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 585054007342 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 585054007343 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 585054007344 dimer interface [polypeptide binding]; other site 585054007345 active site 585054007346 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 585054007347 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 585054007348 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 585054007349 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585054007350 putative fumarate hydratase; Provisional; Region: PRK15392 585054007351 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585054007352 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585054007353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054007354 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 585054007355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054007356 dimerization interface [polypeptide binding]; other site 585054007357 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585054007358 CoA binding domain; Region: CoA_binding; smart00881 585054007359 CoA-ligase; Region: Ligase_CoA; pfam00549 585054007360 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585054007361 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585054007362 CoA-ligase; Region: Ligase_CoA; pfam00549 585054007363 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585054007364 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585054007365 E3 interaction surface; other site 585054007366 lipoyl attachment site [posttranslational modification]; other site 585054007367 e3 binding domain; Region: E3_binding; pfam02817 585054007368 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585054007369 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 585054007370 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 585054007371 TPP-binding site [chemical binding]; other site 585054007372 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 585054007373 dimer interface [polypeptide binding]; other site 585054007374 PYR/PP interface [polypeptide binding]; other site 585054007375 TPP binding site [chemical binding]; other site 585054007376 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 585054007377 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585054007378 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 585054007379 L-aspartate oxidase; Provisional; Region: PRK06175 585054007380 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585054007381 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 585054007382 SdhC subunit interface [polypeptide binding]; other site 585054007383 proximal heme binding site [chemical binding]; other site 585054007384 cardiolipin binding site; other site 585054007385 Iron-sulfur protein interface; other site 585054007386 proximal quinone binding site [chemical binding]; other site 585054007387 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 585054007388 Iron-sulfur protein interface; other site 585054007389 proximal quinone binding site [chemical binding]; other site 585054007390 SdhD (CybS) interface [polypeptide binding]; other site 585054007391 proximal heme binding site [chemical binding]; other site 585054007392 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 585054007393 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585054007394 dimer interface [polypeptide binding]; other site 585054007395 active site 585054007396 citrylCoA binding site [chemical binding]; other site 585054007397 NADH binding [chemical binding]; other site 585054007398 cationic pore residues; other site 585054007399 oxalacetate/citrate binding site [chemical binding]; other site 585054007400 coenzyme A binding site [chemical binding]; other site 585054007401 catalytic triad [active] 585054007402 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585054007403 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585054007404 PapC N-terminal domain; Region: PapC_N; pfam13954 585054007405 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054007406 PapC C-terminal domain; Region: PapC_C; pfam13953 585054007407 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585054007408 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054007409 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054007410 Fimbrial protein; Region: Fimbrial; pfam00419 585054007411 Putative ammonia monooxygenase; Region: AmoA; pfam05145 585054007412 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585054007413 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585054007414 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 585054007415 putative substrate binding pocket [chemical binding]; other site 585054007416 AC domain interface; other site 585054007417 catalytic triad [active] 585054007418 AB domain interface; other site 585054007419 interchain disulfide; other site 585054007420 Predicted membrane protein [Function unknown]; Region: COG3817 585054007421 Protein of unknown function (DUF979); Region: DUF979; pfam06166 585054007422 Protein of unknown function (DUF969); Region: DUF969; pfam06149 585054007423 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 585054007424 putative active site [active] 585054007425 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 585054007426 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 585054007427 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 585054007428 Uncharacterized conserved protein [Function unknown]; Region: COG0327 585054007429 metal-binding protein; Provisional; Region: PRK10799 585054007430 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585054007431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054007432 putative substrate translocation pore; other site 585054007433 POT family; Region: PTR2; pfam00854 585054007434 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 585054007435 DNA photolyase; Region: DNA_photolyase; pfam00875 585054007436 hypothetical protein; Provisional; Region: PRK10167 585054007437 Uncharacterized conserved protein [Function unknown]; Region: COG3272 585054007438 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 585054007439 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 585054007440 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 585054007441 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585054007442 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 585054007443 sensor protein KdpD; Provisional; Region: PRK10490 585054007444 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 585054007445 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 585054007446 Ligand Binding Site [chemical binding]; other site 585054007447 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 585054007448 GAF domain; Region: GAF_3; pfam13492 585054007449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054007450 dimer interface [polypeptide binding]; other site 585054007451 phosphorylation site [posttranslational modification] 585054007452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054007453 ATP binding site [chemical binding]; other site 585054007454 Mg2+ binding site [ion binding]; other site 585054007455 G-X-G motif; other site 585054007456 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 585054007457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054007458 active site 585054007459 phosphorylation site [posttranslational modification] 585054007460 intermolecular recognition site; other site 585054007461 dimerization interface [polypeptide binding]; other site 585054007462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054007463 DNA binding site [nucleotide binding] 585054007464 ornithine decarboxylase; Provisional; Region: PRK13578 585054007465 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585054007466 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585054007467 homodimer interface [polypeptide binding]; other site 585054007468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054007469 catalytic residue [active] 585054007470 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585054007471 putrescine transporter; Provisional; Region: potE; PRK10655 585054007472 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 585054007473 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 585054007474 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 585054007475 active site 585054007476 substrate binding site [chemical binding]; other site 585054007477 metal binding site [ion binding]; metal-binding site 585054007478 replication initiation regulator SeqA; Provisional; Region: PRK11187 585054007479 acyl-CoA esterase; Provisional; Region: PRK10673 585054007480 PGAP1-like protein; Region: PGAP1; pfam07819 585054007481 LexA regulated protein; Provisional; Region: PRK11675 585054007482 flavodoxin FldA; Validated; Region: PRK09267 585054007483 ferric uptake regulator; Provisional; Region: fur; PRK09462 585054007484 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585054007485 metal binding site 2 [ion binding]; metal-binding site 585054007486 putative DNA binding helix; other site 585054007487 metal binding site 1 [ion binding]; metal-binding site 585054007488 dimer interface [polypeptide binding]; other site 585054007489 structural Zn2+ binding site [ion binding]; other site 585054007490 YbfN-like lipoprotein; Region: YbfN; pfam13982 585054007491 outer membrane porin, OprD family; Region: OprD; pfam03573 585054007492 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 585054007493 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585054007494 active site 585054007495 HIGH motif; other site 585054007496 nucleotide binding site [chemical binding]; other site 585054007497 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 585054007498 KMSKS motif; other site 585054007499 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 585054007500 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 585054007501 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585054007502 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054007503 active site turn [active] 585054007504 phosphorylation site [posttranslational modification] 585054007505 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585054007506 HPr interaction site; other site 585054007507 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585054007508 active site 585054007509 phosphorylation site [posttranslational modification] 585054007510 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585054007511 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585054007512 active site 585054007513 trimer interface [polypeptide binding]; other site 585054007514 allosteric site; other site 585054007515 active site lid [active] 585054007516 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585054007517 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 585054007518 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585054007519 active site 585054007520 dimer interface [polypeptide binding]; other site 585054007521 MarR family; Region: MarR; pfam01047 585054007522 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585054007523 ROK family; Region: ROK; pfam00480 585054007524 UMP phosphatase; Provisional; Region: PRK10444 585054007525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054007526 active site 585054007527 motif I; other site 585054007528 motif II; other site 585054007529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054007530 asparagine synthetase B; Provisional; Region: asnB; PRK09431 585054007531 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 585054007532 active site 585054007533 dimer interface [polypeptide binding]; other site 585054007534 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 585054007535 Ligand Binding Site [chemical binding]; other site 585054007536 Molecular Tunnel; other site 585054007537 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 585054007538 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585054007539 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 585054007540 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585054007541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054007542 FeS/SAM binding site; other site 585054007543 TRAM domain; Region: TRAM; pfam01938 585054007544 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585054007545 PhoH-like protein; Region: PhoH; pfam02562 585054007546 metal-binding heat shock protein; Provisional; Region: PRK00016 585054007547 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 585054007548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585054007549 Transporter associated domain; Region: CorC_HlyC; smart01091 585054007550 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 585054007551 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 585054007552 putative active site [active] 585054007553 catalytic triad [active] 585054007554 putative dimer interface [polypeptide binding]; other site 585054007555 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585054007556 Uncharacterized conserved protein [Function unknown]; Region: COG3391 585054007557 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585054007558 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585054007559 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585054007560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054007561 substrate binding pocket [chemical binding]; other site 585054007562 membrane-bound complex binding site; other site 585054007563 hinge residues; other site 585054007564 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054007565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054007566 dimer interface [polypeptide binding]; other site 585054007567 conserved gate region; other site 585054007568 putative PBP binding loops; other site 585054007569 ABC-ATPase subunit interface; other site 585054007570 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054007571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054007572 dimer interface [polypeptide binding]; other site 585054007573 conserved gate region; other site 585054007574 putative PBP binding loops; other site 585054007575 ABC-ATPase subunit interface; other site 585054007576 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585054007577 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585054007578 Walker A/P-loop; other site 585054007579 ATP binding site [chemical binding]; other site 585054007580 Q-loop/lid; other site 585054007581 ABC transporter signature motif; other site 585054007582 Walker B; other site 585054007583 D-loop; other site 585054007584 H-loop/switch region; other site 585054007585 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585054007586 active site 585054007587 tetramer interface [polypeptide binding]; other site 585054007588 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 585054007589 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 585054007590 nucleotide binding site [chemical binding]; other site 585054007591 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585054007592 SBD interface [polypeptide binding]; other site 585054007593 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 585054007594 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585054007595 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054007596 Sel1-like repeats; Region: SEL1; smart00671 585054007597 Sel1-like repeats; Region: SEL1; smart00671 585054007598 Sel1-like repeats; Region: SEL1; smart00671 585054007599 Evidence 7 : Gene remnant; Product type pf : factor; fragment of DnaJ-class chaperone (part 2) 585054007600 putative transposase OrfB; Reviewed; Region: PHA02517 585054007601 HTH-like domain; Region: HTH_21; pfam13276 585054007602 Integrase core domain; Region: rve; pfam00665 585054007603 Integrase core domain; Region: rve_2; pfam13333 585054007604 Transposase; Region: HTH_Tnp_1; cl17663 585054007605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585054007606 Evidence 7 : Gene remnant; Product type pf : factor; fragment of DnaJ-class chaperone (part 1) 585054007607 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585054007608 Sel1-like repeats; Region: SEL1; smart00671 585054007609 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054007610 Sel1-like repeats; Region: SEL1; smart00671 585054007611 Sel1-like repeats; Region: SEL1; smart00671 585054007612 Sel1-like repeats; Region: SEL1; smart00671 585054007613 Sel1-like repeats; Region: SEL1; smart00671 585054007614 Sel1-like repeats; Region: SEL1; smart00671 585054007615 Sel1-like repeats; Region: SEL1; smart00671 585054007616 hypothetical protein; Provisional; Region: PRK11032 585054007617 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 585054007618 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 585054007619 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 585054007620 HIGH motif; other site 585054007621 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585054007622 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585054007623 active site 585054007624 KMSKS motif; other site 585054007625 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 585054007626 tRNA binding surface [nucleotide binding]; other site 585054007627 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 585054007628 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 585054007629 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 585054007630 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 585054007631 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 585054007632 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 585054007633 active site 585054007634 (T/H)XGH motif; other site 585054007635 ribosome-associated protein; Provisional; Region: PRK11538 585054007636 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 585054007637 penicillin-binding protein 2; Provisional; Region: PRK10795 585054007638 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585054007639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585054007640 cell wall shape-determining protein; Provisional; Region: PRK10794 585054007641 rare lipoprotein A; Provisional; Region: PRK10672 585054007642 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 585054007643 Sporulation related domain; Region: SPOR; pfam05036 585054007644 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 585054007645 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585054007646 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585054007647 hypothetical protein; Provisional; Region: PRK04998 585054007648 lipoate-protein ligase B; Provisional; Region: PRK14342 585054007649 lipoyl synthase; Provisional; Region: PRK05481 585054007650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054007651 FeS/SAM binding site; other site 585054007652 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 585054007653 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585054007654 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 585054007655 putative active site [active] 585054007656 catalytic triad [active] 585054007657 putative dimer interface [polypeptide binding]; other site 585054007658 chromosome condensation membrane protein; Provisional; Region: PRK14196 585054007659 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054007660 DNA-binding site [nucleotide binding]; DNA binding site 585054007661 RNA-binding motif; other site 585054007662 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 585054007663 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 585054007664 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585054007665 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 585054007666 B1 nucleotide binding pocket [chemical binding]; other site 585054007667 B2 nucleotide binding pocket [chemical binding]; other site 585054007668 CAS motifs; other site 585054007669 active site 585054007670 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 585054007671 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585054007672 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054007673 Ligand Binding Site [chemical binding]; other site 585054007674 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 585054007675 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 585054007676 catalytic residue [active] 585054007677 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 585054007678 catalytic residues [active] 585054007679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054007680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054007681 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 585054007682 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 585054007683 dimer interface [polypeptide binding]; other site 585054007684 decamer (pentamer of dimers) interface [polypeptide binding]; other site 585054007685 catalytic triad [active] 585054007686 peroxidatic and resolving cysteines [active] 585054007687 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 585054007688 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585054007689 dimerization domain [polypeptide binding]; other site 585054007690 dimer interface [polypeptide binding]; other site 585054007691 catalytic residues [active] 585054007692 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585054007693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054007694 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585054007695 dimerization interface [polypeptide binding]; other site 585054007696 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 585054007697 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585054007698 Active Sites [active] 585054007699 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 585054007700 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 585054007701 ParB-like nuclease domain; Region: ParBc; pfam02195 585054007702 methionine aminotransferase; Validated; Region: PRK09082 585054007703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054007704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054007705 homodimer interface [polypeptide binding]; other site 585054007706 catalytic residue [active] 585054007707 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585054007708 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 585054007709 putative active site [active] 585054007710 metal binding site [ion binding]; metal-binding site 585054007711 Uncharacterized small protein [Function unknown]; Region: COG2879 585054007712 carbon starvation protein A; Provisional; Region: PRK15015 585054007713 Carbon starvation protein CstA; Region: CstA; pfam02554 585054007714 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585054007715 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585054007716 CoenzymeA binding site [chemical binding]; other site 585054007717 subunit interaction site [polypeptide binding]; other site 585054007718 PHB binding site; other site 585054007719 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 585054007720 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 585054007721 putative NAD(P) binding site [chemical binding]; other site 585054007722 active site 585054007723 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 585054007724 hydrophobic substrate binding pocket; other site 585054007725 Isochorismatase family; Region: Isochorismatase; pfam00857 585054007726 active site 585054007727 conserved cis-peptide bond; other site 585054007728 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585054007729 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 585054007730 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585054007731 acyl-activating enzyme (AAE) consensus motif; other site 585054007732 active site 585054007733 AMP binding site [chemical binding]; other site 585054007734 substrate binding site [chemical binding]; other site 585054007735 isochorismate synthase EntC; Provisional; Region: PRK15016 585054007736 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585054007737 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 585054007738 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585054007739 siderophore binding site; other site 585054007740 enterobactin exporter EntS; Provisional; Region: PRK10489 585054007741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054007742 putative substrate translocation pore; other site 585054007743 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585054007744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585054007745 ABC-ATPase subunit interface; other site 585054007746 dimer interface [polypeptide binding]; other site 585054007747 putative PBP binding regions; other site 585054007748 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585054007749 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585054007750 ABC-ATPase subunit interface; other site 585054007751 dimer interface [polypeptide binding]; other site 585054007752 putative PBP binding regions; other site 585054007753 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 585054007754 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585054007755 Walker A/P-loop; other site 585054007756 ATP binding site [chemical binding]; other site 585054007757 Q-loop/lid; other site 585054007758 ABC transporter signature motif; other site 585054007759 Walker B; other site 585054007760 D-loop; other site 585054007761 H-loop/switch region; other site 585054007762 LPS O-antigen length regulator; Provisional; Region: PRK10381 585054007763 Chain length determinant protein; Region: Wzz; pfam02706 585054007764 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 585054007765 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 585054007766 acyl-activating enzyme (AAE) consensus motif; other site 585054007767 AMP binding site [chemical binding]; other site 585054007768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585054007769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 585054007770 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 585054007771 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 585054007772 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585054007773 outer membrane receptor FepA; Provisional; Region: PRK13524 585054007774 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585054007775 N-terminal plug; other site 585054007776 ligand-binding site [chemical binding]; other site 585054007777 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 585054007778 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 585054007779 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 585054007780 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585054007781 PYR/PP interface [polypeptide binding]; other site 585054007782 dimer interface [polypeptide binding]; other site 585054007783 TPP binding site [chemical binding]; other site 585054007784 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585054007785 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585054007786 TPP-binding site [chemical binding]; other site 585054007787 dimer interface [polypeptide binding]; other site 585054007788 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585054007789 MarR family; Region: MarR_2; cl17246 585054007790 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585054007791 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 585054007792 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 585054007793 N- and C-terminal domain interface [polypeptide binding]; other site 585054007794 active site 585054007795 MgATP binding site [chemical binding]; other site 585054007796 catalytic site [active] 585054007797 metal binding site [ion binding]; metal-binding site 585054007798 putative homotetramer interface [polypeptide binding]; other site 585054007799 putative homodimer interface [polypeptide binding]; other site 585054007800 glycerol binding site [chemical binding]; other site 585054007801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 585054007802 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585054007803 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 585054007804 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585054007805 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585054007806 Walker A/P-loop; other site 585054007807 ATP binding site [chemical binding]; other site 585054007808 Q-loop/lid; other site 585054007809 ABC transporter signature motif; other site 585054007810 Walker B; other site 585054007811 D-loop; other site 585054007812 H-loop/switch region; other site 585054007813 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054007814 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054007815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054007816 TM-ABC transporter signature motif; other site 585054007817 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 585054007818 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 585054007819 NAD binding site [chemical binding]; other site 585054007820 homotetramer interface [polypeptide binding]; other site 585054007821 homodimer interface [polypeptide binding]; other site 585054007822 active site 585054007823 substrate binding site [chemical binding]; other site 585054007824 short chain dehydrogenase; Provisional; Region: PRK06114 585054007825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054007826 NAD(P) binding site [chemical binding]; other site 585054007827 active site 585054007828 Hok/gef family; Region: HOK_GEF; pfam01848 585054007829 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 585054007830 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 585054007831 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 585054007832 hypothetical protein; Provisional; Region: PRK10250 585054007833 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 585054007834 dimer interface [polypeptide binding]; other site 585054007835 FMN binding site [chemical binding]; other site 585054007836 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585054007837 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585054007838 phenylalanine transporter; Provisional; Region: PRK10249 585054007839 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 585054007840 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 585054007841 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054007842 periplasmic copper-binding protein; Provisional; Region: PRK09838 585054007843 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 585054007844 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 585054007845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054007846 active site 585054007847 phosphorylation site [posttranslational modification] 585054007848 intermolecular recognition site; other site 585054007849 dimerization interface [polypeptide binding]; other site 585054007850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054007851 DNA binding site [nucleotide binding] 585054007852 sensor kinase CusS; Provisional; Region: PRK09835 585054007853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054007854 dimerization interface [polypeptide binding]; other site 585054007855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054007856 dimer interface [polypeptide binding]; other site 585054007857 phosphorylation site [posttranslational modification] 585054007858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054007859 ATP binding site [chemical binding]; other site 585054007860 Mg2+ binding site [ion binding]; other site 585054007861 G-X-G motif; other site 585054007862 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 585054007863 heat shock protein 90; Provisional; Region: PRK05218 585054007864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054007865 ATP binding site [chemical binding]; other site 585054007866 Mg2+ binding site [ion binding]; other site 585054007867 G-X-G motif; other site 585054007868 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 585054007869 RecR protein; Region: RecR; pfam02132 585054007870 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 585054007871 putative active site [active] 585054007872 putative metal-binding site [ion binding]; other site 585054007873 tetramer interface [polypeptide binding]; other site 585054007874 hypothetical protein; Validated; Region: PRK00153 585054007875 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 585054007876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054007877 Walker A motif; other site 585054007878 ATP binding site [chemical binding]; other site 585054007879 Walker B motif; other site 585054007880 DNA polymerase III subunit delta'; Validated; Region: PRK08485 585054007881 arginine finger; other site 585054007882 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 585054007883 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 585054007884 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 585054007885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054007886 active site 585054007887 hypothetical protein; Provisional; Region: PRK10527 585054007888 primosomal replication protein N''; Provisional; Region: PRK10093 585054007889 hypothetical protein; Provisional; Region: PRK11038 585054007890 hypothetical protein; Provisional; Region: PRK11281 585054007891 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585054007892 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 585054007893 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585054007894 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 585054007895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054007896 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585054007897 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585054007898 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054007899 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054007900 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585054007901 Protein export membrane protein; Region: SecD_SecF; cl14618 585054007902 Protein export membrane protein; Region: SecD_SecF; cl14618 585054007903 Hha toxicity attenuator; Provisional; Region: PRK10667 585054007904 gene expression modulator; Provisional; Region: PRK10945 585054007905 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 585054007906 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585054007907 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585054007908 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054007909 Uncharacterized conserved protein [Function unknown]; Region: COG5507 585054007910 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 585054007911 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585054007912 DNA binding site [nucleotide binding] 585054007913 active site 585054007914 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585054007915 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 585054007916 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054007917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 585054007918 acyl-CoA thioesterase II; Provisional; Region: PRK10526 585054007919 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 585054007920 active site 585054007921 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 585054007922 catalytic triad [active] 585054007923 dimer interface [polypeptide binding]; other site 585054007924 ammonium transporter; Provisional; Region: PRK10666 585054007925 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 585054007926 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585054007927 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 585054007928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054007929 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 585054007930 Walker A/P-loop; other site 585054007931 ATP binding site [chemical binding]; other site 585054007932 Q-loop/lid; other site 585054007933 ABC transporter signature motif; other site 585054007934 Walker B; other site 585054007935 D-loop; other site 585054007936 H-loop/switch region; other site 585054007937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054007938 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 585054007939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054007940 Walker A/P-loop; other site 585054007941 ATP binding site [chemical binding]; other site 585054007942 Q-loop/lid; other site 585054007943 ABC transporter signature motif; other site 585054007944 Walker B; other site 585054007945 D-loop; other site 585054007946 H-loop/switch region; other site 585054007947 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 585054007948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054007949 putative DNA binding site [nucleotide binding]; other site 585054007950 putative Zn2+ binding site [ion binding]; other site 585054007951 AsnC family; Region: AsnC_trans_reg; pfam01037 585054007952 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 585054007953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054007954 active site 585054007955 motif I; other site 585054007956 motif II; other site 585054007957 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 585054007958 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585054007959 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 585054007960 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 585054007961 Ligand Binding Site [chemical binding]; other site 585054007962 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585054007963 active site 585054007964 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 585054007965 periplasmic folding chaperone; Provisional; Region: PRK10788 585054007966 SurA N-terminal domain; Region: SurA_N_3; cl07813 585054007967 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 585054007968 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585054007969 IHF dimer interface [polypeptide binding]; other site 585054007970 IHF - DNA interface [nucleotide binding]; other site 585054007971 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 585054007972 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585054007973 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585054007974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054007975 Walker A motif; other site 585054007976 ATP binding site [chemical binding]; other site 585054007977 Walker B motif; other site 585054007978 arginine finger; other site 585054007979 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585054007980 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 585054007981 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 585054007982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054007983 Walker A motif; other site 585054007984 ATP binding site [chemical binding]; other site 585054007985 Walker B motif; other site 585054007986 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585054007987 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585054007988 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 585054007989 oligomer interface [polypeptide binding]; other site 585054007990 active site residues [active] 585054007991 trigger factor; Provisional; Region: tig; PRK01490 585054007992 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585054007993 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 585054007994 transcriptional regulator BolA; Provisional; Region: PRK11628 585054007995 hypothetical protein; Provisional; Region: PRK11627 585054007996 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 585054007997 muropeptide transporter; Reviewed; Region: ampG; PRK11902 585054007998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054007999 putative substrate translocation pore; other site 585054008000 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 585054008001 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 585054008002 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 585054008003 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 585054008004 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 585054008005 D-pathway; other site 585054008006 Putative ubiquinol binding site [chemical binding]; other site 585054008007 Low-spin heme (heme b) binding site [chemical binding]; other site 585054008008 Putative water exit pathway; other site 585054008009 Binuclear center (heme o3/CuB) [ion binding]; other site 585054008010 K-pathway; other site 585054008011 Putative proton exit pathway; other site 585054008012 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 585054008013 Subunit I/III interface [polypeptide binding]; other site 585054008014 Subunit III/IV interface [polypeptide binding]; other site 585054008015 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 585054008016 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 585054008017 UbiA prenyltransferase family; Region: UbiA; pfam01040 585054008018 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054008019 Sel1-like repeats; Region: SEL1; smart00671 585054008020 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054008021 Sel1-like repeats; Region: SEL1; smart00671 585054008022 Sel1-like repeats; Region: SEL1; smart00671 585054008023 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 585054008024 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585054008025 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054008026 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 585054008027 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585054008028 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585054008029 shikimate binding site; other site 585054008030 NAD(P) binding site [chemical binding]; other site 585054008031 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 585054008032 Predicted oxidoreductase [General function prediction only]; Region: COG3573 585054008033 NIPSNAP; Region: NIPSNAP; pfam07978 585054008034 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 585054008035 Predicted oxidoreductase [General function prediction only]; Region: COG3573 585054008036 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585054008037 tRNA ribose 2'-O-methyltransferase, aTrm56; Region: Trm56; cl17473 585054008038 benzoate transport; Region: 2A0115; TIGR00895 585054008039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054008040 putative substrate translocation pore; other site 585054008041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054008042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585054008043 putative substrate translocation pore; other site 585054008044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 585054008045 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 585054008046 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 585054008047 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585054008048 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 585054008049 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 585054008050 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 585054008051 conserved cys residue [active] 585054008052 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 585054008053 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 585054008054 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 585054008055 Ligand Binding Site [chemical binding]; other site 585054008056 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585054008057 active site residue [active] 585054008058 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 585054008059 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585054008060 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585054008061 substrate binding pocket [chemical binding]; other site 585054008062 chain length determination region; other site 585054008063 substrate-Mg2+ binding site; other site 585054008064 catalytic residues [active] 585054008065 aspartate-rich region 1; other site 585054008066 active site lid residues [active] 585054008067 aspartate-rich region 2; other site 585054008068 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 585054008069 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 585054008070 TPP-binding site; other site 585054008071 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585054008072 PYR/PP interface [polypeptide binding]; other site 585054008073 dimer interface [polypeptide binding]; other site 585054008074 TPP binding site [chemical binding]; other site 585054008075 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585054008076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054008077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054008078 active site 585054008079 catalytic tetrad [active] 585054008080 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 585054008081 tetramer interfaces [polypeptide binding]; other site 585054008082 binuclear metal-binding site [ion binding]; other site 585054008083 thiamine monophosphate kinase; Provisional; Region: PRK05731 585054008084 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 585054008085 ATP binding site [chemical binding]; other site 585054008086 dimerization interface [polypeptide binding]; other site 585054008087 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 585054008088 putative RNA binding site [nucleotide binding]; other site 585054008089 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 585054008090 homopentamer interface [polypeptide binding]; other site 585054008091 active site 585054008092 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 585054008093 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 585054008094 catalytic motif [active] 585054008095 Zn binding site [ion binding]; other site 585054008096 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 585054008097 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 585054008098 ATP cone domain; Region: ATP-cone; pfam03477 585054008099 hypothetical protein; Provisional; Region: PRK11530 585054008100 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 585054008101 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585054008102 active site 585054008103 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 585054008104 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585054008105 Protein export membrane protein; Region: SecD_SecF; pfam02355 585054008106 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 585054008107 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 585054008108 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585054008109 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 585054008110 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 585054008111 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 585054008112 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 585054008113 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 585054008114 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 585054008115 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 585054008116 maltodextrin glucosidase; Provisional; Region: PRK10785 585054008117 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 585054008118 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 585054008119 active site 585054008120 homodimer interface [polypeptide binding]; other site 585054008121 catalytic site [active] 585054008122 putative proline-specific permease; Provisional; Region: proY; PRK10580 585054008123 Spore germination protein; Region: Spore_permease; cl17796 585054008124 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 585054008125 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 585054008126 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 585054008127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054008128 putative active site [active] 585054008129 heme pocket [chemical binding]; other site 585054008130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054008131 dimer interface [polypeptide binding]; other site 585054008132 phosphorylation site [posttranslational modification] 585054008133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054008134 ATP binding site [chemical binding]; other site 585054008135 Mg2+ binding site [ion binding]; other site 585054008136 G-X-G motif; other site 585054008137 transcriptional regulator PhoB; Provisional; Region: PRK10161 585054008138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054008139 active site 585054008140 phosphorylation site [posttranslational modification] 585054008141 intermolecular recognition site; other site 585054008142 dimerization interface [polypeptide binding]; other site 585054008143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054008144 DNA binding site [nucleotide binding] 585054008145 exonuclease subunit SbcD; Provisional; Region: PRK10966 585054008146 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 585054008147 active site 585054008148 metal binding site [ion binding]; metal-binding site 585054008149 DNA binding site [nucleotide binding] 585054008150 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 585054008151 exonuclease subunit SbcC; Provisional; Region: PRK10246 585054008152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054008153 Walker A/P-loop; other site 585054008154 ATP binding site [chemical binding]; other site 585054008155 Q-loop/lid; other site 585054008156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054008157 ABC transporter signature motif; other site 585054008158 Walker B; other site 585054008159 D-loop; other site 585054008160 H-loop/switch region; other site 585054008161 fructokinase; Reviewed; Region: PRK09557 585054008162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054008163 nucleotide binding site [chemical binding]; other site 585054008164 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 585054008165 hypothetical protein; Provisional; Region: PRK10579 585054008166 hypothetical protein; Provisional; Region: PRK10481 585054008167 hypothetical protein; Provisional; Region: PRK10380 585054008168 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 585054008169 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585054008170 ADP binding site [chemical binding]; other site 585054008171 magnesium binding site [ion binding]; other site 585054008172 putative shikimate binding site; other site 585054008173 hypothetical protein; Validated; Region: PRK00124 585054008174 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 585054008175 pyrroline-5-carboxylate reductase; Region: PLN02688 585054008176 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 585054008177 MASE2 domain; Region: MASE2; pfam05230 585054008178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054008179 metal binding site [ion binding]; metal-binding site 585054008180 active site 585054008181 I-site; other site 585054008182 hypothetical protein; Provisional; Region: PRK11505 585054008183 psiF repeat; Region: PsiF_repeat; pfam07769 585054008184 psiF repeat; Region: PsiF_repeat; pfam07769 585054008185 alkaline phosphatase; Provisional; Region: PRK10518 585054008186 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 585054008187 dimer interface [polypeptide binding]; other site 585054008188 active site 585054008189 anti-RssB factor; Provisional; Region: PRK10244 585054008190 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 585054008191 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585054008192 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585054008193 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 585054008194 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 585054008195 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 585054008196 microcin B17 transporter; Reviewed; Region: PRK11098 585054008197 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 585054008198 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585054008199 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 585054008200 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 585054008201 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585054008202 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585054008203 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 585054008204 dimer interface [polypeptide binding]; other site 585054008205 active site 585054008206 Schiff base residues; other site 585054008207 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 585054008208 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 585054008209 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585054008210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054008211 dimer interface [polypeptide binding]; other site 585054008212 conserved gate region; other site 585054008213 ABC-ATPase subunit interface; other site 585054008214 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 585054008215 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585054008216 Walker A/P-loop; other site 585054008217 ATP binding site [chemical binding]; other site 585054008218 Q-loop/lid; other site 585054008219 ABC transporter signature motif; other site 585054008220 Walker B; other site 585054008221 D-loop; other site 585054008222 H-loop/switch region; other site 585054008223 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 585054008224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054008225 substrate binding pocket [chemical binding]; other site 585054008226 membrane-bound complex binding site; other site 585054008227 hinge residues; other site 585054008228 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 585054008229 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 585054008230 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585054008231 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585054008232 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585054008233 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585054008234 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 585054008235 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 585054008236 acyl-activating enzyme (AAE) consensus motif; other site 585054008237 putative AMP binding site [chemical binding]; other site 585054008238 putative active site [active] 585054008239 putative CoA binding site [chemical binding]; other site 585054008240 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 585054008241 2-methylcitrate dehydratase; Region: prpD; TIGR02330 585054008242 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585054008243 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 585054008244 dimer interface [polypeptide binding]; other site 585054008245 active site 585054008246 citrylCoA binding site [chemical binding]; other site 585054008247 oxalacetate/citrate binding site [chemical binding]; other site 585054008248 coenzyme A binding site [chemical binding]; other site 585054008249 catalytic triad [active] 585054008250 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585054008251 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 585054008252 tetramer interface [polypeptide binding]; other site 585054008253 active site 585054008254 Mg2+/Mn2+ binding site [ion binding]; other site 585054008255 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 585054008256 Propionate catabolism activator; Region: PrpR_N; pfam06506 585054008257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054008258 Walker A motif; other site 585054008259 ATP binding site [chemical binding]; other site 585054008260 Walker B motif; other site 585054008261 arginine finger; other site 585054008262 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054008263 hypothetical protein; Provisional; Region: PRK09929 585054008264 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 585054008265 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 585054008266 heme-binding site [chemical binding]; other site 585054008267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585054008268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054008269 metal binding site [ion binding]; metal-binding site 585054008270 active site 585054008271 I-site; other site 585054008272 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585054008273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054008274 DNA-binding site [nucleotide binding]; DNA binding site 585054008275 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054008276 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585054008277 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585054008278 putative NAD(P) binding site [chemical binding]; other site 585054008279 catalytic Zn binding site [ion binding]; other site 585054008280 structural Zn binding site [ion binding]; other site 585054008281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054008282 D-galactonate transporter; Region: 2A0114; TIGR00893 585054008283 putative substrate translocation pore; other site 585054008284 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585054008285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054008286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054008287 DNA binding residues [nucleotide binding] 585054008288 dimerization interface [polypeptide binding]; other site 585054008289 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054008290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585054008291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054008292 Coenzyme A binding pocket [chemical binding]; other site 585054008293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054008294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054008295 active site 585054008296 catalytic tetrad [active] 585054008297 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054008298 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054008299 active site 585054008300 catalytic tetrad [active] 585054008301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054008302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054008303 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585054008304 putative effector binding pocket; other site 585054008305 putative dimerization interface [polypeptide binding]; other site 585054008306 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585054008307 DNA binding site [nucleotide binding] 585054008308 active site 585054008309 Int/Topo IB signature motif; other site 585054008310 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585054008311 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 585054008312 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585054008313 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585054008314 Phage Tail Collar Domain; Region: Collar; pfam07484 585054008315 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 585054008316 Baseplate J-like protein; Region: Baseplate_J; cl01294 585054008317 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 585054008318 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 585054008319 Phage Tail Protein X; Region: Phage_tail_X; cl02088 585054008320 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 585054008321 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 585054008322 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585054008323 Phage tail tube protein FII; Region: Phage_tube; cl01390 585054008324 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 585054008325 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585054008326 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 585054008327 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 585054008328 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585054008329 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585054008330 oligomer interface [polypeptide binding]; other site 585054008331 active site residues [active] 585054008332 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585054008333 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585054008334 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585054008335 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585054008336 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585054008337 Bor protein; Region: Lambda_Bor; pfam06291 585054008338 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585054008339 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585054008340 catalytic residues [active] 585054008341 Lysis protein S; Region: Lysis_S; pfam04971 585054008342 transcriptional regulator YdeO; Provisional; Region: PRK09940 585054008343 Pleckstrin homology-like domain; Region: PH-like; cl17171 585054008344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054008345 Protein of unknown function (DUF523); Region: DUF523; pfam04463 585054008346 Uncharacterized conserved protein [Function unknown]; Region: COG3272 585054008347 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 585054008348 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 585054008349 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 585054008350 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585054008351 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 585054008352 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 585054008353 prophage protein NinE; Provisional; Region: PRK09689 585054008354 hypothetical protein; Provisional; Region: PRK09741 585054008355 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585054008356 Replication protein P; Region: Phage_lambda_P; pfam06992 585054008357 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 585054008358 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585054008359 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 585054008360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054008361 non-specific DNA binding site [nucleotide binding]; other site 585054008362 Predicted transcriptional regulator [Transcription]; Region: COG2932 585054008363 salt bridge; other site 585054008364 sequence-specific DNA binding site [nucleotide binding]; other site 585054008365 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054008366 Catalytic site [active] 585054008367 Domain of unknown function (DUF955); Region: DUF955; cl01076 585054008368 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 585054008369 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 585054008370 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 585054008371 phage recombination protein Bet; Region: bet_lambda; TIGR01913 585054008372 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 585054008373 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 585054008374 DksA-like zinc finger domain containing protein; Region: PHA00080 585054008375 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585054008376 Helix-turn-helix domain; Region: HTH_17; pfam12728 585054008377 integrase; Provisional; Region: int; PHA02601 585054008378 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 585054008379 Int/Topo IB signature motif; other site 585054008380 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 585054008381 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 585054008382 putative catalytic cysteine [active] 585054008383 gamma-glutamyl kinase; Provisional; Region: PRK05429 585054008384 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 585054008385 nucleotide binding site [chemical binding]; other site 585054008386 homotetrameric interface [polypeptide binding]; other site 585054008387 putative phosphate binding site [ion binding]; other site 585054008388 putative allosteric binding site; other site 585054008389 PUA domain; Region: PUA; pfam01472 585054008390 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585054008391 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585054008392 trimer interface [polypeptide binding]; other site 585054008393 eyelet of channel; other site 585054008394 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 585054008395 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 585054008396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054008397 active site 585054008398 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 585054008399 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 585054008400 metal binding site [ion binding]; metal-binding site 585054008401 dimer interface [polypeptide binding]; other site 585054008402 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 585054008403 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585054008404 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 585054008405 hypothetical protein; Reviewed; Region: PRK09588 585054008406 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 585054008407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585054008408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054008409 Coenzyme A binding pocket [chemical binding]; other site 585054008410 putative toxin YafO; Provisional; Region: PRK09885 585054008411 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 585054008412 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 585054008413 active site 585054008414 DNA polymerase IV; Validated; Region: PRK02406 585054008415 DNA binding site [nucleotide binding] 585054008416 hypothetical protein; Validated; Region: PRK06778 585054008417 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585054008418 ligand binding site [chemical binding]; other site 585054008419 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 585054008420 FHIPEP family; Region: FHIPEP; pfam00771 585054008421 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 585054008422 AAA domain; Region: AAA_30; pfam13604 585054008423 Family description; Region: UvrD_C_2; pfam13538 585054008424 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 585054008425 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 585054008426 protease3; Provisional; Region: PRK15101 585054008427 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585054008428 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585054008429 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585054008430 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 585054008431 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 585054008432 hypothetical protein; Provisional; Region: PRK10332 585054008433 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 585054008434 hypothetical protein; Provisional; Region: PRK11521 585054008435 hypothetical protein; Provisional; Region: PRK10557 585054008436 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585054008437 hypothetical protein; Provisional; Region: PRK10506 585054008438 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585054008439 thymidylate synthase; Reviewed; Region: thyA; PRK01827 585054008440 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 585054008441 dimerization interface [polypeptide binding]; other site 585054008442 active site 585054008443 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 585054008444 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 585054008445 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585054008446 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585054008447 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585054008448 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585054008449 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 585054008450 putative active site [active] 585054008451 Ap4A binding site [chemical binding]; other site 585054008452 nudix motif; other site 585054008453 putative metal binding site [ion binding]; other site 585054008454 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 585054008455 putative DNA-binding cleft [nucleotide binding]; other site 585054008456 putative DNA clevage site; other site 585054008457 molecular lever; other site 585054008458 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585054008459 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585054008460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054008461 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054008462 active site 585054008463 catalytic tetrad [active] 585054008464 conserved hypothetical protein; Region: TIGR02231 585054008465 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 585054008466 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 585054008467 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 585054008468 lysophospholipid transporter LplT; Provisional; Region: PRK11195 585054008469 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 585054008470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585054008471 putative acyl-acceptor binding pocket; other site 585054008472 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 585054008473 acyl-activating enzyme (AAE) consensus motif; other site 585054008474 putative AMP binding site [chemical binding]; other site 585054008475 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 585054008476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054008477 DNA binding site [nucleotide binding] 585054008478 domain linker motif; other site 585054008479 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585054008480 dimerization interface (closed form) [polypeptide binding]; other site 585054008481 ligand binding site [chemical binding]; other site 585054008482 diaminopimelate decarboxylase; Provisional; Region: PRK11165 585054008483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 585054008484 active site 585054008485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054008486 substrate binding site [chemical binding]; other site 585054008487 catalytic residues [active] 585054008488 dimer interface [polypeptide binding]; other site 585054008489 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 585054008490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054008491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054008492 dimerization interface [polypeptide binding]; other site 585054008493 putative acyltransferase; Provisional; Region: PRK05790 585054008494 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585054008495 dimer interface [polypeptide binding]; other site 585054008496 active site 585054008497 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585054008498 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 585054008499 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 585054008500 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 585054008501 DNA binding site [nucleotide binding] 585054008502 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 585054008503 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 585054008504 active site 585054008505 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585054008506 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 585054008507 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 585054008508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585054008509 TPR motif; other site 585054008510 binding surface 585054008511 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 585054008512 hypothetical protein; Provisional; Region: PRK09936 585054008513 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 585054008514 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585054008515 Na binding site [ion binding]; other site 585054008516 putative substrate binding site [chemical binding]; other site 585054008517 cytosine deaminase; Provisional; Region: PRK09230 585054008518 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585054008519 active site 585054008520 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 585054008521 active site 585054008522 metal binding site [ion binding]; metal-binding site 585054008523 Salmonella outer protein D; Region: SopD; cl14701 585054008524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585054008525 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 585054008526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585054008527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585054008528 PerC transcriptional activator; Region: PerC; pfam06069 585054008529 Transposase; Region: HTH_Tnp_1; cl17663 585054008530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585054008531 putative transposase OrfB; Reviewed; Region: PHA02517 585054008532 HTH-like domain; Region: HTH_21; pfam13276 585054008533 Integrase core domain; Region: rve; pfam00665 585054008534 Integrase core domain; Region: rve_2; pfam13333 585054008535 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585054008536 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585054008537 Bacterial SH3 domain; Region: SH3_4; pfam06347 585054008538 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 585054008539 GIY-YIG motif/motif A; other site 585054008540 putative active site [active] 585054008541 putative metal binding site [ion binding]; other site 585054008542 putative transposase OrfB; Reviewed; Region: PHA02517 585054008543 HTH-like domain; Region: HTH_21; pfam13276 585054008544 Integrase core domain; Region: rve; pfam00665 585054008545 Integrase core domain; Region: rve_3; pfam13683 585054008546 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of transposase ORF A, IS3 family (partial) 585054008547 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585054008548 MarR family; Region: MarR_2; pfam12802 585054008549 Evidence 7 : Gene remnant; Product type r : regulator; fragment of Arsenical resistance operon trans-acting repressor (partial) 585054008550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054008551 dimerization interface [polypeptide binding]; other site 585054008552 putative DNA binding site [nucleotide binding]; other site 585054008553 putative Zn2+ binding site [ion binding]; other site 585054008554 AAA ATPase domain; Region: AAA_15; pfam13175 585054008555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054008556 Walker A/P-loop; other site 585054008557 ATP binding site [chemical binding]; other site 585054008558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054008559 Walker B; other site 585054008560 D-loop; other site 585054008561 H-loop/switch region; other site 585054008562 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585054008563 putative active site [active] 585054008564 putative metal-binding site [ion binding]; other site 585054008565 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 585054008566 Part of AAA domain; Region: AAA_19; pfam13245 585054008567 integrase; Provisional; Region: PRK09692 585054008568 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585054008569 active site 585054008570 Int/Topo IB signature motif; other site 585054008571 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585054008572 Peptidase family M23; Region: Peptidase_M23; pfam01551 585054008573 hypothetical protein; Provisional; Region: PRK07490 585054008574 intersubunit interface [polypeptide binding]; other site 585054008575 active site 585054008576 Zn2+ binding site [ion binding]; other site 585054008577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054008578 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 585054008579 substrate binding pocket [chemical binding]; other site 585054008580 membrane-bound complex binding site; other site 585054008581 hinge residues; other site 585054008582 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 585054008583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054008584 dimer interface [polypeptide binding]; other site 585054008585 conserved gate region; other site 585054008586 putative PBP binding loops; other site 585054008587 ABC-ATPase subunit interface; other site 585054008588 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585054008589 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585054008590 Walker A/P-loop; other site 585054008591 ATP binding site [chemical binding]; other site 585054008592 Q-loop/lid; other site 585054008593 ABC transporter signature motif; other site 585054008594 Walker B; other site 585054008595 D-loop; other site 585054008596 H-loop/switch region; other site 585054008597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054008598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054008599 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 585054008600 putative substrate binding pocket [chemical binding]; other site 585054008601 dimerization interface [polypeptide binding]; other site 585054008602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054008603 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 585054008604 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585054008605 homotrimer interaction site [polypeptide binding]; other site 585054008606 putative active site [active] 585054008607 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 585054008608 acetylornithine deacetylase; Provisional; Region: PRK07522 585054008609 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 585054008610 metal binding site [ion binding]; metal-binding site 585054008611 putative dimer interface [polypeptide binding]; other site 585054008612 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585054008613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054008614 catalytic residue [active] 585054008615 glutaminase; Reviewed; Region: PRK12356 585054008616 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585054008617 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 585054008618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585054008619 catalytic loop [active] 585054008620 iron binding site [ion binding]; other site 585054008621 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585054008622 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 585054008623 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 585054008624 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 585054008625 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585054008626 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585054008627 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585054008628 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585054008629 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585054008630 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 585054008631 metal-binding site 585054008632 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 585054008633 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 585054008634 active site 585054008635 metal binding site [ion binding]; metal-binding site 585054008636 nudix motif; other site 585054008637 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 585054008638 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585054008639 dimer interface [polypeptide binding]; other site 585054008640 putative anticodon binding site; other site 585054008641 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585054008642 motif 1; other site 585054008643 active site 585054008644 motif 2; other site 585054008645 motif 3; other site 585054008646 peptide chain release factor 2; Validated; Region: prfB; PRK00578 585054008647 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585054008648 RF-1 domain; Region: RF-1; pfam00472 585054008649 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 585054008650 DHH family; Region: DHH; pfam01368 585054008651 DHHA1 domain; Region: DHHA1; pfam02272 585054008652 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 585054008653 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585054008654 dimerization domain [polypeptide binding]; other site 585054008655 dimer interface [polypeptide binding]; other site 585054008656 catalytic residues [active] 585054008657 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 585054008658 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 585054008659 active site 585054008660 Int/Topo IB signature motif; other site 585054008661 flavodoxin FldB; Provisional; Region: PRK12359 585054008662 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 585054008663 hypothetical protein; Provisional; Region: PRK10878 585054008664 putative global regulator; Reviewed; Region: PRK09559 585054008665 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 585054008666 hemolysin; Provisional; Region: PRK15087 585054008667 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 585054008668 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 585054008669 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 585054008670 beta-galactosidase; Region: BGL; TIGR03356 585054008671 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 585054008672 glycine dehydrogenase; Provisional; Region: PRK05367 585054008673 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585054008674 tetramer interface [polypeptide binding]; other site 585054008675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054008676 catalytic residue [active] 585054008677 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585054008678 tetramer interface [polypeptide binding]; other site 585054008679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054008680 catalytic residue [active] 585054008681 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 585054008682 lipoyl attachment site [posttranslational modification]; other site 585054008683 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 585054008684 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 585054008685 oxidoreductase; Provisional; Region: PRK08013 585054008686 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585054008687 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 585054008688 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585054008689 proline aminopeptidase P II; Provisional; Region: PRK10879 585054008690 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 585054008691 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585054008692 active site 585054008693 hypothetical protein; Reviewed; Region: PRK01736 585054008694 Z-ring-associated protein; Provisional; Region: PRK10972 585054008695 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 585054008696 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 585054008697 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 585054008698 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 585054008699 ligand binding site [chemical binding]; other site 585054008700 NAD binding site [chemical binding]; other site 585054008701 tetramer interface [polypeptide binding]; other site 585054008702 catalytic site [active] 585054008703 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 585054008704 L-serine binding site [chemical binding]; other site 585054008705 ACT domain interface; other site 585054008706 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 585054008707 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585054008708 active site 585054008709 dimer interface [polypeptide binding]; other site 585054008710 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 585054008711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054008712 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 585054008713 putative dimerization interface [polypeptide binding]; other site 585054008714 Uncharacterized conserved protein [Function unknown]; Region: COG2968 585054008715 oxidative stress defense protein; Provisional; Region: PRK11087 585054008716 arginine exporter protein; Provisional; Region: PRK09304 585054008717 mechanosensitive channel MscS; Provisional; Region: PRK10334 585054008718 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585054008719 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585054008720 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 585054008721 active site 585054008722 intersubunit interface [polypeptide binding]; other site 585054008723 zinc binding site [ion binding]; other site 585054008724 Na+ binding site [ion binding]; other site 585054008725 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 585054008726 Phosphoglycerate kinase; Region: PGK; pfam00162 585054008727 substrate binding site [chemical binding]; other site 585054008728 hinge regions; other site 585054008729 ADP binding site [chemical binding]; other site 585054008730 catalytic site [active] 585054008731 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 585054008732 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585054008733 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585054008734 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 585054008735 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585054008736 active site 585054008737 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 585054008738 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585054008739 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585054008740 putative active site [active] 585054008741 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585054008742 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585054008743 putative NAD(P) binding site [chemical binding]; other site 585054008744 catalytic Zn binding site [ion binding]; other site 585054008745 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 585054008746 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585054008747 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585054008748 active site 585054008749 P-loop; other site 585054008750 phosphorylation site [posttranslational modification] 585054008751 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054008752 active site 585054008753 phosphorylation site [posttranslational modification] 585054008754 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585054008755 SPFH domain / Band 7 family; Region: Band_7; pfam01145 585054008756 transketolase; Reviewed; Region: PRK12753 585054008757 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585054008758 TPP-binding site [chemical binding]; other site 585054008759 dimer interface [polypeptide binding]; other site 585054008760 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585054008761 PYR/PP interface [polypeptide binding]; other site 585054008762 dimer interface [polypeptide binding]; other site 585054008763 TPP binding site [chemical binding]; other site 585054008764 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585054008765 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585054008766 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585054008767 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 585054008768 agmatinase; Region: agmatinase; TIGR01230 585054008769 oligomer interface [polypeptide binding]; other site 585054008770 putative active site [active] 585054008771 Mn binding site [ion binding]; other site 585054008772 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 585054008773 metal binding site [ion binding]; metal-binding site 585054008774 substrate binding pocket [chemical binding]; other site 585054008775 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of IS1 transposase InsAB' (part 2) 585054008776 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of IS1 transposase InsAB' (part 1) 585054008777 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585054008778 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585054008779 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585054008780 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585054008781 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585054008782 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 585054008783 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 585054008784 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 585054008785 dimer interface [polypeptide binding]; other site 585054008786 active site 585054008787 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054008788 catalytic residues [active] 585054008789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 585054008790 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 585054008791 S-adenosylmethionine synthetase; Validated; Region: PRK05250 585054008792 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 585054008793 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 585054008794 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 585054008795 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585054008796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054008797 putative substrate translocation pore; other site 585054008798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054008799 hypothetical protein; Provisional; Region: PRK04860 585054008800 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 585054008801 DNA-specific endonuclease I; Provisional; Region: PRK15137 585054008802 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 585054008803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 585054008804 RNA methyltransferase, RsmE family; Region: TIGR00046 585054008805 glutathione synthetase; Provisional; Region: PRK05246 585054008806 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 585054008807 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 585054008808 hypothetical protein; Validated; Region: PRK00228 585054008809 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 585054008810 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 585054008811 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 585054008812 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 585054008813 Walker A motif; other site 585054008814 ATP-binding site [chemical binding]; other site 585054008815 ATP binding site [chemical binding]; other site 585054008816 Walker B motif; other site 585054008817 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 585054008818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054008819 catalytic residue [active] 585054008820 YGGT family; Region: YGGT; pfam02325 585054008821 YGGT family; Region: YGGT; pfam02325 585054008822 hypothetical protein; Validated; Region: PRK05090 585054008823 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 585054008824 active site 585054008825 dimerization interface [polypeptide binding]; other site 585054008826 HemN family oxidoreductase; Provisional; Region: PRK05660 585054008827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054008828 FeS/SAM binding site; other site 585054008829 HemN C-terminal domain; Region: HemN_C; pfam06969 585054008830 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585054008831 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585054008832 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585054008833 DctM-like transporters; Region: DctM; pfam06808 585054008834 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 585054008835 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 585054008836 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 585054008837 homodimer interface [polypeptide binding]; other site 585054008838 active site 585054008839 hypothetical protein; Provisional; Region: PRK10626 585054008840 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 585054008841 hypothetical protein; Provisional; Region: PRK11702 585054008842 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 585054008843 adenine DNA glycosylase; Provisional; Region: PRK10880 585054008844 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585054008845 minor groove reading motif; other site 585054008846 helix-hairpin-helix signature motif; other site 585054008847 substrate binding pocket [chemical binding]; other site 585054008848 active site 585054008849 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 585054008850 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 585054008851 DNA binding and oxoG recognition site [nucleotide binding] 585054008852 oxidative damage protection protein; Provisional; Region: PRK05408 585054008853 murein transglycosylase C; Provisional; Region: mltC; PRK11671 585054008854 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 585054008855 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054008856 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054008857 catalytic residue [active] 585054008858 nucleoside transporter; Region: 2A0110; TIGR00889 585054008859 ornithine decarboxylase; Provisional; Region: PRK13578 585054008860 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585054008861 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585054008862 homodimer interface [polypeptide binding]; other site 585054008863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054008864 catalytic residue [active] 585054008865 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585054008866 Protein of unknown function (DUF554); Region: DUF554; pfam04474 585054008867 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 585054008868 Peptidase M60-like family; Region: M60-like; pfam13402 585054008869 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585054008870 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 585054008871 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585054008872 putative type II secretion protein GspC; Provisional; Region: PRK09681 585054008873 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 585054008874 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585054008875 type II secretion system protein D; Region: type_II_gspD; TIGR02517 585054008876 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585054008877 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585054008878 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585054008879 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585054008880 type II secretion system protein E; Region: type_II_gspE; TIGR02533 585054008881 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585054008882 Walker A motif; other site 585054008883 ATP binding site [chemical binding]; other site 585054008884 Walker B motif; other site 585054008885 type II secretion system protein F; Region: GspF; TIGR02120 585054008886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585054008887 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585054008888 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585054008889 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 585054008890 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 585054008891 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 585054008892 Type II transport protein GspH; Region: GspH; pfam12019 585054008893 type II secretion system protein I; Region: gspI; TIGR01707 585054008894 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 585054008895 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585054008896 type II secretion system protein J; Region: gspJ; TIGR01711 585054008897 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 585054008898 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 585054008899 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 585054008900 GspL-like protein; Provisional; Region: PRK09662 585054008901 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 585054008902 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 585054008903 CHAP domain; Region: CHAP; pfam05257 585054008904 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585054008905 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585054008906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054008907 putative S-transferase; Provisional; Region: PRK11752 585054008908 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585054008909 C-terminal domain interface [polypeptide binding]; other site 585054008910 GSH binding site (G-site) [chemical binding]; other site 585054008911 dimer interface [polypeptide binding]; other site 585054008912 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 585054008913 dimer interface [polypeptide binding]; other site 585054008914 N-terminal domain interface [polypeptide binding]; other site 585054008915 active site 585054008916 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 585054008917 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 585054008918 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 585054008919 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 585054008920 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 585054008921 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585054008922 putative substrate-binding site; other site 585054008923 nickel binding site [ion binding]; other site 585054008924 hydrogenase 2 large subunit; Provisional; Region: PRK10467 585054008925 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585054008926 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 585054008927 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 585054008928 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 585054008929 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585054008930 hydrogenase 2 small subunit; Provisional; Region: PRK10468 585054008931 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585054008932 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585054008933 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 585054008934 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585054008935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585054008936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054008937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054008938 active site 585054008939 catalytic tetrad [active] 585054008940 hypothetical protein; Provisional; Region: PRK05208 585054008941 oxidoreductase; Provisional; Region: PRK07985 585054008942 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 585054008943 NAD binding site [chemical binding]; other site 585054008944 metal binding site [ion binding]; metal-binding site 585054008945 active site 585054008946 biopolymer transport protein ExbD; Provisional; Region: PRK11267 585054008947 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585054008948 biopolymer transport protein ExbB; Provisional; Region: PRK10414 585054008949 cystathionine beta-lyase; Provisional; Region: PRK08114 585054008950 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585054008951 homodimer interface [polypeptide binding]; other site 585054008952 substrate-cofactor binding pocket; other site 585054008953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054008954 catalytic residue [active] 585054008955 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585054008956 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585054008957 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 585054008958 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585054008959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054008960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054008961 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 585054008962 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 585054008963 dimer interface [polypeptide binding]; other site 585054008964 active site 585054008965 metal binding site [ion binding]; metal-binding site 585054008966 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585054008967 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585054008968 active site 585054008969 catalytic tetrad [active] 585054008970 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585054008971 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585054008972 transmembrane helices; other site 585054008973 putative outer membrane lipoprotein; Provisional; Region: PRK09973 585054008974 hypothetical protein; Provisional; Region: PRK01254 585054008975 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 585054008976 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 585054008977 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585054008978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054008979 DNA-binding site [nucleotide binding]; DNA binding site 585054008980 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054008981 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585054008982 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054008983 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054008984 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585054008985 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585054008986 putative NAD(P) binding site [chemical binding]; other site 585054008987 catalytic Zn binding site [ion binding]; other site 585054008988 structural Zn binding site [ion binding]; other site 585054008989 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 585054008990 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585054008991 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 585054008992 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585054008993 DctM-like transporters; Region: DctM; pfam06808 585054008994 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 585054008995 FtsI repressor; Provisional; Region: PRK10883 585054008996 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585054008997 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585054008998 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 585054008999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585054009000 putative acyl-acceptor binding pocket; other site 585054009001 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 585054009002 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585054009003 CAP-like domain; other site 585054009004 active site 585054009005 primary dimer interface [polypeptide binding]; other site 585054009006 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585054009007 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 585054009008 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 585054009009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054009010 active site 585054009011 phosphorylation site [posttranslational modification] 585054009012 intermolecular recognition site; other site 585054009013 dimerization interface [polypeptide binding]; other site 585054009014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054009015 DNA binding site [nucleotide binding] 585054009016 sensor protein QseC; Provisional; Region: PRK10337 585054009017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054009018 dimer interface [polypeptide binding]; other site 585054009019 phosphorylation site [posttranslational modification] 585054009020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054009021 ATP binding site [chemical binding]; other site 585054009022 Mg2+ binding site [ion binding]; other site 585054009023 G-X-G motif; other site 585054009024 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 585054009025 Uncharacterized conserved protein [Function unknown]; Region: COG1359 585054009026 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 585054009027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054009028 ATP binding site [chemical binding]; other site 585054009029 Mg2+ binding site [ion binding]; other site 585054009030 G-X-G motif; other site 585054009031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585054009032 anchoring element; other site 585054009033 dimer interface [polypeptide binding]; other site 585054009034 ATP binding site [chemical binding]; other site 585054009035 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585054009036 active site 585054009037 metal binding site [ion binding]; metal-binding site 585054009038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585054009039 esterase YqiA; Provisional; Region: PRK11071 585054009040 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585054009041 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 585054009042 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585054009043 active site 585054009044 metal binding site [ion binding]; metal-binding site 585054009045 hexamer interface [polypeptide binding]; other site 585054009046 putative dehydrogenase; Provisional; Region: PRK11039 585054009047 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 585054009048 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585054009049 dimer interface [polypeptide binding]; other site 585054009050 ADP-ribose binding site [chemical binding]; other site 585054009051 active site 585054009052 nudix motif; other site 585054009053 metal binding site [ion binding]; metal-binding site 585054009054 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 585054009055 hypothetical protein; Provisional; Region: PRK11653 585054009056 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585054009057 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 585054009058 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585054009059 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585054009060 catalytic residues [active] 585054009061 hinge region; other site 585054009062 alpha helical domain; other site 585054009063 putative disulfide oxidoreductase; Provisional; Region: PRK04307 585054009064 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 585054009065 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585054009066 putative active site [active] 585054009067 metal binding site [ion binding]; metal-binding site 585054009068 zinc transporter ZupT; Provisional; Region: PRK04201 585054009069 ZIP Zinc transporter; Region: Zip; pfam02535 585054009070 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 585054009071 putative fimbrial protein; Provisional; Region: PRK09733 585054009072 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585054009073 PapC N-terminal domain; Region: PapC_N; pfam13954 585054009074 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054009075 PapC C-terminal domain; Region: PapC_C; pfam13953 585054009076 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585054009077 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054009078 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054009079 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 585054009080 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 585054009081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 585054009082 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 585054009083 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 585054009084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 585054009085 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 585054009086 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 585054009087 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 585054009088 putative ribose interaction site [chemical binding]; other site 585054009089 putative ADP binding site [chemical binding]; other site 585054009090 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 585054009091 active site 585054009092 nucleotide binding site [chemical binding]; other site 585054009093 HIGH motif; other site 585054009094 KMSKS motif; other site 585054009095 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 585054009096 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585054009097 metal binding triad; other site 585054009098 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585054009099 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585054009100 metal binding triad; other site 585054009101 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585054009102 Uncharacterized conserved protein [Function unknown]; Region: COG3025 585054009103 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 585054009104 putative active site [active] 585054009105 putative metal binding residues [ion binding]; other site 585054009106 signature motif; other site 585054009107 putative triphosphate binding site [ion binding]; other site 585054009108 CHAD domain; Region: CHAD; pfam05235 585054009109 SH3 domain-containing protein; Provisional; Region: PRK10884 585054009110 Bacterial SH3 domain homologues; Region: SH3b; smart00287 585054009111 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 585054009112 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585054009113 active site 585054009114 NTP binding site [chemical binding]; other site 585054009115 metal binding triad [ion binding]; metal-binding site 585054009116 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585054009117 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054009118 Zn2+ binding site [ion binding]; other site 585054009119 Mg2+ binding site [ion binding]; other site 585054009120 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 585054009121 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585054009122 homooctamer interface [polypeptide binding]; other site 585054009123 active site 585054009124 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 585054009125 UGMP family protein; Validated; Region: PRK09604 585054009126 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 585054009127 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 585054009128 DNA primase; Validated; Region: dnaG; PRK05667 585054009129 CHC2 zinc finger; Region: zf-CHC2; pfam01807 585054009130 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 585054009131 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 585054009132 active site 585054009133 metal binding site [ion binding]; metal-binding site 585054009134 interdomain interaction site; other site 585054009135 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 585054009136 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 585054009137 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 585054009138 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 585054009139 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585054009140 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 585054009141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585054009142 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585054009143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585054009144 DNA binding residues [nucleotide binding] 585054009145 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 585054009146 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 585054009147 active site 585054009148 SUMO-1 interface [polypeptide binding]; other site 585054009149 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 585054009150 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 585054009151 putative GEF interaction site [polypeptide binding]; other site 585054009152 G1 box; other site 585054009153 GTP/Mg2+ binding site [chemical binding]; other site 585054009154 Switch I region; other site 585054009155 G2 box; other site 585054009156 G3 box; other site 585054009157 Switch II region; other site 585054009158 G4 box; other site 585054009159 G5 box; other site 585054009160 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 585054009161 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 585054009162 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 585054009163 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355 585054009164 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 585054009165 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 585054009166 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 585054009167 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 585054009168 active site 585054009169 putative glycine/sarcosine/betaine reductase complex protein A; Provisional; Region: PRK14717 585054009170 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 585054009171 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585054009172 catalytic residues [active] 585054009173 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 585054009174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054009175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054009176 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 585054009177 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 585054009178 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 585054009179 FAD binding pocket [chemical binding]; other site 585054009180 FAD binding motif [chemical binding]; other site 585054009181 phosphate binding motif [ion binding]; other site 585054009182 NAD binding pocket [chemical binding]; other site 585054009183 Predicted transcriptional regulators [Transcription]; Region: COG1695 585054009184 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 585054009185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054009186 PAS domain; Region: PAS_9; pfam13426 585054009187 putative active site [active] 585054009188 heme pocket [chemical binding]; other site 585054009189 HAMP domain; Region: HAMP; pfam00672 585054009190 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 585054009191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585054009192 dimer interface [polypeptide binding]; other site 585054009193 putative CheW interface [polypeptide binding]; other site 585054009194 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 585054009195 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585054009196 inhibitor-cofactor binding pocket; inhibition site 585054009197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054009198 catalytic residue [active] 585054009199 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 585054009200 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585054009201 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585054009202 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 585054009203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054009204 DNA-binding site [nucleotide binding]; DNA binding site 585054009205 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054009206 D-mannonate oxidoreductase; Provisional; Region: PRK15037 585054009207 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054009208 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054009209 mannonate dehydratase; Region: uxuA; TIGR00695 585054009210 mannonate dehydratase; Provisional; Region: PRK03906 585054009211 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 585054009212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585054009213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054009214 DNA binding residues [nucleotide binding] 585054009215 dimerization interface [polypeptide binding]; other site 585054009216 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 585054009217 MgtC family; Region: MgtC; pfam02308 585054009218 acid-resistance protein; Provisional; Region: hdeB; PRK11566 585054009219 acid-resistance protein; Provisional; Region: PRK10208 585054009220 acid-resistance membrane protein; Provisional; Region: PRK10209 585054009221 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 585054009222 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 585054009223 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054009224 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054009225 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585054009226 Protein export membrane protein; Region: SecD_SecF; cl14618 585054009227 Protein export membrane protein; Region: SecD_SecF; cl14618 585054009228 transcriptional regulator YdeO; Provisional; Region: PRK09940 585054009229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054009230 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 585054009231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054009232 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585054009233 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585054009234 catalytic core [active] 585054009235 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585054009236 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 585054009237 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 585054009238 threonine/serine transporter TdcC; Provisional; Region: PRK13629 585054009239 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585054009240 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585054009241 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585054009242 tetramer interface [polypeptide binding]; other site 585054009243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054009244 catalytic residue [active] 585054009245 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 585054009246 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 585054009247 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 585054009248 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 585054009249 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 585054009250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585054009251 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 585054009252 active site 585054009253 FMN binding site [chemical binding]; other site 585054009254 2,4-decadienoyl-CoA binding site; other site 585054009255 catalytic residue [active] 585054009256 4Fe-4S cluster binding site [ion binding]; other site 585054009257 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 585054009258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054009259 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 585054009260 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585054009261 dimer interface [polypeptide binding]; other site 585054009262 ligand binding site [chemical binding]; other site 585054009263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054009264 dimerization interface [polypeptide binding]; other site 585054009265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585054009266 dimer interface [polypeptide binding]; other site 585054009267 putative CheW interface [polypeptide binding]; other site 585054009268 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 585054009269 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585054009270 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585054009271 putative active site [active] 585054009272 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 585054009273 Na binding site [ion binding]; other site 585054009274 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585054009275 homotrimer interaction site [polypeptide binding]; other site 585054009276 putative active site [active] 585054009277 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 585054009278 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 585054009279 active site 585054009280 putative substrate binding pocket [chemical binding]; other site 585054009281 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 585054009282 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 585054009283 dimer interface [polypeptide binding]; other site 585054009284 active site 585054009285 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054009286 substrate binding site [chemical binding]; other site 585054009287 catalytic residue [active] 585054009288 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 585054009289 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585054009290 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 585054009291 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 585054009292 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 585054009293 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 585054009294 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 585054009295 NAD binding site [chemical binding]; other site 585054009296 catalytic residues [active] 585054009297 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 585054009298 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585054009299 putative active site [active] 585054009300 putative metal binding site [ion binding]; other site 585054009301 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 585054009302 putative substrate binding pocket [chemical binding]; other site 585054009303 trimer interface [polypeptide binding]; other site 585054009304 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 585054009305 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585054009306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054009307 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 585054009308 putative substrate translocation pore; other site 585054009309 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 585054009310 Cupin domain; Region: Cupin_2; pfam07883 585054009311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054009312 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 585054009313 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 585054009314 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 585054009315 carbon starvation protein A; Provisional; Region: PRK15015 585054009316 Carbon starvation protein CstA; Region: CstA; pfam02554 585054009317 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585054009318 Uncharacterized small protein [Function unknown]; Region: COG2879 585054009319 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 585054009320 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 585054009321 P-loop, Walker A motif; other site 585054009322 Base recognition motif; other site 585054009323 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 585054009324 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 585054009325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 585054009326 Fic/DOC family; Region: Fic; cl00960 585054009327 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 585054009328 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 585054009329 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 585054009330 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054009331 ATP binding site [chemical binding]; other site 585054009332 putative Mg++ binding site [ion binding]; other site 585054009333 HsdM N-terminal domain; Region: HsdM_N; pfam12161 585054009334 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 585054009335 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585054009336 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 585054009337 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 585054009338 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 585054009339 endoribonuclease SymE; Provisional; Region: PRK13605 585054009340 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 585054009341 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 585054009342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054009343 Walker A motif; other site 585054009344 ATP binding site [chemical binding]; other site 585054009345 Walker B motif; other site 585054009346 arginine finger; other site 585054009347 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 585054009348 DEAD-like helicases superfamily; Region: DEXDc; smart00487 585054009349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054009350 ATP binding site [chemical binding]; other site 585054009351 putative Mg++ binding site [ion binding]; other site 585054009352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054009353 nucleotide binding region [chemical binding]; other site 585054009354 ATP-binding site [chemical binding]; other site 585054009355 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 585054009356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 585054009357 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 585054009358 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585054009359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054009360 DNA-binding site [nucleotide binding]; DNA binding site 585054009361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054009362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054009363 homodimer interface [polypeptide binding]; other site 585054009364 catalytic residue [active] 585054009365 putative transposase; Provisional; Region: PRK09857 585054009366 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585054009367 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 585054009368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054009369 putative substrate translocation pore; other site 585054009370 Predicted membrane protein [Function unknown]; Region: COG2733 585054009371 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585054009372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585054009373 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585054009374 Protein kinase domain; Region: Pkinase; pfam00069 585054009375 Catalytic domain of Protein Kinases; Region: PKc; cd00180 585054009376 active site 585054009377 ATP binding site [chemical binding]; other site 585054009378 substrate binding site [chemical binding]; other site 585054009379 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585054009380 substrate binding site [chemical binding]; other site 585054009381 activation loop (A-loop); other site 585054009382 activation loop (A-loop); other site 585054009383 HerA helicase [Replication, recombination, and repair]; Region: COG0433 585054009384 Domain of unknown function DUF87; Region: DUF87; pfam01935 585054009385 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 585054009386 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 585054009387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585054009388 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 585054009389 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 585054009390 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 585054009391 HNH endonuclease; Region: HNH_2; pfam13391 585054009392 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of integrase; KpLE2 phage-like element (part 2) 585054009393 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of integrase; KpLE2 phage-like element (part 1) 585054009394 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585054009395 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585054009396 putative NAD(P) binding site [chemical binding]; other site 585054009397 putative substrate binding site [chemical binding]; other site 585054009398 catalytic Zn binding site [ion binding]; other site 585054009399 structural Zn binding site [ion binding]; other site 585054009400 dimer interface [polypeptide binding]; other site 585054009401 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 585054009402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585054009403 Walker A motif; other site 585054009404 ATP binding site [chemical binding]; other site 585054009405 Predicted permease; Region: DUF318; pfam03773 585054009406 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 585054009407 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585054009408 NAD binding site [chemical binding]; other site 585054009409 active site 585054009410 intracellular protease, PfpI family; Region: PfpI; TIGR01382 585054009411 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 585054009412 proposed catalytic triad [active] 585054009413 conserved cys residue [active] 585054009414 hypothetical protein; Provisional; Region: PRK03467 585054009415 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 585054009416 GIY-YIG motif/motif A; other site 585054009417 putative active site [active] 585054009418 putative metal binding site [ion binding]; other site 585054009419 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585054009420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054009421 Coenzyme A binding pocket [chemical binding]; other site 585054009422 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 585054009423 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585054009424 Peptidase family U32; Region: Peptidase_U32; pfam01136 585054009425 putative protease; Provisional; Region: PRK15447 585054009426 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585054009427 hypothetical protein; Provisional; Region: PRK10508 585054009428 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 585054009429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 585054009430 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585054009431 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 585054009432 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 585054009433 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 585054009434 Coenzyme A transferase; Region: CoA_trans; cl17247 585054009435 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 585054009436 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 585054009437 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 585054009438 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 585054009439 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 585054009440 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585054009441 carboxyltransferase (CT) interaction site; other site 585054009442 biotinylation site [posttranslational modification]; other site 585054009443 Malonate transporter MadL subunit; Region: MadL; cl04273 585054009444 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 585054009445 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944 585054009446 hexamer interface [polypeptide binding]; other site 585054009447 RNA binding site [nucleotide binding]; other site 585054009448 Histidine-zinc binding site [chemical binding]; other site 585054009449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054009450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054009451 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 585054009452 putative dimerization interface [polypeptide binding]; other site 585054009453 tryptophan permease; Provisional; Region: PRK10483 585054009454 aromatic amino acid transport protein; Region: araaP; TIGR00837 585054009455 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 585054009456 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585054009457 ATP binding site [chemical binding]; other site 585054009458 Mg++ binding site [ion binding]; other site 585054009459 motif III; other site 585054009460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054009461 nucleotide binding region [chemical binding]; other site 585054009462 ATP-binding site [chemical binding]; other site 585054009463 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 585054009464 putative RNA binding site [nucleotide binding]; other site 585054009465 lipoprotein NlpI; Provisional; Region: PRK11189 585054009466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585054009467 binding surface 585054009468 TPR motif; other site 585054009469 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 585054009470 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 585054009471 RNase E interface [polypeptide binding]; other site 585054009472 trimer interface [polypeptide binding]; other site 585054009473 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 585054009474 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 585054009475 RNase E interface [polypeptide binding]; other site 585054009476 trimer interface [polypeptide binding]; other site 585054009477 active site 585054009478 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 585054009479 putative nucleic acid binding region [nucleotide binding]; other site 585054009480 G-X-X-G motif; other site 585054009481 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 585054009482 RNA binding site [nucleotide binding]; other site 585054009483 domain interface; other site 585054009484 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 585054009485 16S/18S rRNA binding site [nucleotide binding]; other site 585054009486 S13e-L30e interaction site [polypeptide binding]; other site 585054009487 25S rRNA binding site [nucleotide binding]; other site 585054009488 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 585054009489 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 585054009490 RNA binding site [nucleotide binding]; other site 585054009491 active site 585054009492 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 585054009493 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 585054009494 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585054009495 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 585054009496 translation initiation factor IF-2; Region: IF-2; TIGR00487 585054009497 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585054009498 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 585054009499 G1 box; other site 585054009500 putative GEF interaction site [polypeptide binding]; other site 585054009501 GTP/Mg2+ binding site [chemical binding]; other site 585054009502 Switch I region; other site 585054009503 G2 box; other site 585054009504 G3 box; other site 585054009505 Switch II region; other site 585054009506 G4 box; other site 585054009507 G5 box; other site 585054009508 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 585054009509 Translation-initiation factor 2; Region: IF-2; pfam11987 585054009510 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 585054009511 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 585054009512 NusA N-terminal domain; Region: NusA_N; pfam08529 585054009513 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 585054009514 RNA binding site [nucleotide binding]; other site 585054009515 homodimer interface [polypeptide binding]; other site 585054009516 NusA-like KH domain; Region: KH_5; pfam13184 585054009517 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 585054009518 G-X-X-G motif; other site 585054009519 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585054009520 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585054009521 ribosome maturation protein RimP; Reviewed; Region: PRK00092 585054009522 Sm and related proteins; Region: Sm_like; cl00259 585054009523 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 585054009524 putative oligomer interface [polypeptide binding]; other site 585054009525 putative RNA binding site [nucleotide binding]; other site 585054009526 argininosuccinate synthase; Validated; Region: PRK05370 585054009527 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585054009528 Sulfatase; Region: Sulfatase; pfam00884 585054009529 Preprotein translocase SecG subunit; Region: SecG; pfam03840 585054009530 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 585054009531 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 585054009532 active site 585054009533 substrate binding site [chemical binding]; other site 585054009534 metal binding site [ion binding]; metal-binding site 585054009535 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 585054009536 dihydropteroate synthase; Region: DHPS; TIGR01496 585054009537 substrate binding pocket [chemical binding]; other site 585054009538 dimer interface [polypeptide binding]; other site 585054009539 inhibitor binding site; inhibition site 585054009540 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 585054009541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054009542 Walker A motif; other site 585054009543 ATP binding site [chemical binding]; other site 585054009544 Walker B motif; other site 585054009545 arginine finger; other site 585054009546 Peptidase family M41; Region: Peptidase_M41; pfam01434 585054009547 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 585054009548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054009549 S-adenosylmethionine binding site [chemical binding]; other site 585054009550 RNA-binding protein YhbY; Provisional; Region: PRK10343 585054009551 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 585054009552 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585054009553 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585054009554 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 585054009555 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 585054009556 GTPase CgtA; Reviewed; Region: obgE; PRK12298 585054009557 GTP1/OBG; Region: GTP1_OBG; pfam01018 585054009558 Obg GTPase; Region: Obg; cd01898 585054009559 G1 box; other site 585054009560 GTP/Mg2+ binding site [chemical binding]; other site 585054009561 Switch I region; other site 585054009562 G2 box; other site 585054009563 G3 box; other site 585054009564 Switch II region; other site 585054009565 G4 box; other site 585054009566 G5 box; other site 585054009567 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585054009568 EamA-like transporter family; Region: EamA; pfam00892 585054009569 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 585054009570 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 585054009571 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 585054009572 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585054009573 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585054009574 substrate binding pocket [chemical binding]; other site 585054009575 chain length determination region; other site 585054009576 substrate-Mg2+ binding site; other site 585054009577 catalytic residues [active] 585054009578 aspartate-rich region 1; other site 585054009579 active site lid residues [active] 585054009580 aspartate-rich region 2; other site 585054009581 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 585054009582 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 585054009583 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 585054009584 hinge; other site 585054009585 active site 585054009586 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 585054009587 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 585054009588 anti sigma factor interaction site; other site 585054009589 regulatory phosphorylation site [posttranslational modification]; other site 585054009590 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 585054009591 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 585054009592 mce related protein; Region: MCE; pfam02470 585054009593 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 585054009594 conserved hypothetical integral membrane protein; Region: TIGR00056 585054009595 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 585054009596 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 585054009597 Walker A/P-loop; other site 585054009598 ATP binding site [chemical binding]; other site 585054009599 Q-loop/lid; other site 585054009600 ABC transporter signature motif; other site 585054009601 Walker B; other site 585054009602 D-loop; other site 585054009603 H-loop/switch region; other site 585054009604 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 585054009605 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585054009606 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585054009607 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 585054009608 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585054009609 putative active site [active] 585054009610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585054009611 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 585054009612 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 585054009613 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 585054009614 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 585054009615 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 585054009616 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 585054009617 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 585054009618 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 585054009619 Walker A/P-loop; other site 585054009620 ATP binding site [chemical binding]; other site 585054009621 Q-loop/lid; other site 585054009622 ABC transporter signature motif; other site 585054009623 Walker B; other site 585054009624 D-loop; other site 585054009625 H-loop/switch region; other site 585054009626 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 585054009627 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 585054009628 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 585054009629 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 585054009630 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585054009631 30S subunit binding site; other site 585054009632 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054009633 active site 585054009634 phosphorylation site [posttranslational modification] 585054009635 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 585054009636 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585054009637 dimerization domain swap beta strand [polypeptide binding]; other site 585054009638 regulatory protein interface [polypeptide binding]; other site 585054009639 active site 585054009640 regulatory phosphorylation site [posttranslational modification]; other site 585054009641 hypothetical protein; Provisional; Region: PRK10345 585054009642 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 585054009643 Transglycosylase; Region: Transgly; cl17702 585054009644 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 585054009645 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 585054009646 conserved cys residue [active] 585054009647 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 585054009648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054009649 putative active site [active] 585054009650 heme pocket [chemical binding]; other site 585054009651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054009652 dimer interface [polypeptide binding]; other site 585054009653 phosphorylation site [posttranslational modification] 585054009654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054009655 ATP binding site [chemical binding]; other site 585054009656 Mg2+ binding site [ion binding]; other site 585054009657 G-X-G motif; other site 585054009658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054009659 active site 585054009660 phosphorylation site [posttranslational modification] 585054009661 intermolecular recognition site; other site 585054009662 dimerization interface [polypeptide binding]; other site 585054009663 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585054009664 putative binding surface; other site 585054009665 active site 585054009666 radical SAM protein, TIGR01212 family; Region: TIGR01212 585054009667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054009668 FeS/SAM binding site; other site 585054009669 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 585054009670 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 585054009671 active site 585054009672 dimer interface [polypeptide binding]; other site 585054009673 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 585054009674 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 585054009675 active site 585054009676 FMN binding site [chemical binding]; other site 585054009677 substrate binding site [chemical binding]; other site 585054009678 3Fe-4S cluster binding site [ion binding]; other site 585054009679 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 585054009680 domain interface; other site 585054009681 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 585054009682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054009683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054009684 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 585054009685 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 585054009686 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585054009687 N-acetylmannosamine kinase; Provisional; Region: PRK05082 585054009688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054009689 nucleotide binding site [chemical binding]; other site 585054009690 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585054009691 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 585054009692 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 585054009693 putative active site cavity [active] 585054009694 putative sialic acid transporter; Provisional; Region: PRK03893 585054009695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054009696 putative substrate translocation pore; other site 585054009697 N-acetylneuraminate lyase; Region: nanA; TIGR00683 585054009698 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 585054009699 inhibitor site; inhibition site 585054009700 active site 585054009701 dimer interface [polypeptide binding]; other site 585054009702 catalytic residue [active] 585054009703 transcriptional regulator NanR; Provisional; Region: PRK03837 585054009704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054009705 DNA-binding site [nucleotide binding]; DNA binding site 585054009706 FCD domain; Region: FCD; pfam07729 585054009707 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 585054009708 stringent starvation protein A; Provisional; Region: sspA; PRK09481 585054009709 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 585054009710 C-terminal domain interface [polypeptide binding]; other site 585054009711 putative GSH binding site (G-site) [chemical binding]; other site 585054009712 dimer interface [polypeptide binding]; other site 585054009713 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 585054009714 dimer interface [polypeptide binding]; other site 585054009715 N-terminal domain interface [polypeptide binding]; other site 585054009716 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 585054009717 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 585054009718 23S rRNA interface [nucleotide binding]; other site 585054009719 L3 interface [polypeptide binding]; other site 585054009720 Predicted ATPase [General function prediction only]; Region: COG1485 585054009721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 585054009722 hypothetical protein; Provisional; Region: PRK11677 585054009723 serine endoprotease; Provisional; Region: PRK10139 585054009724 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585054009725 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585054009726 protein binding site [polypeptide binding]; other site 585054009727 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585054009728 serine endoprotease; Provisional; Region: PRK10898 585054009729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585054009730 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585054009731 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 585054009732 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 585054009733 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 585054009734 Citrate transporter; Region: CitMHS; pfam03600 585054009735 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585054009736 transmembrane helices; other site 585054009737 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585054009738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054009739 DNA-binding site [nucleotide binding]; DNA binding site 585054009740 FCD domain; Region: FCD; pfam07729 585054009741 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585054009742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054009743 DNA-binding site [nucleotide binding]; DNA binding site 585054009744 malate dehydrogenase; Provisional; Region: PRK05086 585054009745 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 585054009746 NAD binding site [chemical binding]; other site 585054009747 dimerization interface [polypeptide binding]; other site 585054009748 Substrate binding site [chemical binding]; other site 585054009749 arginine repressor; Provisional; Region: PRK05066 585054009750 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 585054009751 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 585054009752 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585054009753 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 585054009754 RNAase interaction site [polypeptide binding]; other site 585054009755 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 585054009756 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585054009757 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 585054009758 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054009759 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054009760 efflux system membrane protein; Provisional; Region: PRK11594 585054009761 transcriptional regulator; Provisional; Region: PRK10632 585054009762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054009763 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 585054009764 putative effector binding pocket; other site 585054009765 dimerization interface [polypeptide binding]; other site 585054009766 protease TldD; Provisional; Region: tldD; PRK10735 585054009767 hypothetical protein; Provisional; Region: PRK10899 585054009768 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585054009769 ribonuclease G; Provisional; Region: PRK11712 585054009770 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585054009771 homodimer interface [polypeptide binding]; other site 585054009772 oligonucleotide binding site [chemical binding]; other site 585054009773 Maf-like protein; Region: Maf; pfam02545 585054009774 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585054009775 active site 585054009776 dimer interface [polypeptide binding]; other site 585054009777 rod shape-determining protein MreD; Provisional; Region: PRK11060 585054009778 rod shape-determining protein MreC; Region: mreC; TIGR00219 585054009779 rod shape-determining protein MreC; Region: MreC; pfam04085 585054009780 rod shape-determining protein MreB; Provisional; Region: PRK13927 585054009781 MreB and similar proteins; Region: MreB_like; cd10225 585054009782 nucleotide binding site [chemical binding]; other site 585054009783 Mg binding site [ion binding]; other site 585054009784 putative protofilament interaction site [polypeptide binding]; other site 585054009785 RodZ interaction site [polypeptide binding]; other site 585054009786 regulatory protein CsrD; Provisional; Region: PRK11059 585054009787 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054009788 metal binding site [ion binding]; metal-binding site 585054009789 active site 585054009790 I-site; other site 585054009791 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054009792 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 585054009793 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 585054009794 NADP binding site [chemical binding]; other site 585054009795 dimer interface [polypeptide binding]; other site 585054009796 TMAO/DMSO reductase; Reviewed; Region: PRK05363 585054009797 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 585054009798 Moco binding site; other site 585054009799 metal coordination site [ion binding]; other site 585054009800 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 585054009801 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 585054009802 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585054009803 carboxyltransferase (CT) interaction site; other site 585054009804 biotinylation site [posttranslational modification]; other site 585054009805 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 585054009806 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585054009807 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585054009808 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 585054009809 hypothetical protein; Provisional; Region: PRK10633 585054009810 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 585054009811 Na binding site [ion binding]; other site 585054009812 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 585054009813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585054009814 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 585054009815 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585054009816 FMN binding site [chemical binding]; other site 585054009817 active site 585054009818 catalytic residues [active] 585054009819 substrate binding site [chemical binding]; other site 585054009820 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 585054009821 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 585054009822 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585054009823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054009824 DNA methylase; Region: N6_N4_Mtase; pfam01555 585054009825 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 585054009826 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 585054009827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054009828 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585054009829 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585054009830 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054009831 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054009832 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585054009833 Protein export membrane protein; Region: SecD_SecF; cl14618 585054009834 Protein export membrane protein; Region: SecD_SecF; cl14618 585054009835 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585054009836 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585054009837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054009838 substrate binding pocket [chemical binding]; other site 585054009839 membrane-bound complex binding site; other site 585054009840 hinge residues; other site 585054009841 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 585054009842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054009843 conserved gate region; other site 585054009844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054009845 dimer interface [polypeptide binding]; other site 585054009846 conserved gate region; other site 585054009847 putative PBP binding loops; other site 585054009848 ABC-ATPase subunit interface; other site 585054009849 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585054009850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054009851 dimer interface [polypeptide binding]; other site 585054009852 conserved gate region; other site 585054009853 putative PBP binding loops; other site 585054009854 ABC-ATPase subunit interface; other site 585054009855 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585054009856 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585054009857 Walker A/P-loop; other site 585054009858 ATP binding site [chemical binding]; other site 585054009859 Q-loop/lid; other site 585054009860 ABC transporter signature motif; other site 585054009861 Walker B; other site 585054009862 D-loop; other site 585054009863 H-loop/switch region; other site 585054009864 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 585054009865 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 585054009866 trimer interface [polypeptide binding]; other site 585054009867 putative metal binding site [ion binding]; other site 585054009868 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 585054009869 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585054009870 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585054009871 shikimate binding site; other site 585054009872 NAD(P) binding site [chemical binding]; other site 585054009873 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 585054009874 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585054009875 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 585054009876 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585054009877 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585054009878 hypothetical protein; Validated; Region: PRK03430 585054009879 hypothetical protein; Provisional; Region: PRK10736 585054009880 DNA protecting protein DprA; Region: dprA; TIGR00732 585054009881 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 585054009882 active site 585054009883 catalytic residues [active] 585054009884 metal binding site [ion binding]; metal-binding site 585054009885 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 585054009886 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 585054009887 putative active site [active] 585054009888 substrate binding site [chemical binding]; other site 585054009889 putative cosubstrate binding site; other site 585054009890 catalytic site [active] 585054009891 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 585054009892 substrate binding site [chemical binding]; other site 585054009893 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 585054009894 putative RNA binding site [nucleotide binding]; other site 585054009895 16S rRNA methyltransferase B; Provisional; Region: PRK10901 585054009896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054009897 S-adenosylmethionine binding site [chemical binding]; other site 585054009898 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 585054009899 TrkA-N domain; Region: TrkA_N; pfam02254 585054009900 TrkA-C domain; Region: TrkA_C; pfam02080 585054009901 TrkA-N domain; Region: TrkA_N; pfam02254 585054009902 TrkA-C domain; Region: TrkA_C; pfam02080 585054009903 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 585054009904 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 585054009905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 585054009906 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 585054009907 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 585054009908 DNA binding residues [nucleotide binding] 585054009909 dimer interface [polypeptide binding]; other site 585054009910 metal binding site [ion binding]; metal-binding site 585054009911 hypothetical protein; Provisional; Region: PRK10203 585054009912 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 585054009913 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 585054009914 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 585054009915 alphaNTD homodimer interface [polypeptide binding]; other site 585054009916 alphaNTD - beta interaction site [polypeptide binding]; other site 585054009917 alphaNTD - beta' interaction site [polypeptide binding]; other site 585054009918 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 585054009919 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 585054009920 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 585054009921 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054009922 RNA binding surface [nucleotide binding]; other site 585054009923 30S ribosomal protein S11; Validated; Region: PRK05309 585054009924 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 585054009925 30S ribosomal protein S13; Region: bact_S13; TIGR03631 585054009926 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 585054009927 SecY translocase; Region: SecY; pfam00344 585054009928 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 585054009929 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 585054009930 23S rRNA binding site [nucleotide binding]; other site 585054009931 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 585054009932 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 585054009933 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 585054009934 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 585054009935 23S rRNA interface [nucleotide binding]; other site 585054009936 5S rRNA interface [nucleotide binding]; other site 585054009937 L27 interface [polypeptide binding]; other site 585054009938 L5 interface [polypeptide binding]; other site 585054009939 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 585054009940 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585054009941 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585054009942 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 585054009943 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 585054009944 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 585054009945 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 585054009946 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 585054009947 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 585054009948 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 585054009949 RNA binding site [nucleotide binding]; other site 585054009950 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 585054009951 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 585054009952 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 585054009953 23S rRNA interface [nucleotide binding]; other site 585054009954 putative translocon interaction site; other site 585054009955 signal recognition particle (SRP54) interaction site; other site 585054009956 L23 interface [polypeptide binding]; other site 585054009957 trigger factor interaction site; other site 585054009958 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 585054009959 23S rRNA interface [nucleotide binding]; other site 585054009960 5S rRNA interface [nucleotide binding]; other site 585054009961 putative antibiotic binding site [chemical binding]; other site 585054009962 L25 interface [polypeptide binding]; other site 585054009963 L27 interface [polypeptide binding]; other site 585054009964 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 585054009965 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 585054009966 G-X-X-G motif; other site 585054009967 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 585054009968 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 585054009969 protein-rRNA interface [nucleotide binding]; other site 585054009970 putative translocon binding site; other site 585054009971 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 585054009972 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 585054009973 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 585054009974 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 585054009975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 585054009976 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 585054009977 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 585054009978 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 585054009979 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585054009980 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585054009981 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 585054009982 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 585054009983 heme binding site [chemical binding]; other site 585054009984 ferroxidase pore; other site 585054009985 ferroxidase diiron center [ion binding]; other site 585054009986 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 585054009987 elongation factor Tu; Reviewed; Region: PRK00049 585054009988 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585054009989 G1 box; other site 585054009990 GEF interaction site [polypeptide binding]; other site 585054009991 GTP/Mg2+ binding site [chemical binding]; other site 585054009992 Switch I region; other site 585054009993 G2 box; other site 585054009994 G3 box; other site 585054009995 Switch II region; other site 585054009996 G4 box; other site 585054009997 G5 box; other site 585054009998 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585054009999 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585054010000 Antibiotic Binding Site [chemical binding]; other site 585054010001 elongation factor G; Reviewed; Region: PRK00007 585054010002 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 585054010003 G1 box; other site 585054010004 putative GEF interaction site [polypeptide binding]; other site 585054010005 GTP/Mg2+ binding site [chemical binding]; other site 585054010006 Switch I region; other site 585054010007 G2 box; other site 585054010008 G3 box; other site 585054010009 Switch II region; other site 585054010010 G4 box; other site 585054010011 G5 box; other site 585054010012 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 585054010013 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 585054010014 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 585054010015 30S ribosomal protein S7; Validated; Region: PRK05302 585054010016 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 585054010017 S17 interaction site [polypeptide binding]; other site 585054010018 S8 interaction site; other site 585054010019 16S rRNA interaction site [nucleotide binding]; other site 585054010020 streptomycin interaction site [chemical binding]; other site 585054010021 23S rRNA interaction site [nucleotide binding]; other site 585054010022 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 585054010023 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 585054010024 sulfur relay protein TusC; Validated; Region: PRK00211 585054010025 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 585054010026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 585054010027 YheO-like PAS domain; Region: PAS_6; pfam08348 585054010028 HTH domain; Region: HTH_22; pfam13309 585054010029 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 585054010030 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585054010031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585054010032 phi X174 lysis protein; Provisional; Region: PRK02793 585054010033 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585054010034 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585054010035 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 585054010036 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 585054010037 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585054010038 TrkA-N domain; Region: TrkA_N; pfam02254 585054010039 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 585054010040 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 585054010041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054010042 Walker A/P-loop; other site 585054010043 ATP binding site [chemical binding]; other site 585054010044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585054010045 ABC transporter signature motif; other site 585054010046 Walker B; other site 585054010047 D-loop; other site 585054010048 ABC transporter; Region: ABC_tran_2; pfam12848 585054010049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585054010050 putative hydrolase; Provisional; Region: PRK10985 585054010051 hypothetical protein; Provisional; Region: PRK04966 585054010052 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 585054010053 active site 585054010054 hypothetical protein; Provisional; Region: PRK10738 585054010055 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 585054010056 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585054010057 ligand binding site [chemical binding]; other site 585054010058 flexible hinge region; other site 585054010059 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585054010060 putative switch regulator; other site 585054010061 non-specific DNA interactions [nucleotide binding]; other site 585054010062 DNA binding site [nucleotide binding] 585054010063 sequence specific DNA binding site [nucleotide binding]; other site 585054010064 putative cAMP binding site [chemical binding]; other site 585054010065 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 585054010066 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585054010067 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585054010068 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 585054010069 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585054010070 inhibitor-cofactor binding pocket; inhibition site 585054010071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054010072 catalytic residue [active] 585054010073 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 585054010074 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585054010075 glutamine binding [chemical binding]; other site 585054010076 catalytic triad [active] 585054010077 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 585054010078 cell filamentation protein Fic; Provisional; Region: PRK10347 585054010079 hypothetical protein; Provisional; Region: PRK10204 585054010080 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 585054010081 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585054010082 substrate binding site [chemical binding]; other site 585054010083 nitrite reductase subunit NirD; Provisional; Region: PRK14989 585054010084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054010085 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585054010086 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585054010087 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585054010088 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 585054010089 nitrite transporter NirC; Provisional; Region: PRK11562 585054010090 siroheme synthase; Provisional; Region: cysG; PRK10637 585054010091 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 585054010092 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 585054010093 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 585054010094 active site 585054010095 SAM binding site [chemical binding]; other site 585054010096 homodimer interface [polypeptide binding]; other site 585054010097 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 585054010098 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 585054010099 Protein of unknown function; Region: YhfT; pfam10797 585054010100 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 585054010101 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585054010102 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585054010103 active site 585054010104 substrate binding pocket [chemical binding]; other site 585054010105 homodimer interaction site [polypeptide binding]; other site 585054010106 putative mutase; Provisional; Region: PRK12383 585054010107 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 585054010108 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 585054010109 dimer interface [polypeptide binding]; other site 585054010110 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 585054010111 active site 585054010112 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054010113 substrate binding site [chemical binding]; other site 585054010114 catalytic residue [active] 585054010115 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 585054010116 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 585054010117 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 585054010118 active site 585054010119 HIGH motif; other site 585054010120 dimer interface [polypeptide binding]; other site 585054010121 KMSKS motif; other site 585054010122 phosphoglycolate phosphatase; Provisional; Region: PRK13222 585054010123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054010124 motif II; other site 585054010125 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585054010126 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 585054010127 substrate binding site [chemical binding]; other site 585054010128 hexamer interface [polypeptide binding]; other site 585054010129 metal binding site [ion binding]; metal-binding site 585054010130 DNA adenine methylase; Provisional; Region: PRK10904 585054010131 cell division protein DamX; Validated; Region: PRK10905 585054010132 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 585054010133 active site 585054010134 dimer interface [polypeptide binding]; other site 585054010135 metal binding site [ion binding]; metal-binding site 585054010136 shikimate kinase; Reviewed; Region: aroK; PRK00131 585054010137 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585054010138 ADP binding site [chemical binding]; other site 585054010139 magnesium binding site [ion binding]; other site 585054010140 putative shikimate binding site; other site 585054010141 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 585054010142 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585054010143 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585054010144 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 585054010145 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 585054010146 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 585054010147 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 585054010148 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 585054010149 Transglycosylase; Region: Transgly; pfam00912 585054010150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585054010151 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 585054010152 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585054010153 ADP-ribose binding site [chemical binding]; other site 585054010154 dimer interface [polypeptide binding]; other site 585054010155 active site 585054010156 nudix motif; other site 585054010157 metal binding site [ion binding]; metal-binding site 585054010158 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 585054010159 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585054010160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054010161 motif II; other site 585054010162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054010163 RNA binding surface [nucleotide binding]; other site 585054010164 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 585054010165 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 585054010166 dimerization interface [polypeptide binding]; other site 585054010167 domain crossover interface; other site 585054010168 redox-dependent activation switch; other site 585054010169 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 585054010170 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 585054010171 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 585054010172 active site 585054010173 substrate-binding site [chemical binding]; other site 585054010174 metal-binding site [ion binding] 585054010175 ATP binding site [chemical binding]; other site 585054010176 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 585054010177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054010178 non-specific DNA binding site [nucleotide binding]; other site 585054010179 salt bridge; other site 585054010180 sequence-specific DNA binding site [nucleotide binding]; other site 585054010181 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 585054010182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054010183 dimerization interface [polypeptide binding]; other site 585054010184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054010185 dimer interface [polypeptide binding]; other site 585054010186 phosphorylation site [posttranslational modification] 585054010187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054010188 ATP binding site [chemical binding]; other site 585054010189 G-X-G motif; other site 585054010190 osmolarity response regulator; Provisional; Region: ompR; PRK09468 585054010191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054010192 active site 585054010193 phosphorylation site [posttranslational modification] 585054010194 intermolecular recognition site; other site 585054010195 dimerization interface [polypeptide binding]; other site 585054010196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054010197 DNA binding site [nucleotide binding] 585054010198 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 585054010199 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585054010200 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585054010201 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 585054010202 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 585054010203 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 585054010204 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 585054010205 RNA binding site [nucleotide binding]; other site 585054010206 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 585054010207 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 585054010208 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 585054010209 G1 box; other site 585054010210 GTP/Mg2+ binding site [chemical binding]; other site 585054010211 Switch I region; other site 585054010212 G2 box; other site 585054010213 G3 box; other site 585054010214 Switch II region; other site 585054010215 G4 box; other site 585054010216 G5 box; other site 585054010217 Nucleoside recognition; Region: Gate; pfam07670 585054010218 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 585054010219 Nucleoside recognition; Region: Gate; pfam07670 585054010220 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 585054010221 putative transposase; Provisional; Region: PRK09857 585054010222 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585054010223 carboxylesterase BioH; Provisional; Region: PRK10349 585054010224 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 585054010225 DNA utilization protein GntX; Provisional; Region: PRK11595 585054010226 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054010227 active site 585054010228 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 585054010229 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 585054010230 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 585054010231 high-affinity gluconate transporter; Provisional; Region: PRK14984 585054010232 gluconate transporter; Region: gntP; TIGR00791 585054010233 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 585054010234 4-alpha-glucanotransferase; Region: malQ; TIGR00217 585054010235 maltodextrin phosphorylase; Provisional; Region: PRK14985 585054010236 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585054010237 homodimer interface [polypeptide binding]; other site 585054010238 active site pocket [active] 585054010239 transcriptional regulator MalT; Provisional; Region: PRK04841 585054010240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054010241 DNA binding residues [nucleotide binding] 585054010242 dimerization interface [polypeptide binding]; other site 585054010243 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 585054010244 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 585054010245 putative active site [active] 585054010246 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 585054010247 hypothetical protein; Reviewed; Region: PRK09588 585054010248 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 585054010249 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 585054010250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054010251 Walker A motif; other site 585054010252 ATP binding site [chemical binding]; other site 585054010253 Walker B motif; other site 585054010254 arginine finger; other site 585054010255 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 585054010256 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585054010257 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585054010258 intramembrane serine protease GlpG; Provisional; Region: PRK10907 585054010259 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 585054010260 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585054010261 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 585054010262 active site residue [active] 585054010263 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 585054010264 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 585054010265 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 585054010266 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 585054010267 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 585054010268 Fimbrial protein; Region: Fimbrial; cl01416 585054010269 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585054010270 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054010271 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054010272 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585054010273 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585054010274 outer membrane usher protein; Provisional; Region: PRK15193 585054010275 PapC N-terminal domain; Region: PapC_N; pfam13954 585054010276 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585054010277 PapC C-terminal domain; Region: PapC_C; pfam13953 585054010278 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585054010279 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585054010280 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585054010281 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585054010282 glycogen phosphorylase; Provisional; Region: PRK14986 585054010283 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585054010284 homodimer interface [polypeptide binding]; other site 585054010285 active site pocket [active] 585054010286 glycogen synthase; Provisional; Region: glgA; PRK00654 585054010287 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 585054010288 ADP-binding pocket [chemical binding]; other site 585054010289 homodimer interface [polypeptide binding]; other site 585054010290 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 585054010291 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 585054010292 ligand binding site; other site 585054010293 oligomer interface; other site 585054010294 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 585054010295 sulfate 1 binding site; other site 585054010296 glycogen debranching enzyme; Provisional; Region: PRK03705 585054010297 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 585054010298 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 585054010299 active site 585054010300 catalytic site [active] 585054010301 glycogen branching enzyme; Provisional; Region: PRK05402 585054010302 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 585054010303 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 585054010304 active site 585054010305 catalytic site [active] 585054010306 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 585054010307 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 585054010308 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585054010309 putative antibiotic transporter; Provisional; Region: PRK10739 585054010310 low affinity gluconate transporter; Provisional; Region: PRK10472 585054010311 gluconate transporter; Region: gntP; TIGR00791 585054010312 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 585054010313 ATP-binding site [chemical binding]; other site 585054010314 Gluconate-6-phosphate binding site [chemical binding]; other site 585054010315 Shikimate kinase; Region: SKI; pfam01202 585054010316 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 585054010317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054010318 DNA binding site [nucleotide binding] 585054010319 domain linker motif; other site 585054010320 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585054010321 putative ligand binding site [chemical binding]; other site 585054010322 putative dimerization interface [polypeptide binding]; other site 585054010323 Pirin-related protein [General function prediction only]; Region: COG1741 585054010324 Pirin; Region: Pirin; pfam02678 585054010325 putative oxidoreductase; Provisional; Region: PRK10206 585054010326 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585054010327 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585054010328 putative acetyltransferase YhhY; Provisional; Region: PRK10140 585054010329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054010330 Coenzyme A binding pocket [chemical binding]; other site 585054010331 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 585054010332 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 585054010333 hypothetical protein; Provisional; Region: PRK10350 585054010334 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 585054010335 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 585054010336 putative active site [active] 585054010337 catalytic site [active] 585054010338 putative metal binding site [ion binding]; other site 585054010339 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 585054010340 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585054010341 Walker A/P-loop; other site 585054010342 ATP binding site [chemical binding]; other site 585054010343 Q-loop/lid; other site 585054010344 ABC transporter signature motif; other site 585054010345 Walker B; other site 585054010346 D-loop; other site 585054010347 H-loop/switch region; other site 585054010348 TOBE domain; Region: TOBE_2; pfam08402 585054010349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585054010350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054010351 dimer interface [polypeptide binding]; other site 585054010352 conserved gate region; other site 585054010353 putative PBP binding loops; other site 585054010354 ABC-ATPase subunit interface; other site 585054010355 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 585054010356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054010357 dimer interface [polypeptide binding]; other site 585054010358 conserved gate region; other site 585054010359 putative PBP binding loops; other site 585054010360 ABC-ATPase subunit interface; other site 585054010361 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 585054010362 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585054010363 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 585054010364 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 585054010365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585054010366 binding surface 585054010367 TPR motif; other site 585054010368 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 585054010369 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 585054010370 Walker A/P-loop; other site 585054010371 ATP binding site [chemical binding]; other site 585054010372 Q-loop/lid; other site 585054010373 ABC transporter signature motif; other site 585054010374 Walker B; other site 585054010375 D-loop; other site 585054010376 H-loop/switch region; other site 585054010377 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 585054010378 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 585054010379 Walker A/P-loop; other site 585054010380 ATP binding site [chemical binding]; other site 585054010381 Q-loop/lid; other site 585054010382 ABC transporter signature motif; other site 585054010383 Walker B; other site 585054010384 D-loop; other site 585054010385 H-loop/switch region; other site 585054010386 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 585054010387 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 585054010388 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 585054010389 TM-ABC transporter signature motif; other site 585054010390 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054010391 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 585054010392 TM-ABC transporter signature motif; other site 585054010393 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585054010394 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585054010395 dimerization interface [polypeptide binding]; other site 585054010396 ligand binding site [chemical binding]; other site 585054010397 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 585054010398 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585054010399 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585054010400 dimerization interface [polypeptide binding]; other site 585054010401 ligand binding site [chemical binding]; other site 585054010402 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 585054010403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585054010404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585054010405 DNA binding residues [nucleotide binding] 585054010406 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 585054010407 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 585054010408 cell division protein FtsE; Provisional; Region: PRK10908 585054010409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054010410 Walker A/P-loop; other site 585054010411 ATP binding site [chemical binding]; other site 585054010412 Q-loop/lid; other site 585054010413 ABC transporter signature motif; other site 585054010414 Walker B; other site 585054010415 D-loop; other site 585054010416 H-loop/switch region; other site 585054010417 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 585054010418 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 585054010419 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585054010420 P loop; other site 585054010421 GTP binding site [chemical binding]; other site 585054010422 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 585054010423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054010424 S-adenosylmethionine binding site [chemical binding]; other site 585054010425 hypothetical protein; Provisional; Region: PRK10910 585054010426 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 585054010427 Predicted membrane protein [Function unknown]; Region: COG3714 585054010428 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 585054010429 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585054010430 metal-binding site [ion binding] 585054010431 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585054010432 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 585054010433 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 585054010434 CPxP motif; other site 585054010435 hypothetical protein; Provisional; Region: PRK11212 585054010436 hypothetical protein; Provisional; Region: PRK11615 585054010437 major facilitator superfamily transporter; Provisional; Region: PRK05122 585054010438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010439 putative substrate translocation pore; other site 585054010440 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 585054010441 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585054010442 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 585054010443 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585054010444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054010445 S-adenosylmethionine binding site [chemical binding]; other site 585054010446 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 585054010447 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585054010448 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 585054010449 putative acyl-acceptor binding pocket; other site 585054010450 Phosphopantetheine attachment site; Region: PP-binding; cl09936 585054010451 acyl carrier protein; Provisional; Region: PRK05350 585054010452 Predicted membrane protein [Function unknown]; Region: COG4648 585054010453 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 585054010454 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 585054010455 acyl-activating enzyme (AAE) consensus motif; other site 585054010456 active site 585054010457 AMP binding site [chemical binding]; other site 585054010458 CoA binding site [chemical binding]; other site 585054010459 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 585054010460 active site 2 [active] 585054010461 active site 1 [active] 585054010462 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585054010463 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 585054010464 Ligand binding site; other site 585054010465 Putative Catalytic site; other site 585054010466 DXD motif; other site 585054010467 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585054010468 putative acyl-acceptor binding pocket; other site 585054010469 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585054010470 active site 585054010471 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 585054010472 Predicted exporter [General function prediction only]; Region: COG4258 585054010473 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 585054010474 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 585054010475 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585054010476 dimer interface [polypeptide binding]; other site 585054010477 active site 585054010478 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 585054010479 putative active site 1 [active] 585054010480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585054010481 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 585054010482 NAD(P) binding site [chemical binding]; other site 585054010483 active site 585054010484 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 585054010485 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585054010486 dimer interface [polypeptide binding]; other site 585054010487 active site 585054010488 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 585054010489 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 585054010490 nickel responsive regulator; Provisional; Region: PRK02967 585054010491 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 585054010492 putative lyase; Provisional; Region: PRK09687 585054010493 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585054010494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054010495 DNA-binding site [nucleotide binding]; DNA binding site 585054010496 UTRA domain; Region: UTRA; pfam07702 585054010497 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054010498 active site 585054010499 phosphorylation site [posttranslational modification] 585054010500 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585054010501 active site 585054010502 P-loop; other site 585054010503 phosphorylation site [posttranslational modification] 585054010504 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585054010505 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 585054010506 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585054010507 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 585054010508 putative N- and C-terminal domain interface [polypeptide binding]; other site 585054010509 putative active site [active] 585054010510 putative MgATP binding site [chemical binding]; other site 585054010511 catalytic site [active] 585054010512 metal binding site [ion binding]; metal-binding site 585054010513 putative carbohydrate binding site [chemical binding]; other site 585054010514 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585054010515 dimerization domain swap beta strand [polypeptide binding]; other site 585054010516 regulatory protein interface [polypeptide binding]; other site 585054010517 active site 585054010518 regulatory phosphorylation site [posttranslational modification]; other site 585054010519 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585054010520 intersubunit interface [polypeptide binding]; other site 585054010521 active site 585054010522 zinc binding site [ion binding]; other site 585054010523 Na+ binding site [ion binding]; other site 585054010524 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585054010525 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585054010526 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585054010527 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 585054010528 Walker A/P-loop; other site 585054010529 ATP binding site [chemical binding]; other site 585054010530 Q-loop/lid; other site 585054010531 ABC transporter signature motif; other site 585054010532 Walker B; other site 585054010533 D-loop; other site 585054010534 H-loop/switch region; other site 585054010535 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585054010536 Walker A/P-loop; other site 585054010537 ATP binding site [chemical binding]; other site 585054010538 Q-loop/lid; other site 585054010539 ABC transporter signature motif; other site 585054010540 Walker B; other site 585054010541 D-loop; other site 585054010542 H-loop/switch region; other site 585054010543 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585054010544 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585054010545 HlyD family secretion protein; Region: HlyD; pfam00529 585054010546 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054010547 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054010548 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 585054010549 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010550 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010551 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010552 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 585054010553 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010554 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010555 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010556 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010557 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010558 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010559 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010560 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 585054010561 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 585054010562 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 585054010563 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 585054010564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585054010565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054010566 Walker A/P-loop; other site 585054010567 ATP binding site [chemical binding]; other site 585054010568 Q-loop/lid; other site 585054010569 ABC transporter signature motif; other site 585054010570 Walker B; other site 585054010571 D-loop; other site 585054010572 H-loop/switch region; other site 585054010573 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 585054010574 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 585054010575 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054010576 Predicted flavoproteins [General function prediction only]; Region: COG2081 585054010577 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585054010578 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585054010579 universal stress protein UspB; Provisional; Region: PRK04960 585054010580 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054010581 Ligand Binding Site [chemical binding]; other site 585054010582 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 585054010583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010584 putative substrate translocation pore; other site 585054010585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054010586 S-adenosylmethionine binding site [chemical binding]; other site 585054010587 oligopeptidase A; Provisional; Region: PRK10911 585054010588 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585054010589 active site 585054010590 Zn binding site [ion binding]; other site 585054010591 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 585054010592 glutathione reductase; Validated; Region: PRK06116 585054010593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585054010594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054010595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585054010596 glutathione reductase; Validated; Region: PRK06116 585054010597 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054010598 dimerization interface [polypeptide binding]; other site 585054010599 putative DNA binding site [nucleotide binding]; other site 585054010600 putative Zn2+ binding site [ion binding]; other site 585054010601 arsenical pump membrane protein; Provisional; Region: PRK15445 585054010602 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 585054010603 transmembrane helices; other site 585054010604 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585054010605 ArsC family; Region: ArsC; pfam03960 585054010606 catalytic residues [active] 585054010607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054010608 dimerization interface [polypeptide binding]; other site 585054010609 putative DNA binding site [nucleotide binding]; other site 585054010610 putative Zn2+ binding site [ion binding]; other site 585054010611 Predicted permeases [General function prediction only]; Region: COG0701 585054010612 trehalase; Provisional; Region: treF; PRK13270 585054010613 Trehalase; Region: Trehalase; pfam01204 585054010614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585054010615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054010616 DNA binding residues [nucleotide binding] 585054010617 dimerization interface [polypeptide binding]; other site 585054010618 inner membrane protein YhjD; Region: TIGR00766 585054010619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010620 metabolite-proton symporter; Region: 2A0106; TIGR00883 585054010621 putative substrate translocation pore; other site 585054010622 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 585054010623 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585054010624 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054010625 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585054010626 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585054010627 substrate binding site [chemical binding]; other site 585054010628 ATP binding site [chemical binding]; other site 585054010629 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 585054010630 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585054010631 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585054010632 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585054010633 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 585054010634 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585054010635 putative diguanylate cyclase; Provisional; Region: PRK13561 585054010636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585054010637 metal binding site [ion binding]; metal-binding site 585054010638 active site 585054010639 I-site; other site 585054010640 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585054010641 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 585054010642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585054010643 binding surface 585054010644 TPR motif; other site 585054010645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585054010646 binding surface 585054010647 TPR motif; other site 585054010648 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 585054010649 endo-1,4-D-glucanase; Provisional; Region: PRK11097 585054010650 cellulose synthase regulator protein; Provisional; Region: PRK11114 585054010651 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 585054010652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585054010653 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 585054010654 DXD motif; other site 585054010655 PilZ domain; Region: PilZ; pfam07238 585054010656 cell division protein; Provisional; Region: PRK10037 585054010657 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 585054010658 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 585054010659 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 585054010660 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 585054010661 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 585054010662 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585054010663 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585054010664 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585054010665 methionine gamma-lyase; Provisional; Region: PRK06234 585054010666 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585054010667 homodimer interface [polypeptide binding]; other site 585054010668 substrate-cofactor binding pocket; other site 585054010669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054010670 catalytic residue [active] 585054010671 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585054010672 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 585054010673 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 585054010674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054010675 Walker A motif; other site 585054010676 ATP binding site [chemical binding]; other site 585054010677 Walker B motif; other site 585054010678 arginine finger; other site 585054010679 Helix-turn-helix domain; Region: HTH_38; pfam13936 585054010680 DNA-binding interface [nucleotide binding]; DNA binding site 585054010681 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 585054010682 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054010683 Walker A/P-loop; other site 585054010684 ATP binding site [chemical binding]; other site 585054010685 Q-loop/lid; other site 585054010686 ABC transporter signature motif; other site 585054010687 Walker B; other site 585054010688 D-loop; other site 585054010689 H-loop/switch region; other site 585054010690 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585054010691 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 585054010692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585054010693 Walker A/P-loop; other site 585054010694 ATP binding site [chemical binding]; other site 585054010695 Q-loop/lid; other site 585054010696 ABC transporter signature motif; other site 585054010697 Walker B; other site 585054010698 D-loop; other site 585054010699 H-loop/switch region; other site 585054010700 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585054010701 dipeptide transporter; Provisional; Region: PRK10913 585054010702 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585054010703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054010704 dimer interface [polypeptide binding]; other site 585054010705 conserved gate region; other site 585054010706 putative PBP binding loops; other site 585054010707 ABC-ATPase subunit interface; other site 585054010708 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585054010709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054010710 dimer interface [polypeptide binding]; other site 585054010711 conserved gate region; other site 585054010712 putative PBP binding loops; other site 585054010713 ABC-ATPase subunit interface; other site 585054010714 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585054010715 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585054010716 peptide binding site [polypeptide binding]; other site 585054010717 phosphoethanolamine transferase; Provisional; Region: PRK11560 585054010718 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585054010719 Sulfatase; Region: Sulfatase; pfam00884 585054010720 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 585054010721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010722 putative substrate translocation pore; other site 585054010723 Autotransporter beta-domain; Region: Autotransporter; cl17461 585054010724 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 585054010725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585054010726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054010727 Coenzyme A binding pocket [chemical binding]; other site 585054010728 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585054010729 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585054010730 molybdopterin cofactor binding site [chemical binding]; other site 585054010731 substrate binding site [chemical binding]; other site 585054010732 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585054010733 molybdopterin cofactor binding site; other site 585054010734 putative outer membrane lipoprotein; Provisional; Region: PRK10510 585054010735 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585054010736 ligand binding site [chemical binding]; other site 585054010737 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054010738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054010739 DNA binding site [nucleotide binding] 585054010740 domain linker motif; other site 585054010741 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 585054010742 putative dimerization interface [polypeptide binding]; other site 585054010743 putative ligand binding site [chemical binding]; other site 585054010744 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585054010745 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585054010746 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585054010747 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585054010748 substrate binding site [chemical binding]; other site 585054010749 ATP binding site [chemical binding]; other site 585054010750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010751 D-galactonate transporter; Region: 2A0114; TIGR00893 585054010752 putative substrate translocation pore; other site 585054010753 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 585054010754 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 585054010755 dimerization interface [polypeptide binding]; other site 585054010756 ligand binding site [chemical binding]; other site 585054010757 NADP binding site [chemical binding]; other site 585054010758 catalytic site [active] 585054010759 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 585054010760 benzoate transport; Region: 2A0115; TIGR00895 585054010761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010762 putative substrate translocation pore; other site 585054010763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054010764 Predicted transcriptional regulator [Transcription]; Region: COG2944 585054010765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054010766 salt bridge; other site 585054010767 non-specific DNA binding site [nucleotide binding]; other site 585054010768 sequence-specific DNA binding site [nucleotide binding]; other site 585054010769 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054010770 DNA-binding site [nucleotide binding]; DNA binding site 585054010771 RNA-binding motif; other site 585054010772 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 585054010773 DALR anticodon binding domain; Region: DALR_1; pfam05746 585054010774 anticodon binding site; other site 585054010775 tRNA binding surface [nucleotide binding]; other site 585054010776 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 585054010777 dimer interface [polypeptide binding]; other site 585054010778 motif 1; other site 585054010779 active site 585054010780 motif 2; other site 585054010781 motif 3; other site 585054010782 YsaB-like lipoprotein; Region: YsaB; pfam13983 585054010783 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 585054010784 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585054010785 hypothetical protein; Provisional; Region: PRK11403 585054010786 yiaA/B two helix domain; Region: YiaAB; pfam05360 585054010787 xylulokinase; Provisional; Region: PRK15027 585054010788 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 585054010789 N- and C-terminal domain interface [polypeptide binding]; other site 585054010790 active site 585054010791 MgATP binding site [chemical binding]; other site 585054010792 catalytic site [active] 585054010793 metal binding site [ion binding]; metal-binding site 585054010794 xylulose binding site [chemical binding]; other site 585054010795 homodimer interface [polypeptide binding]; other site 585054010796 xylose isomerase; Provisional; Region: PRK05474 585054010797 xylose isomerase; Region: xylose_isom_A; TIGR02630 585054010798 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 585054010799 putative dimerization interface [polypeptide binding]; other site 585054010800 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054010801 putative ligand binding site [chemical binding]; other site 585054010802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054010803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585054010804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054010805 hypothetical protein; Provisional; Region: PRK10356 585054010806 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 585054010807 alpha-amylase; Reviewed; Region: malS; PRK09505 585054010808 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 585054010809 active site 585054010810 catalytic site [active] 585054010811 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 585054010812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054010813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054010814 homodimer interface [polypeptide binding]; other site 585054010815 catalytic residue [active] 585054010816 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585054010817 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 585054010818 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585054010819 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585054010820 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054010821 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 585054010822 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 585054010823 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 585054010824 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 585054010825 DctM-like transporters; Region: DctM; pfam06808 585054010826 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585054010827 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585054010828 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585054010829 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 585054010830 putative N- and C-terminal domain interface [polypeptide binding]; other site 585054010831 putative active site [active] 585054010832 MgATP binding site [chemical binding]; other site 585054010833 catalytic site [active] 585054010834 metal binding site [ion binding]; metal-binding site 585054010835 putative xylulose binding site [chemical binding]; other site 585054010836 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585054010837 active site 585054010838 dimer interface [polypeptide binding]; other site 585054010839 magnesium binding site [ion binding]; other site 585054010840 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 585054010841 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585054010842 AP (apurinic/apyrimidinic) site pocket; other site 585054010843 DNA interaction; other site 585054010844 Metal-binding active site; metal-binding site 585054010845 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585054010846 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585054010847 intersubunit interface [polypeptide binding]; other site 585054010848 active site 585054010849 Zn2+ binding site [ion binding]; other site 585054010850 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 585054010851 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585054010852 NAD(P) binding site [chemical binding]; other site 585054010853 catalytic residues [active] 585054010854 putative alcohol dehydrogenase; Provisional; Region: PRK09860 585054010855 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585054010856 dimer interface [polypeptide binding]; other site 585054010857 active site 585054010858 metal binding site [ion binding]; metal-binding site 585054010859 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 585054010860 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 585054010861 G1 box; other site 585054010862 putative GEF interaction site [polypeptide binding]; other site 585054010863 GTP/Mg2+ binding site [chemical binding]; other site 585054010864 Switch I region; other site 585054010865 G2 box; other site 585054010866 G3 box; other site 585054010867 Switch II region; other site 585054010868 G4 box; other site 585054010869 G5 box; other site 585054010870 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 585054010871 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 585054010872 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 585054010873 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 585054010874 selenocysteine synthase; Provisional; Region: PRK04311 585054010875 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 585054010876 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 585054010877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585054010878 catalytic residue [active] 585054010879 putative glutathione S-transferase; Provisional; Region: PRK10357 585054010880 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 585054010881 putative C-terminal domain interface [polypeptide binding]; other site 585054010882 putative GSH binding site (G-site) [chemical binding]; other site 585054010883 putative dimer interface [polypeptide binding]; other site 585054010884 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 585054010885 dimer interface [polypeptide binding]; other site 585054010886 N-terminal domain interface [polypeptide binding]; other site 585054010887 putative substrate binding pocket (H-site) [chemical binding]; other site 585054010888 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585054010889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054010890 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054010891 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585054010892 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 585054010893 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585054010894 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585054010895 active site 585054010896 P-loop; other site 585054010897 phosphorylation site [posttranslational modification] 585054010898 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054010899 active site 585054010900 phosphorylation site [posttranslational modification] 585054010901 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 585054010902 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585054010903 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585054010904 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585054010905 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 585054010906 hypothetical protein; Provisional; Region: PRK11020 585054010907 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585054010908 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585054010909 trimer interface [polypeptide binding]; other site 585054010910 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585054010911 trimer interface [polypeptide binding]; other site 585054010912 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 585054010913 trimer interface [polypeptide binding]; other site 585054010914 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585054010915 trimer interface [polypeptide binding]; other site 585054010916 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 585054010917 Haemagglutinin; Region: HIM; pfam05662 585054010918 Haemagglutinin; Region: HIM; pfam05662 585054010919 YadA-like C-terminal region; Region: YadA; pfam03895 585054010920 L-lactate permease; Provisional; Region: PRK10420 585054010921 glycolate transporter; Provisional; Region: PRK09695 585054010922 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 585054010923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054010924 DNA-binding site [nucleotide binding]; DNA binding site 585054010925 FCD domain; Region: FCD; pfam07729 585054010926 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 585054010927 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 585054010928 active site 585054010929 substrate binding site [chemical binding]; other site 585054010930 FMN binding site [chemical binding]; other site 585054010931 putative catalytic residues [active] 585054010932 putative rRNA methylase; Provisional; Region: PRK10358 585054010933 serine acetyltransferase; Provisional; Region: cysE; PRK11132 585054010934 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 585054010935 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585054010936 trimer interface [polypeptide binding]; other site 585054010937 active site 585054010938 substrate binding site [chemical binding]; other site 585054010939 CoA binding site [chemical binding]; other site 585054010940 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 585054010941 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585054010942 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 585054010943 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 585054010944 SecA binding site; other site 585054010945 Preprotein binding site; other site 585054010946 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 585054010947 GSH binding site [chemical binding]; other site 585054010948 catalytic residues [active] 585054010949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585054010950 active site residue [active] 585054010951 phosphoglyceromutase; Provisional; Region: PRK05434 585054010952 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 585054010953 AmiB activator; Provisional; Region: PRK11637 585054010954 Peptidase family M23; Region: Peptidase_M23; pfam01551 585054010955 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 585054010956 NodB motif; other site 585054010957 putative active site [active] 585054010958 putative catalytic site [active] 585054010959 Zn binding site [ion binding]; other site 585054010960 putative glycosyl transferase; Provisional; Region: PRK10073 585054010961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585054010962 active site 585054010963 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 585054010964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054010965 FeS/SAM binding site; other site 585054010966 HemN C-terminal domain; Region: HemN_C; pfam06969 585054010967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 585054010968 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 585054010969 G1 box; other site 585054010970 GTP/Mg2+ binding site [chemical binding]; other site 585054010971 Switch I region; other site 585054010972 G2 box; other site 585054010973 G3 box; other site 585054010974 Switch II region; other site 585054010975 G4 box; other site 585054010976 G5 box; other site 585054010977 DNA polymerase I; Provisional; Region: PRK05755 585054010978 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585054010979 active site 585054010980 metal binding site 1 [ion binding]; metal-binding site 585054010981 putative 5' ssDNA interaction site; other site 585054010982 metal binding site 3; metal-binding site 585054010983 metal binding site 2 [ion binding]; metal-binding site 585054010984 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585054010985 putative DNA binding site [nucleotide binding]; other site 585054010986 putative metal binding site [ion binding]; other site 585054010987 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 585054010988 active site 585054010989 catalytic site [active] 585054010990 substrate binding site [chemical binding]; other site 585054010991 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 585054010992 active site 585054010993 DNA binding site [nucleotide binding] 585054010994 catalytic site [active] 585054010995 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 585054010996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 585054010997 putative acyl-acceptor binding pocket; other site 585054010998 hypothetical protein; Provisional; Region: PRK11367 585054010999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585054011000 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585054011001 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585054011002 catalytic residues [active] 585054011003 hinge region; other site 585054011004 alpha helical domain; other site 585054011005 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 585054011006 serine/threonine protein kinase; Provisional; Region: PRK11768 585054011007 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 585054011008 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 585054011009 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 585054011010 GTP binding site; other site 585054011011 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 585054011012 Walker A motif; other site 585054011013 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 585054011014 potassium transporter; Provisional; Region: PRK10750 585054011015 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 585054011016 hypothetical protein; Provisional; Region: PRK11568 585054011017 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 585054011018 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 585054011019 proline dipeptidase; Provisional; Region: PRK13607 585054011020 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585054011021 active site 585054011022 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 585054011023 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054011024 substrate binding site [chemical binding]; other site 585054011025 oxyanion hole (OAH) forming residues; other site 585054011026 trimer interface [polypeptide binding]; other site 585054011027 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585054011028 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585054011029 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585054011030 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 585054011031 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585054011032 dimer interface [polypeptide binding]; other site 585054011033 active site 585054011034 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 585054011035 FMN reductase; Validated; Region: fre; PRK08051 585054011036 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 585054011037 FAD binding pocket [chemical binding]; other site 585054011038 FAD binding motif [chemical binding]; other site 585054011039 phosphate binding motif [ion binding]; other site 585054011040 beta-alpha-beta structure motif; other site 585054011041 NAD binding pocket [chemical binding]; other site 585054011042 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 585054011043 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 585054011044 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 585054011045 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 585054011046 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585054011047 active site 585054011048 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 585054011049 sec-independent translocase; Provisional; Region: PRK01770 585054011050 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 585054011051 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 585054011052 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 585054011053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 585054011054 SCP-2 sterol transfer family; Region: SCP2; pfam02036 585054011055 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 585054011056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054011057 S-adenosylmethionine binding site [chemical binding]; other site 585054011058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 585054011059 DNA recombination protein RmuC; Provisional; Region: PRK10361 585054011060 RmuC family; Region: RmuC; pfam02646 585054011061 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585054011062 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585054011063 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054011064 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585054011065 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585054011066 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585054011067 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585054011068 active site 585054011069 intersubunit interface [polypeptide binding]; other site 585054011070 catalytic residue [active] 585054011071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 585054011072 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 585054011073 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 585054011074 uridine phosphorylase; Provisional; Region: PRK11178 585054011075 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 585054011076 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585054011077 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 585054011078 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585054011079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054011080 DNA-binding site [nucleotide binding]; DNA binding site 585054011081 UTRA domain; Region: UTRA; pfam07702 585054011082 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 585054011083 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585054011084 active site 585054011085 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 585054011086 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585054011087 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585054011088 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 585054011089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054011090 substrate binding pocket [chemical binding]; other site 585054011091 membrane-bound complex binding site; other site 585054011092 hinge residues; other site 585054011093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585054011094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054011095 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585054011096 putative dimerization interface [polypeptide binding]; other site 585054011097 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 585054011098 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 585054011099 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 585054011100 aconitate hydratase; Validated; Region: PRK07229 585054011101 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 585054011102 substrate binding site [chemical binding]; other site 585054011103 ligand binding site [chemical binding]; other site 585054011104 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 585054011105 substrate binding site [chemical binding]; other site 585054011106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 585054011107 putative hydratase; Provisional; Region: PRK11413 585054011108 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 585054011109 substrate binding site [chemical binding]; other site 585054011110 ligand binding site [chemical binding]; other site 585054011111 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 585054011112 substrate binding site [chemical binding]; other site 585054011113 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 585054011114 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 585054011115 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 585054011116 substrate binding site [chemical binding]; other site 585054011117 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 585054011118 substrate binding site [chemical binding]; other site 585054011119 ligand binding site [chemical binding]; other site 585054011120 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 585054011121 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 585054011122 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 585054011123 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 585054011124 THF binding site; other site 585054011125 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 585054011126 substrate binding site [chemical binding]; other site 585054011127 THF binding site; other site 585054011128 zinc-binding site [ion binding]; other site 585054011129 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 585054011130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054011131 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 585054011132 putative dimerization interface [polypeptide binding]; other site 585054011133 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585054011134 EamA-like transporter family; Region: EamA; pfam00892 585054011135 putative hydrolase; Provisional; Region: PRK10976 585054011136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054011137 active site 585054011138 motif I; other site 585054011139 motif II; other site 585054011140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054011141 lysophospholipase L2; Provisional; Region: PRK10749 585054011142 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585054011143 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 585054011144 putative transposase; Provisional; Region: PRK09857 585054011145 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585054011146 threonine efflux system; Provisional; Region: PRK10229 585054011147 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 585054011148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054011149 ATP binding site [chemical binding]; other site 585054011150 putative Mg++ binding site [ion binding]; other site 585054011151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054011152 nucleotide binding region [chemical binding]; other site 585054011153 ATP-binding site [chemical binding]; other site 585054011154 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 585054011155 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585054011156 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 585054011157 dimerization interface [polypeptide binding]; other site 585054011158 substrate binding site [chemical binding]; other site 585054011159 active site 585054011160 calcium binding site [ion binding]; other site 585054011161 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585054011162 CoenzymeA binding site [chemical binding]; other site 585054011163 subunit interaction site [polypeptide binding]; other site 585054011164 PHB binding site; other site 585054011165 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 585054011166 EamA-like transporter family; Region: EamA; cl17759 585054011167 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 585054011168 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585054011169 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 585054011170 Cl binding site [ion binding]; other site 585054011171 oligomer interface [polypeptide binding]; other site 585054011172 Predicted periplasmic protein [Function unknown]; Region: COG3698 585054011173 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 585054011174 Uncharacterized conserved protein [Function unknown]; Region: COG1912 585054011175 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 585054011176 Part of AAA domain; Region: AAA_19; pfam13245 585054011177 Family description; Region: UvrD_C_2; pfam13538 585054011178 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 585054011179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054011180 motif II; other site 585054011181 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 585054011182 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585054011183 active site 585054011184 DNA binding site [nucleotide binding] 585054011185 Int/Topo IB signature motif; other site 585054011186 hypothetical protein; Provisional; Region: PRK10963 585054011187 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 585054011188 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585054011189 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585054011190 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 585054011191 DKNYY family; Region: DKNYY; pfam13644 585054011192 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 585054011193 putative iron binding site [ion binding]; other site 585054011194 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 585054011195 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 585054011196 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 585054011197 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 585054011198 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 585054011199 domain interfaces; other site 585054011200 active site 585054011201 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 585054011202 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 585054011203 active site 585054011204 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 585054011205 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585054011206 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 585054011207 HemY protein N-terminus; Region: HemY_N; pfam07219 585054011208 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585054011209 Sulfatase; Region: Sulfatase; pfam00884 585054011210 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585054011211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054011212 FeS/SAM binding site; other site 585054011213 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585054011214 putative transport protein YifK; Provisional; Region: PRK10746 585054011215 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 585054011216 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 585054011217 putative common antigen polymerase; Provisional; Region: PRK02975 585054011218 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 585054011219 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585054011220 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 585054011221 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585054011222 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585054011223 inhibitor-cofactor binding pocket; inhibition site 585054011224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054011225 catalytic residue [active] 585054011226 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 585054011227 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585054011228 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585054011229 substrate binding site; other site 585054011230 tetramer interface; other site 585054011231 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 585054011232 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585054011233 NAD binding site [chemical binding]; other site 585054011234 substrate binding site [chemical binding]; other site 585054011235 homodimer interface [polypeptide binding]; other site 585054011236 active site 585054011237 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 585054011238 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585054011239 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585054011240 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585054011241 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 585054011242 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585054011243 active site 585054011244 homodimer interface [polypeptide binding]; other site 585054011245 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 585054011246 Chain length determinant protein; Region: Wzz; pfam02706 585054011247 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 585054011248 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 585054011249 Mg++ binding site [ion binding]; other site 585054011250 putative catalytic motif [active] 585054011251 substrate binding site [chemical binding]; other site 585054011252 transcription termination factor Rho; Provisional; Region: rho; PRK09376 585054011253 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 585054011254 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 585054011255 RNA binding site [nucleotide binding]; other site 585054011256 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 585054011257 multimer interface [polypeptide binding]; other site 585054011258 Walker A motif; other site 585054011259 ATP binding site [chemical binding]; other site 585054011260 Walker B motif; other site 585054011261 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585054011262 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 585054011263 catalytic residues [active] 585054011264 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 585054011265 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585054011266 ATP binding site [chemical binding]; other site 585054011267 Mg++ binding site [ion binding]; other site 585054011268 motif III; other site 585054011269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054011270 nucleotide binding region [chemical binding]; other site 585054011271 ATP-binding site [chemical binding]; other site 585054011272 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 585054011273 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585054011274 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 585054011275 Part of AAA domain; Region: AAA_19; pfam13245 585054011276 Family description; Region: UvrD_C_2; pfam13538 585054011277 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 585054011278 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 585054011279 ketol-acid reductoisomerase; Validated; Region: PRK05225 585054011280 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 585054011281 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585054011282 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585054011283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054011284 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 585054011285 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 585054011286 putative dimerization interface [polypeptide binding]; other site 585054011287 threonine dehydratase; Reviewed; Region: PRK09224 585054011288 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585054011289 tetramer interface [polypeptide binding]; other site 585054011290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054011291 catalytic residue [active] 585054011292 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 585054011293 putative Ile/Val binding site [chemical binding]; other site 585054011294 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 585054011295 putative Ile/Val binding site [chemical binding]; other site 585054011296 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 585054011297 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585054011298 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 585054011299 homodimer interface [polypeptide binding]; other site 585054011300 substrate-cofactor binding pocket; other site 585054011301 catalytic residue [active] 585054011302 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 585054011303 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 585054011304 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585054011305 PYR/PP interface [polypeptide binding]; other site 585054011306 dimer interface [polypeptide binding]; other site 585054011307 TPP binding site [chemical binding]; other site 585054011308 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585054011309 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585054011310 TPP-binding site [chemical binding]; other site 585054011311 dimer interface [polypeptide binding]; other site 585054011312 ilvG operon leader peptide; Provisional; Region: PRK10424 585054011313 putative ATP-dependent protease; Provisional; Region: PRK09862 585054011314 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585054011315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054011316 Walker A motif; other site 585054011317 ATP binding site [chemical binding]; other site 585054011318 Walker B motif; other site 585054011319 arginine finger; other site 585054011320 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 585054011321 hypothetical protein; Provisional; Region: PRK11027 585054011322 transcriptional regulator HdfR; Provisional; Region: PRK03601 585054011323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054011324 LysR substrate binding domain; Region: LysR_substrate; pfam03466 585054011325 dimerization interface [polypeptide binding]; other site 585054011326 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 585054011327 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 585054011328 purine monophosphate binding site [chemical binding]; other site 585054011329 dimer interface [polypeptide binding]; other site 585054011330 putative catalytic residues [active] 585054011331 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 585054011332 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 585054011333 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 585054011334 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 585054011335 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 585054011336 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 585054011337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054011338 active site 585054011339 phosphorylation site [posttranslational modification] 585054011340 intermolecular recognition site; other site 585054011341 dimerization interface [polypeptide binding]; other site 585054011342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054011343 Walker A motif; other site 585054011344 ATP binding site [chemical binding]; other site 585054011345 Walker B motif; other site 585054011346 arginine finger; other site 585054011347 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054011348 sensor protein ZraS; Provisional; Region: PRK10364 585054011349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054011350 dimer interface [polypeptide binding]; other site 585054011351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054011352 ATP binding site [chemical binding]; other site 585054011353 Mg2+ binding site [ion binding]; other site 585054011354 G-X-G motif; other site 585054011355 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585054011356 dimer interface [polypeptide binding]; other site 585054011357 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 585054011358 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585054011359 IHF dimer interface [polypeptide binding]; other site 585054011360 IHF - DNA interface [nucleotide binding]; other site 585054011361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 585054011362 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 585054011363 Active_site [active] 585054011364 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 585054011365 substrate binding site [chemical binding]; other site 585054011366 active site 585054011367 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 585054011368 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 585054011369 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 585054011370 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 585054011371 putative NADH binding site [chemical binding]; other site 585054011372 putative active site [active] 585054011373 nudix motif; other site 585054011374 putative metal binding site [ion binding]; other site 585054011375 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 585054011376 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 585054011377 ThiC-associated domain; Region: ThiC-associated; pfam13667 585054011378 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 585054011379 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 585054011380 thiamine phosphate binding site [chemical binding]; other site 585054011381 active site 585054011382 pyrophosphate binding site [ion binding]; other site 585054011383 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585054011384 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 585054011385 ATP binding site [chemical binding]; other site 585054011386 substrate interface [chemical binding]; other site 585054011387 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 585054011388 thiS-thiF/thiG interaction site; other site 585054011389 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 585054011390 ThiS interaction site; other site 585054011391 putative active site [active] 585054011392 tetramer interface [polypeptide binding]; other site 585054011393 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 585054011394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054011395 FeS/SAM binding site; other site 585054011396 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 585054011397 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 585054011398 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 585054011399 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 585054011400 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 585054011401 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 585054011402 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 585054011403 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585054011404 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 585054011405 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585054011406 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 585054011407 DNA binding site [nucleotide binding] 585054011408 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 585054011409 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 585054011410 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 585054011411 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 585054011412 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585054011413 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 585054011414 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585054011415 RPB3 interaction site [polypeptide binding]; other site 585054011416 RPB1 interaction site [polypeptide binding]; other site 585054011417 RPB11 interaction site [polypeptide binding]; other site 585054011418 RPB10 interaction site [polypeptide binding]; other site 585054011419 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 585054011420 core dimer interface [polypeptide binding]; other site 585054011421 peripheral dimer interface [polypeptide binding]; other site 585054011422 L10 interface [polypeptide binding]; other site 585054011423 L11 interface [polypeptide binding]; other site 585054011424 putative EF-Tu interaction site [polypeptide binding]; other site 585054011425 putative EF-G interaction site [polypeptide binding]; other site 585054011426 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 585054011427 23S rRNA interface [nucleotide binding]; other site 585054011428 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 585054011429 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 585054011430 mRNA/rRNA interface [nucleotide binding]; other site 585054011431 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 585054011432 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 585054011433 23S rRNA interface [nucleotide binding]; other site 585054011434 L7/L12 interface [polypeptide binding]; other site 585054011435 putative thiostrepton binding site; other site 585054011436 L25 interface [polypeptide binding]; other site 585054011437 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 585054011438 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 585054011439 putative homodimer interface [polypeptide binding]; other site 585054011440 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 585054011441 heterodimer interface [polypeptide binding]; other site 585054011442 homodimer interface [polypeptide binding]; other site 585054011443 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 585054011444 elongation factor Tu; Reviewed; Region: PRK00049 585054011445 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585054011446 G1 box; other site 585054011447 GEF interaction site [polypeptide binding]; other site 585054011448 GTP/Mg2+ binding site [chemical binding]; other site 585054011449 Switch I region; other site 585054011450 G2 box; other site 585054011451 G3 box; other site 585054011452 Switch II region; other site 585054011453 G4 box; other site 585054011454 G5 box; other site 585054011455 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585054011456 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585054011457 Antibiotic Binding Site [chemical binding]; other site 585054011458 pantothenate kinase; Provisional; Region: PRK05439 585054011459 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 585054011460 ATP-binding site [chemical binding]; other site 585054011461 CoA-binding site [chemical binding]; other site 585054011462 Mg2+-binding site [ion binding]; other site 585054011463 Biotin operon repressor [Transcription]; Region: BirA; COG1654 585054011464 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 585054011465 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 585054011466 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 585054011467 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 585054011468 FAD binding domain; Region: FAD_binding_4; pfam01565 585054011469 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 585054011470 glutamate racemase; Provisional; Region: PRK00865 585054011471 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 585054011472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585054011473 N-terminal plug; other site 585054011474 ligand-binding site [chemical binding]; other site 585054011475 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 585054011476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054011477 S-adenosylmethionine binding site [chemical binding]; other site 585054011478 hypothetical protein; Provisional; Region: PRK11056 585054011479 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 585054011480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054011481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054011482 metabolite-proton symporter; Region: 2A0106; TIGR00883 585054011483 putative substrate translocation pore; other site 585054011484 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 585054011485 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 585054011486 metal binding site [ion binding]; metal-binding site 585054011487 putative dimer interface [polypeptide binding]; other site 585054011488 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 585054011489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054011490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585054011491 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 585054011492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054011493 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 585054011494 dimerization interface [polypeptide binding]; other site 585054011495 argininosuccinate lyase; Provisional; Region: PRK04833 585054011496 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 585054011497 active sites [active] 585054011498 tetramer interface [polypeptide binding]; other site 585054011499 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 585054011500 nucleotide binding site [chemical binding]; other site 585054011501 N-acetyl-L-glutamate binding site [chemical binding]; other site 585054011502 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 585054011503 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585054011504 acetylornithine deacetylase; Provisional; Region: PRK05111 585054011505 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 585054011506 metal binding site [ion binding]; metal-binding site 585054011507 putative dimer interface [polypeptide binding]; other site 585054011508 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 585054011509 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 585054011510 hypothetical protein; Provisional; Region: PRK10649 585054011511 Sulfatase; Region: Sulfatase; pfam00884 585054011512 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585054011513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054011514 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585054011515 active site 585054011516 P-loop; other site 585054011517 phosphorylation site [posttranslational modification] 585054011518 pyruvate formate lyase II activase; Provisional; Region: PRK10076 585054011519 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 585054011520 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585054011521 dimer interface [polypeptide binding]; other site 585054011522 active site 585054011523 glycine loop; other site 585054011524 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585054011525 active site 585054011526 P-loop; other site 585054011527 phosphorylation site [posttranslational modification] 585054011528 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 585054011529 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585054011530 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585054011531 dimerization domain swap beta strand [polypeptide binding]; other site 585054011532 regulatory protein interface [polypeptide binding]; other site 585054011533 active site 585054011534 regulatory phosphorylation site [posttranslational modification]; other site 585054011535 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585054011536 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585054011537 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585054011538 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585054011539 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054011540 active site 585054011541 phosphorylation site [posttranslational modification] 585054011542 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585054011543 active site 585054011544 intersubunit interactions; other site 585054011545 catalytic residue [active] 585054011546 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585054011547 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 585054011548 dimer interface [polypeptide binding]; other site 585054011549 active site 585054011550 metal binding site [ion binding]; metal-binding site 585054011551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 585054011552 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585054011553 EamA-like transporter family; Region: EamA; pfam00892 585054011554 EamA-like transporter family; Region: EamA; pfam00892 585054011555 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 585054011556 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 585054011557 heme binding site [chemical binding]; other site 585054011558 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 585054011559 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 585054011560 FAD binding site [chemical binding]; other site 585054011561 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585054011562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054011563 DNA-binding site [nucleotide binding]; DNA binding site 585054011564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054011565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054011566 homodimer interface [polypeptide binding]; other site 585054011567 catalytic residue [active] 585054011568 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 585054011569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 585054011570 active site 585054011571 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054011572 dimer interface [polypeptide binding]; other site 585054011573 substrate binding site [chemical binding]; other site 585054011574 catalytic residues [active] 585054011575 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 585054011576 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 585054011577 dimer interface [polypeptide binding]; other site 585054011578 active site 585054011579 glycine-pyridoxal phosphate binding site [chemical binding]; other site 585054011580 folate binding site [chemical binding]; other site 585054011581 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; regulatory protein, LysR family (fragment) 585054011582 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7559336; Product type pr : regulator; LysR-type regulator 585054011583 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 585054011584 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 585054011585 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 585054011586 active site 585054011587 metal binding site [ion binding]; metal-binding site 585054011588 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585054011589 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 585054011590 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585054011591 putative catalytic residues [active] 585054011592 putative nucleotide binding site [chemical binding]; other site 585054011593 putative aspartate binding site [chemical binding]; other site 585054011594 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 585054011595 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585054011596 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585054011597 cystathionine gamma-synthase; Provisional; Region: PRK08045 585054011598 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585054011599 homodimer interface [polypeptide binding]; other site 585054011600 substrate-cofactor binding pocket; other site 585054011601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054011602 catalytic residue [active] 585054011603 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 585054011604 dimerization interface [polypeptide binding]; other site 585054011605 DNA binding site [nucleotide binding] 585054011606 corepressor binding sites; other site 585054011607 hypothetical protein; Provisional; Region: PRK10030 585054011608 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 585054011609 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 585054011610 primosome assembly protein PriA; Validated; Region: PRK05580 585054011611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054011612 ATP binding site [chemical binding]; other site 585054011613 putative Mg++ binding site [ion binding]; other site 585054011614 helicase superfamily c-terminal domain; Region: HELICc; smart00490 585054011615 ATP-binding site [chemical binding]; other site 585054011616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054011617 DNA binding site [nucleotide binding] 585054011618 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 585054011619 domain linker motif; other site 585054011620 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 585054011621 dimerization interface [polypeptide binding]; other site 585054011622 ligand binding site [chemical binding]; other site 585054011623 cell division protein FtsN; Region: ftsN; TIGR02223 585054011624 essential cell division protein FtsN; Provisional; Region: PRK10927 585054011625 Sporulation related domain; Region: SPOR; cl10051 585054011626 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 585054011627 active site 585054011628 HslU subunit interaction site [polypeptide binding]; other site 585054011629 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 585054011630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054011631 Walker A motif; other site 585054011632 ATP binding site [chemical binding]; other site 585054011633 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 585054011634 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585054011635 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 585054011636 UbiA prenyltransferase family; Region: UbiA; pfam01040 585054011637 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 585054011638 septal ring assembly protein ZapB; Provisional; Region: PRK15422 585054011639 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585054011640 amphipathic channel; other site 585054011641 Asn-Pro-Ala signature motifs; other site 585054011642 glycerol kinase; Provisional; Region: glpK; PRK00047 585054011643 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 585054011644 N- and C-terminal domain interface [polypeptide binding]; other site 585054011645 active site 585054011646 MgATP binding site [chemical binding]; other site 585054011647 catalytic site [active] 585054011648 metal binding site [ion binding]; metal-binding site 585054011649 glycerol binding site [chemical binding]; other site 585054011650 homotetramer interface [polypeptide binding]; other site 585054011651 homodimer interface [polypeptide binding]; other site 585054011652 FBP binding site [chemical binding]; other site 585054011653 protein IIAGlc interface [polypeptide binding]; other site 585054011654 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585054011655 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585054011656 putative active site [active] 585054011657 ferredoxin-NADP reductase; Provisional; Region: PRK10926 585054011658 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 585054011659 FAD binding pocket [chemical binding]; other site 585054011660 FAD binding motif [chemical binding]; other site 585054011661 phosphate binding motif [ion binding]; other site 585054011662 beta-alpha-beta structure motif; other site 585054011663 NAD binding pocket [chemical binding]; other site 585054011664 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585054011665 Ligand Binding Site [chemical binding]; other site 585054011666 hypothetical protein; Provisional; Region: PRK09981 585054011667 Predicted membrane protein [Function unknown]; Region: COG3152 585054011668 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 585054011669 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 585054011670 triosephosphate isomerase; Provisional; Region: PRK14567 585054011671 substrate binding site [chemical binding]; other site 585054011672 dimer interface [polypeptide binding]; other site 585054011673 catalytic triad [active] 585054011674 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 585054011675 sulfate transporter subunit; Provisional; Region: PRK10752 585054011676 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585054011677 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 585054011678 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 585054011679 active site 585054011680 ADP/pyrophosphate binding site [chemical binding]; other site 585054011681 dimerization interface [polypeptide binding]; other site 585054011682 allosteric effector site; other site 585054011683 fructose-1,6-bisphosphate binding site; other site 585054011684 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 585054011685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 585054011686 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585054011687 dimer interface [polypeptide binding]; other site 585054011688 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 585054011689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054011690 active site 585054011691 intermolecular recognition site; other site 585054011692 dimerization interface [polypeptide binding]; other site 585054011693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054011694 DNA binding site [nucleotide binding] 585054011695 two-component sensor protein; Provisional; Region: cpxA; PRK09470 585054011696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054011697 dimerization interface [polypeptide binding]; other site 585054011698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054011699 dimer interface [polypeptide binding]; other site 585054011700 phosphorylation site [posttranslational modification] 585054011701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054011702 ATP binding site [chemical binding]; other site 585054011703 Mg2+ binding site [ion binding]; other site 585054011704 G-X-G motif; other site 585054011705 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 585054011706 MOSC domain; Region: MOSC; pfam03473 585054011707 3-alpha domain; Region: 3-alpha; pfam03475 585054011708 superoxide dismutase; Provisional; Region: PRK10925 585054011709 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585054011710 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585054011711 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 585054011712 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 585054011713 transcriptional activator RhaR; Provisional; Region: PRK13502 585054011714 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585054011715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054011716 transcriptional activator RhaS; Provisional; Region: PRK13503 585054011717 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585054011718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054011719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054011720 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 585054011721 N- and C-terminal domain interface [polypeptide binding]; other site 585054011722 active site 585054011723 putative catalytic site [active] 585054011724 metal binding site [ion binding]; metal-binding site 585054011725 ATP binding site [chemical binding]; other site 585054011726 rhamnulokinase; Provisional; Region: rhaB; PRK10640 585054011727 carbohydrate binding site [chemical binding]; other site 585054011728 L-rhamnose isomerase; Provisional; Region: PRK01076 585054011729 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 585054011730 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585054011731 intersubunit interface [polypeptide binding]; other site 585054011732 active site 585054011733 Zn2+ binding site [ion binding]; other site 585054011734 lactaldehyde reductase; Region: lactal_redase; TIGR02638 585054011735 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585054011736 dimer interface [polypeptide binding]; other site 585054011737 active site 585054011738 metal binding site [ion binding]; metal-binding site 585054011739 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 585054011740 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054011741 active site 585054011742 phosphorylation site [posttranslational modification] 585054011743 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 585054011744 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585054011745 active site 585054011746 P-loop; other site 585054011747 phosphorylation site [posttranslational modification] 585054011748 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585054011749 putative peptidase; Provisional; Region: PRK09864 585054011750 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 585054011751 oligomer interface [polypeptide binding]; other site 585054011752 active site 585054011753 metal binding site [ion binding]; metal-binding site 585054011754 putative frv operon regulatory protein; Provisional; Region: PRK09863 585054011755 HTH domain; Region: HTH_11; pfam08279 585054011756 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054011757 active site 585054011758 phosphorylation site [posttranslational modification] 585054011759 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585054011760 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 585054011761 Invasin, domain 3; Region: Invasin_D3; pfam09134 585054011762 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 585054011763 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 585054011764 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 585054011765 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 585054011766 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 585054011767 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 585054011768 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585054011769 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585054011770 [4Fe-4S] binding site [ion binding]; other site 585054011771 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585054011772 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585054011773 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585054011774 molybdopterin cofactor binding site; other site 585054011775 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585054011776 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585054011777 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 585054011778 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585054011779 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 585054011780 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 585054011781 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 585054011782 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein, transcriptional regulator (partial) 585054011783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054011784 Coenzyme A binding pocket [chemical binding]; other site 585054011785 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 585054011786 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 585054011787 putative active site [active] 585054011788 dimerization interface [polypeptide binding]; other site 585054011789 putative tRNAtyr binding site [nucleotide binding]; other site 585054011790 hypothetical protein; Reviewed; Region: PRK01637 585054011791 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585054011792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054011793 motif II; other site 585054011794 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 585054011795 Sulfatase; Region: Sulfatase; cl17466 585054011796 coproporphyrinogen III oxidase; Validated; Region: PRK08208 585054011797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054011798 FeS/SAM binding site; other site 585054011799 HemN C-terminal domain; Region: HemN_C; pfam06969 585054011800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054011801 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 585054011802 active site 585054011803 motif I; other site 585054011804 motif II; other site 585054011805 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585054011806 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 585054011807 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 585054011808 G1 box; other site 585054011809 putative GEF interaction site [polypeptide binding]; other site 585054011810 GTP/Mg2+ binding site [chemical binding]; other site 585054011811 Switch I region; other site 585054011812 G2 box; other site 585054011813 G3 box; other site 585054011814 Switch II region; other site 585054011815 G4 box; other site 585054011816 G5 box; other site 585054011817 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 585054011818 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 585054011819 glutamine synthetase; Provisional; Region: glnA; PRK09469 585054011820 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 585054011821 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585054011822 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 585054011823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585054011824 putative active site [active] 585054011825 heme pocket [chemical binding]; other site 585054011826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054011827 dimer interface [polypeptide binding]; other site 585054011828 phosphorylation site [posttranslational modification] 585054011829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054011830 ATP binding site [chemical binding]; other site 585054011831 Mg2+ binding site [ion binding]; other site 585054011832 G-X-G motif; other site 585054011833 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 585054011834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054011835 active site 585054011836 phosphorylation site [posttranslational modification] 585054011837 intermolecular recognition site; other site 585054011838 dimerization interface [polypeptide binding]; other site 585054011839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054011840 Walker A motif; other site 585054011841 ATP binding site [chemical binding]; other site 585054011842 Walker B motif; other site 585054011843 arginine finger; other site 585054011844 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054011845 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 585054011846 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585054011847 NAD(P) binding site [chemical binding]; other site 585054011848 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585054011849 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585054011850 substrate-cofactor binding pocket; other site 585054011851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054011852 catalytic residue [active] 585054011853 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 585054011854 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 585054011855 NADP binding site [chemical binding]; other site 585054011856 homopentamer interface [polypeptide binding]; other site 585054011857 substrate binding site [chemical binding]; other site 585054011858 active site 585054011859 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585054011860 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585054011861 putative active site [active] 585054011862 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585054011863 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585054011864 putative active site [active] 585054011865 O-antigen ligase RfaL; Provisional; Region: PRK15487 585054011866 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 585054011867 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 585054011868 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585054011869 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 585054011870 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 585054011871 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 585054011872 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585054011873 Ligand binding site; other site 585054011874 metal-binding site 585054011875 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585054011876 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585054011877 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585054011878 Ligand binding site; other site 585054011879 metal-binding site 585054011880 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585054011881 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of UDP-D-galactose:(glucosyl) lipopolysaccharide-1, 6-D-galactosyltransferase (part 2) 585054011882 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 585054011883 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054011884 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of UDP-D-galactose:(glucosyl) lipopolysaccharide-1, 6-D-galactosyltransferase (part 1) 585054011885 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 585054011886 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 585054011887 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585054011888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585054011889 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 585054011890 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585054011891 putative active site [active] 585054011892 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 585054011893 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 585054011894 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585054011895 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 585054011896 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 585054011897 active site 585054011898 (T/H)XGH motif; other site 585054011899 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 585054011900 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 585054011901 DNA binding site [nucleotide binding] 585054011902 catalytic residue [active] 585054011903 H2TH interface [polypeptide binding]; other site 585054011904 putative catalytic residues [active] 585054011905 turnover-facilitating residue; other site 585054011906 intercalation triad [nucleotide binding]; other site 585054011907 8OG recognition residue [nucleotide binding]; other site 585054011908 putative reading head residues; other site 585054011909 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585054011910 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585054011911 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 585054011912 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 585054011913 hypothetical protein; Reviewed; Region: PRK00024 585054011914 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585054011915 MPN+ (JAMM) motif; other site 585054011916 Zinc-binding site [ion binding]; other site 585054011917 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 585054011918 Flavoprotein; Region: Flavoprotein; pfam02441 585054011919 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 585054011920 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585054011921 trimer interface [polypeptide binding]; other site 585054011922 active site 585054011923 division inhibitor protein; Provisional; Region: slmA; PRK09480 585054011924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054011925 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 585054011926 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 585054011927 putative active site [active] 585054011928 putative NTP binding site [chemical binding]; other site 585054011929 putative nucleic acid binding site [nucleotide binding]; other site 585054011930 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585054011931 active site 585054011932 ribonuclease PH; Reviewed; Region: rph; PRK00173 585054011933 Ribonuclease PH; Region: RNase_PH_bact; cd11362 585054011934 hexamer interface [polypeptide binding]; other site 585054011935 active site 585054011936 hypothetical protein; Provisional; Region: PRK11820 585054011937 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 585054011938 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 585054011939 Predicted membrane protein [Function unknown]; Region: COG2860 585054011940 UPF0126 domain; Region: UPF0126; pfam03458 585054011941 UPF0126 domain; Region: UPF0126; pfam03458 585054011942 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA ligase, NAD(+)-dependent (part 2) 585054011943 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA ligase, NAD(+)-dependent (part 1) 585054011944 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 585054011945 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 585054011946 catalytic site [active] 585054011947 G-X2-G-X-G-K; other site 585054011948 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 585054011949 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 585054011950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585054011951 Zn2+ binding site [ion binding]; other site 585054011952 Mg2+ binding site [ion binding]; other site 585054011953 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585054011954 synthetase active site [active] 585054011955 NTP binding site [chemical binding]; other site 585054011956 metal binding site [ion binding]; metal-binding site 585054011957 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585054011958 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585054011959 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 585054011960 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585054011961 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 585054011962 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 585054011963 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 585054011964 generic binding surface II; other site 585054011965 ssDNA binding site; other site 585054011966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585054011967 ATP binding site [chemical binding]; other site 585054011968 putative Mg++ binding site [ion binding]; other site 585054011969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585054011970 nucleotide binding region [chemical binding]; other site 585054011971 ATP-binding site [chemical binding]; other site 585054011972 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 585054011973 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 585054011974 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 585054011975 AsmA family; Region: AsmA; pfam05170 585054011976 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585054011977 putative alpha-glucosidase; Provisional; Region: PRK10658 585054011978 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585054011979 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 585054011980 active site 585054011981 homotrimer interface [polypeptide binding]; other site 585054011982 catalytic site [active] 585054011983 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 585054011984 putative transporter; Provisional; Region: PRK11462 585054011985 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 585054011986 Virulence protein [General function prediction only]; Region: COG3943 585054011987 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 585054011988 EamA-like transporter family; Region: EamA; pfam00892 585054011989 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585054011990 EamA-like transporter family; Region: EamA; pfam00892 585054011991 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585054011992 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054011993 DNA binding site [nucleotide binding] 585054011994 domain linker motif; other site 585054011995 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 585054011996 ligand binding site [chemical binding]; other site 585054011997 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585054011998 active site 585054011999 P-loop; other site 585054012000 phosphorylation site [posttranslational modification] 585054012001 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 585054012002 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 585054012003 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 585054012004 beta-galactosidase; Region: BGL; TIGR03356 585054012005 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585054012006 methionine cluster; other site 585054012007 active site 585054012008 phosphorylation site [posttranslational modification] 585054012009 metal binding site [ion binding]; metal-binding site 585054012010 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585054012011 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 585054012012 cryptic adenine deaminase; Provisional; Region: PRK10027 585054012013 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585054012014 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 585054012015 active site 585054012016 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 585054012017 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 585054012018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012019 putative substrate translocation pore; other site 585054012020 regulatory protein UhpC; Provisional; Region: PRK11663 585054012021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012022 putative substrate translocation pore; other site 585054012023 sensory histidine kinase UhpB; Provisional; Region: PRK11644 585054012024 MASE1; Region: MASE1; pfam05231 585054012025 Histidine kinase; Region: HisKA_3; pfam07730 585054012026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054012027 ATP binding site [chemical binding]; other site 585054012028 Mg2+ binding site [ion binding]; other site 585054012029 G-X-G motif; other site 585054012030 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 585054012031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054012032 active site 585054012033 phosphorylation site [posttranslational modification] 585054012034 intermolecular recognition site; other site 585054012035 dimerization interface [polypeptide binding]; other site 585054012036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054012037 DNA binding residues [nucleotide binding] 585054012038 dimerization interface [polypeptide binding]; other site 585054012039 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 585054012040 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585054012041 putative valine binding site [chemical binding]; other site 585054012042 dimer interface [polypeptide binding]; other site 585054012043 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 585054012044 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585054012045 PYR/PP interface [polypeptide binding]; other site 585054012046 dimer interface [polypeptide binding]; other site 585054012047 TPP binding site [chemical binding]; other site 585054012048 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585054012049 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585054012050 TPP-binding site [chemical binding]; other site 585054012051 dimer interface [polypeptide binding]; other site 585054012052 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 585054012053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012054 putative substrate translocation pore; other site 585054012055 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 585054012056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054012057 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585054012058 dimerization interface [polypeptide binding]; other site 585054012059 substrate binding pocket [chemical binding]; other site 585054012060 permease DsdX; Provisional; Region: PRK09921 585054012061 gluconate transporter; Region: gntP; TIGR00791 585054012062 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 585054012063 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 585054012064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585054012065 catalytic residue [active] 585054012066 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585054012067 Domain of unknown function (DUF202); Region: DUF202; pfam02656 585054012068 Predicted membrane protein [Function unknown]; Region: COG2149 585054012069 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585054012070 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 585054012071 NAD binding site [chemical binding]; other site 585054012072 sugar binding site [chemical binding]; other site 585054012073 divalent metal binding site [ion binding]; other site 585054012074 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 585054012075 dimer interface [polypeptide binding]; other site 585054012076 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 585054012077 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585054012078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054012079 active site turn [active] 585054012080 phosphorylation site [posttranslational modification] 585054012081 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585054012082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054012083 DNA-binding site [nucleotide binding]; DNA binding site 585054012084 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 585054012085 putative transporter; Validated; Region: PRK03818 585054012086 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585054012087 TrkA-C domain; Region: TrkA_C; pfam02080 585054012088 TrkA-C domain; Region: TrkA_C; pfam02080 585054012089 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585054012090 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585054012091 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585054012092 putative dimer interface [polypeptide binding]; other site 585054012093 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585054012094 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585054012095 putative dimer interface [polypeptide binding]; other site 585054012096 hypothetical protein; Provisional; Region: PRK11616 585054012097 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 585054012098 putative oxidoreductase; Provisional; Region: PRK11445 585054012099 hypothetical protein; Provisional; Region: PRK07236 585054012100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012101 D-galactonate transporter; Region: 2A0114; TIGR00893 585054012102 putative substrate translocation pore; other site 585054012103 galactonate dehydratase; Provisional; Region: PRK14017 585054012104 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 585054012105 putative active site pocket [active] 585054012106 putative metal binding site [ion binding]; other site 585054012107 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585054012108 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585054012109 active site 585054012110 intersubunit interface [polypeptide binding]; other site 585054012111 catalytic residue [active] 585054012112 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585054012113 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585054012114 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585054012115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054012116 DNA-binding site [nucleotide binding]; DNA binding site 585054012117 FCD domain; Region: FCD; pfam07729 585054012118 hypothetical protein; Provisional; Region: PRK10215 585054012119 sugar phosphate phosphatase; Provisional; Region: PRK10513 585054012120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054012121 active site 585054012122 motif I; other site 585054012123 motif II; other site 585054012124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054012125 hypothetical protein; Provisional; Region: PRK11426 585054012126 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 585054012127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054012128 Mg2+ binding site [ion binding]; other site 585054012129 G-X-G motif; other site 585054012130 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585054012131 anchoring element; other site 585054012132 dimer interface [polypeptide binding]; other site 585054012133 ATP binding site [chemical binding]; other site 585054012134 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 585054012135 active site 585054012136 putative metal-binding site [ion binding]; other site 585054012137 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585054012138 recF protein; Region: recf; TIGR00611 585054012139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054012140 Walker A/P-loop; other site 585054012141 ATP binding site [chemical binding]; other site 585054012142 Q-loop/lid; other site 585054012143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054012144 ABC transporter signature motif; other site 585054012145 Walker B; other site 585054012146 D-loop; other site 585054012147 H-loop/switch region; other site 585054012148 DNA polymerase III subunit beta; Validated; Region: PRK05643 585054012149 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 585054012150 putative DNA binding surface [nucleotide binding]; other site 585054012151 dimer interface [polypeptide binding]; other site 585054012152 beta-clamp/clamp loader binding surface; other site 585054012153 beta-clamp/translesion DNA polymerase binding surface; other site 585054012154 DnaA N-terminal domain; Region: DnaA_N; pfam11638 585054012155 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 585054012156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054012157 Walker A motif; other site 585054012158 ATP binding site [chemical binding]; other site 585054012159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585054012160 Walker B motif; other site 585054012161 arginine finger; other site 585054012162 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 585054012163 DnaA box-binding interface [nucleotide binding]; other site 585054012164 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 585054012165 ribonuclease P; Reviewed; Region: rnpA; PRK01732 585054012166 hypothetical protein; Validated; Region: PRK00041 585054012167 membrane protein insertase; Provisional; Region: PRK01318 585054012168 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 585054012169 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 585054012170 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 585054012171 trmE is a tRNA modification GTPase; Region: trmE; cd04164 585054012172 G1 box; other site 585054012173 GTP/Mg2+ binding site [chemical binding]; other site 585054012174 Switch I region; other site 585054012175 G2 box; other site 585054012176 Switch II region; other site 585054012177 G3 box; other site 585054012178 G4 box; other site 585054012179 G5 box; other site 585054012180 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 585054012181 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 585054012182 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 585054012183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585054012184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585054012185 catalytic residue [active] 585054012186 tryptophan permease TnaB; Provisional; Region: PRK09664 585054012187 aromatic amino acid transport protein; Region: araaP; TIGR00837 585054012188 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 585054012189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012190 putative substrate translocation pore; other site 585054012191 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 585054012192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054012193 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585054012194 substrate binding pocket [chemical binding]; other site 585054012195 dimerization interface [polypeptide binding]; other site 585054012196 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 585054012197 Predicted flavoprotein [General function prediction only]; Region: COG0431 585054012198 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585054012199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054012200 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585054012201 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 585054012202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054012203 active site 585054012204 motif I; other site 585054012205 motif II; other site 585054012206 putative inner membrane protein; Provisional; Region: PRK09823 585054012207 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 585054012208 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585054012209 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585054012210 active site 585054012211 trimer interface [polypeptide binding]; other site 585054012212 allosteric site; other site 585054012213 active site lid [active] 585054012214 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585054012215 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 585054012216 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 585054012217 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585054012218 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585054012219 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585054012220 trimer interface; other site 585054012221 sugar binding site [chemical binding]; other site 585054012222 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 585054012223 beta-galactosidase; Region: BGL; TIGR03356 585054012224 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 585054012225 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054012226 active site turn [active] 585054012227 phosphorylation site [posttranslational modification] 585054012228 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585054012229 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585054012230 HPr interaction site; other site 585054012231 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585054012232 active site 585054012233 phosphorylation site [posttranslational modification] 585054012234 transcriptional antiterminator BglG; Provisional; Region: PRK09772 585054012235 CAT RNA binding domain; Region: CAT_RBD; pfam03123 585054012236 PRD domain; Region: PRD; pfam00874 585054012237 PRD domain; Region: PRD; pfam00874 585054012238 transcriptional regulator PhoU; Provisional; Region: PRK11115 585054012239 PhoU domain; Region: PhoU; pfam01895 585054012240 PhoU domain; Region: PhoU; pfam01895 585054012241 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 585054012242 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 585054012243 Walker A/P-loop; other site 585054012244 ATP binding site [chemical binding]; other site 585054012245 Q-loop/lid; other site 585054012246 ABC transporter signature motif; other site 585054012247 Walker B; other site 585054012248 D-loop; other site 585054012249 H-loop/switch region; other site 585054012250 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 585054012251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054012252 dimer interface [polypeptide binding]; other site 585054012253 conserved gate region; other site 585054012254 putative PBP binding loops; other site 585054012255 ABC-ATPase subunit interface; other site 585054012256 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 585054012257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054012258 dimer interface [polypeptide binding]; other site 585054012259 conserved gate region; other site 585054012260 putative PBP binding loops; other site 585054012261 ABC-ATPase subunit interface; other site 585054012262 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585054012263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054012264 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 585054012265 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 585054012266 glutaminase active site [active] 585054012267 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585054012268 dimer interface [polypeptide binding]; other site 585054012269 active site 585054012270 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585054012271 dimer interface [polypeptide binding]; other site 585054012272 active site 585054012273 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 585054012274 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 585054012275 Substrate binding site; other site 585054012276 Mg++ binding site; other site 585054012277 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 585054012278 active site 585054012279 substrate binding site [chemical binding]; other site 585054012280 CoA binding site [chemical binding]; other site 585054012281 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585054012282 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 585054012283 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 585054012284 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 585054012285 gamma subunit interface [polypeptide binding]; other site 585054012286 epsilon subunit interface [polypeptide binding]; other site 585054012287 LBP interface [polypeptide binding]; other site 585054012288 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 585054012289 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585054012290 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 585054012291 alpha subunit interaction interface [polypeptide binding]; other site 585054012292 Walker A motif; other site 585054012293 ATP binding site [chemical binding]; other site 585054012294 Walker B motif; other site 585054012295 inhibitor binding site; inhibition site 585054012296 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585054012297 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 585054012298 core domain interface [polypeptide binding]; other site 585054012299 delta subunit interface [polypeptide binding]; other site 585054012300 epsilon subunit interface [polypeptide binding]; other site 585054012301 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 585054012302 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585054012303 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 585054012304 beta subunit interaction interface [polypeptide binding]; other site 585054012305 Walker A motif; other site 585054012306 ATP binding site [chemical binding]; other site 585054012307 Walker B motif; other site 585054012308 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585054012309 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 585054012310 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 585054012311 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 585054012312 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 585054012313 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 585054012314 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 585054012315 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 585054012316 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 585054012317 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 585054012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054012319 S-adenosylmethionine binding site [chemical binding]; other site 585054012320 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 585054012321 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 585054012322 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 585054012323 FMN-binding protein MioC; Provisional; Region: PRK09004 585054012324 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 585054012325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054012326 putative DNA binding site [nucleotide binding]; other site 585054012327 putative Zn2+ binding site [ion binding]; other site 585054012328 AsnC family; Region: AsnC_trans_reg; pfam01037 585054012329 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 585054012330 dimer interface [polypeptide binding]; other site 585054012331 active site 585054012332 hypothetical protein; Provisional; Region: yieM; PRK10997 585054012333 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585054012334 metal ion-dependent adhesion site (MIDAS); other site 585054012335 regulatory ATPase RavA; Provisional; Region: PRK13531 585054012336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054012337 Walker A motif; other site 585054012338 ATP binding site [chemical binding]; other site 585054012339 Walker B motif; other site 585054012340 arginine finger; other site 585054012341 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 585054012342 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 585054012343 potassium uptake protein; Region: kup; TIGR00794 585054012344 D-ribose pyranase; Provisional; Region: PRK11797 585054012345 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 585054012346 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585054012347 Walker A/P-loop; other site 585054012348 ATP binding site [chemical binding]; other site 585054012349 Q-loop/lid; other site 585054012350 ABC transporter signature motif; other site 585054012351 Walker B; other site 585054012352 D-loop; other site 585054012353 H-loop/switch region; other site 585054012354 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054012355 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054012356 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054012357 TM-ABC transporter signature motif; other site 585054012358 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 585054012359 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 585054012360 ligand binding site [chemical binding]; other site 585054012361 dimerization interface [polypeptide binding]; other site 585054012362 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585054012363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585054012364 substrate binding site [chemical binding]; other site 585054012365 dimer interface [polypeptide binding]; other site 585054012366 ATP binding site [chemical binding]; other site 585054012367 transcriptional repressor RbsR; Provisional; Region: PRK10423 585054012368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054012369 DNA binding site [nucleotide binding] 585054012370 domain linker motif; other site 585054012371 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585054012372 dimerization interface [polypeptide binding]; other site 585054012373 ligand binding site [chemical binding]; other site 585054012374 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585054012375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054012376 DNA-binding site [nucleotide binding]; DNA binding site 585054012377 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054012378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585054012379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054012380 Coenzyme A binding pocket [chemical binding]; other site 585054012381 homoserine O-succinyltransferase; Provisional; Region: PRK05368 585054012382 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 585054012383 proposed active site lysine [active] 585054012384 conserved cys residue [active] 585054012385 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 585054012386 malate synthase A; Region: malate_syn_A; TIGR01344 585054012387 active site 585054012388 isocitrate lyase; Provisional; Region: PRK15063 585054012389 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585054012390 tetramer interface [polypeptide binding]; other site 585054012391 active site 585054012392 Mg2+/Mn2+ binding site [ion binding]; other site 585054012393 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 585054012394 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 585054012395 DNA cytosine methylase; Provisional; Region: PRK10458 585054012396 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585054012397 cofactor binding site; other site 585054012398 DNA binding site [nucleotide binding] 585054012399 substrate interaction site [chemical binding]; other site 585054012400 transcriptional repressor IclR; Provisional; Region: PRK11569 585054012401 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585054012402 Bacterial transcriptional regulator; Region: IclR; pfam01614 585054012403 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 585054012404 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 585054012405 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 585054012406 substrate binding pocket [chemical binding]; other site 585054012407 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 585054012408 B12 binding site [chemical binding]; other site 585054012409 cobalt ligand [ion binding]; other site 585054012410 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 585054012411 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 585054012412 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585054012413 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585054012414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 585054012415 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585054012416 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585054012417 putative NAD(P) binding site [chemical binding]; other site 585054012418 catalytic Zn binding site [ion binding]; other site 585054012419 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 585054012420 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585054012421 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585054012422 active site 585054012423 phosphorylation site [posttranslational modification] 585054012424 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585054012425 active pocket/dimerization site; other site 585054012426 active site 585054012427 phosphorylation site [posttranslational modification] 585054012428 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 585054012429 classical (c) SDRs; Region: SDR_c; cd05233 585054012430 NAD(P) binding site [chemical binding]; other site 585054012431 active site 585054012432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054012433 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585054012434 putative DNA binding site [nucleotide binding]; other site 585054012435 putative Zn2+ binding site [ion binding]; other site 585054012436 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585054012437 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 585054012438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585054012439 RNA binding surface [nucleotide binding]; other site 585054012440 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 585054012441 probable active site [active] 585054012442 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054012443 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 585054012444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585054012445 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 23S rRNA pseudouridine synthase (partial) 585054012446 hypothetical protein; Provisional; Region: PRK10515 585054012447 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585054012448 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585054012449 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 585054012450 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585054012451 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 585054012452 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 585054012453 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585054012454 Phage Tail Collar Domain; Region: Collar; pfam07484 585054012455 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 585054012456 Baseplate J-like protein; Region: Baseplate_J; cl01294 585054012457 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 585054012458 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585054012459 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 585054012460 Phage protein D [General function prediction only]; Region: COG3500 585054012461 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 585054012462 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 585054012463 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 585054012464 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 585054012465 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585054012466 Phage tail tube protein FII [General function prediction only]; Region: COG3498 585054012467 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 585054012468 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 585054012469 Gp37 protein; Region: Gp37; pfam09646 585054012470 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054012471 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054012472 catalytic residue [active] 585054012473 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 585054012474 Mor transcription activator family; Region: Mor; pfam08765 585054012475 Zeta toxin; Region: Zeta_toxin; pfam06414 585054012476 aspartate kinase III; Validated; Region: PRK09084 585054012477 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 585054012478 nucleotide binding site [chemical binding]; other site 585054012479 substrate binding site [chemical binding]; other site 585054012480 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585054012481 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 585054012482 dimer interface [polypeptide binding]; other site 585054012483 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 585054012484 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 585054012485 active site 585054012486 dimer interface [polypeptide binding]; other site 585054012487 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 585054012488 dimer interface [polypeptide binding]; other site 585054012489 active site 585054012490 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585054012491 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585054012492 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585054012493 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 585054012494 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 585054012495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012496 putative substrate translocation pore; other site 585054012497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012498 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585054012499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054012500 dimer interface [polypeptide binding]; other site 585054012501 conserved gate region; other site 585054012502 putative PBP binding loops; other site 585054012503 ABC-ATPase subunit interface; other site 585054012504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585054012505 dimer interface [polypeptide binding]; other site 585054012506 conserved gate region; other site 585054012507 putative PBP binding loops; other site 585054012508 ABC-ATPase subunit interface; other site 585054012509 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 585054012510 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585054012511 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 585054012512 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585054012513 Walker A/P-loop; other site 585054012514 ATP binding site [chemical binding]; other site 585054012515 Q-loop/lid; other site 585054012516 ABC transporter signature motif; other site 585054012517 Walker B; other site 585054012518 D-loop; other site 585054012519 H-loop/switch region; other site 585054012520 TOBE domain; Region: TOBE_2; pfam08402 585054012521 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585054012522 trimer interface; other site 585054012523 sugar binding site [chemical binding]; other site 585054012524 maltose regulon periplasmic protein; Provisional; Region: PRK10564 585054012525 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 585054012526 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 585054012527 UbiA prenyltransferase family; Region: UbiA; pfam01040 585054012528 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 585054012529 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 585054012530 putative acyl-acceptor binding pocket; other site 585054012531 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585054012532 LexA repressor; Validated; Region: PRK00215 585054012533 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585054012534 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054012535 Catalytic site [active] 585054012536 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 585054012537 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 585054012538 hypothetical protein; Provisional; Region: PRK10428 585054012539 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585054012540 metal binding site 2 [ion binding]; metal-binding site 585054012541 putative DNA binding helix; other site 585054012542 metal binding site 1 [ion binding]; metal-binding site 585054012543 dimer interface [polypeptide binding]; other site 585054012544 structural Zn2+ binding site [ion binding]; other site 585054012545 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 585054012546 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585054012547 FMN binding site [chemical binding]; other site 585054012548 active site 585054012549 catalytic residues [active] 585054012550 substrate binding site [chemical binding]; other site 585054012551 phage shock protein G; Reviewed; Region: pspG; PRK09459 585054012552 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 585054012553 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 585054012554 NADP binding site [chemical binding]; other site 585054012555 dimer interface [polypeptide binding]; other site 585054012556 replicative DNA helicase; Provisional; Region: PRK08006 585054012557 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585054012558 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585054012559 Walker A motif; other site 585054012560 ATP binding site [chemical binding]; other site 585054012561 Walker B motif; other site 585054012562 DNA binding loops [nucleotide binding] 585054012563 putative lipoprotein; Provisional; Region: PRK10533 585054012564 alanine racemase; Reviewed; Region: alr; PRK00053 585054012565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585054012566 active site 585054012567 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585054012568 substrate binding site [chemical binding]; other site 585054012569 catalytic residues [active] 585054012570 dimer interface [polypeptide binding]; other site 585054012571 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 585054012572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585054012573 active site 585054012574 nucleotide binding site [chemical binding]; other site 585054012575 HIGH motif; other site 585054012576 KMSKS motif; other site 585054012577 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585054012578 AAA domain; Region: AAA_28; pfam13521 585054012579 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585054012580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585054012581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585054012582 homodimer interface [polypeptide binding]; other site 585054012583 catalytic residue [active] 585054012584 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2-oxoglutarate decarboxylase, thiamin-requiring (part 1) 585054012585 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2-oxoglutarate decarboxylase, thiamin-requiring (part 2) 585054012586 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585054012587 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585054012588 E3 interaction surface; other site 585054012589 lipoyl attachment site [posttranslational modification]; other site 585054012590 e3 binding domain; Region: E3_binding; pfam02817 585054012591 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585054012592 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 585054012593 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 585054012594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585054012595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585054012596 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585054012597 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585054012598 CoA-ligase; Region: Ligase_CoA; pfam00549 585054012599 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585054012600 CoA binding domain; Region: CoA_binding; smart00881 585054012601 CoA-ligase; Region: Ligase_CoA; pfam00549 585054012602 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 585054012603 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585054012604 transmembrane helices; other site 585054012605 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 585054012606 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 585054012607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054012608 active site 585054012609 phosphorylation site [posttranslational modification] 585054012610 intermolecular recognition site; other site 585054012611 dimerization interface [polypeptide binding]; other site 585054012612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054012613 Walker A motif; other site 585054012614 ATP binding site [chemical binding]; other site 585054012615 Walker B motif; other site 585054012616 arginine finger; other site 585054012617 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585054012618 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 585054012619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054012620 dimer interface [polypeptide binding]; other site 585054012621 phosphorylation site [posttranslational modification] 585054012622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054012623 ATP binding site [chemical binding]; other site 585054012624 Mg2+ binding site [ion binding]; other site 585054012625 G-X-G motif; other site 585054012626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054012627 active site 585054012628 motif I; other site 585054012629 motif II; other site 585054012630 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 585054012631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 585054012632 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 585054012633 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585054012634 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585054012635 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 585054012636 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585054012637 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585054012638 dimer interface [polypeptide binding]; other site 585054012639 ssDNA binding site [nucleotide binding]; other site 585054012640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585054012641 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 585054012642 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585054012643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054012644 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 585054012645 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 585054012646 DNA binding residues [nucleotide binding] 585054012647 dimer interface [polypeptide binding]; other site 585054012648 [2Fe-2S] cluster binding site [ion binding]; other site 585054012649 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585054012650 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 585054012651 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585054012652 hypothetical protein; Provisional; Region: PRK10220 585054012653 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 585054012654 PhnA protein; Region: PhnA; pfam03831 585054012655 hypothetical protein; Provisional; Region: PRK09866 585054012656 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585054012657 G1 box; other site 585054012658 GTP/Mg2+ binding site [chemical binding]; other site 585054012659 G2 box; other site 585054012660 Switch I region; other site 585054012661 G3 box; other site 585054012662 Switch II region; other site 585054012663 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585054012664 G3 box; other site 585054012665 Switch II region; other site 585054012666 G4 box; other site 585054012667 G5 box; other site 585054012668 YjcZ-like protein; Region: YjcZ; pfam13990 585054012669 proline/glycine betaine transporter; Provisional; Region: PRK10642 585054012670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012671 putative substrate translocation pore; other site 585054012672 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 585054012673 sensor protein BasS/PmrB; Provisional; Region: PRK10755 585054012674 HAMP domain; Region: HAMP; pfam00672 585054012675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054012676 dimer interface [polypeptide binding]; other site 585054012677 phosphorylation site [posttranslational modification] 585054012678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054012679 ATP binding site [chemical binding]; other site 585054012680 Mg2+ binding site [ion binding]; other site 585054012681 G-X-G motif; other site 585054012682 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 585054012683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054012684 active site 585054012685 phosphorylation site [posttranslational modification] 585054012686 intermolecular recognition site; other site 585054012687 dimerization interface [polypeptide binding]; other site 585054012688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054012689 DNA binding site [nucleotide binding] 585054012690 putative metal dependent hydrolase; Provisional; Region: PRK11598 585054012691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054012692 Sulfatase; Region: Sulfatase; pfam00884 585054012693 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585054012694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054012695 hypothetical protein; Provisional; Region: PRK09867 585054012696 fumarate hydratase; Provisional; Region: PRK15389 585054012697 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585054012698 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585054012699 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585054012700 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 585054012701 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 585054012702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054012703 active site 585054012704 phosphorylation site [posttranslational modification] 585054012705 intermolecular recognition site; other site 585054012706 dimerization interface [polypeptide binding]; other site 585054012707 sensory histidine kinase DcuS; Provisional; Region: PRK11086 585054012708 PAS domain; Region: PAS; smart00091 585054012709 putative active site [active] 585054012710 heme pocket [chemical binding]; other site 585054012711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054012712 ATP binding site [chemical binding]; other site 585054012713 Mg2+ binding site [ion binding]; other site 585054012714 G-X-G motif; other site 585054012715 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585054012716 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585054012717 putative [Fe4-S4] binding site [ion binding]; other site 585054012718 putative molybdopterin cofactor binding site [chemical binding]; other site 585054012719 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585054012720 putative molybdopterin cofactor binding site; other site 585054012721 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585054012722 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 585054012723 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 585054012724 ferredoxin-type protein NapF; Region: napF; TIGR00402 585054012725 putative transcriptional regulator; Provisional; Region: PRK11640 585054012726 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 585054012727 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 585054012728 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 585054012729 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 585054012730 DsbD alpha interface [polypeptide binding]; other site 585054012731 catalytic residues [active] 585054012732 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 585054012733 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585054012734 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 585054012735 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 585054012736 Aspartase; Region: Aspartase; cd01357 585054012737 active sites [active] 585054012738 tetramer interface [polypeptide binding]; other site 585054012739 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 585054012740 putative transporter; Provisional; Region: PRK11021 585054012741 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 585054012742 oligomerisation interface [polypeptide binding]; other site 585054012743 mobile loop; other site 585054012744 roof hairpin; other site 585054012745 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 585054012746 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 585054012747 ring oligomerisation interface [polypeptide binding]; other site 585054012748 ATP/Mg binding site [chemical binding]; other site 585054012749 stacking interactions; other site 585054012750 hinge regions; other site 585054012751 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 585054012752 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 585054012753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054012754 FeS/SAM binding site; other site 585054012755 elongation factor P; Validated; Region: PRK00529 585054012756 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585054012757 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585054012758 RNA binding site [nucleotide binding]; other site 585054012759 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585054012760 RNA binding site [nucleotide binding]; other site 585054012761 entericidin A; Provisional; Region: PRK09810 585054012762 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 585054012763 multidrug efflux system protein; Provisional; Region: PRK11431 585054012764 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 585054012765 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 585054012766 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 585054012767 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585054012768 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 585054012769 Iron-sulfur protein interface; other site 585054012770 proximal quinone binding site [chemical binding]; other site 585054012771 C-subunit interface; other site 585054012772 distal quinone binding site; other site 585054012773 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 585054012774 D-subunit interface [polypeptide binding]; other site 585054012775 Iron-sulfur protein interface; other site 585054012776 proximal quinone binding site [chemical binding]; other site 585054012777 distal quinone binding site [chemical binding]; other site 585054012778 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 585054012779 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585054012780 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 585054012781 L-aspartate oxidase; Provisional; Region: PRK06175 585054012782 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585054012783 poxB regulator PoxA; Provisional; Region: PRK09350 585054012784 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585054012785 motif 1; other site 585054012786 dimer interface [polypeptide binding]; other site 585054012787 active site 585054012788 motif 2; other site 585054012789 motif 3; other site 585054012790 inner membrane transporter YjeM; Provisional; Region: PRK15238 585054012791 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 585054012792 putative mechanosensitive channel protein; Provisional; Region: PRK10929 585054012793 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 585054012794 DNA-binding site [nucleotide binding]; DNA binding site 585054012795 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585054012796 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585054012797 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 585054012798 GTPase RsgA; Reviewed; Region: PRK12288 585054012799 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585054012800 RNA binding site [nucleotide binding]; other site 585054012801 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 585054012802 GTPase/Zn-binding domain interface [polypeptide binding]; other site 585054012803 GTP/Mg2+ binding site [chemical binding]; other site 585054012804 G4 box; other site 585054012805 G5 box; other site 585054012806 G1 box; other site 585054012807 Switch I region; other site 585054012808 G2 box; other site 585054012809 G3 box; other site 585054012810 Switch II region; other site 585054012811 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 585054012812 catalytic site [active] 585054012813 putative active site [active] 585054012814 putative substrate binding site [chemical binding]; other site 585054012815 dimer interface [polypeptide binding]; other site 585054012816 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585054012817 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585054012818 substrate binding pocket [chemical binding]; other site 585054012819 membrane-bound complex binding site; other site 585054012820 hinge residues; other site 585054012821 epoxyqueuosine reductase; Region: TIGR00276 585054012822 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 585054012823 putative carbohydrate kinase; Provisional; Region: PRK10565 585054012824 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 585054012825 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 585054012826 putative substrate binding site [chemical binding]; other site 585054012827 putative ATP binding site [chemical binding]; other site 585054012828 ADP-binding protein; Provisional; Region: PRK10646 585054012829 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 585054012830 AMIN domain; Region: AMIN; pfam11741 585054012831 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585054012832 active site 585054012833 metal binding site [ion binding]; metal-binding site 585054012834 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 585054012835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054012836 ATP binding site [chemical binding]; other site 585054012837 Mg2+ binding site [ion binding]; other site 585054012838 G-X-G motif; other site 585054012839 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 585054012840 ATP binding site [chemical binding]; other site 585054012841 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 585054012842 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 585054012843 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 585054012844 bacterial Hfq-like; Region: Hfq; cd01716 585054012845 hexamer interface [polypeptide binding]; other site 585054012846 Sm1 motif; other site 585054012847 RNA binding site [nucleotide binding]; other site 585054012848 Sm2 motif; other site 585054012849 GTPase HflX; Provisional; Region: PRK11058 585054012850 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 585054012851 HflX GTPase family; Region: HflX; cd01878 585054012852 G1 box; other site 585054012853 GTP/Mg2+ binding site [chemical binding]; other site 585054012854 Switch I region; other site 585054012855 G2 box; other site 585054012856 G3 box; other site 585054012857 Switch II region; other site 585054012858 G4 box; other site 585054012859 G5 box; other site 585054012860 FtsH protease regulator HflK; Provisional; Region: PRK10930 585054012861 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 585054012862 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 585054012863 FtsH protease regulator HflC; Provisional; Region: PRK11029 585054012864 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 585054012865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 585054012866 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 585054012867 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 585054012868 GDP-binding site [chemical binding]; other site 585054012869 ACT binding site; other site 585054012870 IMP binding site; other site 585054012871 Predicted transcriptional regulator [Transcription]; Region: COG1959 585054012872 transcriptional repressor NsrR; Provisional; Region: PRK11014 585054012873 exoribonuclease R; Provisional; Region: PRK11642 585054012874 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 585054012875 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585054012876 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585054012877 RNB domain; Region: RNB; pfam00773 585054012878 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 585054012879 RNA binding site [nucleotide binding]; other site 585054012880 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 585054012881 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 585054012882 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585054012883 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 585054012884 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 585054012885 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 585054012886 Predicted membrane protein [Function unknown]; Region: COG3766 585054012887 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585054012888 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585054012889 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 585054012890 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585054012891 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 585054012892 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 585054012893 FAD binding site [chemical binding]; other site 585054012894 substrate binding site [chemical binding]; other site 585054012895 catalytic residues [active] 585054012896 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585054012897 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 585054012898 esterase; Provisional; Region: PRK10566 585054012899 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585054012900 transcriptional repressor UlaR; Provisional; Region: PRK13509 585054012901 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585054012902 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585054012903 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 585054012904 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 585054012905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 585054012906 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 585054012907 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585054012908 active site 585054012909 P-loop; other site 585054012910 phosphorylation site [posttranslational modification] 585054012911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585054012912 active site 585054012913 phosphorylation site [posttranslational modification] 585054012914 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585054012915 active site 585054012916 dimer interface [polypeptide binding]; other site 585054012917 magnesium binding site [ion binding]; other site 585054012918 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 585054012919 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585054012920 AP (apurinic/apyrimidinic) site pocket; other site 585054012921 DNA interaction; other site 585054012922 Metal-binding active site; metal-binding site 585054012923 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585054012924 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585054012925 intersubunit interface [polypeptide binding]; other site 585054012926 active site 585054012927 Zn2+ binding site [ion binding]; other site 585054012928 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585054012929 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 585054012930 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585054012931 dimer interface [polypeptide binding]; other site 585054012932 ssDNA binding site [nucleotide binding]; other site 585054012933 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585054012934 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 585054012935 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 585054012936 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 585054012937 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 585054012938 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585054012939 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 585054012940 DctM-like transporters; Region: DctM; pfam06808 585054012941 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 585054012942 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585054012943 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 585054012944 L-aspartate oxidase; Provisional; Region: PRK06175 585054012945 L-aspartate oxidase; Provisional; Region: PRK06175 585054012946 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585054012947 Coenzyme A transferase; Region: CoA_trans; smart00882 585054012948 Coenzyme A transferase; Region: CoA_trans; cl17247 585054012949 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 585054012950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585054012951 substrate binding site [chemical binding]; other site 585054012952 oxyanion hole (OAH) forming residues; other site 585054012953 trimer interface [polypeptide binding]; other site 585054012954 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585054012955 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 585054012956 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 585054012957 putative NAD(P) binding site [chemical binding]; other site 585054012958 active site 585054012959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585054012960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054012961 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 585054012962 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 585054012963 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 585054012964 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585054012965 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585054012966 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 585054012967 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 585054012968 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 585054012969 Hemerythrin-like domain; Region: Hr-like; cd12108 585054012970 Fe binding site [ion binding]; other site 585054012971 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585054012972 EamA-like transporter family; Region: EamA; pfam00892 585054012973 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585054012974 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 585054012975 NADP binding site [chemical binding]; other site 585054012976 Predicted transcriptional regulators [Transcription]; Region: COG1733 585054012977 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 585054012978 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 585054012979 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 585054012980 active site 585054012981 metal binding site [ion binding]; metal-binding site 585054012982 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585054012983 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 585054012984 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585054012985 active site 585054012986 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 585054012987 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 585054012988 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585054012989 Domain of unknown function DUF21; Region: DUF21; pfam01595 585054012990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585054012991 Transporter associated domain; Region: CorC_HlyC; smart01091 585054012992 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 585054012993 dimer interface [polypeptide binding]; other site 585054012994 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 585054012995 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 585054012996 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585054012997 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585054012998 putative active site [active] 585054012999 D-allose transporter subunit; Provisional; Region: PRK09701 585054013000 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585054013001 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 585054013002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054013003 Walker A/P-loop; other site 585054013004 ATP binding site [chemical binding]; other site 585054013005 Q-loop/lid; other site 585054013006 ABC transporter signature motif; other site 585054013007 Walker B; other site 585054013008 D-loop; other site 585054013009 H-loop/switch region; other site 585054013010 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054013011 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054013012 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054013013 TM-ABC transporter signature motif; other site 585054013014 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 585054013015 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585054013016 substrate binding site [chemical binding]; other site 585054013017 hexamer interface [polypeptide binding]; other site 585054013018 metal binding site [ion binding]; metal-binding site 585054013019 D-allose kinase; Provisional; Region: PRK09698 585054013020 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585054013021 nucleotide binding site [chemical binding]; other site 585054013022 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 585054013023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585054013024 multidrug resistance protein MdtN; Provisional; Region: PRK10476 585054013025 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585054013026 HlyD family secretion protein; Region: HlyD_3; pfam13437 585054013027 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 585054013028 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585054013029 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 585054013030 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 585054013031 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 585054013032 [4Fe-4S] binding site [ion binding]; other site 585054013033 molybdopterin cofactor binding site; other site 585054013034 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 585054013035 molybdopterin cofactor binding site; other site 585054013036 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054013037 Sel1-like repeats; Region: SEL1; smart00671 585054013038 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 585054013039 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585054013040 acetyl-CoA synthetase; Provisional; Region: PRK00174 585054013041 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 585054013042 active site 585054013043 CoA binding site [chemical binding]; other site 585054013044 acyl-activating enzyme (AAE) consensus motif; other site 585054013045 AMP binding site [chemical binding]; other site 585054013046 acetate binding site [chemical binding]; other site 585054013047 Predicted membrane protein [Function unknown]; Region: COG3162 585054013048 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 585054013049 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 585054013050 Na binding site [ion binding]; other site 585054013051 methionine sulfoxide reductase A; Provisional; Region: PRK00058 585054013052 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 585054013053 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585054013054 Surface antigen; Region: Bac_surface_Ag; pfam01103 585054013055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 585054013056 Family of unknown function (DUF490); Region: DUF490; pfam04357 585054013057 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585054013058 putative active site pocket [active] 585054013059 dimerization interface [polypeptide binding]; other site 585054013060 putative catalytic residue [active] 585054013061 Sel1-like repeats; Region: SEL1; smart00671 585054013062 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054013063 Sel1-like repeats; Region: SEL1; smart00671 585054013064 Sel1-like repeats; Region: SEL1; smart00671 585054013065 Sel1-like repeats; Region: SEL1; smart00671 585054013066 Sel1-like repeats; Region: SEL1; smart00671 585054013067 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585054013068 Sel1-like repeats; Region: SEL1; smart00671 585054013069 Sel1-like repeats; Region: SEL1; smart00671 585054013070 Sel1-like repeats; Region: SEL1; smart00671 585054013071 Sel1-like repeats; Region: SEL1; smart00671 585054013072 Sel1-like repeats; Region: SEL1; smart00671 585054013073 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585054013074 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 585054013075 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054013076 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 585054013077 dimer interface [polypeptide binding]; other site 585054013078 substrate binding site [chemical binding]; other site 585054013079 metal binding sites [ion binding]; metal-binding site 585054013080 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 585054013081 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585054013082 putative ligand binding site [chemical binding]; other site 585054013083 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585054013084 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585054013085 Walker A/P-loop; other site 585054013086 ATP binding site [chemical binding]; other site 585054013087 Q-loop/lid; other site 585054013088 ABC transporter signature motif; other site 585054013089 Walker B; other site 585054013090 D-loop; other site 585054013091 H-loop/switch region; other site 585054013092 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585054013093 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054013094 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054013095 TM-ABC transporter signature motif; other site 585054013096 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585054013097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585054013098 TM-ABC transporter signature motif; other site 585054013099 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 585054013100 AMP binding site [chemical binding]; other site 585054013101 metal binding site [ion binding]; metal-binding site 585054013102 active site 585054013103 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 585054013104 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585054013105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585054013106 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585054013107 hypothetical protein; Provisional; Region: PRK05255 585054013108 peptidase PmbA; Provisional; Region: PRK11040 585054013109 cytochrome b562; Provisional; Region: PRK15058 585054013110 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 585054013111 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 585054013112 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 585054013113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054013114 FeS/SAM binding site; other site 585054013115 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 585054013116 ATP cone domain; Region: ATP-cone; pfam03477 585054013117 Class III ribonucleotide reductase; Region: RNR_III; cd01675 585054013118 effector binding site; other site 585054013119 active site 585054013120 Zn binding site [ion binding]; other site 585054013121 glycine loop; other site 585054013122 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 585054013123 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 585054013124 Ca binding site [ion binding]; other site 585054013125 active site 585054013126 catalytic site [active] 585054013127 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 585054013128 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 585054013129 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585054013130 active site turn [active] 585054013131 phosphorylation site [posttranslational modification] 585054013132 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585054013133 trehalose repressor; Provisional; Region: treR; PRK09492 585054013134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585054013135 DNA binding site [nucleotide binding] 585054013136 domain linker motif; other site 585054013137 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 585054013138 dimerization interface [polypeptide binding]; other site 585054013139 ligand binding site [chemical binding]; other site 585054013140 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585054013141 DNA-binding interface [nucleotide binding]; DNA binding site 585054013142 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585054013143 homotrimer interaction site [polypeptide binding]; other site 585054013144 putative active site [active] 585054013145 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 585054013146 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 585054013147 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 585054013148 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 585054013149 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585054013150 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585054013151 Arginine repressor [Transcription]; Region: ArgR; COG1438 585054013152 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 585054013153 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 585054013154 Predicted membrane protein [Function unknown]; Region: COG1288 585054013155 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585054013156 ornithine carbamoyltransferase; Validated; Region: PRK02102 585054013157 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585054013158 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585054013159 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585054013160 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585054013161 putative substrate binding site [chemical binding]; other site 585054013162 nucleotide binding site [chemical binding]; other site 585054013163 nucleotide binding site [chemical binding]; other site 585054013164 homodimer interface [polypeptide binding]; other site 585054013165 arginine deiminase; Provisional; Region: PRK01388 585054013166 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585054013167 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 585054013168 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585054013169 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585054013170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 585054013171 RNase E inhibitor protein; Provisional; Region: PRK11191 585054013172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585054013173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054013174 Coenzyme A binding pocket [chemical binding]; other site 585054013175 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 585054013176 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 585054013177 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585054013178 HIGH motif; other site 585054013179 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585054013180 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585054013181 active site 585054013182 KMSKS motif; other site 585054013183 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 585054013184 tRNA binding surface [nucleotide binding]; other site 585054013185 anticodon binding site; other site 585054013186 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 585054013187 DNA polymerase III subunit chi; Validated; Region: PRK05728 585054013188 multifunctional aminopeptidase A; Provisional; Region: PRK00913 585054013189 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585054013190 interface (dimer of trimers) [polypeptide binding]; other site 585054013191 Substrate-binding/catalytic site; other site 585054013192 Zn-binding sites [ion binding]; other site 585054013193 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 585054013194 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585054013195 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 585054013196 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585054013197 outer membrane lipoprotein; Provisional; Region: PRK11023 585054013198 BON domain; Region: BON; pfam04972 585054013199 BON domain; Region: BON; pfam04972 585054013200 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585054013201 dimer interface [polypeptide binding]; other site 585054013202 active site 585054013203 TIGR00252 family protein; Region: TIGR00252 585054013204 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585054013205 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 585054013206 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 585054013207 putative ligand binding site [chemical binding]; other site 585054013208 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 585054013209 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 585054013210 putative SAM binding site [chemical binding]; other site 585054013211 putative homodimer interface [polypeptide binding]; other site 585054013212 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585054013213 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585054013214 active site 585054013215 trimer interface [polypeptide binding]; other site 585054013216 allosteric site; other site 585054013217 active site lid [active] 585054013218 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585054013219 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 585054013220 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 585054013221 PTS system N-acetylgalactosamine-specific transporter subunit IIB; Provisional; Region: PRK09756 585054013222 active site 585054013223 phosphorylation site [posttranslational modification] 585054013224 tagatose-bisphosphate aldolase; Reviewed; Region: kbaY; PRK12738 585054013225 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585054013226 active site 585054013227 intersubunit interface [polypeptide binding]; other site 585054013228 zinc binding site [ion binding]; other site 585054013229 Na+ binding site [ion binding]; other site 585054013230 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 585054013231 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585054013232 dimer interface [polypeptide binding]; other site 585054013233 active site 585054013234 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 585054013235 putative active site [active] 585054013236 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 585054013237 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585054013238 active site 585054013239 dimer interface [polypeptide binding]; other site 585054013240 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585054013241 active pocket/dimerization site; other site 585054013242 active site 585054013243 phosphorylation site [posttranslational modification] 585054013244 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 585054013245 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 585054013246 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585054013247 active site 585054013248 phosphorylation site [posttranslational modification] 585054013249 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 585054013250 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 585054013251 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585054013252 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585054013253 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 585054013254 putative regulator PrlF; Provisional; Region: PRK09974 585054013255 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 585054013256 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585054013257 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585054013258 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585054013259 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 585054013260 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 585054013261 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585054013262 Pirin-related protein [General function prediction only]; Region: COG1741 585054013263 Pirin; Region: Pirin; pfam02678 585054013264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585054013265 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585054013266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585054013267 dimerization interface [polypeptide binding]; other site 585054013268 Predicted membrane protein [Function unknown]; Region: COG3152 585054013269 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 585054013270 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 585054013271 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 585054013272 putative dimer interface [polypeptide binding]; other site 585054013273 N-terminal domain interface [polypeptide binding]; other site 585054013274 putative substrate binding pocket (H-site) [chemical binding]; other site 585054013275 Predicted membrane protein [Function unknown]; Region: COG2259 585054013276 YqjK-like protein; Region: YqjK; pfam13997 585054013277 Predicted membrane protein [Function unknown]; Region: COG5393 585054013278 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 585054013279 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 585054013280 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 585054013281 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585054013282 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585054013283 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 585054013284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054013285 DNA-binding site [nucleotide binding]; DNA binding site 585054013286 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585054013287 D-galactonate transporter; Region: 2A0114; TIGR00893 585054013288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054013289 putative substrate translocation pore; other site 585054013290 Glucuronate isomerase; Region: UxaC; pfam02614 585054013291 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 585054013292 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585054013293 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585054013294 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585054013295 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 585054013296 serine/threonine transporter SstT; Provisional; Region: PRK13628 585054013297 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585054013298 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585054013299 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585054013300 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585054013301 Evidence 7 : Gene remnant; Product type pc : carrier; fragment of thioredoxin-like (part 2) 585054013302 Evidence 7 : Gene remnant; Product type pc : carrier; fragment of thioredoxin-like (part 1) 585054013303 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 585054013304 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 585054013305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054013306 S-adenosylmethionine binding site [chemical binding]; other site 585054013307 phosphoglycerol transferase I; Provisional; Region: PRK03776 585054013308 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 585054013309 hypothetical protein; Provisional; Region: PRK11667 585054013310 DNA replication protein DnaC; Validated; Region: PRK07952 585054013311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585054013312 Walker A motif; other site 585054013313 ATP binding site [chemical binding]; other site 585054013314 Walker B motif; other site 585054013315 primosomal protein DnaI; Provisional; Region: PRK02854 585054013316 hypothetical protein; Provisional; Region: PRK09917 585054013317 Uncharacterized conserved protein [Function unknown]; Region: COG2966 585054013318 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 585054013319 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585054013320 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 585054013321 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 585054013322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054013323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585054013324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054013325 DNA binding residues [nucleotide binding] 585054013326 dimerization interface [polypeptide binding]; other site 585054013327 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 585054013328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585054013329 DNA binding residues [nucleotide binding] 585054013330 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 585054013331 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585054013332 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 585054013333 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 585054013334 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 585054013335 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 585054013336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585054013337 S-adenosylmethionine binding site [chemical binding]; other site 585054013338 DNA polymerase III subunit psi; Validated; Region: PRK06856 585054013339 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 585054013340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585054013341 Coenzyme A binding pocket [chemical binding]; other site 585054013342 dUMP phosphatase; Provisional; Region: PRK09449 585054013343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054013344 motif II; other site 585054013345 integrase; Provisional; Region: PRK09692 585054013346 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585054013347 active site 585054013348 Int/Topo IB signature motif; other site 585054013349 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585054013350 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585054013351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054013352 non-specific DNA binding site [nucleotide binding]; other site 585054013353 salt bridge; other site 585054013354 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585054013355 sequence-specific DNA binding site [nucleotide binding]; other site 585054013356 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054013357 Catalytic site [active] 585054013358 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585054013359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585054013360 DNA-binding site [nucleotide binding]; DNA binding site 585054013361 PerC transcriptional activator; Region: PerC; pfam06069 585054013362 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585054013363 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 585054013364 KilA-N domain; Region: KilA-N; pfam04383 585054013365 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585054013366 Antitermination protein; Region: Antiterm; pfam03589 585054013367 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585054013368 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 585054013369 Antitermination protein; Region: Antiterm; pfam03589 585054013370 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054013371 DNA-binding site [nucleotide binding]; DNA binding site 585054013372 RNA-binding motif; other site 585054013373 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054013374 DNA-binding site [nucleotide binding]; DNA binding site 585054013375 RNA-binding motif; other site 585054013376 Lysis protein S; Region: Lysis_S; pfam04971 585054013377 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585054013378 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 585054013379 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585054013380 catalytic residues [active] 585054013381 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 585054013382 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585054013383 DNA-binding site [nucleotide binding]; DNA binding site 585054013384 RNA-binding motif; other site 585054013385 GnsA/GnsB family; Region: GnsAB; pfam08178 585054013386 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585054013387 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585054013388 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 585054013389 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585054013390 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585054013391 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585054013392 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585054013393 oligomer interface [polypeptide binding]; other site 585054013394 active site residues [active] 585054013395 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585054013396 Uncharacterized conserved protein [Function unknown]; Region: COG5471 585054013397 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585054013398 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585054013399 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585054013400 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585054013401 Bacterial Ig-like domain 2; Region: BID_2; smart00635 585054013402 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 585054013403 Minor tail protein T; Region: Phage_tail_T; pfam06223 585054013404 Phage-related minor tail protein [Function unknown]; Region: COG5281 585054013405 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585054013406 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585054013407 Phage-related protein [Function unknown]; Region: COG4718 585054013408 Phage-related protein [Function unknown]; Region: gp18; COG4672 585054013409 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585054013410 MPN+ (JAMM) motif; other site 585054013411 Zinc-binding site [ion binding]; other site 585054013412 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585054013413 NlpC/P60 family; Region: NLPC_P60; cl17555 585054013414 Phage-related protein, tail component [Function unknown]; Region: COG4723 585054013415 Phage-related protein, tail component [Function unknown]; Region: COG4733 585054013416 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585054013417 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585054013418 Fibronectin type III protein; Region: DUF3672; pfam12421 585054013419 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585054013420 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585054013421 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585054013422 Phage Tail Collar Domain; Region: Collar; pfam07484 585054013423 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of conserved hypothetical protein; protein (partial) 585054013424 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585054013425 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585054013426 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585054013427 catalytic residues [active] 585054013428 catalytic nucleophile [active] 585054013429 Presynaptic Site I dimer interface [polypeptide binding]; other site 585054013430 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585054013431 Synaptic Flat tetramer interface [polypeptide binding]; other site 585054013432 Synaptic Site I dimer interface [polypeptide binding]; other site 585054013433 DNA binding site [nucleotide binding] 585054013434 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585054013435 DNA-binding interface [nucleotide binding]; DNA binding site 585054013436 DinI-like family; Region: DinI; pfam06183 585054013437 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 585054013438 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 585054013439 G1 box; other site 585054013440 putative GEF interaction site [polypeptide binding]; other site 585054013441 GTP/Mg2+ binding site [chemical binding]; other site 585054013442 Switch I region; other site 585054013443 G2 box; other site 585054013444 G3 box; other site 585054013445 Switch II region; other site 585054013446 G4 box; other site 585054013447 G5 box; other site 585054013448 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 585054013449 periplasmic protein; Provisional; Region: PRK10568 585054013450 BON domain; Region: BON; pfam04972 585054013451 BON domain; Region: BON; pfam04972 585054013452 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 585054013453 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 585054013454 active site 585054013455 nucleophile elbow; other site 585054013456 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585054013457 active site 585054013458 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 585054013459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585054013460 FeS/SAM binding site; other site 585054013461 hypothetical protein; Provisional; Region: PRK10977 585054013462 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 585054013463 intersubunit interface [polypeptide binding]; other site 585054013464 active site 585054013465 catalytic residue [active] 585054013466 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 585054013467 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585054013468 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585054013469 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 585054013470 phosphopentomutase; Provisional; Region: PRK05362 585054013471 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 585054013472 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 585054013473 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 585054013474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054013475 non-specific DNA binding site [nucleotide binding]; other site 585054013476 salt bridge; other site 585054013477 sequence-specific DNA binding site [nucleotide binding]; other site 585054013478 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 585054013479 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 585054013480 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 585054013481 hypothetical protein; Provisional; Region: PRK11246 585054013482 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 585054013483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585054013484 motif II; other site 585054013485 DNA repair protein RadA; Region: sms; TIGR00416 585054013486 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 585054013487 Walker A motif/ATP binding site; other site 585054013488 ATP binding site [chemical binding]; other site 585054013489 Walker B motif; other site 585054013490 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585054013491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054013492 non-specific DNA binding site [nucleotide binding]; other site 585054013493 salt bridge; other site 585054013494 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 585054013495 sequence-specific DNA binding site [nucleotide binding]; other site 585054013496 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 585054013497 active site 585054013498 (T/H)XGH motif; other site 585054013499 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585054013500 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 585054013501 Predicted transcriptional regulator [Transcription]; Region: COG2944 585054013502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585054013503 non-specific DNA binding site [nucleotide binding]; other site 585054013504 salt bridge; other site 585054013505 sequence-specific DNA binding site [nucleotide binding]; other site 585054013506 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 585054013507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585054013508 Walker A/P-loop; other site 585054013509 ATP binding site [chemical binding]; other site 585054013510 Q-loop/lid; other site 585054013511 ABC transporter signature motif; other site 585054013512 Walker B; other site 585054013513 D-loop; other site 585054013514 H-loop/switch region; other site 585054013515 ABC transporter; Region: ABC_tran_2; pfam12848 585054013516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585054013517 lytic murein transglycosylase; Provisional; Region: PRK11619 585054013518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585054013519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585054013520 catalytic residue [active] 585054013521 Trp operon repressor; Provisional; Region: PRK01381 585054013522 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 585054013523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585054013524 catalytic core [active] 585054013525 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585054013526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054013527 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 585054013528 hypothetical protein; Provisional; Region: PRK10756 585054013529 CreA protein; Region: CreA; pfam05981 585054013530 DNA-binding response regulator CreB; Provisional; Region: PRK11083 585054013531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054013532 active site 585054013533 phosphorylation site [posttranslational modification] 585054013534 intermolecular recognition site; other site 585054013535 dimerization interface [polypeptide binding]; other site 585054013536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054013537 DNA binding site [nucleotide binding] 585054013538 sensory histidine kinase CreC; Provisional; Region: PRK11100 585054013539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585054013540 dimerization interface [polypeptide binding]; other site 585054013541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585054013542 dimer interface [polypeptide binding]; other site 585054013543 phosphorylation site [posttranslational modification] 585054013544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585054013545 ATP binding site [chemical binding]; other site 585054013546 Mg2+ binding site [ion binding]; other site 585054013547 G-X-G motif; other site 585054013548 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 585054013549 two-component response regulator; Provisional; Region: PRK11173 585054013550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585054013551 active site 585054013552 phosphorylation site [posttranslational modification] 585054013553 intermolecular recognition site; other site 585054013554 dimerization interface [polypeptide binding]; other site 585054013555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585054013556 DNA binding site [nucleotide binding] 585054013557 putative RNA methyltransferase; Provisional; Region: PRK10433 585054013558 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 585054013559 Initiator Replication protein; Region: Rep_3; pfam01051 585054013560 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 585054013561 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 585054013562 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585054013563 P-loop; other site 585054013564 Magnesium ion binding site [ion binding]; other site 585054013565 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585054013566 Magnesium ion binding site [ion binding]; other site 585054013567 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 585054013568 ParB-like nuclease domain; Region: ParBc; pfam02195 585054013569 ParB family; Region: ParB; pfam08775 585054013570 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 585054013571 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 585054013572 active site 585054013573 DNA binding site [nucleotide binding] 585054013574 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585054013575 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585054013576 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585054013577 Catalytic site [active] 585054013578 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585054013579 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 585054013580 putative active site [active] 585054013581 putative nucleic acid binding site [nucleotide binding]; other site 585054013582 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585054013583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585054013584 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585054013585 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585054013586 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 585054013587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054013588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 585054013589 Integrase core domain; Region: rve; pfam00665 585054013590 Integrase core domain; Region: rve_3; pfam13683 585054013591 WYL domain; Region: WYL; pfam13280 585054013592 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 585054013593 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 585054013594 Uncharacterized conserved protein [Function unknown]; Region: COG1479 585054013595 Protein of unknown function DUF262; Region: DUF262; pfam03235 585054013596 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 585054013597 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585054013598 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 585054013599 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 585054013600 TIGR02687 family protein; Region: TIGR02687 585054013601 PglZ domain; Region: PglZ; pfam08665 585054013602 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 585054013603 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 585054013604 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585054013605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585054013606 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585054013607 Integrase core domain; Region: rve_2; pfam13333 585054013608 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 585054013609 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 585054013610 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585054013611 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585054013612 catalytic residues [active] 585054013613 catalytic nucleophile [active] 585054013614 Presynaptic Site I dimer interface [polypeptide binding]; other site 585054013615 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585054013616 Synaptic Flat tetramer interface [polypeptide binding]; other site 585054013617 Synaptic Site I dimer interface [polypeptide binding]; other site 585054013618 DNA binding site [nucleotide binding] 585054013619 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585054013620 DNA-binding interface [nucleotide binding]; DNA binding site 585054013621 Transposase; Region: HTH_Tnp_1; cl17663 585054013622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585054013623 fragment of IS3 element protein InsF (part 2);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585054013624 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 585054013625 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 585054013626 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585054013627 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585054013628 catalytic residues [active] 585054013629 catalytic nucleophile [active] 585054013630 Presynaptic Site I dimer interface [polypeptide binding]; other site 585054013631 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585054013632 Synaptic Flat tetramer interface [polypeptide binding]; other site 585054013633 Synaptic Site I dimer interface [polypeptide binding]; other site 585054013634 DNA binding site [nucleotide binding] 585054013635 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 585054013636 beta-lactamase TEM; Provisional; Region: PRK15442 585054013637 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 585054013638 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054013639 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585054013640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054013641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585054013642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585054013643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054013644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585054013645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585054013646 putative substrate translocation pore; other site 585054013647 tetracycline repressor protein TetR; Provisional; Region: PRK13756 585054013648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585054013649 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 585054013650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585054013651 dimerization interface [polypeptide binding]; other site 585054013652 putative DNA binding site [nucleotide binding]; other site 585054013653 putative Zn2+ binding site [ion binding]; other site 585054013654 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585054013655 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 585054013656 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 585054013657 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585054013658 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 585054013659 Phosphotransferase enzyme family; Region: APH; pfam01636 585054013660 active site 585054013661 ATP binding site [chemical binding]; other site 585054013662 antibiotic binding site [chemical binding]; other site 585054013663 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 585054013664 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585054013665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585054013666 HTH-like domain; Region: HTH_21; pfam13276 585054013667 Integrase core domain; Region: rve; pfam00665 585054013668 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 585054013669 oligomeric interface; other site 585054013670 putative active site [active] 585054013671 homodimer interface [polypeptide binding]; other site 585054013672 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 585054013673 Phage integrase family; Region: Phage_integrase; pfam00589 585054013674 active site 585054013675 DNA binding site [nucleotide binding] 585054013676 Int/Topo IB signature motif; other site