-- dump date 20140619_091641 -- class Genbank::misc_feature -- table misc_feature_note -- id note 663278000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 663278000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 663278000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000004 Walker A motif; other site 663278000005 ATP binding site [chemical binding]; other site 663278000006 Walker B motif; other site 663278000007 arginine finger; other site 663278000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 663278000009 DnaA box-binding interface [nucleotide binding]; other site 663278000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 663278000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 663278000012 putative DNA binding surface [nucleotide binding]; other site 663278000013 dimer interface [polypeptide binding]; other site 663278000014 beta-clamp/clamp loader binding surface; other site 663278000015 beta-clamp/translesion DNA polymerase binding surface; other site 663278000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278000017 RNA binding surface [nucleotide binding]; other site 663278000018 recombination protein F; Reviewed; Region: recF; PRK00064 663278000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278000020 Walker A/P-loop; other site 663278000021 ATP binding site [chemical binding]; other site 663278000022 Q-loop/lid; other site 663278000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278000024 ABC transporter signature motif; other site 663278000025 Walker B; other site 663278000026 D-loop; other site 663278000027 H-loop/switch region; other site 663278000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 663278000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278000030 Mg2+ binding site [ion binding]; other site 663278000031 G-X-G motif; other site 663278000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 663278000033 anchoring element; other site 663278000034 dimer interface [polypeptide binding]; other site 663278000035 ATP binding site [chemical binding]; other site 663278000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 663278000037 active site 663278000038 putative metal-binding site [ion binding]; other site 663278000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 663278000040 DNA gyrase subunit A; Validated; Region: PRK05560 663278000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 663278000042 CAP-like domain; other site 663278000043 active site 663278000044 primary dimer interface [polypeptide binding]; other site 663278000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 663278000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 663278000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 663278000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 663278000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 663278000050 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 663278000051 active site 663278000052 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278000053 Transcriptional regulators [Transcription]; Region: MarR; COG1846 663278000054 MarR family; Region: MarR; pfam01047 663278000055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 663278000056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278000057 putative substrate translocation pore; other site 663278000058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278000059 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 663278000060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278000061 active site 663278000062 dihydroorotase; Validated; Region: pyrC; PRK09357 663278000063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 663278000064 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 663278000065 active site 663278000066 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 663278000067 active site 663278000068 dimer interface [polypeptide binding]; other site 663278000069 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 663278000070 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 663278000071 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 663278000072 catalytic site [active] 663278000073 subunit interface [polypeptide binding]; other site 663278000074 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 663278000075 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 663278000076 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 663278000077 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 663278000078 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 663278000079 ATP-grasp domain; Region: ATP-grasp_4; cl17255 663278000080 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 663278000081 substrate binding site [chemical binding]; other site 663278000082 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 663278000083 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 663278000084 FAD binding pocket [chemical binding]; other site 663278000085 FAD binding motif [chemical binding]; other site 663278000086 phosphate binding motif [ion binding]; other site 663278000087 beta-alpha-beta structure motif; other site 663278000088 NAD binding pocket [chemical binding]; other site 663278000089 Iron coordination center [ion binding]; other site 663278000090 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 663278000091 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 663278000092 heterodimer interface [polypeptide binding]; other site 663278000093 active site 663278000094 FMN binding site [chemical binding]; other site 663278000095 homodimer interface [polypeptide binding]; other site 663278000096 substrate binding site [chemical binding]; other site 663278000097 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 663278000098 catalytic core [active] 663278000099 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 663278000100 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 663278000101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278000102 S-adenosylmethionine binding site [chemical binding]; other site 663278000103 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 663278000104 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 663278000105 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278000106 hypothetical protein; Validated; Region: PRK00110 663278000107 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 663278000108 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 663278000109 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 663278000110 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 663278000111 dimer interface [polypeptide binding]; other site 663278000112 substrate binding site [chemical binding]; other site 663278000113 ATP binding site [chemical binding]; other site 663278000114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278000115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278000116 Protein of unknown function DUF45; Region: DUF45; pfam01863 663278000117 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 663278000118 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 663278000119 homodimer interface [polypeptide binding]; other site 663278000120 substrate-cofactor binding pocket; other site 663278000121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278000122 catalytic residue [active] 663278000123 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 663278000124 putative ligand binding site [chemical binding]; other site 663278000125 putative NAD binding site [chemical binding]; other site 663278000126 putative catalytic site [active] 663278000127 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 663278000128 L-serine binding site [chemical binding]; other site 663278000129 ACT domain interface; other site 663278000130 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 663278000131 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 663278000132 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 663278000133 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 663278000134 substrate binding site [chemical binding]; other site 663278000135 hexamer interface [polypeptide binding]; other site 663278000136 metal binding site [ion binding]; metal-binding site 663278000137 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 663278000138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 663278000139 active site 663278000140 catalytic tetrad [active] 663278000141 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 663278000142 L-aspartate oxidase; Provisional; Region: PRK06175 663278000143 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 663278000144 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 663278000145 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 663278000146 dimerization interface [polypeptide binding]; other site 663278000147 active site 663278000148 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 663278000149 active site 663278000150 Mo-co oxidoreductase dimerisation domain; Region: Mo-co_dimer; pfam03404 663278000151 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 663278000152 PAS fold; Region: PAS; pfam00989 663278000153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 663278000154 putative active site [active] 663278000155 heme pocket [chemical binding]; other site 663278000156 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278000157 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278000158 metal binding site [ion binding]; metal-binding site 663278000159 active site 663278000160 I-site; other site 663278000161 Predicted membrane protein [Function unknown]; Region: COG3601 663278000162 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 663278000163 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 663278000164 active site 663278000165 NTP binding site [chemical binding]; other site 663278000166 metal binding triad [ion binding]; metal-binding site 663278000167 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 663278000168 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 663278000169 G1 box; other site 663278000170 GTP/Mg2+ binding site [chemical binding]; other site 663278000171 Switch I region; other site 663278000172 G2 box; other site 663278000173 Switch II region; other site 663278000174 G3 box; other site 663278000175 G4 box; other site 663278000176 G5 box; other site 663278000177 Cupin domain; Region: Cupin_2; cl17218 663278000178 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 663278000179 Aspartase; Region: Aspartase; cd01357 663278000180 active sites [active] 663278000181 tetramer interface [polypeptide binding]; other site 663278000182 biotin synthase; Provisional; Region: PRK07094 663278000183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278000184 FeS/SAM binding site; other site 663278000185 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 663278000186 FOG: CBS domain [General function prediction only]; Region: COG0517 663278000187 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 663278000188 DHHA2 domain; Region: DHHA2; pfam02833 663278000189 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 663278000190 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 663278000191 putative active site [active] 663278000192 metal binding site [ion binding]; metal-binding site 663278000193 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 663278000194 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 663278000195 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 663278000196 Putative Fe-S cluster; Region: FeS; cl17515 663278000197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 663278000198 putative active site [active] 663278000199 heme pocket [chemical binding]; other site 663278000200 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 663278000201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278000202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278000203 non-specific DNA binding site [nucleotide binding]; other site 663278000204 salt bridge; other site 663278000205 sequence-specific DNA binding site [nucleotide binding]; other site 663278000206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278000207 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 663278000208 FtsX-like permease family; Region: FtsX; pfam02687 663278000209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278000210 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278000211 Walker A/P-loop; other site 663278000212 ATP binding site [chemical binding]; other site 663278000213 Q-loop/lid; other site 663278000214 ABC transporter signature motif; other site 663278000215 Walker B; other site 663278000216 D-loop; other site 663278000217 H-loop/switch region; other site 663278000218 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 663278000219 E3 interaction surface; other site 663278000220 lipoyl attachment site [posttranslational modification]; other site 663278000221 HlyD family secretion protein; Region: HlyD_3; pfam13437 663278000222 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 663278000223 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 663278000224 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 663278000225 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 663278000226 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 663278000227 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 663278000228 B12 binding site [chemical binding]; other site 663278000229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278000230 FeS/SAM binding site; other site 663278000231 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 663278000232 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 663278000233 putative metal binding site [ion binding]; other site 663278000234 Uncharacterized conserved protein [Function unknown]; Region: COG1432 663278000235 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 663278000236 GAF domain; Region: GAF_3; pfam13492 663278000237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278000238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278000239 metal binding site [ion binding]; metal-binding site 663278000240 active site 663278000241 I-site; other site 663278000242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278000243 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 663278000244 GAF domain; Region: GAF; pfam01590 663278000245 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278000246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278000247 metal binding site [ion binding]; metal-binding site 663278000248 active site 663278000249 I-site; other site 663278000250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278000251 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 663278000252 oligomerization interface [polypeptide binding]; other site 663278000253 active site 663278000254 metal binding site [ion binding]; metal-binding site 663278000255 pantoate--beta-alanine ligase; Region: panC; TIGR00018 663278000256 Pantoate-beta-alanine ligase; Region: PanC; cd00560 663278000257 active site 663278000258 ATP-binding site [chemical binding]; other site 663278000259 pantoate-binding site; other site 663278000260 HXXH motif; other site 663278000261 Domain of unknown function (DUF955); Region: DUF955; pfam06114 663278000262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278000263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278000264 non-specific DNA binding site [nucleotide binding]; other site 663278000265 salt bridge; other site 663278000266 sequence-specific DNA binding site [nucleotide binding]; other site 663278000267 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 663278000268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000269 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 663278000270 Walker A motif; other site 663278000271 ATP binding site [chemical binding]; other site 663278000272 Walker B motif; other site 663278000273 arginine finger; other site 663278000274 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 663278000275 Integrase core domain; Region: rve; pfam00665 663278000276 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 663278000277 AAA domain; Region: AAA_22; pfam13401 663278000278 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 663278000279 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 663278000280 Mor transcription activator family; Region: Mor; cl02360 663278000281 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 663278000282 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 2; Region: NGN_Bact_2; cd09889 663278000283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 663278000284 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 663278000285 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 663278000286 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 663278000287 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 663278000288 Phage capsid family; Region: Phage_capsid; pfam05065 663278000289 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 663278000290 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 663278000291 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 663278000292 Minor capsid protein; Region: Minor_capsid_2; pfam11114 663278000293 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 663278000294 tape measure domain; Region: tape_meas_nterm; TIGR02675 663278000295 Phage tail protein; Region: Sipho_tail; cl17486 663278000296 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 663278000297 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278000298 active site 663278000299 Bacterial SH3 domain; Region: SH3_3; cl17532 663278000300 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 663278000301 active site 663278000302 multiple promoter invertase; Provisional; Region: mpi; PRK13413 663278000303 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 663278000304 catalytic residues [active] 663278000305 catalytic nucleophile [active] 663278000306 Presynaptic Site I dimer interface [polypeptide binding]; other site 663278000307 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 663278000308 Synaptic Flat tetramer interface [polypeptide binding]; other site 663278000309 Synaptic Site I dimer interface [polypeptide binding]; other site 663278000310 DNA binding site [nucleotide binding] 663278000311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278000312 DsrE/DsrF-like family; Region: DrsE; cl00672 663278000313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278000314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278000315 metal binding site [ion binding]; metal-binding site 663278000316 active site 663278000317 I-site; other site 663278000318 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278000319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278000320 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 663278000321 Walker A/P-loop; other site 663278000322 ATP binding site [chemical binding]; other site 663278000323 Q-loop/lid; other site 663278000324 ABC transporter signature motif; other site 663278000325 Walker B; other site 663278000326 D-loop; other site 663278000327 H-loop/switch region; other site 663278000328 YibE/F-like protein; Region: YibE_F; pfam07907 663278000329 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 663278000330 active site 663278000331 metal binding site [ion binding]; metal-binding site 663278000332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278000333 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278000334 active site 663278000335 metal binding site [ion binding]; metal-binding site 663278000336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 663278000337 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 663278000338 Probable Catalytic site; other site 663278000339 metal-binding site 663278000340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 663278000341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278000342 S-adenosylmethionine binding site [chemical binding]; other site 663278000343 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 663278000344 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 663278000345 putative metal binding site; other site 663278000346 TPR repeat; Region: TPR_11; pfam13414 663278000347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 663278000348 binding surface 663278000349 TPR motif; other site 663278000350 TPR repeat; Region: TPR_11; pfam13414 663278000351 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 663278000352 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 663278000353 ligand binding site [chemical binding]; other site 663278000354 flexible hinge region; other site 663278000355 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 663278000356 putative switch regulator; other site 663278000357 non-specific DNA interactions [nucleotide binding]; other site 663278000358 DNA binding site [nucleotide binding] 663278000359 sequence specific DNA binding site [nucleotide binding]; other site 663278000360 putative cAMP binding site [chemical binding]; other site 663278000361 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 663278000362 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 663278000363 catalytic residues [active] 663278000364 Methyltransferase domain; Region: Methyltransf_23; pfam13489 663278000365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278000366 S-adenosylmethionine binding site [chemical binding]; other site 663278000367 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 663278000368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 663278000369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 663278000370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 663278000371 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 663278000372 active site residue [active] 663278000373 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 663278000374 CPxP motif; other site 663278000375 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 663278000376 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278000377 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278000378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000379 Walker A motif; other site 663278000380 ATP binding site [chemical binding]; other site 663278000381 Walker B motif; other site 663278000382 arginine finger; other site 663278000383 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 663278000384 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 663278000385 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 663278000386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278000387 DNA-binding site [nucleotide binding]; DNA binding site 663278000388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278000389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278000390 homodimer interface [polypeptide binding]; other site 663278000391 catalytic residue [active] 663278000392 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 663278000393 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 663278000394 active site 663278000395 multimer interface [polypeptide binding]; other site 663278000396 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 663278000397 predicted active site [active] 663278000398 catalytic triad [active] 663278000399 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 663278000400 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 663278000401 putative dimer interface [polypeptide binding]; other site 663278000402 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 663278000403 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 663278000404 putative catalytic cysteine [active] 663278000405 gamma-glutamyl kinase; Provisional; Region: PRK05429 663278000406 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 663278000407 nucleotide binding site [chemical binding]; other site 663278000408 homotetrameric interface [polypeptide binding]; other site 663278000409 putative phosphate binding site [ion binding]; other site 663278000410 putative allosteric binding site; other site 663278000411 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 663278000412 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 663278000413 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 663278000414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278000415 FeS/SAM binding site; other site 663278000416 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 663278000417 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 663278000418 ornithine carbamoyltransferase; Provisional; Region: PRK00779 663278000419 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 663278000420 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 663278000421 acetylornithine aminotransferase; Provisional; Region: PRK02627 663278000422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 663278000423 inhibitor-cofactor binding pocket; inhibition site 663278000424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278000425 catalytic residue [active] 663278000426 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 663278000427 putative FMN binding site [chemical binding]; other site 663278000428 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 663278000429 feedback inhibition sensing region; other site 663278000430 homohexameric interface [polypeptide binding]; other site 663278000431 nucleotide binding site [chemical binding]; other site 663278000432 N-acetyl-L-glutamate binding site [chemical binding]; other site 663278000433 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 663278000434 heterotetramer interface [polypeptide binding]; other site 663278000435 active site pocket [active] 663278000436 cleavage site 663278000437 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 663278000438 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 663278000439 argininosuccinate lyase; Provisional; Region: PRK00855 663278000440 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 663278000441 active sites [active] 663278000442 tetramer interface [polypeptide binding]; other site 663278000443 argininosuccinate synthase; Provisional; Region: PRK13820 663278000444 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 663278000445 ANP binding site [chemical binding]; other site 663278000446 Substrate Binding Site II [chemical binding]; other site 663278000447 Substrate Binding Site I [chemical binding]; other site 663278000448 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 663278000449 phosphate binding site [ion binding]; other site 663278000450 Flavin Reductases; Region: FlaRed; cl00801 663278000451 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 663278000452 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 663278000453 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 663278000454 dimer interface [polypeptide binding]; other site 663278000455 putative anticodon binding site; other site 663278000456 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 663278000457 motif 1; other site 663278000458 active site 663278000459 motif 2; other site 663278000460 motif 3; other site 663278000461 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 663278000462 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 663278000463 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 663278000464 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 663278000465 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 663278000466 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 663278000467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278000468 Walker A/P-loop; other site 663278000469 ATP binding site [chemical binding]; other site 663278000470 Q-loop/lid; other site 663278000471 ABC transporter signature motif; other site 663278000472 Walker B; other site 663278000473 D-loop; other site 663278000474 H-loop/switch region; other site 663278000475 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 663278000476 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 663278000477 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 663278000478 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 663278000479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278000480 RNA binding surface [nucleotide binding]; other site 663278000481 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 663278000482 active site 663278000483 uracil binding [chemical binding]; other site 663278000484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278000485 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 663278000486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278000487 FeS/SAM binding site; other site 663278000488 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 663278000489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000490 Walker A motif; other site 663278000491 ATP binding site [chemical binding]; other site 663278000492 Walker B motif; other site 663278000493 arginine finger; other site 663278000494 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 663278000495 hypothetical protein; Validated; Region: PRK00153 663278000496 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 663278000497 nudix motif; other site 663278000498 recombination protein RecR; Reviewed; Region: recR; PRK00076 663278000499 RecR protein; Region: RecR; pfam02132 663278000500 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 663278000501 putative active site [active] 663278000502 putative metal-binding site [ion binding]; other site 663278000503 tetramer interface [polypeptide binding]; other site 663278000504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278000505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278000506 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 663278000507 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 663278000508 active site 663278000509 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 663278000510 trimer interface [polypeptide binding]; other site 663278000511 active site 663278000512 G bulge; other site 663278000513 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 663278000514 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 663278000515 FMN binding site [chemical binding]; other site 663278000516 active site 663278000517 catalytic residues [active] 663278000518 substrate binding site [chemical binding]; other site 663278000519 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 663278000520 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 663278000521 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 663278000522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278000523 Walker A/P-loop; other site 663278000524 ATP binding site [chemical binding]; other site 663278000525 Q-loop/lid; other site 663278000526 ABC transporter signature motif; other site 663278000527 Walker B; other site 663278000528 D-loop; other site 663278000529 H-loop/switch region; other site 663278000530 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 663278000531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278000532 sequence-specific DNA binding site [nucleotide binding]; other site 663278000533 salt bridge; other site 663278000534 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 663278000535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000536 Walker A motif; other site 663278000537 ATP binding site [chemical binding]; other site 663278000538 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 663278000539 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 663278000540 PYR/PP interface [polypeptide binding]; other site 663278000541 dimer interface [polypeptide binding]; other site 663278000542 TPP binding site [chemical binding]; other site 663278000543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 663278000544 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 663278000545 TPP-binding site [chemical binding]; other site 663278000546 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 663278000547 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 663278000548 putative valine binding site [chemical binding]; other site 663278000549 dimer interface [polypeptide binding]; other site 663278000550 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 663278000551 ketol-acid reductoisomerase; Provisional; Region: PRK05479 663278000552 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 663278000553 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 663278000554 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 663278000555 metal binding site 2 [ion binding]; metal-binding site 663278000556 putative DNA binding helix; other site 663278000557 metal binding site 1 [ion binding]; metal-binding site 663278000558 dimer interface [polypeptide binding]; other site 663278000559 structural Zn2+ binding site [ion binding]; other site 663278000560 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 663278000561 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 663278000562 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 663278000563 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 663278000564 active site 663278000565 dimer interface [polypeptide binding]; other site 663278000566 motif 1; other site 663278000567 motif 2; other site 663278000568 motif 3; other site 663278000569 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 663278000570 anticodon binding site; other site 663278000571 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 663278000572 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 663278000573 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 663278000574 AIR carboxylase; Region: AIRC; pfam00731 663278000575 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 663278000576 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 663278000577 ATP binding site [chemical binding]; other site 663278000578 active site 663278000579 substrate binding site [chemical binding]; other site 663278000580 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 663278000581 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 663278000582 active site 663278000583 tetramer interface [polypeptide binding]; other site 663278000584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278000585 active site 663278000586 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 663278000587 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 663278000588 dimerization interface [polypeptide binding]; other site 663278000589 putative ATP binding site [chemical binding]; other site 663278000590 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 663278000591 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 663278000592 active site 663278000593 substrate binding site [chemical binding]; other site 663278000594 cosubstrate binding site; other site 663278000595 catalytic site [active] 663278000596 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 663278000597 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 663278000598 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278000599 active site 663278000600 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 663278000601 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 663278000602 active site 663278000603 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 663278000604 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 663278000605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 663278000606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278000607 Coenzyme A binding pocket [chemical binding]; other site 663278000608 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 663278000609 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 663278000610 purine monophosphate binding site [chemical binding]; other site 663278000611 dimer interface [polypeptide binding]; other site 663278000612 putative catalytic residues [active] 663278000613 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 663278000614 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 663278000615 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 663278000616 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 663278000617 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 663278000618 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 663278000619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278000620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278000621 non-specific DNA binding site [nucleotide binding]; other site 663278000622 salt bridge; other site 663278000623 sequence-specific DNA binding site [nucleotide binding]; other site 663278000624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 663278000625 catalytic core [active] 663278000626 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 663278000627 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 663278000628 ssDNA binding site; other site 663278000629 generic binding surface II; other site 663278000630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278000631 ATP binding site [chemical binding]; other site 663278000632 putative Mg++ binding site [ion binding]; other site 663278000633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278000634 nucleotide binding region [chemical binding]; other site 663278000635 ATP-binding site [chemical binding]; other site 663278000636 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 663278000637 DAK2 domain; Region: Dak2; pfam02734 663278000638 Asp23 family; Region: Asp23; pfam03780 663278000639 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 663278000640 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 663278000641 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 663278000642 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 663278000643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278000644 putative active site [active] 663278000645 metal binding site [ion binding]; metal-binding site 663278000646 homodimer binding site [polypeptide binding]; other site 663278000647 phosphodiesterase; Provisional; Region: PRK12704 663278000648 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278000649 Zn2+ binding site [ion binding]; other site 663278000650 Mg2+ binding site [ion binding]; other site 663278000651 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 663278000652 Clp amino terminal domain; Region: Clp_N; pfam02861 663278000653 Clp amino terminal domain; Region: Clp_N; pfam02861 663278000654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000655 Walker A motif; other site 663278000656 ATP binding site [chemical binding]; other site 663278000657 Walker B motif; other site 663278000658 arginine finger; other site 663278000659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278000660 Walker A motif; other site 663278000661 ATP binding site [chemical binding]; other site 663278000662 Walker B motif; other site 663278000663 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 663278000664 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 663278000665 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 663278000666 ADP binding site [chemical binding]; other site 663278000667 phosphagen binding site; other site 663278000668 substrate specificity loop; other site 663278000669 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 663278000670 UvrB/uvrC motif; Region: UVR; pfam02151 663278000671 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 663278000672 Uncharacterized conserved protein [Function unknown]; Region: COG1434 663278000673 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 663278000674 putative active site [active] 663278000675 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 663278000676 Zn binding site [ion binding]; other site 663278000677 elongation factor P; Validated; Region: PRK00529 663278000678 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 663278000679 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 663278000680 RNA binding site [nucleotide binding]; other site 663278000681 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 663278000682 RNA binding site [nucleotide binding]; other site 663278000683 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 663278000684 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 663278000685 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 663278000686 active site 663278000687 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 663278000688 Dehydroquinase class II; Region: DHquinase_II; pfam01220 663278000689 active site 663278000690 trimer interface [polypeptide binding]; other site 663278000691 dimer interface [polypeptide binding]; other site 663278000692 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 663278000693 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 663278000694 Metal-binding active site; metal-binding site 663278000695 AP (apurinic/apyrimidinic) site pocket; other site 663278000696 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 663278000697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278000698 active site 663278000699 motif I; other site 663278000700 motif II; other site 663278000701 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 663278000702 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 663278000703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 663278000704 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 663278000705 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 663278000706 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 663278000707 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 663278000708 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 663278000709 active site 663278000710 Zn binding site [ion binding]; other site 663278000711 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 663278000712 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 663278000713 active site 663278000714 Zn binding site [ion binding]; other site 663278000715 Predicted membrane protein [Function unknown]; Region: COG2119 663278000716 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 663278000717 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 663278000718 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 663278000719 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 663278000720 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 663278000721 active site 663278000722 dimer interface [polypeptide binding]; other site 663278000723 effector binding site; other site 663278000724 TSCPD domain; Region: TSCPD; pfam12637 663278000725 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 663278000726 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 663278000727 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 663278000728 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 663278000729 TPP-binding site [chemical binding]; other site 663278000730 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 663278000731 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 663278000732 dimer interface [polypeptide binding]; other site 663278000733 PYR/PP interface [polypeptide binding]; other site 663278000734 TPP binding site [chemical binding]; other site 663278000735 substrate binding site [chemical binding]; other site 663278000736 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 663278000737 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 663278000738 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278000739 P-loop; other site 663278000740 Magnesium ion binding site [ion binding]; other site 663278000741 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 663278000742 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 663278000743 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 663278000744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278000745 Coenzyme A binding pocket [chemical binding]; other site 663278000746 SWIM zinc finger; Region: SWIM; pfam04434 663278000747 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 663278000748 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 663278000749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278000750 ATP binding site [chemical binding]; other site 663278000751 putative Mg++ binding site [ion binding]; other site 663278000752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278000753 nucleotide binding region [chemical binding]; other site 663278000754 ATP-binding site [chemical binding]; other site 663278000755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 663278000756 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 663278000757 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 663278000758 Mg++ binding site [ion binding]; other site 663278000759 putative catalytic motif [active] 663278000760 substrate binding site [chemical binding]; other site 663278000761 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 663278000762 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 663278000763 active site 663278000764 HIGH motif; other site 663278000765 dimer interface [polypeptide binding]; other site 663278000766 KMSKS motif; other site 663278000767 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 663278000768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278000769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278000770 homodimer interface [polypeptide binding]; other site 663278000771 catalytic residue [active] 663278000772 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 663278000773 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 663278000774 active site 663278000775 HIGH motif; other site 663278000776 KMSKS motif; other site 663278000777 PBP superfamily domain; Region: PBP_like_2; cl17296 663278000778 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 663278000779 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 663278000780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278000781 dimer interface [polypeptide binding]; other site 663278000782 conserved gate region; other site 663278000783 putative PBP binding loops; other site 663278000784 ABC-ATPase subunit interface; other site 663278000785 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 663278000786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278000787 dimer interface [polypeptide binding]; other site 663278000788 conserved gate region; other site 663278000789 putative PBP binding loops; other site 663278000790 ABC-ATPase subunit interface; other site 663278000791 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 663278000792 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 663278000793 Walker A/P-loop; other site 663278000794 ATP binding site [chemical binding]; other site 663278000795 Q-loop/lid; other site 663278000796 ABC transporter signature motif; other site 663278000797 Walker B; other site 663278000798 D-loop; other site 663278000799 H-loop/switch region; other site 663278000800 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 663278000801 PhoU domain; Region: PhoU; pfam01895 663278000802 PhoU domain; Region: PhoU; pfam01895 663278000803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278000804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278000805 active site 663278000806 phosphorylation site [posttranslational modification] 663278000807 intermolecular recognition site; other site 663278000808 dimerization interface [polypeptide binding]; other site 663278000809 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278000810 DNA binding site [nucleotide binding] 663278000811 PAS domain; Region: PAS; smart00091 663278000812 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 663278000813 putative active site [active] 663278000814 heme pocket [chemical binding]; other site 663278000815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278000816 dimer interface [polypeptide binding]; other site 663278000817 phosphorylation site [posttranslational modification] 663278000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278000819 ATP binding site [chemical binding]; other site 663278000820 Mg2+ binding site [ion binding]; other site 663278000821 G-X-G motif; other site 663278000822 Acylphosphatase; Region: Acylphosphatase; pfam00708 663278000823 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 663278000824 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 663278000825 homodimer interface [polypeptide binding]; other site 663278000826 substrate-cofactor binding pocket; other site 663278000827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278000828 catalytic residue [active] 663278000829 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 663278000830 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 663278000831 Ligand Binding Site [chemical binding]; other site 663278000832 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 663278000833 Domain of unknown function DUF20; Region: UPF0118; pfam01594 663278000834 Coat F domain; Region: Coat_F; pfam07875 663278000835 Predicted membrane protein [Function unknown]; Region: COG2246 663278000836 GtrA-like protein; Region: GtrA; pfam04138 663278000837 FkbH-like domain; Region: FkbH; TIGR01686 663278000838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278000839 active site 663278000840 motif I; other site 663278000841 motif II; other site 663278000842 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 663278000843 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 663278000844 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 663278000845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 663278000846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 663278000847 active site 663278000848 acyl carrier protein; Provisional; Region: PRK07081 663278000849 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 663278000850 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278000851 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278000852 Walker A/P-loop; other site 663278000853 ATP binding site [chemical binding]; other site 663278000854 Q-loop/lid; other site 663278000855 ABC transporter signature motif; other site 663278000856 Walker B; other site 663278000857 D-loop; other site 663278000858 H-loop/switch region; other site 663278000859 FtsX-like permease family; Region: FtsX; pfam02687 663278000860 FtsX-like permease family; Region: FtsX; pfam02687 663278000861 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 663278000862 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 663278000863 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 663278000864 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 663278000865 active site 663278000866 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 663278000867 putative NADP binding site [chemical binding]; other site 663278000868 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 663278000869 active site 663278000870 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 663278000871 Condensation domain; Region: Condensation; pfam00668 663278000872 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 663278000873 Nonribosomal peptide synthase; Region: NRPS; pfam08415 663278000874 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 663278000875 acyl-activating enzyme (AAE) consensus motif; other site 663278000876 AMP binding site [chemical binding]; other site 663278000877 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 663278000878 Condensation domain; Region: Condensation; pfam00668 663278000879 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 663278000880 Nonribosomal peptide synthase; Region: NRPS; pfam08415 663278000881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 663278000882 acyl-activating enzyme (AAE) consensus motif; other site 663278000883 active site 663278000884 AMP binding site [chemical binding]; other site 663278000885 CoA binding site [chemical binding]; other site 663278000886 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 663278000887 putative FMN binding site [chemical binding]; other site 663278000888 NADPH bind site [chemical binding]; other site 663278000889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 663278000890 AMP binding site [chemical binding]; other site 663278000891 active site 663278000892 CoA binding site [chemical binding]; other site 663278000893 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 663278000894 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 663278000895 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 663278000896 active site 663278000897 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 663278000898 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 663278000899 putative NADP binding site [chemical binding]; other site 663278000900 active site 663278000901 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 663278000902 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 663278000903 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 663278000904 acyl-activating enzyme (AAE) consensus motif; other site 663278000905 AMP binding site [chemical binding]; other site 663278000906 active site 663278000907 CoA binding site [chemical binding]; other site 663278000908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 663278000909 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 663278000910 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 663278000911 active site 663278000912 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 663278000913 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278000914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278000915 Walker A/P-loop; other site 663278000916 ATP binding site [chemical binding]; other site 663278000917 Q-loop/lid; other site 663278000918 ABC transporter signature motif; other site 663278000919 Walker B; other site 663278000920 D-loop; other site 663278000921 H-loop/switch region; other site 663278000922 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 663278000923 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 663278000924 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 663278000925 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 663278000926 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 663278000927 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 663278000928 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 663278000929 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 663278000930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 663278000931 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 663278000932 active site 663278000933 SpoVA protein; Region: SpoVA; cl04298 663278000934 stage V sporulation protein AD; Validated; Region: PRK08304 663278000935 stage V sporulation protein AD; Provisional; Region: PRK12404 663278000936 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 663278000937 Double zinc ribbon; Region: DZR; pfam12773 663278000938 TM2 domain; Region: TM2; cl00984 663278000939 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 663278000940 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 663278000941 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 663278000942 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 663278000943 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 663278000944 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 663278000945 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 663278000946 Walker A/P-loop; other site 663278000947 ATP binding site [chemical binding]; other site 663278000948 Q-loop/lid; other site 663278000949 ABC transporter signature motif; other site 663278000950 Walker B; other site 663278000951 D-loop; other site 663278000952 H-loop/switch region; other site 663278000953 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 663278000954 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 663278000955 dimer interface [polypeptide binding]; other site 663278000956 anticodon binding site; other site 663278000957 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 663278000958 homodimer interface [polypeptide binding]; other site 663278000959 motif 1; other site 663278000960 active site 663278000961 motif 2; other site 663278000962 GAD domain; Region: GAD; pfam02938 663278000963 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 663278000964 active site 663278000965 motif 3; other site 663278000966 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 663278000967 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 663278000968 dimer interface [polypeptide binding]; other site 663278000969 motif 1; other site 663278000970 active site 663278000971 motif 2; other site 663278000972 motif 3; other site 663278000973 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 663278000974 anticodon binding site; other site 663278000975 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 663278000976 active site 663278000977 dimer interfaces [polypeptide binding]; other site 663278000978 catalytic residues [active] 663278000979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 663278000980 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 663278000981 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 663278000982 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 663278000983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 663278000984 rod shape-determining protein MreC; Provisional; Region: PRK13922 663278000985 rod shape-determining protein MreC; Region: MreC; pfam04085 663278000986 rod shape-determining protein MreB; Provisional; Region: PRK13927 663278000987 MreB and similar proteins; Region: MreB_like; cd10225 663278000988 nucleotide binding site [chemical binding]; other site 663278000989 Mg binding site [ion binding]; other site 663278000990 putative protofilament interaction site [polypeptide binding]; other site 663278000991 RodZ interaction site [polypeptide binding]; other site 663278000992 stage V sporulation protein T; Region: spore_V_T; TIGR02851 663278000993 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 663278000994 Cell division protein ZapA; Region: ZapA; pfam05164 663278000995 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 663278000996 Peptidase family U32; Region: Peptidase_U32; pfam01136 663278000997 Collagenase; Region: DUF3656; pfam12392 663278000998 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 663278000999 trimer interface [polypeptide binding]; other site 663278001000 active site 663278001001 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 663278001002 peroxiredoxin; Region: AhpC; TIGR03137 663278001003 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 663278001004 dimer interface [polypeptide binding]; other site 663278001005 decamer (pentamer of dimers) interface [polypeptide binding]; other site 663278001006 catalytic triad [active] 663278001007 peroxidatic and resolving cysteines [active] 663278001008 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278001009 active site 663278001010 metal binding site [ion binding]; metal-binding site 663278001011 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278001012 YibE/F-like protein; Region: YibE_F; pfam07907 663278001013 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 663278001014 active site 663278001015 catalytic site [active] 663278001016 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 663278001017 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 663278001018 domain interfaces; other site 663278001019 active site 663278001020 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 663278001021 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 663278001022 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 663278001023 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 663278001024 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 663278001025 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 663278001026 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 663278001027 23S rRNA binding site [nucleotide binding]; other site 663278001028 L21 binding site [polypeptide binding]; other site 663278001029 L13 binding site [polypeptide binding]; other site 663278001030 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 663278001031 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 663278001032 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 663278001033 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 663278001034 DNA protecting protein DprA; Region: dprA; TIGR00732 663278001035 DNA topoisomerase I; Validated; Region: PRK05582 663278001036 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 663278001037 active site 663278001038 interdomain interaction site; other site 663278001039 putative metal-binding site [ion binding]; other site 663278001040 nucleotide binding site [chemical binding]; other site 663278001041 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 663278001042 domain I; other site 663278001043 DNA binding groove [nucleotide binding] 663278001044 phosphate binding site [ion binding]; other site 663278001045 domain II; other site 663278001046 domain III; other site 663278001047 nucleotide binding site [chemical binding]; other site 663278001048 catalytic site [active] 663278001049 domain IV; other site 663278001050 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 663278001051 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713 663278001052 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 663278001053 Glucose inhibited division protein A; Region: GIDA; pfam01134 663278001054 putative phosphate acyltransferase; Provisional; Region: PRK05331 663278001055 Phosphopantetheine attachment site; Region: PP-binding; cl09936 663278001056 ribonuclease III; Reviewed; Region: rnc; PRK00102 663278001057 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 663278001058 dimerization interface [polypeptide binding]; other site 663278001059 active site 663278001060 metal binding site [ion binding]; metal-binding site 663278001061 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 663278001062 dsRNA binding site [nucleotide binding]; other site 663278001063 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 663278001064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278001065 FeS/SAM binding site; other site 663278001066 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 663278001067 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 663278001068 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 663278001069 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 663278001070 Walker A/P-loop; other site 663278001071 ATP binding site [chemical binding]; other site 663278001072 Q-loop/lid; other site 663278001073 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 663278001074 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 663278001075 ABC transporter signature motif; other site 663278001076 Walker B; other site 663278001077 D-loop; other site 663278001078 H-loop/switch region; other site 663278001079 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 663278001080 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 663278001081 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 663278001082 P loop; other site 663278001083 GTP binding site [chemical binding]; other site 663278001084 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 663278001085 active site 663278001086 dimerization interface [polypeptide binding]; other site 663278001087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 663278001088 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 663278001089 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 663278001090 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 663278001091 active site 663278001092 (T/H)XGH motif; other site 663278001093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278001094 Zn2+ binding site [ion binding]; other site 663278001095 Mg2+ binding site [ion binding]; other site 663278001096 Oligomerisation domain; Region: Oligomerisation; pfam02410 663278001097 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 663278001098 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 663278001099 HIGH motif; other site 663278001100 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 663278001101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 663278001102 active site 663278001103 KMSKS motif; other site 663278001104 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 663278001105 tRNA binding surface [nucleotide binding]; other site 663278001106 FtsX-like permease family; Region: FtsX; pfam02687 663278001107 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278001108 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278001109 Walker A/P-loop; other site 663278001110 ATP binding site [chemical binding]; other site 663278001111 Q-loop/lid; other site 663278001112 ABC transporter signature motif; other site 663278001113 Walker B; other site 663278001114 D-loop; other site 663278001115 H-loop/switch region; other site 663278001116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278001117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 663278001118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278001119 dimer interface [polypeptide binding]; other site 663278001120 phosphorylation site [posttranslational modification] 663278001121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278001122 ATP binding site [chemical binding]; other site 663278001123 Mg2+ binding site [ion binding]; other site 663278001124 G-X-G motif; other site 663278001125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278001126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278001127 active site 663278001128 phosphorylation site [posttranslational modification] 663278001129 intermolecular recognition site; other site 663278001130 dimerization interface [polypeptide binding]; other site 663278001131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278001132 DNA binding site [nucleotide binding] 663278001133 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 663278001134 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 663278001135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278001136 catalytic residue [active] 663278001137 Protein of unknown function DUF111; Region: DUF111; pfam01969 663278001138 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 663278001139 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 663278001140 putative dimer interface [polypeptide binding]; other site 663278001141 putative anticodon binding site; other site 663278001142 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 663278001143 motif 1; other site 663278001144 dimer interface [polypeptide binding]; other site 663278001145 active site 663278001146 motif 2; other site 663278001147 motif 3; other site 663278001148 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 663278001149 DHH family; Region: DHH; pfam01368 663278001150 DHHA1 domain; Region: DHHA1; pfam02272 663278001151 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 663278001152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278001153 Zn2+ binding site [ion binding]; other site 663278001154 Mg2+ binding site [ion binding]; other site 663278001155 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 663278001156 synthetase active site [active] 663278001157 NTP binding site [chemical binding]; other site 663278001158 metal binding site [ion binding]; metal-binding site 663278001159 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 663278001160 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 663278001161 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 663278001162 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 663278001163 putative active site [active] 663278001164 dimerization interface [polypeptide binding]; other site 663278001165 putative tRNAtyr binding site [nucleotide binding]; other site 663278001166 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 663278001167 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 663278001168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278001169 FeS/SAM binding site; other site 663278001170 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 663278001171 active site 663278001172 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 663278001173 Double zinc ribbon; Region: DZR; pfam12773 663278001174 purine nucleoside phosphorylase; Provisional; Region: PRK08202 663278001175 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 663278001176 homodimer interface [polypeptide binding]; other site 663278001177 MazG family protein; Region: mazG; TIGR00444 663278001178 metal binding site [ion binding]; metal-binding site 663278001179 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 663278001180 IHF dimer interface [polypeptide binding]; other site 663278001181 IHF - DNA interface [nucleotide binding]; other site 663278001182 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278001183 RNA binding surface [nucleotide binding]; other site 663278001184 YabP family; Region: YabP; cl06766 663278001185 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 663278001186 Septum formation initiator; Region: DivIC; pfam04977 663278001187 hypothetical protein; Provisional; Region: PRK08582 663278001188 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 663278001189 RNA binding site [nucleotide binding]; other site 663278001190 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 663278001191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 663278001192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 663278001193 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 663278001194 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 663278001195 active site 663278001196 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 663278001197 30S subunit binding site; other site 663278001198 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 663278001199 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 663278001200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 663278001201 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 663278001202 oligomerisation interface [polypeptide binding]; other site 663278001203 mobile loop; other site 663278001204 roof hairpin; other site 663278001205 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 663278001206 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 663278001207 ring oligomerisation interface [polypeptide binding]; other site 663278001208 ATP/Mg binding site [chemical binding]; other site 663278001209 stacking interactions; other site 663278001210 hinge regions; other site 663278001211 prolyl-tRNA synthetase; Provisional; Region: PRK08661 663278001212 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 663278001213 dimer interface [polypeptide binding]; other site 663278001214 motif 1; other site 663278001215 active site 663278001216 motif 2; other site 663278001217 motif 3; other site 663278001218 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 663278001219 anticodon binding site; other site 663278001220 zinc-binding site [ion binding]; other site 663278001221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 663278001222 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 663278001223 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 663278001224 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 663278001225 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 663278001226 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 663278001227 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 663278001228 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 663278001229 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 663278001230 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 663278001231 putative translocon binding site; other site 663278001232 protein-rRNA interface [nucleotide binding]; other site 663278001233 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 663278001234 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 663278001235 G-X-X-G motif; other site 663278001236 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 663278001237 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 663278001238 23S rRNA interface [nucleotide binding]; other site 663278001239 5S rRNA interface [nucleotide binding]; other site 663278001240 putative antibiotic binding site [chemical binding]; other site 663278001241 L25 interface [polypeptide binding]; other site 663278001242 L27 interface [polypeptide binding]; other site 663278001243 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 663278001244 23S rRNA interface [nucleotide binding]; other site 663278001245 putative translocon interaction site; other site 663278001246 signal recognition particle (SRP54) interaction site; other site 663278001247 L23 interface [polypeptide binding]; other site 663278001248 trigger factor interaction site; other site 663278001249 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 663278001250 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 663278001251 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 663278001252 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 663278001253 RNA binding site [nucleotide binding]; other site 663278001254 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 663278001255 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 663278001256 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 663278001257 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 663278001258 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 663278001259 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 663278001260 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 663278001261 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 663278001262 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 663278001263 5S rRNA interface [nucleotide binding]; other site 663278001264 L27 interface [polypeptide binding]; other site 663278001265 23S rRNA interface [nucleotide binding]; other site 663278001266 L5 interface [polypeptide binding]; other site 663278001267 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 663278001268 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 663278001269 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 663278001270 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 663278001271 23S rRNA binding site [nucleotide binding]; other site 663278001272 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 663278001273 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 663278001274 SecY translocase; Region: SecY; pfam00344 663278001275 adenylate kinase; Reviewed; Region: adk; PRK00279 663278001276 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 663278001277 AMP-binding site [chemical binding]; other site 663278001278 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 663278001279 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 663278001280 active site 663278001281 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 663278001282 RNA binding site [nucleotide binding]; other site 663278001283 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 663278001284 rRNA binding site [nucleotide binding]; other site 663278001285 predicted 30S ribosome binding site; other site 663278001286 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 663278001287 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 663278001288 30S ribosomal protein S13; Region: bact_S13; TIGR03631 663278001289 30S ribosomal protein S11; Validated; Region: PRK05309 663278001290 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 663278001291 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 663278001292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278001293 RNA binding surface [nucleotide binding]; other site 663278001294 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 663278001295 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 663278001296 alphaNTD - beta interaction site [polypeptide binding]; other site 663278001297 alphaNTD homodimer interface [polypeptide binding]; other site 663278001298 alphaNTD - beta' interaction site [polypeptide binding]; other site 663278001299 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 663278001300 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 663278001301 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 663278001302 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 663278001303 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 663278001304 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 663278001305 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 663278001306 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 663278001307 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 663278001308 ANTAR domain; Region: ANTAR; pfam03861 663278001309 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 663278001310 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 663278001311 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278001312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278001313 Walker A/P-loop; other site 663278001314 ATP binding site [chemical binding]; other site 663278001315 Q-loop/lid; other site 663278001316 ABC transporter signature motif; other site 663278001317 Walker B; other site 663278001318 D-loop; other site 663278001319 H-loop/switch region; other site 663278001320 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 663278001321 ABC-2 type transporter; Region: ABC2_membrane; cl17235 663278001322 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 663278001323 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 663278001324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 663278001325 DNA binding residues [nucleotide binding] 663278001326 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 663278001327 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 663278001328 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 663278001329 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 663278001330 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 663278001331 Protein of unknown function DUF58; Region: DUF58; pfam01882 663278001332 MoxR-like ATPases [General function prediction only]; Region: COG0714 663278001333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278001334 Walker A motif; other site 663278001335 ATP binding site [chemical binding]; other site 663278001336 Walker B motif; other site 663278001337 arginine finger; other site 663278001338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 663278001339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 663278001340 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 663278001341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278001342 FeS/SAM binding site; other site 663278001343 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 663278001344 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 663278001345 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 663278001346 G1 box; other site 663278001347 putative GEF interaction site [polypeptide binding]; other site 663278001348 GTP/Mg2+ binding site [chemical binding]; other site 663278001349 Switch I region; other site 663278001350 G2 box; other site 663278001351 G3 box; other site 663278001352 Switch II region; other site 663278001353 G4 box; other site 663278001354 G5 box; other site 663278001355 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 663278001356 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 663278001357 MarR family; Region: MarR_2; cl17246 663278001358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 663278001359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278001360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278001361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278001362 Walker A/P-loop; other site 663278001363 ATP binding site [chemical binding]; other site 663278001364 Q-loop/lid; other site 663278001365 ABC transporter signature motif; other site 663278001366 Walker B; other site 663278001367 D-loop; other site 663278001368 H-loop/switch region; other site 663278001369 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278001370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278001371 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 663278001372 Walker A/P-loop; other site 663278001373 ATP binding site [chemical binding]; other site 663278001374 Q-loop/lid; other site 663278001375 ABC transporter signature motif; other site 663278001376 Walker B; other site 663278001377 D-loop; other site 663278001378 H-loop/switch region; other site 663278001379 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 663278001380 dimerization interface [polypeptide binding]; other site 663278001381 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 663278001382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 663278001383 dimer interface [polypeptide binding]; other site 663278001384 putative CheW interface [polypeptide binding]; other site 663278001385 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 663278001386 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 663278001387 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 663278001388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278001389 Walker A motif; other site 663278001390 ATP binding site [chemical binding]; other site 663278001391 Walker B motif; other site 663278001392 arginine finger; other site 663278001393 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 663278001394 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 663278001395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278001396 motif II; other site 663278001397 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 663278001398 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 663278001399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278001400 motif II; other site 663278001401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 663278001402 NAD(P) binding site [chemical binding]; other site 663278001403 active site 663278001404 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 663278001405 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 663278001406 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 663278001407 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 663278001408 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 663278001409 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 663278001410 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 663278001411 glutaminase active site [active] 663278001412 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 663278001413 dimer interface [polypeptide binding]; other site 663278001414 active site 663278001415 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 663278001416 dimer interface [polypeptide binding]; other site 663278001417 active site 663278001418 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 663278001419 Putative glucoamylase; Region: Glycoamylase; pfam10091 663278001420 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 663278001421 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 663278001422 Trp repressor protein; Region: Trp_repressor; cl17266 663278001423 Methyltransferase domain; Region: Methyltransf_31; pfam13847 663278001424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278001425 S-adenosylmethionine binding site [chemical binding]; other site 663278001426 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 663278001427 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 663278001428 dimerization interface [polypeptide binding]; other site 663278001429 domain crossover interface; other site 663278001430 redox-dependent activation switch; other site 663278001431 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 663278001432 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 663278001433 Cl- selectivity filter; other site 663278001434 Cl- binding residues [ion binding]; other site 663278001435 pore gating glutamate residue; other site 663278001436 dimer interface [polypeptide binding]; other site 663278001437 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278001438 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278001439 active site 663278001440 metal binding site [ion binding]; metal-binding site 663278001441 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 663278001442 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 663278001443 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 663278001444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278001445 catalytic residue [active] 663278001446 hypothetical protein; Reviewed; Region: PRK12497 663278001447 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 663278001448 RNA/DNA hybrid binding site [nucleotide binding]; other site 663278001449 active site 663278001450 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 663278001451 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 663278001452 GTP/Mg2+ binding site [chemical binding]; other site 663278001453 G4 box; other site 663278001454 G5 box; other site 663278001455 G1 box; other site 663278001456 Switch I region; other site 663278001457 G2 box; other site 663278001458 G3 box; other site 663278001459 Switch II region; other site 663278001460 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 663278001461 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 663278001462 Catalytic site [active] 663278001463 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 663278001464 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 663278001465 Catalytic site [active] 663278001466 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 663278001467 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 663278001468 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278001469 active site 663278001470 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 663278001471 putative active site [active] 663278001472 diaminopimelate decarboxylase; Region: lysA; TIGR01048 663278001473 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 663278001474 active site 663278001475 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 663278001476 substrate binding site [chemical binding]; other site 663278001477 catalytic residues [active] 663278001478 dimer interface [polypeptide binding]; other site 663278001479 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 663278001480 G1 box; other site 663278001481 GTP/Mg2+ binding site [chemical binding]; other site 663278001482 Switch I region; other site 663278001483 G2 box; other site 663278001484 G3 box; other site 663278001485 Switch II region; other site 663278001486 G4 box; other site 663278001487 G5 box; other site 663278001488 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 663278001489 Found in ATP-dependent protease La (LON); Region: LON; smart00464 663278001490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278001491 Walker A motif; other site 663278001492 ATP binding site [chemical binding]; other site 663278001493 Walker B motif; other site 663278001494 arginine finger; other site 663278001495 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 663278001496 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 663278001497 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 663278001498 dimer interface [polypeptide binding]; other site 663278001499 active site 663278001500 glycine-pyridoxal phosphate binding site [chemical binding]; other site 663278001501 folate binding site [chemical binding]; other site 663278001502 recombination factor protein RarA; Reviewed; Region: PRK13342 663278001503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278001504 Walker A motif; other site 663278001505 ATP binding site [chemical binding]; other site 663278001506 Walker B motif; other site 663278001507 arginine finger; other site 663278001508 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 663278001509 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 663278001510 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 663278001511 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 663278001512 active site 663278001513 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 663278001514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278001515 active site 663278001516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278001517 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 663278001518 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 663278001519 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 663278001520 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 663278001521 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 663278001522 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 663278001523 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 663278001524 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 663278001525 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 663278001526 active site 663278001527 homodimer interface [polypeptide binding]; other site 663278001528 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 663278001529 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 663278001530 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 663278001531 manganese transport protein MntH; Reviewed; Region: PRK00701 663278001532 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 663278001533 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 663278001534 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 663278001535 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 663278001536 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 663278001537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278001538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278001539 non-specific DNA binding site [nucleotide binding]; other site 663278001540 salt bridge; other site 663278001541 sequence-specific DNA binding site [nucleotide binding]; other site 663278001542 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 663278001543 Int/Topo IB signature motif; other site 663278001544 transcriptional repressor DicA; Reviewed; Region: PRK09706 663278001545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278001546 non-specific DNA binding site [nucleotide binding]; other site 663278001547 salt bridge; other site 663278001548 sequence-specific DNA binding site [nucleotide binding]; other site 663278001549 Helix-turn-helix domain; Region: HTH_17; cl17695 663278001550 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 663278001551 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278001552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278001553 non-specific DNA binding site [nucleotide binding]; other site 663278001554 salt bridge; other site 663278001555 sequence-specific DNA binding site [nucleotide binding]; other site 663278001556 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 663278001557 HsdM N-terminal domain; Region: HsdM_N; pfam12161 663278001558 Methyltransferase domain; Region: Methyltransf_26; pfam13659 663278001559 Virulence protein [General function prediction only]; Region: COG3943 663278001560 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 663278001561 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 663278001562 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 663278001563 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 663278001564 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 663278001565 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 663278001566 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 663278001567 active site 663278001568 DNA binding site [nucleotide binding] 663278001569 Int/Topo IB signature motif; other site 663278001570 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 663278001571 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 663278001572 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 663278001573 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 663278001574 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 663278001575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278001576 ATP binding site [chemical binding]; other site 663278001577 putative Mg++ binding site [ion binding]; other site 663278001578 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 663278001579 Mrr N-terminal domain; Region: Mrr_N; pfam14338 663278001580 Restriction endonuclease; Region: Mrr_cat; pfam04471 663278001581 multiple promoter invertase; Provisional; Region: mpi; PRK13413 663278001582 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 663278001583 catalytic residues [active] 663278001584 catalytic nucleophile [active] 663278001585 Presynaptic Site I dimer interface [polypeptide binding]; other site 663278001586 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 663278001587 Synaptic Flat tetramer interface [polypeptide binding]; other site 663278001588 Synaptic Site I dimer interface [polypeptide binding]; other site 663278001589 DNA binding site [nucleotide binding] 663278001590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278001591 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 663278001592 active site 663278001593 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 663278001594 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278001595 active site 663278001596 Phage tail protein; Region: Sipho_tail; cl17486 663278001597 tape measure domain; Region: tape_meas_nterm; TIGR02675 663278001598 Phage-related protein [Function unknown]; Region: COG5412 663278001599 Short C-terminal domain; Region: SHOCT; pfam09851 663278001600 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 663278001601 Minor capsid protein; Region: Minor_capsid_2; pfam11114 663278001602 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 663278001603 Phage capsid family; Region: Phage_capsid; pfam05065 663278001604 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 663278001605 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 663278001606 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 663278001607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 663278001608 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 663278001609 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 663278001610 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 663278001611 Mor transcription activator family; Region: Mor; cl02360 663278001612 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 663278001613 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 663278001614 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 663278001615 AAA domain; Region: AAA_22; pfam13401 663278001616 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 663278001617 Integrase core domain; Region: rve; pfam00665 663278001618 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 663278001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278001620 Walker A motif; other site 663278001621 ATP binding site [chemical binding]; other site 663278001622 Walker B motif; other site 663278001623 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 663278001624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278001625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278001626 non-specific DNA binding site [nucleotide binding]; other site 663278001627 salt bridge; other site 663278001628 sequence-specific DNA binding site [nucleotide binding]; other site 663278001629 Domain of unknown function (DUF955); Region: DUF955; pfam06114 663278001630 transposase/IS protein; Provisional; Region: PRK09183 663278001631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278001632 Walker A motif; other site 663278001633 ATP binding site [chemical binding]; other site 663278001634 Walker B motif; other site 663278001635 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278001636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278001637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278001638 DNA binding residues [nucleotide binding] 663278001639 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278001640 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 663278001641 Walker A/P-loop; other site 663278001642 ATP binding site [chemical binding]; other site 663278001643 Q-loop/lid; other site 663278001644 ABC transporter signature motif; other site 663278001645 Walker B; other site 663278001646 D-loop; other site 663278001647 H-loop/switch region; other site 663278001648 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 663278001649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 663278001650 DNA binding residues [nucleotide binding] 663278001651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278001652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 663278001653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 663278001654 RelB antitoxin; Region: RelB; cl01171 663278001655 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 663278001656 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 663278001657 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 663278001658 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 663278001659 FAD binding pocket [chemical binding]; other site 663278001660 FAD binding motif [chemical binding]; other site 663278001661 phosphate binding motif [ion binding]; other site 663278001662 beta-alpha-beta structure motif; other site 663278001663 NAD binding pocket [chemical binding]; other site 663278001664 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 663278001665 Short C-terminal domain; Region: SHOCT; pfam09851 663278001666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278001667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278001668 active site 663278001669 phosphorylation site [posttranslational modification] 663278001670 intermolecular recognition site; other site 663278001671 dimerization interface [polypeptide binding]; other site 663278001672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278001673 DNA binding site [nucleotide binding] 663278001674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278001675 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 663278001676 dimer interface [polypeptide binding]; other site 663278001677 phosphorylation site [posttranslational modification] 663278001678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278001679 ATP binding site [chemical binding]; other site 663278001680 Mg2+ binding site [ion binding]; other site 663278001681 G-X-G motif; other site 663278001682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 663278001683 classical (c) SDRs; Region: SDR_c; cd05233 663278001684 NAD(P) binding site [chemical binding]; other site 663278001685 active site 663278001686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 663278001687 short chain dehydrogenase; Provisional; Region: PRK07041 663278001688 NAD(P) binding site [chemical binding]; other site 663278001689 active site 663278001690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278001691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278001692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278001693 dimerization interface [polypeptide binding]; other site 663278001694 Predicted periplasmic protein [Function unknown]; Region: COG3698 663278001695 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 663278001696 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278001697 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278001698 active site 663278001699 metal binding site [ion binding]; metal-binding site 663278001700 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278001701 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278001702 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 663278001703 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 663278001704 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 663278001705 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278001706 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278001707 active site 663278001708 metal binding site [ion binding]; metal-binding site 663278001709 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 663278001710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278001711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 663278001712 Walker A/P-loop; other site 663278001713 ATP binding site [chemical binding]; other site 663278001714 Q-loop/lid; other site 663278001715 ABC transporter signature motif; other site 663278001716 Walker B; other site 663278001717 D-loop; other site 663278001718 H-loop/switch region; other site 663278001719 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 663278001720 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 663278001721 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 663278001722 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 663278001723 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 663278001724 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 663278001725 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 663278001726 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 663278001727 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 663278001728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278001729 conserved gate region; other site 663278001730 dimer interface [polypeptide binding]; other site 663278001731 putative PBP binding loops; other site 663278001732 ABC-ATPase subunit interface; other site 663278001733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278001734 dimer interface [polypeptide binding]; other site 663278001735 conserved gate region; other site 663278001736 putative PBP binding loops; other site 663278001737 ABC-ATPase subunit interface; other site 663278001738 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 663278001739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278001740 Walker A/P-loop; other site 663278001741 ATP binding site [chemical binding]; other site 663278001742 Q-loop/lid; other site 663278001743 ABC transporter signature motif; other site 663278001744 Walker B; other site 663278001745 D-loop; other site 663278001746 H-loop/switch region; other site 663278001747 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 663278001748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278001749 motif II; other site 663278001750 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 663278001751 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 663278001752 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278001753 dimerization domain swap beta strand [polypeptide binding]; other site 663278001754 regulatory protein interface [polypeptide binding]; other site 663278001755 active site 663278001756 regulatory phosphorylation site [posttranslational modification]; other site 663278001757 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 663278001758 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 663278001759 active site 663278001760 P-loop; other site 663278001761 phosphorylation site [posttranslational modification] 663278001762 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 663278001763 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 663278001764 active site 663278001765 phosphorylation site [posttranslational modification] 663278001766 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 663278001767 PRD domain; Region: PRD; pfam00874 663278001768 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 663278001769 active site 663278001770 P-loop; other site 663278001771 phosphorylation site [posttranslational modification] 663278001772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 663278001773 active site 663278001774 phosphorylation site [posttranslational modification] 663278001775 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 663278001776 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 663278001777 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 663278001778 P loop nucleotide binding; other site 663278001779 switch II; other site 663278001780 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 663278001781 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 663278001782 P loop nucleotide binding; other site 663278001783 switch II; other site 663278001784 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 663278001785 active site 663278001786 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 663278001787 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 663278001788 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 663278001789 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 663278001790 tetramerization interface [polypeptide binding]; other site 663278001791 NAD(P) binding site [chemical binding]; other site 663278001792 catalytic residues [active] 663278001793 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 663278001794 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 663278001795 inhibitor-cofactor binding pocket; inhibition site 663278001796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278001797 catalytic residue [active] 663278001798 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 663278001799 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 663278001800 putative active site [active] 663278001801 metal binding site [ion binding]; metal-binding site 663278001802 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278001803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278001804 non-specific DNA binding site [nucleotide binding]; other site 663278001805 salt bridge; other site 663278001806 sequence-specific DNA binding site [nucleotide binding]; other site 663278001807 Cupin domain; Region: Cupin_2; pfam07883 663278001808 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 663278001809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 663278001810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 663278001811 DNA binding residues [nucleotide binding] 663278001812 dimerization interface [polypeptide binding]; other site 663278001813 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 663278001814 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278001815 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 663278001816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278001817 Walker A/P-loop; other site 663278001818 ATP binding site [chemical binding]; other site 663278001819 Q-loop/lid; other site 663278001820 ABC transporter signature motif; other site 663278001821 Walker B; other site 663278001822 D-loop; other site 663278001823 H-loop/switch region; other site 663278001824 TOBE domain; Region: TOBE_2; pfam08402 663278001825 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 663278001826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278001827 dimer interface [polypeptide binding]; other site 663278001828 conserved gate region; other site 663278001829 putative PBP binding loops; other site 663278001830 ABC-ATPase subunit interface; other site 663278001831 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 663278001832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278001833 dimer interface [polypeptide binding]; other site 663278001834 conserved gate region; other site 663278001835 putative PBP binding loops; other site 663278001836 ABC-ATPase subunit interface; other site 663278001837 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 663278001838 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 663278001839 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 663278001840 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 663278001841 inhibitor-cofactor binding pocket; inhibition site 663278001842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278001843 catalytic residue [active] 663278001844 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278001845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278001846 active site 663278001847 phosphorylation site [posttranslational modification] 663278001848 intermolecular recognition site; other site 663278001849 dimerization interface [polypeptide binding]; other site 663278001850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278001851 DNA binding site [nucleotide binding] 663278001852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278001853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 663278001854 dimerization interface [polypeptide binding]; other site 663278001855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278001856 dimer interface [polypeptide binding]; other site 663278001857 phosphorylation site [posttranslational modification] 663278001858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278001859 ATP binding site [chemical binding]; other site 663278001860 Mg2+ binding site [ion binding]; other site 663278001861 G-X-G motif; other site 663278001862 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278001863 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278001864 Walker A/P-loop; other site 663278001865 ATP binding site [chemical binding]; other site 663278001866 Q-loop/lid; other site 663278001867 ABC transporter signature motif; other site 663278001868 Walker B; other site 663278001869 D-loop; other site 663278001870 H-loop/switch region; other site 663278001871 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278001872 FtsX-like permease family; Region: FtsX; pfam02687 663278001873 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278001874 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 663278001875 FtsX-like permease family; Region: FtsX; pfam02687 663278001876 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 663278001877 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278001878 dimerization domain swap beta strand [polypeptide binding]; other site 663278001879 regulatory protein interface [polypeptide binding]; other site 663278001880 active site 663278001881 regulatory phosphorylation site [posttranslational modification]; other site 663278001882 Predicted transcriptional regulators [Transcription]; Region: COG1725 663278001883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278001884 DNA-binding site [nucleotide binding]; DNA binding site 663278001885 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 663278001886 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 663278001887 Walker A/P-loop; other site 663278001888 ATP binding site [chemical binding]; other site 663278001889 Q-loop/lid; other site 663278001890 ABC transporter signature motif; other site 663278001891 Walker B; other site 663278001892 D-loop; other site 663278001893 H-loop/switch region; other site 663278001894 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278001895 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 663278001896 Walker A/P-loop; other site 663278001897 ATP binding site [chemical binding]; other site 663278001898 Q-loop/lid; other site 663278001899 ABC transporter signature motif; other site 663278001900 Walker B; other site 663278001901 D-loop; other site 663278001902 H-loop/switch region; other site 663278001903 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 663278001904 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 663278001905 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 663278001906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278001907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278001908 homodimer interface [polypeptide binding]; other site 663278001909 catalytic residue [active] 663278001910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 663278001911 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 663278001912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278001913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278001914 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 663278001915 putative dimerization interface [polypeptide binding]; other site 663278001916 Predicted membrane protein [Function unknown]; Region: COG2855 663278001917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 663278001918 active site residue [active] 663278001919 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 663278001920 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 663278001921 catalytic residues [active] 663278001922 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 663278001923 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 663278001924 catalytic nucleophile [active] 663278001925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278001926 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278001927 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278001928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278001929 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278001930 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278001931 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278001932 salicylate synthase; Region: salicyl_syn; TIGR03494 663278001933 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 663278001934 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 663278001935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 663278001936 acyl-activating enzyme (AAE) consensus motif; other site 663278001937 AMP binding site [chemical binding]; other site 663278001938 active site 663278001939 CoA binding site [chemical binding]; other site 663278001940 Phosphopantetheine attachment site; Region: PP-binding; cl09936 663278001941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278001942 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 663278001943 putative substrate translocation pore; other site 663278001944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 663278001945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 663278001946 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 663278001947 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 663278001948 NAD(P) binding site [chemical binding]; other site 663278001949 catalytic residues [active] 663278001950 Uncharacterized conserved protein [Function unknown]; Region: COG2006 663278001951 Domain of unknown function (DUF362); Region: DUF362; pfam04015 663278001952 Predicted transcriptional regulators [Transcription]; Region: COG1733 663278001953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278001954 dimerization interface [polypeptide binding]; other site 663278001955 putative DNA binding site [nucleotide binding]; other site 663278001956 putative Zn2+ binding site [ion binding]; other site 663278001957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278001958 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278001959 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278001960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278001961 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278001962 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278001963 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278001964 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 663278001965 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 663278001966 homopentamer interface [polypeptide binding]; other site 663278001967 active site 663278001968 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 663278001969 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 663278001970 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 663278001971 dimerization interface [polypeptide binding]; other site 663278001972 active site 663278001973 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 663278001974 Lumazine binding domain; Region: Lum_binding; pfam00677 663278001975 Lumazine binding domain; Region: Lum_binding; pfam00677 663278001976 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 663278001977 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 663278001978 catalytic motif [active] 663278001979 Zn binding site [ion binding]; other site 663278001980 RibD C-terminal domain; Region: RibD_C; cl17279 663278001981 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 663278001982 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 663278001983 LexA repressor; Validated; Region: PRK00215 663278001984 YibE/F-like protein; Region: YibE_F; pfam07907 663278001985 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 663278001986 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 663278001987 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 663278001988 Interdomain contacts; other site 663278001989 Cytokine receptor motif; other site 663278001990 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 663278001991 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 663278001992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278001993 active site 663278001994 metal binding site [ion binding]; metal-binding site 663278001995 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278001996 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 663278001997 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 663278001998 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 663278001999 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 663278002000 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 663278002001 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 663278002002 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 663278002003 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 663278002004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 663278002005 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 663278002006 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 663278002007 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 663278002008 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 663278002009 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 663278002010 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 663278002011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 663278002012 UDP-galactopyranose mutase; Region: GLF; pfam03275 663278002013 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 663278002014 active site 663278002015 intersubunit interactions; other site 663278002016 catalytic residue [active] 663278002017 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 663278002018 BioY family; Region: BioY; pfam02632 663278002019 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 663278002020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278002021 Zn2+ binding site [ion binding]; other site 663278002022 Mg2+ binding site [ion binding]; other site 663278002023 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278002024 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 663278002025 catalytic residues [active] 663278002026 catalytic nucleophile [active] 663278002027 Recombinase; Region: Recombinase; pfam07508 663278002028 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278002029 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 663278002030 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 663278002031 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 663278002032 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 663278002033 NAD(P) binding site [chemical binding]; other site 663278002034 homodimer interface [polypeptide binding]; other site 663278002035 substrate binding site [chemical binding]; other site 663278002036 active site 663278002037 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 663278002038 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 663278002039 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 663278002040 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 663278002041 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 663278002042 putative trimer interface [polypeptide binding]; other site 663278002043 putative CoA binding site [chemical binding]; other site 663278002044 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 663278002045 putative trimer interface [polypeptide binding]; other site 663278002046 putative active site [active] 663278002047 putative substrate binding site [chemical binding]; other site 663278002048 putative CoA binding site [chemical binding]; other site 663278002049 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 663278002050 active site 663278002051 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 663278002052 homodimer interface [polypeptide binding]; other site 663278002053 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 663278002054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 663278002055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 663278002056 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 663278002057 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 663278002058 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 663278002059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278002060 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278002061 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278002062 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 663278002063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278002064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278002065 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 663278002066 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 663278002067 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 663278002068 inhibitor-cofactor binding pocket; inhibition site 663278002069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278002070 catalytic residue [active] 663278002071 Bacterial sugar transferase; Region: Bac_transf; pfam02397 663278002072 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 663278002073 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 663278002074 tetrameric interface [polypeptide binding]; other site 663278002075 activator binding site; other site 663278002076 NADP binding site [chemical binding]; other site 663278002077 substrate binding site [chemical binding]; other site 663278002078 catalytic residues [active] 663278002079 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 663278002080 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 663278002081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 663278002082 NAD(P) binding site [chemical binding]; other site 663278002083 active site 663278002084 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 663278002085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278002086 Zn2+ binding site [ion binding]; other site 663278002087 Mg2+ binding site [ion binding]; other site 663278002088 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 663278002089 AAA domain; Region: AAA_14; pfam13173 663278002090 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 663278002091 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 663278002092 dimer interface [polypeptide binding]; other site 663278002093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278002094 catalytic residue [active] 663278002095 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 663278002096 homotrimer interaction site [polypeptide binding]; other site 663278002097 putative active site [active] 663278002098 Predicted transcriptional regulator [Transcription]; Region: COG1959 663278002099 Transcriptional regulator; Region: Rrf2; cl17282 663278002100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278002101 Zn2+ binding site [ion binding]; other site 663278002102 Mg2+ binding site [ion binding]; other site 663278002103 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 663278002104 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 663278002105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278002106 FeS/SAM binding site; other site 663278002107 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 663278002108 MutS domain I; Region: MutS_I; pfam01624 663278002109 MutS domain II; Region: MutS_II; pfam05188 663278002110 MutS domain III; Region: MutS_III; pfam05192 663278002111 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 663278002112 Walker A/P-loop; other site 663278002113 ATP binding site [chemical binding]; other site 663278002114 Q-loop/lid; other site 663278002115 ABC transporter signature motif; other site 663278002116 Walker B; other site 663278002117 D-loop; other site 663278002118 H-loop/switch region; other site 663278002119 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 663278002120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278002121 ATP binding site [chemical binding]; other site 663278002122 Mg2+ binding site [ion binding]; other site 663278002123 G-X-G motif; other site 663278002124 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 663278002125 ATP binding site [chemical binding]; other site 663278002126 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 663278002127 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 663278002128 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 663278002129 bacterial Hfq-like; Region: Hfq; cd01716 663278002130 hexamer interface [polypeptide binding]; other site 663278002131 Sm1 motif; other site 663278002132 RNA binding site [nucleotide binding]; other site 663278002133 Sm2 motif; other site 663278002134 HlyD family secretion protein; Region: HlyD_2; pfam12700 663278002135 putative membrane fusion protein; Region: TIGR02828 663278002136 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 663278002137 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 663278002138 catalytic residue [active] 663278002139 Protein of unknown function (DUF552); Region: DUF552; pfam04472 663278002140 YGGT family; Region: YGGT; pfam02325 663278002141 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 663278002142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278002143 RNA binding surface [nucleotide binding]; other site 663278002144 DivIVA protein; Region: DivIVA; pfam05103 663278002145 DivIVA domain; Region: DivI1A_domain; TIGR03544 663278002146 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 663278002147 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 663278002148 active site 663278002149 HIGH motif; other site 663278002150 nucleotide binding site [chemical binding]; other site 663278002151 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 663278002152 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 663278002153 active site 663278002154 KMSKS motif; other site 663278002155 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 663278002156 tRNA binding surface [nucleotide binding]; other site 663278002157 anticodon binding site; other site 663278002158 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 663278002159 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 663278002160 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 663278002161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278002162 RNA binding surface [nucleotide binding]; other site 663278002163 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 663278002164 active site 663278002165 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 663278002166 transketolase; Reviewed; Region: PRK05899 663278002167 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 663278002168 TPP-binding site [chemical binding]; other site 663278002169 dimer interface [polypeptide binding]; other site 663278002170 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 663278002171 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 663278002172 PYR/PP interface [polypeptide binding]; other site 663278002173 dimer interface [polypeptide binding]; other site 663278002174 TPP binding site [chemical binding]; other site 663278002175 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 663278002176 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 663278002177 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 663278002178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278002179 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 663278002180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278002181 motif II; other site 663278002182 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 663278002183 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 663278002184 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 663278002185 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 663278002186 homodimer interface [polypeptide binding]; other site 663278002187 substrate-cofactor binding pocket; other site 663278002188 catalytic residue [active] 663278002189 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 663278002190 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 663278002191 hinge; other site 663278002192 active site 663278002193 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 663278002194 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 663278002195 FOG: CBS domain [General function prediction only]; Region: COG0517 663278002196 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 663278002197 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 663278002198 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 663278002199 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 663278002200 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 663278002201 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 663278002202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278002203 active site 663278002204 phosphorylation site [posttranslational modification] 663278002205 intermolecular recognition site; other site 663278002206 dimerization interface [polypeptide binding]; other site 663278002207 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 663278002208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 663278002209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278002210 DNA-binding site [nucleotide binding]; DNA binding site 663278002211 TrkA-C domain; Region: TrkA_C; pfam02080 663278002212 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278002213 dimerization domain swap beta strand [polypeptide binding]; other site 663278002214 regulatory protein interface [polypeptide binding]; other site 663278002215 active site 663278002216 regulatory phosphorylation site [posttranslational modification]; other site 663278002217 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 663278002218 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 663278002219 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 663278002220 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 663278002221 CAT RNA binding domain; Region: CAT_RBD; smart01061 663278002222 PRD domain; Region: PRD; pfam00874 663278002223 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 663278002224 HPr interaction site; other site 663278002225 glycerol kinase (GK) interaction site [polypeptide binding]; other site 663278002226 active site 663278002227 phosphorylation site [posttranslational modification] 663278002228 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 663278002229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 663278002230 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 663278002231 active site turn [active] 663278002232 phosphorylation site [posttranslational modification] 663278002233 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 663278002234 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 663278002235 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 663278002236 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 663278002237 SpoVR like protein; Region: SpoVR; pfam04293 663278002238 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 663278002239 metal ion-dependent adhesion site (MIDAS); other site 663278002240 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 663278002241 AAA ATPase domain; Region: AAA_16; pfam13191 663278002242 AAA domain; Region: AAA_17; pfam13207 663278002243 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 663278002244 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 663278002245 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 663278002246 catalytic residue [active] 663278002247 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278002248 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278002249 active site 663278002250 metal binding site [ion binding]; metal-binding site 663278002251 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 663278002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278002253 catalytic residue [active] 663278002254 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 663278002255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 663278002256 dimer interface [polypeptide binding]; other site 663278002257 active site 663278002258 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 663278002259 catalytic residues [active] 663278002260 substrate binding site [chemical binding]; other site 663278002261 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 663278002262 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 663278002263 NAD(P) binding pocket [chemical binding]; other site 663278002264 spermidine synthase; Provisional; Region: PRK00811 663278002265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278002266 S-adenosylmethionine binding site [chemical binding]; other site 663278002267 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 663278002268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 663278002269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278002270 catalytic residue [active] 663278002271 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 663278002272 fumarate hydratase; Provisional; Region: PRK06246 663278002273 Fumarase C-terminus; Region: Fumerase_C; cl00795 663278002274 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 663278002275 Malic enzyme, N-terminal domain; Region: malic; pfam00390 663278002276 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 663278002277 putative NAD(P) binding site [chemical binding]; other site 663278002278 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 663278002279 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 663278002280 nucleotide binding site [chemical binding]; other site 663278002281 putative alpha-glucosidase; Provisional; Region: PRK10658 663278002282 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 663278002283 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 663278002284 trimer interface [polypeptide binding]; other site 663278002285 active site 663278002286 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 663278002287 catalytic site [active] 663278002288 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 663278002289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002290 dimer interface [polypeptide binding]; other site 663278002291 conserved gate region; other site 663278002292 putative PBP binding loops; other site 663278002293 ABC-ATPase subunit interface; other site 663278002294 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 663278002295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002296 dimer interface [polypeptide binding]; other site 663278002297 conserved gate region; other site 663278002298 putative PBP binding loops; other site 663278002299 ABC-ATPase subunit interface; other site 663278002300 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 663278002301 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 663278002302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 663278002303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 663278002304 DNA binding site [nucleotide binding] 663278002305 domain linker motif; other site 663278002306 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 663278002307 dimerization interface [polypeptide binding]; other site 663278002308 ligand binding site [chemical binding]; other site 663278002309 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 663278002310 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 663278002311 Ca binding site [ion binding]; other site 663278002312 active site 663278002313 catalytic site [active] 663278002314 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 663278002315 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 663278002316 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 663278002317 Ca binding site [ion binding]; other site 663278002318 active site 663278002319 catalytic site [active] 663278002320 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 663278002321 Protein of unknown function, DUF624; Region: DUF624; pfam04854 663278002322 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 663278002323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 663278002324 DNA binding site [nucleotide binding] 663278002325 domain linker motif; other site 663278002326 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 663278002327 putative dimerization interface [polypeptide binding]; other site 663278002328 putative ligand binding site [chemical binding]; other site 663278002329 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 663278002330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 663278002331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002332 dimer interface [polypeptide binding]; other site 663278002333 conserved gate region; other site 663278002334 putative PBP binding loops; other site 663278002335 ABC-ATPase subunit interface; other site 663278002336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 663278002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002338 dimer interface [polypeptide binding]; other site 663278002339 conserved gate region; other site 663278002340 putative PBP binding loops; other site 663278002341 ABC-ATPase subunit interface; other site 663278002342 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 663278002343 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 663278002344 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 663278002345 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 663278002346 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 663278002347 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 663278002348 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 663278002349 active site 663278002350 catalytic residues [active] 663278002351 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 663278002352 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 663278002353 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 663278002354 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 663278002355 dimer interface [polypeptide binding]; other site 663278002356 active site 663278002357 UDP-glucose 4-epimerase; Region: PLN02240 663278002358 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 663278002359 NAD binding site [chemical binding]; other site 663278002360 homodimer interface [polypeptide binding]; other site 663278002361 active site 663278002362 substrate binding site [chemical binding]; other site 663278002363 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 663278002364 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 663278002365 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 663278002366 glutamate racemase; Provisional; Region: PRK00865 663278002367 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 663278002368 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 663278002369 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 663278002370 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 663278002371 active site 663278002372 HIGH motif; other site 663278002373 KMSK motif region; other site 663278002374 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 663278002375 tRNA binding surface [nucleotide binding]; other site 663278002376 anticodon binding site; other site 663278002377 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 663278002378 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278002379 putative active site [active] 663278002380 putative metal binding site [ion binding]; other site 663278002381 Homoserine O-succinyltransferase; Region: HTS; pfam04204 663278002382 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 663278002383 proposed active site lysine [active] 663278002384 conserved cys residue [active] 663278002385 rod shape-determining protein MreB; Provisional; Region: PRK13930 663278002386 MreB and similar proteins; Region: MreB_like; cd10225 663278002387 nucleotide binding site [chemical binding]; other site 663278002388 Mg binding site [ion binding]; other site 663278002389 putative protofilament interaction site [polypeptide binding]; other site 663278002390 RodZ interaction site [polypeptide binding]; other site 663278002391 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 663278002392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278002393 active site 663278002394 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 663278002395 AAA domain; Region: AAA_30; pfam13604 663278002396 Family description; Region: UvrD_C_2; pfam13538 663278002397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 663278002398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278002399 Coenzyme A binding pocket [chemical binding]; other site 663278002400 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 663278002401 Peptidase family M23; Region: Peptidase_M23; pfam01551 663278002402 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 663278002403 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 663278002404 DNA binding residues [nucleotide binding] 663278002405 putative dimer interface [polypeptide binding]; other site 663278002406 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 663278002407 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 663278002408 Stage II sporulation protein; Region: SpoIID; pfam08486 663278002409 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 663278002410 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 663278002411 dimer interface [polypeptide binding]; other site 663278002412 Citrate synthase; Region: Citrate_synt; pfam00285 663278002413 active site 663278002414 citrylCoA binding site [chemical binding]; other site 663278002415 oxalacetate/citrate binding site [chemical binding]; other site 663278002416 coenzyme A binding site [chemical binding]; other site 663278002417 catalytic triad [active] 663278002418 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 663278002419 serine O-acetyltransferase; Region: cysE; TIGR01172 663278002420 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 663278002421 trimer interface [polypeptide binding]; other site 663278002422 active site 663278002423 substrate binding site [chemical binding]; other site 663278002424 CoA binding site [chemical binding]; other site 663278002425 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 663278002426 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 663278002427 active site 663278002428 HIGH motif; other site 663278002429 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 663278002430 KMSKS motif; other site 663278002431 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 663278002432 tRNA binding surface [nucleotide binding]; other site 663278002433 anticodon binding site; other site 663278002434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278002435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278002436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278002437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 663278002438 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 663278002439 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 663278002440 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 663278002441 tetramer (dimer of dimers) interface [polypeptide binding]; other site 663278002442 active site 663278002443 dimer interface [polypeptide binding]; other site 663278002444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 663278002445 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 663278002446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278002447 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 663278002448 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278002449 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 663278002450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278002451 dimerization interface [polypeptide binding]; other site 663278002452 putative DNA binding site [nucleotide binding]; other site 663278002453 putative Zn2+ binding site [ion binding]; other site 663278002454 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 663278002455 Predicted integral membrane protein [Function unknown]; Region: COG5658 663278002456 SdpI/YhfL protein family; Region: SdpI; pfam13630 663278002457 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 663278002458 active site 663278002459 catalytic triad [active] 663278002460 oxyanion hole [active] 663278002461 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 663278002462 ApbE family; Region: ApbE; pfam02424 663278002463 4Fe-4S binding domain; Region: Fer4_5; pfam12801 663278002464 4Fe-4S binding domain; Region: Fer4_5; pfam12801 663278002465 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 663278002466 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 663278002467 FMN-binding domain; Region: FMN_bind; cl01081 663278002468 Uncharacterized conserved protein [Function unknown]; Region: COG1633 663278002469 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 663278002470 dinuclear metal binding motif [ion binding]; other site 663278002471 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 663278002472 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 663278002473 Walker A/P-loop; other site 663278002474 ATP binding site [chemical binding]; other site 663278002475 Q-loop/lid; other site 663278002476 ABC transporter signature motif; other site 663278002477 Walker B; other site 663278002478 D-loop; other site 663278002479 H-loop/switch region; other site 663278002480 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 663278002481 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 663278002482 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 663278002483 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 663278002484 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 663278002485 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 663278002486 Walker A motif; other site 663278002487 ATP binding site [chemical binding]; other site 663278002488 Walker B motif; other site 663278002489 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 663278002490 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278002491 Walker A motif; other site 663278002492 ATP binding site [chemical binding]; other site 663278002493 Walker B motif; other site 663278002494 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 663278002495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278002496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278002497 DNA binding residues [nucleotide binding] 663278002498 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 663278002499 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 663278002500 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 663278002501 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 663278002502 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 663278002503 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 663278002504 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 663278002505 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 663278002506 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 663278002507 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 663278002508 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 663278002509 Walker A/P-loop; other site 663278002510 ATP binding site [chemical binding]; other site 663278002511 Q-loop/lid; other site 663278002512 ABC transporter signature motif; other site 663278002513 Walker B; other site 663278002514 D-loop; other site 663278002515 H-loop/switch region; other site 663278002516 UDP-glucose 4-epimerase; Region: PLN02240 663278002517 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 663278002518 NAD binding site [chemical binding]; other site 663278002519 homodimer interface [polypeptide binding]; other site 663278002520 active site 663278002521 substrate binding site [chemical binding]; other site 663278002522 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 663278002523 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 663278002524 putative ligand binding site [chemical binding]; other site 663278002525 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 663278002526 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 663278002527 Walker A/P-loop; other site 663278002528 ATP binding site [chemical binding]; other site 663278002529 Q-loop/lid; other site 663278002530 ABC transporter signature motif; other site 663278002531 Walker B; other site 663278002532 D-loop; other site 663278002533 H-loop/switch region; other site 663278002534 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 663278002535 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 663278002536 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 663278002537 TM-ABC transporter signature motif; other site 663278002538 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 663278002539 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 663278002540 TM-ABC transporter signature motif; other site 663278002541 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 663278002542 trimer interface [polypeptide binding]; other site 663278002543 active site 663278002544 substrate binding site [chemical binding]; other site 663278002545 CoA binding site [chemical binding]; other site 663278002546 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 663278002547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278002548 dimerization interface [polypeptide binding]; other site 663278002549 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 663278002550 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 663278002551 dimer interface [polypeptide binding]; other site 663278002552 putative CheW interface [polypeptide binding]; other site 663278002553 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 663278002554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278002555 active site 663278002556 motif I; other site 663278002557 motif II; other site 663278002558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278002559 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 663278002560 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 663278002561 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 663278002562 active site 663278002563 phosphorylation site [posttranslational modification] 663278002564 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 663278002565 active pocket/dimerization site; other site 663278002566 active site 663278002567 phosphorylation site [posttranslational modification] 663278002568 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 663278002569 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 663278002570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 663278002571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 663278002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278002573 active site 663278002574 phosphorylation site [posttranslational modification] 663278002575 intermolecular recognition site; other site 663278002576 dimerization interface [polypeptide binding]; other site 663278002577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 663278002578 DNA binding residues [nucleotide binding] 663278002579 dimerization interface [polypeptide binding]; other site 663278002580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 663278002581 Histidine kinase; Region: HisKA_3; pfam07730 663278002582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278002583 ATP binding site [chemical binding]; other site 663278002584 Mg2+ binding site [ion binding]; other site 663278002585 G-X-G motif; other site 663278002586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 663278002587 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 663278002588 ligand binding site [chemical binding]; other site 663278002589 Predicted membrane protein [Function unknown]; Region: COG1971 663278002590 Domain of unknown function DUF; Region: DUF204; pfam02659 663278002591 Domain of unknown function DUF; Region: DUF204; pfam02659 663278002592 AAA domain; Region: AAA_33; pfam13671 663278002593 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 663278002594 active site 663278002595 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 663278002596 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 663278002597 substrate binding [chemical binding]; other site 663278002598 active site 663278002599 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 663278002600 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 663278002601 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 663278002602 active site turn [active] 663278002603 phosphorylation site [posttranslational modification] 663278002604 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 663278002605 Transcriptional regulators [Transcription]; Region: PurR; COG1609 663278002606 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 663278002607 DNA binding site [nucleotide binding] 663278002608 domain linker motif; other site 663278002609 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 663278002610 dimerization interface [polypeptide binding]; other site 663278002611 ligand binding site [chemical binding]; other site 663278002612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 663278002613 binding surface 663278002614 TPR motif; other site 663278002615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 663278002616 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278002617 active site 663278002618 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 663278002619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278002620 motif II; other site 663278002621 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 663278002622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278002623 non-specific DNA binding site [nucleotide binding]; other site 663278002624 salt bridge; other site 663278002625 sequence-specific DNA binding site [nucleotide binding]; other site 663278002626 Cupin domain; Region: Cupin_2; pfam07883 663278002627 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 663278002628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 663278002629 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 663278002630 active site 663278002631 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 663278002632 dimerization interface [polypeptide binding]; other site 663278002633 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 663278002634 putative active cleft [active] 663278002635 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 663278002636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 663278002637 nucleotide binding site [chemical binding]; other site 663278002638 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 663278002639 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 663278002640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278002641 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 663278002642 active site 663278002643 motif I; other site 663278002644 motif II; other site 663278002645 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 663278002646 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 663278002647 beta-galactosidase; Region: BGL; TIGR03356 663278002648 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 663278002649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278002650 DNA-binding site [nucleotide binding]; DNA binding site 663278002651 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 663278002652 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 663278002653 beta-galactosidase; Region: BGL; TIGR03356 663278002654 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 663278002655 methionine cluster; other site 663278002656 active site 663278002657 phosphorylation site [posttranslational modification] 663278002658 metal binding site [ion binding]; metal-binding site 663278002659 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 663278002660 active site 663278002661 P-loop; other site 663278002662 phosphorylation site [posttranslational modification] 663278002663 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 663278002664 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 663278002665 CrcB-like protein; Region: CRCB; cl09114 663278002666 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 663278002667 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 663278002668 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 663278002669 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 663278002670 intersubunit interface [polypeptide binding]; other site 663278002671 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 663278002672 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 663278002673 Walker A/P-loop; other site 663278002674 ATP binding site [chemical binding]; other site 663278002675 Q-loop/lid; other site 663278002676 ABC transporter signature motif; other site 663278002677 Walker B; other site 663278002678 D-loop; other site 663278002679 H-loop/switch region; other site 663278002680 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 663278002681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 663278002682 ABC-ATPase subunit interface; other site 663278002683 dimer interface [polypeptide binding]; other site 663278002684 putative PBP binding regions; other site 663278002685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278002686 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 663278002687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278002688 FeS/SAM binding site; other site 663278002689 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 663278002690 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 663278002691 MPT binding site; other site 663278002692 trimer interface [polypeptide binding]; other site 663278002693 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 663278002694 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 663278002695 dimer interface [polypeptide binding]; other site 663278002696 putative functional site; other site 663278002697 putative MPT binding site; other site 663278002698 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 663278002699 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 663278002700 DXD motif; other site 663278002701 PilZ domain; Region: PilZ; pfam07238 663278002702 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 663278002703 ArsC family; Region: ArsC; pfam03960 663278002704 putative ArsC-like catalytic residues; other site 663278002705 putative TRX-like catalytic residues [active] 663278002706 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 663278002707 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 663278002708 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 663278002709 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 663278002710 ligand binding site [chemical binding]; other site 663278002711 GAF domain; Region: GAF; cl17456 663278002712 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278002713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278002714 metal binding site [ion binding]; metal-binding site 663278002715 active site 663278002716 I-site; other site 663278002717 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278002718 PAS domain S-box; Region: sensory_box; TIGR00229 663278002719 Histidine kinase; Region: His_kinase; pfam06580 663278002720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278002721 ATP binding site [chemical binding]; other site 663278002722 Mg2+ binding site [ion binding]; other site 663278002723 G-X-G motif; other site 663278002724 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 663278002725 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 663278002726 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 663278002727 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 663278002728 Catalytic site [active] 663278002729 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278002730 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278002731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278002732 Walker A/P-loop; other site 663278002733 ATP binding site [chemical binding]; other site 663278002734 Q-loop/lid; other site 663278002735 ABC transporter signature motif; other site 663278002736 Walker B; other site 663278002737 D-loop; other site 663278002738 H-loop/switch region; other site 663278002739 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 663278002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278002741 active site 663278002742 phosphorylation site [posttranslational modification] 663278002743 intermolecular recognition site; other site 663278002744 dimerization interface [polypeptide binding]; other site 663278002745 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278002746 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278002747 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278002748 transposase/IS protein; Provisional; Region: PRK09183 663278002749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278002750 Walker A motif; other site 663278002751 ATP binding site [chemical binding]; other site 663278002752 Walker B motif; other site 663278002753 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 663278002754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278002755 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278002756 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278002757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278002758 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278002759 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278002760 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278002761 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 663278002762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278002763 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278002764 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278002765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278002766 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278002767 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278002768 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278002769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 663278002770 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 663278002771 active site 663278002772 catalytic tetrad [active] 663278002773 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 663278002774 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 663278002775 active site 663278002776 substrate binding site [chemical binding]; other site 663278002777 metal binding site [ion binding]; metal-binding site 663278002778 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 663278002779 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 663278002780 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 663278002781 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 663278002782 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 663278002783 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 663278002784 beta-galactosidase; Region: BGL; TIGR03356 663278002785 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 663278002786 Melibiase; Region: Melibiase; pfam02065 663278002787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 663278002788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 663278002789 DNA binding site [nucleotide binding] 663278002790 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 663278002791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 663278002792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278002793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 663278002794 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 663278002795 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 663278002796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002797 conserved gate region; other site 663278002798 dimer interface [polypeptide binding]; other site 663278002799 putative PBP binding loops; other site 663278002800 ABC-ATPase subunit interface; other site 663278002801 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 663278002802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002803 dimer interface [polypeptide binding]; other site 663278002804 conserved gate region; other site 663278002805 ABC-ATPase subunit interface; other site 663278002806 Domain of unknown function (DUF377); Region: DUF377; pfam04041 663278002807 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 663278002808 active site 663278002809 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 663278002810 dimerization interface [polypeptide binding]; other site 663278002811 putative active cleft [active] 663278002812 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 663278002813 active site 663278002814 Domain of unknown function (DUF303); Region: DUF303; pfam03629 663278002815 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 663278002816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278002817 dimerization interface [polypeptide binding]; other site 663278002818 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 663278002819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 663278002820 dimer interface [polypeptide binding]; other site 663278002821 putative CheW interface [polypeptide binding]; other site 663278002822 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 663278002823 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 663278002824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002825 dimer interface [polypeptide binding]; other site 663278002826 conserved gate region; other site 663278002827 putative PBP binding loops; other site 663278002828 ABC-ATPase subunit interface; other site 663278002829 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 663278002830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278002831 dimer interface [polypeptide binding]; other site 663278002832 conserved gate region; other site 663278002833 putative PBP binding loops; other site 663278002834 ABC-ATPase subunit interface; other site 663278002835 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 663278002836 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 663278002837 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 663278002838 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 663278002839 Walker A/P-loop; other site 663278002840 ATP binding site [chemical binding]; other site 663278002841 Q-loop/lid; other site 663278002842 ABC transporter signature motif; other site 663278002843 Walker B; other site 663278002844 D-loop; other site 663278002845 H-loop/switch region; other site 663278002846 TOBE domain; Region: TOBE_2; pfam08402 663278002847 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 663278002848 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 663278002849 active site 663278002850 catalytic site [active] 663278002851 metal binding site [ion binding]; metal-binding site 663278002852 dimer interface [polypeptide binding]; other site 663278002853 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 663278002854 active site 663278002855 Zn binding site [ion binding]; other site 663278002856 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 663278002857 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 663278002858 dimer interface [polypeptide binding]; other site 663278002859 ADP-ribose binding site [chemical binding]; other site 663278002860 active site 663278002861 nudix motif; other site 663278002862 metal binding site [ion binding]; metal-binding site 663278002863 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 663278002864 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 663278002865 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 663278002866 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 663278002867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278002868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278002869 homodimer interface [polypeptide binding]; other site 663278002870 catalytic residue [active] 663278002871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278002872 Coenzyme A binding pocket [chemical binding]; other site 663278002873 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 663278002874 amidohydrolase; Region: amidohydrolases; TIGR01891 663278002875 metal binding site [ion binding]; metal-binding site 663278002876 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 663278002877 tartrate dehydrogenase; Region: TTC; TIGR02089 663278002878 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 663278002879 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 663278002880 substrate binding site [chemical binding]; other site 663278002881 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 663278002882 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 663278002883 substrate binding site [chemical binding]; other site 663278002884 ligand binding site [chemical binding]; other site 663278002885 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 663278002886 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 663278002887 active site 663278002888 catalytic residues [active] 663278002889 metal binding site [ion binding]; metal-binding site 663278002890 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 663278002891 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 663278002892 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 663278002893 PYR/PP interface [polypeptide binding]; other site 663278002894 dimer interface [polypeptide binding]; other site 663278002895 TPP binding site [chemical binding]; other site 663278002896 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 663278002897 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 663278002898 TPP-binding site [chemical binding]; other site 663278002899 dimer interface [polypeptide binding]; other site 663278002900 AIPR protein; Region: AIPR; pfam10592 663278002901 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 663278002902 MarR family; Region: MarR_2; pfam12802 663278002903 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 663278002904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278002905 putative substrate translocation pore; other site 663278002906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278002907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278002908 non-specific DNA binding site [nucleotide binding]; other site 663278002909 salt bridge; other site 663278002910 sequence-specific DNA binding site [nucleotide binding]; other site 663278002911 Isochorismatase family; Region: Isochorismatase; pfam00857 663278002912 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 663278002913 catalytic triad [active] 663278002914 conserved cis-peptide bond; other site 663278002915 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278002916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278002917 non-specific DNA binding site [nucleotide binding]; other site 663278002918 salt bridge; other site 663278002919 sequence-specific DNA binding site [nucleotide binding]; other site 663278002920 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278002921 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 663278002922 catalytic residues [active] 663278002923 catalytic nucleophile [active] 663278002924 Recombinase; Region: Recombinase; pfam07508 663278002925 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278002926 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 663278002927 dimer interface [polypeptide binding]; other site 663278002928 FMN binding site [chemical binding]; other site 663278002929 Predicted transcriptional regulators [Transcription]; Region: COG1733 663278002930 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 663278002931 transposase/IS protein; Provisional; Region: PRK09183 663278002932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278002933 Walker A motif; other site 663278002934 ATP binding site [chemical binding]; other site 663278002935 Walker B motif; other site 663278002936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 663278002937 Integrase core domain; Region: rve; pfam00665 663278002938 helicase superfamily c-terminal domain; Region: HELICc; smart00490 663278002939 Methyltransferase domain; Region: Methyltransf_31; pfam13847 663278002940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278002941 S-adenosylmethionine binding site [chemical binding]; other site 663278002942 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 663278002943 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 663278002944 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 663278002945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278002946 FeS/SAM binding site; other site 663278002947 Ycf46; Provisional; Region: ycf46; CHL00195 663278002948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278002949 Walker A motif; other site 663278002950 ATP binding site [chemical binding]; other site 663278002951 Walker B motif; other site 663278002952 arginine finger; other site 663278002953 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 663278002954 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 663278002955 Mrr N-terminal domain; Region: Mrr_N; pfam14338 663278002956 Restriction endonuclease; Region: Mrr_cat; pfam04471 663278002957 Part of AAA domain; Region: AAA_19; pfam13245 663278002958 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 663278002959 AAA domain; Region: AAA_12; pfam13087 663278002960 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 663278002961 transposase/IS protein; Provisional; Region: PRK09183 663278002962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278002963 Walker A motif; other site 663278002964 ATP binding site [chemical binding]; other site 663278002965 Walker B motif; other site 663278002966 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 663278002967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 663278002968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278002969 putative substrate translocation pore; other site 663278002970 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 663278002971 substrate binding site [chemical binding]; other site 663278002972 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 663278002973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278002974 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278002975 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278002976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278002977 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278002978 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278002979 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278002980 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 663278002981 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 663278002982 active site 663278002983 catalytic residues [active] 663278002984 metal binding site [ion binding]; metal-binding site 663278002985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278002986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278002987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278002988 dimerization interface [polypeptide binding]; other site 663278002989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278002990 dimerization interface [polypeptide binding]; other site 663278002991 putative DNA binding site [nucleotide binding]; other site 663278002992 putative Zn2+ binding site [ion binding]; other site 663278002993 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 663278002994 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 663278002995 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 663278002996 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 663278002997 arsenical-resistance protein; Region: acr3; TIGR00832 663278002998 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 663278002999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 663278003000 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 663278003001 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 663278003002 active site residue [active] 663278003003 Clp protease; Region: CLP_protease; pfam00574 663278003004 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 663278003005 oligomer interface [polypeptide binding]; other site 663278003006 active site residues [active] 663278003007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 663278003008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278003009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 663278003010 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 663278003011 metal-binding site [ion binding] 663278003012 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 663278003013 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278003014 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 663278003015 Walker A/P-loop; other site 663278003016 ATP binding site [chemical binding]; other site 663278003017 Q-loop/lid; other site 663278003018 ABC transporter signature motif; other site 663278003019 Walker B; other site 663278003020 D-loop; other site 663278003021 H-loop/switch region; other site 663278003022 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 663278003023 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 663278003024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 663278003025 ABC-ATPase subunit interface; other site 663278003026 dimer interface [polypeptide binding]; other site 663278003027 putative PBP binding regions; other site 663278003028 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 663278003029 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 663278003030 putative metal binding site [ion binding]; other site 663278003031 Family description; Region: DsbD_2; pfam13386 663278003032 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 663278003033 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 663278003034 metal-binding site [ion binding] 663278003035 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278003036 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 663278003037 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 663278003038 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 663278003039 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 663278003040 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 663278003041 catalytic residues [active] 663278003042 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 663278003043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 663278003044 ABC-ATPase subunit interface; other site 663278003045 dimer interface [polypeptide binding]; other site 663278003046 putative PBP binding regions; other site 663278003047 Mrr N-terminal domain; Region: Mrr_N; pfam14338 663278003048 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 663278003049 Domain of unknown function (DUF364); Region: DUF364; pfam04016 663278003050 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 663278003051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278003052 Walker A/P-loop; other site 663278003053 ATP binding site [chemical binding]; other site 663278003054 ABC transporter signature motif; other site 663278003055 Walker B; other site 663278003056 H-loop/switch region; other site 663278003057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 663278003058 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 663278003059 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 663278003060 ABC-ATPase subunit interface; other site 663278003061 dimer interface [polypeptide binding]; other site 663278003062 putative PBP binding regions; other site 663278003063 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 663278003064 Domain of unknown function (DUF364); Region: DUF364; pfam04016 663278003065 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 663278003066 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 663278003067 putative metal binding site [ion binding]; other site 663278003068 pyruvate carboxylase; Reviewed; Region: PRK12999 663278003069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 663278003070 ATP-grasp domain; Region: ATP-grasp_4; cl17255 663278003071 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 663278003072 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 663278003073 active site 663278003074 catalytic residues [active] 663278003075 metal binding site [ion binding]; metal-binding site 663278003076 homodimer binding site [polypeptide binding]; other site 663278003077 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 663278003078 carboxyltransferase (CT) interaction site; other site 663278003079 biotinylation site [posttranslational modification]; other site 663278003080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 663278003081 PAS fold; Region: PAS_3; pfam08447 663278003082 putative active site [active] 663278003083 heme pocket [chemical binding]; other site 663278003084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278003085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278003086 metal binding site [ion binding]; metal-binding site 663278003087 active site 663278003088 I-site; other site 663278003089 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278003090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278003091 metal binding site [ion binding]; metal-binding site 663278003092 active site 663278003093 I-site; other site 663278003094 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278003095 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 663278003096 Uncharacterized conserved protein [Function unknown]; Region: COG2006 663278003097 4Fe-4S binding domain; Region: Fer4; pfam00037 663278003098 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 663278003099 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 663278003100 Isochorismatase family; Region: Isochorismatase; pfam00857 663278003101 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 663278003102 catalytic triad [active] 663278003103 conserved cis-peptide bond; other site 663278003104 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 663278003105 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 663278003106 DNA binding residues [nucleotide binding] 663278003107 Isochorismatase family; Region: Isochorismatase; pfam00857 663278003108 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 663278003109 catalytic triad [active] 663278003110 conserved cis-peptide bond; other site 663278003111 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 663278003112 putative hydrophobic ligand binding site [chemical binding]; other site 663278003113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278003114 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 663278003115 Walker A motif; other site 663278003116 ATP binding site [chemical binding]; other site 663278003117 Walker B motif; other site 663278003118 arginine finger; other site 663278003119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278003120 Walker A motif; other site 663278003121 ATP binding site [chemical binding]; other site 663278003122 Walker B motif; other site 663278003123 arginine finger; other site 663278003124 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 663278003125 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 663278003126 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 663278003127 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 663278003128 dimerization interface 3.5A [polypeptide binding]; other site 663278003129 active site 663278003130 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 663278003131 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 663278003132 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 663278003133 Walker A/P-loop; other site 663278003134 ATP binding site [chemical binding]; other site 663278003135 Q-loop/lid; other site 663278003136 ABC transporter signature motif; other site 663278003137 Walker B; other site 663278003138 D-loop; other site 663278003139 H-loop/switch region; other site 663278003140 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 663278003141 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 663278003142 Walker A/P-loop; other site 663278003143 ATP binding site [chemical binding]; other site 663278003144 Q-loop/lid; other site 663278003145 ABC transporter signature motif; other site 663278003146 Walker B; other site 663278003147 D-loop; other site 663278003148 H-loop/switch region; other site 663278003149 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 663278003150 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 663278003151 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 663278003152 active site 663278003153 substrate binding site [chemical binding]; other site 663278003154 metal binding site [ion binding]; metal-binding site 663278003155 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 663278003156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278003157 Walker A motif; other site 663278003158 ATP binding site [chemical binding]; other site 663278003159 Walker B motif; other site 663278003160 arginine finger; other site 663278003161 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 663278003162 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 663278003163 RuvA N terminal domain; Region: RuvA_N; pfam01330 663278003164 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 663278003165 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 663278003166 active site 663278003167 putative DNA-binding cleft [nucleotide binding]; other site 663278003168 dimer interface [polypeptide binding]; other site 663278003169 dipeptidase PepV; Reviewed; Region: PRK07318 663278003170 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 663278003171 active site 663278003172 metal binding site [ion binding]; metal-binding site 663278003173 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 663278003174 Ligand Binding Site [chemical binding]; other site 663278003175 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 663278003176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278003177 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 663278003178 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 663278003179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278003180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278003181 active site 663278003182 phosphorylation site [posttranslational modification] 663278003183 intermolecular recognition site; other site 663278003184 dimerization interface [polypeptide binding]; other site 663278003185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278003186 DNA binding site [nucleotide binding] 663278003187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278003188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278003189 dimer interface [polypeptide binding]; other site 663278003190 phosphorylation site [posttranslational modification] 663278003191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278003192 ATP binding site [chemical binding]; other site 663278003193 Mg2+ binding site [ion binding]; other site 663278003194 G-X-G motif; other site 663278003195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278003196 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278003197 Walker A/P-loop; other site 663278003198 ATP binding site [chemical binding]; other site 663278003199 Q-loop/lid; other site 663278003200 ABC transporter signature motif; other site 663278003201 Walker B; other site 663278003202 D-loop; other site 663278003203 H-loop/switch region; other site 663278003204 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 663278003205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278003206 FtsX-like permease family; Region: FtsX; pfam02687 663278003207 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 663278003208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278003209 FtsX-like permease family; Region: FtsX; pfam02687 663278003210 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 663278003211 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 663278003212 active site 663278003213 Zn binding site [ion binding]; other site 663278003214 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 663278003215 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 663278003216 nucleotide binding pocket [chemical binding]; other site 663278003217 K-X-D-G motif; other site 663278003218 catalytic site [active] 663278003219 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 663278003220 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 663278003221 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 663278003222 Dimer interface [polypeptide binding]; other site 663278003223 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 663278003224 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 663278003225 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 663278003226 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 663278003227 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 663278003228 GatB domain; Region: GatB_Yqey; smart00845 663278003229 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 663278003230 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 663278003231 active site 663278003232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278003233 S-adenosylmethionine binding site [chemical binding]; other site 663278003234 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 663278003235 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 663278003236 Ligand binding site; other site 663278003237 Putative Catalytic site; other site 663278003238 DXD motif; other site 663278003239 GtrA-like protein; Region: GtrA; pfam04138 663278003240 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 663278003241 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 663278003242 ATP binding site [chemical binding]; other site 663278003243 Mg++ binding site [ion binding]; other site 663278003244 motif III; other site 663278003245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278003246 nucleotide binding region [chemical binding]; other site 663278003247 ATP-binding site [chemical binding]; other site 663278003248 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 663278003249 RNA binding site [nucleotide binding]; other site 663278003250 EDD domain protein, DegV family; Region: DegV; TIGR00762 663278003251 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 663278003252 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 663278003253 Cation efflux family; Region: Cation_efflux; pfam01545 663278003254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278003255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278003256 active site 663278003257 phosphorylation site [posttranslational modification] 663278003258 intermolecular recognition site; other site 663278003259 dimerization interface [polypeptide binding]; other site 663278003260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278003261 DNA binding site [nucleotide binding] 663278003262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278003263 dimerization interface [polypeptide binding]; other site 663278003264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278003265 dimer interface [polypeptide binding]; other site 663278003266 phosphorylation site [posttranslational modification] 663278003267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278003268 ATP binding site [chemical binding]; other site 663278003269 Mg2+ binding site [ion binding]; other site 663278003270 G-X-G motif; other site 663278003271 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 663278003272 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 663278003273 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 663278003274 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 663278003275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 663278003276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 663278003277 dimer interface [polypeptide binding]; other site 663278003278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278003279 catalytic residue [active] 663278003280 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 663278003281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278003282 Zn2+ binding site [ion binding]; other site 663278003283 Mg2+ binding site [ion binding]; other site 663278003284 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 663278003285 DNA primase, catalytic core; Region: dnaG; TIGR01391 663278003286 CHC2 zinc finger; Region: zf-CHC2; pfam01807 663278003287 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 663278003288 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 663278003289 active site 663278003290 metal binding site [ion binding]; metal-binding site 663278003291 interdomain interaction site; other site 663278003292 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 663278003293 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 663278003294 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 663278003295 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 663278003296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278003297 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 663278003298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278003299 DNA binding residues [nucleotide binding] 663278003300 Rrf2 family protein; Region: rrf2_super; TIGR00738 663278003301 Transcriptional regulator; Region: Rrf2; pfam02082 663278003302 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 663278003303 Rubredoxin; Region: Rubredoxin; pfam00301 663278003304 iron binding site [ion binding]; other site 663278003305 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 663278003306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 663278003307 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 663278003308 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 663278003309 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 663278003310 HSP70 interaction site [polypeptide binding]; other site 663278003311 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 663278003312 Ferritin-like domain; Region: Ferritin; pfam00210 663278003313 ferroxidase diiron center [ion binding]; other site 663278003314 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 663278003315 metal-binding site [ion binding] 663278003316 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 663278003317 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 663278003318 metal-binding site [ion binding] 663278003319 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278003320 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278003321 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 663278003322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 663278003323 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 663278003324 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 663278003325 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 663278003326 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 663278003327 RPB10 interaction site [polypeptide binding]; other site 663278003328 RPB1 interaction site [polypeptide binding]; other site 663278003329 RPB11 interaction site [polypeptide binding]; other site 663278003330 RPB3 interaction site [polypeptide binding]; other site 663278003331 RPB12 interaction site [polypeptide binding]; other site 663278003332 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 663278003333 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 663278003334 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 663278003335 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 663278003336 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 663278003337 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 663278003338 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 663278003339 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 663278003340 G-loop; other site 663278003341 DNA binding site [nucleotide binding] 663278003342 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 663278003343 S17 interaction site [polypeptide binding]; other site 663278003344 S8 interaction site; other site 663278003345 16S rRNA interaction site [nucleotide binding]; other site 663278003346 streptomycin interaction site [chemical binding]; other site 663278003347 23S rRNA interaction site [nucleotide binding]; other site 663278003348 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 663278003349 30S ribosomal protein S7; Validated; Region: PRK05302 663278003350 elongation factor G; Reviewed; Region: PRK00007 663278003351 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 663278003352 G1 box; other site 663278003353 putative GEF interaction site [polypeptide binding]; other site 663278003354 GTP/Mg2+ binding site [chemical binding]; other site 663278003355 Switch I region; other site 663278003356 G2 box; other site 663278003357 G3 box; other site 663278003358 Switch II region; other site 663278003359 G4 box; other site 663278003360 G5 box; other site 663278003361 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 663278003362 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 663278003363 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 663278003364 elongation factor Tu; Reviewed; Region: PRK00049 663278003365 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 663278003366 G1 box; other site 663278003367 GEF interaction site [polypeptide binding]; other site 663278003368 GTP/Mg2+ binding site [chemical binding]; other site 663278003369 Switch I region; other site 663278003370 G2 box; other site 663278003371 G3 box; other site 663278003372 Switch II region; other site 663278003373 G4 box; other site 663278003374 G5 box; other site 663278003375 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 663278003376 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 663278003377 Antibiotic Binding Site [chemical binding]; other site 663278003378 PemK-like protein; Region: PemK; pfam02452 663278003379 Coat F domain; Region: Coat_F; pfam07875 663278003380 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 663278003381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278003382 active site 663278003383 motif I; other site 663278003384 motif II; other site 663278003385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278003386 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 663278003387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278003388 motif II; other site 663278003389 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 663278003390 RNA polymerase factor sigma-70; Validated; Region: PRK08295 663278003391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278003392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 663278003393 DNA binding residues [nucleotide binding] 663278003394 Probable zinc-binding domain; Region: zf-trcl; pfam13451 663278003395 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 663278003396 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 663278003397 Family of unknown function (DUF633); Region: DUF633; pfam04816 663278003398 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 663278003399 Uncharacterized conserved protein [Function unknown]; Region: COG0327 663278003400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 663278003401 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 663278003402 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 663278003403 Domain of unknown function (DUF814); Region: DUF814; pfam05670 663278003404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278003405 Coenzyme A binding pocket [chemical binding]; other site 663278003406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 663278003407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278003408 Coenzyme A binding pocket [chemical binding]; other site 663278003409 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 663278003410 Peptidase family M23; Region: Peptidase_M23; pfam01551 663278003411 Uncharacterized conserved protein [Function unknown]; Region: COG2898 663278003412 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 663278003413 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 663278003414 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 663278003415 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 663278003416 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 663278003417 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 663278003418 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 663278003419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278003420 putative active site [active] 663278003421 putative metal binding site [ion binding]; other site 663278003422 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 663278003423 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 663278003424 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 663278003425 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 663278003426 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 663278003427 Dimer interface [polypeptide binding]; other site 663278003428 anticodon binding site; other site 663278003429 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 663278003430 motif 1; other site 663278003431 dimer interface [polypeptide binding]; other site 663278003432 active site 663278003433 motif 2; other site 663278003434 motif 3; other site 663278003435 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 663278003436 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 663278003437 GatB domain; Region: GatB_Yqey; smart00845 663278003438 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 663278003439 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 663278003440 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 663278003441 CheW-like domain; Region: CheW; pfam01584 663278003442 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 663278003443 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 663278003444 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 663278003445 G1 box; other site 663278003446 GTP/Mg2+ binding site [chemical binding]; other site 663278003447 Switch I region; other site 663278003448 G2 box; other site 663278003449 G3 box; other site 663278003450 Switch II region; other site 663278003451 G4 box; other site 663278003452 G5 box; other site 663278003453 Nucleoside recognition; Region: Gate; pfam07670 663278003454 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 663278003455 Nucleoside recognition; Region: Gate; pfam07670 663278003456 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 663278003457 FeoA domain; Region: FeoA; pfam04023 663278003458 Transcriptional regulator [Transcription]; Region: LytR; COG1316 663278003459 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 663278003460 Bacterial sugar transferase; Region: Bac_transf; pfam02397 663278003461 short chain dehydrogenase; Provisional; Region: PRK06701 663278003462 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 663278003463 NAD binding site [chemical binding]; other site 663278003464 metal binding site [ion binding]; metal-binding site 663278003465 active site 663278003466 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 663278003467 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 663278003468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278003469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278003470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278003471 dimerization interface [polypeptide binding]; other site 663278003472 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 663278003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278003474 S-adenosylmethionine binding site [chemical binding]; other site 663278003475 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 663278003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278003477 S-adenosylmethionine binding site [chemical binding]; other site 663278003478 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278003479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278003480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278003481 DNA binding residues [nucleotide binding] 663278003482 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 663278003483 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 663278003484 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 663278003485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278003486 dimerization interface [polypeptide binding]; other site 663278003487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278003488 dimer interface [polypeptide binding]; other site 663278003489 phosphorylation site [posttranslational modification] 663278003490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278003491 ATP binding site [chemical binding]; other site 663278003492 Mg2+ binding site [ion binding]; other site 663278003493 G-X-G motif; other site 663278003494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278003495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278003496 active site 663278003497 phosphorylation site [posttranslational modification] 663278003498 intermolecular recognition site; other site 663278003499 dimerization interface [polypeptide binding]; other site 663278003500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278003501 DNA binding site [nucleotide binding] 663278003502 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 663278003503 ABC-2 type transporter; Region: ABC2_membrane; cl17235 663278003504 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 663278003505 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278003506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278003507 Walker A/P-loop; other site 663278003508 ATP binding site [chemical binding]; other site 663278003509 Q-loop/lid; other site 663278003510 ABC transporter signature motif; other site 663278003511 Walker B; other site 663278003512 D-loop; other site 663278003513 H-loop/switch region; other site 663278003514 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 663278003515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278003516 HAMP domain; Region: HAMP; pfam00672 663278003517 dimerization interface [polypeptide binding]; other site 663278003518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278003519 dimer interface [polypeptide binding]; other site 663278003520 phosphorylation site [posttranslational modification] 663278003521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278003522 ATP binding site [chemical binding]; other site 663278003523 Mg2+ binding site [ion binding]; other site 663278003524 G-X-G motif; other site 663278003525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278003526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278003527 active site 663278003528 phosphorylation site [posttranslational modification] 663278003529 intermolecular recognition site; other site 663278003530 dimerization interface [polypeptide binding]; other site 663278003531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278003532 DNA binding site [nucleotide binding] 663278003533 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278003534 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 663278003535 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278003536 Transposase IS200 like; Region: Y1_Tnp; pfam01797 663278003537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 663278003538 Histidine kinase; Region: HisKA_3; pfam07730 663278003539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278003540 ATP binding site [chemical binding]; other site 663278003541 Mg2+ binding site [ion binding]; other site 663278003542 G-X-G motif; other site 663278003543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 663278003544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278003545 active site 663278003546 phosphorylation site [posttranslational modification] 663278003547 intermolecular recognition site; other site 663278003548 dimerization interface [polypeptide binding]; other site 663278003549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 663278003550 DNA binding residues [nucleotide binding] 663278003551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278003552 FtsX-like permease family; Region: FtsX; pfam02687 663278003553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278003554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278003555 Walker A/P-loop; other site 663278003556 ATP binding site [chemical binding]; other site 663278003557 Q-loop/lid; other site 663278003558 ABC transporter signature motif; other site 663278003559 Walker B; other site 663278003560 D-loop; other site 663278003561 H-loop/switch region; other site 663278003562 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 663278003563 FtsX-like permease family; Region: FtsX; pfam02687 663278003564 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 663278003565 Part of AAA domain; Region: AAA_19; pfam13245 663278003566 Family description; Region: UvrD_C_2; pfam13538 663278003567 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 663278003568 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 663278003569 minor groove reading motif; other site 663278003570 helix-hairpin-helix signature motif; other site 663278003571 substrate binding pocket [chemical binding]; other site 663278003572 active site 663278003573 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 663278003574 carboxyltransferase (CT) interaction site; other site 663278003575 biotinylation site [posttranslational modification]; other site 663278003576 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 663278003577 HlyD family secretion protein; Region: HlyD_3; pfam13437 663278003578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278003579 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278003580 Walker A/P-loop; other site 663278003581 ATP binding site [chemical binding]; other site 663278003582 Q-loop/lid; other site 663278003583 ABC transporter signature motif; other site 663278003584 Walker B; other site 663278003585 D-loop; other site 663278003586 H-loop/switch region; other site 663278003587 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278003588 FtsX-like permease family; Region: FtsX; pfam02687 663278003589 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 663278003590 active site 663278003591 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 663278003592 dimer interface [polypeptide binding]; other site 663278003593 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 663278003594 Ligand Binding Site [chemical binding]; other site 663278003595 Molecular Tunnel; other site 663278003596 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 663278003597 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 663278003598 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 663278003599 dimerization interface [polypeptide binding]; other site 663278003600 ATP binding site [chemical binding]; other site 663278003601 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 663278003602 dimerization interface [polypeptide binding]; other site 663278003603 ATP binding site [chemical binding]; other site 663278003604 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 663278003605 putative active site [active] 663278003606 catalytic triad [active] 663278003607 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 663278003608 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 663278003609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 663278003610 FeS/SAM binding site; other site 663278003611 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278003612 regulatory protein interface [polypeptide binding]; other site 663278003613 regulatory phosphorylation site [posttranslational modification]; other site 663278003614 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 663278003615 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 663278003616 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 663278003617 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 663278003618 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 663278003619 active site 663278003620 dimer interface [polypeptide binding]; other site 663278003621 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 663278003622 dimer interface [polypeptide binding]; other site 663278003623 active site 663278003624 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 663278003625 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 663278003626 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 663278003627 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 663278003628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 663278003629 FeS/SAM binding site; other site 663278003630 Protein of unknown function (DUF512); Region: DUF512; pfam04459 663278003631 GTP-binding protein Der; Reviewed; Region: PRK00093 663278003632 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 663278003633 G1 box; other site 663278003634 GTP/Mg2+ binding site [chemical binding]; other site 663278003635 Switch I region; other site 663278003636 G2 box; other site 663278003637 Switch II region; other site 663278003638 G3 box; other site 663278003639 G4 box; other site 663278003640 G5 box; other site 663278003641 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 663278003642 G1 box; other site 663278003643 GTP/Mg2+ binding site [chemical binding]; other site 663278003644 Switch I region; other site 663278003645 G2 box; other site 663278003646 G3 box; other site 663278003647 Switch II region; other site 663278003648 G4 box; other site 663278003649 G5 box; other site 663278003650 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 663278003651 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 663278003652 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 663278003653 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 663278003654 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 663278003655 Predicted membrane protein [Function unknown]; Region: COG2323 663278003656 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 663278003657 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 663278003658 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 663278003659 trimer interface [polypeptide binding]; other site 663278003660 active site 663278003661 substrate binding site [chemical binding]; other site 663278003662 CoA binding site [chemical binding]; other site 663278003663 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 663278003664 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 663278003665 active site 663278003666 NAD binding site [chemical binding]; other site 663278003667 metal binding site [ion binding]; metal-binding site 663278003668 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 663278003669 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 663278003670 Walker A/P-loop; other site 663278003671 ATP binding site [chemical binding]; other site 663278003672 Q-loop/lid; other site 663278003673 ABC transporter signature motif; other site 663278003674 Walker B; other site 663278003675 D-loop; other site 663278003676 H-loop/switch region; other site 663278003677 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 663278003678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278003679 dimer interface [polypeptide binding]; other site 663278003680 conserved gate region; other site 663278003681 putative PBP binding loops; other site 663278003682 ABC-ATPase subunit interface; other site 663278003683 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 663278003684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278003685 dimer interface [polypeptide binding]; other site 663278003686 conserved gate region; other site 663278003687 ABC-ATPase subunit interface; other site 663278003688 NMT1/THI5 like; Region: NMT1; pfam09084 663278003689 ATP phosphoribosyltransferase; Region: HisG; cl15266 663278003690 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 663278003691 Uncharacterized conserved protein [Function unknown]; Region: COG1683 663278003692 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 663278003693 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 663278003694 phenylhydantoinase; Validated; Region: PRK08323 663278003695 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 663278003696 tetramer interface [polypeptide binding]; other site 663278003697 active site 663278003698 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 663278003699 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 663278003700 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 663278003701 homodimer interface [polypeptide binding]; other site 663278003702 active site 663278003703 FMN binding site [chemical binding]; other site 663278003704 substrate binding site [chemical binding]; other site 663278003705 4Fe-4S binding domain; Region: Fer4; cl02805 663278003706 4Fe-4S binding domain; Region: Fer4; pfam00037 663278003707 hypothetical protein; Provisional; Region: PRK06062 663278003708 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 663278003709 inhibitor-cofactor binding pocket; inhibition site 663278003710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278003711 catalytic residue [active] 663278003712 allantoate amidohydrolase; Reviewed; Region: PRK09290 663278003713 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 663278003714 active site 663278003715 metal binding site [ion binding]; metal-binding site 663278003716 dimer interface [polypeptide binding]; other site 663278003717 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 663278003718 DNA binding site [nucleotide binding] 663278003719 Bacterial transcriptional activator domain; Region: BTAD; smart01043 663278003720 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 663278003721 metal binding site [ion binding]; metal-binding site 663278003722 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 663278003723 Uncharacterized conserved protein [Function unknown]; Region: COG3595 663278003724 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 663278003725 Predicted transcriptional regulators [Transcription]; Region: COG1695 663278003726 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 663278003727 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 663278003728 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 663278003729 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 663278003730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278003731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278003732 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 663278003733 putative dimerization interface [polypeptide binding]; other site 663278003734 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 663278003735 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 663278003736 Nucleoside recognition; Region: Gate; pfam07670 663278003737 YabP family; Region: YabP; pfam07873 663278003738 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 663278003739 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 663278003740 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 663278003741 PhoH-like protein; Region: PhoH; pfam02562 663278003742 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 663278003743 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 663278003744 GTPase Era; Reviewed; Region: era; PRK00089 663278003745 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 663278003746 G1 box; other site 663278003747 GTP/Mg2+ binding site [chemical binding]; other site 663278003748 Switch I region; other site 663278003749 G2 box; other site 663278003750 Switch II region; other site 663278003751 G3 box; other site 663278003752 G4 box; other site 663278003753 G5 box; other site 663278003754 KH domain; Region: KH_2; pfam07650 663278003755 YqzL-like protein; Region: YqzL; pfam14006 663278003756 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 663278003757 Recombination protein O N terminal; Region: RecO_N; pfam11967 663278003758 Recombination protein O C terminal; Region: RecO_C; pfam02565 663278003759 C1q domain; Region: C1q; cl17543 663278003760 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 663278003761 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 663278003762 B12 binding site [chemical binding]; other site 663278003763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278003764 FeS/SAM binding site; other site 663278003765 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 663278003766 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 663278003767 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 663278003768 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278003769 active site 663278003770 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 663278003771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278003772 Walker A motif; other site 663278003773 ATP binding site [chemical binding]; other site 663278003774 Walker B motif; other site 663278003775 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 663278003776 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 663278003777 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 663278003778 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 663278003779 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 663278003780 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562 663278003781 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 663278003782 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 663278003783 Asp23 family; Region: Asp23; pfam03780 663278003784 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 663278003785 putative RNA binding site [nucleotide binding]; other site 663278003786 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 663278003787 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 663278003788 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 663278003789 generic binding surface II; other site 663278003790 generic binding surface I; other site 663278003791 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 663278003792 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 663278003793 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 663278003794 substrate binding pocket [chemical binding]; other site 663278003795 chain length determination region; other site 663278003796 substrate-Mg2+ binding site; other site 663278003797 catalytic residues [active] 663278003798 aspartate-rich region 1; other site 663278003799 active site lid residues [active] 663278003800 aspartate-rich region 2; other site 663278003801 Divergent PAP2 family; Region: DUF212; pfam02681 663278003802 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 663278003803 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 663278003804 TPP-binding site; other site 663278003805 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 663278003806 PYR/PP interface [polypeptide binding]; other site 663278003807 dimer interface [polypeptide binding]; other site 663278003808 TPP binding site [chemical binding]; other site 663278003809 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 663278003810 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 663278003811 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278003812 RNA binding surface [nucleotide binding]; other site 663278003813 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 663278003814 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 663278003815 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 663278003816 arginine repressor; Provisional; Region: argR; PRK00441 663278003817 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 663278003818 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 663278003819 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 663278003820 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 663278003821 Walker A/P-loop; other site 663278003822 ATP binding site [chemical binding]; other site 663278003823 Q-loop/lid; other site 663278003824 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 663278003825 ABC transporter signature motif; other site 663278003826 Walker B; other site 663278003827 D-loop; other site 663278003828 H-loop/switch region; other site 663278003829 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 663278003830 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 663278003831 active site 663278003832 HIGH motif; other site 663278003833 dimer interface [polypeptide binding]; other site 663278003834 KMSKS motif; other site 663278003835 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278003836 RNA binding surface [nucleotide binding]; other site 663278003837 Protein of unknown function (DUF419); Region: DUF419; pfam04237 663278003838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278003839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278003840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 663278003841 dimerization interface [polypeptide binding]; other site 663278003842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 663278003843 classical (c) SDRs; Region: SDR_c; cd05233 663278003844 NAD(P) binding site [chemical binding]; other site 663278003845 active site 663278003846 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 663278003847 active site 663278003848 Zn binding site [ion binding]; other site 663278003849 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 663278003850 active site 663278003851 Zn binding site [ion binding]; other site 663278003852 RteC protein; Region: RteC; pfam09357 663278003853 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278003854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278003855 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278003856 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278003857 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278003858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278003859 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278003860 transposase/IS protein; Provisional; Region: PRK09183 663278003861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278003862 Walker A motif; other site 663278003863 ATP binding site [chemical binding]; other site 663278003864 Walker B motif; other site 663278003865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 663278003866 Integrase core domain; Region: rve; pfam00665 663278003867 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 663278003868 additional DNA contacts [nucleotide binding]; other site 663278003869 mismatch recognition site; other site 663278003870 active site 663278003871 zinc binding site [ion binding]; other site 663278003872 DNA intercalation site [nucleotide binding]; other site 663278003873 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 663278003874 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 663278003875 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 663278003876 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 663278003877 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 663278003878 cofactor binding site; other site 663278003879 DNA binding site [nucleotide binding] 663278003880 substrate interaction site [chemical binding]; other site 663278003881 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 663278003882 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 663278003883 cofactor binding site; other site 663278003884 DNA binding site [nucleotide binding] 663278003885 substrate interaction site [chemical binding]; other site 663278003886 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 663278003887 Helix-turn-helix domain; Region: HTH_17; pfam12728 663278003888 Transposase IS200 like; Region: Y1_Tnp; pfam01797 663278003889 AAA domain; Region: AAA_21; pfam13304 663278003890 Helix-turn-helix domain; Region: HTH_36; pfam13730 663278003891 Helix-turn-helix domain; Region: HTH_38; pfam13936 663278003892 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 663278003893 hypothetical protein; Reviewed; Region: PRK09588 663278003894 HEAT repeats; Region: HEAT_2; pfam13646 663278003895 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 663278003896 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 663278003897 WYL domain; Region: WYL; pfam13280 663278003898 WYL domain; Region: WYL; pfam13280 663278003899 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 663278003900 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 663278003901 TIGR02680 family protein; Region: TIGR02680 663278003902 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 663278003903 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 663278003904 TIGR02677 family protein; Region: TIGR02677 663278003905 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 663278003906 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 663278003907 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 663278003908 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 663278003909 ATP-binding site [chemical binding]; other site 663278003910 Transposase IS200 like; Region: Y1_Tnp; pfam01797 663278003911 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 663278003912 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 663278003913 nucleotide binding site [chemical binding]; other site 663278003914 putative NEF/HSP70 interaction site [polypeptide binding]; other site 663278003915 SBD interface [polypeptide binding]; other site 663278003916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278003917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278003918 non-specific DNA binding site [nucleotide binding]; other site 663278003919 salt bridge; other site 663278003920 sequence-specific DNA binding site [nucleotide binding]; other site 663278003921 AAA domain; Region: AAA_25; pfam13481 663278003922 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278003923 Walker A motif; other site 663278003924 ATP binding site [chemical binding]; other site 663278003925 Walker B motif; other site 663278003926 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278003927 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278003928 active site 663278003929 metal binding site [ion binding]; metal-binding site 663278003930 Predicted ATPase [General function prediction only]; Region: COG3910 663278003931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278003932 Walker A/P-loop; other site 663278003933 ATP binding site [chemical binding]; other site 663278003934 Q-loop/lid; other site 663278003935 ABC transporter signature motif; other site 663278003936 Walker B; other site 663278003937 D-loop; other site 663278003938 H-loop/switch region; other site 663278003939 Protein of unknown function (DUF419); Region: DUF419; pfam04237 663278003940 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 663278003941 ArsC family; Region: ArsC; pfam03960 663278003942 putative ArsC-like catalytic residues; other site 663278003943 putative TRX-like catalytic residues [active] 663278003944 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 663278003945 Pathogenicity locus; Region: Cdd1; pfam11731 663278003946 TfoX C-terminal domain; Region: TfoX_C; pfam04994 663278003947 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 663278003948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 663278003949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 663278003950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 663278003951 Walker A/P-loop; other site 663278003952 ATP binding site [chemical binding]; other site 663278003953 Q-loop/lid; other site 663278003954 ABC transporter signature motif; other site 663278003955 Walker B; other site 663278003956 D-loop; other site 663278003957 H-loop/switch region; other site 663278003958 Cobalt transport protein; Region: CbiQ; cl00463 663278003959 cobalt transport protein CbiM; Provisional; Region: PRK11909 663278003960 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 663278003961 AIR carboxylase; Region: AIRC; smart01001 663278003962 flavodoxin; Provisional; Region: PRK06242 663278003963 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 663278003964 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 663278003965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278003966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278003967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278003968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278003969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278003970 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 663278003971 Walker A/P-loop; other site 663278003972 ATP binding site [chemical binding]; other site 663278003973 Q-loop/lid; other site 663278003974 ABC transporter signature motif; other site 663278003975 Walker B; other site 663278003976 D-loop; other site 663278003977 H-loop/switch region; other site 663278003978 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 663278003979 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 663278003980 MOSC domain; Region: MOSC; pfam03473 663278003981 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 663278003982 trimer interface [polypeptide binding]; other site 663278003983 dimer interface [polypeptide binding]; other site 663278003984 putative active site [active] 663278003985 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 663278003986 active site 663278003987 catalytic site [active] 663278003988 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 663278003989 ABC1 family; Region: ABC1; pfam03109 663278003990 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 663278003991 active site 663278003992 ATP binding site [chemical binding]; other site 663278003993 Uncharacterized conserved protein [Function unknown]; Region: COG3937 663278003994 GAF domain; Region: GAF; pfam01590 663278003995 GAF domain; Region: GAF_2; pfam13185 663278003996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 663278003997 Zn2+ binding site [ion binding]; other site 663278003998 Mg2+ binding site [ion binding]; other site 663278003999 germination protein YpeB; Region: spore_YpeB; TIGR02889 663278004000 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 663278004001 catalytic residue [active] 663278004002 FOG: CBS domain [General function prediction only]; Region: COG0517 663278004003 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 663278004004 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 663278004005 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 663278004006 catalytic residues [active] 663278004007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 663278004008 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 663278004009 Mechanosensitive ion channel; Region: MS_channel; pfam00924 663278004010 anthranilate synthase component I; Provisional; Region: PRK13565 663278004011 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 663278004012 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 663278004013 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 663278004014 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 663278004015 glutamine binding [chemical binding]; other site 663278004016 catalytic triad [active] 663278004017 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 663278004018 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 663278004019 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 663278004020 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 663278004021 active site 663278004022 ribulose/triose binding site [chemical binding]; other site 663278004023 phosphate binding site [ion binding]; other site 663278004024 substrate (anthranilate) binding pocket [chemical binding]; other site 663278004025 product (indole) binding pocket [chemical binding]; other site 663278004026 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 663278004027 active site 663278004028 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 663278004029 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 663278004030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278004031 catalytic residue [active] 663278004032 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 663278004033 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 663278004034 substrate binding site [chemical binding]; other site 663278004035 active site 663278004036 catalytic residues [active] 663278004037 heterodimer interface [polypeptide binding]; other site 663278004038 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 663278004039 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 663278004040 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 663278004041 protein binding site [polypeptide binding]; other site 663278004042 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 663278004043 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 663278004044 catalytic residues [active] 663278004045 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 663278004046 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 663278004047 ligand binding site [chemical binding]; other site 663278004048 flexible hinge region; other site 663278004049 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 663278004050 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 663278004051 substrate binding site; other site 663278004052 dimer interface; other site 663278004053 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 663278004054 homotrimer interaction site [polypeptide binding]; other site 663278004055 zinc binding site [ion binding]; other site 663278004056 CDP-binding sites; other site 663278004057 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 663278004058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 663278004059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278004060 catalytic residue [active] 663278004061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 663278004062 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 663278004063 acyl-activating enzyme (AAE) consensus motif; other site 663278004064 AMP binding site [chemical binding]; other site 663278004065 active site 663278004066 CoA binding site [chemical binding]; other site 663278004067 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 663278004068 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 663278004069 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 663278004070 MgtE intracellular N domain; Region: MgtE_N; pfam03448 663278004071 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 663278004072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 663278004073 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 663278004074 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 663278004075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278004076 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 663278004077 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278004078 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 663278004079 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 663278004080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278004081 Walker A/P-loop; other site 663278004082 ATP binding site [chemical binding]; other site 663278004083 Q-loop/lid; other site 663278004084 ABC transporter signature motif; other site 663278004085 Walker B; other site 663278004086 D-loop; other site 663278004087 H-loop/switch region; other site 663278004088 ABC transporter; Region: ABC_tran_2; pfam12848 663278004089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 663278004090 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 663278004091 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 663278004092 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 663278004093 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 663278004094 Hpr binding site; other site 663278004095 active site 663278004096 homohexamer subunit interaction site [polypeptide binding]; other site 663278004097 putative hydrolase; Validated; Region: PRK09248 663278004098 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 663278004099 active site 663278004100 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 663278004101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 663278004102 nucleotide binding site [chemical binding]; other site 663278004103 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 663278004104 FAD binding domain; Region: FAD_binding_4; pfam01565 663278004105 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 663278004106 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 663278004107 shikimate kinase; Provisional; Region: PRK13947 663278004108 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 663278004109 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 663278004110 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 663278004111 active site 663278004112 PHP Thumb interface [polypeptide binding]; other site 663278004113 metal binding site [ion binding]; metal-binding site 663278004114 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 663278004115 generic binding surface I; other site 663278004116 generic binding surface II; other site 663278004117 6-phosphofructokinase; Provisional; Region: PRK03202 663278004118 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 663278004119 active site 663278004120 ADP/pyrophosphate binding site [chemical binding]; other site 663278004121 dimerization interface [polypeptide binding]; other site 663278004122 allosteric effector site; other site 663278004123 fructose-1,6-bisphosphate binding site; other site 663278004124 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 663278004125 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 663278004126 FAD binding pocket [chemical binding]; other site 663278004127 FAD binding motif [chemical binding]; other site 663278004128 phosphate binding motif [ion binding]; other site 663278004129 beta-alpha-beta structure motif; other site 663278004130 NAD binding pocket [chemical binding]; other site 663278004131 Iron coordination center [ion binding]; other site 663278004132 putative oxidoreductase; Provisional; Region: PRK12831 663278004133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 663278004134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 663278004135 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 663278004136 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 663278004137 NAD(P) binding site [chemical binding]; other site 663278004138 LDH/MDH dimer interface [polypeptide binding]; other site 663278004139 substrate binding site [chemical binding]; other site 663278004140 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 663278004141 active site 663278004142 metal binding site [ion binding]; metal-binding site 663278004143 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 663278004144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 663278004145 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 663278004146 active site 663278004147 DNA binding site [nucleotide binding] 663278004148 Int/Topo IB signature motif; other site 663278004149 Helix-turn-helix domain; Region: HTH_17; pfam12728 663278004150 transposase/IS protein; Provisional; Region: PRK09183 663278004151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278004152 Walker A motif; other site 663278004153 ATP binding site [chemical binding]; other site 663278004154 Walker B motif; other site 663278004155 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 663278004156 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 663278004157 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278004158 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 663278004159 Walker A/P-loop; other site 663278004160 ATP binding site [chemical binding]; other site 663278004161 Q-loop/lid; other site 663278004162 ABC transporter signature motif; other site 663278004163 Walker B; other site 663278004164 D-loop; other site 663278004165 H-loop/switch region; other site 663278004166 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 663278004167 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 663278004168 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278004169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278004170 non-specific DNA binding site [nucleotide binding]; other site 663278004171 salt bridge; other site 663278004172 sequence-specific DNA binding site [nucleotide binding]; other site 663278004173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278004174 H+ Antiporter protein; Region: 2A0121; TIGR00900 663278004175 putative substrate translocation pore; other site 663278004176 Repair protein; Region: Repair_PSII; pfam04536 663278004177 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 663278004178 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 663278004179 TrkA-N domain; Region: TrkA_N; pfam02254 663278004180 TrkA-C domain; Region: TrkA_C; pfam02080 663278004181 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 663278004182 TrkA-N domain; Region: TrkA_N; pfam02254 663278004183 TrkA-C domain; Region: TrkA_C; pfam02080 663278004184 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 663278004185 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 663278004186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278004187 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 663278004188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278004189 motif II; other site 663278004190 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 663278004191 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 663278004192 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 663278004193 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 663278004194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 663278004195 Coenzyme A binding pocket [chemical binding]; other site 663278004196 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 663278004197 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278004198 active site 663278004199 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 663278004200 NodB motif; other site 663278004201 active site 663278004202 catalytic site [active] 663278004203 metal binding site [ion binding]; metal-binding site 663278004204 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 663278004205 FAD binding site [chemical binding]; other site 663278004206 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 663278004207 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 663278004208 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 663278004209 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 663278004210 substrate binding pocket [chemical binding]; other site 663278004211 dihydropteroate synthase; Region: DHPS; TIGR01496 663278004212 dimer interface [polypeptide binding]; other site 663278004213 inhibitor binding site; inhibition site 663278004214 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 663278004215 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 663278004216 B12 binding site [chemical binding]; other site 663278004217 biotin synthase; Region: bioB; TIGR00433 663278004218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278004219 FeS/SAM binding site; other site 663278004220 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 663278004221 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 663278004222 Biotin operon repressor [Transcription]; Region: BirA; COG1654 663278004223 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 663278004224 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 663278004225 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 663278004226 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 663278004227 catalytic core [active] 663278004228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 663278004229 Heavy-metal-associated domain; Region: HMA; pfam00403 663278004230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 663278004231 catalytic residues [active] 663278004232 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 663278004233 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 663278004234 putative catalytic cysteine [active] 663278004235 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 663278004236 putative active site [active] 663278004237 metal binding site [ion binding]; metal-binding site 663278004238 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 663278004239 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 663278004240 CoA binding domain; Region: CoA_binding; pfam02629 663278004241 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 663278004242 aconitate hydratase; Validated; Region: PRK07229 663278004243 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 663278004244 substrate binding site [chemical binding]; other site 663278004245 ligand binding site [chemical binding]; other site 663278004246 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 663278004247 substrate binding site [chemical binding]; other site 663278004248 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 663278004249 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 663278004250 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 663278004251 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 663278004252 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 663278004253 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 663278004254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 663278004255 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 663278004256 active site 663278004257 YlzJ-like protein; Region: YlzJ; pfam14035 663278004258 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 663278004259 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 663278004260 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 663278004261 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 663278004262 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 663278004263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 663278004264 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 663278004265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 663278004266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 663278004267 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278004268 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278004269 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 663278004270 Walker A/P-loop; other site 663278004271 ATP binding site [chemical binding]; other site 663278004272 Q-loop/lid; other site 663278004273 ABC transporter signature motif; other site 663278004274 Walker B; other site 663278004275 D-loop; other site 663278004276 H-loop/switch region; other site 663278004277 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 663278004278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 663278004279 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 663278004280 putative deacylase active site [active] 663278004281 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 663278004282 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 663278004283 Peptidase family M23; Region: Peptidase_M23; pfam01551 663278004284 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 663278004285 Peptidase family M50; Region: Peptidase_M50; pfam02163 663278004286 active site 663278004287 putative substrate binding region [chemical binding]; other site 663278004288 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 663278004289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278004290 Coenzyme A binding pocket [chemical binding]; other site 663278004291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278004292 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 663278004293 FtsX-like permease family; Region: FtsX; pfam02687 663278004294 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 663278004295 HlyD family secretion protein; Region: HlyD_3; pfam13437 663278004296 DNA repair protein RadA; Provisional; Region: PRK11823 663278004297 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278004298 Walker A motif; other site 663278004299 ATP binding site [chemical binding]; other site 663278004300 Walker B motif; other site 663278004301 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 663278004302 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 663278004303 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 663278004304 active site 663278004305 metal binding site [ion binding]; metal-binding site 663278004306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 663278004307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 663278004308 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 663278004309 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 663278004310 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 663278004311 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 663278004312 DNA binding site [nucleotide binding] 663278004313 active site 663278004314 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 663278004315 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 663278004316 active site 663278004317 DNA binding site [nucleotide binding] 663278004318 Int/Topo IB signature motif; other site 663278004319 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 663278004320 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 663278004321 active site 663278004322 Int/Topo IB signature motif; other site 663278004323 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 663278004324 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 663278004325 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 663278004326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278004327 FeS/SAM binding site; other site 663278004328 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 663278004329 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 663278004330 Preprotein translocase subunit; Region: YajC; pfam02699 663278004331 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 663278004332 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 663278004333 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 663278004334 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 663278004335 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 663278004336 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 663278004337 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 663278004338 dihydrodipicolinate synthase; Region: dapA; TIGR00674 663278004339 dimer interface [polypeptide binding]; other site 663278004340 active site 663278004341 catalytic residue [active] 663278004342 dihydrodipicolinate reductase; Provisional; Region: PRK00048 663278004343 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 663278004344 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 663278004345 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 663278004346 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 663278004347 stage V sporulation protein B; Region: spore_V_B; TIGR02900 663278004348 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 663278004349 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 663278004350 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 663278004351 Flavoprotein; Region: Flavoprotein; pfam02441 663278004352 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 663278004353 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 663278004354 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 663278004355 metal binding site [ion binding]; metal-binding site 663278004356 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 663278004357 metal binding site [ion binding]; metal-binding site 663278004358 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 663278004359 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 663278004360 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 663278004361 substrate binding site [chemical binding]; other site 663278004362 glutamase interaction surface [polypeptide binding]; other site 663278004363 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 663278004364 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 663278004365 catalytic residues [active] 663278004366 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 663278004367 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 663278004368 putative active site [active] 663278004369 oxyanion strand; other site 663278004370 catalytic triad [active] 663278004371 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 663278004372 putative active site pocket [active] 663278004373 4-fold oligomerization interface [polypeptide binding]; other site 663278004374 metal binding residues [ion binding]; metal-binding site 663278004375 3-fold/trimer interface [polypeptide binding]; other site 663278004376 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 663278004377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278004378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278004379 homodimer interface [polypeptide binding]; other site 663278004380 catalytic residue [active] 663278004381 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 663278004382 histidinol dehydrogenase; Region: hisD; TIGR00069 663278004383 NAD binding site [chemical binding]; other site 663278004384 dimerization interface [polypeptide binding]; other site 663278004385 product binding site; other site 663278004386 substrate binding site [chemical binding]; other site 663278004387 zinc binding site [ion binding]; other site 663278004388 catalytic residues [active] 663278004389 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 663278004390 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 663278004391 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 663278004392 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 663278004393 dimer interface [polypeptide binding]; other site 663278004394 motif 1; other site 663278004395 active site 663278004396 motif 2; other site 663278004397 motif 3; other site 663278004398 LabA_like proteins; Region: LabA_like; cd06167 663278004399 putative metal binding site [ion binding]; other site 663278004400 Uncharacterized conserved protein [Function unknown]; Region: COG1432 663278004401 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 663278004402 methionine sulfoxide reductase B; Provisional; Region: PRK00222 663278004403 SelR domain; Region: SelR; pfam01641 663278004404 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 663278004405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278004406 S-adenosylmethionine binding site [chemical binding]; other site 663278004407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 663278004408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278004409 active site 663278004410 phosphorylation site [posttranslational modification] 663278004411 intermolecular recognition site; other site 663278004412 dimerization interface [polypeptide binding]; other site 663278004413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 663278004414 DNA binding residues [nucleotide binding] 663278004415 dimerization interface [polypeptide binding]; other site 663278004416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 663278004417 Histidine kinase; Region: HisKA_3; pfam07730 663278004418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278004419 ATP binding site [chemical binding]; other site 663278004420 Mg2+ binding site [ion binding]; other site 663278004421 G-X-G motif; other site 663278004422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278004423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278004424 Walker A/P-loop; other site 663278004425 ATP binding site [chemical binding]; other site 663278004426 Q-loop/lid; other site 663278004427 ABC transporter signature motif; other site 663278004428 Walker B; other site 663278004429 D-loop; other site 663278004430 H-loop/switch region; other site 663278004431 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 663278004432 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 663278004433 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 663278004434 ABC-2 type transporter; Region: ABC2_membrane; cl17235 663278004435 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 663278004436 classical (c) SDRs; Region: SDR_c; cd05233 663278004437 NAD(P) binding site [chemical binding]; other site 663278004438 active site 663278004439 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 663278004440 beta-galactosidase; Region: BGL; TIGR03356 663278004441 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 663278004442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 663278004443 dimer interface [polypeptide binding]; other site 663278004444 putative CheW interface [polypeptide binding]; other site 663278004445 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 663278004446 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 663278004447 minor groove reading motif; other site 663278004448 helix-hairpin-helix signature motif; other site 663278004449 substrate binding pocket [chemical binding]; other site 663278004450 active site 663278004451 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 663278004452 DNA binding and oxoG recognition site [nucleotide binding] 663278004453 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 663278004454 Family description; Region: UvrD_C_2; pfam13538 663278004455 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 663278004456 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 663278004457 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 663278004458 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 663278004459 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 663278004460 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 663278004461 RNA binding site [nucleotide binding]; other site 663278004462 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 663278004463 RNA binding site [nucleotide binding]; other site 663278004464 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 663278004465 RNA binding site [nucleotide binding]; other site 663278004466 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 663278004467 RNA binding site [nucleotide binding]; other site 663278004468 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 663278004469 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 663278004470 putative acyl-acceptor binding pocket; other site 663278004471 cytidylate kinase; Provisional; Region: cmk; PRK00023 663278004472 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 663278004473 CMP-binding site; other site 663278004474 The sites determining sugar specificity; other site 663278004475 HI0933-like protein; Region: HI0933_like; pfam03486 663278004476 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 663278004477 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 663278004478 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 663278004479 putative active site [active] 663278004480 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 663278004481 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 663278004482 active site 663278004483 metal binding site [ion binding]; metal-binding site 663278004484 homotetramer interface [polypeptide binding]; other site 663278004485 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 663278004486 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 663278004487 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 663278004488 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 663278004489 active site 663278004490 multimer interface [polypeptide binding]; other site 663278004491 YceG-like family; Region: YceG; pfam02618 663278004492 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 663278004493 dimerization interface [polypeptide binding]; other site 663278004494 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 663278004495 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 663278004496 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 663278004497 conserved cys residue [active] 663278004498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 663278004499 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 663278004500 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 663278004501 active site 663278004502 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 663278004503 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 663278004504 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 663278004505 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 663278004506 S-ribosylhomocysteinase; Provisional; Region: PRK02260 663278004507 Smr domain; Region: Smr; pfam01713 663278004508 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 663278004509 shikimate kinase II; Reviewed; Region: aroL; cl17327 663278004510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278004511 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 663278004512 active site 663278004513 motif I; other site 663278004514 motif II; other site 663278004515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278004516 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 663278004517 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 663278004518 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 663278004519 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 663278004520 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278004521 dimerization domain swap beta strand [polypeptide binding]; other site 663278004522 regulatory protein interface [polypeptide binding]; other site 663278004523 active site 663278004524 regulatory phosphorylation site [posttranslational modification]; other site 663278004525 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 663278004526 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 663278004527 putative substrate binding site [chemical binding]; other site 663278004528 putative ATP binding site [chemical binding]; other site 663278004529 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 663278004530 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 663278004531 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 663278004532 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 663278004533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 663278004534 active site 663278004535 HIGH motif; other site 663278004536 nucleotide binding site [chemical binding]; other site 663278004537 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 663278004538 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 663278004539 active site 663278004540 KMSKS motif; other site 663278004541 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 663278004542 tRNA binding surface [nucleotide binding]; other site 663278004543 anticodon binding site; other site 663278004544 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 663278004545 Hemerythrin; Region: Hemerythrin; cd12107 663278004546 Fe binding site [ion binding]; other site 663278004547 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 663278004548 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 663278004549 anti sigma factor interaction site; other site 663278004550 regulatory phosphorylation site [posttranslational modification]; other site 663278004551 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 663278004552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278004553 ATP binding site [chemical binding]; other site 663278004554 Mg2+ binding site [ion binding]; other site 663278004555 G-X-G motif; other site 663278004556 sporulation sigma factor SigF; Validated; Region: PRK05572 663278004557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278004558 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 663278004559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278004560 DNA binding residues [nucleotide binding] 663278004561 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 663278004562 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 663278004563 active site 663278004564 metal binding site [ion binding]; metal-binding site 663278004565 DNA binding site [nucleotide binding] 663278004566 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 663278004567 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 663278004568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278004569 Walker A/P-loop; other site 663278004570 ATP binding site [chemical binding]; other site 663278004571 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 663278004572 ABC transporter signature motif; other site 663278004573 Walker B; other site 663278004574 D-loop; other site 663278004575 H-loop/switch region; other site 663278004576 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 663278004577 ThiS interaction site; other site 663278004578 putative active site [active] 663278004579 tetramer interface [polypeptide binding]; other site 663278004580 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 663278004581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278004582 FeS/SAM binding site; other site 663278004583 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 663278004584 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 663278004585 thiamine phosphate binding site [chemical binding]; other site 663278004586 active site 663278004587 pyrophosphate binding site [ion binding]; other site 663278004588 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 663278004589 thiS-thiF/thiG interaction site; other site 663278004590 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 663278004591 active site 663278004592 metal binding site [ion binding]; metal-binding site 663278004593 Predicted transcriptional regulators [Transcription]; Region: COG1733 663278004594 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 663278004595 Isochorismatase family; Region: Isochorismatase; pfam00857 663278004596 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 663278004597 catalytic triad [active] 663278004598 conserved cis-peptide bond; other site 663278004599 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 663278004600 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 663278004601 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 663278004602 flavodoxin; Provisional; Region: PRK06242 663278004603 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 663278004604 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 663278004605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278004606 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 663278004607 EamA-like transporter family; Region: EamA; pfam00892 663278004608 EamA-like transporter family; Region: EamA; pfam00892 663278004609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278004610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278004611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278004612 dimerization interface [polypeptide binding]; other site 663278004613 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 663278004614 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 663278004615 DNA binding residues [nucleotide binding] 663278004616 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 663278004617 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 663278004618 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 663278004619 DNA binding residues [nucleotide binding] 663278004620 putative dimer interface [polypeptide binding]; other site 663278004621 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 663278004622 WHG domain; Region: WHG; pfam13305 663278004623 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 663278004624 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 663278004625 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 663278004626 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 663278004627 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 663278004628 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 663278004629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 663278004630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278004631 Coenzyme A binding pocket [chemical binding]; other site 663278004632 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 663278004633 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 663278004634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278004635 S-adenosylmethionine binding site [chemical binding]; other site 663278004636 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 663278004637 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 663278004638 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 663278004639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278004640 S-adenosylmethionine binding site [chemical binding]; other site 663278004641 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 663278004642 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 663278004643 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 663278004644 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 663278004645 excinuclease ABC subunit B; Provisional; Region: PRK05298 663278004646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278004647 ATP binding site [chemical binding]; other site 663278004648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278004649 nucleotide binding region [chemical binding]; other site 663278004650 ATP-binding site [chemical binding]; other site 663278004651 Ultra-violet resistance protein B; Region: UvrB; pfam12344 663278004652 UvrB/uvrC motif; Region: UVR; pfam02151 663278004653 hypothetical protein; Reviewed; Region: PRK00024 663278004654 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 663278004655 MPN+ (JAMM) motif; other site 663278004656 Zinc-binding site [ion binding]; other site 663278004657 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 663278004658 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 663278004659 active site 663278004660 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 663278004661 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 663278004662 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 663278004663 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 663278004664 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 663278004665 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 663278004666 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 663278004667 putative RNA binding site [nucleotide binding]; other site 663278004668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278004669 S-adenosylmethionine binding site [chemical binding]; other site 663278004670 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 663278004671 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 663278004672 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 663278004673 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278004674 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278004675 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 663278004676 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 663278004677 Probable Catalytic site; other site 663278004678 metal-binding site 663278004679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278004680 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278004681 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278004682 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 663278004683 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 663278004684 Probable Catalytic site; other site 663278004685 metal-binding site 663278004686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278004687 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278004688 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 663278004689 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 663278004690 Walker A/P-loop; other site 663278004691 ATP binding site [chemical binding]; other site 663278004692 Q-loop/lid; other site 663278004693 ABC transporter signature motif; other site 663278004694 Walker B; other site 663278004695 D-loop; other site 663278004696 H-loop/switch region; other site 663278004697 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 663278004698 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 663278004699 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 663278004700 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 663278004701 NAD binding site [chemical binding]; other site 663278004702 substrate binding site [chemical binding]; other site 663278004703 homodimer interface [polypeptide binding]; other site 663278004704 active site 663278004705 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 663278004706 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 663278004707 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 663278004708 NADP binding site [chemical binding]; other site 663278004709 active site 663278004710 putative substrate binding site [chemical binding]; other site 663278004711 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 663278004712 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278004713 active site 663278004714 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 663278004715 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 663278004716 substrate binding site; other site 663278004717 tetramer interface; other site 663278004718 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 663278004719 Ligand binding site; other site 663278004720 Putative Catalytic site; other site 663278004721 DXD motif; other site 663278004722 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 663278004723 active site 663278004724 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 663278004725 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 663278004726 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 663278004727 Phosphoglycerate kinase; Region: PGK; pfam00162 663278004728 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 663278004729 substrate binding site [chemical binding]; other site 663278004730 hinge regions; other site 663278004731 ADP binding site [chemical binding]; other site 663278004732 catalytic site [active] 663278004733 triosephosphate isomerase; Provisional; Region: PRK14567 663278004734 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 663278004735 substrate binding site [chemical binding]; other site 663278004736 dimer interface [polypeptide binding]; other site 663278004737 catalytic triad [active] 663278004738 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 663278004739 phosphoglyceromutase; Provisional; Region: PRK05434 663278004740 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 663278004741 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 663278004742 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 663278004743 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 663278004744 nucleoside/Zn binding site; other site 663278004745 dimer interface [polypeptide binding]; other site 663278004746 catalytic motif [active] 663278004747 CAAX protease self-immunity; Region: Abi; pfam02517 663278004748 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 663278004749 GYD domain; Region: GYD; cl01743 663278004750 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 663278004751 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 663278004752 active site 663278004753 catalytic residues [active] 663278004754 metal binding site [ion binding]; metal-binding site 663278004755 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 663278004756 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 663278004757 dimer interface [polypeptide binding]; other site 663278004758 [2Fe-2S] cluster binding site [ion binding]; other site 663278004759 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278004760 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 663278004761 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 663278004762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278004763 FeS/SAM binding site; other site 663278004764 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 663278004765 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 663278004766 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278004767 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278004768 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 663278004769 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278004770 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 663278004771 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 663278004772 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278004773 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278004774 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 663278004775 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 663278004776 nitrogenase iron protein; Region: nifH; TIGR01287 663278004777 Nucleotide-binding sites [chemical binding]; other site 663278004778 Walker A motif; other site 663278004779 Switch I region of nucleotide binding site; other site 663278004780 Fe4S4 binding sites [ion binding]; other site 663278004781 Switch II region of nucleotide binding site; other site 663278004782 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 663278004783 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 663278004784 Walker A/P-loop; other site 663278004785 ATP binding site [chemical binding]; other site 663278004786 Q-loop/lid; other site 663278004787 ABC transporter signature motif; other site 663278004788 Walker B; other site 663278004789 D-loop; other site 663278004790 H-loop/switch region; other site 663278004791 molybdenum-pterin binding domain; Region: Mop; TIGR00638 663278004792 Helix-turn-helix domain; Region: HTH_17; pfam12728 663278004793 PBP superfamily domain; Region: PBP_like; pfam12727 663278004794 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 663278004795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 663278004796 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 663278004797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278004798 dimer interface [polypeptide binding]; other site 663278004799 conserved gate region; other site 663278004800 putative PBP binding loops; other site 663278004801 ABC-ATPase subunit interface; other site 663278004802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278004803 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 663278004804 Walker A/P-loop; other site 663278004805 ATP binding site [chemical binding]; other site 663278004806 Q-loop/lid; other site 663278004807 ABC transporter signature motif; other site 663278004808 Walker B; other site 663278004809 D-loop; other site 663278004810 H-loop/switch region; other site 663278004811 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 663278004812 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 663278004813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 663278004814 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 663278004815 dimer interface [polypeptide binding]; other site 663278004816 active site 663278004817 metal binding site [ion binding]; metal-binding site 663278004818 glutathione binding site [chemical binding]; other site 663278004819 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 663278004820 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 663278004821 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 663278004822 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 663278004823 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 663278004824 putative FMN binding site [chemical binding]; other site 663278004825 Rrf2 family protein; Region: rrf2_super; TIGR00738 663278004826 Transcriptional regulator; Region: Rrf2; pfam02082 663278004827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 663278004828 Lysozyme-like; Region: Lysozyme_like; pfam13702 663278004829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 663278004830 Terminase-like family; Region: Terminase_6; pfam03237 663278004831 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 663278004832 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 663278004833 Phage tail protein; Region: Sipho_tail; cl17486 663278004834 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 663278004835 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278004836 active site 663278004837 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 663278004838 active site 663278004839 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 663278004840 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 663278004841 dimer interface [polypeptide binding]; other site 663278004842 catalytic residues [active] 663278004843 Uncharacterized conserved protein [Function unknown]; Region: COG1624 663278004844 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 663278004845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 663278004846 FAD dependent oxidoreductase; Region: DAO; pfam01266 663278004847 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 663278004848 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 663278004849 active site 663278004850 homodimer interface [polypeptide binding]; other site 663278004851 Predicted membrane protein [General function prediction only]; Region: COG4194 663278004852 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 663278004853 agmatinase; Region: agmatinase; TIGR01230 663278004854 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 663278004855 putative active site [active] 663278004856 Mn binding site [ion binding]; other site 663278004857 spermidine synthase; Provisional; Region: PRK00811 663278004858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278004859 S-adenosylmethionine binding site [chemical binding]; other site 663278004860 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 663278004861 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 663278004862 dimer interface [polypeptide binding]; other site 663278004863 FMN binding site [chemical binding]; other site 663278004864 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278004865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278004866 metal binding site [ion binding]; metal-binding site 663278004867 active site 663278004868 I-site; other site 663278004869 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 663278004870 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 663278004871 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 663278004872 generic binding surface II; other site 663278004873 generic binding surface I; other site 663278004874 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 663278004875 active site 663278004876 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 663278004877 active site 663278004878 catalytic site [active] 663278004879 substrate binding site [chemical binding]; other site 663278004880 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 663278004881 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 663278004882 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 663278004883 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 663278004884 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 663278004885 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 663278004886 active site 663278004887 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 663278004888 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 663278004889 putative substrate binding region [chemical binding]; other site 663278004890 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 663278004891 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 663278004892 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 663278004893 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 663278004894 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 663278004895 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 663278004896 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 663278004897 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 663278004898 catalytic residue [active] 663278004899 putative FPP diphosphate binding site; other site 663278004900 putative FPP binding hydrophobic cleft; other site 663278004901 dimer interface [polypeptide binding]; other site 663278004902 putative IPP diphosphate binding site; other site 663278004903 ribosome recycling factor; Reviewed; Region: frr; PRK00083 663278004904 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 663278004905 hinge region; other site 663278004906 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 663278004907 putative nucleotide binding site [chemical binding]; other site 663278004908 uridine monophosphate binding site [chemical binding]; other site 663278004909 homohexameric interface [polypeptide binding]; other site 663278004910 elongation factor Ts; Provisional; Region: tsf; PRK09377 663278004911 UBA/TS-N domain; Region: UBA; pfam00627 663278004912 Elongation factor TS; Region: EF_TS; pfam00889 663278004913 Elongation factor TS; Region: EF_TS; pfam00889 663278004914 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 663278004915 rRNA interaction site [nucleotide binding]; other site 663278004916 S8 interaction site; other site 663278004917 putative laminin-1 binding site; other site 663278004918 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 663278004919 sporulation sigma factor SigG; Reviewed; Region: PRK08215 663278004920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278004921 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 663278004922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278004923 DNA binding residues [nucleotide binding] 663278004924 sporulation sigma factor SigE; Reviewed; Region: PRK08301 663278004925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278004926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278004927 DNA binding residues [nucleotide binding] 663278004928 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 663278004929 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 663278004930 MFS/sugar transport protein; Region: MFS_2; pfam13347 663278004931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278004932 chaperone protein DnaJ; Provisional; Region: PRK10767 663278004933 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 663278004934 HSP70 interaction site [polypeptide binding]; other site 663278004935 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 663278004936 substrate binding site [polypeptide binding]; other site 663278004937 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 663278004938 Zn binding sites [ion binding]; other site 663278004939 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 663278004940 dimer interface [polypeptide binding]; other site 663278004941 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 663278004942 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 663278004943 nucleotide binding site [chemical binding]; other site 663278004944 NEF interaction site [polypeptide binding]; other site 663278004945 SBD interface [polypeptide binding]; other site 663278004946 GrpE; Region: GrpE; pfam01025 663278004947 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 663278004948 dimer interface [polypeptide binding]; other site 663278004949 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 663278004950 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 663278004951 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 663278004952 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 663278004953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278004954 FeS/SAM binding site; other site 663278004955 HemN C-terminal domain; Region: HemN_C; pfam06969 663278004956 GTP-binding protein LepA; Provisional; Region: PRK05433 663278004957 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 663278004958 G1 box; other site 663278004959 putative GEF interaction site [polypeptide binding]; other site 663278004960 GTP/Mg2+ binding site [chemical binding]; other site 663278004961 Switch I region; other site 663278004962 G2 box; other site 663278004963 G3 box; other site 663278004964 Switch II region; other site 663278004965 G4 box; other site 663278004966 G5 box; other site 663278004967 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 663278004968 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 663278004969 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 663278004970 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 663278004971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278004972 S-adenosylmethionine binding site [chemical binding]; other site 663278004973 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 663278004974 active site 663278004975 catalytic motif [active] 663278004976 Zn binding site [ion binding]; other site 663278004977 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 663278004978 16S/18S rRNA binding site [nucleotide binding]; other site 663278004979 S13e-L30e interaction site [polypeptide binding]; other site 663278004980 25S rRNA binding site [nucleotide binding]; other site 663278004981 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 663278004982 active site 663278004983 catalytic site [active] 663278004984 competence damage-inducible protein A; Provisional; Region: PRK00549 663278004985 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 663278004986 putative MPT binding site; other site 663278004987 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 663278004988 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 663278004989 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 663278004990 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 663278004991 Ligand Binding Site [chemical binding]; other site 663278004992 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 663278004993 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 663278004994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278004995 catalytic residue [active] 663278004996 CTP synthetase; Validated; Region: pyrG; PRK05380 663278004997 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 663278004998 Catalytic site [active] 663278004999 active site 663278005000 UTP binding site [chemical binding]; other site 663278005001 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 663278005002 active site 663278005003 putative oxyanion hole; other site 663278005004 catalytic triad [active] 663278005005 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 663278005006 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 663278005007 putative active site [active] 663278005008 metal binding site [ion binding]; metal-binding site 663278005009 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 663278005010 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 663278005011 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 663278005012 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 663278005013 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 663278005014 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 663278005015 homodimer interface [polypeptide binding]; other site 663278005016 NADP binding site [chemical binding]; other site 663278005017 substrate binding site [chemical binding]; other site 663278005018 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 663278005019 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 663278005020 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 663278005021 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 663278005022 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 663278005023 GTPase CgtA; Reviewed; Region: obgE; PRK12297 663278005024 GTP1/OBG; Region: GTP1_OBG; pfam01018 663278005025 Obg GTPase; Region: Obg; cd01898 663278005026 G1 box; other site 663278005027 GTP/Mg2+ binding site [chemical binding]; other site 663278005028 Switch I region; other site 663278005029 G2 box; other site 663278005030 G3 box; other site 663278005031 Switch II region; other site 663278005032 G4 box; other site 663278005033 G5 box; other site 663278005034 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 663278005035 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 663278005036 dimerization interface [polypeptide binding]; other site 663278005037 active site 663278005038 metal binding site [ion binding]; metal-binding site 663278005039 Uncharacterized conserved protein [Function unknown]; Region: COG1284 663278005040 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 663278005041 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 663278005042 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 663278005043 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 663278005044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278005045 FeS/SAM binding site; other site 663278005046 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 663278005047 Pyruvate formate lyase 1; Region: PFL1; cd01678 663278005048 coenzyme A binding site [chemical binding]; other site 663278005049 active site 663278005050 catalytic residues [active] 663278005051 glycine loop; other site 663278005052 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278005053 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 663278005054 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 663278005055 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 663278005056 intersubunit interface [polypeptide binding]; other site 663278005057 active site 663278005058 catalytic residue [active] 663278005059 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 663278005060 NlpC/P60 family; Region: NLPC_P60; pfam00877 663278005061 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278005062 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 663278005063 catalytic residues [active] 663278005064 catalytic nucleophile [active] 663278005065 Recombinase; Region: Recombinase; pfam07508 663278005066 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 663278005067 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278005068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278005069 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278005070 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278005071 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278005072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278005073 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278005074 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 663278005075 MT-A70; Region: MT-A70; cl01947 663278005076 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278005077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278005078 non-specific DNA binding site [nucleotide binding]; other site 663278005079 salt bridge; other site 663278005080 sequence-specific DNA binding site [nucleotide binding]; other site 663278005081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278005082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278005083 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 663278005084 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 663278005085 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 663278005086 dinuclear metal binding motif [ion binding]; other site 663278005087 Predicted membrane protein [Function unknown]; Region: COG2323 663278005088 Predicted membrane protein [Function unknown]; Region: COG2323 663278005089 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 663278005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278005091 S-adenosylmethionine binding site [chemical binding]; other site 663278005092 Predicted periplasmic protein [Function unknown]; Region: COG3698 663278005093 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 663278005094 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278005095 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278005096 active site 663278005097 metal binding site [ion binding]; metal-binding site 663278005098 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 663278005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278005100 putative substrate translocation pore; other site 663278005101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278005102 putative DNA binding site [nucleotide binding]; other site 663278005103 dimerization interface [polypeptide binding]; other site 663278005104 putative Zn2+ binding site [ion binding]; other site 663278005105 transposase/IS protein; Provisional; Region: PRK09183 663278005106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278005107 Walker A motif; other site 663278005108 ATP binding site [chemical binding]; other site 663278005109 Walker B motif; other site 663278005110 Helix-turn-helix domain; Region: HTH_17; pfam12728 663278005111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278005112 non-specific DNA binding site [nucleotide binding]; other site 663278005113 salt bridge; other site 663278005114 sequence-specific DNA binding site [nucleotide binding]; other site 663278005115 GMP synthase; Reviewed; Region: guaA; PRK00074 663278005116 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 663278005117 AMP/PPi binding site [chemical binding]; other site 663278005118 candidate oxyanion hole; other site 663278005119 catalytic triad [active] 663278005120 potential glutamine specificity residues [chemical binding]; other site 663278005121 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 663278005122 ATP Binding subdomain [chemical binding]; other site 663278005123 Dimerization subdomain; other site 663278005124 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 663278005125 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 663278005126 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 663278005127 Potassium binding sites [ion binding]; other site 663278005128 Cesium cation binding sites [ion binding]; other site 663278005129 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 663278005130 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 663278005131 Glycoprotease family; Region: Peptidase_M22; pfam00814 663278005132 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 663278005133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278005134 active site 663278005135 NAD-dependent deacetylase; Provisional; Region: PRK00481 663278005136 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 663278005137 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 663278005138 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 663278005139 catalytic triad [active] 663278005140 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 663278005141 PGAP1-like protein; Region: PGAP1; pfam07819 663278005142 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 663278005143 active site 663278005144 Zn binding site [ion binding]; other site 663278005145 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 663278005146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 663278005147 ABC-ATPase subunit interface; other site 663278005148 dimer interface [polypeptide binding]; other site 663278005149 putative PBP binding regions; other site 663278005150 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 663278005151 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 663278005152 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 663278005153 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 663278005154 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278005155 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 663278005156 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278005157 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 663278005158 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 663278005159 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 663278005160 dimer interface [polypeptide binding]; other site 663278005161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278005162 catalytic residue [active] 663278005163 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 663278005164 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 663278005165 homodimer interface [polypeptide binding]; other site 663278005166 substrate-cofactor binding pocket; other site 663278005167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278005168 catalytic residue [active] 663278005169 cystathionine beta-lyase; Provisional; Region: PRK07671 663278005170 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 663278005171 homodimer interface [polypeptide binding]; other site 663278005172 substrate-cofactor binding pocket; other site 663278005173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278005174 catalytic residue [active] 663278005175 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 663278005176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278005177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278005178 homodimer interface [polypeptide binding]; other site 663278005179 catalytic residue [active] 663278005180 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 663278005181 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 663278005182 active site 663278005183 NAD binding site [chemical binding]; other site 663278005184 metal binding site [ion binding]; metal-binding site 663278005185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278005186 dimer interface [polypeptide binding]; other site 663278005187 conserved gate region; other site 663278005188 ABC-ATPase subunit interface; other site 663278005189 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 663278005190 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 663278005191 Walker A/P-loop; other site 663278005192 ATP binding site [chemical binding]; other site 663278005193 Q-loop/lid; other site 663278005194 ABC transporter signature motif; other site 663278005195 Walker B; other site 663278005196 D-loop; other site 663278005197 H-loop/switch region; other site 663278005198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 663278005199 NIL domain; Region: NIL; pfam09383 663278005200 transaminase; Reviewed; Region: PRK08068 663278005201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278005203 homodimer interface [polypeptide binding]; other site 663278005204 catalytic residue [active] 663278005205 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 663278005206 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 663278005207 molybdenum-pterin binding domain; Region: Mop; TIGR00638 663278005208 TOBE domain; Region: TOBE; cl01440 663278005209 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 663278005210 classical (c) SDRs; Region: SDR_c; cd05233 663278005211 NAD(P) binding site [chemical binding]; other site 663278005212 active site 663278005213 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 663278005214 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 663278005215 Ligand binding site; other site 663278005216 Putative Catalytic site; other site 663278005217 DXD motif; other site 663278005218 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 663278005219 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 663278005220 dimer interface [polypeptide binding]; other site 663278005221 active site 663278005222 metal binding site [ion binding]; metal-binding site 663278005223 Uncharacterized conserved protein [Function unknown]; Region: COG1284 663278005224 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 663278005225 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 663278005226 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 663278005227 DEAD-like helicases superfamily; Region: DEXDc; smart00487 663278005228 ATP binding site [chemical binding]; other site 663278005229 Mg++ binding site [ion binding]; other site 663278005230 motif III; other site 663278005231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278005232 nucleotide binding region [chemical binding]; other site 663278005233 ATP-binding site [chemical binding]; other site 663278005234 Arc-like DNA binding domain; Region: Arc; pfam03869 663278005235 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 663278005236 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 663278005237 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 663278005238 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 663278005239 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 663278005240 hybrid cluster protein; Provisional; Region: PRK05290 663278005241 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 663278005242 ACS interaction site; other site 663278005243 CODH interaction site; other site 663278005244 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 663278005245 hybrid metal cluster; other site 663278005246 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 663278005247 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 663278005248 ligand binding site [chemical binding]; other site 663278005249 flexible hinge region; other site 663278005250 putative switch regulator; other site 663278005251 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 663278005252 non-specific DNA interactions [nucleotide binding]; other site 663278005253 DNA binding site [nucleotide binding] 663278005254 sequence specific DNA binding site [nucleotide binding]; other site 663278005255 putative cAMP binding site [chemical binding]; other site 663278005256 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 663278005257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278005258 FeS/SAM binding site; other site 663278005259 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 663278005260 NMT1-like family; Region: NMT1_2; pfam13379 663278005261 NMT1/THI5 like; Region: NMT1; pfam09084 663278005262 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 663278005263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278005264 dimer interface [polypeptide binding]; other site 663278005265 conserved gate region; other site 663278005266 putative PBP binding loops; other site 663278005267 ABC-ATPase subunit interface; other site 663278005268 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 663278005269 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 663278005270 Walker A/P-loop; other site 663278005271 ATP binding site [chemical binding]; other site 663278005272 Q-loop/lid; other site 663278005273 ABC transporter signature motif; other site 663278005274 Walker B; other site 663278005275 D-loop; other site 663278005276 H-loop/switch region; other site 663278005277 Transposase IS200 like; Region: Y1_Tnp; pfam01797 663278005278 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 663278005279 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 663278005280 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 663278005281 Ligand Binding Site [chemical binding]; other site 663278005282 K+-transporting ATPase, c chain; Region: KdpC; cl00944 663278005283 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 663278005284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278005285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278005286 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 663278005287 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 663278005288 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 663278005289 NlpC/P60 family; Region: NLPC_P60; pfam00877 663278005290 AAA-like domain; Region: AAA_10; pfam12846 663278005291 Domain of unknown function DUF87; Region: DUF87; pfam01935 663278005292 PrgI family protein; Region: PrgI; pfam12666 663278005293 MT-A70; Region: MT-A70; cl01947 663278005294 SpoVG; Region: SpoVG; pfam04026 663278005295 Maff2 family; Region: Maff2; pfam12750 663278005296 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 663278005297 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278005298 Walker A motif; other site 663278005299 ATP binding site [chemical binding]; other site 663278005300 Walker B motif; other site 663278005301 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 663278005302 Antirestriction protein (ArdA); Region: ArdA; pfam07275 663278005303 ParB-like nuclease domain; Region: ParBc; pfam02195 663278005304 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 663278005305 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 663278005306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278005307 dimerization interface [polypeptide binding]; other site 663278005308 putative DNA binding site [nucleotide binding]; other site 663278005309 putative Zn2+ binding site [ion binding]; other site 663278005310 AsnC family; Region: AsnC_trans_reg; pfam01037 663278005311 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 663278005312 Uncharacterized conserved protein [Function unknown]; Region: COG1434 663278005313 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 663278005314 putative active site [active] 663278005315 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 663278005316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278005317 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 663278005318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278005319 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 663278005320 Melibiase; Region: Melibiase; pfam02065 663278005321 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 663278005322 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 663278005323 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 663278005324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278005325 dimer interface [polypeptide binding]; other site 663278005326 conserved gate region; other site 663278005327 putative PBP binding loops; other site 663278005328 ABC-ATPase subunit interface; other site 663278005329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 663278005330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278005331 dimer interface [polypeptide binding]; other site 663278005332 conserved gate region; other site 663278005333 putative PBP binding loops; other site 663278005334 ABC-ATPase subunit interface; other site 663278005335 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 663278005336 galactokinase; Provisional; Region: PRK03817 663278005337 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 663278005338 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 663278005339 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 663278005340 dimer interface [polypeptide binding]; other site 663278005341 active site 663278005342 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 663278005343 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 663278005344 active site 663278005345 homodimer interface [polypeptide binding]; other site 663278005346 catalytic site [active] 663278005347 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 663278005348 RelB antitoxin; Region: RelB; cl01171 663278005349 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278005350 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 663278005351 catalytic residues [active] 663278005352 catalytic nucleophile [active] 663278005353 Recombinase; Region: Recombinase; pfam07508 663278005354 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278005355 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 663278005356 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 663278005357 AAA domain; Region: AAA_25; pfam13481 663278005358 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278005359 Walker A motif; other site 663278005360 ATP binding site [chemical binding]; other site 663278005361 Walker B motif; other site 663278005362 cysteine proteinase; Provisional; Region: PTZ00200 663278005363 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 663278005364 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 663278005365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278005366 ATP binding site [chemical binding]; other site 663278005367 putative Mg++ binding site [ion binding]; other site 663278005368 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 663278005369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278005370 S-adenosylmethionine binding site [chemical binding]; other site 663278005371 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 663278005372 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 663278005373 Protein of unknown function DUF262; Region: DUF262; pfam03235 663278005374 Uncharacterized conserved protein [Function unknown]; Region: COG1479 663278005375 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 663278005376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278005377 ATP binding site [chemical binding]; other site 663278005378 putative Mg++ binding site [ion binding]; other site 663278005379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278005380 nucleotide binding region [chemical binding]; other site 663278005381 ATP-binding site [chemical binding]; other site 663278005382 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 663278005383 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 663278005384 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 663278005385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278005386 ATP binding site [chemical binding]; other site 663278005387 putative Mg++ binding site [ion binding]; other site 663278005388 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 663278005389 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 663278005390 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 663278005391 HsdM N-terminal domain; Region: HsdM_N; pfam12161 663278005392 Methyltransferase domain; Region: Methyltransf_26; pfam13659 663278005393 DNA binding domain, excisionase family; Region: excise; TIGR01764 663278005394 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 663278005395 HTH DNA binding domain; Region: HTH_10; pfam04967 663278005396 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 663278005397 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 663278005398 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 663278005399 DNA binding site [nucleotide binding] 663278005400 active site 663278005401 catalytic site [active] 663278005402 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 663278005403 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 663278005404 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 663278005405 VRR-NUC domain; Region: VRR_NUC; pfam08774 663278005406 MYM-type Zinc finger with FCS sequence motif; Region: zf-FCS; pfam06467 663278005407 HNH endonuclease; Region: HNH_3; pfam13392 663278005408 DEAD-like helicases superfamily; Region: DEXDc; smart00487 663278005409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278005410 ATP binding site [chemical binding]; other site 663278005411 putative Mg++ binding site [ion binding]; other site 663278005412 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 663278005413 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278005414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278005415 DNA binding residues [nucleotide binding] 663278005416 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 663278005417 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 663278005418 active site 663278005419 Phage terminase, small subunit; Region: Terminase_4; cl01525 663278005420 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 663278005421 ParB-like nuclease domain; Region: ParBc; pfam02195 663278005422 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 663278005423 DNA methylase; Region: N6_N4_Mtase; pfam01555 663278005424 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 663278005425 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 663278005426 Phage-related protein [Function unknown]; Region: COG4695 663278005427 Phage portal protein; Region: Phage_portal; pfam04860 663278005428 Clp protease; Region: CLP_protease; pfam00574 663278005429 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 663278005430 oligomer interface [polypeptide binding]; other site 663278005431 active site residues [active] 663278005432 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 663278005433 Phage capsid family; Region: Phage_capsid; pfam05065 663278005434 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 663278005435 oligomerization interface [polypeptide binding]; other site 663278005436 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 663278005437 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 663278005438 Phage-related minor tail protein [Function unknown]; Region: COG5280 663278005439 Phage-related protein [Function unknown]; Region: COG5412 663278005440 potential frameshift: common BLAST hit: gi|167630892|ref|YP_001681391.1| phage minor structural protein, n-terminal 663278005441 Phage-related protein [Function unknown]; Region: COG4722 663278005442 Phage tail protein; Region: Sipho_tail; pfam05709 663278005443 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 663278005444 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 663278005445 active site 663278005446 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 663278005447 Holin family; Region: Phage_holin_4; pfam05105 663278005448 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 663278005449 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278005450 active site 663278005451 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 663278005452 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 663278005453 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278005454 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 663278005455 catalytic residues [active] 663278005456 catalytic nucleophile [active] 663278005457 Recombinase; Region: Recombinase; pfam07508 663278005458 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278005459 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278005460 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278005461 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 663278005462 catalytic residues [active] 663278005463 catalytic nucleophile [active] 663278005464 Recombinase; Region: Recombinase; pfam07508 663278005465 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278005466 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 663278005467 HsdM N-terminal domain; Region: HsdM_N; pfam12161 663278005468 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 663278005469 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 663278005470 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 663278005471 transposase/IS protein; Provisional; Region: PRK09183 663278005472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278005473 Walker A motif; other site 663278005474 ATP binding site [chemical binding]; other site 663278005475 Walker B motif; other site 663278005476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278005477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278005478 active site 663278005479 phosphorylation site [posttranslational modification] 663278005480 intermolecular recognition site; other site 663278005481 dimerization interface [polypeptide binding]; other site 663278005482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278005483 DNA binding site [nucleotide binding] 663278005484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278005485 dimer interface [polypeptide binding]; other site 663278005486 phosphorylation site [posttranslational modification] 663278005487 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 663278005488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278005489 ATP binding site [chemical binding]; other site 663278005490 Mg2+ binding site [ion binding]; other site 663278005491 G-X-G motif; other site 663278005492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 663278005493 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 663278005494 Walker A/P-loop; other site 663278005495 ATP binding site [chemical binding]; other site 663278005496 Q-loop/lid; other site 663278005497 ABC transporter signature motif; other site 663278005498 Walker B; other site 663278005499 D-loop; other site 663278005500 H-loop/switch region; other site 663278005501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 663278005502 FtsX-like permease family; Region: FtsX; pfam02687 663278005503 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 663278005504 FtsX-like permease family; Region: FtsX; pfam02687 663278005505 Predicted transcriptional regulators [Transcription]; Region: COG1725 663278005506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278005507 DNA-binding site [nucleotide binding]; DNA binding site 663278005508 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278005509 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 663278005510 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278005511 P-loop; other site 663278005512 Magnesium ion binding site [ion binding]; other site 663278005513 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278005514 Magnesium ion binding site [ion binding]; other site 663278005515 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 663278005516 ParB-like nuclease domain; Region: ParB; smart00470 663278005517 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 663278005518 Helix-turn-helix domain; Region: HTH_36; pfam13730 663278005519 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 663278005520 Low molecular weight phosphatase family; Region: LMWPc; cd00115 663278005521 active site 663278005522 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 663278005523 Ferredoxin [Energy production and conversion]; Region: COG1146 663278005524 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 663278005525 Predicted permeases [General function prediction only]; Region: COG0701 663278005526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278005527 dimerization interface [polypeptide binding]; other site 663278005528 putative DNA binding site [nucleotide binding]; other site 663278005529 putative Zn2+ binding site [ion binding]; other site 663278005530 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 663278005531 AAA-like domain; Region: AAA_10; pfam12846 663278005532 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278005533 Walker A motif; other site 663278005534 ATP binding site [chemical binding]; other site 663278005535 Walker B motif; other site 663278005536 Maff2 family; Region: Maff2; pfam12750 663278005537 PrgI family protein; Region: PrgI; pfam12666 663278005538 AAA-like domain; Region: AAA_10; pfam12846 663278005539 Domain of unknown function DUF87; Region: DUF87; pfam01935 663278005540 LabA_like proteins; Region: LabA_like; cd06167 663278005541 putative metal binding site [ion binding]; other site 663278005542 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 663278005543 NlpC/P60 family; Region: NLPC_P60; pfam00877 663278005544 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 663278005545 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 663278005546 DNA topoisomerase III; Provisional; Region: PRK07726 663278005547 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 663278005548 active site 663278005549 putative interdomain interaction site [polypeptide binding]; other site 663278005550 putative metal-binding site [ion binding]; other site 663278005551 putative nucleotide binding site [chemical binding]; other site 663278005552 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 663278005553 domain I; other site 663278005554 DNA binding groove [nucleotide binding] 663278005555 phosphate binding site [ion binding]; other site 663278005556 domain II; other site 663278005557 domain III; other site 663278005558 nucleotide binding site [chemical binding]; other site 663278005559 catalytic site [active] 663278005560 domain IV; other site 663278005561 YodL-like; Region: YodL; pfam14191 663278005562 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 663278005563 Domain of unknown function (DUF4319); Region: DUF4319; pfam14203 663278005564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 663278005565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278005566 Coenzyme A binding pocket [chemical binding]; other site 663278005567 Methyltransferase domain; Region: Methyltransf_26; pfam13659 663278005568 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 663278005569 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 663278005570 DEAD-like helicases superfamily; Region: DEXDc; smart00487 663278005571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278005572 ATP binding site [chemical binding]; other site 663278005573 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 663278005574 helicase superfamily c-terminal domain; Region: HELICc; smart00490 663278005575 Protein of unknown function (DUF3849); Region: DUF3849; pfam12960 663278005576 Abortive infection C-terminus; Region: Abi_C; pfam14355 663278005577 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 663278005578 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 663278005579 sequence-specific DNA binding site [nucleotide binding]; other site 663278005580 salt bridge; other site 663278005581 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 663278005582 TIR domain; Region: TIR_2; pfam13676 663278005583 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 663278005584 DNA methylase; Region: N6_N4_Mtase; pfam01555 663278005585 DNA methylase; Region: N6_N4_Mtase; cl17433 663278005586 Domain of unknown function (DUF955); Region: DUF955; pfam06114 663278005587 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 663278005588 putative active site [active] 663278005589 Restriction endonuclease [Defense mechanisms]; Region: COG3587 663278005590 Helix-turn-helix domain; Region: HTH_17; pfam12728 663278005591 Predicted membrane protein [Function unknown]; Region: COG2510 663278005592 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 663278005593 Predicted membrane protein [Function unknown]; Region: COG2510 663278005594 Bacitracin resistance protein BacA; Region: BacA; pfam02673 663278005595 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 663278005596 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278005597 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278005598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278005599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278005600 dimerization interface [polypeptide binding]; other site 663278005601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278005602 dimer interface [polypeptide binding]; other site 663278005603 phosphorylation site [posttranslational modification] 663278005604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278005605 ATP binding site [chemical binding]; other site 663278005606 Mg2+ binding site [ion binding]; other site 663278005607 G-X-G motif; other site 663278005608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278005610 active site 663278005611 phosphorylation site [posttranslational modification] 663278005612 intermolecular recognition site; other site 663278005613 dimerization interface [polypeptide binding]; other site 663278005614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278005615 DNA binding site [nucleotide binding] 663278005616 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278005617 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 663278005618 DNA binding residues [nucleotide binding] 663278005619 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 663278005620 hybrid cluster protein; Provisional; Region: PRK05290 663278005621 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 663278005622 ACS interaction site; other site 663278005623 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 663278005624 hybrid metal cluster; other site 663278005625 Rubredoxin [Energy production and conversion]; Region: COG1773 663278005626 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 663278005627 iron binding site [ion binding]; other site 663278005628 Cupin domain; Region: Cupin_2; cl17218 663278005629 Ferredoxin [Energy production and conversion]; Region: COG1146 663278005630 4Fe-4S binding domain; Region: Fer4_6; pfam12837 663278005631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 663278005632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 663278005633 ligand binding site [chemical binding]; other site 663278005634 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 663278005635 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 663278005636 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 663278005637 ligand binding site [chemical binding]; other site 663278005638 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 663278005639 non-specific DNA interactions [nucleotide binding]; other site 663278005640 DNA binding site [nucleotide binding] 663278005641 sequence specific DNA binding site [nucleotide binding]; other site 663278005642 putative cAMP binding site [chemical binding]; other site 663278005643 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 663278005644 4Fe-4S binding domain; Region: Fer4_5; pfam12801 663278005645 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 663278005646 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 663278005647 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 663278005648 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 663278005649 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278005650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278005651 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278005652 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278005653 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278005654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278005655 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278005656 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 663278005657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278005658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278005659 non-specific DNA binding site [nucleotide binding]; other site 663278005660 salt bridge; other site 663278005661 sequence-specific DNA binding site [nucleotide binding]; other site 663278005662 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278005663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278005664 DNA binding residues [nucleotide binding] 663278005665 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278005666 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 663278005667 catalytic residues [active] 663278005668 catalytic nucleophile [active] 663278005669 Recombinase; Region: Recombinase; pfam07508 663278005670 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278005671 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 663278005672 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 663278005673 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 663278005674 catalytic residues [active] 663278005675 catalytic nucleophile [active] 663278005676 Recombinase; Region: Recombinase; pfam07508 663278005677 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 663278005678 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 663278005679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 663278005680 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 663278005681 NlpC/P60 family; Region: NLPC_P60; pfam00877 663278005682 NAD synthetase; Reviewed; Region: nadE; PRK02628 663278005683 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 663278005684 multimer interface [polypeptide binding]; other site 663278005685 active site 663278005686 catalytic triad [active] 663278005687 protein interface 1 [polypeptide binding]; other site 663278005688 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 663278005689 homodimer interface [polypeptide binding]; other site 663278005690 NAD binding pocket [chemical binding]; other site 663278005691 ATP binding pocket [chemical binding]; other site 663278005692 Mg binding site [ion binding]; other site 663278005693 active-site loop [active] 663278005694 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 663278005695 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 663278005696 active site 663278005697 Uncharacterized conserved protein [Function unknown]; Region: COG0062 663278005698 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 663278005699 putative substrate binding site [chemical binding]; other site 663278005700 putative ATP binding site [chemical binding]; other site 663278005701 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 663278005702 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 663278005703 dinuclear metal binding motif [ion binding]; other site 663278005704 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 663278005705 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 663278005706 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278005707 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 663278005708 nudix motif; other site 663278005709 hypothetical protein; Provisional; Region: PRK05473 663278005710 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 663278005711 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 663278005712 putative tRNA-binding site [nucleotide binding]; other site 663278005713 B3/4 domain; Region: B3_4; pfam03483 663278005714 tRNA synthetase B5 domain; Region: B5; smart00874 663278005715 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 663278005716 dimer interface [polypeptide binding]; other site 663278005717 motif 1; other site 663278005718 motif 3; other site 663278005719 motif 2; other site 663278005720 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 663278005721 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 663278005722 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 663278005723 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 663278005724 dimer interface [polypeptide binding]; other site 663278005725 motif 1; other site 663278005726 active site 663278005727 motif 2; other site 663278005728 motif 3; other site 663278005729 PAS fold; Region: PAS; pfam00989 663278005730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278005731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278005732 metal binding site [ion binding]; metal-binding site 663278005733 active site 663278005734 I-site; other site 663278005735 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 663278005736 MutS domain III; Region: MutS_III; pfam05192 663278005737 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 663278005738 Walker A/P-loop; other site 663278005739 ATP binding site [chemical binding]; other site 663278005740 Q-loop/lid; other site 663278005741 ABC transporter signature motif; other site 663278005742 Walker B; other site 663278005743 D-loop; other site 663278005744 H-loop/switch region; other site 663278005745 Smr domain; Region: Smr; pfam01713 663278005746 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 663278005747 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 663278005748 GDP-binding site [chemical binding]; other site 663278005749 ACT binding site; other site 663278005750 IMP binding site; other site 663278005751 Rubrerythrin [Energy production and conversion]; Region: COG1592 663278005752 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 663278005753 binuclear metal center [ion binding]; other site 663278005754 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 663278005755 iron binding site [ion binding]; other site 663278005756 ferric uptake regulator; Provisional; Region: fur; PRK09462 663278005757 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 663278005758 metal binding site 2 [ion binding]; metal-binding site 663278005759 putative DNA binding helix; other site 663278005760 metal binding site 1 [ion binding]; metal-binding site 663278005761 dimer interface [polypeptide binding]; other site 663278005762 structural Zn2+ binding site [ion binding]; other site 663278005763 heat shock protein 90; Provisional; Region: PRK05218 663278005764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278005765 ATP binding site [chemical binding]; other site 663278005766 Mg2+ binding site [ion binding]; other site 663278005767 G-X-G motif; other site 663278005768 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 663278005769 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 663278005770 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 663278005771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278005772 FeS/SAM binding site; other site 663278005773 recombination regulator RecX; Reviewed; Region: recX; PRK00117 663278005774 recombinase A; Provisional; Region: recA; PRK09354 663278005775 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 663278005776 hexamer interface [polypeptide binding]; other site 663278005777 Walker A motif; other site 663278005778 ATP binding site [chemical binding]; other site 663278005779 Walker B motif; other site 663278005780 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 663278005781 MarR family; Region: MarR_2; pfam12802 663278005782 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 663278005783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278005784 putative substrate translocation pore; other site 663278005785 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 663278005786 Aluminium resistance protein; Region: Alum_res; pfam06838 663278005787 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 663278005788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278005789 S-adenosylmethionine binding site [chemical binding]; other site 663278005790 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 663278005791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278005792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278005793 dimerization interface [polypeptide binding]; other site 663278005794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278005795 dimer interface [polypeptide binding]; other site 663278005796 phosphorylation site [posttranslational modification] 663278005797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278005798 ATP binding site [chemical binding]; other site 663278005799 Mg2+ binding site [ion binding]; other site 663278005800 G-X-G motif; other site 663278005801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278005802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278005803 active site 663278005804 phosphorylation site [posttranslational modification] 663278005805 intermolecular recognition site; other site 663278005806 dimerization interface [polypeptide binding]; other site 663278005807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278005808 DNA binding site [nucleotide binding] 663278005809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278005810 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 663278005811 active site 663278005812 motif I; other site 663278005813 motif II; other site 663278005814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278005815 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 663278005816 Domain of unknown function DUF; Region: DUF204; pfam02659 663278005817 glycogen branching enzyme; Provisional; Region: PRK12313 663278005818 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 663278005819 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 663278005820 active site 663278005821 catalytic site [active] 663278005822 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 663278005823 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 663278005824 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 663278005825 ligand binding site; other site 663278005826 oligomer interface; other site 663278005827 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 663278005828 dimer interface [polypeptide binding]; other site 663278005829 N-terminal domain interface [polypeptide binding]; other site 663278005830 sulfate 1 binding site; other site 663278005831 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 663278005832 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 663278005833 ligand binding site; other site 663278005834 oligomer interface; other site 663278005835 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 663278005836 dimer interface [polypeptide binding]; other site 663278005837 N-terminal domain interface [polypeptide binding]; other site 663278005838 sulfate 1 binding site; other site 663278005839 glycogen synthase; Provisional; Region: glgA; PRK00654 663278005840 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 663278005841 ADP-binding pocket [chemical binding]; other site 663278005842 homodimer interface [polypeptide binding]; other site 663278005843 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 663278005844 homodimer interface [polypeptide binding]; other site 663278005845 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 663278005846 active site pocket [active] 663278005847 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 663278005848 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 663278005849 active site 663278005850 homodimer interface [polypeptide binding]; other site 663278005851 catalytic site [active] 663278005852 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 663278005853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278005854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278005855 non-specific DNA binding site [nucleotide binding]; other site 663278005856 salt bridge; other site 663278005857 sequence-specific DNA binding site [nucleotide binding]; other site 663278005858 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278005859 active site 663278005860 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 663278005861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278005862 active site 663278005863 Tetratricopeptide repeat; Region: TPR_16; pfam13432 663278005864 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 663278005865 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 663278005866 active site 663278005867 phosphorylation site [posttranslational modification] 663278005868 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 663278005869 active site 663278005870 P-loop; other site 663278005871 phosphorylation site [posttranslational modification] 663278005872 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 663278005873 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 663278005874 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 663278005875 putative substrate binding site [chemical binding]; other site 663278005876 putative ATP binding site [chemical binding]; other site 663278005877 hypothetical protein; Provisional; Region: PRK13670 663278005878 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 663278005879 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 663278005880 propionate/acetate kinase; Provisional; Region: PRK12379 663278005881 Domain of unknown function (DUF378); Region: DUF378; pfam04070 663278005882 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 663278005883 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 663278005884 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 663278005885 pyridoxal binding site [chemical binding]; other site 663278005886 dimer interface [polypeptide binding]; other site 663278005887 ATP binding site [chemical binding]; other site 663278005888 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 663278005889 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 663278005890 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 663278005891 DXD motif; other site 663278005892 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 663278005893 histidinol-phosphatase; Provisional; Region: PRK05588 663278005894 active site 663278005895 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 663278005896 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 663278005897 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 663278005898 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 663278005899 V-type ATP synthase subunit I; Validated; Region: PRK05771 663278005900 ATP synthase subunit C; Region: ATP-synt_C; cl00466 663278005901 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 663278005902 V-type ATP synthase subunit A; Provisional; Region: PRK04192 663278005903 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 663278005904 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 663278005905 Walker A motif/ATP binding site; other site 663278005906 Walker B motif; other site 663278005907 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 663278005908 V-type ATP synthase subunit B; Provisional; Region: PRK04196 663278005909 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 663278005910 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 663278005911 Walker A motif homologous position; other site 663278005912 Walker B motif; other site 663278005913 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 663278005914 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 663278005915 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 663278005916 Low molecular weight phosphatase family; Region: LMWPc; cd00115 663278005917 active site 663278005918 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 663278005919 Predicted permeases [General function prediction only]; Region: COG0701 663278005920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278005921 dimerization interface [polypeptide binding]; other site 663278005922 putative DNA binding site [nucleotide binding]; other site 663278005923 putative Zn2+ binding site [ion binding]; other site 663278005924 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 663278005925 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 663278005926 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 663278005927 Protein of unknown function (DUF503); Region: DUF503; pfam04456 663278005928 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278005929 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 663278005930 FOG: CBS domain [General function prediction only]; Region: COG0517 663278005931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278005932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278005933 metal binding site [ion binding]; metal-binding site 663278005934 active site 663278005935 I-site; other site 663278005936 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 663278005937 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 663278005938 Methyltransferase domain; Region: Methyltransf_31; pfam13847 663278005939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278005940 S-adenosylmethionine binding site [chemical binding]; other site 663278005941 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 663278005942 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 663278005943 ATP binding site [chemical binding]; other site 663278005944 QueT transporter; Region: QueT; pfam06177 663278005945 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 663278005946 CPxP motif; other site 663278005947 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 663278005948 MPN+ (JAMM) motif; other site 663278005949 Zinc-binding site [ion binding]; other site 663278005950 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 663278005951 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 663278005952 ATP binding site [chemical binding]; other site 663278005953 substrate interface [chemical binding]; other site 663278005954 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 663278005955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 663278005956 nucleotide binding site [chemical binding]; other site 663278005957 Nitroreductase family; Region: Nitroreductase; pfam00881 663278005958 FMN binding site [chemical binding]; other site 663278005959 dimer interface [polypeptide binding]; other site 663278005960 dimer interface [polypeptide binding]; other site 663278005961 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 663278005962 dimer interface [polypeptide binding]; other site 663278005963 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 663278005964 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 663278005965 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 663278005966 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 663278005967 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 663278005968 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 663278005969 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 663278005970 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 663278005971 Cl binding site [ion binding]; other site 663278005972 oligomer interface [polypeptide binding]; other site 663278005973 cell division protein FtsZ; Validated; Region: PRK09330 663278005974 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 663278005975 nucleotide binding site [chemical binding]; other site 663278005976 SulA interaction site; other site 663278005977 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 663278005978 Cell division protein FtsQ; Region: FtsQ; pfam03799 663278005979 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 663278005980 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 663278005981 hinge; other site 663278005982 active site 663278005983 cell division protein FtsW; Region: ftsW; TIGR02614 663278005984 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 663278005985 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 663278005986 Mg++ binding site [ion binding]; other site 663278005987 putative catalytic motif [active] 663278005988 putative substrate binding site [chemical binding]; other site 663278005989 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 663278005990 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 663278005991 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 663278005992 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 663278005993 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 663278005994 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 663278005995 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 663278005996 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 663278005997 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 663278005998 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 663278005999 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 663278006000 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 663278006001 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 663278006002 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 663278006003 MraW methylase family; Region: Methyltransf_5; cl17771 663278006004 cell division protein MraZ; Reviewed; Region: PRK00326 663278006005 MraZ protein; Region: MraZ; pfam02381 663278006006 MraZ protein; Region: MraZ; pfam02381 663278006007 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 663278006008 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 663278006009 active site 663278006010 (T/H)XGH motif; other site 663278006011 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 663278006012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278006013 S-adenosylmethionine binding site [chemical binding]; other site 663278006014 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 663278006015 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 663278006016 GIY-YIG motif/motif A; other site 663278006017 active site 663278006018 catalytic site [active] 663278006019 putative DNA binding site [nucleotide binding]; other site 663278006020 metal binding site [ion binding]; metal-binding site 663278006021 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 663278006022 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278006023 dimerization domain swap beta strand [polypeptide binding]; other site 663278006024 regulatory protein interface [polypeptide binding]; other site 663278006025 active site 663278006026 regulatory phosphorylation site [posttranslational modification]; other site 663278006027 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 663278006028 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 663278006029 RimM N-terminal domain; Region: RimM; pfam01782 663278006030 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 663278006031 KH domain; Region: KH_4; pfam13083 663278006032 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 663278006033 signal recognition particle protein; Provisional; Region: PRK10867 663278006034 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 663278006035 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 663278006036 P loop; other site 663278006037 GTP binding site [chemical binding]; other site 663278006038 Signal peptide binding domain; Region: SRP_SPB; pfam02978 663278006039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278006040 DNA binding residues [nucleotide binding] 663278006041 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 663278006042 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 663278006043 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 663278006044 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 663278006045 putative homodimer interface [polypeptide binding]; other site 663278006046 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 663278006047 heterodimer interface [polypeptide binding]; other site 663278006048 homodimer interface [polypeptide binding]; other site 663278006049 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 663278006050 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 663278006051 23S rRNA interface [nucleotide binding]; other site 663278006052 L7/L12 interface [polypeptide binding]; other site 663278006053 putative thiostrepton binding site; other site 663278006054 L25 interface [polypeptide binding]; other site 663278006055 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 663278006056 mRNA/rRNA interface [nucleotide binding]; other site 663278006057 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 663278006058 23S rRNA interface [nucleotide binding]; other site 663278006059 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 663278006060 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 663278006061 core dimer interface [polypeptide binding]; other site 663278006062 peripheral dimer interface [polypeptide binding]; other site 663278006063 L10 interface [polypeptide binding]; other site 663278006064 L11 interface [polypeptide binding]; other site 663278006065 putative EF-Tu interaction site [polypeptide binding]; other site 663278006066 putative EF-G interaction site [polypeptide binding]; other site 663278006067 O-Antigen ligase; Region: Wzy_C; pfam04932 663278006068 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 663278006069 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 663278006070 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278006071 ATP binding site [chemical binding]; other site 663278006072 putative Mg++ binding site [ion binding]; other site 663278006073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 663278006074 nucleotide binding region [chemical binding]; other site 663278006075 ATP-binding site [chemical binding]; other site 663278006076 TRCF domain; Region: TRCF; pfam03461 663278006077 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 663278006078 putative active site [active] 663278006079 catalytic residue [active] 663278006080 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 663278006081 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 663278006082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278006083 active site 663278006084 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 663278006085 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 663278006086 Substrate binding site; other site 663278006087 Mg++ binding site; other site 663278006088 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 663278006089 active site 663278006090 substrate binding site [chemical binding]; other site 663278006091 CoA binding site [chemical binding]; other site 663278006092 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 663278006093 CheC-like family; Region: CheC; pfam04509 663278006094 CheC-like family; Region: CheC; pfam04509 663278006095 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 663278006096 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 663278006097 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 663278006098 putative active site [active] 663278006099 putative metal binding site [ion binding]; other site 663278006100 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 663278006101 active site 663278006102 metal binding site [ion binding]; metal-binding site 663278006103 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 663278006104 DNA polymerase III, delta subunit; Region: holA; TIGR01128 663278006105 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 663278006106 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 663278006107 Competence protein; Region: Competence; pfam03772 663278006108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278006109 active site 663278006110 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 663278006111 nucleotide binding site/active site [active] 663278006112 HIT family signature motif; other site 663278006113 catalytic residue [active] 663278006114 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 663278006115 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 663278006116 motif 1; other site 663278006117 active site 663278006118 motif 2; other site 663278006119 motif 3; other site 663278006120 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 663278006121 DHHA1 domain; Region: DHHA1; pfam02272 663278006122 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 663278006123 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 663278006124 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 663278006125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278006126 Walker A/P-loop; other site 663278006127 ATP binding site [chemical binding]; other site 663278006128 Q-loop/lid; other site 663278006129 ABC transporter signature motif; other site 663278006130 Walker B; other site 663278006131 D-loop; other site 663278006132 H-loop/switch region; other site 663278006133 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 663278006134 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 663278006135 E-class dimer interface [polypeptide binding]; other site 663278006136 P-class dimer interface [polypeptide binding]; other site 663278006137 active site 663278006138 Cu2+ binding site [ion binding]; other site 663278006139 Zn2+ binding site [ion binding]; other site 663278006140 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 663278006141 putative active site [active] 663278006142 putative metal binding site [ion binding]; other site 663278006143 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 663278006144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278006145 putative substrate translocation pore; other site 663278006146 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 663278006147 active site 663278006148 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 663278006149 dihydropteroate synthase; Region: DHPS; TIGR01496 663278006150 substrate binding pocket [chemical binding]; other site 663278006151 dimer interface [polypeptide binding]; other site 663278006152 inhibitor binding site; inhibition site 663278006153 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 663278006154 homooctamer interface [polypeptide binding]; other site 663278006155 active site 663278006156 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 663278006157 catalytic center binding site [active] 663278006158 ATP binding site [chemical binding]; other site 663278006159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278006160 putative substrate translocation pore; other site 663278006161 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 663278006162 Thiamine pyrophosphokinase; Region: TPK; cd07995 663278006163 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 663278006164 active site 663278006165 dimerization interface [polypeptide binding]; other site 663278006166 thiamine binding site [chemical binding]; other site 663278006167 GTPase RsgA; Reviewed; Region: PRK00098 663278006168 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 663278006169 RNA binding site [nucleotide binding]; other site 663278006170 homodimer interface [polypeptide binding]; other site 663278006171 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 663278006172 GTPase/Zn-binding domain interface [polypeptide binding]; other site 663278006173 GTP/Mg2+ binding site [chemical binding]; other site 663278006174 G4 box; other site 663278006175 G5 box; other site 663278006176 G1 box; other site 663278006177 Switch I region; other site 663278006178 G2 box; other site 663278006179 G3 box; other site 663278006180 Switch II region; other site 663278006181 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 663278006182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 663278006183 active site 663278006184 ATP binding site [chemical binding]; other site 663278006185 substrate binding site [chemical binding]; other site 663278006186 activation loop (A-loop); other site 663278006187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 663278006188 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 663278006189 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 663278006190 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 663278006191 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 663278006192 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 663278006193 Protein phosphatase 2C; Region: PP2C; pfam00481 663278006194 active site 663278006195 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 663278006196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278006197 FeS/SAM binding site; other site 663278006198 NusB family; Region: NusB; pfam01029 663278006199 16S rRNA methyltransferase B; Provisional; Region: PRK14902 663278006200 putative RNA binding site [nucleotide binding]; other site 663278006201 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 663278006202 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 663278006203 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 663278006204 putative active site [active] 663278006205 substrate binding site [chemical binding]; other site 663278006206 putative cosubstrate binding site; other site 663278006207 catalytic site [active] 663278006208 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 663278006209 substrate binding site [chemical binding]; other site 663278006210 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 663278006211 active site 663278006212 catalytic residues [active] 663278006213 metal binding site [ion binding]; metal-binding site 663278006214 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 663278006215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 663278006216 ATP binding site [chemical binding]; other site 663278006217 putative Mg++ binding site [ion binding]; other site 663278006218 helicase superfamily c-terminal domain; Region: HELICc; smart00490 663278006219 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 663278006220 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 663278006221 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 663278006222 catalytic site [active] 663278006223 G-X2-G-X-G-K; other site 663278006224 hypothetical protein; Provisional; Region: PRK04323 663278006225 hypothetical protein; Provisional; Region: PRK11820 663278006226 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 663278006227 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 663278006228 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 663278006229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 663278006230 RNA binding surface [nucleotide binding]; other site 663278006231 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 663278006232 active site 663278006233 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 663278006234 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 663278006235 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 663278006236 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 663278006237 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 663278006238 ScpA/B protein; Region: ScpA_ScpB; cl00598 663278006239 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 663278006240 Peptidase family M50; Region: Peptidase_M50; pfam02163 663278006241 active site 663278006242 putative substrate binding region [chemical binding]; other site 663278006243 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 663278006244 Radical SAM superfamily; Region: Radical_SAM; pfam04055 663278006245 RmuC family; Region: RmuC; pfam02646 663278006246 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 663278006247 Predicted transcriptional regulators [Transcription]; Region: COG1733 663278006248 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 663278006249 YcxB-like protein; Region: YcxB; pfam14317 663278006250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278006251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278006252 active site 663278006253 phosphorylation site [posttranslational modification] 663278006254 intermolecular recognition site; other site 663278006255 dimerization interface [polypeptide binding]; other site 663278006256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278006257 DNA binding site [nucleotide binding] 663278006258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278006259 HAMP domain; Region: HAMP; pfam00672 663278006260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278006261 dimer interface [polypeptide binding]; other site 663278006262 phosphorylation site [posttranslational modification] 663278006263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278006264 ATP binding site [chemical binding]; other site 663278006265 Mg2+ binding site [ion binding]; other site 663278006266 G-X-G motif; other site 663278006267 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 663278006268 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 663278006269 THF binding site; other site 663278006270 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 663278006271 substrate binding site [chemical binding]; other site 663278006272 THF binding site; other site 663278006273 zinc-binding site [ion binding]; other site 663278006274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278006275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278006276 active site 663278006277 phosphorylation site [posttranslational modification] 663278006278 intermolecular recognition site; other site 663278006279 dimerization interface [polypeptide binding]; other site 663278006280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278006281 DNA binding site [nucleotide binding] 663278006282 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 663278006283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278006284 Walker A/P-loop; other site 663278006285 ATP binding site [chemical binding]; other site 663278006286 Q-loop/lid; other site 663278006287 ABC transporter signature motif; other site 663278006288 Walker B; other site 663278006289 D-loop; other site 663278006290 H-loop/switch region; other site 663278006291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 663278006292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278006293 dimer interface [polypeptide binding]; other site 663278006294 phosphorylation site [posttranslational modification] 663278006295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278006296 ATP binding site [chemical binding]; other site 663278006297 Mg2+ binding site [ion binding]; other site 663278006298 G-X-G motif; other site 663278006299 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 663278006300 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278006301 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 663278006302 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 663278006303 MATE family multidrug exporter; Provisional; Region: PRK10189 663278006304 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 663278006305 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 663278006306 active site 663278006307 catalytic triad [active] 663278006308 oxyanion hole [active] 663278006309 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 663278006310 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 663278006311 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 663278006312 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 663278006313 hypothetical protein; Provisional; Region: PRK07208 663278006314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 663278006315 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 663278006316 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 663278006317 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 663278006318 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 663278006319 GTP-binding protein YchF; Reviewed; Region: PRK09601 663278006320 YchF GTPase; Region: YchF; cd01900 663278006321 G1 box; other site 663278006322 GTP/Mg2+ binding site [chemical binding]; other site 663278006323 Switch I region; other site 663278006324 G2 box; other site 663278006325 Switch II region; other site 663278006326 G3 box; other site 663278006327 G4 box; other site 663278006328 G5 box; other site 663278006329 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 663278006330 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 663278006331 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 663278006332 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 663278006333 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 663278006334 Predicted methyltransferases [General function prediction only]; Region: COG0313 663278006335 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 663278006336 putative SAM binding site [chemical binding]; other site 663278006337 putative homodimer interface [polypeptide binding]; other site 663278006338 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 663278006339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 663278006340 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 663278006341 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 663278006342 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 663278006343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278006344 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 663278006345 Walker A motif; other site 663278006346 ATP binding site [chemical binding]; other site 663278006347 Walker B motif; other site 663278006348 Protein of unknown function (DUF970); Region: DUF970; cl17525 663278006349 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 663278006350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278006351 catalytic residue [active] 663278006352 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 663278006353 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 663278006354 active site 663278006355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 663278006356 dimer interface [polypeptide binding]; other site 663278006357 substrate binding site [chemical binding]; other site 663278006358 catalytic residues [active] 663278006359 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 663278006360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 663278006361 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 663278006362 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 663278006363 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 663278006364 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 663278006365 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 663278006366 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278006367 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 663278006368 Soluble P-type ATPase [General function prediction only]; Region: COG4087 663278006369 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 663278006370 Predicted membrane protein [Function unknown]; Region: COG4684 663278006371 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 663278006372 pantothenate kinase; Reviewed; Region: PRK13318 663278006373 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 663278006374 ferric uptake regulator; Provisional; Region: fur; PRK09462 663278006375 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 663278006376 metal binding site 2 [ion binding]; metal-binding site 663278006377 putative DNA binding helix; other site 663278006378 metal binding site 1 [ion binding]; metal-binding site 663278006379 dimer interface [polypeptide binding]; other site 663278006380 structural Zn2+ binding site [ion binding]; other site 663278006381 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 663278006382 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 663278006383 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 663278006384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 663278006385 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 663278006386 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 663278006387 protein binding site [polypeptide binding]; other site 663278006388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 663278006389 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 663278006390 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 663278006391 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 663278006392 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 663278006393 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 663278006394 active site 663278006395 catalytic tetrad [active] 663278006396 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 663278006397 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 663278006398 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 663278006399 active site 663278006400 NTP binding site [chemical binding]; other site 663278006401 metal binding triad [ion binding]; metal-binding site 663278006402 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 663278006403 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 663278006404 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 663278006405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278006406 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 663278006407 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 663278006408 active site 663278006409 tetramer interface; other site 663278006410 peptide chain release factor 2; Validated; Region: prfB; PRK00578 663278006411 This domain is found in peptide chain release factors; Region: PCRF; smart00937 663278006412 RF-1 domain; Region: RF-1; pfam00472 663278006413 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 663278006414 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 663278006415 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 663278006416 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 663278006417 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278006418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278006419 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278006420 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 663278006421 Walker A/P-loop; other site 663278006422 ATP binding site [chemical binding]; other site 663278006423 Q-loop/lid; other site 663278006424 ABC transporter signature motif; other site 663278006425 Walker B; other site 663278006426 D-loop; other site 663278006427 H-loop/switch region; other site 663278006428 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278006429 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278006430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278006431 Walker A/P-loop; other site 663278006432 ATP binding site [chemical binding]; other site 663278006433 Q-loop/lid; other site 663278006434 ABC transporter signature motif; other site 663278006435 Walker B; other site 663278006436 D-loop; other site 663278006437 H-loop/switch region; other site 663278006438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278006439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278006440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278006441 dimerization interface [polypeptide binding]; other site 663278006442 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 663278006443 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 663278006444 AsnC family; Region: AsnC_trans_reg; pfam01037 663278006445 hypothetical protein; Validated; Region: PRK07682 663278006446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278006447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278006448 homodimer interface [polypeptide binding]; other site 663278006449 catalytic residue [active] 663278006450 Uncharacterized conserved protein [Function unknown]; Region: COG2006 663278006451 Domain of unknown function (DUF362); Region: DUF362; pfam04015 663278006452 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 663278006453 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 663278006454 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 663278006455 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 663278006456 Methyltransferase domain; Region: Methyltransf_31; pfam13847 663278006457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278006458 S-adenosylmethionine binding site [chemical binding]; other site 663278006459 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 663278006460 SmpB-tmRNA interface; other site 663278006461 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 663278006462 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 663278006463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278006464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278006465 non-specific DNA binding site [nucleotide binding]; other site 663278006466 salt bridge; other site 663278006467 sequence-specific DNA binding site [nucleotide binding]; other site 663278006468 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 663278006469 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 663278006470 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 663278006471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278006472 DNA-binding site [nucleotide binding]; DNA binding site 663278006473 UTRA domain; Region: UTRA; pfam07702 663278006474 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 663278006475 intersubunit interface [polypeptide binding]; other site 663278006476 Radical SAM superfamily; Region: Radical_SAM; pfam04055 663278006477 active site 663278006478 catalytic residue [active] 663278006479 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 663278006480 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 663278006481 tetramer interface [polypeptide binding]; other site 663278006482 catalytic Zn binding site [ion binding]; other site 663278006483 NADP binding site [chemical binding]; other site 663278006484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278006485 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 663278006486 DNA-binding site [nucleotide binding]; DNA binding site 663278006487 UTRA domain; Region: UTRA; pfam07702 663278006488 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 663278006489 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 663278006490 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 663278006491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278006492 ABC-ATPase subunit interface; other site 663278006493 putative PBP binding loops; other site 663278006494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278006495 dimer interface [polypeptide binding]; other site 663278006496 conserved gate region; other site 663278006497 putative PBP binding loops; other site 663278006498 ABC-ATPase subunit interface; other site 663278006499 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 663278006500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278006501 Walker A/P-loop; other site 663278006502 ATP binding site [chemical binding]; other site 663278006503 Q-loop/lid; other site 663278006504 ABC transporter signature motif; other site 663278006505 Walker B; other site 663278006506 D-loop; other site 663278006507 H-loop/switch region; other site 663278006508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 663278006509 Predicted transcriptional regulators [Transcription]; Region: COG1695 663278006510 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 663278006511 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 663278006512 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 663278006513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 663278006514 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 663278006515 YibE/F-like protein; Region: YibE_F; cl02259 663278006516 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278006517 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278006518 active site 663278006519 metal binding site [ion binding]; metal-binding site 663278006520 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 663278006521 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 663278006522 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 663278006523 putative ligand binding site [chemical binding]; other site 663278006524 Probable zinc-binding domain; Region: zf-trcl; pfam13451 663278006525 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 663278006526 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 663278006527 Probable zinc-binding domain; Region: zf-trcl; pfam13451 663278006528 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 663278006529 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 663278006530 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 663278006531 FMN binding site [chemical binding]; other site 663278006532 substrate binding site [chemical binding]; other site 663278006533 putative catalytic residue [active] 663278006534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278006535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278006536 non-specific DNA binding site [nucleotide binding]; other site 663278006537 salt bridge; other site 663278006538 sequence-specific DNA binding site [nucleotide binding]; other site 663278006539 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 663278006540 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 663278006541 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278006542 active site 663278006543 metal binding site [ion binding]; metal-binding site 663278006544 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 663278006545 YibE/F-like protein; Region: YibE_F; pfam07907 663278006546 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 663278006547 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 663278006548 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 663278006549 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 663278006550 RNA binding site [nucleotide binding]; other site 663278006551 Membrane transport protein; Region: Mem_trans; cl09117 663278006552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278006553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278006554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 663278006555 dimerization interface [polypeptide binding]; other site 663278006556 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 663278006557 dimer interface [polypeptide binding]; other site 663278006558 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 663278006559 active site 663278006560 metal binding site [ion binding]; metal-binding site 663278006561 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 663278006562 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 663278006563 metal binding site [ion binding]; metal-binding site 663278006564 putative dimer interface [polypeptide binding]; other site 663278006565 Transcriptional regulators [Transcription]; Region: FadR; COG2186 663278006566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 663278006567 DNA-binding site [nucleotide binding]; DNA binding site 663278006568 FCD domain; Region: FCD; pfam07729 663278006569 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 663278006570 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 663278006571 tetramer interface [polypeptide binding]; other site 663278006572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278006573 catalytic residue [active] 663278006574 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 663278006575 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 663278006576 Walker A/P-loop; other site 663278006577 ATP binding site [chemical binding]; other site 663278006578 Q-loop/lid; other site 663278006579 ABC transporter signature motif; other site 663278006580 Walker B; other site 663278006581 D-loop; other site 663278006582 H-loop/switch region; other site 663278006583 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 663278006584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278006585 dimer interface [polypeptide binding]; other site 663278006586 conserved gate region; other site 663278006587 putative PBP binding loops; other site 663278006588 ABC-ATPase subunit interface; other site 663278006589 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 663278006590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 663278006591 substrate binding pocket [chemical binding]; other site 663278006592 membrane-bound complex binding site; other site 663278006593 hinge residues; other site 663278006594 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 663278006595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278006596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278006597 homodimer interface [polypeptide binding]; other site 663278006598 catalytic residue [active] 663278006599 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 663278006600 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 663278006601 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 663278006602 Amidinotransferase; Region: Amidinotransf; cl12043 663278006603 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 663278006604 Amidinotransferase; Region: Amidinotransf; pfam02274 663278006605 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 663278006606 putative metal binding site [ion binding]; other site 663278006607 putative dimer interface [polypeptide binding]; other site 663278006608 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 663278006609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 663278006610 inhibitor-cofactor binding pocket; inhibition site 663278006611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278006612 catalytic residue [active] 663278006613 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 663278006614 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 663278006615 NAD binding site [chemical binding]; other site 663278006616 FMN-binding domain; Region: FMN_bind; cl01081 663278006617 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 663278006618 ApbE family; Region: ApbE; pfam02424 663278006619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278006620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278006621 WHG domain; Region: WHG; pfam13305 663278006622 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 663278006623 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 663278006624 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 663278006625 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 663278006626 dimerization interface [polypeptide binding]; other site 663278006627 active site 663278006628 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 663278006629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278006630 DNA binding residues [nucleotide binding] 663278006631 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 663278006632 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 663278006633 Small acid-soluble spore protein H family; Region: SspH; pfam08141 663278006634 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 663278006635 active site 663278006636 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 663278006637 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 663278006638 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 663278006639 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 663278006640 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 663278006641 metal ion-dependent adhesion site (MIDAS); other site 663278006642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278006643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 663278006644 putative substrate translocation pore; other site 663278006645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278006646 dimerization interface [polypeptide binding]; other site 663278006647 putative DNA binding site [nucleotide binding]; other site 663278006648 putative Zn2+ binding site [ion binding]; other site 663278006649 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 663278006650 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 663278006651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 663278006652 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 663278006653 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 663278006654 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 663278006655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 663278006656 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 663278006657 ribonuclease R; Region: RNase_R; TIGR02063 663278006658 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 663278006659 RNB domain; Region: RNB; pfam00773 663278006660 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 663278006661 RNA binding site [nucleotide binding]; other site 663278006662 Preprotein translocase SecG subunit; Region: SecG; pfam03840 663278006663 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 663278006664 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 663278006665 CAP-like domain; other site 663278006666 active site 663278006667 primary dimer interface [polypeptide binding]; other site 663278006668 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 663278006669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 663278006670 Mg2+ binding site [ion binding]; other site 663278006671 G-X-G motif; other site 663278006672 DNA gyrase B; Region: DNA_gyraseB; pfam00204 663278006673 ATP binding site [chemical binding]; other site 663278006674 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 663278006675 active site 663278006676 putative metal-binding site [ion binding]; other site 663278006677 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 663278006678 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 663278006679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278006680 Walker A motif; other site 663278006681 ATP binding site [chemical binding]; other site 663278006682 Walker B motif; other site 663278006683 arginine finger; other site 663278006684 Peptidase family M41; Region: Peptidase_M41; pfam01434 663278006685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278006686 active site 663278006687 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 663278006688 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 663278006689 Ligand Binding Site [chemical binding]; other site 663278006690 TilS substrate C-terminal domain; Region: TilS_C; smart00977 663278006691 replicative DNA helicase; Region: DnaB; TIGR00665 663278006692 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 663278006693 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 663278006694 Walker A motif; other site 663278006695 ATP binding site [chemical binding]; other site 663278006696 Walker B motif; other site 663278006697 DNA binding loops [nucleotide binding] 663278006698 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 663278006699 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 663278006700 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 663278006701 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 663278006702 DHH family; Region: DHH; pfam01368 663278006703 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 663278006704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 663278006705 YcjX-like family, DUF463; Region: DUF463; cl01193 663278006706 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 663278006707 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 663278006708 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 663278006709 active site 663278006710 Substrate binding site; other site 663278006711 Mg++ binding site; other site 663278006712 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 663278006713 putative trimer interface [polypeptide binding]; other site 663278006714 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 663278006715 putative CoA binding site [chemical binding]; other site 663278006716 putative trimer interface [polypeptide binding]; other site 663278006717 putative CoA binding site [chemical binding]; other site 663278006718 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 663278006719 active site 663278006720 substrate binding site [chemical binding]; other site 663278006721 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 663278006722 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 663278006723 RNA/DNA hybrid binding site [nucleotide binding]; other site 663278006724 active site 663278006725 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 663278006726 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 663278006727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278006728 catalytic residue [active] 663278006729 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 663278006730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 663278006731 catalytic loop [active] 663278006732 iron binding site [ion binding]; other site 663278006733 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 663278006734 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 663278006735 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 663278006736 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 663278006737 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 663278006738 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 663278006739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 663278006740 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 663278006741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278006742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278006743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278006744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 663278006745 putative substrate translocation pore; other site 663278006746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278006747 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 663278006748 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 663278006749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 663278006750 active site 663278006751 metal binding site [ion binding]; metal-binding site 663278006752 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 663278006753 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 663278006754 active site 663278006755 catalytic residues [active] 663278006756 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 663278006757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 663278006758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 663278006759 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 663278006760 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 663278006761 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 663278006762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 663278006763 ATP binding site [chemical binding]; other site 663278006764 Mg2+ binding site [ion binding]; other site 663278006765 G-X-G motif; other site 663278006766 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 663278006767 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 663278006768 ABC-ATPase subunit interface; other site 663278006769 dimer interface [polypeptide binding]; other site 663278006770 putative PBP binding regions; other site 663278006771 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 663278006772 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 663278006773 intersubunit interface [polypeptide binding]; other site 663278006774 nitrogenase iron protein; Region: nifH; TIGR01287 663278006775 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 663278006776 Nucleotide-binding sites [chemical binding]; other site 663278006777 Walker A motif; other site 663278006778 Switch I region of nucleotide binding site; other site 663278006779 Fe4S4 binding sites [ion binding]; other site 663278006780 Switch II region of nucleotide binding site; other site 663278006781 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 663278006782 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278006783 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 663278006784 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278006785 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 663278006786 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 663278006787 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910 663278006788 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278006789 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 663278006790 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 663278006791 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278006792 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 663278006793 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 663278006794 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 663278006795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278006796 FeS/SAM binding site; other site 663278006797 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 663278006798 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 663278006799 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 663278006800 metal binding site [ion binding]; metal-binding site 663278006801 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 663278006802 active site 663278006803 catalytic residues [active] 663278006804 metal binding site [ion binding]; metal-binding site 663278006805 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 663278006806 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 663278006807 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 663278006808 putative ligand binding residues [chemical binding]; other site 663278006809 Fn3 associated; Region: Fn3_assoc; pfam13287 663278006810 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 663278006811 generic binding surface II; other site 663278006812 generic binding surface I; other site 663278006813 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 663278006814 generic binding surface II; other site 663278006815 generic binding surface I; other site 663278006816 Fn3 associated; Region: Fn3_assoc; pfam13287 663278006817 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 663278006818 active site 663278006819 YibE/F-like protein; Region: YibE_F; pfam07907 663278006820 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 663278006821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278006822 ATP binding site [chemical binding]; other site 663278006823 Mg2+ binding site [ion binding]; other site 663278006824 G-X-G motif; other site 663278006825 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 663278006826 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 663278006827 ligand binding site [chemical binding]; other site 663278006828 Response regulator receiver domain; Region: Response_reg; pfam00072 663278006829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278006830 active site 663278006831 phosphorylation site [posttranslational modification] 663278006832 intermolecular recognition site; other site 663278006833 dimerization interface [polypeptide binding]; other site 663278006834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 663278006835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278006836 Predicted amidohydrolase [General function prediction only]; Region: COG0388 663278006837 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 663278006838 active site 663278006839 catalytic triad [active] 663278006840 dimer interface [polypeptide binding]; other site 663278006841 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 663278006842 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 663278006843 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 663278006844 Walker A/P-loop; other site 663278006845 ATP binding site [chemical binding]; other site 663278006846 Q-loop/lid; other site 663278006847 ABC transporter signature motif; other site 663278006848 Walker B; other site 663278006849 D-loop; other site 663278006850 H-loop/switch region; other site 663278006851 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 663278006852 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 663278006853 Walker A/P-loop; other site 663278006854 ATP binding site [chemical binding]; other site 663278006855 Q-loop/lid; other site 663278006856 ABC transporter signature motif; other site 663278006857 Walker B; other site 663278006858 D-loop; other site 663278006859 H-loop/switch region; other site 663278006860 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 663278006861 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 663278006862 TM-ABC transporter signature motif; other site 663278006863 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 663278006864 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 663278006865 TM-ABC transporter signature motif; other site 663278006866 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 663278006867 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 663278006868 ligand binding site [chemical binding]; other site 663278006869 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278006870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278006871 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278006872 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278006873 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278006874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278006875 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278006876 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 663278006877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 663278006878 active site 663278006879 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 663278006880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278006881 active site 663278006882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278006883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278006884 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 663278006885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278006886 active site 663278006887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278006888 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 663278006889 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 663278006890 putative trimer interface [polypeptide binding]; other site 663278006891 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 663278006892 trimer interface [polypeptide binding]; other site 663278006893 active site 663278006894 substrate binding site [chemical binding]; other site 663278006895 putative CoA binding site [chemical binding]; other site 663278006896 CoA binding site [chemical binding]; other site 663278006897 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 663278006898 putative glycosyl transferase; Provisional; Region: PRK10307 663278006899 Acyltransferase family; Region: Acyl_transf_3; pfam01757 663278006900 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 663278006901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278006902 active site 663278006903 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 663278006904 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 663278006905 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 663278006906 NADP binding site [chemical binding]; other site 663278006907 active site 663278006908 putative substrate binding site [chemical binding]; other site 663278006909 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 663278006910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278006911 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 663278006912 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 663278006913 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 663278006914 NADP-binding site; other site 663278006915 homotetramer interface [polypeptide binding]; other site 663278006916 substrate binding site [chemical binding]; other site 663278006917 homodimer interface [polypeptide binding]; other site 663278006918 active site 663278006919 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 663278006920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 663278006921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278006922 dimer interface [polypeptide binding]; other site 663278006923 conserved gate region; other site 663278006924 ABC-ATPase subunit interface; other site 663278006925 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 663278006926 dimer interface [polypeptide binding]; other site 663278006927 ABC-ATPase subunit interface; other site 663278006928 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 663278006929 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 663278006930 Walker A/P-loop; other site 663278006931 ATP binding site [chemical binding]; other site 663278006932 Q-loop/lid; other site 663278006933 ABC transporter signature motif; other site 663278006934 Walker B; other site 663278006935 D-loop; other site 663278006936 H-loop/switch region; other site 663278006937 FOG: CBS domain [General function prediction only]; Region: COG0517 663278006938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 663278006939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 663278006940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 663278006941 dimerization interface [polypeptide binding]; other site 663278006942 DNA binding residues [nucleotide binding] 663278006943 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 663278006944 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 663278006945 dimanganese center [ion binding]; other site 663278006946 CotJB protein; Region: CotJB; pfam12652 663278006947 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 663278006948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278006949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278006950 non-specific DNA binding site [nucleotide binding]; other site 663278006951 salt bridge; other site 663278006952 sequence-specific DNA binding site [nucleotide binding]; other site 663278006953 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 663278006954 Mor transcription activator family; Region: Mor; cl02360 663278006955 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 663278006956 Clp amino terminal domain; Region: Clp_N; pfam02861 663278006957 Clp amino terminal domain; Region: Clp_N; pfam02861 663278006958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278006959 Walker A motif; other site 663278006960 ATP binding site [chemical binding]; other site 663278006961 Walker B motif; other site 663278006962 arginine finger; other site 663278006963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278006964 Walker A motif; other site 663278006965 ATP binding site [chemical binding]; other site 663278006966 Walker B motif; other site 663278006967 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 663278006968 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 663278006969 active site 663278006970 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 663278006971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278006972 active site 663278006973 phosphorylation site [posttranslational modification] 663278006974 intermolecular recognition site; other site 663278006975 dimerization interface [polypeptide binding]; other site 663278006976 LytTr DNA-binding domain; Region: LytTR; smart00850 663278006977 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 663278006978 Quinolinate synthetase A protein; Region: NadA; pfam02445 663278006979 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 663278006980 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 663278006981 Ligand Binding Site [chemical binding]; other site 663278006982 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 663278006983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278006984 FeS/SAM binding site; other site 663278006985 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 663278006986 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 663278006987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 663278006988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278006989 non-specific DNA binding site [nucleotide binding]; other site 663278006990 salt bridge; other site 663278006991 sequence-specific DNA binding site [nucleotide binding]; other site 663278006992 Mor transcription activator family; Region: Mor; cl02360 663278006993 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 663278006994 active site 663278006995 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 663278006996 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 663278006997 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 663278006998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 663278006999 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 663278007000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278007001 dimer interface [polypeptide binding]; other site 663278007002 conserved gate region; other site 663278007003 putative PBP binding loops; other site 663278007004 ABC-ATPase subunit interface; other site 663278007005 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 663278007006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278007007 dimer interface [polypeptide binding]; other site 663278007008 conserved gate region; other site 663278007009 putative PBP binding loops; other site 663278007010 ABC-ATPase subunit interface; other site 663278007011 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 663278007012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278007013 Walker A/P-loop; other site 663278007014 ATP binding site [chemical binding]; other site 663278007015 Q-loop/lid; other site 663278007016 ABC transporter signature motif; other site 663278007017 Walker B; other site 663278007018 D-loop; other site 663278007019 H-loop/switch region; other site 663278007020 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 663278007021 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 663278007022 DNA binding residues [nucleotide binding] 663278007023 drug binding residues [chemical binding]; other site 663278007024 dimer interface [polypeptide binding]; other site 663278007025 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 663278007026 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 663278007027 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278007028 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 663278007029 Nitrogen regulatory protein P-II; Region: P-II; smart00938 663278007030 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 663278007031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 663278007032 substrate binding pocket [chemical binding]; other site 663278007033 membrane-bound complex binding site; other site 663278007034 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 663278007035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 663278007036 dimer interface [polypeptide binding]; other site 663278007037 conserved gate region; other site 663278007038 putative PBP binding loops; other site 663278007039 ABC-ATPase subunit interface; other site 663278007040 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 663278007041 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 663278007042 Walker A/P-loop; other site 663278007043 ATP binding site [chemical binding]; other site 663278007044 Q-loop/lid; other site 663278007045 ABC transporter signature motif; other site 663278007046 Walker B; other site 663278007047 D-loop; other site 663278007048 H-loop/switch region; other site 663278007049 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 663278007050 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 663278007051 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 663278007052 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 663278007053 urea carboxylase; Region: urea_carbox; TIGR02712 663278007054 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 663278007055 ATP-grasp domain; Region: ATP-grasp_4; cl17255 663278007056 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 663278007057 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 663278007058 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 663278007059 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 663278007060 carboxyltransferase (CT) interaction site; other site 663278007061 biotinylation site [posttranslational modification]; other site 663278007062 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 663278007063 Amidase; Region: Amidase; cl11426 663278007064 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 663278007065 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 663278007066 Ligand binding site; other site 663278007067 Putative Catalytic site; other site 663278007068 DXD motif; other site 663278007069 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 663278007070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 663278007071 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 663278007072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278007073 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 663278007074 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 663278007075 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 663278007076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 663278007077 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 663278007078 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 663278007079 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 663278007080 DNA binding site [nucleotide binding] 663278007081 transcriptional repressor DicA; Reviewed; Region: PRK09706 663278007082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 663278007083 non-specific DNA binding site [nucleotide binding]; other site 663278007084 salt bridge; other site 663278007085 sequence-specific DNA binding site [nucleotide binding]; other site 663278007086 Helix-turn-helix domain; Region: HTH_17; pfam12728 663278007087 Transcription termination factor nusG; Region: NusG; pfam02357 663278007088 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 663278007089 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 663278007090 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 663278007091 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 663278007092 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 663278007093 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 663278007094 dimer interface [polypeptide binding]; other site 663278007095 ssDNA binding site [nucleotide binding]; other site 663278007096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 663278007097 HNH endonuclease; Region: HNH_3; pfam13392 663278007098 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 663278007099 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278007100 P-loop; other site 663278007101 Magnesium ion binding site [ion binding]; other site 663278007102 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278007103 Magnesium ion binding site [ion binding]; other site 663278007104 ParB-like nuclease domain; Region: ParB; smart00470 663278007105 SpoVG; Region: SpoVG; cl00915 663278007106 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 663278007107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 663278007108 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 663278007109 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278007110 Walker A motif; other site 663278007111 ATP binding site [chemical binding]; other site 663278007112 Walker B motif; other site 663278007113 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 663278007114 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 663278007115 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 663278007116 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 663278007117 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 663278007118 Uncharacterized conserved protein [Function unknown]; Region: COG4933 663278007119 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 663278007120 Toprim-like; Region: Toprim_2; pfam13155 663278007121 AAA-like domain; Region: AAA_10; pfam12846 663278007122 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 663278007123 catalytic residue [active] 663278007124 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 663278007125 Sel1-like repeats; Region: SEL1; smart00671 663278007126 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 663278007127 Sel1-like repeats; Region: SEL1; smart00671 663278007128 Sel1-like repeats; Region: SEL1; smart00671 663278007129 Sel1-like repeats; Region: SEL1; smart00671 663278007130 Sel1-like repeats; Region: SEL1; smart00671 663278007131 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 663278007132 Sel1-like repeats; Region: SEL1; smart00671 663278007133 Sel1-like repeats; Region: SEL1; smart00671 663278007134 Sel1-like repeats; Region: SEL1; smart00671 663278007135 Sel1-like repeats; Region: SEL1; smart00671 663278007136 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 663278007137 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 663278007138 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 663278007139 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 663278007140 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 663278007141 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 663278007142 Walker A motif; other site 663278007143 ATP binding site [chemical binding]; other site 663278007144 Walker B motif; other site 663278007145 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 663278007146 PLD-like domain; Region: PLDc_2; pfam13091 663278007147 putative active site [active] 663278007148 catalytic site [active] 663278007149 S-adenosylmethionine synthetase; Validated; Region: PRK05250 663278007150 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 663278007151 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 663278007152 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 663278007153 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 663278007154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278007155 FeS/SAM binding site; other site 663278007156 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 663278007157 ATP cone domain; Region: ATP-cone; pfam03477 663278007158 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 663278007159 Class III ribonucleotide reductase; Region: RNR_III; cd01675 663278007160 active site 663278007161 Zn binding site [ion binding]; other site 663278007162 glycine loop; other site 663278007163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 663278007164 active site 663278007165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278007166 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278007167 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 663278007168 Walker A/P-loop; other site 663278007169 ATP binding site [chemical binding]; other site 663278007170 Q-loop/lid; other site 663278007171 ABC transporter signature motif; other site 663278007172 Walker B; other site 663278007173 D-loop; other site 663278007174 H-loop/switch region; other site 663278007175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 663278007176 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 663278007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278007178 Walker A/P-loop; other site 663278007179 ATP binding site [chemical binding]; other site 663278007180 Q-loop/lid; other site 663278007181 ABC transporter signature motif; other site 663278007182 Walker B; other site 663278007183 D-loop; other site 663278007184 H-loop/switch region; other site 663278007185 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 663278007186 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 663278007187 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 663278007188 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 663278007189 NodB motif; other site 663278007190 active site 663278007191 catalytic site [active] 663278007192 Zn binding site [ion binding]; other site 663278007193 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 663278007194 DNA polymerase IV; Validated; Region: PRK01810 663278007195 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 663278007196 active site 663278007197 DNA binding site [nucleotide binding] 663278007198 CAAX protease self-immunity; Region: Abi; pfam02517 663278007199 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 663278007200 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 663278007201 minor groove reading motif; other site 663278007202 helix-hairpin-helix signature motif; other site 663278007203 substrate binding pocket [chemical binding]; other site 663278007204 active site 663278007205 SpoVG; Region: SpoVG; cl00915 663278007206 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 663278007207 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 663278007208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 663278007209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 663278007210 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 663278007211 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 663278007212 putative ATP binding site [chemical binding]; other site 663278007213 putative substrate interface [chemical binding]; other site 663278007214 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 663278007215 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 663278007216 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 663278007217 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 663278007218 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 663278007219 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 663278007220 iron-sulfur cluster [ion binding]; other site 663278007221 [2Fe-2S] cluster binding site [ion binding]; other site 663278007222 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278007223 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 663278007224 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 663278007225 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 663278007226 dimer interface [polypeptide binding]; other site 663278007227 ssDNA binding site [nucleotide binding]; other site 663278007228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 663278007229 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 663278007230 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 663278007231 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 663278007232 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 663278007233 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 663278007234 inhibitor-cofactor binding pocket; inhibition site 663278007235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278007236 catalytic residue [active] 663278007237 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 663278007238 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 663278007239 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 663278007240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 663278007241 active site 663278007242 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 663278007243 active site 663278007244 catalytic triad [active] 663278007245 oxyanion hole [active] 663278007246 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 663278007247 peptidase T; Region: peptidase-T; TIGR01882 663278007248 metal binding site [ion binding]; metal-binding site 663278007249 dimer interface [polypeptide binding]; other site 663278007250 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 663278007251 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 663278007252 Ligand binding site; other site 663278007253 Putative Catalytic site; other site 663278007254 DXD motif; other site 663278007255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 663278007256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278007257 active site 663278007258 phosphorylation site [posttranslational modification] 663278007259 intermolecular recognition site; other site 663278007260 dimerization interface [polypeptide binding]; other site 663278007261 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 663278007262 DNA binding site [nucleotide binding] 663278007263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 663278007264 dimerization interface [polypeptide binding]; other site 663278007265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 663278007266 dimer interface [polypeptide binding]; other site 663278007267 phosphorylation site [posttranslational modification] 663278007268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278007269 ATP binding site [chemical binding]; other site 663278007270 Mg2+ binding site [ion binding]; other site 663278007271 G-X-G motif; other site 663278007272 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 663278007273 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 663278007274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 663278007275 Walker A motif; other site 663278007276 ATP binding site [chemical binding]; other site 663278007277 Walker B motif; other site 663278007278 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 663278007279 Clp protease; Region: CLP_protease; pfam00574 663278007280 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 663278007281 oligomer interface [polypeptide binding]; other site 663278007282 active site residues [active] 663278007283 trigger factor; Provisional; Region: tig; PRK01490 663278007284 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 663278007285 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 663278007286 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 663278007287 Spore germination protein; Region: Spore_permease; cl17796 663278007288 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 663278007289 glycyl-tRNA synthetase; Provisional; Region: PRK04173 663278007290 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 663278007291 motif 1; other site 663278007292 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 663278007293 active site 663278007294 motif 2; other site 663278007295 motif 3; other site 663278007296 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 663278007297 anticodon binding site; other site 663278007298 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 663278007299 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 663278007300 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 663278007301 ligand binding site [chemical binding]; other site 663278007302 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 663278007303 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 663278007304 Flagellar protein FliS; Region: FliS; cl00654 663278007305 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 663278007306 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 663278007307 FlaG protein; Region: FlaG; pfam03646 663278007308 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 663278007309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278007310 active site 663278007311 phosphorylation site [posttranslational modification] 663278007312 intermolecular recognition site; other site 663278007313 dimerization interface [polypeptide binding]; other site 663278007314 CheB methylesterase; Region: CheB_methylest; pfam01339 663278007315 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 663278007316 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 663278007317 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 663278007318 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 663278007319 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 663278007320 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 663278007321 putative binding surface; other site 663278007322 active site 663278007323 P2 response regulator binding domain; Region: P2; pfam07194 663278007324 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 663278007325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278007326 ATP binding site [chemical binding]; other site 663278007327 Mg2+ binding site [ion binding]; other site 663278007328 G-X-G motif; other site 663278007329 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 663278007330 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 663278007331 putative metal binding site; other site 663278007332 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 663278007333 flagellin; Reviewed; Region: PRK08869 663278007334 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 663278007335 Global regulator protein family; Region: CsrA; pfam02599 663278007336 FliW protein; Region: FliW; cl00740 663278007337 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 663278007338 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 663278007339 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 663278007340 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 663278007341 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 663278007342 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 663278007343 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 663278007344 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 663278007345 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 663278007346 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 663278007347 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 663278007348 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 663278007349 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 663278007350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278007351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278007352 DNA binding residues [nucleotide binding] 663278007353 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 663278007354 FHIPEP family; Region: FHIPEP; pfam00771 663278007355 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 663278007356 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 663278007357 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 663278007358 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 663278007359 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 663278007360 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 663278007361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278007362 Response regulator receiver domain; Region: Response_reg; pfam00072 663278007363 active site 663278007364 phosphorylation site [posttranslational modification] 663278007365 intermolecular recognition site; other site 663278007366 dimerization interface [polypeptide binding]; other site 663278007367 flagellar motor switch protein; Validated; Region: PRK08119 663278007368 CheC-like family; Region: CheC; pfam04509 663278007369 CheC-like family; Region: CheC; pfam04509 663278007370 flagellar motor switch protein FliN; Region: fliN; TIGR02480 663278007371 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 663278007372 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 663278007373 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 663278007374 Flagellar protein (FlbD); Region: FlbD; pfam06289 663278007375 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 663278007376 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 663278007377 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 663278007378 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 663278007379 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 663278007380 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 663278007381 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 663278007382 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 663278007383 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 663278007384 Walker A motif/ATP binding site; other site 663278007385 Walker B motif; other site 663278007386 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 663278007387 FliG C-terminal domain; Region: FliG_C; pfam01706 663278007388 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 663278007389 FliG C-terminal domain; Region: FliG_C; pfam01706 663278007390 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 663278007391 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 663278007392 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 663278007393 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 663278007394 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 663278007395 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 663278007396 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 663278007397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 663278007398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 663278007399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 663278007400 dimerization interface [polypeptide binding]; other site 663278007401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278007402 putative substrate translocation pore; other site 663278007403 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 663278007404 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 663278007405 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 663278007406 Spore germination protein; Region: Spore_permease; cl17796 663278007407 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 663278007408 homodimer interface [polypeptide binding]; other site 663278007409 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 663278007410 active site pocket [active] 663278007411 4-alpha-glucanotransferase; Provisional; Region: PRK14508 663278007412 Transcriptional regulators [Transcription]; Region: PurR; COG1609 663278007413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 663278007414 DNA binding site [nucleotide binding] 663278007415 domain linker motif; other site 663278007416 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 663278007417 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 663278007418 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 663278007419 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 663278007420 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 663278007421 Walker A/P-loop; other site 663278007422 ATP binding site [chemical binding]; other site 663278007423 Q-loop/lid; other site 663278007424 ABC transporter signature motif; other site 663278007425 Walker B; other site 663278007426 D-loop; other site 663278007427 H-loop/switch region; other site 663278007428 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 663278007429 Walker A/P-loop; other site 663278007430 ATP binding site [chemical binding]; other site 663278007431 Q-loop/lid; other site 663278007432 ABC transporter signature motif; other site 663278007433 Walker B; other site 663278007434 D-loop; other site 663278007435 H-loop/switch region; other site 663278007436 Cobalt transport protein; Region: CbiQ; cl00463 663278007437 Ubiquitin-like proteins; Region: UBQ; cl00155 663278007438 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 663278007439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 663278007440 FeS/SAM binding site; other site 663278007441 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 663278007442 active site 663278007443 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 663278007444 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 663278007445 HIGH motif; other site 663278007446 active site 663278007447 KMSKS motif; other site 663278007448 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 663278007449 tRNA binding surface [nucleotide binding]; other site 663278007450 anticodon binding site; other site 663278007451 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 663278007452 dimer interface [polypeptide binding]; other site 663278007453 putative tRNA-binding site [nucleotide binding]; other site 663278007454 Domain of unknown function (DUF348); Region: DUF348; pfam03990 663278007455 G5 domain; Region: G5; pfam07501 663278007456 3D domain; Region: 3D; cl01439 663278007457 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 663278007458 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 663278007459 23S rRNA interface [nucleotide binding]; other site 663278007460 L3 interface [polypeptide binding]; other site 663278007461 Transcriptional regulator [Transcription]; Region: LytR; COG1316 663278007462 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 663278007463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 663278007464 ATP binding site [chemical binding]; other site 663278007465 Mg2+ binding site [ion binding]; other site 663278007466 G-X-G motif; other site 663278007467 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 663278007468 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 663278007469 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 663278007470 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 663278007471 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278007472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278007473 DNA binding residues [nucleotide binding] 663278007474 Protein of unknown function (DUF975); Region: DUF975; cl10504 663278007475 2-isopropylmalate synthase; Validated; Region: PRK03739 663278007476 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 663278007477 active site 663278007478 catalytic residues [active] 663278007479 metal binding site [ion binding]; metal-binding site 663278007480 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 663278007481 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 663278007482 active site 663278007483 metal binding site [ion binding]; metal-binding site 663278007484 alanine racemase; Reviewed; Region: alr; PRK00053 663278007485 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 663278007486 active site 663278007487 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 663278007488 dimer interface [polypeptide binding]; other site 663278007489 substrate binding site [chemical binding]; other site 663278007490 catalytic residues [active] 663278007491 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 663278007492 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 663278007493 RNA methyltransferase, RsmE family; Region: TIGR00046 663278007494 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 663278007495 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 663278007496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278007497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 663278007498 catalytic loop [active] 663278007499 iron binding site [ion binding]; other site 663278007500 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 663278007501 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 663278007502 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 663278007503 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 663278007504 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 663278007505 dimer interface [polypeptide binding]; other site 663278007506 [2Fe-2S] cluster binding site [ion binding]; other site 663278007507 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 663278007508 SLBB domain; Region: SLBB; pfam10531 663278007509 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 663278007510 4Fe-4S binding domain; Region: Fer4; pfam00037 663278007511 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 663278007512 4Fe-4S binding domain; Region: Fer4_6; pfam12837 663278007513 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 663278007514 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 663278007515 putative dimer interface [polypeptide binding]; other site 663278007516 [2Fe-2S] cluster binding site [ion binding]; other site 663278007517 Uncharacterized conserved protein [Function unknown]; Region: COG1751 663278007518 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 663278007519 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 663278007520 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 663278007521 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 663278007522 B12 binding site [chemical binding]; other site 663278007523 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 663278007524 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 663278007525 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 663278007526 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 663278007527 ApbE family; Region: ApbE; pfam02424 663278007528 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 663278007529 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 663278007530 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 663278007531 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 663278007532 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 663278007533 Walker A/P-loop; other site 663278007534 ATP binding site [chemical binding]; other site 663278007535 Q-loop/lid; other site 663278007536 ABC transporter signature motif; other site 663278007537 Walker B; other site 663278007538 D-loop; other site 663278007539 H-loop/switch region; other site 663278007540 FeS assembly protein SufB; Region: sufB; TIGR01980 663278007541 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 663278007542 FeS assembly protein SufD; Region: sufD; TIGR01981 663278007543 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 663278007544 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 663278007545 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 663278007546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 663278007547 catalytic residue [active] 663278007548 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 663278007549 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 663278007550 trimerization site [polypeptide binding]; other site 663278007551 active site 663278007552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 663278007553 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 663278007554 active site 663278007555 metal binding site [ion binding]; metal-binding site 663278007556 drug efflux system protein MdtG; Provisional; Region: PRK09874 663278007557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 663278007558 putative substrate translocation pore; other site 663278007559 PilZ domain; Region: PilZ; pfam07238 663278007560 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 663278007561 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 663278007562 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 663278007563 minor groove reading motif; other site 663278007564 helix-hairpin-helix signature motif; other site 663278007565 substrate binding pocket [chemical binding]; other site 663278007566 active site 663278007567 DNA polymerase I; Provisional; Region: PRK05755 663278007568 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 663278007569 active site 663278007570 metal binding site 1 [ion binding]; metal-binding site 663278007571 putative 5' ssDNA interaction site; other site 663278007572 metal binding site 3; metal-binding site 663278007573 metal binding site 2 [ion binding]; metal-binding site 663278007574 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 663278007575 putative DNA binding site [nucleotide binding]; other site 663278007576 putative metal binding site [ion binding]; other site 663278007577 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 663278007578 active site 663278007579 substrate binding site [chemical binding]; other site 663278007580 catalytic site [active] 663278007581 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 663278007582 active site 663278007583 DNA binding site [nucleotide binding] 663278007584 catalytic site [active] 663278007585 Low molecular weight phosphatase family; Region: LMWPc; cd00115 663278007586 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 663278007587 active site 663278007588 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 663278007589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278007590 Coenzyme A binding pocket [chemical binding]; other site 663278007591 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 663278007592 UGMP family protein; Validated; Region: PRK09604 663278007593 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 663278007594 Germination protease; Region: Peptidase_A25; cl04057 663278007595 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 663278007596 acyl carrier protein; Provisional; Region: acpP; PRK00982 663278007597 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 663278007598 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 663278007599 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 663278007600 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 663278007601 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 663278007602 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 663278007603 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 663278007604 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 663278007605 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 663278007606 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 663278007607 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 663278007608 carboxyltransferase (CT) interaction site; other site 663278007609 biotinylation site [posttranslational modification]; other site 663278007610 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 663278007611 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 663278007612 dimer interface [polypeptide binding]; other site 663278007613 active site 663278007614 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 663278007615 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 663278007616 NAD(P) binding site [chemical binding]; other site 663278007617 homotetramer interface [polypeptide binding]; other site 663278007618 homodimer interface [polypeptide binding]; other site 663278007619 active site 663278007620 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 663278007621 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 663278007622 dimer interface [polypeptide binding]; other site 663278007623 active site 663278007624 CoA binding pocket [chemical binding]; other site 663278007625 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 663278007626 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 663278007627 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 663278007628 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 663278007629 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 663278007630 shikimate binding site; other site 663278007631 NAD(P) binding site [chemical binding]; other site 663278007632 shikimate kinase; Reviewed; Region: aroK; PRK00131 663278007633 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 663278007634 ADP binding site [chemical binding]; other site 663278007635 magnesium binding site [ion binding]; other site 663278007636 putative shikimate binding site; other site 663278007637 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 663278007638 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 663278007639 Prephenate dehydrogenase; Region: PDH; pfam02153 663278007640 prephenate dehydrogenase; Validated; Region: PRK08507 663278007641 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 663278007642 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 663278007643 active site 663278007644 dimer interface [polypeptide binding]; other site 663278007645 metal binding site [ion binding]; metal-binding site 663278007646 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 663278007647 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 663278007648 hinge; other site 663278007649 active site 663278007650 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 663278007651 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 663278007652 Tetramer interface [polypeptide binding]; other site 663278007653 active site 663278007654 FMN-binding site [chemical binding]; other site 663278007655 Chorismate mutase type II; Region: CM_2; pfam01817 663278007656 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 663278007657 Prephenate dehydratase; Region: PDT; pfam00800 663278007658 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 663278007659 putative L-Phe binding site [chemical binding]; other site 663278007660 enolase; Provisional; Region: eno; PRK00077 663278007661 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 663278007662 dimer interface [polypeptide binding]; other site 663278007663 metal binding site [ion binding]; metal-binding site 663278007664 substrate binding pocket [chemical binding]; other site 663278007665 Chain length determinant protein; Region: Wzz; cl15801 663278007666 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 663278007667 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278007668 Magnesium ion binding site [ion binding]; other site 663278007669 Bacterial sugar transferase; Region: Bac_transf; pfam02397 663278007670 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 663278007671 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 663278007672 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 663278007673 ABC transporter; Region: ABC_tran_2; pfam12848 663278007674 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 663278007675 UreD urease accessory protein; Region: UreD; pfam01774 663278007676 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 663278007677 G1 box; other site 663278007678 GTP/Mg2+ binding site [chemical binding]; other site 663278007679 G2 box; other site 663278007680 Switch I region; other site 663278007681 G3 box; other site 663278007682 Switch II region; other site 663278007683 G4 box; other site 663278007684 G5 box; other site 663278007685 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 663278007686 UreF; Region: UreF; pfam01730 663278007687 urease subunit alpha; Reviewed; Region: ureC; PRK13207 663278007688 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 663278007689 subunit interactions [polypeptide binding]; other site 663278007690 active site 663278007691 flap region; other site 663278007692 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 663278007693 gamma-beta subunit interface [polypeptide binding]; other site 663278007694 alpha-beta subunit interface [polypeptide binding]; other site 663278007695 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 663278007696 alpha-gamma subunit interface [polypeptide binding]; other site 663278007697 beta-gamma subunit interface [polypeptide binding]; other site 663278007698 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 663278007699 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 663278007700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 663278007701 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 663278007702 active site 663278007703 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 663278007704 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 663278007705 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 663278007706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 663278007707 nucleotide binding region [chemical binding]; other site 663278007708 SEC-C motif; Region: SEC-C; pfam02810 663278007709 polyphosphate kinase; Provisional; Region: PRK05443 663278007710 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 663278007711 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 663278007712 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 663278007713 putative active site [active] 663278007714 catalytic site [active] 663278007715 Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169 663278007716 putative domain interface [polypeptide binding]; other site 663278007717 putative active site [active] 663278007718 catalytic site [active] 663278007719 exopolyphosphatase; Region: exo_poly_only; TIGR03706 663278007720 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 663278007721 Predicted membrane protein [Function unknown]; Region: COG2323 663278007722 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 663278007723 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 663278007724 ATP cone domain; Region: ATP-cone; pfam03477 663278007725 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 663278007726 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 663278007727 Protein export membrane protein; Region: SecD_SecF; pfam02355 663278007728 protein-export membrane protein SecD; Region: secD; TIGR01129 663278007729 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 663278007730 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 663278007731 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 663278007732 tetramer interface [polypeptide binding]; other site 663278007733 active site 663278007734 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 663278007735 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 663278007736 inhibitor-cofactor binding pocket; inhibition site 663278007737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278007738 catalytic residue [active] 663278007739 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 663278007740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278007741 Coenzyme A binding pocket [chemical binding]; other site 663278007742 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 663278007743 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 663278007744 G1 box; other site 663278007745 putative GEF interaction site [polypeptide binding]; other site 663278007746 GTP/Mg2+ binding site [chemical binding]; other site 663278007747 Switch I region; other site 663278007748 G2 box; other site 663278007749 G3 box; other site 663278007750 Switch II region; other site 663278007751 G4 box; other site 663278007752 G5 box; other site 663278007753 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 663278007754 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 663278007755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 663278007756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278007757 homodimer interface [polypeptide binding]; other site 663278007758 catalytic residue [active] 663278007759 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 663278007760 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 663278007761 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 663278007762 4Fe-4S binding domain; Region: Fer4; pfam00037 663278007763 4Fe-4S binding domain; Region: Fer4; pfam00037 663278007764 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 663278007765 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 663278007766 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 663278007767 active site 663278007768 metal binding site [ion binding]; metal-binding site 663278007769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 663278007770 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 663278007771 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 663278007772 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 663278007773 active site 663278007774 dimer interface [polypeptide binding]; other site 663278007775 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 663278007776 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 663278007777 active site 663278007778 FMN binding site [chemical binding]; other site 663278007779 substrate binding site [chemical binding]; other site 663278007780 3Fe-4S cluster binding site [ion binding]; other site 663278007781 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 663278007782 domain interface; other site 663278007783 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 663278007784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 663278007785 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 663278007786 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 663278007787 non-heme iron binding site [ion binding]; other site 663278007788 dimer interface [polypeptide binding]; other site 663278007789 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 663278007790 non-heme iron binding site [ion binding]; other site 663278007791 dimer interface [polypeptide binding]; other site 663278007792 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 663278007793 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 663278007794 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 663278007795 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 663278007796 tetramer (dimer of dimers) interface [polypeptide binding]; other site 663278007797 NAD binding site [chemical binding]; other site 663278007798 dimer interface [polypeptide binding]; other site 663278007799 substrate binding site [chemical binding]; other site 663278007800 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 663278007801 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 663278007802 active site 663278007803 FMN binding site [chemical binding]; other site 663278007804 substrate binding site [chemical binding]; other site 663278007805 homotetramer interface [polypeptide binding]; other site 663278007806 catalytic residue [active] 663278007807 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 663278007808 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 663278007809 intersubunit interface [polypeptide binding]; other site 663278007810 active site 663278007811 zinc binding site [ion binding]; other site 663278007812 Na+ binding site [ion binding]; other site 663278007813 hypothetical protein; Provisional; Region: PRK06851 663278007814 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 663278007815 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 663278007816 Fe-S cluster binding site [ion binding]; other site 663278007817 active site 663278007818 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 663278007819 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 663278007820 Propanediol utilisation protein PduL; Region: PduL; pfam06130 663278007821 Propanediol utilisation protein PduL; Region: PduL; pfam06130 663278007822 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 663278007823 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 663278007824 RNA binding site [nucleotide binding]; other site 663278007825 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 663278007826 RNA binding site [nucleotide binding]; other site 663278007827 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 663278007828 peptide chain release factor 1; Validated; Region: prfA; PRK00591 663278007829 This domain is found in peptide chain release factors; Region: PCRF; smart00937 663278007830 RF-1 domain; Region: RF-1; pfam00472 663278007831 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 663278007832 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 663278007833 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 663278007834 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 663278007835 CoA-binding site [chemical binding]; other site 663278007836 ATP-binding [chemical binding]; other site 663278007837 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 663278007838 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 663278007839 N-acetyl-D-glucosamine binding site [chemical binding]; other site 663278007840 catalytic residue [active] 663278007841 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 663278007842 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 663278007843 oligomer interface [polypeptide binding]; other site 663278007844 putative active site [active] 663278007845 metal binding site [ion binding]; metal-binding site 663278007846 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 663278007847 diiron binding motif [ion binding]; other site 663278007848 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 663278007849 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 663278007850 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 663278007851 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 663278007852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 663278007853 metal binding site [ion binding]; metal-binding site 663278007854 active site 663278007855 I-site; other site 663278007856 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 663278007857 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 663278007858 Heavy-metal-associated domain; Region: HMA; pfam00403 663278007859 metal-binding site [ion binding] 663278007860 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 663278007861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 663278007862 dimerization interface [polypeptide binding]; other site 663278007863 putative DNA binding site [nucleotide binding]; other site 663278007864 putative Zn2+ binding site [ion binding]; other site 663278007865 Transposase, Mutator family; Region: Transposase_mut; pfam00872 663278007866 MULE transposase domain; Region: MULE; pfam10551 663278007867 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 663278007868 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 663278007869 trimer interface [polypeptide binding]; other site 663278007870 active site 663278007871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 663278007872 Coenzyme A binding pocket [chemical binding]; other site 663278007873 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 663278007874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 663278007875 inhibitor-cofactor binding pocket; inhibition site 663278007876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 663278007877 catalytic residue [active] 663278007878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 663278007879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 663278007880 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 663278007881 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 663278007882 dimer interface [polypeptide binding]; other site 663278007883 PYR/PP interface [polypeptide binding]; other site 663278007884 TPP binding site [chemical binding]; other site 663278007885 substrate binding site [chemical binding]; other site 663278007886 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 663278007887 Domain of unknown function; Region: EKR; smart00890 663278007888 4Fe-4S binding domain; Region: Fer4_6; pfam12837 663278007889 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 663278007890 TPP-binding site [chemical binding]; other site 663278007891 dimer interface [polypeptide binding]; other site 663278007892 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 663278007893 Domain of unknown function DUF21; Region: DUF21; pfam01595 663278007894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 663278007895 Transporter associated domain; Region: CorC_HlyC; pfam03471 663278007896 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 663278007897 active site 663278007898 putative catalytic site [active] 663278007899 DNA binding site [nucleotide binding] 663278007900 putative phosphate binding site [ion binding]; other site 663278007901 metal binding site A [ion binding]; metal-binding site 663278007902 AP binding site [nucleotide binding]; other site 663278007903 metal binding site B [ion binding]; metal-binding site 663278007904 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 663278007905 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 663278007906 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 663278007907 active site 663278007908 substrate binding site [chemical binding]; other site 663278007909 metal binding site [ion binding]; metal-binding site 663278007910 TSCPD domain; Region: TSCPD; cl14834 663278007911 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 663278007912 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 663278007913 active site 663278007914 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 663278007915 ABC-2 type transporter; Region: ABC2_membrane; cl17235 663278007916 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 663278007917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 663278007918 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 663278007919 Walker A/P-loop; other site 663278007920 ATP binding site [chemical binding]; other site 663278007921 Q-loop/lid; other site 663278007922 ABC transporter signature motif; other site 663278007923 Walker B; other site 663278007924 D-loop; other site 663278007925 H-loop/switch region; other site 663278007926 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 663278007927 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 663278007928 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 663278007929 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 663278007930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 663278007931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 663278007932 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 663278007933 Predicted membrane protein [Function unknown]; Region: COG1511 663278007934 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 663278007935 stage II sporulation protein E; Region: spore_II_E; TIGR02865 663278007936 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 663278007937 Putative amidase domain; Region: Amidase_6; pfam12671 663278007938 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 663278007939 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 663278007940 active site 663278007941 Transglycosylase; Region: Transgly; pfam00912 663278007942 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 663278007943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 663278007944 Collagen binding domain; Region: Collagen_bind; pfam05737 663278007945 Collagen binding domain; Region: Collagen_bind; pfam05737 663278007946 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007947 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007948 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007949 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007950 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007951 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007952 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007953 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007954 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007955 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007956 Cna protein B-type domain; Region: Cna_B; pfam05738 663278007957 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 663278007958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 663278007959 active site 663278007960 phosphorylation site [posttranslational modification] 663278007961 intermolecular recognition site; other site 663278007962 dimerization interface [polypeptide binding]; other site 663278007963 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 663278007964 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 663278007965 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 663278007966 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 663278007967 active site 663278007968 P-loop; other site 663278007969 phosphorylation site [posttranslational modification] 663278007970 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 663278007971 active site 663278007972 P-loop; other site 663278007973 phosphorylation site [posttranslational modification] 663278007974 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 663278007975 PRD domain; Region: PRD; pfam00874 663278007976 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 663278007977 active site 663278007978 P-loop; other site 663278007979 phosphorylation site [posttranslational modification] 663278007980 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 663278007981 active site 663278007982 phosphorylation site [posttranslational modification] 663278007983 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 663278007984 active site 663278007985 phosphorylation site [posttranslational modification] 663278007986 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 663278007987 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 663278007988 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 663278007989 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 663278007990 dimerization domain swap beta strand [polypeptide binding]; other site 663278007991 regulatory protein interface [polypeptide binding]; other site 663278007992 active site 663278007993 regulatory phosphorylation site [posttranslational modification]; other site 663278007994 sporulation sigma factor SigK; Reviewed; Region: PRK05803 663278007995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 663278007996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 663278007997 DNA binding residues [nucleotide binding] 663278007998 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 663278007999 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 663278008000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 663278008001 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 663278008002 5'-nucleotidase; Provisional; Region: PRK03826 663278008003 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 663278008004 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 663278008005 putative metal binding site [ion binding]; other site 663278008006 aspartate kinase; Reviewed; Region: PRK06635 663278008007 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 663278008008 putative nucleotide binding site [chemical binding]; other site 663278008009 putative catalytic residues [active] 663278008010 putative Mg ion binding site [ion binding]; other site 663278008011 putative aspartate binding site [chemical binding]; other site 663278008012 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 663278008013 putative allosteric regulatory site; other site 663278008014 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 663278008015 putative allosteric regulatory residue; other site 663278008016 homoserine kinase; Provisional; Region: PRK01212 663278008017 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 663278008018 homoserine dehydrogenase; Provisional; Region: PRK06349 663278008019 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 663278008020 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 663278008021 hypothetical protein; Provisional; Region: PRK04435 663278008022 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 663278008023 Domain of unknown function DUF20; Region: UPF0118; pfam01594 663278008024 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 663278008025 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 663278008026 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 663278008027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 663278008028 motif II; other site 663278008029 DivIVA protein; Region: DivIVA; pfam05103 663278008030 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 663278008031 catalytic residues [active] 663278008032 dimer interface [polypeptide binding]; other site 663278008033 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 663278008034 Predicted membrane protein [Function unknown]; Region: COG3463 663278008035 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 663278008036 trimer interface [polypeptide binding]; other site 663278008037 active site 663278008038 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 663278008039 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 663278008040 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 663278008041 active site 663278008042 Riboflavin kinase; Region: Flavokinase; pfam01687 663278008043 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 663278008044 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 663278008045 RNA binding site [nucleotide binding]; other site 663278008046 active site 663278008047 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 663278008048 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 663278008049 DHH family; Region: DHH; pfam01368 663278008050 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 663278008051 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 663278008052 translation initiation factor IF-2; Region: IF-2; TIGR00487 663278008053 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 663278008054 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 663278008055 G1 box; other site 663278008056 putative GEF interaction site [polypeptide binding]; other site 663278008057 GTP/Mg2+ binding site [chemical binding]; other site 663278008058 Switch I region; other site 663278008059 G2 box; other site 663278008060 G3 box; other site 663278008061 Switch II region; other site 663278008062 G4 box; other site 663278008063 G5 box; other site 663278008064 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 663278008065 Translation-initiation factor 2; Region: IF-2; pfam11987 663278008066 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 663278008067 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 663278008068 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 663278008069 putative RNA binding cleft [nucleotide binding]; other site 663278008070 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 663278008071 NusA N-terminal domain; Region: NusA_N; pfam08529 663278008072 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 663278008073 RNA binding site [nucleotide binding]; other site 663278008074 homodimer interface [polypeptide binding]; other site 663278008075 NusA-like KH domain; Region: KH_5; pfam13184 663278008076 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 663278008077 G-X-X-G motif; other site 663278008078 Sm and related proteins; Region: Sm_like; cl00259 663278008079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 663278008080 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 663278008081 putative oligomer interface [polypeptide binding]; other site 663278008082 putative RNA binding site [nucleotide binding]; other site 663278008083 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 663278008084 active site 663278008085 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 663278008086 active site 2 [active] 663278008087 seryl-tRNA synthetase; Provisional; Region: PRK05431 663278008088 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 663278008089 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 663278008090 dimer interface [polypeptide binding]; other site 663278008091 active site 663278008092 motif 1; other site 663278008093 motif 2; other site 663278008094 motif 3; other site 663278008095 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 663278008096 ParB-like nuclease domain; Region: ParB; smart00470 663278008097 KorB domain; Region: KorB; pfam08535 663278008098 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 663278008099 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278008100 P-loop; other site 663278008101 Magnesium ion binding site [ion binding]; other site 663278008102 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 663278008103 Magnesium ion binding site [ion binding]; other site 663278008104 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 663278008105 ParB-like nuclease domain; Region: ParBc; pfam02195 663278008106 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 663278008107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 663278008108 S-adenosylmethionine binding site [chemical binding]; other site 663278008109 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 663278008110 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 663278008111 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 663278008112 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 663278008113 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 663278008114 trmE is a tRNA modification GTPase; Region: trmE; cd04164 663278008115 G1 box; other site 663278008116 GTP/Mg2+ binding site [chemical binding]; other site 663278008117 Switch I region; other site 663278008118 G2 box; other site 663278008119 Switch II region; other site 663278008120 G3 box; other site 663278008121 G4 box; other site 663278008122 G5 box; other site 663278008123 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 663278008124 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 663278008125 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 663278008126 G-X-X-G motif; other site 663278008127 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 663278008128 RxxxH motif; other site 663278008129 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 663278008130 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 663278008131 Haemolytic domain; Region: Haemolytic; pfam01809 663278008132 Ribonuclease P; Region: Ribonuclease_P; cl00457 663278008133 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399