-- dump date 20140619_091820 -- class Genbank::misc_feature -- table misc_feature_note -- id note 903814000001 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 903814000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 903814000003 DnaA N-terminal domain; Region: DnaA_N; pfam11638 903814000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814000005 Walker A motif; other site 903814000006 ATP binding site [chemical binding]; other site 903814000007 Walker B motif; other site 903814000008 arginine finger; other site 903814000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 903814000010 DnaA box-binding interface [nucleotide binding]; other site 903814000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 903814000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 903814000013 putative DNA binding surface [nucleotide binding]; other site 903814000014 dimer interface [polypeptide binding]; other site 903814000015 beta-clamp/clamp loader binding surface; other site 903814000016 beta-clamp/translesion DNA polymerase binding surface; other site 903814000017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814000018 RNA binding surface [nucleotide binding]; other site 903814000019 recombination protein F; Reviewed; Region: recF; PRK00064 903814000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814000021 Walker A/P-loop; other site 903814000022 ATP binding site [chemical binding]; other site 903814000023 Q-loop/lid; other site 903814000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814000025 ABC transporter signature motif; other site 903814000026 Walker B; other site 903814000027 D-loop; other site 903814000028 H-loop/switch region; other site 903814000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 903814000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814000031 Mg2+ binding site [ion binding]; other site 903814000032 G-X-G motif; other site 903814000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 903814000034 anchoring element; other site 903814000035 dimer interface [polypeptide binding]; other site 903814000036 ATP binding site [chemical binding]; other site 903814000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 903814000038 active site 903814000039 putative metal-binding site [ion binding]; other site 903814000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 903814000041 DNA gyrase subunit A; Validated; Region: PRK05560 903814000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 903814000043 CAP-like domain; other site 903814000044 active site 903814000045 primary dimer interface [polypeptide binding]; other site 903814000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 903814000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 903814000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 903814000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 903814000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 903814000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 903814000052 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 903814000053 active site 903814000054 phosphorylation site [posttranslational modification] 903814000055 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 903814000056 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 903814000057 substrate binding site [chemical binding]; other site 903814000058 hexamer interface [polypeptide binding]; other site 903814000059 metal binding site [ion binding]; metal-binding site 903814000060 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 903814000061 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 903814000062 Chromate transporter; Region: Chromate_transp; pfam02417 903814000063 Chromate transporter; Region: Chromate_transp; pfam02417 903814000064 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814000065 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 903814000066 intersubunit interface [polypeptide binding]; other site 903814000067 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814000068 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814000069 Walker A/P-loop; other site 903814000070 ATP binding site [chemical binding]; other site 903814000071 Q-loop/lid; other site 903814000072 ABC transporter signature motif; other site 903814000073 Walker B; other site 903814000074 D-loop; other site 903814000075 H-loop/switch region; other site 903814000076 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 903814000077 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814000078 ABC-ATPase subunit interface; other site 903814000079 dimer interface [polypeptide binding]; other site 903814000080 putative PBP binding regions; other site 903814000081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814000082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814000083 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 903814000084 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814000085 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814000086 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814000087 Bacterial Ig-like domain; Region: Big_5; pfam13205 903814000088 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 903814000089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814000090 FeS/SAM binding site; other site 903814000091 UMP phosphatase; Provisional; Region: PRK10444 903814000092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814000093 active site 903814000094 motif I; other site 903814000095 motif II; other site 903814000096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814000097 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 903814000098 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 903814000099 CPxP motif; other site 903814000100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814000101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814000102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 903814000103 dimerization interface [polypeptide binding]; other site 903814000104 Sulphur transport; Region: Sulf_transp; pfam04143 903814000105 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 903814000106 CPxP motif; other site 903814000107 Sulphur transport; Region: Sulf_transp; pfam04143 903814000108 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 903814000109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814000110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814000111 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 903814000112 catalytic residues [active] 903814000113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814000114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814000115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 903814000116 dimerization interface [polypeptide binding]; other site 903814000117 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 903814000118 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 903814000119 putative NAD(P) binding site [chemical binding]; other site 903814000120 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 903814000121 Proline racemase; Region: Pro_racemase; pfam05544 903814000122 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814000123 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814000124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814000125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814000126 DNA binding residues [nucleotide binding] 903814000127 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814000128 intersubunit interface [polypeptide binding]; other site 903814000129 active site 903814000130 catalytic residue [active] 903814000131 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 903814000132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814000133 nucleotide binding site [chemical binding]; other site 903814000134 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814000135 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 903814000136 putative NAD(P) binding site [chemical binding]; other site 903814000137 catalytic Zn binding site [ion binding]; other site 903814000138 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 903814000139 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 903814000140 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 903814000141 putative active site [active] 903814000142 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814000143 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814000144 nucleotide binding site [chemical binding]; other site 903814000145 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 903814000146 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 903814000147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814000148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814000149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814000150 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814000151 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814000152 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814000153 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814000154 intersubunit interface [polypeptide binding]; other site 903814000155 active site 903814000156 catalytic residue [active] 903814000157 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 903814000158 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 903814000159 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814000160 putative NAD(P) binding site [chemical binding]; other site 903814000161 catalytic Zn binding site [ion binding]; other site 903814000162 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814000163 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 903814000164 putative NAD(P) binding site [chemical binding]; other site 903814000165 catalytic Zn binding site [ion binding]; other site 903814000166 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 903814000167 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 903814000168 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 903814000169 putative active site [active] 903814000170 YcxB-like protein; Region: YcxB; pfam14317 903814000171 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814000172 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 903814000173 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814000174 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 903814000175 active site 903814000176 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 903814000177 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814000178 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814000179 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814000180 Bacteriophage holin; Region: Phage_holin_1; pfam04531 903814000181 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814000184 putative substrate translocation pore; other site 903814000185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814000186 PAS domain; Region: PAS_9; pfam13426 903814000187 putative active site [active] 903814000188 heme pocket [chemical binding]; other site 903814000189 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814000190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814000191 Walker A motif; other site 903814000192 ATP binding site [chemical binding]; other site 903814000193 Walker B motif; other site 903814000194 arginine finger; other site 903814000195 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 903814000196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814000197 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814000198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814000199 Walker A motif; other site 903814000200 ATP binding site [chemical binding]; other site 903814000201 Walker B motif; other site 903814000202 arginine finger; other site 903814000203 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000204 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 903814000205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814000206 putative substrate translocation pore; other site 903814000207 metabolite-proton symporter; Region: 2A0106; TIGR00883 903814000208 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000209 BCCT family transporter; Region: BCCT; pfam02028 903814000210 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 903814000211 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 903814000212 NAD(P) binding site [chemical binding]; other site 903814000213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814000214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814000215 non-specific DNA binding site [nucleotide binding]; other site 903814000216 salt bridge; other site 903814000217 sequence-specific DNA binding site [nucleotide binding]; other site 903814000218 Protein of unknown function (DUF739); Region: DUF739; pfam05339 903814000219 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 903814000220 active site 903814000221 catalytic residues [active] 903814000222 Uncharacterized conserved protein [Function unknown]; Region: COG4925 903814000223 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 903814000224 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814000225 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 903814000226 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 903814000227 trimer interface [polypeptide binding]; other site 903814000228 active site 903814000229 substrate binding site [chemical binding]; other site 903814000230 CoA binding site [chemical binding]; other site 903814000231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814000232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814000233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 903814000234 dimerization interface [polypeptide binding]; other site 903814000235 Predicted permeases [General function prediction only]; Region: COG0730 903814000236 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 903814000237 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814000238 Holin family; Region: Phage_holin_4; pfam05105 903814000239 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814000240 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814000241 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814000242 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 903814000243 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814000244 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 903814000245 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 903814000246 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814000247 Int/Topo IB signature motif; other site 903814000248 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814000249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814000250 DNA-binding site [nucleotide binding]; DNA binding site 903814000251 UTRA domain; Region: UTRA; pfam07702 903814000252 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814000253 B12 binding site [chemical binding]; other site 903814000254 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000255 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000256 BCCT family transporter; Region: BCCT; pfam02028 903814000257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814000258 putative substrate translocation pore; other site 903814000259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814000260 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 903814000261 transmembrane helices; other site 903814000262 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814000263 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814000264 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 903814000265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814000266 S-adenosylmethionine binding site [chemical binding]; other site 903814000267 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814000268 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 903814000269 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814000270 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814000271 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 903814000272 transmembrane helices; other site 903814000273 Cache domain; Region: Cache_1; pfam02743 903814000274 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 903814000275 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814000276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814000277 metal binding site [ion binding]; metal-binding site 903814000278 active site 903814000279 I-site; other site 903814000280 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814000282 putative substrate translocation pore; other site 903814000283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814000284 PAS domain; Region: PAS_9; pfam13426 903814000285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814000286 putative active site [active] 903814000287 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 903814000288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814000289 Walker A motif; other site 903814000290 ATP binding site [chemical binding]; other site 903814000291 Walker B motif; other site 903814000292 arginine finger; other site 903814000293 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 903814000294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 903814000295 binding surface 903814000296 TPR motif; other site 903814000297 SEC-C motif; Region: SEC-C; pfam02810 903814000298 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814000299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814000300 non-specific DNA binding site [nucleotide binding]; other site 903814000301 salt bridge; other site 903814000302 sequence-specific DNA binding site [nucleotide binding]; other site 903814000303 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814000304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814000305 metal binding site [ion binding]; metal-binding site 903814000306 active site 903814000307 I-site; other site 903814000308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814000309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814000310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814000311 metal binding site [ion binding]; metal-binding site 903814000312 active site 903814000313 I-site; other site 903814000314 Homoserine O-succinyltransferase; Region: HTS; pfam04204 903814000315 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 903814000316 proposed active site lysine [active] 903814000317 conserved cys residue [active] 903814000318 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 903814000319 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 903814000320 dimer interface [polypeptide binding]; other site 903814000321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814000322 catalytic residue [active] 903814000323 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 903814000324 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 903814000325 homodimer interface [polypeptide binding]; other site 903814000326 substrate-cofactor binding pocket; other site 903814000327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814000328 catalytic residue [active] 903814000329 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 903814000330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814000331 Zn2+ binding site [ion binding]; other site 903814000332 Mg2+ binding site [ion binding]; other site 903814000333 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 903814000334 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 903814000335 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 903814000336 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 903814000337 prephenate dehydrogenase; Validated; Region: PRK08507 903814000338 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 903814000339 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 903814000340 active site 903814000341 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 903814000342 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 903814000343 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 903814000344 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 903814000345 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 903814000346 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 903814000347 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 903814000348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 903814000349 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 903814000350 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 903814000351 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 903814000352 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 903814000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814000354 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 903814000355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814000356 S-adenosylmethionine binding site [chemical binding]; other site 903814000357 DNA replication protein DnaC; Validated; Region: PRK06835 903814000358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814000359 Walker A motif; other site 903814000360 ATP binding site [chemical binding]; other site 903814000361 Walker B motif; other site 903814000362 arginine finger; other site 903814000363 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 903814000364 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 903814000365 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 903814000366 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 903814000367 hinge; other site 903814000368 active site 903814000369 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 903814000370 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 903814000371 NodB motif; other site 903814000372 active site 903814000373 catalytic site [active] 903814000374 Zn binding site [ion binding]; other site 903814000375 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 903814000376 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 903814000377 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 903814000378 protein binding site [polypeptide binding]; other site 903814000379 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 903814000380 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 903814000381 active site 903814000382 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 903814000383 Transcriptional regulators [Transcription]; Region: MarR; COG1846 903814000384 MarR family; Region: MarR_2; pfam12802 903814000385 Response regulator receiver domain; Region: Response_reg; pfam00072 903814000386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814000387 active site 903814000388 phosphorylation site [posttranslational modification] 903814000389 intermolecular recognition site; other site 903814000390 dimerization interface [polypeptide binding]; other site 903814000391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 903814000392 Histidine kinase; Region: His_kinase; pfam06580 903814000393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814000394 Mg2+ binding site [ion binding]; other site 903814000395 G-X-G motif; other site 903814000396 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 903814000397 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 903814000398 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814000399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814000400 metal binding site [ion binding]; metal-binding site 903814000401 active site 903814000402 I-site; other site 903814000403 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814000404 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 903814000405 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814000406 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 903814000407 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 903814000408 active site 903814000409 metal binding site [ion binding]; metal-binding site 903814000410 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 903814000411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814000412 active site 903814000413 motif I; other site 903814000414 motif II; other site 903814000415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814000416 Glucitol operon activator protein (GutM); Region: GutM; cl01890 903814000417 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 903814000418 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 903814000419 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 903814000420 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 903814000421 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 903814000422 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 903814000423 dimerization domain swap beta strand [polypeptide binding]; other site 903814000424 regulatory protein interface [polypeptide binding]; other site 903814000425 active site 903814000426 regulatory phosphorylation site [posttranslational modification]; other site 903814000427 aspartate aminotransferase; Provisional; Region: PRK07568 903814000428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814000429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814000430 homodimer interface [polypeptide binding]; other site 903814000431 catalytic residue [active] 903814000432 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 903814000433 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 903814000434 generic binding surface I; other site 903814000435 generic binding surface II; other site 903814000436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814000437 Zn2+ binding site [ion binding]; other site 903814000438 Mg2+ binding site [ion binding]; other site 903814000439 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 903814000440 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 903814000441 minor groove reading motif; other site 903814000442 helix-hairpin-helix signature motif; other site 903814000443 substrate binding pocket [chemical binding]; other site 903814000444 active site 903814000445 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 903814000446 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 903814000447 DNA binding and oxoG recognition site [nucleotide binding] 903814000448 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 903814000449 Domain of unknown function (DUF348); Region: DUF348; pfam03990 903814000450 G5 domain; Region: G5; pfam07501 903814000451 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 903814000452 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 903814000453 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 903814000454 homodimer interface [polypeptide binding]; other site 903814000455 substrate-cofactor binding pocket; other site 903814000456 catalytic residue [active] 903814000457 CHC2 zinc finger; Region: zf-CHC2; cl17510 903814000458 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 903814000459 Toprim-like; Region: Toprim_2; pfam13155 903814000460 Cna protein B-type domain; Region: Cna_B; pfam05738 903814000461 Cna protein B-type domain; Region: Cna_B; pfam05738 903814000462 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 903814000463 Cna protein B-type domain; Region: Cna_B; pfam05738 903814000464 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 903814000465 active site 903814000466 catalytic site [active] 903814000467 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 903814000468 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814000469 P-loop; other site 903814000470 Magnesium ion binding site [ion binding]; other site 903814000471 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814000472 ParB-like nuclease domain; Region: ParBc; pfam02195 903814000473 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 903814000474 YodL-like; Region: YodL; pfam14191 903814000475 Antirestriction protein (ArdA); Region: ArdA; pfam07275 903814000476 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 903814000477 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 903814000478 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 903814000479 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 903814000480 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 903814000481 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 903814000482 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 903814000483 AAA-like domain; Region: AAA_10; pfam12846 903814000484 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 903814000485 Walker A motif; other site 903814000486 ATP binding site [chemical binding]; other site 903814000487 Walker B motif; other site 903814000488 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 903814000489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814000490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814000491 non-specific DNA binding site [nucleotide binding]; other site 903814000492 salt bridge; other site 903814000493 sequence-specific DNA binding site [nucleotide binding]; other site 903814000494 Fimbrial protein; Region: Fimbrial; cl01416 903814000495 phosphodiesterase; Provisional; Region: PRK12704 903814000496 CHC2 zinc finger; Region: zf-CHC2; cl17510 903814000497 Virulence-associated protein E; Region: VirE; pfam05272 903814000498 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 903814000499 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 903814000500 putative catalytic residues [active] 903814000501 catalytic nucleophile [active] 903814000502 Recombinase; Region: Recombinase; pfam07508 903814000503 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 903814000504 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 903814000505 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 903814000506 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 903814000507 TrbC/VIRB2 family; Region: TrbC; cl01583 903814000508 PrgI family protein; Region: PrgI; pfam12666 903814000509 Domain of unknown function DUF87; Region: DUF87; pfam01935 903814000510 AAA-like domain; Region: AAA_10; pfam12846 903814000511 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 903814000512 N-acetyl-D-glucosamine binding site [chemical binding]; other site 903814000513 catalytic residue [active] 903814000514 CHAP domain; Region: CHAP; cl17642 903814000515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814000516 non-specific DNA binding site [nucleotide binding]; other site 903814000517 salt bridge; other site 903814000518 sequence-specific DNA binding site [nucleotide binding]; other site 903814000519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814000520 dimerization interface [polypeptide binding]; other site 903814000521 putative DNA binding site [nucleotide binding]; other site 903814000522 putative Zn2+ binding site [ion binding]; other site 903814000523 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 903814000524 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 903814000525 4Fe-4S binding domain; Region: Fer4; cl02805 903814000526 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814000527 DGC domain; Region: DGC; cl01742 903814000528 glycine cleavage system protein H; Provisional; Region: PRK13380 903814000529 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 903814000530 lipoyl attachment site [posttranslational modification]; other site 903814000531 DGC domain; Region: DGC; cl01742 903814000532 DGC domain; Region: DGC; cl01742 903814000533 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 903814000534 dimer interface [polypeptide binding]; other site 903814000535 ADP-ribose binding site [chemical binding]; other site 903814000536 active site 903814000537 nudix motif; other site 903814000538 metal binding site [ion binding]; metal-binding site 903814000539 Putative Fe-S cluster; Region: FeS; cl17515 903814000540 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 903814000541 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 903814000542 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814000543 catalytic residue [active] 903814000544 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 903814000545 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 903814000546 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 903814000547 catalytic triad [active] 903814000548 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 903814000549 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 903814000550 P loop; other site 903814000551 Nucleotide binding site [chemical binding]; other site 903814000552 DTAP/Switch II; other site 903814000553 Switch I; other site 903814000554 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 903814000555 P loop; other site 903814000556 Nucleotide binding site [chemical binding]; other site 903814000557 DTAP/Switch II; other site 903814000558 Switch I; other site 903814000559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814000560 dimerization interface [polypeptide binding]; other site 903814000561 putative DNA binding site [nucleotide binding]; other site 903814000562 putative Zn2+ binding site [ion binding]; other site 903814000563 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 903814000564 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 903814000565 Low molecular weight phosphatase family; Region: LMWPc; cl00105 903814000566 active site 903814000567 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 903814000568 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 903814000569 metal ion-dependent adhesion site (MIDAS); other site 903814000570 MoxR-like ATPases [General function prediction only]; Region: COG0714 903814000571 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 903814000572 RNA polymerase sigma-G factor; Region: spore_sigG; TIGR02850 903814000573 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814000574 active site 903814000575 DNA binding site [nucleotide binding] 903814000576 Int/Topo IB signature motif; other site 903814000577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814000578 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 903814000579 metal ion-dependent adhesion site (MIDAS); other site 903814000580 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 903814000581 Cna protein B-type domain; Region: Cna_B; pfam05738 903814000582 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 903814000583 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 903814000584 active site 903814000585 catalytic site [active] 903814000586 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 903814000587 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 903814000588 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 903814000589 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 903814000590 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 903814000591 minor groove reading motif; other site 903814000592 helix-hairpin-helix signature motif; other site 903814000593 substrate binding pocket [chemical binding]; other site 903814000594 active site 903814000595 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 903814000596 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 903814000597 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 903814000598 4Fe-4S binding domain; Region: Fer4; cl02805 903814000599 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 903814000600 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 903814000601 dimer interface [polypeptide binding]; other site 903814000602 PYR/PP interface [polypeptide binding]; other site 903814000603 TPP binding site [chemical binding]; other site 903814000604 substrate binding site [chemical binding]; other site 903814000605 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 903814000606 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 903814000607 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 903814000608 TPP-binding site [chemical binding]; other site 903814000609 putative dimer interface [polypeptide binding]; other site 903814000610 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 903814000611 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 903814000612 aspartate aminotransferase; Provisional; Region: PRK05764 903814000613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814000614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814000615 homodimer interface [polypeptide binding]; other site 903814000616 catalytic residue [active] 903814000617 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 903814000618 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 903814000619 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 903814000620 NAD(P) binding site [chemical binding]; other site 903814000621 MutL protein; Region: MutL; pfam13941 903814000622 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814000623 B12 binding site [chemical binding]; other site 903814000624 Transcriptional regulator [Transcription]; Region: IclR; COG1414 903814000625 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 903814000626 Bacterial transcriptional regulator; Region: IclR; pfam01614 903814000627 Transcriptional regulators [Transcription]; Region: GntR; COG1802 903814000628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814000629 DNA-binding site [nucleotide binding]; DNA binding site 903814000630 FCD domain; Region: FCD; pfam07729 903814000631 Uncharacterized conserved protein [Function unknown]; Region: COG2006 903814000632 Domain of unknown function (DUF362); Region: DUF362; pfam04015 903814000633 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_9; cd12170 903814000634 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814000635 putative ligand binding site [chemical binding]; other site 903814000636 putative NAD binding site [chemical binding]; other site 903814000637 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 903814000638 Na2 binding site [ion binding]; other site 903814000639 putative substrate binding site 1 [chemical binding]; other site 903814000640 Na binding site 1 [ion binding]; other site 903814000641 putative substrate binding site 2 [chemical binding]; other site 903814000642 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 903814000643 AIR carboxylase; Region: AIRC; smart01001 903814000644 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 903814000645 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 903814000646 active site 903814000647 HIGH motif; other site 903814000648 KMSKS motif; other site 903814000649 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 903814000650 tRNA binding surface [nucleotide binding]; other site 903814000651 anticodon binding site; other site 903814000652 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 903814000653 dimer interface [polypeptide binding]; other site 903814000654 putative tRNA-binding site [nucleotide binding]; other site 903814000655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814000656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814000657 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814000658 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814000659 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 903814000660 transmembrane helices; other site 903814000661 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814000662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814000663 non-specific DNA binding site [nucleotide binding]; other site 903814000664 salt bridge; other site 903814000665 sequence-specific DNA binding site [nucleotide binding]; other site 903814000666 Mor transcription activator family; Region: Mor; cl02360 903814000667 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 903814000668 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814000669 Zn2+ binding site [ion binding]; other site 903814000670 Mg2+ binding site [ion binding]; other site 903814000671 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 903814000672 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 903814000673 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 903814000674 metal binding site [ion binding]; metal-binding site 903814000675 dimer interface [polypeptide binding]; other site 903814000676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814000677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814000678 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 903814000679 MFS/sugar transport protein; Region: MFS_2; pfam13347 903814000680 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814000681 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814000682 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 903814000683 transmembrane helices; other site 903814000684 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 903814000685 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814000686 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814000687 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 903814000688 Ligand binding site [chemical binding]; other site 903814000689 Electron transfer flavoprotein domain; Region: ETF; pfam01012 903814000690 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 903814000691 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 903814000692 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 903814000693 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 903814000694 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 903814000695 FAD binding site [chemical binding]; other site 903814000696 homotetramer interface [polypeptide binding]; other site 903814000697 substrate binding pocket [chemical binding]; other site 903814000698 catalytic base [active] 903814000699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 903814000700 active site 903814000701 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 903814000702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814000703 motif II; other site 903814000704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814000705 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814000706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814000707 active site 903814000708 phosphorylation site [posttranslational modification] 903814000709 intermolecular recognition site; other site 903814000710 dimerization interface [polypeptide binding]; other site 903814000711 LytTr DNA-binding domain; Region: LytTR; pfam04397 903814000712 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 903814000713 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 903814000714 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 903814000715 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 903814000716 active site 903814000717 catalytic tetrad [active] 903814000718 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 903814000719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814000720 NAD(P) binding site [chemical binding]; other site 903814000721 active site 903814000722 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 903814000723 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 903814000724 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 903814000725 putative active site [active] 903814000726 catalytic site [active] 903814000727 putative metal binding site [ion binding]; other site 903814000728 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 903814000729 active site 903814000730 DNA binding site [nucleotide binding] 903814000731 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 903814000732 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 903814000733 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814000734 4Fe-4S binding domain; Region: Fer4; pfam00037 903814000735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814000736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814000737 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 903814000738 putative dimerization interface [polypeptide binding]; other site 903814000739 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 903814000740 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 903814000741 Hexamer interface [polypeptide binding]; other site 903814000742 Hexagonal pore residue; other site 903814000743 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 903814000744 Hexamer interface [polypeptide binding]; other site 903814000745 Hexagonal pore residue; other site 903814000746 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 903814000747 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 903814000748 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 903814000749 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 903814000750 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 903814000751 MoaE interaction surface [polypeptide binding]; other site 903814000752 MoeB interaction surface [polypeptide binding]; other site 903814000753 thiocarboxylated glycine; other site 903814000754 Putative Fe-S cluster; Region: FeS; cl17515 903814000755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 903814000756 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 903814000757 MarR family; Region: MarR_2; pfam12802 903814000758 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814000759 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 903814000760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814000761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814000762 non-specific DNA binding site [nucleotide binding]; other site 903814000763 salt bridge; other site 903814000764 sequence-specific DNA binding site [nucleotide binding]; other site 903814000765 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 903814000766 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 903814000767 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814000768 Walker A/P-loop; other site 903814000769 ATP binding site [chemical binding]; other site 903814000770 Q-loop/lid; other site 903814000771 ABC transporter signature motif; other site 903814000772 Walker B; other site 903814000773 D-loop; other site 903814000774 H-loop/switch region; other site 903814000775 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 903814000776 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 903814000777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814000778 PAS domain; Region: PAS_9; pfam13426 903814000779 putative active site [active] 903814000780 heme pocket [chemical binding]; other site 903814000781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814000782 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814000783 Walker A motif; other site 903814000784 ATP binding site [chemical binding]; other site 903814000785 Walker B motif; other site 903814000786 arginine finger; other site 903814000787 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814000788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814000789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814000790 putative substrate translocation pore; other site 903814000791 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 903814000792 AzlC protein; Region: AzlC; pfam03591 903814000793 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 903814000794 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 903814000795 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814000796 DNA binding residues [nucleotide binding] 903814000797 drug binding residues [chemical binding]; other site 903814000798 dimer interface [polypeptide binding]; other site 903814000799 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 903814000800 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 903814000801 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 903814000802 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 903814000803 metal binding site [ion binding]; metal-binding site 903814000804 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 903814000805 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 903814000806 substrate binding site [chemical binding]; other site 903814000807 glutamase interaction surface [polypeptide binding]; other site 903814000808 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 903814000809 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 903814000810 catalytic residues [active] 903814000811 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 903814000812 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 903814000813 putative active site [active] 903814000814 oxyanion strand; other site 903814000815 catalytic triad [active] 903814000816 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 903814000817 putative active site pocket [active] 903814000818 4-fold oligomerization interface [polypeptide binding]; other site 903814000819 metal binding residues [ion binding]; metal-binding site 903814000820 3-fold/trimer interface [polypeptide binding]; other site 903814000821 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 903814000822 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814000823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814000824 homodimer interface [polypeptide binding]; other site 903814000825 catalytic residue [active] 903814000826 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 903814000827 histidinol dehydrogenase; Region: hisD; TIGR00069 903814000828 NAD binding site [chemical binding]; other site 903814000829 dimerization interface [polypeptide binding]; other site 903814000830 product binding site; other site 903814000831 substrate binding site [chemical binding]; other site 903814000832 zinc binding site [ion binding]; other site 903814000833 catalytic residues [active] 903814000834 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 903814000835 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 903814000836 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 903814000837 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 903814000838 dimer interface [polypeptide binding]; other site 903814000839 motif 1; other site 903814000840 active site 903814000841 motif 2; other site 903814000842 motif 3; other site 903814000843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814000844 PAS domain; Region: PAS_9; pfam13426 903814000845 putative active site [active] 903814000846 heme pocket [chemical binding]; other site 903814000847 PAS fold; Region: PAS_3; pfam08447 903814000848 PAS domain S-box; Region: sensory_box; TIGR00229 903814000849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814000850 putative active site [active] 903814000851 heme pocket [chemical binding]; other site 903814000852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814000853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814000854 metal binding site [ion binding]; metal-binding site 903814000855 active site 903814000856 I-site; other site 903814000857 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 903814000858 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 903814000859 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 903814000860 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 903814000861 active site 903814000862 NTP binding site [chemical binding]; other site 903814000863 metal binding triad [ion binding]; metal-binding site 903814000864 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 903814000865 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 903814000866 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 903814000867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814000868 S-adenosylmethionine binding site [chemical binding]; other site 903814000869 Transcriptional regulator PadR-like family; Region: PadR; cl17335 903814000870 Predicted transcriptional regulators [Transcription]; Region: COG1695 903814000871 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 903814000872 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 903814000873 catalytic loop [active] 903814000874 iron binding site [ion binding]; other site 903814000875 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 903814000876 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814000877 substrate binding pocket [chemical binding]; other site 903814000878 dimer interface [polypeptide binding]; other site 903814000879 inhibitor binding site; inhibition site 903814000880 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 903814000881 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 903814000882 Potassium binding sites [ion binding]; other site 903814000883 Cesium cation binding sites [ion binding]; other site 903814000884 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 903814000885 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 903814000886 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 903814000887 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 903814000888 homodimer interface [polypeptide binding]; other site 903814000889 NADP binding site [chemical binding]; other site 903814000890 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 903814000891 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 903814000892 FAD binding site [chemical binding]; other site 903814000893 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 903814000894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814000895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814000896 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 903814000897 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 903814000898 lipoyl attachment site [posttranslational modification]; other site 903814000899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 903814000900 active site 903814000901 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 903814000902 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814000903 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814000904 Uncharacterized conserved protein [Function unknown]; Region: COG1615 903814000905 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 903814000906 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 903814000907 dinuclear metal binding motif [ion binding]; other site 903814000908 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 903814000909 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 903814000910 CAAX protease self-immunity; Region: Abi; pfam02517 903814000911 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 903814000912 active site 903814000913 catalytic residues [active] 903814000914 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 903814000915 catalytic residues [active] 903814000916 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 903814000917 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 903814000918 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 903814000919 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 903814000920 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814000921 active site 903814000922 DNA binding site [nucleotide binding] 903814000923 Int/Topo IB signature motif; other site 903814000924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814000925 Zn2+ binding site [ion binding]; other site 903814000926 Mg2+ binding site [ion binding]; other site 903814000927 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 903814000928 dockerin binding interface; other site 903814000929 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814000930 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 903814000931 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 903814000932 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 903814000933 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 903814000934 Tetratricopeptide repeat; Region: TPR_16; pfam13432 903814000935 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 903814000936 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814000937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814000938 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 903814000939 DNA binding residues [nucleotide binding] 903814000940 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814000941 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814000942 multiple promoter invertase; Provisional; Region: mpi; PRK13413 903814000943 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 903814000944 catalytic residues [active] 903814000945 catalytic nucleophile [active] 903814000946 Presynaptic Site I dimer interface [polypeptide binding]; other site 903814000947 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 903814000948 Synaptic Flat tetramer interface [polypeptide binding]; other site 903814000949 Synaptic Site I dimer interface [polypeptide binding]; other site 903814000950 DNA binding site [nucleotide binding] 903814000951 ornithine aminotransferase-like protein; Provisional; Region: PTZ00125 903814000952 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 903814000953 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814000954 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 903814000955 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 903814000956 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 903814000957 active site 903814000958 P-loop; other site 903814000959 phosphorylation site [posttranslational modification] 903814000960 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 903814000961 active site 903814000962 phosphorylation site [posttranslational modification] 903814000963 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 903814000964 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814000965 putative NAD(P) binding site [chemical binding]; other site 903814000966 catalytic Zn binding site [ion binding]; other site 903814000967 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814000968 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 903814000969 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814000970 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814000971 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 903814000972 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814000973 putative active site [active] 903814000974 MgATP binding site [chemical binding]; other site 903814000975 catalytic site [active] 903814000976 metal binding site [ion binding]; metal-binding site 903814000977 putative xylulose binding site [chemical binding]; other site 903814000978 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814000979 intersubunit interface [polypeptide binding]; other site 903814000980 active site 903814000981 zinc binding site [ion binding]; other site 903814000982 Na+ binding site [ion binding]; other site 903814000983 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 903814000984 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814000985 putative ligand binding site [chemical binding]; other site 903814000986 putative NAD binding site [chemical binding]; other site 903814000987 catalytic site [active] 903814000988 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814000989 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 903814000990 non-specific DNA interactions [nucleotide binding]; other site 903814000991 DNA binding site [nucleotide binding] 903814000992 sequence specific DNA binding site [nucleotide binding]; other site 903814000993 putative cAMP binding site [chemical binding]; other site 903814000994 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814000995 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 903814000996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814000997 active site 903814000998 motif I; other site 903814000999 motif II; other site 903814001000 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814001001 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 903814001002 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 903814001003 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 903814001004 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 903814001005 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 903814001006 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 903814001007 Walker A motif; other site 903814001008 ATP binding site [chemical binding]; other site 903814001009 Walker B motif; other site 903814001010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814001011 dimerization interface [polypeptide binding]; other site 903814001012 putative DNA binding site [nucleotide binding]; other site 903814001013 putative Zn2+ binding site [ion binding]; other site 903814001014 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 903814001015 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 903814001016 Ligand Binding Site [chemical binding]; other site 903814001017 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 903814001018 AIR carboxylase; Region: AIRC; smart01001 903814001019 Protein of unknown function DUF111; Region: DUF111; pfam01969 903814001020 Uncharacterized conserved protein [Function unknown]; Region: COG3937 903814001021 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 903814001022 ABC1 family; Region: ABC1; cl17513 903814001023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814001024 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814001025 FtsX-like permease family; Region: FtsX; pfam02687 903814001026 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814001027 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814001028 Walker A/P-loop; other site 903814001029 ATP binding site [chemical binding]; other site 903814001030 Q-loop/lid; other site 903814001031 ABC transporter signature motif; other site 903814001032 Walker B; other site 903814001033 D-loop; other site 903814001034 H-loop/switch region; other site 903814001035 HlyD family secretion protein; Region: HlyD_3; pfam13437 903814001036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814001037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001038 active site 903814001039 phosphorylation site [posttranslational modification] 903814001040 intermolecular recognition site; other site 903814001041 dimerization interface [polypeptide binding]; other site 903814001042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814001043 DNA binding site [nucleotide binding] 903814001044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814001045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814001046 dimer interface [polypeptide binding]; other site 903814001047 phosphorylation site [posttranslational modification] 903814001048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814001049 ATP binding site [chemical binding]; other site 903814001050 Mg2+ binding site [ion binding]; other site 903814001051 G-X-G motif; other site 903814001052 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 903814001053 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 903814001054 Carbon starvation protein CstA; Region: CstA; pfam02554 903814001055 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 903814001056 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 903814001057 TspO/MBR family; Region: TspO_MBR; pfam03073 903814001058 maltose O-acetyltransferase; Provisional; Region: PRK10092 903814001059 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 903814001060 active site 903814001061 substrate binding site [chemical binding]; other site 903814001062 trimer interface [polypeptide binding]; other site 903814001063 CoA binding site [chemical binding]; other site 903814001064 Predicted transcriptional regulators [Transcription]; Region: COG1725 903814001065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814001066 DNA-binding site [nucleotide binding]; DNA binding site 903814001067 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 903814001068 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814001069 Walker A/P-loop; other site 903814001070 ATP binding site [chemical binding]; other site 903814001071 Q-loop/lid; other site 903814001072 ABC transporter signature motif; other site 903814001073 Walker B; other site 903814001074 D-loop; other site 903814001075 H-loop/switch region; other site 903814001076 Carboxylesterase family; Region: COesterase; pfam00135 903814001077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 903814001078 substrate binding pocket [chemical binding]; other site 903814001079 catalytic triad [active] 903814001080 Integrase core domain; Region: rve_2; pfam13333 903814001081 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 903814001082 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814001083 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 903814001084 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 903814001085 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 903814001086 glutaminase active site [active] 903814001087 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 903814001088 dimer interface [polypeptide binding]; other site 903814001089 active site 903814001090 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 903814001091 dimer interface [polypeptide binding]; other site 903814001092 active site 903814001093 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814001094 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814001095 B12 binding site [chemical binding]; other site 903814001096 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814001097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814001098 DNA-binding site [nucleotide binding]; DNA binding site 903814001099 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814001100 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814001101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814001102 DNA-binding site [nucleotide binding]; DNA binding site 903814001103 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 903814001104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814001105 putative substrate translocation pore; other site 903814001106 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814001107 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814001108 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 903814001109 B12 binding site [chemical binding]; other site 903814001110 cobalt ligand [ion binding]; other site 903814001111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814001112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814001113 putative substrate translocation pore; other site 903814001114 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814001115 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 903814001116 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814001117 substrate binding pocket [chemical binding]; other site 903814001118 dimer interface [polypeptide binding]; other site 903814001119 inhibitor binding site; inhibition site 903814001120 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 903814001121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814001122 motif II; other site 903814001123 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 903814001124 catalytic core [active] 903814001125 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 903814001126 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 903814001127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 903814001128 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 903814001129 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 903814001130 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001132 metal binding site [ion binding]; metal-binding site 903814001133 active site 903814001134 I-site; other site 903814001135 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 903814001136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814001137 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814001138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814001139 motif II; other site 903814001140 Rrf2 family protein; Region: rrf2_super; TIGR00738 903814001141 Transcriptional regulator; Region: Rrf2; pfam02082 903814001142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814001143 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 903814001144 FtsX-like permease family; Region: FtsX; pfam02687 903814001145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814001146 FtsX-like permease family; Region: FtsX; pfam02687 903814001147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 903814001148 Coenzyme A binding pocket [chemical binding]; other site 903814001149 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 903814001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814001151 non-specific DNA binding site [nucleotide binding]; other site 903814001152 salt bridge; other site 903814001153 sequence-specific DNA binding site [nucleotide binding]; other site 903814001154 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 903814001155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814001156 Walker A/P-loop; other site 903814001157 ATP binding site [chemical binding]; other site 903814001158 Q-loop/lid; other site 903814001159 ABC transporter signature motif; other site 903814001160 Walker B; other site 903814001161 D-loop; other site 903814001162 H-loop/switch region; other site 903814001163 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 903814001164 TfoX C-terminal domain; Region: TfoX_C; pfam04994 903814001165 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814001166 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814001167 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 903814001168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814001169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814001170 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 903814001171 putative active site [active] 903814001172 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 903814001173 active site 903814001174 MobA/MobL family; Region: MobA_MobL; pfam03389 903814001175 Helix-turn-helix domain; Region: HTH_17; cl17695 903814001176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814001177 non-specific DNA binding site [nucleotide binding]; other site 903814001178 salt bridge; other site 903814001179 sequence-specific DNA binding site [nucleotide binding]; other site 903814001180 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814001181 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 903814001182 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814001183 Int/Topo IB signature motif; other site 903814001184 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 903814001185 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 903814001186 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 903814001187 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 903814001188 RNA binding site [nucleotide binding]; other site 903814001189 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814001190 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814001191 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 903814001192 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 903814001193 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 903814001194 putative active site [active] 903814001195 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 903814001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814001197 S-adenosylmethionine binding site [chemical binding]; other site 903814001198 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 903814001199 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 903814001200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814001201 putative substrate translocation pore; other site 903814001202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814001203 dimerization interface [polypeptide binding]; other site 903814001204 putative DNA binding site [nucleotide binding]; other site 903814001205 putative Zn2+ binding site [ion binding]; other site 903814001206 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 903814001207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814001208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814001209 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 903814001210 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 903814001211 active site residue [active] 903814001212 SirA-like protein; Region: SirA; pfam01206 903814001213 CPxP motif; other site 903814001214 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 903814001215 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 903814001216 active site 903814001217 putative catalytic site [active] 903814001218 phosphate binding site A [ion binding]; other site 903814001219 DNA binding site [nucleotide binding] 903814001220 metal binding site A [ion binding]; metal-binding site 903814001221 putative AP binding site [nucleotide binding]; other site 903814001222 putative metal binding site B [ion binding]; other site 903814001223 phosphate binding site B [ion binding]; other site 903814001224 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814001225 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 903814001226 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814001227 putative active site [active] 903814001228 putative xylulose binding site [chemical binding]; other site 903814001229 MgATP binding site [chemical binding]; other site 903814001230 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814001231 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 903814001232 non-specific DNA interactions [nucleotide binding]; other site 903814001233 DNA binding site [nucleotide binding] 903814001234 sequence specific DNA binding site [nucleotide binding]; other site 903814001235 putative cAMP binding site [chemical binding]; other site 903814001236 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814001237 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814001238 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 903814001239 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814001240 putative active site [active] 903814001241 MgATP binding site [chemical binding]; other site 903814001242 catalytic site [active] 903814001243 metal binding site [ion binding]; metal-binding site 903814001244 putative xylulose binding site [chemical binding]; other site 903814001245 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 903814001246 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 903814001247 putative ligand binding site [chemical binding]; other site 903814001248 putative NAD binding site [chemical binding]; other site 903814001249 catalytic site [active] 903814001250 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 903814001251 intersubunit interface [polypeptide binding]; other site 903814001252 active site 903814001253 Zn2+ binding site [ion binding]; other site 903814001254 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 903814001255 intersubunit interface [polypeptide binding]; other site 903814001256 active site 903814001257 Zn2+ binding site [ion binding]; other site 903814001258 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 903814001259 intersubunit interface [polypeptide binding]; other site 903814001260 active site 903814001261 Zn2+ binding site [ion binding]; other site 903814001262 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 903814001263 Collagen binding domain; Region: Collagen_bind; pfam05737 903814001264 Collagen binding domain; Region: Collagen_bind; pfam05737 903814001265 Collagen binding domain; Region: Collagen_bind; pfam05737 903814001266 Collagen binding domain; Region: Collagen_bind; pfam05737 903814001267 Collagen binding domain; Region: Collagen_bind; pfam05737 903814001268 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001269 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001270 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001271 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 903814001272 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 903814001273 trimer interface [polypeptide binding]; other site 903814001274 active site 903814001275 substrate binding site [chemical binding]; other site 903814001276 CoA binding site [chemical binding]; other site 903814001277 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001278 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001279 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 903814001280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814001281 Walker A/P-loop; other site 903814001282 ATP binding site [chemical binding]; other site 903814001283 Q-loop/lid; other site 903814001284 ABC transporter signature motif; other site 903814001285 Walker B; other site 903814001286 D-loop; other site 903814001287 H-loop/switch region; other site 903814001288 ABC transporter; Region: ABC_tran_2; pfam12848 903814001289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814001290 putative acyltransferase; Provisional; Region: PRK05790 903814001291 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 903814001292 dimer interface [polypeptide binding]; other site 903814001293 active site 903814001294 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 903814001295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 903814001296 substrate binding site [chemical binding]; other site 903814001297 oxyanion hole (OAH) forming residues; other site 903814001298 trimer interface [polypeptide binding]; other site 903814001299 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 903814001300 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 903814001301 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 903814001302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 903814001303 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 903814001304 FAD binding site [chemical binding]; other site 903814001305 homotetramer interface [polypeptide binding]; other site 903814001306 substrate binding pocket [chemical binding]; other site 903814001307 catalytic base [active] 903814001308 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 903814001309 Ligand binding site [chemical binding]; other site 903814001310 Electron transfer flavoprotein domain; Region: ETF; pfam01012 903814001311 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 903814001312 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 903814001313 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 903814001314 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 903814001315 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 903814001316 trimer interface [polypeptide binding]; other site 903814001317 putative metal binding site [ion binding]; other site 903814001318 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 903814001319 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 903814001320 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 903814001321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 903814001322 active site 903814001323 HIGH motif; other site 903814001324 nucleotide binding site [chemical binding]; other site 903814001325 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 903814001326 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 903814001327 active site 903814001328 KMSKS motif; other site 903814001329 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 903814001330 tRNA binding surface [nucleotide binding]; other site 903814001331 anticodon binding site; other site 903814001332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814001333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814001334 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814001335 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 903814001336 active site 903814001337 substrate binding site [chemical binding]; other site 903814001338 ATP binding site [chemical binding]; other site 903814001339 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814001340 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 903814001341 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814001342 substrate binding pocket [chemical binding]; other site 903814001343 dimer interface [polypeptide binding]; other site 903814001344 inhibitor binding site; inhibition site 903814001345 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814001346 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814001347 B12 binding site [chemical binding]; other site 903814001348 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814001349 EamA-like transporter family; Region: EamA; pfam00892 903814001350 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 903814001351 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 903814001352 intersubunit interface [polypeptide binding]; other site 903814001353 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 903814001354 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 903814001355 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 903814001356 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814001357 ABC-ATPase subunit interface; other site 903814001358 dimer interface [polypeptide binding]; other site 903814001359 putative PBP binding regions; other site 903814001360 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 903814001361 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 903814001362 Asp23 family; Region: Asp23; pfam03780 903814001363 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001364 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001365 metal binding site [ion binding]; metal-binding site 903814001366 active site 903814001367 I-site; other site 903814001368 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814001369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814001370 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814001371 substrate binding pocket [chemical binding]; other site 903814001372 membrane-bound complex binding site; other site 903814001373 hinge residues; other site 903814001374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814001375 substrate binding pocket [chemical binding]; other site 903814001376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814001377 membrane-bound complex binding site; other site 903814001378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001380 metal binding site [ion binding]; metal-binding site 903814001381 active site 903814001382 I-site; other site 903814001383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814001384 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 903814001385 Prephenate dehydratase; Region: PDT; pfam00800 903814001386 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 903814001387 putative L-Phe binding site [chemical binding]; other site 903814001388 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 903814001389 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 903814001390 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 903814001391 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 903814001392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814001393 motif II; other site 903814001394 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 903814001395 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 903814001396 inhibitor site; inhibition site 903814001397 active site 903814001398 dimer interface [polypeptide binding]; other site 903814001399 catalytic residue [active] 903814001400 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814001401 intersubunit interface [polypeptide binding]; other site 903814001402 active site 903814001403 catalytic residue [active] 903814001404 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 903814001405 classical (c) SDRs; Region: SDR_c; cd05233 903814001406 NAD(P) binding site [chemical binding]; other site 903814001407 active site 903814001408 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814001409 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 903814001410 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814001411 putative active site [active] 903814001412 MgATP binding site [chemical binding]; other site 903814001413 catalytic site [active] 903814001414 metal binding site [ion binding]; metal-binding site 903814001415 putative xylulose binding site [chemical binding]; other site 903814001416 Protein of unknown function DUF89; Region: DUF89; cl15397 903814001417 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 903814001418 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 903814001419 active site 1 [active] 903814001420 dimer interface [polypeptide binding]; other site 903814001421 hexamer interface [polypeptide binding]; other site 903814001422 active site 2 [active] 903814001423 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814001424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814001425 DNA binding residues [nucleotide binding] 903814001426 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814001427 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 903814001428 Amidinotransferase; Region: Amidinotransf; cl12043 903814001429 Bacterial SH3 domain; Region: SH3_3; pfam08239 903814001430 ornithine carbamoyltransferase; Validated; Region: PRK02102 903814001431 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 903814001432 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 903814001433 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 903814001434 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 903814001435 active site 903814001436 substrate binding site [chemical binding]; other site 903814001437 metal binding site [ion binding]; metal-binding site 903814001438 PAS domain; Region: PAS_9; pfam13426 903814001439 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001440 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001441 metal binding site [ion binding]; metal-binding site 903814001442 active site 903814001443 I-site; other site 903814001444 PAS domain; Region: PAS_9; pfam13426 903814001445 PAS domain; Region: PAS_9; pfam13426 903814001446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814001447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814001448 dimer interface [polypeptide binding]; other site 903814001449 phosphorylation site [posttranslational modification] 903814001450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814001451 ATP binding site [chemical binding]; other site 903814001452 Mg2+ binding site [ion binding]; other site 903814001453 G-X-G motif; other site 903814001454 Response regulator receiver domain; Region: Response_reg; pfam00072 903814001455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001456 active site 903814001457 phosphorylation site [posttranslational modification] 903814001458 intermolecular recognition site; other site 903814001459 dimerization interface [polypeptide binding]; other site 903814001460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001461 Response regulator receiver domain; Region: Response_reg; pfam00072 903814001462 active site 903814001463 phosphorylation site [posttranslational modification] 903814001464 intermolecular recognition site; other site 903814001465 dimerization interface [polypeptide binding]; other site 903814001466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001468 metal binding site [ion binding]; metal-binding site 903814001469 active site 903814001470 I-site; other site 903814001471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001473 metal binding site [ion binding]; metal-binding site 903814001474 active site 903814001475 I-site; other site 903814001476 PAS domain; Region: PAS_9; pfam13426 903814001477 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001479 metal binding site [ion binding]; metal-binding site 903814001480 active site 903814001481 I-site; other site 903814001482 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814001483 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814001484 Small, acid-soluble spore protein I; Region: SSPI; cl07940 903814001485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814001486 sequence-specific DNA binding site [nucleotide binding]; other site 903814001487 salt bridge; other site 903814001488 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814001489 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814001490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814001491 PAS fold; Region: PAS_3; pfam08447 903814001492 putative active site [active] 903814001493 heme pocket [chemical binding]; other site 903814001494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001495 metal binding site [ion binding]; metal-binding site 903814001496 active site 903814001497 I-site; other site 903814001498 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814001499 PAS domain; Region: PAS_9; pfam13426 903814001500 PAS fold; Region: PAS_4; pfam08448 903814001501 PAS domain; Region: PAS_9; pfam13426 903814001502 PAS domain; Region: PAS_9; pfam13426 903814001503 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001505 metal binding site [ion binding]; metal-binding site 903814001506 active site 903814001507 I-site; other site 903814001508 PAS domain; Region: PAS_9; pfam13426 903814001509 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 903814001510 GAF domain; Region: GAF; pfam01590 903814001511 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001512 metal binding site [ion binding]; metal-binding site 903814001513 active site 903814001514 I-site; other site 903814001515 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814001516 Cache domain; Region: Cache_1; pfam02743 903814001517 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814001518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814001519 metal binding site [ion binding]; metal-binding site 903814001520 active site 903814001521 I-site; other site 903814001522 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001523 Cna protein B-type domain; Region: Cna_B; pfam05738 903814001524 Bacterial transcriptional activator domain; Region: BTAD; smart01043 903814001525 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 903814001526 alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090 903814001527 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 903814001528 Catalytic site [active] 903814001529 alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090 903814001530 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814001531 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814001532 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814001533 EamA-like transporter family; Region: EamA; pfam00892 903814001534 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 903814001535 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 903814001536 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814001537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814001538 Walker A/P-loop; other site 903814001539 ATP binding site [chemical binding]; other site 903814001540 Q-loop/lid; other site 903814001541 ABC transporter signature motif; other site 903814001542 Walker B; other site 903814001543 D-loop; other site 903814001544 H-loop/switch region; other site 903814001545 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 903814001546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814001547 motif II; other site 903814001548 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 903814001549 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 903814001550 putative catalytic cysteine [active] 903814001551 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 903814001552 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 903814001553 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 903814001554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814001555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814001556 Predicted acetyltransferase [General function prediction only]; Region: COG2388 903814001557 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 903814001558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814001559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814001560 Predicted acetyltransferase [General function prediction only]; Region: COG2388 903814001561 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 903814001562 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 903814001563 ATP-grasp domain; Region: ATP-grasp_4; cl17255 903814001564 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 903814001565 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 903814001566 active site 903814001567 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 903814001568 active site 2 [active] 903814001569 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 903814001570 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 903814001571 active site 903814001572 nucleophile elbow; other site 903814001573 glycogen branching enzyme; Provisional; Region: PRK12313 903814001574 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 903814001575 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 903814001576 active site 903814001577 catalytic site [active] 903814001578 Type II/IV secretion system protein; Region: T2SE; pfam00437 903814001579 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 903814001580 Walker A motif; other site 903814001581 ATP binding site [chemical binding]; other site 903814001582 Walker B motif; other site 903814001583 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 903814001584 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 903814001585 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 903814001586 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 903814001587 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 903814001588 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 903814001589 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 903814001590 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 903814001591 active site 903814001592 catalytic residue [active] 903814001593 dimer interface [polypeptide binding]; other site 903814001594 shikimate kinase; Reviewed; Region: aroK; PRK00131 903814001595 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 903814001596 ADP binding site [chemical binding]; other site 903814001597 magnesium binding site [ion binding]; other site 903814001598 putative shikimate binding site; other site 903814001599 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 903814001600 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 903814001601 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 903814001602 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 903814001603 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814001604 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814001605 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 903814001606 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 903814001607 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 903814001608 Phosphoglycerate kinase; Region: PGK; pfam00162 903814001609 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 903814001610 substrate binding site [chemical binding]; other site 903814001611 hinge regions; other site 903814001612 ADP binding site [chemical binding]; other site 903814001613 catalytic site [active] 903814001614 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 903814001615 triosephosphate isomerase; Provisional; Region: PRK14565 903814001616 substrate binding site [chemical binding]; other site 903814001617 dimer interface [polypeptide binding]; other site 903814001618 catalytic triad [active] 903814001619 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 903814001620 phosphoglyceromutase; Provisional; Region: PRK05434 903814001621 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 903814001622 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 903814001623 Beta-lactamase; Region: Beta-lactamase; pfam00144 903814001624 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 903814001625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814001626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001627 active site 903814001628 phosphorylation site [posttranslational modification] 903814001629 intermolecular recognition site; other site 903814001630 dimerization interface [polypeptide binding]; other site 903814001631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814001632 DNA binding site [nucleotide binding] 903814001633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814001634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814001635 dimer interface [polypeptide binding]; other site 903814001636 phosphorylation site [posttranslational modification] 903814001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814001638 ATP binding site [chemical binding]; other site 903814001639 Mg2+ binding site [ion binding]; other site 903814001640 G-X-G motif; other site 903814001641 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 903814001642 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 903814001643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814001644 catalytic residue [active] 903814001645 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 903814001646 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 903814001647 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 903814001648 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 903814001649 nucleophilic elbow; other site 903814001650 catalytic triad; other site 903814001651 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 903814001652 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 903814001653 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814001654 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 903814001655 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 903814001656 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 903814001657 NodB motif; other site 903814001658 active site 903814001659 catalytic site [active] 903814001660 Zn binding site [ion binding]; other site 903814001661 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 903814001662 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 903814001663 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 903814001664 putative active site [active] 903814001665 catalytic site [active] 903814001666 putative metal binding site [ion binding]; other site 903814001667 Response regulator receiver domain; Region: Response_reg; pfam00072 903814001668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001669 active site 903814001670 phosphorylation site [posttranslational modification] 903814001671 intermolecular recognition site; other site 903814001672 dimerization interface [polypeptide binding]; other site 903814001673 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 903814001674 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 903814001675 Response regulator receiver domain; Region: Response_reg; pfam00072 903814001676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001677 active site 903814001678 phosphorylation site [posttranslational modification] 903814001679 intermolecular recognition site; other site 903814001680 dimerization interface [polypeptide binding]; other site 903814001681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 903814001682 Predicted membrane protein [Function unknown]; Region: COG3212 903814001683 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 903814001684 Response regulator receiver domain; Region: Response_reg; pfam00072 903814001685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001686 active site 903814001687 phosphorylation site [posttranslational modification] 903814001688 intermolecular recognition site; other site 903814001689 dimerization interface [polypeptide binding]; other site 903814001690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 903814001691 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814001692 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 903814001693 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 903814001694 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 903814001695 active site 903814001696 metal binding site [ion binding]; metal-binding site 903814001697 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 903814001698 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 903814001699 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 903814001700 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 903814001701 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 903814001702 dimer interface [polypeptide binding]; other site 903814001703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814001704 catalytic residue [active] 903814001705 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 903814001706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814001707 motif II; other site 903814001708 Rubrerythrin [Energy production and conversion]; Region: COG1592 903814001709 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 903814001710 binuclear metal center [ion binding]; other site 903814001711 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 903814001712 iron binding site [ion binding]; other site 903814001713 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 903814001714 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814001715 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 903814001716 transmembrane helices; other site 903814001717 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814001718 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814001719 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814001720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814001721 putative Zn2+ binding site [ion binding]; other site 903814001722 putative DNA binding site [nucleotide binding]; other site 903814001723 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 903814001724 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 903814001725 active site 903814001726 dimer interface [polypeptide binding]; other site 903814001727 metal binding site [ion binding]; metal-binding site 903814001728 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 903814001729 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 903814001730 hinge; other site 903814001731 active site 903814001732 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 903814001733 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 903814001734 Tetramer interface [polypeptide binding]; other site 903814001735 active site 903814001736 FMN-binding site [chemical binding]; other site 903814001737 Chorismate mutase type II; Region: CM_2; smart00830 903814001738 pyruvate carboxylase; Reviewed; Region: PRK12999 903814001739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 903814001740 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 903814001741 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 903814001742 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 903814001743 active site 903814001744 catalytic residues [active] 903814001745 metal binding site [ion binding]; metal-binding site 903814001746 homodimer binding site [polypeptide binding]; other site 903814001747 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 903814001748 carboxyltransferase (CT) interaction site; other site 903814001749 biotinylation site [posttranslational modification]; other site 903814001750 FOG: CBS domain [General function prediction only]; Region: COG0517 903814001751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 903814001752 TIGR00159 family protein; Region: TIGR00159 903814001753 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 903814001754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 903814001755 YbbR-like protein; Region: YbbR; pfam07949 903814001756 YbbR-like protein; Region: YbbR; pfam07949 903814001757 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 903814001758 homodimer interface [polypeptide binding]; other site 903814001759 substrate-cofactor binding pocket; other site 903814001760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814001761 catalytic residue [active] 903814001762 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 903814001763 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 903814001764 putative ligand binding site [chemical binding]; other site 903814001765 putative NAD binding site [chemical binding]; other site 903814001766 putative catalytic site [active] 903814001767 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 903814001768 L-serine binding site [chemical binding]; other site 903814001769 ACT domain interface; other site 903814001770 Uncharacterized conserved protein [Function unknown]; Region: COG4198 903814001771 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 903814001772 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 903814001773 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 903814001774 xanthine permease; Region: pbuX; TIGR03173 903814001775 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 903814001776 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814001777 Walker A/P-loop; other site 903814001778 ATP binding site [chemical binding]; other site 903814001779 Q-loop/lid; other site 903814001780 ABC transporter signature motif; other site 903814001781 Walker B; other site 903814001782 D-loop; other site 903814001783 H-loop/switch region; other site 903814001784 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 903814001785 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 903814001786 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 903814001787 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 903814001788 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 903814001789 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 903814001790 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 903814001791 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 903814001792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 903814001793 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814001794 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814001795 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 903814001796 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 903814001797 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 903814001798 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 903814001799 GGGtGRT protein; Region: GGGtGRT; pfam14057 903814001800 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 903814001801 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 903814001802 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 903814001803 Isochorismatase family; Region: Isochorismatase; pfam00857 903814001804 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 903814001805 catalytic triad [active] 903814001806 conserved cis-peptide bond; other site 903814001807 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 903814001808 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 903814001809 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 903814001810 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 903814001811 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 903814001812 Metal-binding active site; metal-binding site 903814001813 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814001814 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 903814001815 putative binding site residues; other site 903814001816 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 903814001817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814001818 ABC-ATPase subunit interface; other site 903814001819 dimer interface [polypeptide binding]; other site 903814001820 putative PBP binding regions; other site 903814001821 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814001822 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814001823 Walker A/P-loop; other site 903814001824 ATP binding site [chemical binding]; other site 903814001825 Q-loop/lid; other site 903814001826 ABC transporter signature motif; other site 903814001827 Walker B; other site 903814001828 D-loop; other site 903814001829 H-loop/switch region; other site 903814001830 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 903814001831 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814001832 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 903814001833 catalytic triad [active] 903814001834 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 903814001835 Protein similar to CwfJ C-terminus 1; Region: CwfJ_C_1; pfam04677 903814001836 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 903814001837 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 903814001838 Precorrin-8X methylmutase; Region: CbiC; pfam02570 903814001839 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 903814001840 homodimer interface [polypeptide binding]; other site 903814001841 active site 903814001842 SAM binding site [chemical binding]; other site 903814001843 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 903814001844 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 903814001845 active site 903814001846 putative homodimer interface [polypeptide binding]; other site 903814001847 SAM binding site [chemical binding]; other site 903814001848 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 903814001849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814001850 S-adenosylmethionine binding site [chemical binding]; other site 903814001851 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 903814001852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 903814001853 acyl-activating enzyme (AAE) consensus motif; other site 903814001854 AMP binding site [chemical binding]; other site 903814001855 active site 903814001856 CoA binding site [chemical binding]; other site 903814001857 ACT domain-containing protein [General function prediction only]; Region: COG4747 903814001858 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 903814001859 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 903814001860 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814001861 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 903814001862 intersubunit interface [polypeptide binding]; other site 903814001863 active site 903814001864 zinc binding site [ion binding]; other site 903814001865 Na+ binding site [ion binding]; other site 903814001866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814001867 DNA-binding site [nucleotide binding]; DNA binding site 903814001868 Transcriptional regulators [Transcription]; Region: FadR; COG2186 903814001869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814001870 DNA-binding site [nucleotide binding]; DNA binding site 903814001871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814001872 non-specific DNA binding site [nucleotide binding]; other site 903814001873 salt bridge; other site 903814001874 sequence-specific DNA binding site [nucleotide binding]; other site 903814001875 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 903814001876 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 903814001877 tRNA; other site 903814001878 putative tRNA binding site [nucleotide binding]; other site 903814001879 putative NADP binding site [chemical binding]; other site 903814001880 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 903814001881 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 903814001882 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 903814001883 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 903814001884 domain interfaces; other site 903814001885 active site 903814001886 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 903814001887 active site 903814001888 SAM binding site [chemical binding]; other site 903814001889 homodimer interface [polypeptide binding]; other site 903814001890 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 903814001891 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 903814001892 active site 903814001893 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 903814001894 dimer interface [polypeptide binding]; other site 903814001895 active site 903814001896 Schiff base residues; other site 903814001897 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 903814001898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 903814001899 inhibitor-cofactor binding pocket; inhibition site 903814001900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814001901 catalytic residue [active] 903814001902 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 903814001903 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 903814001904 active site 903814001905 C-terminal domain interface [polypeptide binding]; other site 903814001906 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 903814001907 active site 903814001908 N-terminal domain interface [polypeptide binding]; other site 903814001909 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 903814001910 active site 903814001911 SAM binding site [chemical binding]; other site 903814001912 homodimer interface [polypeptide binding]; other site 903814001913 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 903814001914 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 903814001915 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 903814001916 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 903814001917 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 903814001918 active site 903814001919 SAM binding site [chemical binding]; other site 903814001920 homodimer interface [polypeptide binding]; other site 903814001921 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 903814001922 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 903814001923 cobyric acid synthase; Provisional; Region: PRK00784 903814001924 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814001925 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814001926 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 903814001927 catalytic triad [active] 903814001928 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 903814001929 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 903814001930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814001931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814001932 homodimer interface [polypeptide binding]; other site 903814001933 catalytic residue [active] 903814001934 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 903814001935 homotrimer interface [polypeptide binding]; other site 903814001936 Walker A motif; other site 903814001937 GTP binding site [chemical binding]; other site 903814001938 Walker B motif; other site 903814001939 hypothetical protein; Provisional; Region: PRK05590 903814001940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814001941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814001942 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814001943 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 903814001944 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 903814001945 Predicted transcriptional regulators [Transcription]; Region: COG1733 903814001946 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 903814001947 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 903814001948 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 903814001949 TPP-binding site [chemical binding]; other site 903814001950 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 903814001951 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 903814001952 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 903814001953 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 903814001954 dimer interface [polypeptide binding]; other site 903814001955 PYR/PP interface [polypeptide binding]; other site 903814001956 TPP binding site [chemical binding]; other site 903814001957 substrate binding site [chemical binding]; other site 903814001958 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814001959 EamA-like transporter family; Region: EamA; pfam00892 903814001960 EamA-like transporter family; Region: EamA; pfam00892 903814001961 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 903814001962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814001963 Walker A motif; other site 903814001964 ATP binding site [chemical binding]; other site 903814001965 Walker B motif; other site 903814001966 arginine finger; other site 903814001967 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 903814001968 hypothetical protein; Validated; Region: PRK00153 903814001969 recombination protein RecR; Reviewed; Region: recR; PRK00076 903814001970 RecR protein; Region: RecR; pfam02132 903814001971 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 903814001972 putative active site [active] 903814001973 putative metal-binding site [ion binding]; other site 903814001974 tetramer interface [polypeptide binding]; other site 903814001975 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 903814001976 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 903814001977 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 903814001978 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 903814001979 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 903814001980 dimerization domain swap beta strand [polypeptide binding]; other site 903814001981 regulatory protein interface [polypeptide binding]; other site 903814001982 active site 903814001983 regulatory phosphorylation site [posttranslational modification]; other site 903814001984 YtxH-like protein; Region: YtxH; pfam12732 903814001985 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 903814001986 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 903814001987 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814001988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814001989 active site 903814001990 phosphorylation site [posttranslational modification] 903814001991 intermolecular recognition site; other site 903814001992 dimerization interface [polypeptide binding]; other site 903814001993 LytTr DNA-binding domain; Region: LytTR; pfam04397 903814001994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814001995 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 903814001996 ATP binding site [chemical binding]; other site 903814001997 Mg2+ binding site [ion binding]; other site 903814001998 G-X-G motif; other site 903814001999 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814002000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814002001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814002002 SnoaL-like domain; Region: SnoaL_4; pfam13577 903814002003 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 903814002004 anti sigma factor interaction site; other site 903814002005 regulatory phosphorylation site [posttranslational modification]; other site 903814002006 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 903814002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814002008 ATP binding site [chemical binding]; other site 903814002009 Mg2+ binding site [ion binding]; other site 903814002010 G-X-G motif; other site 903814002011 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 903814002012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814002013 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 903814002014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814002015 DNA binding residues [nucleotide binding] 903814002016 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 903814002017 elongation factor G; Reviewed; Region: PRK12740 903814002018 G1 box; other site 903814002019 putative GEF interaction site [polypeptide binding]; other site 903814002020 GTP/Mg2+ binding site [chemical binding]; other site 903814002021 Switch I region; other site 903814002022 G2 box; other site 903814002023 G3 box; other site 903814002024 Switch II region; other site 903814002025 G4 box; other site 903814002026 G5 box; other site 903814002027 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 903814002028 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 903814002029 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 903814002030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814002031 active site 903814002032 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 903814002033 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 903814002034 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 903814002035 active site 903814002036 HIGH motif; other site 903814002037 dimer interface [polypeptide binding]; other site 903814002038 KMSKS motif; other site 903814002039 glycerol kinase; Provisional; Region: glpK; PRK00047 903814002040 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 903814002041 N- and C-terminal domain interface [polypeptide binding]; other site 903814002042 active site 903814002043 MgATP binding site [chemical binding]; other site 903814002044 catalytic site [active] 903814002045 metal binding site [ion binding]; metal-binding site 903814002046 glycerol binding site [chemical binding]; other site 903814002047 homotetramer interface [polypeptide binding]; other site 903814002048 homodimer interface [polypeptide binding]; other site 903814002049 FBP binding site [chemical binding]; other site 903814002050 protein IIAGlc interface [polypeptide binding]; other site 903814002051 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 903814002052 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 903814002053 active site 903814002054 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 903814002055 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 903814002056 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 903814002057 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 903814002058 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 903814002059 Part of AAA domain; Region: AAA_19; pfam13245 903814002060 Family description; Region: UvrD_C_2; pfam13538 903814002061 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 903814002062 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 903814002063 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 903814002064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 903814002065 active site 903814002066 catalytic tetrad [active] 903814002067 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814002068 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 903814002069 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 903814002070 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 903814002071 active site 903814002072 metal binding site [ion binding]; metal-binding site 903814002073 DNA binding site [nucleotide binding] 903814002074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814002075 AAA domain; Region: AAA_23; pfam13476 903814002076 Walker A/P-loop; other site 903814002077 ATP binding site [chemical binding]; other site 903814002078 DRTGG domain; Region: DRTGG; pfam07085 903814002079 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 903814002080 YejG-like protein; Region: YejG; cl08201 903814002081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814002082 ATP binding site [chemical binding]; other site 903814002083 G-X-G motif; other site 903814002084 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 903814002085 4Fe-4S binding domain; Region: Fer4; pfam00037 903814002086 4Fe-4S binding domain; Region: Fer4_6; pfam12837 903814002087 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 903814002088 Putative Fe-S cluster; Region: FeS; cl17515 903814002089 DRTGG domain; Region: DRTGG; pfam07085 903814002090 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 903814002091 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 903814002092 active site 903814002093 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 903814002094 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 903814002095 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 903814002096 putative dimer interface [polypeptide binding]; other site 903814002097 [2Fe-2S] cluster binding site [ion binding]; other site 903814002098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814002099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814002100 ATP binding site [chemical binding]; other site 903814002101 Mg2+ binding site [ion binding]; other site 903814002102 G-X-G motif; other site 903814002103 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 903814002104 dimer interface [polypeptide binding]; other site 903814002105 [2Fe-2S] cluster binding site [ion binding]; other site 903814002106 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 903814002107 dimer interface [polypeptide binding]; other site 903814002108 [2Fe-2S] cluster binding site [ion binding]; other site 903814002109 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 903814002110 SLBB domain; Region: SLBB; pfam10531 903814002111 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 903814002112 4Fe-4S binding domain; Region: Fer4; pfam00037 903814002113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 903814002114 catalytic loop [active] 903814002115 iron binding site [ion binding]; other site 903814002116 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 903814002117 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 903814002118 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 903814002119 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 903814002120 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 903814002121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814002122 motif II; other site 903814002123 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 903814002124 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 903814002125 active site 903814002126 metal binding site [ion binding]; metal-binding site 903814002127 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 903814002128 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 903814002129 thiS-thiF/thiG interaction site; other site 903814002130 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 903814002131 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 903814002132 putative ATP binding site [chemical binding]; other site 903814002133 putative substrate interface [chemical binding]; other site 903814002134 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 903814002135 ThiS interaction site; other site 903814002136 putative active site [active] 903814002137 tetramer interface [polypeptide binding]; other site 903814002138 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 903814002139 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 903814002140 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 903814002141 active site 903814002142 thiamine phosphate binding site [chemical binding]; other site 903814002143 pyrophosphate binding site [ion binding]; other site 903814002144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814002145 Zn2+ binding site [ion binding]; other site 903814002146 Mg2+ binding site [ion binding]; other site 903814002147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814002148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814002149 non-specific DNA binding site [nucleotide binding]; other site 903814002150 salt bridge; other site 903814002151 sequence-specific DNA binding site [nucleotide binding]; other site 903814002152 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 903814002153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814002154 nucleotide binding site [chemical binding]; other site 903814002155 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814002156 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814002157 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814002158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814002159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814002160 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 903814002161 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 903814002162 FAD binding domain; Region: FAD_binding_4; pfam01565 903814002163 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 903814002164 Ligand Binding Site [chemical binding]; other site 903814002165 Electron transfer flavoprotein domain; Region: ETF; pfam01012 903814002166 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 903814002167 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 903814002168 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 903814002169 FAD binding domain; Region: FAD_binding_4; pfam01565 903814002170 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 903814002171 Ligand binding site [chemical binding]; other site 903814002172 Electron transfer flavoprotein domain; Region: ETF; pfam01012 903814002173 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 903814002174 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 903814002175 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 903814002176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002177 DNA-binding site [nucleotide binding]; DNA binding site 903814002178 Predicted transcriptional regulators [Transcription]; Region: COG1695 903814002179 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 903814002180 Predicted membrane protein [Function unknown]; Region: COG4709 903814002181 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 903814002182 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 903814002183 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 903814002184 CAAX protease self-immunity; Region: Abi; pfam02517 903814002185 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 903814002186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814002187 FeS/SAM binding site; other site 903814002188 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 903814002189 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 903814002190 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 903814002191 Histidine kinase; Region: His_kinase; pfam06580 903814002192 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 903814002193 ATP binding site [chemical binding]; other site 903814002194 Mg2+ binding site [ion binding]; other site 903814002195 G-X-G motif; other site 903814002196 Response regulator receiver domain; Region: Response_reg; pfam00072 903814002197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814002198 active site 903814002199 phosphorylation site [posttranslational modification] 903814002200 intermolecular recognition site; other site 903814002201 dimerization interface [polypeptide binding]; other site 903814002202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814002203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814002204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 903814002205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 903814002206 dimer interface [polypeptide binding]; other site 903814002207 active site 903814002208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 903814002209 folate binding site [chemical binding]; other site 903814002210 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 903814002211 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 903814002212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814002213 PAS fold; Region: PAS_3; pfam08447 903814002214 putative active site [active] 903814002215 heme pocket [chemical binding]; other site 903814002216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814002217 metal binding site [ion binding]; metal-binding site 903814002218 active site 903814002219 I-site; other site 903814002220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814002221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814002222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814002223 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814002224 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814002225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814002226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814002227 putative substrate translocation pore; other site 903814002228 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 903814002229 Na binding site [ion binding]; other site 903814002230 BRO family, N-terminal domain; Region: Bro-N; smart01040 903814002231 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814002232 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814002233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814002234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814002235 DNA binding residues [nucleotide binding] 903814002236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 903814002237 PAS domain; Region: PAS_9; pfam13426 903814002238 putative active site [active] 903814002239 heme pocket [chemical binding]; other site 903814002240 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 903814002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814002242 Walker A motif; other site 903814002243 ATP binding site [chemical binding]; other site 903814002244 Walker B motif; other site 903814002245 arginine finger; other site 903814002246 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814002248 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814002249 putative substrate translocation pore; other site 903814002250 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 903814002251 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814002252 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814002253 Phosphotransferase enzyme family; Region: APH; pfam01636 903814002254 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 903814002255 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 903814002256 Phosphotransferase enzyme family; Region: APH; pfam01636 903814002257 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 903814002258 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 903814002259 G1 box; other site 903814002260 GTP/Mg2+ binding site [chemical binding]; other site 903814002261 G2 box; other site 903814002262 Switch I region; other site 903814002263 G3 box; other site 903814002264 Switch II region; other site 903814002265 G4 box; other site 903814002266 G5 box; other site 903814002267 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 903814002268 putative hexamer interface [polypeptide binding]; other site 903814002269 putative hexagonal pore; other site 903814002270 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 903814002271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814002272 S-adenosylmethionine binding site [chemical binding]; other site 903814002273 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 903814002274 RNA methyltransferase, RsmE family; Region: TIGR00046 903814002275 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 903814002276 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 903814002277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 903814002278 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 903814002279 nucleotide binding site/active site [active] 903814002280 HIT family signature motif; other site 903814002281 catalytic residue [active] 903814002282 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 903814002283 catalytic residues [active] 903814002284 dimer interface [polypeptide binding]; other site 903814002285 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 903814002286 Yqey-like protein; Region: YqeY; pfam09424 903814002287 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 903814002288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814002289 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814002290 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814002291 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814002292 B12 binding site [chemical binding]; other site 903814002293 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814002294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002295 DNA-binding site [nucleotide binding]; DNA binding site 903814002296 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814002297 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814002298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002299 DNA-binding site [nucleotide binding]; DNA binding site 903814002300 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 903814002301 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814002302 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814002303 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 903814002304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814002305 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814002306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814002307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814002308 Walker A/P-loop; other site 903814002309 ATP binding site [chemical binding]; other site 903814002310 Q-loop/lid; other site 903814002311 ABC transporter signature motif; other site 903814002312 Walker B; other site 903814002313 D-loop; other site 903814002314 H-loop/switch region; other site 903814002315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814002316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814002317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814002318 Walker A/P-loop; other site 903814002319 ATP binding site [chemical binding]; other site 903814002320 Q-loop/lid; other site 903814002321 ABC transporter signature motif; other site 903814002322 Walker B; other site 903814002323 D-loop; other site 903814002324 H-loop/switch region; other site 903814002325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814002326 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814002327 metal binding site [ion binding]; metal-binding site 903814002328 active site 903814002329 I-site; other site 903814002330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814002331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814002332 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 903814002333 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 903814002334 Predicted membrane protein [Function unknown]; Region: COG1511 903814002335 DNA polymerase I; Provisional; Region: PRK05755 903814002336 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 903814002337 active site 903814002338 metal binding site 1 [ion binding]; metal-binding site 903814002339 putative 5' ssDNA interaction site; other site 903814002340 metal binding site 3; metal-binding site 903814002341 metal binding site 2 [ion binding]; metal-binding site 903814002342 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 903814002343 putative DNA binding site [nucleotide binding]; other site 903814002344 putative metal binding site [ion binding]; other site 903814002345 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 903814002346 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 903814002347 active site 903814002348 DNA binding site [nucleotide binding] 903814002349 catalytic site [active] 903814002350 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 903814002351 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 903814002352 CoA-binding site [chemical binding]; other site 903814002353 ATP-binding [chemical binding]; other site 903814002354 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 903814002355 active site 903814002356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814002357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814002358 active site 903814002359 phosphorylation site [posttranslational modification] 903814002360 intermolecular recognition site; other site 903814002361 dimerization interface [polypeptide binding]; other site 903814002362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814002363 DNA binding site [nucleotide binding] 903814002364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814002365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814002366 dimer interface [polypeptide binding]; other site 903814002367 phosphorylation site [posttranslational modification] 903814002368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814002369 ATP binding site [chemical binding]; other site 903814002370 Mg2+ binding site [ion binding]; other site 903814002371 G-X-G motif; other site 903814002372 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 903814002373 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 903814002374 active site 903814002375 NAD binding site [chemical binding]; other site 903814002376 metal binding site [ion binding]; metal-binding site 903814002377 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 903814002378 Part of AAA domain; Region: AAA_19; pfam13245 903814002379 Family description; Region: UvrD_C_2; pfam13538 903814002380 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 903814002381 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 903814002382 nucleotide binding pocket [chemical binding]; other site 903814002383 K-X-D-G motif; other site 903814002384 catalytic site [active] 903814002385 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 903814002386 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 903814002387 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 903814002388 Dimer interface [polypeptide binding]; other site 903814002389 Methyltransferase domain; Region: Methyltransf_23; pfam13489 903814002390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814002391 S-adenosylmethionine binding site [chemical binding]; other site 903814002392 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 903814002393 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 903814002394 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 903814002395 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 903814002396 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 903814002397 GatB domain; Region: GatB_Yqey; smart00845 903814002398 ribonuclease PH; Reviewed; Region: rph; PRK00173 903814002399 Ribonuclease PH; Region: RNase_PH_bact; cd11362 903814002400 hexamer interface [polypeptide binding]; other site 903814002401 active site 903814002402 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 903814002403 active site 903814002404 dimerization interface [polypeptide binding]; other site 903814002405 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 903814002406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 903814002407 active site 903814002408 metal binding site [ion binding]; metal-binding site 903814002409 homotetramer interface [polypeptide binding]; other site 903814002410 4Fe-4S binding domain; Region: Fer4_6; pfam12837 903814002411 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814002412 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 903814002413 dimer interface [polypeptide binding]; other site 903814002414 FMN binding site [chemical binding]; other site 903814002415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814002416 active site 903814002417 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 903814002418 Uncharacterized conserved protein [Function unknown]; Region: COG1915 903814002419 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 903814002420 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 903814002421 Walker A/P-loop; other site 903814002422 ATP binding site [chemical binding]; other site 903814002423 Q-loop/lid; other site 903814002424 ABC transporter signature motif; other site 903814002425 Walker B; other site 903814002426 D-loop; other site 903814002427 H-loop/switch region; other site 903814002428 NIL domain; Region: NIL; pfam09383 903814002429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814002430 dimer interface [polypeptide binding]; other site 903814002431 conserved gate region; other site 903814002432 ABC-ATPase subunit interface; other site 903814002433 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 903814002434 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 903814002435 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 903814002436 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 903814002437 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 903814002438 shikimate binding site; other site 903814002439 NAD(P) binding site [chemical binding]; other site 903814002440 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 903814002441 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 903814002442 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 903814002443 putative dimer interface [polypeptide binding]; other site 903814002444 active site pocket [active] 903814002445 putative cataytic base [active] 903814002446 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 903814002447 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 903814002448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814002449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814002450 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 903814002451 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 903814002452 putative NADH binding site [chemical binding]; other site 903814002453 putative active site [active] 903814002454 nudix motif; other site 903814002455 putative metal binding site [ion binding]; other site 903814002456 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 903814002457 L-tyrosine decarboxylase; Provisional; Region: PRK13520 903814002458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814002459 catalytic residue [active] 903814002460 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 903814002461 Cache domain; Region: Cache_1; pfam02743 903814002462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814002463 dimerization interface [polypeptide binding]; other site 903814002464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814002465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814002466 metal binding site [ion binding]; metal-binding site 903814002467 active site 903814002468 I-site; other site 903814002469 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 903814002470 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 903814002471 Cl binding site [ion binding]; other site 903814002472 oligomer interface [polypeptide binding]; other site 903814002473 Predicted membrane protein [Function unknown]; Region: COG3601 903814002474 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 903814002475 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 903814002476 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 903814002477 catalytic loop [active] 903814002478 iron binding site [ion binding]; other site 903814002479 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 903814002480 [4Fe-4S] binding site [ion binding]; other site 903814002481 molybdopterin cofactor binding site; other site 903814002482 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 903814002483 molybdopterin cofactor binding site; other site 903814002484 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 903814002485 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 903814002486 GTP binding site; other site 903814002487 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 903814002488 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 903814002489 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 903814002490 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 903814002491 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 903814002492 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814002493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814002494 non-specific DNA binding site [nucleotide binding]; other site 903814002495 salt bridge; other site 903814002496 sequence-specific DNA binding site [nucleotide binding]; other site 903814002497 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 903814002498 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814002499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814002500 sequence-specific DNA binding site [nucleotide binding]; other site 903814002501 salt bridge; other site 903814002502 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 903814002503 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 903814002504 catalytic residues [active] 903814002505 catalytic nucleophile [active] 903814002506 Recombinase; Region: Recombinase; pfam07508 903814002507 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 903814002508 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 903814002509 DNA topoisomerase III; Provisional; Region: PRK07726 903814002510 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 903814002511 active site 903814002512 putative interdomain interaction site [polypeptide binding]; other site 903814002513 putative metal-binding site [ion binding]; other site 903814002514 putative nucleotide binding site [chemical binding]; other site 903814002515 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 903814002516 domain I; other site 903814002517 DNA binding groove [nucleotide binding] 903814002518 phosphate binding site [ion binding]; other site 903814002519 domain II; other site 903814002520 domain III; other site 903814002521 nucleotide binding site [chemical binding]; other site 903814002522 catalytic site [active] 903814002523 domain IV; other site 903814002524 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 903814002525 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 903814002526 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 903814002527 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 903814002528 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 903814002529 substrate binding site [chemical binding]; other site 903814002530 dimer interface [polypeptide binding]; other site 903814002531 ATP binding site [chemical binding]; other site 903814002532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814002533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814002534 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814002535 MFS/sugar transport protein; Region: MFS_2; pfam13347 903814002536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814002537 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814002538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 903814002539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814002540 active site 903814002541 phosphorylation site [posttranslational modification] 903814002542 intermolecular recognition site; other site 903814002543 dimerization interface [polypeptide binding]; other site 903814002544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 903814002545 DNA binding residues [nucleotide binding] 903814002546 dimerization interface [polypeptide binding]; other site 903814002547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 903814002548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814002549 ATP binding site [chemical binding]; other site 903814002550 Mg2+ binding site [ion binding]; other site 903814002551 G-X-G motif; other site 903814002552 FtsX-like permease family; Region: FtsX; pfam02687 903814002553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814002554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814002555 Walker A/P-loop; other site 903814002556 ATP binding site [chemical binding]; other site 903814002557 Q-loop/lid; other site 903814002558 ABC transporter signature motif; other site 903814002559 Walker B; other site 903814002560 D-loop; other site 903814002561 H-loop/switch region; other site 903814002562 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 903814002563 pyrroline-5-carboxylate reductase; Region: PLN02688 903814002564 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 903814002565 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 903814002566 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 903814002567 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 903814002568 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 903814002569 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 903814002570 DNA binding residues [nucleotide binding] 903814002571 putative dimer interface [polypeptide binding]; other site 903814002572 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 903814002573 Glycoprotease family; Region: Peptidase_M22; pfam00814 903814002574 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 903814002575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814002576 Coenzyme A binding pocket [chemical binding]; other site 903814002577 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 903814002578 UGMP family protein; Validated; Region: PRK09604 903814002579 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 903814002580 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 903814002581 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 903814002582 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 903814002583 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 903814002584 potential catalytic triad [active] 903814002585 conserved cys residue [active] 903814002586 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 903814002587 oligomerisation interface [polypeptide binding]; other site 903814002588 mobile loop; other site 903814002589 roof hairpin; other site 903814002590 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 903814002591 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 903814002592 ring oligomerisation interface [polypeptide binding]; other site 903814002593 ATP/Mg binding site [chemical binding]; other site 903814002594 stacking interactions; other site 903814002595 hinge regions; other site 903814002596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814002598 active site 903814002599 phosphorylation site [posttranslational modification] 903814002600 intermolecular recognition site; other site 903814002601 dimerization interface [polypeptide binding]; other site 903814002602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814002603 DNA binding site [nucleotide binding] 903814002604 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 903814002605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814002606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814002607 dimer interface [polypeptide binding]; other site 903814002608 phosphorylation site [posttranslational modification] 903814002609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814002610 ATP binding site [chemical binding]; other site 903814002611 Mg2+ binding site [ion binding]; other site 903814002612 G-X-G motif; other site 903814002613 glutamate dehydrogenase; Region: PLN02477 903814002614 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 903814002615 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 903814002616 NAD(P) binding site [chemical binding]; other site 903814002617 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 903814002618 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 903814002619 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814002620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814002621 ABC transporter; Region: ABC_tran_2; pfam12848 903814002622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814002623 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 903814002624 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 903814002625 Nitrogen regulatory protein P-II; Region: P-II; smart00938 903814002626 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 903814002627 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 903814002628 CoA binding domain; Region: CoA_binding; smart00881 903814002629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 903814002630 heme pocket [chemical binding]; other site 903814002631 putative active site [active] 903814002632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814002633 PAS fold; Region: PAS_3; pfam08447 903814002634 putative active site [active] 903814002635 heme pocket [chemical binding]; other site 903814002636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814002637 metal binding site [ion binding]; metal-binding site 903814002638 active site 903814002639 I-site; other site 903814002640 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814002641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814002642 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 903814002643 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814002644 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814002645 EamA-like transporter family; Region: EamA; pfam00892 903814002646 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814002647 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814002648 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814002649 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814002650 B12 binding site [chemical binding]; other site 903814002651 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814002652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002653 DNA-binding site [nucleotide binding]; DNA binding site 903814002654 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814002655 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814002656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002657 DNA-binding site [nucleotide binding]; DNA binding site 903814002658 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 903814002659 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814002660 active site 903814002661 DNA binding site [nucleotide binding] 903814002662 Int/Topo IB signature motif; other site 903814002663 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 903814002664 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 903814002665 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 903814002666 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 903814002667 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 903814002668 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 903814002669 Catalytic site [active] 903814002670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814002671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814002672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814002673 Walker A/P-loop; other site 903814002674 ATP binding site [chemical binding]; other site 903814002675 Q-loop/lid; other site 903814002676 ABC transporter signature motif; other site 903814002677 Walker B; other site 903814002678 D-loop; other site 903814002679 H-loop/switch region; other site 903814002680 allantoinase; Region: allantoinase; TIGR03178 903814002681 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 903814002682 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 903814002683 putative active site; other site 903814002684 catalytic residue [active] 903814002685 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 903814002686 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 903814002687 DAK2 domain; Region: Dak2; pfam02734 903814002688 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814002689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814002690 DNA binding residues [nucleotide binding] 903814002691 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814002692 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 903814002693 G5 domain; Region: G5; pfam07501 903814002694 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814002695 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814002696 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814002697 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 903814002698 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814002699 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 903814002700 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 903814002701 putative substrate binding site [chemical binding]; other site 903814002702 putative ATP binding site [chemical binding]; other site 903814002703 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 903814002704 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 903814002705 active site 903814002706 phosphorylation site [posttranslational modification] 903814002707 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 903814002708 active site 903814002709 P-loop; other site 903814002710 phosphorylation site [posttranslational modification] 903814002711 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 903814002712 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 903814002713 dimerization domain swap beta strand [polypeptide binding]; other site 903814002714 regulatory protein interface [polypeptide binding]; other site 903814002715 active site 903814002716 regulatory phosphorylation site [posttranslational modification]; other site 903814002717 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 903814002718 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 903814002719 glutamine binding [chemical binding]; other site 903814002720 catalytic triad [active] 903814002721 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 903814002722 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 903814002723 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 903814002724 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 903814002725 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 903814002726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814002727 catalytic residue [active] 903814002728 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 903814002729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814002730 FeS/SAM binding site; other site 903814002731 Radical SAM superfamily; Region: Radical_SAM; pfam04055 903814002732 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 903814002733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814002734 substrate binding pocket [chemical binding]; other site 903814002735 membrane-bound complex binding site; other site 903814002736 hinge residues; other site 903814002737 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 903814002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814002739 dimer interface [polypeptide binding]; other site 903814002740 conserved gate region; other site 903814002741 putative PBP binding loops; other site 903814002742 ABC-ATPase subunit interface; other site 903814002743 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 903814002744 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 903814002745 Walker A/P-loop; other site 903814002746 ATP binding site [chemical binding]; other site 903814002747 Q-loop/lid; other site 903814002748 ABC transporter signature motif; other site 903814002749 Walker B; other site 903814002750 D-loop; other site 903814002751 H-loop/switch region; other site 903814002752 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 903814002753 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 903814002754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 903814002755 Transcriptional regulators [Transcription]; Region: GntR; COG1802 903814002756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002757 DNA-binding site [nucleotide binding]; DNA binding site 903814002758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814002759 DNA-binding site [nucleotide binding]; DNA binding site 903814002760 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 903814002761 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 903814002762 active site 903814002763 metal binding site [ion binding]; metal-binding site 903814002764 dimerization interface [polypeptide binding]; other site 903814002765 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 903814002766 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 903814002767 active site 903814002768 HIGH motif; other site 903814002769 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 903814002770 KMSKS motif; other site 903814002771 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 903814002772 tRNA binding surface [nucleotide binding]; other site 903814002773 anticodon binding site; other site 903814002774 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 903814002775 Sodium Bile acid symporter family; Region: SBF; cl17470 903814002776 hypothetical protein; Validated; Region: PRK02101 903814002777 Trp repressor protein; Region: Trp_repressor; cl17266 903814002778 aminotransferase AlaT; Validated; Region: PRK09265 903814002779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814002780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814002781 homodimer interface [polypeptide binding]; other site 903814002782 catalytic residue [active] 903814002783 PspC domain; Region: PspC; pfam04024 903814002784 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 903814002785 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 903814002786 substrate binding site; other site 903814002787 dimer interface; other site 903814002788 Integral membrane protein DUF92; Region: DUF92; pfam01940 903814002789 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 903814002790 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 903814002791 active site lid residues [active] 903814002792 substrate binding pocket [chemical binding]; other site 903814002793 catalytic residues [active] 903814002794 substrate-Mg2+ binding site; other site 903814002795 aspartate-rich region 1; other site 903814002796 aspartate-rich region 2; other site 903814002797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 903814002798 phytoene desaturase; Region: crtI_fam; TIGR02734 903814002799 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 903814002800 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 903814002801 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 903814002802 tetramer interface [polypeptide binding]; other site 903814002803 TPP-binding site [chemical binding]; other site 903814002804 heterodimer interface [polypeptide binding]; other site 903814002805 phosphorylation loop region [posttranslational modification] 903814002806 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 903814002807 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 903814002808 alpha subunit interface [polypeptide binding]; other site 903814002809 TPP binding site [chemical binding]; other site 903814002810 heterodimer interface [polypeptide binding]; other site 903814002811 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 903814002812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 903814002813 E3 interaction surface; other site 903814002814 lipoyl attachment site [posttranslational modification]; other site 903814002815 e3 binding domain; Region: E3_binding; pfam02817 903814002816 e3 binding domain; Region: E3_binding; pfam02817 903814002817 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 903814002818 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 903814002819 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 903814002820 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 903814002821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814002822 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 903814002823 hypothetical protein; Provisional; Region: PRK11770 903814002824 Domain of unknown function (DUF307); Region: DUF307; pfam03733 903814002825 Domain of unknown function (DUF307); Region: DUF307; pfam03733 903814002826 GMP synthase; Reviewed; Region: guaA; PRK00074 903814002827 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 903814002828 AMP/PPi binding site [chemical binding]; other site 903814002829 candidate oxyanion hole; other site 903814002830 catalytic triad [active] 903814002831 potential glutamine specificity residues [chemical binding]; other site 903814002832 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 903814002833 ATP Binding subdomain [chemical binding]; other site 903814002834 Ligand Binding sites [chemical binding]; other site 903814002835 Dimerization subdomain; other site 903814002836 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 903814002837 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 903814002838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814002839 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814002840 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 903814002841 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 903814002842 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 903814002843 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 903814002844 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 903814002845 active site 903814002846 catalytic tetrad [active] 903814002847 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814002848 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 903814002849 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 903814002850 putative catalytic residues [active] 903814002851 catalytic nucleophile [active] 903814002852 Recombinase; Region: Recombinase; pfam07508 903814002853 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 903814002854 No apical meristem-associated C-terminal domain; Region: NAM-associated; pfam14303 903814002855 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 903814002856 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 903814002857 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 903814002858 D5 N terminal like; Region: D5_N; cl07360 903814002859 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 903814002860 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 903814002861 CHC2 zinc finger; Region: zf-CHC2; cl17510 903814002862 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 903814002863 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 903814002864 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 903814002865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814002866 ATP binding site [chemical binding]; other site 903814002867 putative Mg++ binding site [ion binding]; other site 903814002868 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 903814002869 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 903814002870 HsdM N-terminal domain; Region: HsdM_N; pfam12161 903814002871 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 903814002872 Methyltransferase domain; Region: Methyltransf_26; pfam13659 903814002873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 903814002874 Transposase; Region: DDE_Tnp_ISL3; pfam01610 903814002875 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 903814002876 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 903814002877 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 903814002878 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 903814002879 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814002880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814002881 metal binding site [ion binding]; metal-binding site 903814002882 active site 903814002883 I-site; other site 903814002884 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814002885 TIGR03987 family protein; Region: TIGR03987 903814002886 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 903814002887 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 903814002888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 903814002889 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 903814002890 active site 903814002891 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 903814002892 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 903814002893 DNA binding site [nucleotide binding] 903814002894 AAA domain; Region: AAA_30; pfam13604 903814002895 Family description; Region: UvrD_C_2; pfam13538 903814002896 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 903814002897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814002898 active site 903814002899 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 903814002900 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 903814002901 FAD binding domain; Region: FAD_binding_4; pfam01565 903814002902 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 903814002903 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 903814002904 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 903814002905 active site 903814002906 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 903814002907 AAA domain; Region: AAA_18; pfam13238 903814002908 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 903814002909 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 903814002910 phosphate binding site [ion binding]; other site 903814002911 putative substrate binding pocket [chemical binding]; other site 903814002912 dimer interface [polypeptide binding]; other site 903814002913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 903814002914 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 903814002915 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 903814002916 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 903814002917 active site 903814002918 metal binding site [ion binding]; metal-binding site 903814002919 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 903814002920 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 903814002921 homodimer interface [polypeptide binding]; other site 903814002922 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 903814002923 active site pocket [active] 903814002924 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 903814002925 classical (c) SDRs; Region: SDR_c; cd05233 903814002926 NAD(P) binding site [chemical binding]; other site 903814002927 active site 903814002928 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814002929 LytTr DNA-binding domain; Region: LytTR; pfam04397 903814002930 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 903814002931 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002932 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002933 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002934 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002935 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002936 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002937 Oxysterol-binding protein; Region: Oxysterol_BP; pfam01237 903814002938 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002939 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002940 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002941 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002942 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002943 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002944 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002945 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002946 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814002947 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002948 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002949 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814002950 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 903814002951 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 903814002952 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 903814002953 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 903814002954 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 903814002955 active site turn [active] 903814002956 phosphorylation site [posttranslational modification] 903814002957 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 903814002958 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 903814002959 NAD binding site [chemical binding]; other site 903814002960 sugar binding site [chemical binding]; other site 903814002961 divalent metal binding site [ion binding]; other site 903814002962 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 903814002963 dimer interface [polypeptide binding]; other site 903814002964 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 903814002965 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 903814002966 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 903814002967 putative active site [active] 903814002968 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 903814002969 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 903814002970 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 903814002971 putative active site [active] 903814002972 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 903814002973 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 903814002974 active site 903814002975 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 903814002976 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 903814002977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814002978 DNA binding site [nucleotide binding] 903814002979 Int/Topo IB signature motif; other site 903814002980 active site 903814002981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814002982 Zn2+ binding site [ion binding]; other site 903814002983 Mg2+ binding site [ion binding]; other site 903814002984 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 903814002985 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814002986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814002987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 903814002988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814002989 NAD(P) binding site [chemical binding]; other site 903814002990 active site 903814002991 Bacterial transcriptional activator domain; Region: BTAD; smart01043 903814002992 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 903814002993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 903814002994 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 903814002995 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 903814002996 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 903814002997 dimerization interface [polypeptide binding]; other site 903814002998 ATP binding site [chemical binding]; other site 903814002999 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 903814003000 dimerization interface [polypeptide binding]; other site 903814003001 ATP binding site [chemical binding]; other site 903814003002 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 903814003003 putative active site [active] 903814003004 catalytic triad [active] 903814003005 AIR carboxylase; Region: AIRC; pfam00731 903814003006 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 903814003007 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 903814003008 ATP binding site [chemical binding]; other site 903814003009 active site 903814003010 substrate binding site [chemical binding]; other site 903814003011 amidophosphoribosyltransferase; Provisional; Region: PRK05793 903814003012 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 903814003013 active site 903814003014 tetramer interface [polypeptide binding]; other site 903814003015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814003016 active site 903814003017 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 903814003018 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 903814003019 dimerization interface [polypeptide binding]; other site 903814003020 putative ATP binding site [chemical binding]; other site 903814003021 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 903814003022 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 903814003023 active site 903814003024 substrate binding site [chemical binding]; other site 903814003025 cosubstrate binding site; other site 903814003026 catalytic site [active] 903814003027 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 903814003028 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 903814003029 purine monophosphate binding site [chemical binding]; other site 903814003030 dimer interface [polypeptide binding]; other site 903814003031 putative catalytic residues [active] 903814003032 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 903814003033 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 903814003034 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 903814003035 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 903814003036 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 903814003037 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 903814003038 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 903814003039 Cl- selectivity filter; other site 903814003040 Cl- binding residues [ion binding]; other site 903814003041 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 903814003042 pore gating glutamate residue; other site 903814003043 dimer interface [polypeptide binding]; other site 903814003044 CHAP domain; Region: CHAP; cl17642 903814003045 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814003046 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 903814003047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814003048 H+ Antiporter protein; Region: 2A0121; TIGR00900 903814003049 putative substrate translocation pore; other site 903814003050 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814003051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814003052 Walker A/P-loop; other site 903814003053 ATP binding site [chemical binding]; other site 903814003054 Q-loop/lid; other site 903814003055 ABC transporter signature motif; other site 903814003056 Walker B; other site 903814003057 D-loop; other site 903814003058 H-loop/switch region; other site 903814003059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814003060 dimer interface [polypeptide binding]; other site 903814003061 conserved gate region; other site 903814003062 putative PBP binding loops; other site 903814003063 ABC-ATPase subunit interface; other site 903814003064 PBP superfamily domain; Region: PBP_like_2; pfam12849 903814003065 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 903814003066 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 903814003067 dimer interface [polypeptide binding]; other site 903814003068 [2Fe-2S] cluster binding site [ion binding]; other site 903814003069 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 903814003070 4Fe-4S binding domain; Region: Fer4; pfam00037 903814003071 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 903814003072 Putative Fe-S cluster; Region: FeS; cl17515 903814003073 PAS domain S-box; Region: sensory_box; TIGR00229 903814003074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814003075 putative active site [active] 903814003076 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 903814003077 phosphodiesterase; Provisional; Region: PRK12704 903814003078 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 903814003079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814003080 Zn2+ binding site [ion binding]; other site 903814003081 Mg2+ binding site [ion binding]; other site 903814003082 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 903814003083 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 903814003084 putative active site [active] 903814003085 metal binding site [ion binding]; metal-binding site 903814003086 homodimer binding site [polypeptide binding]; other site 903814003087 aspartate aminotransferase; Provisional; Region: PRK05764 903814003088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814003089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814003090 homodimer interface [polypeptide binding]; other site 903814003091 catalytic residue [active] 903814003092 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 903814003093 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 903814003094 tetramer interface [polypeptide binding]; other site 903814003095 active site 903814003096 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 903814003097 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 903814003098 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 903814003099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814003100 dimer interface [polypeptide binding]; other site 903814003101 conserved gate region; other site 903814003102 putative PBP binding loops; other site 903814003103 ABC-ATPase subunit interface; other site 903814003104 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 903814003105 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 903814003106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814003107 dimer interface [polypeptide binding]; other site 903814003108 conserved gate region; other site 903814003109 putative PBP binding loops; other site 903814003110 ABC-ATPase subunit interface; other site 903814003111 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 903814003112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814003113 Walker A/P-loop; other site 903814003114 ATP binding site [chemical binding]; other site 903814003115 Q-loop/lid; other site 903814003116 ABC transporter signature motif; other site 903814003117 Walker B; other site 903814003118 D-loop; other site 903814003119 H-loop/switch region; other site 903814003120 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 903814003121 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 903814003122 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814003123 Walker A/P-loop; other site 903814003124 ATP binding site [chemical binding]; other site 903814003125 Q-loop/lid; other site 903814003126 ABC transporter signature motif; other site 903814003127 Walker B; other site 903814003128 D-loop; other site 903814003129 H-loop/switch region; other site 903814003130 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 903814003131 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 903814003132 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 903814003133 active site 903814003134 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814003135 FtsX-like permease family; Region: FtsX; pfam02687 903814003136 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814003137 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 903814003138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814003139 FtsX-like permease family; Region: FtsX; pfam02687 903814003140 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814003141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814003142 Walker A/P-loop; other site 903814003143 ATP binding site [chemical binding]; other site 903814003144 Q-loop/lid; other site 903814003145 ABC transporter signature motif; other site 903814003146 Walker B; other site 903814003147 D-loop; other site 903814003148 H-loop/switch region; other site 903814003149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814003150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003151 dimer interface [polypeptide binding]; other site 903814003152 phosphorylation site [posttranslational modification] 903814003153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003154 ATP binding site [chemical binding]; other site 903814003155 Mg2+ binding site [ion binding]; other site 903814003156 G-X-G motif; other site 903814003157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814003158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003159 active site 903814003160 phosphorylation site [posttranslational modification] 903814003161 intermolecular recognition site; other site 903814003162 dimerization interface [polypeptide binding]; other site 903814003163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814003164 DNA binding site [nucleotide binding] 903814003165 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 903814003166 active site 903814003167 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814003168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003169 active site 903814003170 phosphorylation site [posttranslational modification] 903814003171 intermolecular recognition site; other site 903814003172 dimerization interface [polypeptide binding]; other site 903814003173 LytTr DNA-binding domain; Region: LytTR; smart00850 903814003174 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 903814003175 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 903814003176 ATP binding site [chemical binding]; other site 903814003177 Mg2+ binding site [ion binding]; other site 903814003178 G-X-G motif; other site 903814003179 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 903814003180 putative active site [active] 903814003181 catalytic triad [active] 903814003182 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 903814003183 catalytic residues [active] 903814003184 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 903814003185 CAAX protease self-immunity; Region: Abi; pfam02517 903814003186 CAAX protease self-immunity; Region: Abi; pfam02517 903814003187 Peptidase M30; Region: Peptidase_M30; pfam10460 903814003188 Fn3 associated; Region: Fn3_assoc; pfam13287 903814003189 Fn3 associated; Region: Fn3_assoc; pfam13287 903814003190 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 903814003191 active site 903814003192 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 903814003193 active site 903814003194 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814003195 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 903814003196 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 903814003197 putative active site [active] 903814003198 catalytic triad [active] 903814003199 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 903814003200 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 903814003201 catalytic residues [active] 903814003202 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 903814003203 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 903814003204 active site 903814003205 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 903814003206 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814003207 active site 903814003208 DNA binding site [nucleotide binding] 903814003209 Int/Topo IB signature motif; other site 903814003210 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 903814003211 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814003212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814003213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814003214 DNA binding residues [nucleotide binding] 903814003215 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 903814003216 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 903814003217 catalytic residues [active] 903814003218 catalytic nucleophile [active] 903814003219 Recombinase; Region: Recombinase; pfam07508 903814003220 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 903814003221 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 903814003222 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 903814003223 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 903814003224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814003225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814003226 non-specific DNA binding site [nucleotide binding]; other site 903814003227 salt bridge; other site 903814003228 sequence-specific DNA binding site [nucleotide binding]; other site 903814003229 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 903814003230 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 903814003231 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 903814003232 Walker A motif; other site 903814003233 ATP binding site [chemical binding]; other site 903814003234 Walker B motif; other site 903814003235 CHC2 zinc finger; Region: zf-CHC2; cl17510 903814003236 Domain of unknown function (DUF927); Region: DUF927; cl12098 903814003237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 903814003238 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 903814003239 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 903814003240 Phage terminase, small subunit; Region: Terminase_4; cl01525 903814003241 Phage Terminase; Region: Terminase_1; pfam03354 903814003242 Phage portal protein; Region: Phage_portal; pfam04860 903814003243 Phage-related protein [Function unknown]; Region: COG4695; cl01923 903814003244 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 903814003245 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 903814003246 Phage capsid family; Region: Phage_capsid; pfam05065 903814003247 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 903814003248 oligomerization interface [polypeptide binding]; other site 903814003249 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 903814003250 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 903814003251 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 903814003252 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 903814003253 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 903814003254 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814003255 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814003256 Phage tail protein; Region: Sipho_tail; cl17486 903814003257 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 903814003258 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 903814003259 active site 903814003260 metal binding site [ion binding]; metal-binding site 903814003261 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814003262 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814003263 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 903814003264 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 903814003265 active site 903814003266 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 903814003267 N-acetyl-D-glucosamine binding site [chemical binding]; other site 903814003268 catalytic residue [active] 903814003269 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 903814003270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814003271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003272 Coenzyme A binding pocket [chemical binding]; other site 903814003273 KTSC domain; Region: KTSC; pfam13619 903814003274 YjzC-like protein; Region: YjzC; pfam14168 903814003275 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 903814003276 CoA-transferase family III; Region: CoA_transf_3; pfam02515 903814003277 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 903814003278 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 903814003279 active site 903814003280 Na/Ca binding site [ion binding]; other site 903814003281 catalytic site [active] 903814003282 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826 903814003283 Cl binding site [ion binding]; other site 903814003284 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 903814003285 oligomer interface [polypeptide binding]; other site 903814003286 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 903814003287 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 903814003288 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 903814003289 DsrE/DsrF-like family; Region: DrsE; cl00672 903814003290 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 903814003291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814003292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814003293 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 903814003294 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 903814003295 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 903814003296 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 903814003297 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 903814003298 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 903814003299 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 903814003300 catalytic motif [active] 903814003301 Zn binding site [ion binding]; other site 903814003302 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 903814003303 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 903814003304 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 903814003305 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 903814003306 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 903814003307 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 903814003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814003309 Walker A motif; other site 903814003310 ATP binding site [chemical binding]; other site 903814003311 Walker B motif; other site 903814003312 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814003313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 903814003314 G5 domain; Region: G5; pfam07501 903814003315 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814003316 RecX family; Region: RecX; cl00936 903814003317 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814003318 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 903814003319 putative ligand binding site [chemical binding]; other site 903814003320 putative NAD binding site [chemical binding]; other site 903814003321 catalytic site [active] 903814003322 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814003323 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 903814003324 synthetase active site [active] 903814003325 NTP binding site [chemical binding]; other site 903814003326 metal binding site [ion binding]; metal-binding site 903814003327 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 903814003328 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 903814003329 PAS fold; Region: PAS_3; pfam08447 903814003330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814003331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003332 dimer interface [polypeptide binding]; other site 903814003333 phosphorylation site [posttranslational modification] 903814003334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003335 ATP binding site [chemical binding]; other site 903814003336 Mg2+ binding site [ion binding]; other site 903814003337 G-X-G motif; other site 903814003338 Response regulator receiver domain; Region: Response_reg; pfam00072 903814003339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003340 active site 903814003341 phosphorylation site [posttranslational modification] 903814003342 intermolecular recognition site; other site 903814003343 dimerization interface [polypeptide binding]; other site 903814003344 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 903814003345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 903814003346 active site 903814003347 catalytic tetrad [active] 903814003348 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 903814003349 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 903814003350 metal binding site [ion binding]; metal-binding site 903814003351 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814003352 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 903814003353 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814003354 ribulokinase; Provisional; Region: PRK04123 903814003355 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 903814003356 N- and C-terminal domain interface [polypeptide binding]; other site 903814003357 active site 903814003358 MgATP binding site [chemical binding]; other site 903814003359 catalytic site [active] 903814003360 metal binding site [ion binding]; metal-binding site 903814003361 carbohydrate binding site [chemical binding]; other site 903814003362 homodimer interface [polypeptide binding]; other site 903814003363 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 903814003364 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 903814003365 intersubunit interface [polypeptide binding]; other site 903814003366 active site 903814003367 Zn2+ binding site [ion binding]; other site 903814003368 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 903814003369 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 903814003370 active site 903814003371 metal binding site [ion binding]; metal-binding site 903814003372 Uncharacterized conserved protein [Function unknown]; Region: COG1434 903814003373 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 903814003374 putative active site [active] 903814003375 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 903814003376 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 903814003377 DEAD_2; Region: DEAD_2; pfam06733 903814003378 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 903814003379 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 903814003380 putative ADP-ribose binding site [chemical binding]; other site 903814003381 putative active site [active] 903814003382 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 903814003383 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 903814003384 amino acid carrier protein; Region: agcS; TIGR00835 903814003385 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 903814003386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 903814003387 E3 interaction surface; other site 903814003388 lipoyl attachment site [posttranslational modification]; other site 903814003389 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 903814003390 Sel1-like repeats; Region: SEL1; smart00671 903814003391 Sel1-like repeats; Region: SEL1; smart00671 903814003392 Sel1-like repeats; Region: SEL1; smart00671 903814003393 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 903814003394 DNA-binding site [nucleotide binding]; DNA binding site 903814003395 RNA-binding motif; other site 903814003396 Flavin Reductases; Region: FlaRed; cl00801 903814003397 4Fe-4S binding domain; Region: Fer4; cl02805 903814003398 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 903814003399 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 903814003400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814003401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814003402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814003403 metal binding site [ion binding]; metal-binding site 903814003404 active site 903814003405 I-site; other site 903814003406 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814003407 Transcriptional regulators [Transcription]; Region: FadR; COG2186 903814003408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814003409 DNA-binding site [nucleotide binding]; DNA binding site 903814003410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814003411 DNA-binding site [nucleotide binding]; DNA binding site 903814003412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814003413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814003414 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814003415 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814003416 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 903814003417 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814003418 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 903814003419 Walker A/P-loop; other site 903814003420 ATP binding site [chemical binding]; other site 903814003421 Q-loop/lid; other site 903814003422 ABC transporter signature motif; other site 903814003423 Walker B; other site 903814003424 D-loop; other site 903814003425 H-loop/switch region; other site 903814003426 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 903814003427 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 903814003428 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 903814003429 inhibitor-cofactor binding pocket; inhibition site 903814003430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814003431 catalytic residue [active] 903814003432 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 903814003433 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 903814003434 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 903814003435 Ligand binding site; other site 903814003436 Putative Catalytic site; other site 903814003437 DXD motif; other site 903814003438 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 903814003439 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 903814003440 Nitroreductase family; Region: Nitroreductase; pfam00881 903814003441 FMN binding site [chemical binding]; other site 903814003442 dimer interface [polypeptide binding]; other site 903814003443 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 903814003444 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 903814003445 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 903814003446 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814003447 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 903814003448 putative ligand binding site [chemical binding]; other site 903814003449 putative NAD binding site [chemical binding]; other site 903814003450 catalytic site [active] 903814003451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814003452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003453 dimer interface [polypeptide binding]; other site 903814003454 phosphorylation site [posttranslational modification] 903814003455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003456 ATP binding site [chemical binding]; other site 903814003457 Mg2+ binding site [ion binding]; other site 903814003458 G-X-G motif; other site 903814003459 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814003460 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814003461 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814003462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814003463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814003464 Walker A/P-loop; other site 903814003465 ATP binding site [chemical binding]; other site 903814003466 Q-loop/lid; other site 903814003467 ABC transporter signature motif; other site 903814003468 Walker B; other site 903814003469 D-loop; other site 903814003470 H-loop/switch region; other site 903814003471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814003472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003473 active site 903814003474 phosphorylation site [posttranslational modification] 903814003475 intermolecular recognition site; other site 903814003476 dimerization interface [polypeptide binding]; other site 903814003477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814003478 DNA binding site [nucleotide binding] 903814003479 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 903814003480 putative deacylase active site [active] 903814003481 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 903814003482 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 903814003483 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 903814003484 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814003485 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 903814003486 non-specific DNA interactions [nucleotide binding]; other site 903814003487 DNA binding site [nucleotide binding] 903814003488 sequence specific DNA binding site [nucleotide binding]; other site 903814003489 putative cAMP binding site [chemical binding]; other site 903814003490 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814003491 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 903814003492 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814003493 nucleotide binding site [chemical binding]; other site 903814003494 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 903814003495 histidinol-phosphatase; Provisional; Region: PRK05588 903814003496 active site 903814003497 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 903814003498 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 903814003499 active site 903814003500 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 903814003501 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 903814003502 dimer interface [polypeptide binding]; other site 903814003503 putative functional site; other site 903814003504 putative MPT binding site; other site 903814003505 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 903814003506 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 903814003507 dimer interface [polypeptide binding]; other site 903814003508 putative functional site; other site 903814003509 putative MPT binding site; other site 903814003510 PBP superfamily domain; Region: PBP_like; pfam12727 903814003511 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 903814003512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814003513 FeS/SAM binding site; other site 903814003514 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 903814003515 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 903814003516 trimer interface [polypeptide binding]; other site 903814003517 dimer interface [polypeptide binding]; other site 903814003518 putative active site [active] 903814003519 MOSC domain; Region: MOSC; pfam03473 903814003520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814003521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003522 dimer interface [polypeptide binding]; other site 903814003523 phosphorylation site [posttranslational modification] 903814003524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003525 ATP binding site [chemical binding]; other site 903814003526 Mg2+ binding site [ion binding]; other site 903814003527 G-X-G motif; other site 903814003528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814003529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003530 active site 903814003531 phosphorylation site [posttranslational modification] 903814003532 intermolecular recognition site; other site 903814003533 dimerization interface [polypeptide binding]; other site 903814003534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814003535 DNA binding site [nucleotide binding] 903814003536 RelB antitoxin; Region: RelB; cl01171 903814003537 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 903814003538 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814003539 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814003540 Predicted transcriptional regulators [Transcription]; Region: COG1695 903814003541 Transcriptional regulator PadR-like family; Region: PadR; cl17335 903814003542 4Fe-4S binding domain; Region: Fer4; cl02805 903814003543 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814003544 Nitroreductase family; Region: Nitroreductase; pfam00881 903814003545 FMN binding site [chemical binding]; other site 903814003546 dimer interface [polypeptide binding]; other site 903814003547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814003548 dimerization interface [polypeptide binding]; other site 903814003549 putative DNA binding site [nucleotide binding]; other site 903814003550 putative Zn2+ binding site [ion binding]; other site 903814003551 Flavodoxin domain; Region: Flavodoxin_5; cl17428 903814003552 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814003553 LysE type translocator; Region: LysE; cl00565 903814003554 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 903814003555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814003556 non-specific DNA binding site [nucleotide binding]; other site 903814003557 salt bridge; other site 903814003558 sequence-specific DNA binding site [nucleotide binding]; other site 903814003559 Cupin domain; Region: Cupin_2; pfam07883 903814003560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003561 Coenzyme A binding pocket [chemical binding]; other site 903814003562 GTPase RsgA; Reviewed; Region: PRK01889 903814003563 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 903814003564 RNA binding site [nucleotide binding]; other site 903814003565 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 903814003566 GTPase/Zn-binding domain interface [polypeptide binding]; other site 903814003567 GTP/Mg2+ binding site [chemical binding]; other site 903814003568 G4 box; other site 903814003569 G5 box; other site 903814003570 G1 box; other site 903814003571 Switch I region; other site 903814003572 G2 box; other site 903814003573 G3 box; other site 903814003574 Switch II region; other site 903814003575 Predicted transcriptional regulators [Transcription]; Region: COG1733 903814003576 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 903814003577 Protein of unknown function DUF111; Region: DUF111; cl03398 903814003578 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 903814003579 AIR carboxylase; Region: AIRC; smart01001 903814003580 Protein of unknown function DUF111; Region: DUF111; pfam01969 903814003581 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 903814003582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003583 Coenzyme A binding pocket [chemical binding]; other site 903814003584 YoaP-like; Region: YoaP; pfam14268 903814003585 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 903814003586 hydrophobic ligand binding site; other site 903814003587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814003588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814003589 DNA binding site [nucleotide binding] 903814003590 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 903814003591 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 903814003592 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814003593 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814003594 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 903814003595 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814003596 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 903814003597 MgtC family; Region: MgtC; pfam02308 903814003598 magnesium-transporting ATPase; Provisional; Region: PRK15122 903814003599 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 903814003600 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814003601 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814003602 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814003603 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814003604 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 903814003605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814003606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814003607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 903814003608 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 903814003609 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814003610 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814003611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814003612 non-specific DNA binding site [nucleotide binding]; other site 903814003613 salt bridge; other site 903814003614 sequence-specific DNA binding site [nucleotide binding]; other site 903814003615 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814003616 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814003617 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 903814003618 homodimer interaction site [polypeptide binding]; other site 903814003619 cofactor binding site; other site 903814003620 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814003621 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 903814003622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 903814003623 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 903814003624 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814003625 DNA binding residues [nucleotide binding] 903814003626 dimer interface [polypeptide binding]; other site 903814003627 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 903814003628 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814003629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003630 Coenzyme A binding pocket [chemical binding]; other site 903814003631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003632 Coenzyme A binding pocket [chemical binding]; other site 903814003633 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 903814003634 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 903814003635 active site 903814003636 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 903814003637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814003638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003639 active site 903814003640 phosphorylation site [posttranslational modification] 903814003641 intermolecular recognition site; other site 903814003642 dimerization interface [polypeptide binding]; other site 903814003643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814003644 DNA binding site [nucleotide binding] 903814003645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814003646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003647 dimer interface [polypeptide binding]; other site 903814003648 phosphorylation site [posttranslational modification] 903814003649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003650 ATP binding site [chemical binding]; other site 903814003651 Mg2+ binding site [ion binding]; other site 903814003652 G-X-G motif; other site 903814003653 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 903814003654 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 903814003655 PAS fold; Region: PAS_3; pfam08447 903814003656 PAS domain; Region: PAS_9; pfam13426 903814003657 PAS domain S-box; Region: sensory_box; TIGR00229 903814003658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814003659 putative active site [active] 903814003660 heme pocket [chemical binding]; other site 903814003661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814003662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003663 dimer interface [polypeptide binding]; other site 903814003664 phosphorylation site [posttranslational modification] 903814003665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003666 ATP binding site [chemical binding]; other site 903814003667 G-X-G motif; other site 903814003668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 903814003669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003670 active site 903814003671 phosphorylation site [posttranslational modification] 903814003672 intermolecular recognition site; other site 903814003673 dimerization interface [polypeptide binding]; other site 903814003674 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 903814003675 Clp amino terminal domain; Region: Clp_N; pfam02861 903814003676 Clp amino terminal domain; Region: Clp_N; pfam02861 903814003677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814003678 Walker A motif; other site 903814003679 ATP binding site [chemical binding]; other site 903814003680 Walker B motif; other site 903814003681 arginine finger; other site 903814003682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814003683 Walker A motif; other site 903814003684 ATP binding site [chemical binding]; other site 903814003685 Walker B motif; other site 903814003686 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 903814003687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 903814003688 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 903814003689 V4R domain; Region: V4R; cl15268 903814003690 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814003691 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 903814003692 putative metal binding site [ion binding]; other site 903814003693 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 903814003694 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814003695 ABC-ATPase subunit interface; other site 903814003696 dimer interface [polypeptide binding]; other site 903814003697 putative PBP binding regions; other site 903814003698 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814003699 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814003700 Walker A/P-loop; other site 903814003701 ATP binding site [chemical binding]; other site 903814003702 Q-loop/lid; other site 903814003703 ABC transporter signature motif; other site 903814003704 Walker B; other site 903814003705 D-loop; other site 903814003706 H-loop/switch region; other site 903814003707 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 903814003708 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 903814003709 active site 903814003710 dimer interface [polypeptide binding]; other site 903814003711 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 903814003712 dimer interface [polypeptide binding]; other site 903814003713 active site 903814003714 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 903814003715 Na2 binding site [ion binding]; other site 903814003716 putative substrate binding site 1 [chemical binding]; other site 903814003717 Na binding site 1 [ion binding]; other site 903814003718 putative substrate binding site 2 [chemical binding]; other site 903814003719 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 903814003720 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 903814003721 Na binding site [ion binding]; other site 903814003722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814003723 MarR family; Region: MarR_2; pfam12802 903814003724 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 903814003725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 903814003726 active site 903814003727 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814003728 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 903814003729 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814003730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 903814003731 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 903814003732 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 903814003733 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 903814003734 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 903814003735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 903814003736 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814003737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 903814003738 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 903814003739 FAD binding site [chemical binding]; other site 903814003740 homotetramer interface [polypeptide binding]; other site 903814003741 substrate binding pocket [chemical binding]; other site 903814003742 catalytic base [active] 903814003743 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 903814003744 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 903814003745 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 903814003746 Rubredoxin; Region: Rubredoxin; pfam00301 903814003747 iron binding site [ion binding]; other site 903814003748 Rrf2 family protein; Region: rrf2_super; TIGR00738 903814003749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814003750 putative DNA binding site [nucleotide binding]; other site 903814003751 putative Zn2+ binding site [ion binding]; other site 903814003752 Transcriptional regulator; Region: Rrf2; cl17282 903814003753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 903814003754 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 903814003755 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 903814003756 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 903814003757 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 903814003758 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 903814003759 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 903814003760 dimer interface [polypeptide binding]; other site 903814003761 PYR/PP interface [polypeptide binding]; other site 903814003762 TPP binding site [chemical binding]; other site 903814003763 substrate binding site [chemical binding]; other site 903814003764 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 903814003765 Domain of unknown function; Region: EKR; smart00890 903814003766 4Fe-4S binding domain; Region: Fer4_6; pfam12837 903814003767 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814003768 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 903814003769 TPP-binding site [chemical binding]; other site 903814003770 dimer interface [polypeptide binding]; other site 903814003771 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 903814003772 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 903814003773 tetrameric interface [polypeptide binding]; other site 903814003774 activator binding site; other site 903814003775 NADP binding site [chemical binding]; other site 903814003776 substrate binding site [chemical binding]; other site 903814003777 catalytic residues [active] 903814003778 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 903814003779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 903814003780 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 903814003781 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 903814003782 dimerization domain swap beta strand [polypeptide binding]; other site 903814003783 regulatory protein interface [polypeptide binding]; other site 903814003784 active site 903814003785 regulatory phosphorylation site [posttranslational modification]; other site 903814003786 cobalamin synthase; Reviewed; Region: cobS; PRK00235 903814003787 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 903814003788 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 903814003789 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 903814003790 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 903814003791 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 903814003792 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 903814003793 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 903814003794 TRAM domain; Region: TRAM; pfam01938 903814003795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814003796 S-adenosylmethionine binding site [chemical binding]; other site 903814003797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 903814003798 Uncharacterized conserved protein [Function unknown]; Region: COG3586 903814003799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814003800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003801 Coenzyme A binding pocket [chemical binding]; other site 903814003802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814003803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814003804 Coenzyme A binding pocket [chemical binding]; other site 903814003805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814003806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814003807 putative substrate translocation pore; other site 903814003808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814003809 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 903814003810 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 903814003811 Part of AAA domain; Region: AAA_19; pfam13245 903814003812 Family description; Region: UvrD_C_2; pfam13538 903814003813 GAF domain; Region: GAF_3; pfam13492 903814003814 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 903814003815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814003816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814003817 metal binding site [ion binding]; metal-binding site 903814003818 active site 903814003819 I-site; other site 903814003820 PAS fold; Region: PAS_3; pfam08447 903814003821 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 903814003822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814003823 metal binding site [ion binding]; metal-binding site 903814003824 active site 903814003825 I-site; other site 903814003826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814003827 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 903814003828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814003829 S-adenosylmethionine binding site [chemical binding]; other site 903814003830 Uncharacterized conserved protein [Function unknown]; Region: COG1284 903814003831 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 903814003832 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 903814003833 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 903814003834 ApbE family; Region: ApbE; pfam02424 903814003835 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 903814003836 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 903814003837 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 903814003838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814003839 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 903814003840 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 903814003841 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 903814003842 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 903814003843 Ligand Binding Site [chemical binding]; other site 903814003844 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 903814003845 GAF domain; Region: GAF_3; pfam13492 903814003846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814003847 dimer interface [polypeptide binding]; other site 903814003848 phosphorylation site [posttranslational modification] 903814003849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814003850 ATP binding site [chemical binding]; other site 903814003851 Mg2+ binding site [ion binding]; other site 903814003852 G-X-G motif; other site 903814003853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814003854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814003855 active site 903814003856 phosphorylation site [posttranslational modification] 903814003857 intermolecular recognition site; other site 903814003858 dimerization interface [polypeptide binding]; other site 903814003859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814003860 DNA binding site [nucleotide binding] 903814003861 flavoprotein, HI0933 family; Region: TIGR00275 903814003862 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 903814003863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 903814003864 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 903814003865 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 903814003866 catalytic residue [active] 903814003867 putative FPP diphosphate binding site; other site 903814003868 putative FPP binding hydrophobic cleft; other site 903814003869 dimer interface [polypeptide binding]; other site 903814003870 putative IPP diphosphate binding site; other site 903814003871 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 903814003872 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 903814003873 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 903814003874 Peptidase family M50; Region: Peptidase_M50; pfam02163 903814003875 active site 903814003876 putative substrate binding region [chemical binding]; other site 903814003877 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 903814003878 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 903814003879 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 903814003880 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 903814003881 generic binding surface II; other site 903814003882 generic binding surface I; other site 903814003883 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 903814003884 active site 903814003885 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 903814003886 active site 903814003887 catalytic site [active] 903814003888 substrate binding site [chemical binding]; other site 903814003889 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 903814003890 active site 903814003891 putative PHP Thumb interface [polypeptide binding]; other site 903814003892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814003893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814003894 metal binding site [ion binding]; metal-binding site 903814003895 active site 903814003896 I-site; other site 903814003897 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814003898 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 903814003899 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 903814003900 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 903814003901 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 903814003902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 903814003903 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 903814003904 transcriptional regulator NanR; Provisional; Region: PRK03837 903814003905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814003906 DNA-binding site [nucleotide binding]; DNA binding site 903814003907 FCD domain; Region: FCD; pfam07729 903814003908 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 903814003909 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 903814003910 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814003911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814003912 Walker A/P-loop; other site 903814003913 ATP binding site [chemical binding]; other site 903814003914 Q-loop/lid; other site 903814003915 ABC transporter signature motif; other site 903814003916 Walker B; other site 903814003917 D-loop; other site 903814003918 H-loop/switch region; other site 903814003919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814003920 DNA-binding site [nucleotide binding]; DNA binding site 903814003921 hypothetical protein; Validated; Region: PRK08116 903814003922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814003923 Walker A motif; other site 903814003924 ATP binding site [chemical binding]; other site 903814003925 Walker B motif; other site 903814003926 arginine finger; other site 903814003927 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 903814003928 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 903814003929 dimer interface [polypeptide binding]; other site 903814003930 active site 903814003931 metal binding site [ion binding]; metal-binding site 903814003932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814003933 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 903814003934 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814003935 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 903814003936 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814003937 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 903814003938 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 903814003939 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814003940 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 903814003941 N- and C-terminal domain interface [polypeptide binding]; other site 903814003942 putative active site [active] 903814003943 MgATP binding site [chemical binding]; other site 903814003944 catalytic site [active] 903814003945 metal binding site [ion binding]; metal-binding site 903814003946 putative xylulose binding site [chemical binding]; other site 903814003947 putative homodimer interface [polypeptide binding]; other site 903814003948 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814003949 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 903814003950 B12 binding site [chemical binding]; other site 903814003951 cobalt ligand [ion binding]; other site 903814003952 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 903814003953 Glycerol kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK; cd07769 903814003954 N- and C-terminal domain interface [polypeptide binding]; other site 903814003955 active site 903814003956 MgATP binding site [chemical binding]; other site 903814003957 catalytic site [active] 903814003958 metal binding site [ion binding]; metal-binding site 903814003959 glycerol binding site [chemical binding]; other site 903814003960 homotetramer interface [polypeptide binding]; other site 903814003961 homodimer interface [polypeptide binding]; other site 903814003962 BON domain; Region: BON; pfam04972 903814003963 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814003964 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814003965 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814003966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814003967 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814003968 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 903814003969 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 903814003970 FAD binding domain; Region: FAD_binding_4; pfam01565 903814003971 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 903814003972 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 903814003973 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 903814003974 putative active site [active] 903814003975 metal binding site [ion binding]; metal-binding site 903814003976 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 903814003977 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 903814003978 active site 903814003979 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 903814003980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814003981 ABC transporter; Region: ABC_tran_2; pfam12848 903814003982 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814003983 acyl carrier protein; Provisional; Region: acpP; PRK00982 903814003984 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 903814003985 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 903814003986 carboxyltransferase (CT) interaction site; other site 903814003987 biotinylation site [posttranslational modification]; other site 903814003988 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 903814003989 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 903814003990 ATP-grasp domain; Region: ATP-grasp_4; cl17255 903814003991 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 903814003992 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 903814003993 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 903814003994 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 903814003995 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 903814003996 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 903814003997 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 903814003998 dimer interface [polypeptide binding]; other site 903814003999 active site 903814004000 CoA binding pocket [chemical binding]; other site 903814004001 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 903814004002 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 903814004003 FMN binding site [chemical binding]; other site 903814004004 substrate binding site [chemical binding]; other site 903814004005 putative catalytic residue [active] 903814004006 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 903814004007 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 903814004008 FMN binding site [chemical binding]; other site 903814004009 substrate binding site [chemical binding]; other site 903814004010 putative catalytic residue [active] 903814004011 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 903814004012 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 903814004013 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 903814004014 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 903814004015 NAD(P) binding site [chemical binding]; other site 903814004016 homotetramer interface [polypeptide binding]; other site 903814004017 homodimer interface [polypeptide binding]; other site 903814004018 active site 903814004019 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 903814004020 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 903814004021 dimer interface [polypeptide binding]; other site 903814004022 active site 903814004023 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 903814004024 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 903814004025 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 903814004026 active site 903814004027 HIGH motif; other site 903814004028 nucleotide binding site [chemical binding]; other site 903814004029 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 903814004030 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 903814004031 active site 903814004032 KMSKS motif; other site 903814004033 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 903814004034 tRNA binding surface [nucleotide binding]; other site 903814004035 anticodon binding site; other site 903814004036 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 903814004037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814004038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814004039 active site 903814004040 phosphorylation site [posttranslational modification] 903814004041 intermolecular recognition site; other site 903814004042 dimerization interface [polypeptide binding]; other site 903814004043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814004044 DNA binding site [nucleotide binding] 903814004045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814004046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814004047 dimer interface [polypeptide binding]; other site 903814004048 phosphorylation site [posttranslational modification] 903814004049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814004050 ATP binding site [chemical binding]; other site 903814004051 Mg2+ binding site [ion binding]; other site 903814004052 G-X-G motif; other site 903814004053 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 903814004054 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 903814004055 HlyD family secretion protein; Region: HlyD_3; pfam13437 903814004056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814004057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814004058 Walker A/P-loop; other site 903814004059 ATP binding site [chemical binding]; other site 903814004060 Q-loop/lid; other site 903814004061 ABC transporter signature motif; other site 903814004062 Walker B; other site 903814004063 D-loop; other site 903814004064 H-loop/switch region; other site 903814004065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814004066 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814004067 FtsX-like permease family; Region: FtsX; pfam02687 903814004068 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 903814004069 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 903814004070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814004071 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814004072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814004073 motif II; other site 903814004074 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814004075 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 903814004076 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 903814004077 Protein of unknown function (DUF975); Region: DUF975; cl10504 903814004078 Protein of unknown function (DUF975); Region: DUF975; cl10504 903814004079 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 903814004080 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 903814004081 Protein of unknown function (DUF512); Region: DUF512; pfam04459 903814004082 GTP-binding protein Der; Reviewed; Region: PRK00093 903814004083 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 903814004084 G1 box; other site 903814004085 GTP/Mg2+ binding site [chemical binding]; other site 903814004086 Switch I region; other site 903814004087 G2 box; other site 903814004088 Switch II region; other site 903814004089 G3 box; other site 903814004090 G4 box; other site 903814004091 G5 box; other site 903814004092 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 903814004093 G1 box; other site 903814004094 GTP/Mg2+ binding site [chemical binding]; other site 903814004095 Switch I region; other site 903814004096 G2 box; other site 903814004097 G3 box; other site 903814004098 Switch II region; other site 903814004099 G4 box; other site 903814004100 G5 box; other site 903814004101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 903814004102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814004103 Coenzyme A binding pocket [chemical binding]; other site 903814004104 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 903814004105 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 903814004106 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 903814004107 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814004108 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 903814004109 NAD(P) binding site [chemical binding]; other site 903814004110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814004111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814004112 active site 903814004113 phosphorylation site [posttranslational modification] 903814004114 intermolecular recognition site; other site 903814004115 dimerization interface [polypeptide binding]; other site 903814004116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814004117 DNA binding site [nucleotide binding] 903814004118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814004119 dimerization interface [polypeptide binding]; other site 903814004120 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 903814004121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814004122 putative active site [active] 903814004123 heme pocket [chemical binding]; other site 903814004124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814004125 dimer interface [polypeptide binding]; other site 903814004126 phosphorylation site [posttranslational modification] 903814004127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814004128 ATP binding site [chemical binding]; other site 903814004129 Mg2+ binding site [ion binding]; other site 903814004130 G-X-G motif; other site 903814004131 Radical SAM superfamily; Region: Radical_SAM; pfam04055 903814004132 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 903814004133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814004134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814004135 active site 903814004136 phosphorylation site [posttranslational modification] 903814004137 intermolecular recognition site; other site 903814004138 dimerization interface [polypeptide binding]; other site 903814004139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814004140 DNA binding site [nucleotide binding] 903814004141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814004142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814004143 dimer interface [polypeptide binding]; other site 903814004144 phosphorylation site [posttranslational modification] 903814004145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814004146 ATP binding site [chemical binding]; other site 903814004147 Mg2+ binding site [ion binding]; other site 903814004148 G-X-G motif; other site 903814004149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814004150 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814004151 Walker A/P-loop; other site 903814004152 ATP binding site [chemical binding]; other site 903814004153 Q-loop/lid; other site 903814004154 ABC transporter signature motif; other site 903814004155 Walker B; other site 903814004156 D-loop; other site 903814004157 H-loop/switch region; other site 903814004158 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814004159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814004160 Walker A/P-loop; other site 903814004161 ATP binding site [chemical binding]; other site 903814004162 Q-loop/lid; other site 903814004163 ABC transporter signature motif; other site 903814004164 Walker B; other site 903814004165 D-loop; other site 903814004166 H-loop/switch region; other site 903814004167 FtsX-like permease family; Region: FtsX; pfam02687 903814004168 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814004169 FtsX-like permease family; Region: FtsX; pfam02687 903814004170 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 903814004171 Ligand binding site [chemical binding]; other site 903814004172 Electron transfer flavoprotein domain; Region: ETF; pfam01012 903814004173 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 903814004174 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 903814004175 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 903814004176 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 903814004177 AAA ATPase domain; Region: AAA_16; pfam13191 903814004178 Archaeal ATPase; Region: Arch_ATPase; pfam01637 903814004179 Protein of unknown function (DUF742); Region: DUF742; pfam05331 903814004180 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 903814004181 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 903814004182 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814004183 LytTr DNA-binding domain; Region: LytTR; smart00850 903814004184 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 903814004185 active site 903814004186 catalytic triad [active] 903814004187 oxyanion hole [active] 903814004188 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 903814004189 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 903814004190 active site 903814004191 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 903814004192 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 903814004193 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 903814004194 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 903814004195 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 903814004196 glutamine binding [chemical binding]; other site 903814004197 catalytic triad [active] 903814004198 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 903814004199 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 903814004200 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 903814004201 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 903814004202 active site 903814004203 ribulose/triose binding site [chemical binding]; other site 903814004204 phosphate binding site [ion binding]; other site 903814004205 substrate (anthranilate) binding pocket [chemical binding]; other site 903814004206 product (indole) binding pocket [chemical binding]; other site 903814004207 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 903814004208 active site 903814004209 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 903814004210 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 903814004211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814004212 catalytic residue [active] 903814004213 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 903814004214 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 903814004215 substrate binding site [chemical binding]; other site 903814004216 active site 903814004217 catalytic residues [active] 903814004218 heterodimer interface [polypeptide binding]; other site 903814004219 PhosphatidylEthanolamine-Binding Protein (PEBP) domain; Region: PEBP; cl00227 903814004220 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 903814004221 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 903814004222 active site 903814004223 Malic enzyme, N-terminal domain; Region: malic; pfam00390 903814004224 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 903814004225 putative NAD(P) binding site [chemical binding]; other site 903814004226 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 903814004227 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 903814004228 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814004229 DNA binding residues [nucleotide binding] 903814004230 dimer interface [polypeptide binding]; other site 903814004231 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 903814004232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814004233 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 903814004234 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814004235 Int/Topo IB signature motif; other site 903814004236 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 903814004237 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 903814004238 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 903814004239 catalytic site [active] 903814004240 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 903814004241 active site 903814004242 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 903814004243 Protein of unknown function (DUF464); Region: DUF464; pfam04327 903814004244 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 903814004245 GTPase CgtA; Reviewed; Region: obgE; PRK12297 903814004246 GTP1/OBG; Region: GTP1_OBG; pfam01018 903814004247 Obg GTPase; Region: Obg; cd01898 903814004248 G1 box; other site 903814004249 GTP/Mg2+ binding site [chemical binding]; other site 903814004250 Switch I region; other site 903814004251 G2 box; other site 903814004252 G3 box; other site 903814004253 Switch II region; other site 903814004254 G4 box; other site 903814004255 G5 box; other site 903814004256 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 903814004257 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 903814004258 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 903814004259 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 903814004260 active site 903814004261 (T/H)XGH motif; other site 903814004262 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814004263 Zn2+ binding site [ion binding]; other site 903814004264 Mg2+ binding site [ion binding]; other site 903814004265 Oligomerisation domain; Region: Oligomerisation; pfam02410 903814004266 GTP-binding protein YchF; Reviewed; Region: PRK09601 903814004267 YchF GTPase; Region: YchF; cd01900 903814004268 G1 box; other site 903814004269 GTP/Mg2+ binding site [chemical binding]; other site 903814004270 Switch I region; other site 903814004271 G2 box; other site 903814004272 Switch II region; other site 903814004273 G3 box; other site 903814004274 G4 box; other site 903814004275 G5 box; other site 903814004276 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 903814004277 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 903814004278 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 903814004279 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 903814004280 sensor kinase CusS; Provisional; Region: PRK09835 903814004281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814004282 dimerization interface [polypeptide binding]; other site 903814004283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814004284 dimer interface [polypeptide binding]; other site 903814004285 phosphorylation site [posttranslational modification] 903814004286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814004287 ATP binding site [chemical binding]; other site 903814004288 Mg2+ binding site [ion binding]; other site 903814004289 G-X-G motif; other site 903814004290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814004291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814004292 active site 903814004293 phosphorylation site [posttranslational modification] 903814004294 intermolecular recognition site; other site 903814004295 dimerization interface [polypeptide binding]; other site 903814004296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814004297 DNA binding site [nucleotide binding] 903814004298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814004299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814004300 active site 903814004301 phosphorylation site [posttranslational modification] 903814004302 intermolecular recognition site; other site 903814004303 dimerization interface [polypeptide binding]; other site 903814004304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814004305 DNA binding site [nucleotide binding] 903814004306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814004307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814004308 dimer interface [polypeptide binding]; other site 903814004309 phosphorylation site [posttranslational modification] 903814004310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814004311 ATP binding site [chemical binding]; other site 903814004312 Mg2+ binding site [ion binding]; other site 903814004313 G-X-G motif; other site 903814004314 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 903814004315 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 903814004316 fumarate hydratase; Provisional; Region: PRK06246 903814004317 Fumarase C-terminus; Region: Fumerase_C; cl00795 903814004318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814004319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814004320 homodimer interface [polypeptide binding]; other site 903814004321 catalytic residue [active] 903814004322 Transcriptional regulators [Transcription]; Region: PurR; COG1609 903814004323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 903814004324 DNA binding site [nucleotide binding] 903814004325 domain linker motif; other site 903814004326 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 903814004327 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 903814004328 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 903814004329 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 903814004330 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 903814004331 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814004332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814004333 substrate binding pocket [chemical binding]; other site 903814004334 membrane-bound complex binding site; other site 903814004335 hinge residues; other site 903814004336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 903814004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814004338 dimer interface [polypeptide binding]; other site 903814004339 conserved gate region; other site 903814004340 putative PBP binding loops; other site 903814004341 ABC-ATPase subunit interface; other site 903814004342 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 903814004343 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 903814004344 Walker A/P-loop; other site 903814004345 ATP binding site [chemical binding]; other site 903814004346 Q-loop/lid; other site 903814004347 ABC transporter signature motif; other site 903814004348 Walker B; other site 903814004349 D-loop; other site 903814004350 H-loop/switch region; other site 903814004351 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 903814004352 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 903814004353 active site 903814004354 dimer interface [polypeptide binding]; other site 903814004355 SLBB domain; Region: SLBB; pfam10531 903814004356 comEA protein; Region: comE; TIGR01259 903814004357 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 903814004358 HTH domain; Region: HTH_11; pfam08279 903814004359 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 903814004360 FOG: CBS domain [General function prediction only]; Region: COG0517 903814004361 PEP synthetase regulatory protein; Provisional; Region: PRK05339 903814004362 pyruvate phosphate dikinase; Provisional; Region: PRK09279 903814004363 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 903814004364 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 903814004365 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 903814004366 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 903814004367 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 903814004368 putative active site [active] 903814004369 Methyltransferase domain; Region: Methyltransf_23; pfam13489 903814004370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814004371 S-adenosylmethionine binding site [chemical binding]; other site 903814004372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814004373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814004374 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 903814004375 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 903814004376 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 903814004377 active site 903814004378 catalytic site [active] 903814004379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814004380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814004381 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 903814004382 dimerization interface [polypeptide binding]; other site 903814004383 Nitrogenase subunit NifH (ATPase) [Inorganic ion transport and metabolism]; Region: NifH; COG1348 903814004384 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814004385 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 903814004386 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 903814004387 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814004388 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 903814004389 intersubunit interface [polypeptide binding]; other site 903814004390 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 903814004391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814004392 ABC-ATPase subunit interface; other site 903814004393 dimer interface [polypeptide binding]; other site 903814004394 putative PBP binding regions; other site 903814004395 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814004396 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814004397 Walker A/P-loop; other site 903814004398 ATP binding site [chemical binding]; other site 903814004399 Q-loop/lid; other site 903814004400 ABC transporter signature motif; other site 903814004401 Walker B; other site 903814004402 D-loop; other site 903814004403 H-loop/switch region; other site 903814004404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814004405 dimerization interface [polypeptide binding]; other site 903814004406 putative DNA binding site [nucleotide binding]; other site 903814004407 putative Zn2+ binding site [ion binding]; other site 903814004408 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 903814004409 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814004410 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814004411 DGC domain; Region: DGC; pfam08859 903814004412 glycine cleavage system protein H; Provisional; Region: PRK13380 903814004413 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 903814004414 lipoyl attachment site [posttranslational modification]; other site 903814004415 DGC domain; Region: DGC; cl01742 903814004416 DGC domain; Region: DGC; cl01742 903814004417 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 903814004418 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814004419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814004420 substrate binding pocket [chemical binding]; other site 903814004421 membrane-bound complex binding site; other site 903814004422 hinge residues; other site 903814004423 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 903814004424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814004425 dimer interface [polypeptide binding]; other site 903814004426 conserved gate region; other site 903814004427 putative PBP binding loops; other site 903814004428 ABC-ATPase subunit interface; other site 903814004429 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 903814004430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814004431 Walker A/P-loop; other site 903814004432 ATP binding site [chemical binding]; other site 903814004433 Q-loop/lid; other site 903814004434 ABC transporter signature motif; other site 903814004435 Walker B; other site 903814004436 D-loop; other site 903814004437 H-loop/switch region; other site 903814004438 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 903814004439 ATP-grasp domain; Region: ATP-grasp_4; cl17255 903814004440 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 903814004441 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 903814004442 4Fe-4S binding domain; Region: Fer4; pfam00037 903814004443 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 903814004444 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 903814004445 HSP70 interaction site [polypeptide binding]; other site 903814004446 Hsp70 protein; Region: HSP70; pfam00012 903814004447 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 903814004448 nucleotide binding site [chemical binding]; other site 903814004449 putative NEF/HSP70 interaction site [polypeptide binding]; other site 903814004450 SBD interface [polypeptide binding]; other site 903814004451 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 903814004452 Cadmium resistance transporter; Region: Cad; pfam03596 903814004453 Domain of unknown function (DUF336); Region: DUF336; pfam03928 903814004454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 903814004455 active site 903814004456 phosphorylation site [posttranslational modification] 903814004457 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814004458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814004459 metal binding site [ion binding]; metal-binding site 903814004460 active site 903814004461 I-site; other site 903814004462 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814004463 PAS fold; Region: PAS_3; pfam08447 903814004464 PAS domain S-box; Region: sensory_box; TIGR00229 903814004465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814004466 putative active site [active] 903814004467 heme pocket [chemical binding]; other site 903814004468 PAS domain; Region: PAS_9; pfam13426 903814004469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814004470 putative active site [active] 903814004471 heme pocket [chemical binding]; other site 903814004472 PAS fold; Region: PAS_3; pfam08447 903814004473 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814004474 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814004475 metal binding site [ion binding]; metal-binding site 903814004476 active site 903814004477 I-site; other site 903814004478 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 903814004479 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 903814004480 dimer interface [polypeptide binding]; other site 903814004481 active site 903814004482 metal binding site [ion binding]; metal-binding site 903814004483 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814004484 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 903814004485 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 903814004486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814004487 non-specific DNA binding site [nucleotide binding]; other site 903814004488 salt bridge; other site 903814004489 sequence-specific DNA binding site [nucleotide binding]; other site 903814004490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814004491 non-specific DNA binding site [nucleotide binding]; other site 903814004492 salt bridge; other site 903814004493 sequence-specific DNA binding site [nucleotide binding]; other site 903814004494 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 903814004495 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 903814004496 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 903814004497 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 903814004498 Ubiquitin-like proteins; Region: UBQ; cl00155 903814004499 charged pocket; other site 903814004500 hydrophobic patch; other site 903814004501 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 903814004502 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 903814004503 putative dimer interface [polypeptide binding]; other site 903814004504 [2Fe-2S] cluster binding site [ion binding]; other site 903814004505 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 903814004506 dimer interface [polypeptide binding]; other site 903814004507 [2Fe-2S] cluster binding site [ion binding]; other site 903814004508 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 903814004509 SLBB domain; Region: SLBB; pfam10531 903814004510 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 903814004511 4Fe-4S binding domain; Region: Fer4_6; pfam12837 903814004512 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814004513 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 903814004514 catalytic loop [active] 903814004515 iron binding site [ion binding]; other site 903814004516 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814004517 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814004518 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 903814004519 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 903814004520 dipeptidase PepV; Reviewed; Region: PRK07318 903814004521 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 903814004522 active site 903814004523 metal binding site [ion binding]; metal-binding site 903814004524 Predicted membrane protein [Function unknown]; Region: COG1297 903814004525 putative oligopeptide transporter, OPT family; Region: TIGR00733 903814004526 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 903814004527 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 903814004528 putative active site [active] 903814004529 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 903814004530 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 903814004531 ligand binding site [chemical binding]; other site 903814004532 flexible hinge region; other site 903814004533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 903814004534 putative switch regulator; other site 903814004535 non-specific DNA interactions [nucleotide binding]; other site 903814004536 DNA binding site [nucleotide binding] 903814004537 sequence specific DNA binding site [nucleotide binding]; other site 903814004538 putative cAMP binding site [chemical binding]; other site 903814004539 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814004540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814004541 active site 903814004542 phosphorylation site [posttranslational modification] 903814004543 intermolecular recognition site; other site 903814004544 dimerization interface [polypeptide binding]; other site 903814004545 LytTr DNA-binding domain; Region: LytTR; smart00850 903814004546 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 903814004547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814004548 ATP binding site [chemical binding]; other site 903814004549 Mg2+ binding site [ion binding]; other site 903814004550 G-X-G motif; other site 903814004551 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 903814004552 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 903814004553 SdpI/YhfL protein family; Region: SdpI; pfam13630 903814004554 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 903814004555 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 903814004556 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 903814004557 FAD binding pocket [chemical binding]; other site 903814004558 FAD binding motif [chemical binding]; other site 903814004559 phosphate binding motif [ion binding]; other site 903814004560 beta-alpha-beta structure motif; other site 903814004561 NAD binding pocket [chemical binding]; other site 903814004562 Iron coordination center [ion binding]; other site 903814004563 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 903814004564 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 903814004565 4Fe-4S binding domain; Region: Fer4; pfam00037 903814004566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814004567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814004568 putative substrate translocation pore; other site 903814004569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814004570 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814004571 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 903814004572 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 903814004573 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814004574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814004575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814004576 DNA binding residues [nucleotide binding] 903814004577 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814004578 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814004579 Helix-turn-helix domain; Region: HTH_17; pfam12728 903814004580 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 903814004581 DEAD-like helicases superfamily; Region: DEXDc; smart00487 903814004582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814004583 ATP binding site [chemical binding]; other site 903814004584 putative Mg++ binding site [ion binding]; other site 903814004585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814004586 nucleotide binding region [chemical binding]; other site 903814004587 ATP-binding site [chemical binding]; other site 903814004588 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 903814004589 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 903814004590 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 903814004591 RelB antitoxin; Region: RelB; cl01171 903814004592 Probable transposase; Region: OrfB_IS605; pfam01385 903814004593 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 903814004594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814004595 NAD(P) binding site [chemical binding]; other site 903814004596 active site 903814004597 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 903814004598 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 903814004599 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 903814004600 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 903814004601 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 903814004602 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 903814004603 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 903814004604 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 903814004605 catalytic residue [active] 903814004606 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814004607 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 903814004608 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 903814004609 homodimer interface [polypeptide binding]; other site 903814004610 substrate-cofactor binding pocket; other site 903814004611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814004612 catalytic residue [active] 903814004613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 903814004614 active site 903814004615 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 903814004616 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 903814004617 trimer interface [polypeptide binding]; other site 903814004618 active site 903814004619 substrate binding site [chemical binding]; other site 903814004620 CoA binding site [chemical binding]; other site 903814004621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 903814004622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 903814004623 active site 903814004624 Protein of unknown function (DUF616); Region: DUF616; pfam04765 903814004625 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 903814004626 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 903814004627 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 903814004628 PemK-like protein; Region: PemK; pfam02452 903814004629 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 903814004630 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 903814004631 YcfA-like protein; Region: YcfA; cl00752 903814004632 PemK-like protein; Region: PemK; cl00995 903814004633 PA14 domain; Region: PA14; cl08459 903814004634 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 903814004635 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 903814004636 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004637 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 903814004638 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 903814004639 active site 903814004640 catalytic site [active] 903814004641 Transposase IS200 like; Region: Y1_Tnp; cl00848 903814004642 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814004643 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814004644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814004645 Walker A/P-loop; other site 903814004646 ATP binding site [chemical binding]; other site 903814004647 Q-loop/lid; other site 903814004648 ABC transporter signature motif; other site 903814004649 Walker B; other site 903814004650 D-loop; other site 903814004651 H-loop/switch region; other site 903814004652 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814004653 intersubunit interface [polypeptide binding]; other site 903814004654 active site 903814004655 catalytic residue [active] 903814004656 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 903814004657 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 903814004658 inhibitor site; inhibition site 903814004659 active site 903814004660 dimer interface [polypeptide binding]; other site 903814004661 catalytic residue [active] 903814004662 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814004663 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 903814004664 N- and C-terminal domain interface [polypeptide binding]; other site 903814004665 active site 903814004666 MgATP binding site [chemical binding]; other site 903814004667 catalytic site [active] 903814004668 metal binding site [ion binding]; metal-binding site 903814004669 xylulose binding site [chemical binding]; other site 903814004670 putative homodimer interface [polypeptide binding]; other site 903814004671 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 903814004672 classical (c) SDRs; Region: SDR_c; cd05233 903814004673 NAD(P) binding site [chemical binding]; other site 903814004674 active site 903814004675 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 903814004676 DNA-binding site [nucleotide binding]; DNA binding site 903814004677 RNA-binding motif; other site 903814004678 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814004679 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 903814004680 N- and C-terminal domain interface [polypeptide binding]; other site 903814004681 putative active site [active] 903814004682 MgATP binding site [chemical binding]; other site 903814004683 catalytic site [active] 903814004684 metal binding site [ion binding]; metal-binding site 903814004685 putative xylulose binding site [chemical binding]; other site 903814004686 putative homodimer interface [polypeptide binding]; other site 903814004687 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 903814004688 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814004689 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814004690 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814004691 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814004692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814004693 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 903814004694 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 903814004695 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 903814004696 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814004697 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 903814004698 active site 903814004699 NAD binding site [chemical binding]; other site 903814004700 metal binding site [ion binding]; metal-binding site 903814004701 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814004702 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 903814004703 N- and C-terminal domain interface [polypeptide binding]; other site 903814004704 putative active site [active] 903814004705 MgATP binding site [chemical binding]; other site 903814004706 catalytic site [active] 903814004707 metal binding site [ion binding]; metal-binding site 903814004708 putative xylulose binding site [chemical binding]; other site 903814004709 putative homodimer interface [polypeptide binding]; other site 903814004710 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 903814004711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814004712 active site 903814004713 motif I; other site 903814004714 motif II; other site 903814004715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814004716 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814004717 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 903814004718 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814004719 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 903814004720 ParB-like nuclease domain; Region: ParB; smart00470 903814004721 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 903814004722 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 903814004723 Active Sites [active] 903814004724 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 903814004725 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 903814004726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814004727 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 903814004728 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 903814004729 active site 903814004730 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 903814004731 multiple promoter invertase; Provisional; Region: mpi; PRK13413 903814004732 catalytic residues [active] 903814004733 catalytic nucleophile [active] 903814004734 Presynaptic Site I dimer interface [polypeptide binding]; other site 903814004735 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 903814004736 Synaptic Flat tetramer interface [polypeptide binding]; other site 903814004737 Synaptic Site I dimer interface [polypeptide binding]; other site 903814004738 DNA binding site [nucleotide binding] 903814004739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814004740 non-specific DNA binding site [nucleotide binding]; other site 903814004741 salt bridge; other site 903814004742 sequence-specific DNA binding site [nucleotide binding]; other site 903814004743 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 903814004744 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814004745 P-loop; other site 903814004746 Magnesium ion binding site [ion binding]; other site 903814004747 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814004748 Magnesium ion binding site [ion binding]; other site 903814004749 ParB-like nuclease domain; Region: ParB; smart00470 903814004750 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 903814004751 phosphodiesterase; Provisional; Region: PRK12704 903814004752 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 903814004753 Toprim-like; Region: Toprim_2; pfam13155 903814004754 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 903814004755 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 903814004756 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 903814004757 phosphate binding site [ion binding]; other site 903814004758 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 903814004759 PRD domain; Region: PRD; pfam00874 903814004760 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 903814004761 active site 903814004762 P-loop; other site 903814004763 phosphorylation site [posttranslational modification] 903814004764 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 903814004765 active site 903814004766 phosphorylation site [posttranslational modification] 903814004767 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 903814004768 active site 903814004769 phosphorylation site [posttranslational modification] 903814004770 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 903814004771 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 903814004772 oligomer interface [polypeptide binding]; other site 903814004773 active site 903814004774 metal binding site [ion binding]; metal-binding site 903814004775 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 903814004776 active site 903814004777 P-loop; other site 903814004778 phosphorylation site [posttranslational modification] 903814004779 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 903814004780 BtpA family; Region: BtpA; cl00440 903814004781 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814004782 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 903814004783 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004784 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004785 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004786 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004787 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004788 Cna protein B-type domain; Region: Cna_B; pfam05738 903814004789 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 903814004790 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 903814004791 active site 903814004792 catalytic site [active] 903814004793 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 903814004794 active site 903814004795 GIY-YIG motif/motif A; other site 903814004796 catalytic site [active] 903814004797 HipA-like C-terminal domain; Region: HipA_C; pfam07804 903814004798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 903814004799 Catalytic domain of Protein Kinases; Region: PKc; cd00180 903814004800 active site 903814004801 ATP binding site [chemical binding]; other site 903814004802 substrate binding site [chemical binding]; other site 903814004803 activation loop (A-loop); other site 903814004804 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 903814004805 Tetratricopeptide repeat; Region: TPR_16; pfam13432 903814004806 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 903814004807 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 903814004808 phosphopeptide binding site; other site 903814004809 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 903814004810 active site 903814004811 Fic family protein [Function unknown]; Region: COG3177 903814004812 Fic/DOC family; Region: Fic; pfam02661 903814004813 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 903814004814 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 903814004815 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 903814004816 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 903814004817 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 903814004818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814004819 S-adenosylmethionine binding site [chemical binding]; other site 903814004820 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 903814004821 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 903814004822 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 903814004823 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 903814004824 helicase superfamily c-terminal domain; Region: HELICc; smart00490 903814004825 HipA-like C-terminal domain; Region: HipA_C; pfam07804 903814004826 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 903814004827 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814004828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814004829 non-specific DNA binding site [nucleotide binding]; other site 903814004830 salt bridge; other site 903814004831 sequence-specific DNA binding site [nucleotide binding]; other site 903814004832 DNA topoisomerase III; Provisional; Region: PRK07726 903814004833 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 903814004834 active site 903814004835 putative interdomain interaction site [polypeptide binding]; other site 903814004836 putative metal-binding site [ion binding]; other site 903814004837 putative nucleotide binding site [chemical binding]; other site 903814004838 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 903814004839 domain I; other site 903814004840 DNA binding groove [nucleotide binding] 903814004841 phosphate binding site [ion binding]; other site 903814004842 domain II; other site 903814004843 domain III; other site 903814004844 nucleotide binding site [chemical binding]; other site 903814004845 catalytic site [active] 903814004846 domain IV; other site 903814004847 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 903814004848 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 903814004849 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 903814004850 active site 903814004851 NTP binding site [chemical binding]; other site 903814004852 metal binding triad [ion binding]; metal-binding site 903814004853 antibiotic binding site [chemical binding]; other site 903814004854 Protein of unknown function DUF86; Region: DUF86; cl01031 903814004855 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 903814004856 generic binding surface II; other site 903814004857 generic binding surface I; other site 903814004858 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 903814004859 AAA-like domain; Region: AAA_10; pfam12846 903814004860 Walker A motif; other site 903814004861 ATP binding site [chemical binding]; other site 903814004862 Walker B motif; other site 903814004863 AAA-like domain; Region: AAA_10; pfam12846 903814004864 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814004865 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814004866 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 903814004867 N-acetyl-D-glucosamine binding site [chemical binding]; other site 903814004868 catalytic residue [active] 903814004869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 903814004870 Fic/DOC family; Region: Fic; pfam02661 903814004871 Helix-turn-helix domain; Region: HTH_17; pfam12728 903814004872 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 903814004873 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814004874 Int/Topo IB signature motif; other site 903814004875 hybrid cluster protein; Provisional; Region: PRK05290 903814004876 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814004877 CODH interaction site; other site 903814004878 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 903814004879 hybrid metal cluster; other site 903814004880 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814004881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814004882 DNA-binding site [nucleotide binding]; DNA binding site 903814004883 UTRA domain; Region: UTRA; pfam07702 903814004884 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814004885 intersubunit interface [polypeptide binding]; other site 903814004886 active site 903814004887 catalytic residue [active] 903814004888 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814004889 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 903814004890 N- and C-terminal domain interface [polypeptide binding]; other site 903814004891 active site 903814004892 MgATP binding site [chemical binding]; other site 903814004893 catalytic site [active] 903814004894 metal binding site [ion binding]; metal-binding site 903814004895 xylulose binding site [chemical binding]; other site 903814004896 putative homodimer interface [polypeptide binding]; other site 903814004897 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 903814004898 putative deacylase active site [active] 903814004899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814004900 S-adenosylmethionine binding site [chemical binding]; other site 903814004901 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 903814004902 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 903814004903 AzlC protein; Region: AzlC; cl00570 903814004904 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 903814004905 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814004906 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814004907 Walker A/P-loop; other site 903814004908 ATP binding site [chemical binding]; other site 903814004909 Q-loop/lid; other site 903814004910 ABC transporter signature motif; other site 903814004911 Walker B; other site 903814004912 D-loop; other site 903814004913 H-loop/switch region; other site 903814004914 Transcriptional regulators [Transcription]; Region: FadR; COG2186 903814004915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814004916 DNA-binding site [nucleotide binding]; DNA binding site 903814004917 FCD domain; Region: FCD; pfam07729 903814004918 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 903814004919 Ligand binding site [chemical binding]; other site 903814004920 Electron transfer flavoprotein domain; Region: ETF; pfam01012 903814004921 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 903814004922 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 903814004923 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 903814004924 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 903814004925 FAD binding domain; Region: FAD_binding_4; pfam01565 903814004926 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 903814004927 L-lactate permease; Region: Lactate_perm; cl00701 903814004928 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 903814004929 TrkA-N domain; Region: TrkA_N; pfam02254 903814004930 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 903814004931 dihydrodipicolinate synthase; Region: dapA; TIGR00674 903814004932 dimer interface [polypeptide binding]; other site 903814004933 active site 903814004934 catalytic residue [active] 903814004935 Uncharacterized conserved protein [Function unknown]; Region: COG5646 903814004936 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 903814004937 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 903814004938 Catalytic site [active] 903814004939 alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090 903814004940 alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090 903814004941 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814004942 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 903814004943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814004944 NAD(P) binding site [chemical binding]; other site 903814004945 active site 903814004946 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 903814004947 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 903814004948 putative metal binding site; other site 903814004949 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814004950 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 903814004951 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814004952 putative ADP-binding pocket [chemical binding]; other site 903814004953 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 903814004954 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 903814004955 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814004956 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814004957 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 903814004958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 903814004959 active site 903814004960 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 903814004961 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 903814004962 WxcM-like, C-terminal; Region: FdtA; pfam05523 903814004963 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 903814004964 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 903814004965 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 903814004966 inhibitor-cofactor binding pocket; inhibition site 903814004967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814004968 catalytic residue [active] 903814004969 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 903814004970 putative trimer interface [polypeptide binding]; other site 903814004971 putative CoA binding site [chemical binding]; other site 903814004972 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 903814004973 putative trimer interface [polypeptide binding]; other site 903814004974 putative active site [active] 903814004975 putative substrate binding site [chemical binding]; other site 903814004976 putative CoA binding site [chemical binding]; other site 903814004977 BRO family, N-terminal domain; Region: Bro-N; smart01040 903814004978 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814004979 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814004980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814004981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814004982 DNA binding residues [nucleotide binding] 903814004983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814004984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814004985 Coenzyme A binding pocket [chemical binding]; other site 903814004986 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814004987 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814004988 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 903814004989 putative FMN binding site [chemical binding]; other site 903814004990 Sensory domain found in PocR; Region: PocR; pfam10114 903814004991 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 903814004992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814004993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814004994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814004995 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814004996 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 903814004997 B12 binding site [chemical binding]; other site 903814004998 cobalt ligand [ion binding]; other site 903814004999 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814005000 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814005001 Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176 903814005002 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814005003 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 903814005004 B12 binding site [chemical binding]; other site 903814005005 cobalt ligand [ion binding]; other site 903814005006 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 903814005007 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814005008 substrate binding pocket [chemical binding]; other site 903814005009 dimer interface [polypeptide binding]; other site 903814005010 inhibitor binding site; inhibition site 903814005011 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814005012 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814005013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814005014 metal binding site [ion binding]; metal-binding site 903814005015 active site 903814005016 I-site; other site 903814005017 RNA polymerase sigma-W factor; Region: SigW_bacill; TIGR02948 903814005018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814005019 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 903814005020 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 903814005021 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814005022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005023 active site 903814005024 phosphorylation site [posttranslational modification] 903814005025 intermolecular recognition site; other site 903814005026 dimerization interface [polypeptide binding]; other site 903814005027 LytTr DNA-binding domain; Region: LytTR; pfam04397 903814005028 Ion transport protein; Region: Ion_trans; pfam00520 903814005029 Ion channel; Region: Ion_trans_2; pfam07885 903814005030 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 903814005031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 903814005032 ATP binding site [chemical binding]; other site 903814005033 Mg2+ binding site [ion binding]; other site 903814005034 G-X-G motif; other site 903814005035 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 903814005036 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814005037 Int/Topo IB signature motif; other site 903814005038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814005039 Zn2+ binding site [ion binding]; other site 903814005040 Mg2+ binding site [ion binding]; other site 903814005041 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814005042 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814005043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814005044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814005045 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 903814005046 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 903814005047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 903814005048 Propionate catabolism activator; Region: PrpR_N; pfam06506 903814005049 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 903814005050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814005051 Walker A motif; other site 903814005052 ATP binding site [chemical binding]; other site 903814005053 Walker B motif; other site 903814005054 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 903814005055 Putative cyclase; Region: Cyclase; pfam04199 903814005056 hypothetical protein; Provisional; Region: PRK03881 903814005057 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 903814005058 AMMECR1; Region: AMMECR1; pfam01871 903814005059 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 903814005060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814005061 FeS/SAM binding site; other site 903814005062 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 903814005063 active site 903814005064 metal binding site [ion binding]; metal-binding site 903814005065 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814005066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814005067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814005068 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 903814005069 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 903814005070 A new structural DNA glycosylase; Region: AlkD_like; cd06561 903814005071 active site 903814005072 DNA primase; Validated; Region: dnaG; PRK05667 903814005073 CHC2 zinc finger; Region: zf-CHC2; pfam01807 903814005074 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 903814005075 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 903814005076 active site 903814005077 metal binding site [ion binding]; metal-binding site 903814005078 interdomain interaction site; other site 903814005079 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 903814005080 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 903814005081 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 903814005082 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 903814005083 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 903814005084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814005085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 903814005086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814005087 DNA binding residues [nucleotide binding] 903814005088 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 903814005089 Family of unknown function (DUF633); Region: DUF633; pfam04816 903814005090 Uncharacterized conserved protein [Function unknown]; Region: COG0327 903814005091 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 903814005092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 903814005093 Uncharacterized conserved protein [Function unknown]; Region: COG0327 903814005094 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 903814005095 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 903814005096 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 903814005097 NAD binding site [chemical binding]; other site 903814005098 homodimer interface [polypeptide binding]; other site 903814005099 active site 903814005100 substrate binding site [chemical binding]; other site 903814005101 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 903814005102 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 903814005103 dimer interface [polypeptide binding]; other site 903814005104 PYR/PP interface [polypeptide binding]; other site 903814005105 TPP binding site [chemical binding]; other site 903814005106 substrate binding site [chemical binding]; other site 903814005107 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 903814005108 TPP-binding site; other site 903814005109 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 903814005110 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 903814005111 Cysteine-rich small domain; Region: zf-like; cl00946 903814005112 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 903814005113 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 903814005114 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 903814005115 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 903814005116 active site 903814005117 dimer interface [polypeptide binding]; other site 903814005118 effector binding site; other site 903814005119 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 903814005120 TSCPD domain; Region: TSCPD; pfam12637 903814005121 CsbD-like; Region: CsbD; pfam05532 903814005122 gamma-glutamyl kinase; Provisional; Region: PRK05429 903814005123 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 903814005124 nucleotide binding site [chemical binding]; other site 903814005125 homotetrameric interface [polypeptide binding]; other site 903814005126 putative phosphate binding site [ion binding]; other site 903814005127 putative allosteric binding site; other site 903814005128 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 903814005129 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 903814005130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814005131 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 903814005132 16S/18S rRNA binding site [nucleotide binding]; other site 903814005133 S13e-L30e interaction site [polypeptide binding]; other site 903814005134 25S rRNA binding site [nucleotide binding]; other site 903814005135 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 903814005136 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 903814005137 RNase E interface [polypeptide binding]; other site 903814005138 trimer interface [polypeptide binding]; other site 903814005139 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 903814005140 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 903814005141 RNase E interface [polypeptide binding]; other site 903814005142 trimer interface [polypeptide binding]; other site 903814005143 active site 903814005144 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 903814005145 putative nucleic acid binding region [nucleotide binding]; other site 903814005146 G-X-X-G motif; other site 903814005147 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 903814005148 RNA binding site [nucleotide binding]; other site 903814005149 domain interface; other site 903814005150 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 903814005151 trimer interface [polypeptide binding]; other site 903814005152 active site 903814005153 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 903814005154 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 903814005155 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 903814005156 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 903814005157 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 903814005158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814005159 FeS/SAM binding site; other site 903814005160 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 903814005161 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 903814005162 competence damage-inducible protein A; Provisional; Region: PRK00549 903814005163 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 903814005164 putative MPT binding site; other site 903814005165 Competence-damaged protein; Region: CinA; pfam02464 903814005166 recombinase A; Provisional; Region: recA; PRK09354 903814005167 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 903814005168 hexamer interface [polypeptide binding]; other site 903814005169 Walker A motif; other site 903814005170 ATP binding site [chemical binding]; other site 903814005171 Walker B motif; other site 903814005172 DNA polymerase IV; Reviewed; Region: PRK03103 903814005173 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 903814005174 active site 903814005175 DNA binding site [nucleotide binding] 903814005176 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 903814005177 amphipathic channel; other site 903814005178 Asn-Pro-Ala signature motifs; other site 903814005179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 903814005180 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 903814005181 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 903814005182 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 903814005183 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 903814005184 protein binding site [polypeptide binding]; other site 903814005185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814005186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005187 active site 903814005188 phosphorylation site [posttranslational modification] 903814005189 intermolecular recognition site; other site 903814005190 dimerization interface [polypeptide binding]; other site 903814005191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814005192 DNA binding site [nucleotide binding] 903814005193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814005194 HAMP domain; Region: HAMP; pfam00672 903814005195 dimerization interface [polypeptide binding]; other site 903814005196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005197 dimer interface [polypeptide binding]; other site 903814005198 phosphorylation site [posttranslational modification] 903814005199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005200 ATP binding site [chemical binding]; other site 903814005201 Mg2+ binding site [ion binding]; other site 903814005202 G-X-G motif; other site 903814005203 inner membrane transport permease; Provisional; Region: PRK15066 903814005204 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 903814005205 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005206 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814005207 Walker A/P-loop; other site 903814005208 ATP binding site [chemical binding]; other site 903814005209 Q-loop/lid; other site 903814005210 ABC transporter signature motif; other site 903814005211 Walker B; other site 903814005212 D-loop; other site 903814005213 H-loop/switch region; other site 903814005214 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 903814005215 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 903814005216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005217 active site 903814005218 phosphorylation site [posttranslational modification] 903814005219 intermolecular recognition site; other site 903814005220 dimerization interface [polypeptide binding]; other site 903814005221 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814005222 Zn2+ binding site [ion binding]; other site 903814005223 Mg2+ binding site [ion binding]; other site 903814005224 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814005225 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814005226 metal binding site [ion binding]; metal-binding site 903814005227 active site 903814005228 I-site; other site 903814005229 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 903814005230 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 903814005231 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 903814005232 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 903814005233 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 903814005234 GAF domain; Region: GAF; cl17456 903814005235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814005236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814005237 metal binding site [ion binding]; metal-binding site 903814005238 active site 903814005239 I-site; other site 903814005240 Predicted membrane protein [Function unknown]; Region: COG1511 903814005241 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 903814005242 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 903814005243 Predicted membrane protein [Function unknown]; Region: COG1511 903814005244 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 903814005245 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 903814005246 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 903814005247 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 903814005248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005249 dimer interface [polypeptide binding]; other site 903814005250 phosphorylation site [posttranslational modification] 903814005251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005252 ATP binding site [chemical binding]; other site 903814005253 Mg2+ binding site [ion binding]; other site 903814005254 G-X-G motif; other site 903814005255 Response regulator receiver domain; Region: Response_reg; pfam00072 903814005256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005257 active site 903814005258 phosphorylation site [posttranslational modification] 903814005259 intermolecular recognition site; other site 903814005260 dimerization interface [polypeptide binding]; other site 903814005261 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814005262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814005263 DNA-binding site [nucleotide binding]; DNA binding site 903814005264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814005265 DNA-binding site [nucleotide binding]; DNA binding site 903814005266 Lysine efflux permease [General function prediction only]; Region: COG1279 903814005267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814005268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814005269 non-specific DNA binding site [nucleotide binding]; other site 903814005270 salt bridge; other site 903814005271 sequence-specific DNA binding site [nucleotide binding]; other site 903814005272 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 903814005273 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 903814005274 trimer interface [polypeptide binding]; other site 903814005275 active site 903814005276 substrate binding site [chemical binding]; other site 903814005277 CoA binding site [chemical binding]; other site 903814005278 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 903814005279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814005280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814005281 Coenzyme A binding pocket [chemical binding]; other site 903814005282 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 903814005283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 903814005284 minor groove reading motif; other site 903814005285 helix-hairpin-helix signature motif; other site 903814005286 substrate binding pocket [chemical binding]; other site 903814005287 active site 903814005288 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 903814005289 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 903814005290 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 903814005291 DNA binding site [nucleotide binding] 903814005292 active site 903814005293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814005294 Coenzyme A binding pocket [chemical binding]; other site 903814005295 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 903814005296 Methyltransferase domain; Region: Methyltransf_31; pfam13847 903814005297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814005298 S-adenosylmethionine binding site [chemical binding]; other site 903814005299 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 903814005300 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 903814005301 nudix motif; other site 903814005302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814005303 Coenzyme A binding pocket [chemical binding]; other site 903814005304 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814005305 EamA-like transporter family; Region: EamA; pfam00892 903814005306 EamA-like transporter family; Region: EamA; pfam00892 903814005307 TIGR04076 family protein; Region: TIGR04076 903814005308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814005309 non-specific DNA binding site [nucleotide binding]; other site 903814005310 salt bridge; other site 903814005311 sequence-specific DNA binding site [nucleotide binding]; other site 903814005312 CGNR zinc finger; Region: zf-CGNR; pfam11706 903814005313 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814005314 EamA-like transporter family; Region: EamA; pfam00892 903814005315 EamA-like transporter family; Region: EamA; pfam00892 903814005316 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 903814005317 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814005318 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814005319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814005320 non-specific DNA binding site [nucleotide binding]; other site 903814005321 salt bridge; other site 903814005322 sequence-specific DNA binding site [nucleotide binding]; other site 903814005323 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814005324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814005325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814005326 DNA binding residues [nucleotide binding] 903814005327 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005328 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 903814005329 Walker A/P-loop; other site 903814005330 ATP binding site [chemical binding]; other site 903814005331 Q-loop/lid; other site 903814005332 ABC transporter signature motif; other site 903814005333 Walker B; other site 903814005334 D-loop; other site 903814005335 H-loop/switch region; other site 903814005336 Uncharacterized conserved protein [Function unknown]; Region: COG0432 903814005337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814005338 non-specific DNA binding site [nucleotide binding]; other site 903814005339 salt bridge; other site 903814005340 sequence-specific DNA binding site [nucleotide binding]; other site 903814005341 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 903814005342 Catalytic site [active] 903814005343 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 903814005344 Protein of unknown function; Region: DUF3658; pfam12395 903814005345 Predicted amidohydrolase [General function prediction only]; Region: COG0388 903814005346 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 903814005347 putative active site [active] 903814005348 catalytic triad [active] 903814005349 dimer interface [polypeptide binding]; other site 903814005350 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814005351 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 903814005352 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814005353 putative active site [active] 903814005354 MgATP binding site [chemical binding]; other site 903814005355 catalytic site [active] 903814005356 metal binding site [ion binding]; metal-binding site 903814005357 putative carbohydrate binding site [chemical binding]; other site 903814005358 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 903814005359 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 903814005360 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 903814005361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 903814005362 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 903814005363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 903814005364 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 903814005365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814005366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814005367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814005368 Walker A/P-loop; other site 903814005369 ATP binding site [chemical binding]; other site 903814005370 Q-loop/lid; other site 903814005371 ABC transporter signature motif; other site 903814005372 Walker B; other site 903814005373 D-loop; other site 903814005374 H-loop/switch region; other site 903814005375 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814005376 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814005377 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814005378 Walker A/P-loop; other site 903814005379 ATP binding site [chemical binding]; other site 903814005380 Q-loop/lid; other site 903814005381 ABC transporter signature motif; other site 903814005382 Walker B; other site 903814005383 D-loop; other site 903814005384 H-loop/switch region; other site 903814005385 AAA ATPase domain; Region: AAA_16; pfam13191 903814005386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 903814005387 DNA binding residues [nucleotide binding] 903814005388 dimerization interface [polypeptide binding]; other site 903814005389 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 903814005390 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 903814005391 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 903814005392 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 903814005393 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814005394 B12 binding site [chemical binding]; other site 903814005395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814005396 FeS/SAM binding site; other site 903814005397 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 903814005398 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 903814005399 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814005400 FtsX-like permease family; Region: FtsX; pfam02687 903814005401 FtsX-like permease family; Region: FtsX; pfam02687 903814005402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814005403 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814005404 Walker A/P-loop; other site 903814005405 ATP binding site [chemical binding]; other site 903814005406 Q-loop/lid; other site 903814005407 ABC transporter signature motif; other site 903814005408 Walker B; other site 903814005409 D-loop; other site 903814005410 H-loop/switch region; other site 903814005411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814005412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005413 active site 903814005414 phosphorylation site [posttranslational modification] 903814005415 intermolecular recognition site; other site 903814005416 dimerization interface [polypeptide binding]; other site 903814005417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814005418 DNA binding site [nucleotide binding] 903814005419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814005420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005421 dimer interface [polypeptide binding]; other site 903814005422 phosphorylation site [posttranslational modification] 903814005423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005424 ATP binding site [chemical binding]; other site 903814005425 Mg2+ binding site [ion binding]; other site 903814005426 G-X-G motif; other site 903814005427 TSCPD domain; Region: TSCPD; cl14834 903814005428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814005429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814005430 substrate binding pocket [chemical binding]; other site 903814005431 membrane-bound complex binding site; other site 903814005432 hinge residues; other site 903814005433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814005434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814005435 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 903814005436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814005437 active site 903814005438 motif I; other site 903814005439 motif II; other site 903814005440 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 903814005441 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 903814005442 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 903814005443 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 903814005444 tetramer interface [polypeptide binding]; other site 903814005445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814005446 catalytic residue [active] 903814005447 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 903814005448 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 903814005449 putative deacylase active site [active] 903814005450 Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953 903814005451 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 903814005452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814005453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814005454 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814005456 Walker A/P-loop; other site 903814005457 ATP binding site [chemical binding]; other site 903814005458 Q-loop/lid; other site 903814005459 ABC transporter signature motif; other site 903814005460 Walker B; other site 903814005461 D-loop; other site 903814005462 H-loop/switch region; other site 903814005463 ABC-2 type transporter; Region: ABC2_membrane; cl17235 903814005464 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 903814005465 argininosuccinate lyase; Provisional; Region: PRK00855 903814005466 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 903814005467 active sites [active] 903814005468 tetramer interface [polypeptide binding]; other site 903814005469 argininosuccinate synthase; Provisional; Region: PRK13820 903814005470 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 903814005471 ANP binding site [chemical binding]; other site 903814005472 Substrate Binding Site II [chemical binding]; other site 903814005473 Substrate Binding Site I [chemical binding]; other site 903814005474 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 903814005475 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 903814005476 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 903814005477 heterotetramer interface [polypeptide binding]; other site 903814005478 active site pocket [active] 903814005479 cleavage site 903814005480 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 903814005481 feedback inhibition sensing region; other site 903814005482 homohexameric interface [polypeptide binding]; other site 903814005483 nucleotide binding site [chemical binding]; other site 903814005484 N-acetyl-L-glutamate binding site [chemical binding]; other site 903814005485 acetylornithine aminotransferase; Provisional; Region: PRK02627 903814005486 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 903814005487 inhibitor-cofactor binding pocket; inhibition site 903814005488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814005489 catalytic residue [active] 903814005490 V-type ATP synthase subunit I; Validated; Region: PRK05771 903814005491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814005492 putative substrate translocation pore; other site 903814005493 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 903814005494 ATP synthase subunit C; Region: ATP-synt_C; cl00466 903814005495 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 903814005496 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 903814005497 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 903814005498 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 903814005499 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 903814005500 V-type ATP synthase subunit A; Provisional; Region: PRK04192 903814005501 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 903814005502 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 903814005503 Walker A motif/ATP binding site; other site 903814005504 Walker B motif; other site 903814005505 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 903814005506 V-type ATP synthase subunit B; Provisional; Region: PRK04196 903814005507 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 903814005508 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 903814005509 Walker A motif homologous position; other site 903814005510 Walker B motif; other site 903814005511 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 903814005512 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 903814005513 Probable zinc-binding domain; Region: zf-trcl; pfam13451 903814005514 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 903814005515 GIY-YIG motif/motif A; other site 903814005516 putative active site [active] 903814005517 putative metal binding site [ion binding]; other site 903814005518 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 903814005519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 903814005520 threonine dehydratase; Provisional; Region: PRK08198 903814005521 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 903814005522 tetramer interface [polypeptide binding]; other site 903814005523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814005524 catalytic residue [active] 903814005525 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 903814005526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 903814005527 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 903814005528 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 903814005529 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 903814005530 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 903814005531 Ligand Binding Site [chemical binding]; other site 903814005532 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 903814005533 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 903814005534 active site 903814005535 substrate binding site [chemical binding]; other site 903814005536 metal binding site [ion binding]; metal-binding site 903814005537 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 903814005538 active site 903814005539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814005540 Zn2+ binding site [ion binding]; other site 903814005541 Mg2+ binding site [ion binding]; other site 903814005542 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 903814005543 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814005544 active site 903814005545 DNA binding site [nucleotide binding] 903814005546 Int/Topo IB signature motif; other site 903814005547 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 903814005548 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 903814005549 Cell division protein ZapA; Region: ZapA; pfam05164 903814005550 DNA protecting protein DprA; Region: dprA; TIGR00732 903814005551 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 903814005552 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 903814005553 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 903814005554 putative tRNA-binding site [nucleotide binding]; other site 903814005555 B3/4 domain; Region: B3_4; pfam03483 903814005556 tRNA synthetase B5 domain; Region: B5; smart00874 903814005557 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 903814005558 dimer interface [polypeptide binding]; other site 903814005559 motif 1; other site 903814005560 motif 3; other site 903814005561 motif 2; other site 903814005562 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 903814005563 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 903814005564 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 903814005565 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 903814005566 dimer interface [polypeptide binding]; other site 903814005567 motif 1; other site 903814005568 active site 903814005569 motif 2; other site 903814005570 motif 3; other site 903814005571 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 903814005572 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 903814005573 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 903814005574 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 903814005575 TrkA-N domain; Region: TrkA_N; pfam02254 903814005576 TrkA-C domain; Region: TrkA_C; pfam02080 903814005577 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 903814005578 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 903814005579 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 903814005580 23S rRNA binding site [nucleotide binding]; other site 903814005581 L21 binding site [polypeptide binding]; other site 903814005582 L13 binding site [polypeptide binding]; other site 903814005583 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 903814005584 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 903814005585 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 903814005586 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 903814005587 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 903814005588 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 903814005589 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 903814005590 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 903814005591 active site 903814005592 dimer interface [polypeptide binding]; other site 903814005593 motif 1; other site 903814005594 motif 2; other site 903814005595 motif 3; other site 903814005596 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 903814005597 anticodon binding site; other site 903814005598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 903814005599 Predicted membrane protein [Function unknown]; Region: COG1289 903814005600 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 903814005601 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 903814005602 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 903814005603 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 903814005604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814005605 Coenzyme A binding pocket [chemical binding]; other site 903814005606 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 903814005607 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 903814005608 4Fe-4S binding domain; Region: Fer4; pfam00037 903814005609 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 903814005610 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 903814005611 FAD binding pocket [chemical binding]; other site 903814005612 FAD binding motif [chemical binding]; other site 903814005613 phosphate binding motif [ion binding]; other site 903814005614 beta-alpha-beta structure motif; other site 903814005615 NAD binding pocket [chemical binding]; other site 903814005616 Iron coordination center [ion binding]; other site 903814005617 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 903814005618 Predicted membrane protein [Function unknown]; Region: COG2855 903814005619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814005620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814005621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 903814005622 dimerization interface [polypeptide binding]; other site 903814005623 Histidine kinase; Region: His_kinase; pfam06580 903814005624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005625 Mg2+ binding site [ion binding]; other site 903814005626 G-X-G motif; other site 903814005627 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 903814005628 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 903814005629 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814005630 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814005631 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 903814005632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814005633 MarR family; Region: MarR_2; pfam12802 903814005634 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 903814005635 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 903814005636 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 903814005637 dimer interface [polypeptide binding]; other site 903814005638 Citrate synthase; Region: Citrate_synt; pfam00285 903814005639 active site 903814005640 citrylCoA binding site [chemical binding]; other site 903814005641 oxalacetate/citrate binding site [chemical binding]; other site 903814005642 coenzyme A binding site [chemical binding]; other site 903814005643 catalytic triad [active] 903814005644 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 903814005645 Protein of unknown function DUF45; Region: DUF45; pfam01863 903814005646 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 903814005647 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 903814005648 ligand binding site [chemical binding]; other site 903814005649 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 903814005650 putative switch regulator; other site 903814005651 non-specific DNA interactions [nucleotide binding]; other site 903814005652 DNA binding site [nucleotide binding] 903814005653 sequence specific DNA binding site [nucleotide binding]; other site 903814005654 putative cAMP binding site [chemical binding]; other site 903814005655 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 903814005656 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 903814005657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814005658 ATP binding site [chemical binding]; other site 903814005659 putative Mg++ binding site [ion binding]; other site 903814005660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814005661 nucleotide binding region [chemical binding]; other site 903814005662 ATP-binding site [chemical binding]; other site 903814005663 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 903814005664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005665 active site 903814005666 phosphorylation site [posttranslational modification] 903814005667 intermolecular recognition site; other site 903814005668 dimerization interface [polypeptide binding]; other site 903814005669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 903814005670 DNA binding residues [nucleotide binding] 903814005671 dimerization interface [polypeptide binding]; other site 903814005672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 903814005673 Histidine kinase; Region: HisKA_3; pfam07730 903814005674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005675 ATP binding site [chemical binding]; other site 903814005676 Mg2+ binding site [ion binding]; other site 903814005677 G-X-G motif; other site 903814005678 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814005680 Walker A/P-loop; other site 903814005681 ATP binding site [chemical binding]; other site 903814005682 Q-loop/lid; other site 903814005683 ABC transporter signature motif; other site 903814005684 Walker B; other site 903814005685 D-loop; other site 903814005686 H-loop/switch region; other site 903814005687 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 903814005688 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 903814005689 ABC-2 type transporter; Region: ABC2_membrane; cl17235 903814005690 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 903814005691 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 903814005692 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 903814005693 Predicted membrane protein [Function unknown]; Region: COG4684 903814005694 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 903814005695 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 903814005696 Flavoprotein; Region: Flavoprotein; pfam02441 903814005697 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 903814005698 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 903814005699 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 903814005700 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814005701 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814005702 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814005703 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 903814005704 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 903814005705 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 903814005706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 903814005707 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814005708 AAA domain; Region: AAA_26; pfam13500 903814005709 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 903814005710 biotin synthase; Region: bioB; TIGR00433 903814005711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814005712 FeS/SAM binding site; other site 903814005713 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 903814005714 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 903814005715 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 903814005716 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 903814005717 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 903814005718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 903814005719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 903814005720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814005721 Coenzyme A binding pocket [chemical binding]; other site 903814005722 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 903814005723 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 903814005724 active site 903814005725 Barstar (barnase inhibitor); Region: Barstar; pfam01337 903814005726 RNAase interaction site [polypeptide binding]; other site 903814005727 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 903814005728 Catalytic site [active] 903814005729 Pirin-related protein [General function prediction only]; Region: COG1741 903814005730 Pirin; Region: Pirin; pfam02678 903814005731 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 903814005732 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814005733 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814005734 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814005735 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814005736 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005737 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 903814005738 Walker A/P-loop; other site 903814005739 ATP binding site [chemical binding]; other site 903814005740 Q-loop/lid; other site 903814005741 ABC transporter signature motif; other site 903814005742 Walker B; other site 903814005743 D-loop; other site 903814005744 H-loop/switch region; other site 903814005745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814005746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005747 dimer interface [polypeptide binding]; other site 903814005748 phosphorylation site [posttranslational modification] 903814005749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005750 ATP binding site [chemical binding]; other site 903814005751 Mg2+ binding site [ion binding]; other site 903814005752 G-X-G motif; other site 903814005753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814005754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005755 active site 903814005756 phosphorylation site [posttranslational modification] 903814005757 intermolecular recognition site; other site 903814005758 dimerization interface [polypeptide binding]; other site 903814005759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814005760 DNA binding site [nucleotide binding] 903814005761 short chain dehydrogenase; Provisional; Region: PRK06701 903814005762 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 903814005763 NAD binding site [chemical binding]; other site 903814005764 metal binding site [ion binding]; metal-binding site 903814005765 active site 903814005766 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 903814005767 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 903814005768 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 903814005769 TspO/MBR family; Region: TspO_MBR; pfam03073 903814005770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 903814005771 Tubulin binding cofactor A; Region: TBCA; pfam02970 903814005772 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814005773 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814005774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814005775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814005776 Coenzyme A binding pocket [chemical binding]; other site 903814005777 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 903814005778 active site 903814005779 catalytic residues [active] 903814005780 metal binding site [ion binding]; metal-binding site 903814005781 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 903814005782 homopentamer interface [polypeptide binding]; other site 903814005783 active site 903814005784 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 903814005785 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 903814005786 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 903814005787 dimerization interface [polypeptide binding]; other site 903814005788 active site 903814005789 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 903814005790 Lumazine binding domain; Region: Lum_binding; pfam00677 903814005791 Lumazine binding domain; Region: Lum_binding; pfam00677 903814005792 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 903814005793 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 903814005794 catalytic motif [active] 903814005795 Zn binding site [ion binding]; other site 903814005796 RibD C-terminal domain; Region: RibD_C; cl17279 903814005797 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 903814005798 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814005799 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814005800 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 903814005801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814005802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005803 dimer interface [polypeptide binding]; other site 903814005804 phosphorylation site [posttranslational modification] 903814005805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005806 ATP binding site [chemical binding]; other site 903814005807 Mg2+ binding site [ion binding]; other site 903814005808 G-X-G motif; other site 903814005809 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 903814005810 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 903814005811 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 903814005812 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 903814005813 MOFRL family; Region: MOFRL; pfam05161 903814005814 Peptidase family C69; Region: Peptidase_C69; cl17793 903814005815 Response regulator receiver domain; Region: Response_reg; pfam00072 903814005816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005817 active site 903814005818 phosphorylation site [posttranslational modification] 903814005819 intermolecular recognition site; other site 903814005820 dimerization interface [polypeptide binding]; other site 903814005821 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 903814005822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814005823 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 903814005824 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 903814005825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814005826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005827 dimer interface [polypeptide binding]; other site 903814005828 phosphorylation site [posttranslational modification] 903814005829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005830 ATP binding site [chemical binding]; other site 903814005831 Mg2+ binding site [ion binding]; other site 903814005832 G-X-G motif; other site 903814005833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814005834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005835 active site 903814005836 phosphorylation site [posttranslational modification] 903814005837 intermolecular recognition site; other site 903814005838 dimerization interface [polypeptide binding]; other site 903814005839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814005840 DNA binding site [nucleotide binding] 903814005841 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005842 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 903814005843 Walker A/P-loop; other site 903814005844 ATP binding site [chemical binding]; other site 903814005845 Q-loop/lid; other site 903814005846 ABC transporter signature motif; other site 903814005847 Walker B; other site 903814005848 D-loop; other site 903814005849 H-loop/switch region; other site 903814005850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 903814005851 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814005852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 903814005853 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 903814005854 Glycerol kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK; cd07769 903814005855 N- and C-terminal domain interface [polypeptide binding]; other site 903814005856 active site 903814005857 MgATP binding site [chemical binding]; other site 903814005858 catalytic site [active] 903814005859 metal binding site [ion binding]; metal-binding site 903814005860 glycerol binding site [chemical binding]; other site 903814005861 homotetramer interface [polypeptide binding]; other site 903814005862 homodimer interface [polypeptide binding]; other site 903814005863 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 903814005864 FAD binding domain; Region: FAD_binding_4; pfam01565 903814005865 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814005866 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 903814005867 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814005868 putative active site [active] 903814005869 MgATP binding site [chemical binding]; other site 903814005870 catalytic site [active] 903814005871 metal binding site [ion binding]; metal-binding site 903814005872 putative carbohydrate binding site [chemical binding]; other site 903814005873 BON domain; Region: BON; pfam04972 903814005874 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814005875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814005876 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814005877 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814005878 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 903814005879 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814005880 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 903814005881 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 903814005882 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 903814005883 homotrimer interaction site [polypeptide binding]; other site 903814005884 putative active site [active] 903814005885 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 903814005886 Predicted integral membrane protein [Function unknown]; Region: COG5617 903814005887 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 903814005888 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 903814005889 Walker A/P-loop; other site 903814005890 ATP binding site [chemical binding]; other site 903814005891 Q-loop/lid; other site 903814005892 ABC transporter signature motif; other site 903814005893 Walker B; other site 903814005894 D-loop; other site 903814005895 H-loop/switch region; other site 903814005896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814005897 dimer interface [polypeptide binding]; other site 903814005898 conserved gate region; other site 903814005899 putative PBP binding loops; other site 903814005900 ABC-ATPase subunit interface; other site 903814005901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 903814005902 dimer interface [polypeptide binding]; other site 903814005903 conserved gate region; other site 903814005904 ABC-ATPase subunit interface; other site 903814005905 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 903814005906 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 903814005907 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 903814005908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 903814005909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814005910 catalytic residue [active] 903814005911 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 903814005912 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 903814005913 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 903814005914 dimer interface [polypeptide binding]; other site 903814005915 pyridoxal binding site [chemical binding]; other site 903814005916 ATP binding site [chemical binding]; other site 903814005917 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 903814005918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 903814005919 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 903814005920 putative dimer interface [polypeptide binding]; other site 903814005921 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 903814005922 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814005923 4Fe-4S binding domain; Region: Fer4; cl02805 903814005924 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 903814005925 Uncharacterized conserved protein [Function unknown]; Region: COG4715 903814005926 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 903814005927 trimer interface [polypeptide binding]; other site 903814005928 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 903814005929 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814005930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814005931 active site 903814005932 phosphorylation site [posttranslational modification] 903814005933 intermolecular recognition site; other site 903814005934 dimerization interface [polypeptide binding]; other site 903814005935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814005936 DNA binding site [nucleotide binding] 903814005937 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814005938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814005939 Walker A/P-loop; other site 903814005940 ATP binding site [chemical binding]; other site 903814005941 Q-loop/lid; other site 903814005942 ABC transporter signature motif; other site 903814005943 Walker B; other site 903814005944 D-loop; other site 903814005945 H-loop/switch region; other site 903814005946 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814005947 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814005948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814005949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814005950 dimer interface [polypeptide binding]; other site 903814005951 phosphorylation site [posttranslational modification] 903814005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814005953 ATP binding site [chemical binding]; other site 903814005954 Mg2+ binding site [ion binding]; other site 903814005955 G-X-G motif; other site 903814005956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 903814005957 active site 903814005958 ATP binding site [chemical binding]; other site 903814005959 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 903814005960 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 903814005961 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 903814005962 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 903814005963 methionine aminopeptidase; Provisional; Region: PRK12318 903814005964 SEC-C motif; Region: SEC-C; pfam02810 903814005965 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 903814005966 active site 903814005967 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 903814005968 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 903814005969 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 903814005970 myosin-cross-reactive antigen; Provisional; Region: PRK13977 903814005971 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 903814005972 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 903814005973 Uncharacterized conserved protein [Function unknown]; Region: COG3535 903814005974 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 903814005975 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 903814005976 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 903814005977 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 903814005978 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 903814005979 DNA binding residues [nucleotide binding] 903814005980 drug binding residues [chemical binding]; other site 903814005981 dimer interface [polypeptide binding]; other site 903814005982 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 903814005983 PBP superfamily domain; Region: PBP_like_2; cl17296 903814005984 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 903814005985 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 903814005986 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 903814005987 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 903814005988 FAD binding site [chemical binding]; other site 903814005989 molybdenum-pterin binding domain; Region: Mop; TIGR00638 903814005990 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 903814005991 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 903814005992 active site 903814005993 HIGH motif; other site 903814005994 nucleotide binding site [chemical binding]; other site 903814005995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 903814005996 active site 903814005997 KMSKS motif; other site 903814005998 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 903814005999 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 903814006000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 903814006001 acyl-activating enzyme (AAE) consensus motif; other site 903814006002 AMP binding site [chemical binding]; other site 903814006003 active site 903814006004 CoA binding site [chemical binding]; other site 903814006005 ACT domain-containing protein [General function prediction only]; Region: COG4747 903814006006 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 903814006007 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 903814006008 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 903814006009 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 903814006010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814006011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814006012 putative substrate translocation pore; other site 903814006013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814006014 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814006015 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814006016 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814006017 Helix-turn-helix domain; Region: HTH_36; pfam13730 903814006018 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 903814006019 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 903814006020 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 903814006021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814006022 NAD(P) binding site [chemical binding]; other site 903814006023 active site 903814006024 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 903814006025 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 903814006026 inhibitor-cofactor binding pocket; inhibition site 903814006027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814006028 catalytic residue [active] 903814006029 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 903814006030 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 903814006031 NAD binding site [chemical binding]; other site 903814006032 homotetramer interface [polypeptide binding]; other site 903814006033 homodimer interface [polypeptide binding]; other site 903814006034 substrate binding site [chemical binding]; other site 903814006035 active site 903814006036 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 903814006037 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 903814006038 substrate binding site; other site 903814006039 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 903814006040 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 903814006041 Ligand binding site; other site 903814006042 metal-binding site 903814006043 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 903814006044 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 903814006045 Ligand binding site; other site 903814006046 metal-binding site 903814006047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814006048 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 903814006049 putative ADP-binding pocket [chemical binding]; other site 903814006050 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u1; cd10925 903814006051 NodB motif; other site 903814006052 putative active site [active] 903814006053 putative catalytic site [active] 903814006054 putative Zn binding site [ion binding]; other site 903814006055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 903814006056 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 903814006057 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 903814006058 NAD binding site [chemical binding]; other site 903814006059 substrate binding site [chemical binding]; other site 903814006060 homodimer interface [polypeptide binding]; other site 903814006061 active site 903814006062 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 903814006063 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 903814006064 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 903814006065 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 903814006066 putative ADP-binding pocket [chemical binding]; other site 903814006067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814006068 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 903814006069 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814006070 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 903814006071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814006072 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 903814006073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814006074 NAD(P) binding site [chemical binding]; other site 903814006075 active site 903814006076 Domain of unknown function (DUF348); Region: DUF348; pfam03990 903814006077 G5 domain; Region: G5; pfam07501 903814006078 G5 domain; Region: G5; pfam07501 903814006079 3D domain; Region: 3D; cl01439 903814006080 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 903814006081 V-type ATP synthase subunit B; Provisional; Region: PRK04196 903814006082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 903814006083 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 903814006084 Walker A motif homologous position; other site 903814006085 Walker B motif; other site 903814006086 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 903814006087 V-type ATP synthase subunit A; Provisional; Region: PRK04192 903814006088 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 903814006089 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 903814006090 Walker A motif/ATP binding site; other site 903814006091 Walker B motif; other site 903814006092 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 903814006093 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 903814006094 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 903814006095 V-type ATP synthase subunit I; Validated; Region: PRK05771 903814006096 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 903814006097 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 903814006098 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 903814006099 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 903814006100 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 903814006101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814006102 Walker A/P-loop; other site 903814006103 ATP binding site [chemical binding]; other site 903814006104 Q-loop/lid; other site 903814006105 ABC transporter signature motif; other site 903814006106 Walker B; other site 903814006107 D-loop; other site 903814006108 H-loop/switch region; other site 903814006109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814006110 dimer interface [polypeptide binding]; other site 903814006111 conserved gate region; other site 903814006112 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 903814006113 putative PBP binding loops; other site 903814006114 ABC-ATPase subunit interface; other site 903814006115 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 903814006116 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 903814006117 XdhC Rossmann domain; Region: XdhC_C; pfam13478 903814006118 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 903814006119 putative MPT binding site; other site 903814006120 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 903814006121 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 903814006122 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 903814006123 CPxP motif; other site 903814006124 DsrE/DsrF-like family; Region: DrsE; pfam02635 903814006125 selenophosphate synthetase; Provisional; Region: PRK00943 903814006126 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 903814006127 dimerization interface [polypeptide binding]; other site 903814006128 putative ATP binding site [chemical binding]; other site 903814006129 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 903814006130 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 903814006131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814006132 catalytic residue [active] 903814006133 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 903814006134 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 903814006135 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 903814006136 Ligand binding site; other site 903814006137 metal-binding site 903814006138 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 903814006139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 903814006140 YheO-like PAS domain; Region: PAS_6; pfam08348 903814006141 HTH domain; Region: HTH_22; pfam13309 903814006142 xanthine permease; Region: pbuX; TIGR03173 903814006143 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 903814006144 homotrimer interaction site [polypeptide binding]; other site 903814006145 putative active site [active] 903814006146 carbamate kinase; Reviewed; Region: PRK12686 903814006147 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 903814006148 putative substrate binding site [chemical binding]; other site 903814006149 nucleotide binding site [chemical binding]; other site 903814006150 nucleotide binding site [chemical binding]; other site 903814006151 homodimer interface [polypeptide binding]; other site 903814006152 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 903814006153 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 903814006154 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 903814006155 peptidase; Reviewed; Region: PRK13004 903814006156 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 903814006157 putative metal binding site [ion binding]; other site 903814006158 putative dimer interface [polypeptide binding]; other site 903814006159 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 903814006160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814006161 catalytic residue [active] 903814006162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 903814006163 YheO-like PAS domain; Region: PAS_6; pfam08348 903814006164 HTH domain; Region: HTH_22; pfam13309 903814006165 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 903814006166 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 903814006167 active site 903814006168 putative substrate binding pocket [chemical binding]; other site 903814006169 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 903814006170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814006171 phenylhydantoinase; Validated; Region: PRK08323 903814006172 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 903814006173 tetramer interface [polypeptide binding]; other site 903814006174 active site 903814006175 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 903814006176 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 903814006177 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 903814006178 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 903814006179 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 903814006180 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 903814006181 putative sugar binding sites [chemical binding]; other site 903814006182 Q-X-W motif; other site 903814006183 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 903814006184 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 903814006185 metal-binding site [ion binding] 903814006186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814006187 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814006188 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 903814006189 metal-binding site [ion binding] 903814006190 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 903814006191 putative homodimer interface [polypeptide binding]; other site 903814006192 putative homotetramer interface [polypeptide binding]; other site 903814006193 putative allosteric switch controlling residues; other site 903814006194 putative metal binding site [ion binding]; other site 903814006195 putative homodimer-homodimer interface [polypeptide binding]; other site 903814006196 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 903814006197 Glutaminase; Region: Glutaminase; cl00907 903814006198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814006199 DNA-binding site [nucleotide binding]; DNA binding site 903814006200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814006201 DNA-binding site [nucleotide binding]; DNA binding site 903814006202 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 903814006203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814006204 active site 903814006205 phosphorylation site [posttranslational modification] 903814006206 intermolecular recognition site; other site 903814006207 dimerization interface [polypeptide binding]; other site 903814006208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814006209 Zn2+ binding site [ion binding]; other site 903814006210 Mg2+ binding site [ion binding]; other site 903814006211 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 903814006212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814006213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814006214 metal binding site [ion binding]; metal-binding site 903814006215 active site 903814006216 I-site; other site 903814006217 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 903814006218 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814006219 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 903814006220 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 903814006221 dimerization domain swap beta strand [polypeptide binding]; other site 903814006222 regulatory protein interface [polypeptide binding]; other site 903814006223 active site 903814006224 regulatory phosphorylation site [posttranslational modification]; other site 903814006225 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 903814006226 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 903814006227 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 903814006228 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 903814006229 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 903814006230 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 903814006231 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 903814006232 Glucitol operon activator protein (GutM); Region: GutM; cl01890 903814006233 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 903814006234 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 903814006235 substrate binding site [chemical binding]; other site 903814006236 dimer interface [polypeptide binding]; other site 903814006237 catalytic triad [active] 903814006238 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814006239 intersubunit interface [polypeptide binding]; other site 903814006240 active site 903814006241 zinc binding site [ion binding]; other site 903814006242 Na+ binding site [ion binding]; other site 903814006243 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814006244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814006245 DNA binding residues [nucleotide binding] 903814006246 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814006247 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 903814006248 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 903814006249 active site 903814006250 Riboflavin kinase; Region: Flavokinase; pfam01687 903814006251 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 903814006252 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 903814006253 RNA binding site [nucleotide binding]; other site 903814006254 active site 903814006255 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 903814006256 DHH family; Region: DHH; pfam01368 903814006257 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 903814006258 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 903814006259 translation initiation factor IF-2; Region: IF-2; TIGR00487 903814006260 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 903814006261 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 903814006262 G1 box; other site 903814006263 putative GEF interaction site [polypeptide binding]; other site 903814006264 GTP/Mg2+ binding site [chemical binding]; other site 903814006265 Switch I region; other site 903814006266 G2 box; other site 903814006267 G3 box; other site 903814006268 Switch II region; other site 903814006269 G4 box; other site 903814006270 G5 box; other site 903814006271 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 903814006272 Translation-initiation factor 2; Region: IF-2; pfam11987 903814006273 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 903814006274 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 903814006275 putative RNA binding cleft [nucleotide binding]; other site 903814006276 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 903814006277 NusA N-terminal domain; Region: NusA_N; pfam08529 903814006278 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 903814006279 RNA binding site [nucleotide binding]; other site 903814006280 homodimer interface [polypeptide binding]; other site 903814006281 NusA-like KH domain; Region: KH_5; pfam13184 903814006282 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 903814006283 G-X-X-G motif; other site 903814006284 Sm and related proteins; Region: Sm_like; cl00259 903814006285 ribosome maturation protein RimP; Reviewed; Region: PRK00092 903814006286 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 903814006287 putative oligomer interface [polypeptide binding]; other site 903814006288 putative RNA binding site [nucleotide binding]; other site 903814006289 ribosome recycling factor; Reviewed; Region: frr; PRK00083 903814006290 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 903814006291 hinge region; other site 903814006292 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 903814006293 putative nucleotide binding site [chemical binding]; other site 903814006294 uridine monophosphate binding site [chemical binding]; other site 903814006295 homohexameric interface [polypeptide binding]; other site 903814006296 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 903814006297 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814006298 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814006299 BCCT family transporter; Region: BCCT; pfam02028 903814006300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814006301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814006302 putative substrate translocation pore; other site 903814006303 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814006304 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 903814006305 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 903814006306 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 903814006307 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 903814006308 potential frameshift: common BLAST hit: gi|310827186|ref|YP_003959543.1| glycerol kinase 903814006309 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 903814006310 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814006311 nucleotide binding site [chemical binding]; other site 903814006312 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814006313 nucleotide binding site [chemical binding]; other site 903814006314 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814006315 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 903814006316 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814006317 UBA/TS-N domain; Region: UBA; pfam00627 903814006318 elongation factor Ts; Reviewed; Region: tsf; PRK12332 903814006319 Elongation factor TS; Region: EF_TS; pfam00889 903814006320 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 903814006321 rRNA interaction site [nucleotide binding]; other site 903814006322 S8 interaction site; other site 903814006323 putative laminin-1 binding site; other site 903814006324 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 903814006325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814006326 Walker A motif; other site 903814006327 ATP binding site [chemical binding]; other site 903814006328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 903814006329 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 903814006330 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 903814006331 active site 903814006332 HslU subunit interaction site [polypeptide binding]; other site 903814006333 DNA topoisomerase I; Validated; Region: PRK05582 903814006334 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 903814006335 active site 903814006336 interdomain interaction site; other site 903814006337 putative metal-binding site [ion binding]; other site 903814006338 nucleotide binding site [chemical binding]; other site 903814006339 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 903814006340 domain I; other site 903814006341 DNA binding groove [nucleotide binding] 903814006342 phosphate binding site [ion binding]; other site 903814006343 domain II; other site 903814006344 domain III; other site 903814006345 nucleotide binding site [chemical binding]; other site 903814006346 catalytic site [active] 903814006347 domain IV; other site 903814006348 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 903814006349 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 903814006350 DNA protecting protein DprA; Region: dprA; TIGR00732 903814006351 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 903814006352 Cache domain; Region: Cache_1; pfam02743 903814006353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814006354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814006355 metal binding site [ion binding]; metal-binding site 903814006356 active site 903814006357 I-site; other site 903814006358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814006359 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 903814006360 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 903814006361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814006362 Walker A motif; other site 903814006363 ATP binding site [chemical binding]; other site 903814006364 Walker B motif; other site 903814006365 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 903814006366 amidophosphoribosyltransferase; Region: purF; TIGR01134 903814006367 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 903814006368 active site 903814006369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814006370 active site 903814006371 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 903814006372 LytB protein; Region: LYTB; cl00507 903814006373 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 903814006374 RNA binding site [nucleotide binding]; other site 903814006375 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 903814006376 RNA binding site [nucleotide binding]; other site 903814006377 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 903814006378 RNA binding site [nucleotide binding]; other site 903814006379 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 903814006380 RNA binding site [nucleotide binding]; other site 903814006381 domain interface; other site 903814006382 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 903814006383 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 903814006384 putative acyl-acceptor binding pocket; other site 903814006385 cytidylate kinase; Provisional; Region: cmk; PRK00023 903814006386 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 903814006387 CMP-binding site; other site 903814006388 The sites determining sugar specificity; other site 903814006389 flavoprotein, HI0933 family; Region: TIGR00275 903814006390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814006391 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 903814006392 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 903814006393 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 903814006394 putative active site [active] 903814006395 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 903814006396 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 903814006397 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814006398 RNA binding surface [nucleotide binding]; other site 903814006399 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 903814006400 active site 903814006401 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 903814006402 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 903814006403 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 903814006404 Peptidase family M50; Region: Peptidase_M50; pfam02163 903814006405 active site 903814006406 putative substrate binding region [chemical binding]; other site 903814006407 diaminopimelate decarboxylase; Region: lysA; TIGR01048 903814006408 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 903814006409 active site 903814006410 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 903814006411 substrate binding site [chemical binding]; other site 903814006412 catalytic residues [active] 903814006413 dimer interface [polypeptide binding]; other site 903814006414 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 903814006415 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 903814006416 dimer interface [polypeptide binding]; other site 903814006417 ADP-ribose binding site [chemical binding]; other site 903814006418 active site 903814006419 nudix motif; other site 903814006420 metal binding site [ion binding]; metal-binding site 903814006421 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 903814006422 ATP cone domain; Region: ATP-cone; pfam03477 903814006423 cell division protein FtsZ; Validated; Region: PRK09330 903814006424 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 903814006425 nucleotide binding site [chemical binding]; other site 903814006426 SulA interaction site; other site 903814006427 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 903814006428 The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor...; Region: Link_Domain; cl02612 903814006429 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 903814006430 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 903814006431 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 903814006432 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 903814006433 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 903814006434 active site 903814006435 homodimer interface [polypeptide binding]; other site 903814006436 cell division protein FtsW; Region: ftsW; TIGR02614 903814006437 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 903814006438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 903814006439 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 903814006440 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 903814006441 Mg++ binding site [ion binding]; other site 903814006442 putative catalytic motif [active] 903814006443 putative substrate binding site [chemical binding]; other site 903814006444 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 903814006445 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 903814006446 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 903814006447 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 903814006448 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 903814006449 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 903814006450 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 903814006451 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 903814006452 Septum formation initiator; Region: DivIC; cl17659 903814006453 MraW methylase family; Region: Methyltransf_5; pfam01795 903814006454 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 903814006455 cell division protein MraZ; Reviewed; Region: PRK00326 903814006456 MraZ protein; Region: MraZ; pfam02381 903814006457 MraZ protein; Region: MraZ; pfam02381 903814006458 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 903814006459 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 903814006460 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 903814006461 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 903814006462 4Fe-4S binding domain; Region: Fer4; pfam00037 903814006463 4Fe-4S binding domain; Region: Fer4_6; pfam12837 903814006464 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 903814006465 HSF-type DNA-binding; Region: HSF_DNA-bind; cl12113 903814006466 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 903814006467 active site 903814006468 catalytic triad [active] 903814006469 oxyanion hole [active] 903814006470 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 903814006471 Putative amidase domain; Region: Amidase_6; pfam12671 903814006472 Transcriptional regulators [Transcription]; Region: MarR; COG1846 903814006473 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 903814006474 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 903814006475 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814006476 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 903814006477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814006478 FeS/SAM binding site; other site 903814006479 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814006480 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814006481 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814006482 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814006483 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814006484 DNA binding residues [nucleotide binding] 903814006485 BRO family, N-terminal domain; Region: Bro-N; smart01040 903814006486 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 903814006487 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 903814006488 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 903814006489 inhibitor-cofactor binding pocket; inhibition site 903814006490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814006491 catalytic residue [active] 903814006492 putative trimer interface [polypeptide binding]; other site 903814006493 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 903814006494 putative CoA binding site [chemical binding]; other site 903814006495 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 903814006496 putative trimer interface [polypeptide binding]; other site 903814006497 putative active site [active] 903814006498 putative substrate binding site [chemical binding]; other site 903814006499 putative CoA binding site [chemical binding]; other site 903814006500 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 903814006501 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 903814006502 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 903814006503 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 903814006504 active site 903814006505 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 903814006506 homodimer interface [polypeptide binding]; other site 903814006507 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 903814006508 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 903814006509 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 903814006510 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 903814006511 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 903814006512 putative CoA binding site [chemical binding]; other site 903814006513 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 903814006514 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 903814006515 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 903814006516 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 903814006517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814006518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814006519 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 903814006520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 903814006521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 903814006522 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 903814006523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814006524 NAD(P) binding site [chemical binding]; other site 903814006525 active site 903814006526 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814006527 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 903814006528 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 903814006529 inhibitor-cofactor binding pocket; inhibition site 903814006530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814006531 catalytic residue [active] 903814006532 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 903814006533 G1 box; other site 903814006534 GTP/Mg2+ binding site [chemical binding]; other site 903814006535 G2 box; other site 903814006536 Switch I region; other site 903814006537 G3 box; other site 903814006538 Switch II region; other site 903814006539 G4 box; other site 903814006540 G5 box; other site 903814006541 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 903814006542 G1 box; other site 903814006543 GTP/Mg2+ binding site [chemical binding]; other site 903814006544 G2 box; other site 903814006545 Switch I region; other site 903814006546 G3 box; other site 903814006547 Switch II region; other site 903814006548 G4 box; other site 903814006549 G5 box; other site 903814006550 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 903814006551 serine O-acetyltransferase; Region: cysE; TIGR01172 903814006552 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 903814006553 trimer interface [polypeptide binding]; other site 903814006554 active site 903814006555 substrate binding site [chemical binding]; other site 903814006556 CoA binding site [chemical binding]; other site 903814006557 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 903814006558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814006559 Walker A/P-loop; other site 903814006560 ATP binding site [chemical binding]; other site 903814006561 Q-loop/lid; other site 903814006562 ABC transporter signature motif; other site 903814006563 Walker B; other site 903814006564 D-loop; other site 903814006565 H-loop/switch region; other site 903814006566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814006567 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 903814006568 Walker A/P-loop; other site 903814006569 ATP binding site [chemical binding]; other site 903814006570 Q-loop/lid; other site 903814006571 ABC transporter signature motif; other site 903814006572 Walker B; other site 903814006573 D-loop; other site 903814006574 H-loop/switch region; other site 903814006575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 903814006576 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 903814006577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814006578 dimer interface [polypeptide binding]; other site 903814006579 conserved gate region; other site 903814006580 putative PBP binding loops; other site 903814006581 ABC-ATPase subunit interface; other site 903814006582 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 903814006583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814006584 dimer interface [polypeptide binding]; other site 903814006585 conserved gate region; other site 903814006586 putative PBP binding loops; other site 903814006587 ABC-ATPase subunit interface; other site 903814006588 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 903814006589 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 903814006590 substrate binding site [chemical binding]; other site 903814006591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814006592 S-adenosylmethionine binding site [chemical binding]; other site 903814006593 HD domain; Region: HD_4; pfam13328 903814006594 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814006595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814006596 non-specific DNA binding site [nucleotide binding]; other site 903814006597 salt bridge; other site 903814006598 sequence-specific DNA binding site [nucleotide binding]; other site 903814006599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814006600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814006601 dimerization interface [polypeptide binding]; other site 903814006602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814006603 dimer interface [polypeptide binding]; other site 903814006604 phosphorylation site [posttranslational modification] 903814006605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814006606 ATP binding site [chemical binding]; other site 903814006607 Mg2+ binding site [ion binding]; other site 903814006608 G-X-G motif; other site 903814006609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814006610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814006611 active site 903814006612 phosphorylation site [posttranslational modification] 903814006613 intermolecular recognition site; other site 903814006614 dimerization interface [polypeptide binding]; other site 903814006615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814006616 DNA binding site [nucleotide binding] 903814006617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814006618 HAMP domain; Region: HAMP; pfam00672 903814006619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814006620 dimer interface [polypeptide binding]; other site 903814006621 phosphorylation site [posttranslational modification] 903814006622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814006623 ATP binding site [chemical binding]; other site 903814006624 Mg2+ binding site [ion binding]; other site 903814006625 G-X-G motif; other site 903814006626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814006627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814006628 active site 903814006629 phosphorylation site [posttranslational modification] 903814006630 intermolecular recognition site; other site 903814006631 dimerization interface [polypeptide binding]; other site 903814006632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814006633 DNA binding site [nucleotide binding] 903814006634 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 903814006635 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814006636 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 903814006637 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814006638 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 903814006639 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 903814006640 Walker A/P-loop; other site 903814006641 ATP binding site [chemical binding]; other site 903814006642 Q-loop/lid; other site 903814006643 ABC transporter signature motif; other site 903814006644 Walker B; other site 903814006645 D-loop; other site 903814006646 H-loop/switch region; other site 903814006647 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 903814006648 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 903814006649 metal binding site [ion binding]; metal-binding site 903814006650 dimer interface [polypeptide binding]; other site 903814006651 stage V sporulation protein B; Region: spore_V_B; TIGR02900 903814006652 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 903814006653 maltose O-acetyltransferase; Provisional; Region: PRK10092 903814006654 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 903814006655 active site 903814006656 substrate binding site [chemical binding]; other site 903814006657 trimer interface [polypeptide binding]; other site 903814006658 CoA binding site [chemical binding]; other site 903814006659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814006660 Coenzyme A binding pocket [chemical binding]; other site 903814006661 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 903814006662 Domain of unknown function DUF87; Region: DUF87; pfam01935 903814006663 FtsH Extracellular; Region: FtsH_ext; pfam06480 903814006664 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 903814006665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814006666 Walker A motif; other site 903814006667 ATP binding site [chemical binding]; other site 903814006668 Walker B motif; other site 903814006669 arginine finger; other site 903814006670 Peptidase family M41; Region: Peptidase_M41; pfam01434 903814006671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814006672 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 903814006673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 903814006674 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 903814006675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814006676 salt bridge; other site 903814006677 non-specific DNA binding site [nucleotide binding]; other site 903814006678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814006679 sequence-specific DNA binding site [nucleotide binding]; other site 903814006680 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 903814006681 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 903814006682 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 903814006683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814006684 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 903814006685 DNA-binding interface [nucleotide binding]; DNA binding site 903814006686 Cache domain; Region: Cache_1; pfam02743 903814006687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814006688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814006689 metal binding site [ion binding]; metal-binding site 903814006690 active site 903814006691 I-site; other site 903814006692 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814006693 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 903814006694 OsmC-like protein; Region: OsmC; pfam02566 903814006695 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 903814006696 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 903814006697 ligand binding site [chemical binding]; other site 903814006698 flexible hinge region; other site 903814006699 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 903814006700 non-specific DNA interactions [nucleotide binding]; other site 903814006701 DNA binding site [nucleotide binding] 903814006702 sequence specific DNA binding site [nucleotide binding]; other site 903814006703 putative cAMP binding site [chemical binding]; other site 903814006704 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 903814006705 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 903814006706 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 903814006707 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 903814006708 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 903814006709 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 903814006710 glycerate kinase; Region: TIGR00045 903814006711 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 903814006712 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 903814006713 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 903814006714 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 903814006715 Ligand Binding Site [chemical binding]; other site 903814006716 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 903814006717 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 903814006718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814006719 catalytic residue [active] 903814006720 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 903814006721 trimer interface [polypeptide binding]; other site 903814006722 active site 903814006723 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 903814006724 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 903814006725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814006726 non-specific DNA binding site [nucleotide binding]; other site 903814006727 salt bridge; other site 903814006728 sequence-specific DNA binding site [nucleotide binding]; other site 903814006729 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 903814006730 Catalytic site [active] 903814006731 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814006732 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814006733 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814006734 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 903814006735 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 903814006736 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 903814006737 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814006738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814006739 ABC transporter; Region: ABC_tran_2; pfam12848 903814006740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814006741 ferredoxin; Validated; Region: PRK07118 903814006742 Putative Fe-S cluster; Region: FeS; cl17515 903814006743 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814006744 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814006745 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion]; Region: RnfA; COG4657 903814006746 electron transport complex RsxE subunit; Provisional; Region: PRK12405 903814006747 FMN-binding domain; Region: FMN_bind; cl01081 903814006748 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 903814006749 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 903814006750 SLBB domain; Region: SLBB; pfam10531 903814006751 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814006752 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 903814006753 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 903814006754 oligomer interface [polypeptide binding]; other site 903814006755 putative active site [active] 903814006756 metal binding site [ion binding]; metal-binding site 903814006757 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 903814006758 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 903814006759 Methyltransferase domain; Region: Methyltransf_23; pfam13489 903814006760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814006761 S-adenosylmethionine binding site [chemical binding]; other site 903814006762 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 903814006763 Aluminium resistance protein; Region: Alum_res; pfam06838 903814006764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814006765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814006766 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 903814006767 Walker A/P-loop; other site 903814006768 ATP binding site [chemical binding]; other site 903814006769 Q-loop/lid; other site 903814006770 ABC transporter signature motif; other site 903814006771 Walker B; other site 903814006772 D-loop; other site 903814006773 H-loop/switch region; other site 903814006774 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 903814006775 dinuclear metal binding motif [ion binding]; other site 903814006776 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 903814006777 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 903814006778 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 903814006779 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 903814006780 TrkA-N domain; Region: TrkA_N; pfam02254 903814006781 TrkA-C domain; Region: TrkA_C; pfam02080 903814006782 TrkA-N domain; Region: TrkA_N; pfam02254 903814006783 TrkA-C domain; Region: TrkA_C; pfam02080 903814006784 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 903814006785 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 903814006786 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 903814006787 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 903814006788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814006789 ATP binding site [chemical binding]; other site 903814006790 Mg2+ binding site [ion binding]; other site 903814006791 G-X-G motif; other site 903814006792 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 903814006793 ATP binding site [chemical binding]; other site 903814006794 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 903814006795 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 903814006796 MutS domain I; Region: MutS_I; pfam01624 903814006797 MutS domain II; Region: MutS_II; pfam05188 903814006798 MutS domain III; Region: MutS_III; pfam05192 903814006799 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 903814006800 Walker A/P-loop; other site 903814006801 ATP binding site [chemical binding]; other site 903814006802 Q-loop/lid; other site 903814006803 ABC transporter signature motif; other site 903814006804 Walker B; other site 903814006805 D-loop; other site 903814006806 H-loop/switch region; other site 903814006807 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 903814006808 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 903814006809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814006810 FeS/SAM binding site; other site 903814006811 TRAM domain; Region: TRAM; pfam01938 903814006812 putative carbohydrate kinase; Provisional; Region: PRK10565 903814006813 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 903814006814 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 903814006815 putative substrate binding site [chemical binding]; other site 903814006816 putative ATP binding site [chemical binding]; other site 903814006817 hypothetical protein; Validated; Region: PRK00110 903814006818 Uncharacterized conserved protein [Function unknown]; Region: COG1739 903814006819 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 903814006820 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 903814006821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 903814006822 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 903814006823 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 903814006824 HflX GTPase family; Region: HflX; cd01878 903814006825 G1 box; other site 903814006826 GTP/Mg2+ binding site [chemical binding]; other site 903814006827 Switch I region; other site 903814006828 G2 box; other site 903814006829 G3 box; other site 903814006830 Switch II region; other site 903814006831 G4 box; other site 903814006832 G5 box; other site 903814006833 Transglycosylase; Region: Transgly; pfam00912 903814006834 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 903814006835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 903814006836 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 903814006837 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 903814006838 Na binding site [ion binding]; other site 903814006839 hypothetical protein; Provisional; Region: PRK08328 903814006840 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 903814006841 ATP binding site [chemical binding]; other site 903814006842 substrate interface [chemical binding]; other site 903814006843 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 903814006844 MPT binding site; other site 903814006845 trimer interface [polypeptide binding]; other site 903814006846 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814006847 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814006848 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814006849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814006850 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 903814006851 DNA binding residues [nucleotide binding] 903814006852 Helix-turn-helix domain; Region: HTH_36; pfam13730 903814006853 BRO family, N-terminal domain; Region: Bro-N; cl10591 903814006854 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 903814006855 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 903814006856 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 903814006857 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 903814006858 inhibitor-cofactor binding pocket; inhibition site 903814006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814006860 catalytic residue [active] 903814006861 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 903814006862 ligand binding site; other site 903814006863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 903814006864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 903814006865 active site 903814006866 catalytic tetrad [active] 903814006867 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 903814006868 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 903814006869 NeuB family; Region: NeuB; pfam03102 903814006870 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 903814006871 NeuB binding interface [polypeptide binding]; other site 903814006872 putative substrate binding site [chemical binding]; other site 903814006873 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 903814006874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814006875 NAD(P) binding site [chemical binding]; other site 903814006876 active site 903814006877 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 903814006878 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 903814006879 NAD(P) binding site [chemical binding]; other site 903814006880 homodimer interface [polypeptide binding]; other site 903814006881 substrate binding site [chemical binding]; other site 903814006882 active site 903814006883 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 903814006884 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 903814006885 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 903814006886 trimer interface [polypeptide binding]; other site 903814006887 active site 903814006888 substrate binding site [chemical binding]; other site 903814006889 CoA binding site [chemical binding]; other site 903814006890 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 903814006891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 903814006892 active site 903814006893 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 903814006894 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 903814006895 trimer interface [polypeptide binding]; other site 903814006896 active site 903814006897 substrate binding site [chemical binding]; other site 903814006898 CoA binding site [chemical binding]; other site 903814006899 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 903814006900 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 903814006901 NAD binding site [chemical binding]; other site 903814006902 substrate binding site [chemical binding]; other site 903814006903 homodimer interface [polypeptide binding]; other site 903814006904 active site 903814006905 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 903814006906 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 903814006907 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 903814006908 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 903814006909 putative ADP-binding pocket [chemical binding]; other site 903814006910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814006911 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814006912 Probable transposase; Region: OrfB_IS605; pfam01385 903814006913 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 903814006914 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 903814006915 GSH binding site [chemical binding]; other site 903814006916 catalytic residues [active] 903814006917 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814006918 active site 903814006919 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 903814006920 BCCT family transporter; Region: BCCT; pfam02028 903814006921 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814006922 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814006923 PAS domain; Region: PAS_9; pfam13426 903814006924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814006925 putative active site [active] 903814006926 heme pocket [chemical binding]; other site 903814006927 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814006928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814006929 Walker A motif; other site 903814006930 ATP binding site [chemical binding]; other site 903814006931 Walker B motif; other site 903814006932 arginine finger; other site 903814006933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 903814006934 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814006935 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814006936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814006937 putative substrate translocation pore; other site 903814006938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814006939 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 903814006940 Uncharacterized conserved protein [Function unknown]; Region: COG2006 903814006941 4Fe-4S binding domain; Region: Fer4; pfam00037 903814006942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814006943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814006944 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814006945 Walker A/P-loop; other site 903814006946 ATP binding site [chemical binding]; other site 903814006947 Q-loop/lid; other site 903814006948 ABC transporter signature motif; other site 903814006949 Walker B; other site 903814006950 D-loop; other site 903814006951 H-loop/switch region; other site 903814006952 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814006953 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814006954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814006955 Walker A/P-loop; other site 903814006956 ATP binding site [chemical binding]; other site 903814006957 Q-loop/lid; other site 903814006958 ABC transporter signature motif; other site 903814006959 Walker B; other site 903814006960 D-loop; other site 903814006961 H-loop/switch region; other site 903814006962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814006963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814006964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 903814006965 dimerization interface [polypeptide binding]; other site 903814006966 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 903814006967 Ca2+ binding site [ion binding]; other site 903814006968 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 903814006969 Interdomain contacts; other site 903814006970 Cytokine receptor motif; other site 903814006971 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 903814006972 Interdomain contacts; other site 903814006973 Cytokine receptor motif; other site 903814006974 Peptidase M60-like family; Region: M60-like; pfam13402 903814006975 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 903814006976 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 903814006977 PhoU domain; Region: PhoU; pfam01895 903814006978 PhoU domain; Region: PhoU; pfam01895 903814006979 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 903814006980 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 903814006981 Walker A/P-loop; other site 903814006982 ATP binding site [chemical binding]; other site 903814006983 Q-loop/lid; other site 903814006984 ABC transporter signature motif; other site 903814006985 Walker B; other site 903814006986 D-loop; other site 903814006987 H-loop/switch region; other site 903814006988 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 903814006989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814006990 dimer interface [polypeptide binding]; other site 903814006991 conserved gate region; other site 903814006992 putative PBP binding loops; other site 903814006993 ABC-ATPase subunit interface; other site 903814006994 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 903814006995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814006996 dimer interface [polypeptide binding]; other site 903814006997 conserved gate region; other site 903814006998 putative PBP binding loops; other site 903814006999 ABC-ATPase subunit interface; other site 903814007000 PBP superfamily domain; Region: PBP_like_2; cl17296 903814007001 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 903814007002 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 903814007003 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814007004 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814007005 Rubredoxin [Energy production and conversion]; Region: COG1773 903814007006 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 903814007007 iron binding site [ion binding]; other site 903814007008 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 903814007009 iron binding site [ion binding]; other site 903814007010 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 903814007011 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 903814007012 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 903814007013 PYR/PP interface [polypeptide binding]; other site 903814007014 dimer interface [polypeptide binding]; other site 903814007015 TPP binding site [chemical binding]; other site 903814007016 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 903814007017 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 903814007018 TPP-binding site [chemical binding]; other site 903814007019 dimer interface [polypeptide binding]; other site 903814007020 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 903814007021 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 903814007022 tartrate dehydrogenase; Region: TTC; TIGR02089 903814007023 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 903814007024 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 903814007025 substrate binding site [chemical binding]; other site 903814007026 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 903814007027 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 903814007028 substrate binding site [chemical binding]; other site 903814007029 ligand binding site [chemical binding]; other site 903814007030 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 903814007031 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 903814007032 active site 903814007033 catalytic residues [active] 903814007034 metal binding site [ion binding]; metal-binding site 903814007035 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 903814007036 ketol-acid reductoisomerase; Provisional; Region: PRK05479 903814007037 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 903814007038 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 903814007039 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 903814007040 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 903814007041 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 903814007042 active site 903814007043 catalytic site [active] 903814007044 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 903814007045 nucleoside/Zn binding site; other site 903814007046 dimer interface [polypeptide binding]; other site 903814007047 catalytic motif [active] 903814007048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814007050 Walker A/P-loop; other site 903814007051 ATP binding site [chemical binding]; other site 903814007052 Q-loop/lid; other site 903814007053 ABC transporter signature motif; other site 903814007054 Walker B; other site 903814007055 D-loop; other site 903814007056 H-loop/switch region; other site 903814007057 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 903814007058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 903814007059 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 903814007060 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814007061 substrate binding pocket [chemical binding]; other site 903814007062 membrane-bound complex binding site; other site 903814007063 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 903814007064 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 903814007065 active site 903814007066 NAD binding site [chemical binding]; other site 903814007067 metal binding site [ion binding]; metal-binding site 903814007068 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 903814007069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814007070 Walker A motif; other site 903814007071 ATP binding site [chemical binding]; other site 903814007072 Walker B motif; other site 903814007073 arginine finger; other site 903814007074 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 903814007075 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814007076 MarR family; Region: MarR_2; cl17246 903814007077 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 903814007078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814007079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814007080 motif II; other site 903814007081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814007082 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 903814007083 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814007084 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 903814007085 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 903814007086 FeoA domain; Region: FeoA; pfam04023 903814007087 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 903814007088 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 903814007089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814007090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814007091 motif II; other site 903814007092 Protein of unknown function (DUF454); Region: DUF454; cl01063 903814007093 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 903814007094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814007095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007096 Walker A/P-loop; other site 903814007097 ATP binding site [chemical binding]; other site 903814007098 Q-loop/lid; other site 903814007099 ABC transporter signature motif; other site 903814007100 Walker B; other site 903814007101 D-loop; other site 903814007102 H-loop/switch region; other site 903814007103 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814007104 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814007105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007106 Walker A/P-loop; other site 903814007107 ATP binding site [chemical binding]; other site 903814007108 Q-loop/lid; other site 903814007109 ABC transporter signature motif; other site 903814007110 Walker B; other site 903814007111 D-loop; other site 903814007112 H-loop/switch region; other site 903814007113 hypothetical protein; Provisional; Region: PRK10410 903814007114 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 903814007115 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 903814007116 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 903814007117 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 903814007118 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 903814007119 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814007120 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 903814007121 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 903814007122 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 903814007123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814007124 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814007125 EamA-like transporter family; Region: EamA; pfam00892 903814007126 EamA-like transporter family; Region: EamA; pfam00892 903814007127 NAD-dependent deacetylase; Provisional; Region: PRK00481 903814007128 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 903814007129 Phospholipid methyltransferase; Region: PEMT; cl17370 903814007130 integron integrase; Region: integrase_gron; TIGR02249 903814007131 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814007132 active site 903814007133 DNA binding site [nucleotide binding] 903814007134 Int/Topo IB signature motif; other site 903814007135 Helix-turn-helix domain; Region: HTH_17; cl17695 903814007136 Domain of unknown function (DUF955); Region: DUF955; pfam06114 903814007137 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 903814007138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814007139 Coenzyme A binding pocket [chemical binding]; other site 903814007140 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 903814007141 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814007142 DNA binding residues [nucleotide binding] 903814007143 drug binding residues [chemical binding]; other site 903814007144 dimer interface [polypeptide binding]; other site 903814007145 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 903814007146 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 903814007147 active site 903814007148 catalytic triad [active] 903814007149 oxyanion hole [active] 903814007150 HTH domain; Region: HTH_11; pfam08279 903814007151 WYL domain; Region: WYL; pfam13280 903814007152 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 903814007153 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 903814007154 PYR/PP interface [polypeptide binding]; other site 903814007155 dimer interface [polypeptide binding]; other site 903814007156 TPP binding site [chemical binding]; other site 903814007157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 903814007158 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 903814007159 TPP-binding site [chemical binding]; other site 903814007160 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 903814007161 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 903814007162 TPP-binding site [chemical binding]; other site 903814007163 putative dimer interface [polypeptide binding]; other site 903814007164 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 903814007165 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 903814007166 dimer interface [polypeptide binding]; other site 903814007167 PYR/PP interface [polypeptide binding]; other site 903814007168 TPP binding site [chemical binding]; other site 903814007169 substrate binding site [chemical binding]; other site 903814007170 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 903814007171 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814007172 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 903814007173 BCCT family transporter; Region: BCCT; pfam02028 903814007174 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 903814007175 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 903814007176 substrate binding site [chemical binding]; other site 903814007177 Predicted aconitase [General function prediction only]; Region: COG1679 903814007178 Protein of unknown function (DUF521); Region: DUF521; pfam04412 903814007179 PAS domain; Region: PAS; smart00091 903814007180 PAS fold; Region: PAS_4; pfam08448 903814007181 putative active site [active] 903814007182 heme pocket [chemical binding]; other site 903814007183 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 903814007184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814007185 Walker A motif; other site 903814007186 ATP binding site [chemical binding]; other site 903814007187 Walker B motif; other site 903814007188 arginine finger; other site 903814007189 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 903814007190 homotrimer interaction site [polypeptide binding]; other site 903814007191 putative active site [active] 903814007192 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814007193 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 903814007194 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 903814007195 AAA domain; Region: AAA_25; pfam13481 903814007196 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 903814007197 Walker A motif; other site 903814007198 ATP binding site [chemical binding]; other site 903814007199 Walker B motif; other site 903814007200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814007201 non-specific DNA binding site [nucleotide binding]; other site 903814007202 salt bridge; other site 903814007203 sequence-specific DNA binding site [nucleotide binding]; other site 903814007204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814007205 non-specific DNA binding site [nucleotide binding]; other site 903814007206 salt bridge; other site 903814007207 sequence-specific DNA binding site [nucleotide binding]; other site 903814007208 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 903814007209 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 903814007210 active site 903814007211 catalytic residues [active] 903814007212 DNA binding site [nucleotide binding] 903814007213 Int/Topo IB signature motif; other site 903814007214 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 903814007215 catalytic core [active] 903814007216 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 903814007217 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 903814007218 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814007219 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 903814007220 intersubunit interface [polypeptide binding]; other site 903814007221 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 903814007222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814007223 ABC-ATPase subunit interface; other site 903814007224 dimer interface [polypeptide binding]; other site 903814007225 putative PBP binding regions; other site 903814007226 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814007227 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814007228 Walker A/P-loop; other site 903814007229 ATP binding site [chemical binding]; other site 903814007230 Q-loop/lid; other site 903814007231 ABC transporter signature motif; other site 903814007232 Walker B; other site 903814007233 D-loop; other site 903814007234 H-loop/switch region; other site 903814007235 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 903814007236 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 903814007237 XdhC Rossmann domain; Region: XdhC_C; pfam13478 903814007238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814007239 putative substrate translocation pore; other site 903814007240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814007241 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814007242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814007243 PAS domain; Region: PAS_9; pfam13426 903814007244 putative active site [active] 903814007245 heme pocket [chemical binding]; other site 903814007246 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814007247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814007248 Walker A motif; other site 903814007249 ATP binding site [chemical binding]; other site 903814007250 Walker B motif; other site 903814007251 arginine finger; other site 903814007252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 903814007253 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 903814007254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007255 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 903814007256 Walker A/P-loop; other site 903814007257 ATP binding site [chemical binding]; other site 903814007258 Q-loop/lid; other site 903814007259 ABC transporter signature motif; other site 903814007260 Walker B; other site 903814007261 D-loop; other site 903814007262 H-loop/switch region; other site 903814007263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814007264 dimer interface [polypeptide binding]; other site 903814007265 conserved gate region; other site 903814007266 putative PBP binding loops; other site 903814007267 ABC-ATPase subunit interface; other site 903814007268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814007269 dimer interface [polypeptide binding]; other site 903814007270 conserved gate region; other site 903814007271 putative PBP binding loops; other site 903814007272 ABC-ATPase subunit interface; other site 903814007273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814007274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814007275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007276 Walker A/P-loop; other site 903814007277 ATP binding site [chemical binding]; other site 903814007278 Q-loop/lid; other site 903814007279 ABC transporter signature motif; other site 903814007280 Walker B; other site 903814007281 D-loop; other site 903814007282 H-loop/switch region; other site 903814007283 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814007284 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814007285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007286 Walker A/P-loop; other site 903814007287 ATP binding site [chemical binding]; other site 903814007288 Q-loop/lid; other site 903814007289 ABC transporter signature motif; other site 903814007290 Walker B; other site 903814007291 D-loop; other site 903814007292 H-loop/switch region; other site 903814007293 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814007294 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814007295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814007296 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 903814007297 Walker A/P-loop; other site 903814007298 ATP binding site [chemical binding]; other site 903814007299 Q-loop/lid; other site 903814007300 ABC transporter signature motif; other site 903814007301 Walker B; other site 903814007302 D-loop; other site 903814007303 H-loop/switch region; other site 903814007304 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814007305 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 903814007306 Walker A/P-loop; other site 903814007307 ATP binding site [chemical binding]; other site 903814007308 Q-loop/lid; other site 903814007309 ABC transporter signature motif; other site 903814007310 Walker B; other site 903814007311 D-loop; other site 903814007312 H-loop/switch region; other site 903814007313 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 903814007314 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 903814007315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814007316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814007317 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814007318 Walker A/P-loop; other site 903814007319 ATP binding site [chemical binding]; other site 903814007320 Q-loop/lid; other site 903814007321 ABC transporter signature motif; other site 903814007322 Walker B; other site 903814007323 D-loop; other site 903814007324 H-loop/switch region; other site 903814007325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814007326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814007327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007328 Walker A/P-loop; other site 903814007329 ATP binding site [chemical binding]; other site 903814007330 Q-loop/lid; other site 903814007331 ABC transporter signature motif; other site 903814007332 Walker B; other site 903814007333 D-loop; other site 903814007334 H-loop/switch region; other site 903814007335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814007336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814007337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 903814007338 dimerization interface [polypeptide binding]; other site 903814007339 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 903814007340 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814007341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814007342 putative substrate translocation pore; other site 903814007343 D-galactonate transporter; Region: 2A0114; TIGR00893 903814007344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814007345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814007346 putative substrate translocation pore; other site 903814007347 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814007348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814007349 DNA-binding site [nucleotide binding]; DNA binding site 903814007350 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814007351 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814007352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814007353 DNA-binding site [nucleotide binding]; DNA binding site 903814007354 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814007355 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814007356 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814007357 B12 binding site [chemical binding]; other site 903814007358 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814007359 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 903814007360 Walker A/P-loop; other site 903814007361 ATP binding site [chemical binding]; other site 903814007362 Q-loop/lid; other site 903814007363 ABC transporter signature motif; other site 903814007364 Walker B; other site 903814007365 D-loop; other site 903814007366 H-loop/switch region; other site 903814007367 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 903814007368 cobalt transport protein CbiN; Provisional; Region: PRK02898 903814007369 cobalt transport protein CbiM; Validated; Region: PRK08319 903814007370 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 903814007371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814007372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814007373 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814007374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 903814007375 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 903814007376 dimer interface [polypeptide binding]; other site 903814007377 active site 903814007378 metal binding site [ion binding]; metal-binding site 903814007379 glutathione binding site [chemical binding]; other site 903814007380 Recombination protein O N terminal; Region: RecO_N; pfam11967 903814007381 DNA repair protein RecO; Region: reco; TIGR00613 903814007382 Recombination protein O C terminal; Region: RecO_C; pfam02565 903814007383 GTPase Era; Reviewed; Region: era; PRK00089 903814007384 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 903814007385 G1 box; other site 903814007386 GTP/Mg2+ binding site [chemical binding]; other site 903814007387 Switch I region; other site 903814007388 G2 box; other site 903814007389 Switch II region; other site 903814007390 G3 box; other site 903814007391 G4 box; other site 903814007392 G5 box; other site 903814007393 KH domain; Region: KH_2; pfam07650 903814007394 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 903814007395 metal-binding heat shock protein; Provisional; Region: PRK00016 903814007396 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 903814007397 PhoH-like protein; Region: PhoH; pfam02562 903814007398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 903814007399 catalytic core [active] 903814007400 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814007401 EamA-like transporter family; Region: EamA; pfam00892 903814007402 EamA-like transporter family; Region: EamA; pfam00892 903814007403 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 903814007404 ADP-ribose binding site [chemical binding]; other site 903814007405 Predicted transcriptional regulators [Transcription]; Region: COG1733 903814007406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814007407 dimerization interface [polypeptide binding]; other site 903814007408 putative DNA binding site [nucleotide binding]; other site 903814007409 putative Zn2+ binding site [ion binding]; other site 903814007410 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 903814007411 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 903814007412 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 903814007413 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 903814007414 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 903814007415 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814007416 intersubunit interface [polypeptide binding]; other site 903814007417 active site 903814007418 zinc binding site [ion binding]; other site 903814007419 Na+ binding site [ion binding]; other site 903814007420 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 903814007421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814007422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814007423 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814007424 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814007425 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814007426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 903814007427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814007428 NAD(P) binding site [chemical binding]; other site 903814007429 active site 903814007430 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814007431 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 903814007432 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814007433 putative active site [active] 903814007434 MgATP binding site [chemical binding]; other site 903814007435 catalytic site [active] 903814007436 metal binding site [ion binding]; metal-binding site 903814007437 putative xylulose binding site [chemical binding]; other site 903814007438 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 903814007439 glycerol kinase; Provisional; Region: glpK; PRK00047 903814007440 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 903814007441 N- and C-terminal domain interface [polypeptide binding]; other site 903814007442 active site 903814007443 MgATP binding site [chemical binding]; other site 903814007444 catalytic site [active] 903814007445 metal binding site [ion binding]; metal-binding site 903814007446 glycerol binding site [chemical binding]; other site 903814007447 homotetramer interface [polypeptide binding]; other site 903814007448 homodimer interface [polypeptide binding]; other site 903814007449 FBP binding site [chemical binding]; other site 903814007450 protein IIAGlc interface [polypeptide binding]; other site 903814007451 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 903814007452 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 903814007453 metal binding site [ion binding]; metal-binding site 903814007454 hypothetical protein; Reviewed; Region: PRK12497 903814007455 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 903814007456 RNA/DNA hybrid binding site [nucleotide binding]; other site 903814007457 active site 903814007458 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 903814007459 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 903814007460 GTP/Mg2+ binding site [chemical binding]; other site 903814007461 G4 box; other site 903814007462 G5 box; other site 903814007463 G1 box; other site 903814007464 Switch I region; other site 903814007465 G2 box; other site 903814007466 G3 box; other site 903814007467 Switch II region; other site 903814007468 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 903814007469 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 903814007470 Catalytic site [active] 903814007471 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 903814007472 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814007473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814007474 Coenzyme A binding pocket [chemical binding]; other site 903814007475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 903814007476 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 903814007477 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 903814007478 RimM N-terminal domain; Region: RimM; pfam01782 903814007479 PRC-barrel domain; Region: PRC; pfam05239 903814007480 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 903814007481 hypothetical protein; Provisional; Region: PRK00468 903814007482 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 903814007483 signal recognition particle protein; Provisional; Region: PRK10867 903814007484 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 903814007485 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 903814007486 P loop; other site 903814007487 GTP binding site [chemical binding]; other site 903814007488 Signal peptide binding domain; Region: SRP_SPB; pfam02978 903814007489 putative DNA-binding protein; Validated; Region: PRK00118 903814007490 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 903814007491 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 903814007492 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814007493 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 903814007494 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 903814007495 Walker A/P-loop; other site 903814007496 ATP binding site [chemical binding]; other site 903814007497 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 903814007498 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 903814007499 Q-loop/lid; other site 903814007500 ABC transporter signature motif; other site 903814007501 Walker B; other site 903814007502 D-loop; other site 903814007503 H-loop/switch region; other site 903814007504 ribonuclease III; Reviewed; Region: rnc; PRK00102 903814007505 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 903814007506 dimerization interface [polypeptide binding]; other site 903814007507 active site 903814007508 metal binding site [ion binding]; metal-binding site 903814007509 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 903814007510 dsRNA binding site [nucleotide binding]; other site 903814007511 acyl carrier protein; Provisional; Region: acpP; PRK00982 903814007512 putative phosphate acyltransferase; Provisional; Region: PRK05331 903814007513 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 903814007514 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 903814007515 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 903814007516 propionate/acetate kinase; Provisional; Region: PRK12379 903814007517 hypothetical protein; Provisional; Region: PRK13670 903814007518 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 903814007519 Carboxylesterase family; Region: COesterase; pfam00135 903814007520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 903814007521 substrate binding pocket [chemical binding]; other site 903814007522 catalytic triad [active] 903814007523 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 903814007524 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 903814007525 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814007526 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 903814007527 ribonuclease R; Region: RNase_R; TIGR02063 903814007528 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 903814007529 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 903814007530 RNB domain; Region: RNB; pfam00773 903814007531 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 903814007532 RNA binding site [nucleotide binding]; other site 903814007533 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 903814007534 SmpB-tmRNA interface; other site 903814007535 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 903814007536 D5 N terminal like; Region: D5_N; smart00885 903814007537 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 903814007538 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 903814007539 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 903814007540 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 903814007541 ParA-like protein; Provisional; Region: PHA02518 903814007542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814007543 P-loop; other site 903814007544 Magnesium ion binding site [ion binding]; other site 903814007545 Methyltransferase domain; Region: Methyltransf_26; pfam13659 903814007546 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 903814007547 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 903814007548 T5orf172 domain; Region: T5orf172; pfam10544 903814007549 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 903814007550 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 903814007551 catalytic residues [active] 903814007552 catalytic nucleophile [active] 903814007553 Recombinase; Region: Recombinase; pfam07508 903814007554 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 903814007555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 903814007556 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814007557 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 903814007558 B12 binding site [chemical binding]; other site 903814007559 cobalt ligand [ion binding]; other site 903814007560 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814007561 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 903814007562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814007563 Helix-turn-helix domain; Region: HTH_18; pfam12833 903814007564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814007565 DctM-like transporters; Region: DctM; pfam06808 903814007566 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 903814007567 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 903814007568 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 903814007569 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 903814007570 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 903814007571 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 903814007572 Strictosidine synthase; Region: Str_synth; pfam03088 903814007573 L-fucose isomerase, C-terminal domain; Region: Fucose_iso_C; pfam02952 903814007574 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 903814007575 hexamer (dimer of trimers) interface [polypeptide binding]; other site 903814007576 trimer interface [polypeptide binding]; other site 903814007577 substrate binding site [chemical binding]; other site 903814007578 Mn binding site [ion binding]; other site 903814007579 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 903814007580 classical (c) SDRs; Region: SDR_c; cd05233 903814007581 NAD(P) binding site [chemical binding]; other site 903814007582 active site 903814007583 Creatinine amidohydrolase; Region: Creatininase; pfam02633 903814007584 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 903814007585 Transcriptional regulators [Transcription]; Region: PurR; COG1609 903814007586 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 903814007587 DNA binding site [nucleotide binding] 903814007588 domain linker motif; other site 903814007589 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 903814007590 putative dimerization interface [polypeptide binding]; other site 903814007591 putative ligand binding site [chemical binding]; other site 903814007592 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 903814007593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814007594 putative active site [active] 903814007595 PAS fold; Region: PAS_3; pfam08447 903814007596 heme pocket [chemical binding]; other site 903814007597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814007598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814007599 dimer interface [polypeptide binding]; other site 903814007600 phosphorylation site [posttranslational modification] 903814007601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814007602 ATP binding site [chemical binding]; other site 903814007603 Mg2+ binding site [ion binding]; other site 903814007604 G-X-G motif; other site 903814007605 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 903814007606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814007607 active site 903814007608 phosphorylation site [posttranslational modification] 903814007609 intermolecular recognition site; other site 903814007610 dimerization interface [polypeptide binding]; other site 903814007611 Response regulator receiver domain; Region: Response_reg; pfam00072 903814007612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814007613 active site 903814007614 phosphorylation site [posttranslational modification] 903814007615 intermolecular recognition site; other site 903814007616 dimerization interface [polypeptide binding]; other site 903814007617 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 903814007618 G1 box; other site 903814007619 GTP/Mg2+ binding site [chemical binding]; other site 903814007620 G2 box; other site 903814007621 G3 box; other site 903814007622 Switch II region; other site 903814007623 G4 box; other site 903814007624 G5 box; other site 903814007625 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 903814007626 putative hexamer interface [polypeptide binding]; other site 903814007627 putative hexagonal pore; other site 903814007628 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 903814007629 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 903814007630 Propanediol utilisation protein PduL; Region: PduL; pfam06130 903814007631 Propanediol utilisation protein PduL; Region: PduL; pfam06130 903814007632 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 903814007633 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 903814007634 Walker A/P-loop; other site 903814007635 ATP binding site [chemical binding]; other site 903814007636 Q-loop/lid; other site 903814007637 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 903814007638 ABC transporter signature motif; other site 903814007639 Walker B; other site 903814007640 D-loop; other site 903814007641 H-loop/switch region; other site 903814007642 arginine repressor; Provisional; Region: argR; PRK00441 903814007643 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 903814007644 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 903814007645 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 903814007646 ATP-NAD kinase; Region: NAD_kinase; pfam01513 903814007647 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 903814007648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814007649 RNA binding surface [nucleotide binding]; other site 903814007650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814007651 S-adenosylmethionine binding site [chemical binding]; other site 903814007652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814007653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814007654 putative substrate translocation pore; other site 903814007655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814007656 Predicted transcriptional regulators [Transcription]; Region: COG1695 903814007657 Transcriptional regulator PadR-like family; Region: PadR; cl17335 903814007658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814007659 non-specific DNA binding site [nucleotide binding]; other site 903814007660 salt bridge; other site 903814007661 sequence-specific DNA binding site [nucleotide binding]; other site 903814007662 recA bacterial DNA recombination protein; Region: RecA; cl17211 903814007663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814007664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814007665 non-specific DNA binding site [nucleotide binding]; other site 903814007666 salt bridge; other site 903814007667 sequence-specific DNA binding site [nucleotide binding]; other site 903814007668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 903814007669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 903814007670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 903814007671 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 903814007672 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 903814007673 trimer interface [polypeptide binding]; other site 903814007674 active site 903814007675 substrate binding site [chemical binding]; other site 903814007676 CoA binding site [chemical binding]; other site 903814007677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814007678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814007679 H+ Antiporter protein; Region: 2A0121; TIGR00900 903814007680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814007681 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 903814007682 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 903814007683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814007684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814007685 non-specific DNA binding site [nucleotide binding]; other site 903814007686 salt bridge; other site 903814007687 sequence-specific DNA binding site [nucleotide binding]; other site 903814007688 magnesium-transporting ATPase; Provisional; Region: PRK15122 903814007689 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 903814007690 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814007691 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814007692 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 903814007693 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814007694 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814007695 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 903814007696 SelR domain; Region: SelR; pfam01641 903814007697 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 903814007698 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 903814007699 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 903814007700 active site 903814007701 catalytic site [active] 903814007702 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 903814007703 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 903814007704 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814007705 catalytic Zn binding site [ion binding]; other site 903814007706 NAD(P) binding site [chemical binding]; other site 903814007707 structural Zn binding site [ion binding]; other site 903814007708 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 903814007709 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 903814007710 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 903814007711 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 903814007712 DNA binding site [nucleotide binding] 903814007713 catalytic residue [active] 903814007714 H2TH interface [polypeptide binding]; other site 903814007715 putative catalytic residues [active] 903814007716 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 903814007717 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 903814007718 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 903814007719 YcxB-like protein; Region: YcxB; pfam14317 903814007720 Methyltransferase domain; Region: Methyltransf_23; pfam13489 903814007721 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814007722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 903814007723 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814007724 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814007725 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 903814007726 Walker A/P-loop; other site 903814007727 ATP binding site [chemical binding]; other site 903814007728 Q-loop/lid; other site 903814007729 ABC transporter signature motif; other site 903814007730 Walker B; other site 903814007731 D-loop; other site 903814007732 H-loop/switch region; other site 903814007733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814007734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814007735 ATP binding site [chemical binding]; other site 903814007736 Mg2+ binding site [ion binding]; other site 903814007737 G-X-G motif; other site 903814007738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814007739 dimer interface [polypeptide binding]; other site 903814007740 phosphorylation site [posttranslational modification] 903814007741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814007742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814007743 active site 903814007744 phosphorylation site [posttranslational modification] 903814007745 intermolecular recognition site; other site 903814007746 dimerization interface [polypeptide binding]; other site 903814007747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814007748 DNA binding site [nucleotide binding] 903814007749 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 903814007750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814007751 FeS/SAM binding site; other site 903814007752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814007753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814007754 active site 903814007755 phosphorylation site [posttranslational modification] 903814007756 intermolecular recognition site; other site 903814007757 dimerization interface [polypeptide binding]; other site 903814007758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814007759 DNA binding site [nucleotide binding] 903814007760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814007761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814007762 dimer interface [polypeptide binding]; other site 903814007763 phosphorylation site [posttranslational modification] 903814007764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814007765 Mg2+ binding site [ion binding]; other site 903814007766 G-X-G motif; other site 903814007767 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814007768 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814007769 Walker A/P-loop; other site 903814007770 ATP binding site [chemical binding]; other site 903814007771 Q-loop/lid; other site 903814007772 ABC transporter signature motif; other site 903814007773 Walker B; other site 903814007774 D-loop; other site 903814007775 H-loop/switch region; other site 903814007776 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814007777 FtsX-like permease family; Region: FtsX; pfam02687 903814007778 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814007779 FtsX-like permease family; Region: FtsX; pfam02687 903814007780 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 903814007781 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 903814007782 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814007783 catalytic residue [active] 903814007784 Cupin domain; Region: Cupin_2; pfam07883 903814007785 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 903814007786 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814007787 DNA binding residues [nucleotide binding] 903814007788 drug binding residues [chemical binding]; other site 903814007789 dimer interface [polypeptide binding]; other site 903814007790 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 903814007791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814007792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814007793 Pathogenicity locus; Region: Cdd1; pfam11731 903814007794 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 903814007795 active site 903814007796 metal binding site [ion binding]; metal-binding site 903814007797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 903814007798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 903814007799 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 903814007800 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 903814007801 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 903814007802 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 903814007803 PhoU domain; Region: PhoU; pfam01895 903814007804 Predicted ATPase [General function prediction only]; Region: COG3910 903814007805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 903814007806 Walker A/P-loop; other site 903814007807 ATP binding site [chemical binding]; other site 903814007808 Q-loop/lid; other site 903814007809 ABC transporter signature motif; other site 903814007810 Walker B; other site 903814007811 D-loop; other site 903814007812 H-loop/switch region; other site 903814007813 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 903814007814 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 903814007815 DNA binding residues [nucleotide binding] 903814007816 drug binding residues [chemical binding]; other site 903814007817 dimer interface [polypeptide binding]; other site 903814007818 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 903814007819 TIR domain; Region: TIR_2; pfam13676 903814007820 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814007821 MarR family; Region: MarR; pfam01047 903814007822 MarR family; Region: MarR_2; cl17246 903814007823 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 903814007824 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 903814007825 catalytic triad [active] 903814007826 topology modulation protein; Provisional; Region: PRK07261 903814007827 AAA domain; Region: AAA_17; pfam13207 903814007828 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 903814007829 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 903814007830 RDD family; Region: RDD; pfam06271 903814007831 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814007832 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 903814007833 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814007834 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814007835 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814007836 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 903814007837 putative N- and C-terminal domain interface [polypeptide binding]; other site 903814007838 putative active site [active] 903814007839 MgATP binding site [chemical binding]; other site 903814007840 catalytic site [active] 903814007841 metal binding site [ion binding]; metal-binding site 903814007842 putative carbohydrate binding site [chemical binding]; other site 903814007843 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 903814007844 FAD binding domain; Region: FAD_binding_4; pfam01565 903814007845 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 903814007846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814007847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814007848 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 903814007849 NAD binding site [chemical binding]; other site 903814007850 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814007851 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814007852 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814007853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814007854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814007855 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 903814007856 Domain of unknown function DUF20; Region: UPF0118; pfam01594 903814007857 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814007858 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814007859 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814007860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814007861 Helix-turn-helix domain; Region: HTH_38; pfam13936 903814007862 BRO family, N-terminal domain; Region: Bro-N; pfam02498 903814007863 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 903814007864 RNA/DNA hybrid binding site [nucleotide binding]; other site 903814007865 active site 903814007866 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 903814007867 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 903814007868 HIGH motif; other site 903814007869 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 903814007870 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 903814007871 active site 903814007872 KMSKS motif; other site 903814007873 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 903814007874 tRNA binding surface [nucleotide binding]; other site 903814007875 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 903814007876 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 903814007877 dimer interface [polypeptide binding]; other site 903814007878 active site 903814007879 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 903814007880 substrate binding site [chemical binding]; other site 903814007881 catalytic residue [active] 903814007882 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814007883 EamA-like transporter family; Region: EamA; pfam00892 903814007884 EamA-like transporter family; Region: EamA; pfam00892 903814007885 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 903814007886 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 903814007887 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 903814007888 G1 box; other site 903814007889 GTP/Mg2+ binding site [chemical binding]; other site 903814007890 Switch I region; other site 903814007891 G2 box; other site 903814007892 G3 box; other site 903814007893 Switch II region; other site 903814007894 G4 box; other site 903814007895 G5 box; other site 903814007896 Nucleoside recognition; Region: Gate; pfam07670 903814007897 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 903814007898 Nucleoside recognition; Region: Gate; pfam07670 903814007899 FeoA domain; Region: FeoA; pfam04023 903814007900 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814007901 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 903814007902 LytTr DNA-binding domain; Region: LytTR; smart00850 903814007903 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 903814007904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 903814007905 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 903814007906 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 903814007907 excinuclease ABC subunit B; Provisional; Region: PRK05298 903814007908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814007909 ATP binding site [chemical binding]; other site 903814007910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814007911 nucleotide binding region [chemical binding]; other site 903814007912 ATP-binding site [chemical binding]; other site 903814007913 Ultra-violet resistance protein B; Region: UvrB; pfam12344 903814007914 UvrB/uvrC motif; Region: UVR; pfam02151 903814007915 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 903814007916 C-terminal peptidase (prc); Region: prc; TIGR00225 903814007917 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 903814007918 protein binding site [polypeptide binding]; other site 903814007919 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 903814007920 Catalytic dyad [active] 903814007921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 903814007922 Protein of unknown function (DUF904); Region: DUF904; cl11531 903814007923 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814007924 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814007925 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 903814007926 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 903814007927 FtsX-like permease family; Region: FtsX; pfam02687 903814007928 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 903814007929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814007930 Walker A/P-loop; other site 903814007931 ATP binding site [chemical binding]; other site 903814007932 Q-loop/lid; other site 903814007933 ABC transporter signature motif; other site 903814007934 Walker B; other site 903814007935 D-loop; other site 903814007936 H-loop/switch region; other site 903814007937 S-adenosylmethionine synthetase; Validated; Region: PRK05250 903814007938 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 903814007939 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 903814007940 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 903814007941 proline aminopeptidase P II; Provisional; Region: PRK10879 903814007942 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 903814007943 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 903814007944 active site 903814007945 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 903814007946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814007947 motif II; other site 903814007948 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814007949 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 903814007950 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 903814007951 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 903814007952 Ligand Binding Site [chemical binding]; other site 903814007953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814007954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814007955 active site 903814007956 phosphorylation site [posttranslational modification] 903814007957 intermolecular recognition site; other site 903814007958 dimerization interface [polypeptide binding]; other site 903814007959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814007960 DNA binding site [nucleotide binding] 903814007961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814007962 dimerization interface [polypeptide binding]; other site 903814007963 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 903814007964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814007965 dimer interface [polypeptide binding]; other site 903814007966 phosphorylation site [posttranslational modification] 903814007967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814007968 ATP binding site [chemical binding]; other site 903814007969 Mg2+ binding site [ion binding]; other site 903814007970 G-X-G motif; other site 903814007971 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 903814007972 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 903814007973 Domain of unknown function DUF21; Region: DUF21; pfam01595 903814007974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 903814007975 Transporter associated domain; Region: CorC_HlyC; smart01091 903814007976 pyruvate kinase; Provisional; Region: PRK06354 903814007977 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 903814007978 domain interfaces; other site 903814007979 active site 903814007980 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 903814007981 6-phosphofructokinase; Provisional; Region: PRK03202 903814007982 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 903814007983 active site 903814007984 ADP/pyrophosphate binding site [chemical binding]; other site 903814007985 dimerization interface [polypeptide binding]; other site 903814007986 allosteric effector site; other site 903814007987 fructose-1,6-bisphosphate binding site; other site 903814007988 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 903814007989 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 903814007990 active site 903814007991 PHP Thumb interface [polypeptide binding]; other site 903814007992 metal binding site [ion binding]; metal-binding site 903814007993 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 903814007994 generic binding surface II; other site 903814007995 generic binding surface I; other site 903814007996 Transcriptional regulator [Transcription]; Region: LytR; COG1316 903814007997 PHP domain; Region: PHP; pfam02811 903814007998 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 903814007999 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814008000 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 903814008001 Chain length determinant protein; Region: Wzz; cl15801 903814008002 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 903814008003 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 903814008004 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 903814008005 NAD(P) binding site [chemical binding]; other site 903814008006 homodimer interface [polypeptide binding]; other site 903814008007 substrate binding site [chemical binding]; other site 903814008008 active site 903814008009 Predicted integral membrane protein [Function unknown]; Region: COG5652 903814008010 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 903814008011 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 903814008012 putative active site [active] 903814008013 putative metal binding site [ion binding]; other site 903814008014 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 903814008015 active pocket/dimerization site; other site 903814008016 active site 903814008017 phosphorylation site [posttranslational modification] 903814008018 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 903814008019 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 903814008020 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 903814008021 glycerol kinase; Provisional; Region: glpK; PRK00047 903814008022 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 903814008023 N- and C-terminal domain interface [polypeptide binding]; other site 903814008024 active site 903814008025 MgATP binding site [chemical binding]; other site 903814008026 catalytic site [active] 903814008027 metal binding site [ion binding]; metal-binding site 903814008028 glycerol binding site [chemical binding]; other site 903814008029 homotetramer interface [polypeptide binding]; other site 903814008030 homodimer interface [polypeptide binding]; other site 903814008031 FBP binding site [chemical binding]; other site 903814008032 protein IIAGlc interface [polypeptide binding]; other site 903814008033 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 903814008034 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814008035 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814008036 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814008037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814008038 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 903814008039 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 903814008040 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 903814008041 HTH domain; Region: HTH_11; pfam08279 903814008042 3H domain; Region: 3H; pfam02829 903814008043 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 903814008044 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 903814008045 dimerization interface [polypeptide binding]; other site 903814008046 active site 903814008047 L-aspartate oxidase; Provisional; Region: PRK06175 903814008048 FAD binding domain; Region: FAD_binding_2; pfam00890 903814008049 Quinolinate synthetase A protein; Region: NadA; pfam02445 903814008050 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814008051 Phage lysis protein, holin; Region: Phage_holin; cl04675 903814008052 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 903814008053 Phage tail protein; Region: Sipho_tail; cl17486 903814008054 Phage-related minor tail protein [Function unknown]; Region: COG5280 903814008055 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 903814008056 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 903814008057 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 903814008058 oligomerization interface [polypeptide binding]; other site 903814008059 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 903814008060 Phage capsid family; Region: Phage_capsid; pfam05065 903814008061 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 903814008062 Phage-related protein [Function unknown]; Region: COG4695; cl01923 903814008063 Phage portal protein; Region: Phage_portal; pfam04860 903814008064 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 903814008065 Phage terminase, small subunit; Region: Terminase_4; pfam05119 903814008066 AP2 domain; Region: AP2; pfam00847 903814008067 Recombination protein U; Region: RecU; cl01314 903814008068 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 903814008069 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 903814008070 cofactor binding site; other site 903814008071 DNA binding site [nucleotide binding] 903814008072 substrate interaction site [chemical binding]; other site 903814008073 Helix-turn-helix domain; Region: HTH_17; cl17695 903814008074 AntA/AntB antirepressor; Region: AntA; pfam08346 903814008075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008076 non-specific DNA binding site [nucleotide binding]; other site 903814008077 salt bridge; other site 903814008078 sequence-specific DNA binding site [nucleotide binding]; other site 903814008079 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 903814008080 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 903814008081 active site 903814008082 catalytic site [active] 903814008083 substrate binding site [chemical binding]; other site 903814008084 YcfA-like protein; Region: YcfA; pfam07927 903814008085 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 903814008086 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 903814008087 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814008088 Int/Topo IB signature motif; other site 903814008089 aspartate kinase; Reviewed; Region: PRK06635 903814008090 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 903814008091 putative catalytic residues [active] 903814008092 putative nucleotide binding site [chemical binding]; other site 903814008093 putative aspartate binding site [chemical binding]; other site 903814008094 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 903814008095 putative allosteric regulatory site; other site 903814008096 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 903814008097 putative allosteric regulatory residue; other site 903814008098 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 903814008099 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 903814008100 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 903814008101 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 903814008102 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 903814008103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814008104 catalytic residue [active] 903814008105 homoserine kinase; Provisional; Region: PRK01212 903814008106 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 903814008107 hypothetical protein; Provisional; Region: PRK04435 903814008108 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 903814008109 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 903814008110 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 903814008111 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814008112 transmembrane helices; other site 903814008113 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814008114 MFS/sugar transport protein; Region: MFS_2; pfam13347 903814008115 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 903814008116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814008117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814008118 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 903814008119 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 903814008120 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 903814008121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 903814008122 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814008123 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 903814008124 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 903814008125 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 903814008126 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 903814008127 metal binding site [ion binding]; metal-binding site 903814008128 dimer interface [polypeptide binding]; other site 903814008129 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 903814008130 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 903814008131 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 903814008132 catalytic triad [active] 903814008133 putative active site [active] 903814008134 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 903814008135 catalytic residues [active] 903814008136 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 903814008137 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814008138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814008139 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 903814008140 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 903814008141 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814008142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814008144 non-specific DNA binding site [nucleotide binding]; other site 903814008145 salt bridge; other site 903814008146 sequence-specific DNA binding site [nucleotide binding]; other site 903814008147 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 903814008148 HicB family; Region: HicB; pfam05534 903814008149 YcfA-like protein; Region: YcfA; cl00752 903814008150 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 903814008151 active site 903814008152 metal binding site [ion binding]; metal-binding site 903814008153 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814008154 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814008155 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 903814008156 Phage tail protein; Region: Sipho_tail; cl17486 903814008157 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 903814008158 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814008159 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814008160 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 903814008161 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 903814008162 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 903814008163 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 903814008164 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 903814008165 oligomerization interface [polypeptide binding]; other site 903814008166 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 903814008167 Phage capsid family; Region: Phage_capsid; pfam05065 903814008168 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 903814008169 Phage portal protein; Region: Phage_portal; pfam04860 903814008170 Phage-related protein [Function unknown]; Region: COG4695; cl01923 903814008171 Phage Terminase; Region: Terminase_1; pfam03354 903814008172 Phage terminase, small subunit; Region: Terminase_4; cl01525 903814008173 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 903814008174 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 903814008175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 903814008176 Domain of unknown function (DUF927); Region: DUF927; cl12098 903814008177 CHC2 zinc finger; Region: zf-CHC2; cl17510 903814008178 AAA domain; Region: AAA_24; pfam13479 903814008179 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 903814008180 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 903814008181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814008183 non-specific DNA binding site [nucleotide binding]; other site 903814008184 salt bridge; other site 903814008185 sequence-specific DNA binding site [nucleotide binding]; other site 903814008186 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 903814008187 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 903814008188 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 903814008189 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 903814008190 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 903814008191 catalytic residues [active] 903814008192 catalytic nucleophile [active] 903814008193 Recombinase; Region: Recombinase; pfam07508 903814008194 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 903814008195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814008197 non-specific DNA binding site [nucleotide binding]; other site 903814008198 salt bridge; other site 903814008199 sequence-specific DNA binding site [nucleotide binding]; other site 903814008200 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 903814008201 HicB family; Region: HicB; pfam05534 903814008202 YcfA-like protein; Region: YcfA; cl00752 903814008203 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 903814008204 active site 903814008205 metal binding site [ion binding]; metal-binding site 903814008206 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814008207 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 903814008208 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 903814008209 Phage tail protein; Region: Sipho_tail; cl17486 903814008210 Mu-like prophage protein [General function prediction only]; Region: COG3941 903814008211 tape measure domain; Region: tape_meas_nterm; TIGR02675 903814008212 Phage-related protein [Function unknown]; Region: COG5412 903814008213 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 903814008214 Peptidase family M23; Region: Peptidase_M23; pfam01551 903814008215 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 903814008216 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 903814008217 Minor capsid protein; Region: Minor_capsid_2; pfam11114 903814008218 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 903814008219 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 903814008220 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 903814008221 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 903814008222 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 903814008223 Phage terminase large subunit; Region: Terminase_3; cl12054 903814008224 Terminase-like family; Region: Terminase_6; pfam03237 903814008225 Homeodomain-like domain; Region: HTH_23; pfam13384 903814008226 Terminase small subunit; Region: Terminase_2; pfam03592 903814008227 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 903814008228 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 903814008229 Recombination protein U; Region: RecU; cl01314 903814008230 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 903814008231 polymerase nucleotide-binding site; other site 903814008232 DNA-binding residues [nucleotide binding]; DNA binding site 903814008233 nucleotide binding site [chemical binding]; other site 903814008234 primase nucleotide-binding site [nucleotide binding]; other site 903814008235 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 903814008236 Domain of unknown function (DUF927); Region: DUF927; cl12098 903814008237 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 903814008238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 903814008239 ATP binding site [chemical binding]; other site 903814008240 putative Mg++ binding site [ion binding]; other site 903814008241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814008242 nucleotide binding region [chemical binding]; other site 903814008243 ATP-binding site [chemical binding]; other site 903814008244 Helix-turn-helix domain; Region: HTH_17; pfam12728 903814008245 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 903814008246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008247 non-specific DNA binding site [nucleotide binding]; other site 903814008248 salt bridge; other site 903814008249 sequence-specific DNA binding site [nucleotide binding]; other site 903814008250 AAA domain; Region: AAA_21; pfam13304 903814008251 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 903814008252 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 903814008253 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814008254 Int/Topo IB signature motif; other site 903814008255 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 903814008256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814008257 S-adenosylmethionine binding site [chemical binding]; other site 903814008258 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 903814008259 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 903814008260 metal binding site [ion binding]; metal-binding site 903814008261 dimer interface [polypeptide binding]; other site 903814008262 transcriptional antiterminator BglG; Provisional; Region: PRK09772 903814008263 CAT RNA binding domain; Region: CAT_RBD; smart01061 903814008264 PRD domain; Region: PRD; pfam00874 903814008265 PRD domain; Region: PRD; pfam00874 903814008266 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 903814008267 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 903814008268 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 903814008269 active site turn [active] 903814008270 phosphorylation site [posttranslational modification] 903814008271 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 903814008272 HPr interaction site; other site 903814008273 glycerol kinase (GK) interaction site [polypeptide binding]; other site 903814008274 active site 903814008275 phosphorylation site [posttranslational modification] 903814008276 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 903814008277 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 903814008278 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 903814008279 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 903814008280 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 903814008281 dimer interface [polypeptide binding]; other site 903814008282 active site 903814008283 catalytic residue [active] 903814008284 dihydrodipicolinate reductase; Provisional; Region: PRK00048 903814008285 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 903814008286 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 903814008287 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 903814008288 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 903814008289 trimer interface [polypeptide binding]; other site 903814008290 active site 903814008291 substrate binding site [chemical binding]; other site 903814008292 CoA binding site [chemical binding]; other site 903814008293 aspartate kinase; Reviewed; Region: PRK06635 903814008294 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 903814008295 putative nucleotide binding site [chemical binding]; other site 903814008296 putative catalytic residues [active] 903814008297 putative Mg ion binding site [ion binding]; other site 903814008298 putative aspartate binding site [chemical binding]; other site 903814008299 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 903814008300 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 903814008301 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 903814008302 putative allosteric regulatory site; other site 903814008303 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 903814008304 putative allosteric regulatory residue; other site 903814008305 Predicted transcriptional regulator [Transcription]; Region: COG2378 903814008306 HTH domain; Region: HTH_11; pfam08279 903814008307 WYL domain; Region: WYL; pfam13280 903814008308 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 903814008309 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 903814008310 conserved cys residue [active] 903814008311 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814008312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008313 non-specific DNA binding site [nucleotide binding]; other site 903814008314 salt bridge; other site 903814008315 sequence-specific DNA binding site [nucleotide binding]; other site 903814008316 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 903814008317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814008318 FtsX-like permease family; Region: FtsX; pfam02687 903814008319 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814008320 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814008321 FtsX-like permease family; Region: FtsX; pfam02687 903814008322 potential frameshift: common BLAST hit: gi|310829383|ref|YP_003961740.1| transcriptional regulator 903814008323 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 903814008324 Transcriptional regulator [Transcription]; Region: LytR; COG1316 903814008325 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 903814008326 active site 903814008327 Peptidase M30; Region: Peptidase_M30; pfam10460 903814008328 Fn3 associated; Region: Fn3_assoc; pfam13287 903814008329 CAAX protease self-immunity; Region: Abi; pfam02517 903814008330 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 903814008331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814008332 ATP binding site [chemical binding]; other site 903814008333 Mg2+ binding site [ion binding]; other site 903814008334 G-X-G motif; other site 903814008335 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814008336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008337 active site 903814008338 phosphorylation site [posttranslational modification] 903814008339 intermolecular recognition site; other site 903814008340 dimerization interface [polypeptide binding]; other site 903814008341 LytTr DNA-binding domain; Region: LytTR; smart00850 903814008342 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 903814008343 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 903814008344 active site 903814008345 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 903814008346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814008347 Walker A/P-loop; other site 903814008348 ATP binding site [chemical binding]; other site 903814008349 Q-loop/lid; other site 903814008350 ABC transporter signature motif; other site 903814008351 Walker B; other site 903814008352 D-loop; other site 903814008353 H-loop/switch region; other site 903814008354 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 903814008355 metal binding site 2 [ion binding]; metal-binding site 903814008356 putative DNA binding helix; other site 903814008357 metal binding site 1 [ion binding]; metal-binding site 903814008358 structural Zn2+ binding site [ion binding]; other site 903814008359 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 903814008360 MutS domain III; Region: MutS_III; pfam05192 903814008361 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 903814008362 Walker A/P-loop; other site 903814008363 ATP binding site [chemical binding]; other site 903814008364 Q-loop/lid; other site 903814008365 ABC transporter signature motif; other site 903814008366 Walker B; other site 903814008367 D-loop; other site 903814008368 H-loop/switch region; other site 903814008369 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 903814008370 Smr domain; Region: Smr; pfam01713 903814008371 putative protease; Provisional; Region: PRK15452 903814008372 Peptidase family U32; Region: Peptidase_U32; pfam01136 903814008373 Collagenase; Region: DUF3656; pfam12392 903814008374 Peptidase family U32; Region: Peptidase_U32; cl03113 903814008375 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 903814008376 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 903814008377 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 903814008378 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 903814008379 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 903814008380 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 903814008381 Peptidase M16C associated; Region: M16C_assoc; pfam08367 903814008382 recombination factor protein RarA; Reviewed; Region: PRK13342 903814008383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814008384 Walker A motif; other site 903814008385 ATP binding site [chemical binding]; other site 903814008386 Walker B motif; other site 903814008387 arginine finger; other site 903814008388 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 903814008389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814008390 S-adenosylmethionine binding site [chemical binding]; other site 903814008391 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 903814008392 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 903814008393 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 903814008394 dimer interface [polypeptide binding]; other site 903814008395 active site 903814008396 glycine-pyridoxal phosphate binding site [chemical binding]; other site 903814008397 folate binding site [chemical binding]; other site 903814008398 seryl-tRNA synthetase; Provisional; Region: PRK05431 903814008399 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 903814008400 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 903814008401 motif 1; other site 903814008402 dimer interface [polypeptide binding]; other site 903814008403 active site 903814008404 motif 2; other site 903814008405 motif 3; other site 903814008406 Response regulator receiver domain; Region: Response_reg; pfam00072 903814008407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008408 active site 903814008409 phosphorylation site [posttranslational modification] 903814008410 intermolecular recognition site; other site 903814008411 dimerization interface [polypeptide binding]; other site 903814008412 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814008413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814008414 metal binding site [ion binding]; metal-binding site 903814008415 active site 903814008416 I-site; other site 903814008417 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 903814008418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814008419 active site 903814008420 motif I; other site 903814008421 motif II; other site 903814008422 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814008423 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814008424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814008425 metal binding site [ion binding]; metal-binding site 903814008426 active site 903814008427 I-site; other site 903814008428 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 903814008429 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 903814008430 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 903814008431 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 903814008432 catalytic loop [active] 903814008433 iron binding site [ion binding]; other site 903814008434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814008435 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 903814008436 4Fe-4S binding domain; Region: Fer4; pfam00037 903814008437 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 903814008438 molybdopterin cofactor binding site; other site 903814008439 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 903814008440 dimer interface [polypeptide binding]; other site 903814008441 [2Fe-2S] cluster binding site [ion binding]; other site 903814008442 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 903814008443 SLBB domain; Region: SLBB; pfam10531 903814008444 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 903814008445 4Fe-4S binding domain; Region: Fer4; pfam00037 903814008446 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814008447 4Fe-4S binding domain; Region: Fer4; pfam00037 903814008448 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 903814008449 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 903814008450 putative dimer interface [polypeptide binding]; other site 903814008451 [2Fe-2S] cluster binding site [ion binding]; other site 903814008452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814008453 EamA-like transporter family; Region: EamA; pfam00892 903814008454 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 903814008455 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 903814008456 putative valine binding site [chemical binding]; other site 903814008457 dimer interface [polypeptide binding]; other site 903814008458 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 903814008459 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 903814008460 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 903814008461 PYR/PP interface [polypeptide binding]; other site 903814008462 dimer interface [polypeptide binding]; other site 903814008463 TPP binding site [chemical binding]; other site 903814008464 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 903814008465 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 903814008466 TPP-binding site [chemical binding]; other site 903814008467 Uncharacterized conserved protein [Function unknown]; Region: COG2006 903814008468 Domain of unknown function (DUF362); Region: DUF362; pfam04015 903814008469 Ferredoxin [Energy production and conversion]; Region: COG1146 903814008470 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814008471 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 903814008472 S1 domain; Region: S1_2; pfam13509 903814008473 S1 domain; Region: S1_2; pfam13509 903814008474 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 903814008475 RNA binding site [nucleotide binding]; other site 903814008476 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 903814008477 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 903814008478 active site 903814008479 (T/H)XGH motif; other site 903814008480 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 903814008481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814008482 S-adenosylmethionine binding site [chemical binding]; other site 903814008483 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 903814008484 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 903814008485 ssDNA binding site; other site 903814008486 generic binding surface II; other site 903814008487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814008488 ATP binding site [chemical binding]; other site 903814008489 putative Mg++ binding site [ion binding]; other site 903814008490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814008491 nucleotide binding region [chemical binding]; other site 903814008492 ATP-binding site [chemical binding]; other site 903814008493 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 903814008494 DAK2 domain; Region: Dak2; pfam02734 903814008495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 903814008496 Thiamine pyrophosphokinase; Region: TPK; cd07995 903814008497 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 903814008498 active site 903814008499 dimerization interface [polypeptide binding]; other site 903814008500 thiamine binding site [chemical binding]; other site 903814008501 GTPase RsgA; Reviewed; Region: PRK00098 903814008502 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 903814008503 RNA binding site [nucleotide binding]; other site 903814008504 homodimer interface [polypeptide binding]; other site 903814008505 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 903814008506 GTPase/Zn-binding domain interface [polypeptide binding]; other site 903814008507 GTP/Mg2+ binding site [chemical binding]; other site 903814008508 G4 box; other site 903814008509 G5 box; other site 903814008510 G1 box; other site 903814008511 Switch I region; other site 903814008512 G2 box; other site 903814008513 G3 box; other site 903814008514 Switch II region; other site 903814008515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 903814008516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 903814008517 active site 903814008518 ATP binding site [chemical binding]; other site 903814008519 substrate binding site [chemical binding]; other site 903814008520 activation loop (A-loop); other site 903814008521 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 903814008522 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 903814008523 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 903814008524 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 903814008525 active site 903814008526 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 903814008527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814008528 FeS/SAM binding site; other site 903814008529 16S rRNA methyltransferase B; Provisional; Region: PRK14902 903814008530 NusB family; Region: NusB; pfam01029 903814008531 putative RNA binding site [nucleotide binding]; other site 903814008532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814008533 S-adenosylmethionine binding site [chemical binding]; other site 903814008534 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 903814008535 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 903814008536 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 903814008537 putative active site [active] 903814008538 substrate binding site [chemical binding]; other site 903814008539 putative cosubstrate binding site; other site 903814008540 catalytic site [active] 903814008541 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 903814008542 substrate binding site [chemical binding]; other site 903814008543 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 903814008544 active site 903814008545 catalytic residues [active] 903814008546 metal binding site [ion binding]; metal-binding site 903814008547 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 903814008548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 903814008549 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 903814008550 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 903814008551 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 903814008552 catalytic site [active] 903814008553 G-X2-G-X-G-K; other site 903814008554 hypothetical protein; Provisional; Region: PRK11820 903814008555 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 903814008556 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 903814008557 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 903814008558 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 903814008559 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 903814008560 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 903814008561 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 903814008562 Domain of unknown function (DUF814); Region: DUF814; pfam05670 903814008563 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 903814008564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814008565 RNA binding surface [nucleotide binding]; other site 903814008566 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 903814008567 active site 903814008568 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 903814008569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814008570 RNA binding surface [nucleotide binding]; other site 903814008571 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814008572 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 903814008573 YGGT family; Region: YGGT; pfam02325 903814008574 Protein of unknown function (DUF552); Region: DUF552; pfam04472 903814008575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 903814008576 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 903814008577 catalytic residue [active] 903814008578 HlyD family secretion protein; Region: HlyD_2; pfam12700 903814008579 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 903814008580 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814008581 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 903814008582 putative ligand binding site [chemical binding]; other site 903814008583 putative NAD binding site [chemical binding]; other site 903814008584 catalytic site [active] 903814008585 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 903814008586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814008587 dimerization interface [polypeptide binding]; other site 903814008588 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 903814008589 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 903814008590 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 903814008591 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 903814008592 putative homodimer interface [polypeptide binding]; other site 903814008593 putative homotetramer interface [polypeptide binding]; other site 903814008594 putative metal binding site [ion binding]; other site 903814008595 putative homodimer-homodimer interface [polypeptide binding]; other site 903814008596 putative allosteric switch controlling residues; other site 903814008597 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814008598 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 903814008599 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 903814008600 dimer interface [polypeptide binding]; other site 903814008601 substrate binding site [chemical binding]; other site 903814008602 ATP binding site [chemical binding]; other site 903814008603 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 903814008604 thiamine phosphate binding site [chemical binding]; other site 903814008605 active site 903814008606 pyrophosphate binding site [ion binding]; other site 903814008607 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 903814008608 substrate binding site [chemical binding]; other site 903814008609 multimerization interface [polypeptide binding]; other site 903814008610 ATP binding site [chemical binding]; other site 903814008611 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 903814008612 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 903814008613 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 903814008614 Bacterial Ig-like domain; Region: Big_5; pfam13205 903814008615 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 903814008616 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 903814008617 catalytic triad [active] 903814008618 hypothetical protein; Provisional; Region: PRK09609 903814008619 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 903814008620 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 903814008621 homodecamer interface [polypeptide binding]; other site 903814008622 GTP cyclohydrolase I; Provisional; Region: PLN03044 903814008623 active site 903814008624 putative catalytic site residues [active] 903814008625 zinc binding site [ion binding]; other site 903814008626 GTP-CH-I/GFRP interaction surface; other site 903814008627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814008628 Zn2+ binding site [ion binding]; other site 903814008629 Mg2+ binding site [ion binding]; other site 903814008630 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 903814008631 dihydropteroate synthase; Region: DHPS; TIGR01496 903814008632 substrate binding pocket [chemical binding]; other site 903814008633 dimer interface [polypeptide binding]; other site 903814008634 inhibitor binding site; inhibition site 903814008635 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 903814008636 homooctamer interface [polypeptide binding]; other site 903814008637 active site 903814008638 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 903814008639 catalytic center binding site [active] 903814008640 ATP binding site [chemical binding]; other site 903814008641 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 903814008642 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814008643 intersubunit interface [polypeptide binding]; other site 903814008644 active site 903814008645 zinc binding site [ion binding]; other site 903814008646 Na+ binding site [ion binding]; other site 903814008647 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 903814008648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814008649 RNA binding surface [nucleotide binding]; other site 903814008650 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 903814008651 active site 903814008652 Recombination protein U; Region: RecU; pfam03838 903814008653 S-ribosylhomocysteinase; Provisional; Region: PRK02260 903814008654 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 903814008655 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 903814008656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814008657 FeS/SAM binding site; other site 903814008658 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 903814008659 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 903814008660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814008661 FeS/SAM binding site; other site 903814008662 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 903814008663 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 903814008664 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 903814008665 G1 box; other site 903814008666 GTP/Mg2+ binding site [chemical binding]; other site 903814008667 Switch I region; other site 903814008668 G2 box; other site 903814008669 Switch II region; other site 903814008670 G3 box; other site 903814008671 G4 box; other site 903814008672 G5 box; other site 903814008673 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814008674 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814008675 metal binding site [ion binding]; metal-binding site 903814008676 active site 903814008677 I-site; other site 903814008678 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814008679 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 903814008680 Protein of unknown function DUF45; Region: DUF45; pfam01863 903814008681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814008682 S-adenosylmethionine binding site [chemical binding]; other site 903814008683 C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains; Region: AMPKA_C_like; cl17070 903814008684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814008685 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 903814008686 Na2 binding site [ion binding]; other site 903814008687 putative substrate binding site 1 [chemical binding]; other site 903814008688 Na binding site 1 [ion binding]; other site 903814008689 putative substrate binding site 2 [chemical binding]; other site 903814008690 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 903814008691 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 903814008692 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 903814008693 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 903814008694 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 903814008695 active site 903814008696 metal binding site [ion binding]; metal-binding site 903814008697 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 903814008698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814008699 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 903814008700 FtsX-like permease family; Region: FtsX; pfam02687 903814008701 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814008702 FtsX-like permease family; Region: FtsX; pfam02687 903814008703 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814008704 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814008705 Walker A/P-loop; other site 903814008706 ATP binding site [chemical binding]; other site 903814008707 Q-loop/lid; other site 903814008708 ABC transporter signature motif; other site 903814008709 Walker B; other site 903814008710 D-loop; other site 903814008711 H-loop/switch region; other site 903814008712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814008713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814008714 dimer interface [polypeptide binding]; other site 903814008715 phosphorylation site [posttranslational modification] 903814008716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814008717 ATP binding site [chemical binding]; other site 903814008718 Mg2+ binding site [ion binding]; other site 903814008719 G-X-G motif; other site 903814008720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814008721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008722 active site 903814008723 phosphorylation site [posttranslational modification] 903814008724 intermolecular recognition site; other site 903814008725 dimerization interface [polypeptide binding]; other site 903814008726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814008727 DNA binding site [nucleotide binding] 903814008728 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 903814008729 anti sigma factor interaction site; other site 903814008730 regulatory phosphorylation site [posttranslational modification]; other site 903814008731 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 903814008732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 903814008733 Condensation domain; Region: Condensation; pfam00668 903814008734 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 903814008735 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 903814008736 acyl-activating enzyme (AAE) consensus motif; other site 903814008737 AMP binding site [chemical binding]; other site 903814008738 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 903814008739 Condensation domain; Region: Condensation; pfam00668 903814008740 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 903814008741 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 903814008742 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 903814008743 acyl-activating enzyme (AAE) consensus motif; other site 903814008744 AMP binding site [chemical binding]; other site 903814008745 thioester reductase domain; Region: Thioester-redct; TIGR01746 903814008746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814008747 NAD(P) binding site [chemical binding]; other site 903814008748 active site 903814008749 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 903814008750 HAMP domain; Region: HAMP; pfam00672 903814008751 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 903814008752 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 903814008753 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814008754 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814008755 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 903814008756 Response regulator receiver domain; Region: Response_reg; pfam00072 903814008757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008758 active site 903814008759 phosphorylation site [posttranslational modification] 903814008760 intermolecular recognition site; other site 903814008761 dimerization interface [polypeptide binding]; other site 903814008762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814008763 metal binding site [ion binding]; metal-binding site 903814008764 active site 903814008765 I-site; other site 903814008766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814008767 Response regulator receiver domain; Region: Response_reg; pfam00072 903814008768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008769 active site 903814008770 intermolecular recognition site; other site 903814008771 dimerization interface [polypeptide binding]; other site 903814008772 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814008773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814008774 metal binding site [ion binding]; metal-binding site 903814008775 active site 903814008776 I-site; other site 903814008777 Catalytic domain of Protein Kinases; Region: PKc; cd00180 903814008778 active site 903814008779 ATP binding site [chemical binding]; other site 903814008780 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 903814008781 substrate binding site [chemical binding]; other site 903814008782 activation loop (A-loop); other site 903814008783 AAA ATPase domain; Region: AAA_16; pfam13191 903814008784 Predicted ATPase [General function prediction only]; Region: COG3899 903814008785 Walker B motif; other site 903814008786 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 903814008787 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 903814008788 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814008789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814008790 metal binding site [ion binding]; metal-binding site 903814008791 active site 903814008792 I-site; other site 903814008793 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814008794 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 903814008795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814008796 putative active site [active] 903814008797 heme pocket [chemical binding]; other site 903814008798 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 903814008799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814008800 putative active site [active] 903814008801 heme pocket [chemical binding]; other site 903814008802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814008803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814008804 dimer interface [polypeptide binding]; other site 903814008805 phosphorylation site [posttranslational modification] 903814008806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814008807 ATP binding site [chemical binding]; other site 903814008808 Mg2+ binding site [ion binding]; other site 903814008809 G-X-G motif; other site 903814008810 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 903814008811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008812 active site 903814008813 phosphorylation site [posttranslational modification] 903814008814 intermolecular recognition site; other site 903814008815 dimerization interface [polypeptide binding]; other site 903814008816 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 903814008817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008818 active site 903814008819 phosphorylation site [posttranslational modification] 903814008820 intermolecular recognition site; other site 903814008821 dimerization interface [polypeptide binding]; other site 903814008822 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 903814008823 putative binding surface; other site 903814008824 active site 903814008825 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 903814008826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814008827 Radical SAM superfamily; Region: Radical_SAM; pfam04055 903814008828 FeS/SAM binding site; other site 903814008829 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 903814008830 N- and C-terminal domain interface [polypeptide binding]; other site 903814008831 D-xylulose kinase; Region: XylB; TIGR01312 903814008832 active site 903814008833 MgATP binding site [chemical binding]; other site 903814008834 catalytic site [active] 903814008835 metal binding site [ion binding]; metal-binding site 903814008836 xylulose binding site [chemical binding]; other site 903814008837 homodimer interface [polypeptide binding]; other site 903814008838 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 903814008839 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 903814008840 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 903814008841 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814008842 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 903814008843 putative switch regulator; other site 903814008844 DNA binding site [nucleotide binding] 903814008845 sequence specific DNA binding site [nucleotide binding]; other site 903814008846 putative cAMP binding site [chemical binding]; other site 903814008847 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814008848 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 903814008849 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 903814008850 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814008851 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 903814008852 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 903814008853 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 903814008854 G1 box; other site 903814008855 GTP/Mg2+ binding site [chemical binding]; other site 903814008856 Switch I region; other site 903814008857 G2 box; other site 903814008858 G3 box; other site 903814008859 Switch II region; other site 903814008860 G4 box; other site 903814008861 G5 box; other site 903814008862 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 903814008863 Nucleoside recognition; Region: Gate; pfam07670 903814008864 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 903814008865 Nucleoside recognition; Region: Gate; pfam07670 903814008866 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814008867 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814008868 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814008869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814008870 Helix-turn-helix domain; Region: HTH_38; pfam13936 903814008871 BRO family, N-terminal domain; Region: Bro-N; smart01040 903814008872 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814008873 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814008874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008875 active site 903814008876 phosphorylation site [posttranslational modification] 903814008877 intermolecular recognition site; other site 903814008878 dimerization interface [polypeptide binding]; other site 903814008879 LytTr DNA-binding domain; Region: LytTR; pfam04397 903814008880 Amino acid permease; Region: AA_permease_2; pfam13520 903814008881 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 903814008882 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 903814008883 active site 903814008884 metal binding site [ion binding]; metal-binding site 903814008885 SipW-cognate class signal peptide; Region: cognate_SipW; TIGR04088 903814008886 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 903814008887 Catalytic site [active] 903814008888 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 903814008889 metal ion-dependent adhesion site (MIDAS); other site 903814008890 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 903814008891 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 903814008892 Int/Topo IB signature motif; other site 903814008893 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 903814008894 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 903814008895 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 903814008896 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 903814008897 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 903814008898 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 903814008899 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 903814008900 TPP-binding site [chemical binding]; other site 903814008901 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 903814008902 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 903814008903 dimer interface [polypeptide binding]; other site 903814008904 PYR/PP interface [polypeptide binding]; other site 903814008905 TPP binding site [chemical binding]; other site 903814008906 substrate binding site [chemical binding]; other site 903814008907 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814008908 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 903814008909 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814008910 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 903814008911 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 903814008912 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 903814008913 NAD binding site [chemical binding]; other site 903814008914 Phe binding site; other site 903814008915 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 903814008916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814008917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814008918 non-specific DNA binding site [nucleotide binding]; other site 903814008919 salt bridge; other site 903814008920 sequence-specific DNA binding site [nucleotide binding]; other site 903814008921 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 903814008922 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814008923 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814008924 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814008925 Walker A/P-loop; other site 903814008926 ATP binding site [chemical binding]; other site 903814008927 Q-loop/lid; other site 903814008928 ABC transporter signature motif; other site 903814008929 Walker B; other site 903814008930 D-loop; other site 903814008931 H-loop/switch region; other site 903814008932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814008933 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814008934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814008935 Walker A/P-loop; other site 903814008936 ATP binding site [chemical binding]; other site 903814008937 Q-loop/lid; other site 903814008938 ABC transporter signature motif; other site 903814008939 Walker B; other site 903814008940 D-loop; other site 903814008941 H-loop/switch region; other site 903814008942 Transcriptional regulators [Transcription]; Region: MarR; COG1846 903814008943 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 903814008944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814008945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814008946 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814008947 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 903814008948 putative active site [active] 903814008949 catalytic residue [active] 903814008950 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 903814008951 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 903814008952 dimer interface [polypeptide binding]; other site 903814008953 active site 903814008954 metal binding site [ion binding]; metal-binding site 903814008955 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 903814008956 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 903814008957 active site 903814008958 metal binding site [ion binding]; metal-binding site 903814008959 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 903814008960 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 903814008961 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 903814008962 ligand binding site [chemical binding]; other site 903814008963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 903814008964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814008965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814008966 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 903814008967 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 903814008968 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 903814008969 PhoU domain; Region: PhoU; pfam01895 903814008970 PhoU domain; Region: PhoU; pfam01895 903814008971 glycyl-tRNA synthetase; Provisional; Region: PRK04173 903814008972 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 903814008973 motif 1; other site 903814008974 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 903814008975 active site 903814008976 motif 2; other site 903814008977 motif 3; other site 903814008978 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 903814008979 anticodon binding site; other site 903814008980 TfoX C-terminal domain; Region: TfoX_C; pfam04994 903814008981 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 903814008982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 903814008983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 903814008984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 903814008985 active site residue [active] 903814008986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814008987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814008988 active site 903814008989 phosphorylation site [posttranslational modification] 903814008990 intermolecular recognition site; other site 903814008991 dimerization interface [polypeptide binding]; other site 903814008992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814008993 DNA binding site [nucleotide binding] 903814008994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814008995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814008996 ATP binding site [chemical binding]; other site 903814008997 Mg2+ binding site [ion binding]; other site 903814008998 G-X-G motif; other site 903814008999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814009000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814009001 Walker A/P-loop; other site 903814009002 ATP binding site [chemical binding]; other site 903814009003 Q-loop/lid; other site 903814009004 ABC transporter signature motif; other site 903814009005 Walker B; other site 903814009006 D-loop; other site 903814009007 H-loop/switch region; other site 903814009008 FtsX-like permease family; Region: FtsX; pfam02687 903814009009 FtsX-like permease family; Region: FtsX; pfam02687 903814009010 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 903814009011 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 903814009012 substrate binding pocket [chemical binding]; other site 903814009013 chain length determination region; other site 903814009014 substrate-Mg2+ binding site; other site 903814009015 catalytic residues [active] 903814009016 aspartate-rich region 1; other site 903814009017 active site lid residues [active] 903814009018 aspartate-rich region 2; other site 903814009019 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 903814009020 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 903814009021 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 903814009022 generic binding surface I; other site 903814009023 generic binding surface II; other site 903814009024 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 903814009025 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 903814009026 putative RNA binding site [nucleotide binding]; other site 903814009027 Asp23 family; Region: Asp23; pfam03780 903814009028 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 903814009029 elongation factor P; Validated; Region: PRK00529 903814009030 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 903814009031 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 903814009032 RNA binding site [nucleotide binding]; other site 903814009033 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 903814009034 RNA binding site [nucleotide binding]; other site 903814009035 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 903814009036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814009037 S-adenosylmethionine binding site [chemical binding]; other site 903814009038 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 903814009039 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 903814009040 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 903814009041 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 903814009042 RNA binding site [nucleotide binding]; other site 903814009043 transcription termination factor Rho; Provisional; Region: rho; PRK09376 903814009044 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 903814009045 RNA binding site [nucleotide binding]; other site 903814009046 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 903814009047 Walker A motif; other site 903814009048 ATP binding site [chemical binding]; other site 903814009049 Walker B motif; other site 903814009050 GTP-binding protein LepA; Provisional; Region: PRK05433 903814009051 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 903814009052 G1 box; other site 903814009053 putative GEF interaction site [polypeptide binding]; other site 903814009054 GTP/Mg2+ binding site [chemical binding]; other site 903814009055 Switch I region; other site 903814009056 G2 box; other site 903814009057 G3 box; other site 903814009058 Switch II region; other site 903814009059 G4 box; other site 903814009060 G5 box; other site 903814009061 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 903814009062 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 903814009063 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 903814009064 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 903814009065 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 903814009066 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 903814009067 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 903814009068 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 903814009069 Competence protein; Region: Competence; pfam03772 903814009070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 903814009071 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 903814009072 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 903814009073 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 903814009074 active site 903814009075 nucleophile elbow; other site 903814009076 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 903814009077 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 903814009078 Glutamine amidotransferases class-II; Region: GATase_4; pfam13230 903814009079 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 903814009080 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 903814009081 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 903814009082 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 903814009083 dimer interface [polypeptide binding]; other site 903814009084 anticodon binding site; other site 903814009085 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 903814009086 homodimer interface [polypeptide binding]; other site 903814009087 motif 1; other site 903814009088 active site 903814009089 motif 2; other site 903814009090 GAD domain; Region: GAD; pfam02938 903814009091 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 903814009092 motif 3; other site 903814009093 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 903814009094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 903814009095 flexible hinge region; other site 903814009096 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 903814009097 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814009098 TfoX C-terminal domain; Region: TfoX_C; pfam04994 903814009099 Nitroreductase family; Region: Nitroreductase; pfam00881 903814009100 FMN binding site [chemical binding]; other site 903814009101 dimer interface [polypeptide binding]; other site 903814009102 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 903814009103 dimer interface [polypeptide binding]; other site 903814009104 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814009105 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814009106 Walker A/P-loop; other site 903814009107 ATP binding site [chemical binding]; other site 903814009108 Q-loop/lid; other site 903814009109 ABC transporter signature motif; other site 903814009110 Walker B; other site 903814009111 D-loop; other site 903814009112 H-loop/switch region; other site 903814009113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814009114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814009115 putative acetyltransferase; Provisional; Region: PRK03624 903814009116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814009117 Coenzyme A binding pocket [chemical binding]; other site 903814009118 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 903814009119 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 903814009120 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 903814009121 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 903814009122 putative active site [active] 903814009123 dimerization interface [polypeptide binding]; other site 903814009124 putative tRNAtyr binding site [nucleotide binding]; other site 903814009125 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 903814009126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814009127 Zn2+ binding site [ion binding]; other site 903814009128 Mg2+ binding site [ion binding]; other site 903814009129 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 903814009130 synthetase active site [active] 903814009131 NTP binding site [chemical binding]; other site 903814009132 metal binding site [ion binding]; metal-binding site 903814009133 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 903814009134 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 903814009135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814009136 active site 903814009137 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 903814009138 DHH family; Region: DHH; pfam01368 903814009139 DHHA1 domain; Region: DHHA1; pfam02272 903814009140 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 903814009141 Protein export membrane protein; Region: SecD_SecF; pfam02355 903814009142 protein-export membrane protein SecD; Region: secD; TIGR01129 903814009143 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 903814009144 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 903814009145 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 903814009146 active site 903814009147 HIGH motif; other site 903814009148 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 903814009149 active site 903814009150 KMSKS motif; other site 903814009151 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 903814009152 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 903814009153 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 903814009154 G1 box; other site 903814009155 GTP/Mg2+ binding site [chemical binding]; other site 903814009156 Switch I region; other site 903814009157 G2 box; other site 903814009158 G3 box; other site 903814009159 Switch II region; other site 903814009160 G4 box; other site 903814009161 G5 box; other site 903814009162 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 903814009163 Found in ATP-dependent protease La (LON); Region: LON; smart00464 903814009164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009165 Walker A motif; other site 903814009166 ATP binding site [chemical binding]; other site 903814009167 Walker B motif; other site 903814009168 arginine finger; other site 903814009169 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 903814009170 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 903814009171 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 903814009172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009173 Walker A motif; other site 903814009174 ATP binding site [chemical binding]; other site 903814009175 Walker B motif; other site 903814009176 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 903814009177 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 903814009178 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 903814009179 oligomer interface [polypeptide binding]; other site 903814009180 active site residues [active] 903814009181 trigger factor; Provisional; Region: tig; PRK01490 903814009182 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 903814009183 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 903814009184 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 903814009185 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 903814009186 Walker A/P-loop; other site 903814009187 ATP binding site [chemical binding]; other site 903814009188 Q-loop/lid; other site 903814009189 ABC transporter signature motif; other site 903814009190 Walker B; other site 903814009191 D-loop; other site 903814009192 H-loop/switch region; other site 903814009193 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 903814009194 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 903814009195 Walker A/P-loop; other site 903814009196 ATP binding site [chemical binding]; other site 903814009197 Q-loop/lid; other site 903814009198 ABC transporter signature motif; other site 903814009199 Walker B; other site 903814009200 D-loop; other site 903814009201 H-loop/switch region; other site 903814009202 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 903814009203 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 903814009204 TM-ABC transporter signature motif; other site 903814009205 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 903814009206 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 903814009207 TM-ABC transporter signature motif; other site 903814009208 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 903814009209 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 903814009210 putative ligand binding site [chemical binding]; other site 903814009211 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 903814009212 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 903814009213 minor groove reading motif; other site 903814009214 helix-hairpin-helix signature motif; other site 903814009215 substrate binding pocket [chemical binding]; other site 903814009216 active site 903814009217 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 903814009218 Cupin domain; Region: Cupin_2; pfam07883 903814009219 Transglycosylase; Region: Transgly; pfam00912 903814009220 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 903814009221 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 903814009222 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 903814009223 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 903814009224 active site 903814009225 hypothetical protein; Reviewed; Region: PRK00024 903814009226 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 903814009227 MPN+ (JAMM) motif; other site 903814009228 Zinc-binding site [ion binding]; other site 903814009229 Transcriptional regulators [Transcription]; Region: MarR; COG1846 903814009230 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 903814009231 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 903814009232 Predicted membrane protein [Function unknown]; Region: COG1511 903814009233 Predicted membrane protein [Function unknown]; Region: COG1511 903814009234 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 903814009235 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 903814009236 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 903814009237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814009238 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 903814009239 HSP70 interaction site [polypeptide binding]; other site 903814009240 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 903814009241 substrate binding site [polypeptide binding]; other site 903814009242 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 903814009243 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 903814009244 Zn binding sites [ion binding]; other site 903814009245 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 903814009246 dimer interface [polypeptide binding]; other site 903814009247 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 903814009248 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 903814009249 nucleotide binding site [chemical binding]; other site 903814009250 NEF interaction site [polypeptide binding]; other site 903814009251 SBD interface [polypeptide binding]; other site 903814009252 GrpE; Region: GrpE; pfam01025 903814009253 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 903814009254 dimer interface [polypeptide binding]; other site 903814009255 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 903814009256 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 903814009257 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 903814009258 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 903814009259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814009260 FeS/SAM binding site; other site 903814009261 HemN C-terminal domain; Region: HemN_C; pfam06969 903814009262 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 903814009263 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 903814009264 Predicted transcriptional regulator [Transcription]; Region: COG2378 903814009265 HTH domain; Region: HTH_11; pfam08279 903814009266 WYL domain; Region: WYL; pfam13280 903814009267 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814009268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814009269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 903814009270 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 903814009271 BRO family, N-terminal domain; Region: Bro-N; cl10591 903814009272 Accessory gene regulator B; Region: AgrB; pfam04647 903814009273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 903814009274 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 903814009275 HlyD family secretion protein; Region: HlyD_3; pfam13437 903814009276 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 903814009277 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 903814009278 putative active site [active] 903814009279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814009280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814009281 Walker A/P-loop; other site 903814009282 ATP binding site [chemical binding]; other site 903814009283 Q-loop/lid; other site 903814009284 ABC transporter signature motif; other site 903814009285 Walker B; other site 903814009286 D-loop; other site 903814009287 H-loop/switch region; other site 903814009288 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 903814009289 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 903814009290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814009291 ATP binding site [chemical binding]; other site 903814009292 Mg2+ binding site [ion binding]; other site 903814009293 G-X-G motif; other site 903814009294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814009295 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814009296 active site 903814009297 phosphorylation site [posttranslational modification] 903814009298 intermolecular recognition site; other site 903814009299 dimerization interface [polypeptide binding]; other site 903814009300 LytTr DNA-binding domain; Region: LytTR; smart00850 903814009301 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 903814009302 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 903814009303 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 903814009304 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 903814009305 Alcohol acetyltransferase; Region: AATase; pfam07247 903814009306 prolyl-tRNA synthetase; Provisional; Region: PRK08661 903814009307 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 903814009308 dimer interface [polypeptide binding]; other site 903814009309 motif 1; other site 903814009310 active site 903814009311 motif 2; other site 903814009312 motif 3; other site 903814009313 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 903814009314 anticodon binding site; other site 903814009315 zinc-binding site [ion binding]; other site 903814009316 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 903814009317 core dimer interface [polypeptide binding]; other site 903814009318 peripheral dimer interface [polypeptide binding]; other site 903814009319 L10 interface [polypeptide binding]; other site 903814009320 L11 interface [polypeptide binding]; other site 903814009321 putative EF-Tu interaction site [polypeptide binding]; other site 903814009322 putative EF-G interaction site [polypeptide binding]; other site 903814009323 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 903814009324 23S rRNA interface [nucleotide binding]; other site 903814009325 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 903814009326 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 903814009327 mRNA/rRNA interface [nucleotide binding]; other site 903814009328 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 903814009329 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 903814009330 23S rRNA interface [nucleotide binding]; other site 903814009331 L7/L12 interface [polypeptide binding]; other site 903814009332 putative thiostrepton binding site; other site 903814009333 L25 interface [polypeptide binding]; other site 903814009334 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 903814009335 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 903814009336 putative homodimer interface [polypeptide binding]; other site 903814009337 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 903814009338 heterodimer interface [polypeptide binding]; other site 903814009339 homodimer interface [polypeptide binding]; other site 903814009340 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 903814009341 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 903814009342 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 903814009343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814009344 Coenzyme A binding pocket [chemical binding]; other site 903814009345 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 903814009346 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 903814009347 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 903814009348 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 903814009349 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 903814009350 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 903814009351 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 903814009352 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814009353 ACS interaction site; other site 903814009354 CODH interaction site; other site 903814009355 metal cluster binding site [ion binding]; other site 903814009356 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 903814009357 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 903814009358 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 903814009359 P-loop; other site 903814009360 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814009361 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 903814009362 ACS interaction site; other site 903814009363 CODH interaction site; other site 903814009364 metal cluster binding site [ion binding]; other site 903814009365 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 903814009366 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814009367 substrate binding pocket [chemical binding]; other site 903814009368 dimer interface [polypeptide binding]; other site 903814009369 inhibitor binding site; inhibition site 903814009370 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 903814009371 Putative Fe-S cluster; Region: FeS; pfam04060 903814009372 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 903814009373 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 903814009374 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 903814009375 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 903814009376 catalytic loop [active] 903814009377 iron binding site [ion binding]; other site 903814009378 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 903814009379 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 903814009380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814009381 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 903814009382 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 903814009383 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 903814009384 putative active site [active] 903814009385 catalytic site [active] 903814009386 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 903814009387 putative active site [active] 903814009388 catalytic site [active] 903814009389 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 903814009390 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 903814009391 NADP binding site [chemical binding]; other site 903814009392 active site 903814009393 putative substrate binding site [chemical binding]; other site 903814009394 peptidase T; Region: peptidase-T; TIGR01882 903814009395 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 903814009396 metal binding site [ion binding]; metal-binding site 903814009397 dimer interface [polypeptide binding]; other site 903814009398 peptide chain release factor 1; Validated; Region: prfA; PRK00591 903814009399 This domain is found in peptide chain release factors; Region: PCRF; smart00937 903814009400 RF-1 domain; Region: RF-1; pfam00472 903814009401 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814009402 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814009403 putative hydrolase; Validated; Region: PRK09248 903814009404 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 903814009405 active site 903814009406 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 903814009407 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 903814009408 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 903814009409 Hpr binding site; other site 903814009410 active site 903814009411 homohexamer subunit interaction site [polypeptide binding]; other site 903814009412 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 903814009413 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 903814009414 GIY-YIG motif/motif A; other site 903814009415 active site 903814009416 catalytic site [active] 903814009417 putative DNA binding site [nucleotide binding]; other site 903814009418 metal binding site [ion binding]; metal-binding site 903814009419 UvrB/uvrC motif; Region: UVR; pfam02151 903814009420 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 903814009421 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 903814009422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814009423 motif II; other site 903814009424 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 903814009425 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 903814009426 active site 903814009427 intersubunit interactions; other site 903814009428 catalytic residue [active] 903814009429 4-alpha-glucanotransferase; Provisional; Region: PRK14508 903814009430 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 903814009431 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 903814009432 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 903814009433 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 903814009434 Interdomain contacts; other site 903814009435 Cytokine receptor motif; other site 903814009436 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 903814009437 ATP cone domain; Region: ATP-cone; pfam03477 903814009438 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 903814009439 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 903814009440 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 903814009441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814009442 FeS/SAM binding site; other site 903814009443 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 903814009444 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 903814009445 dimer interface [polypeptide binding]; other site 903814009446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814009447 catalytic residue [active] 903814009448 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 903814009449 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 903814009450 homodimer interface [polypeptide binding]; other site 903814009451 substrate-cofactor binding pocket; other site 903814009452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814009453 catalytic residue [active] 903814009454 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 903814009455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814009456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814009457 homodimer interface [polypeptide binding]; other site 903814009458 catalytic residue [active] 903814009459 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 903814009460 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 903814009461 CBS domain; Region: CBS; pfam00571 903814009462 DHH family; Region: DHH; pfam01368 903814009463 DHHA2 domain; Region: DHHA2; pfam02833 903814009464 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 903814009465 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 903814009466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814009467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814009468 non-specific DNA binding site [nucleotide binding]; other site 903814009469 salt bridge; other site 903814009470 sequence-specific DNA binding site [nucleotide binding]; other site 903814009471 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 903814009472 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 903814009473 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814009474 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 903814009475 substrate binding pocket [chemical binding]; other site 903814009476 dimer interface [polypeptide binding]; other site 903814009477 inhibitor binding site; inhibition site 903814009478 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814009479 B12 binding site [chemical binding]; other site 903814009480 hypothetical protein; Provisional; Region: PRK04334 903814009481 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 903814009482 4Fe-4S binding domain; Region: Fer4; cl02805 903814009483 Domain of unknown function DUF39; Region: DUF39; pfam01837 903814009484 peptide chain release factor 2; Provisional; Region: PRK05589 903814009485 PCRF domain; Region: PCRF; pfam03462 903814009486 RF-1 domain; Region: RF-1; pfam00472 903814009487 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 903814009488 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 903814009489 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 903814009490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814009491 nucleotide binding region [chemical binding]; other site 903814009492 ATP-binding site [chemical binding]; other site 903814009493 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 903814009494 30S subunit binding site; other site 903814009495 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 903814009496 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 903814009497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814009498 FeS/SAM binding site; other site 903814009499 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 903814009500 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 903814009501 Preprotein translocase subunit; Region: YajC; pfam02699 903814009502 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 903814009503 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 903814009504 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 903814009505 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 903814009506 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 903814009507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009508 Walker A motif; other site 903814009509 ATP binding site [chemical binding]; other site 903814009510 Walker B motif; other site 903814009511 arginine finger; other site 903814009512 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 903814009513 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 903814009514 RuvA N terminal domain; Region: RuvA_N; pfam01330 903814009515 DNA repair protein RadA; Provisional; Region: PRK11823 903814009516 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 903814009517 Walker A motif/ATP binding site; other site 903814009518 ATP binding site [chemical binding]; other site 903814009519 Walker B motif; other site 903814009520 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 903814009521 VanZ like family; Region: VanZ; pfam04892 903814009522 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 903814009523 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 903814009524 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 903814009525 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 903814009526 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 903814009527 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 903814009528 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 903814009529 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 903814009530 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814009531 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 903814009532 G4 box; other site 903814009533 G5 box; other site 903814009534 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 903814009535 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 903814009536 putative deacylase active site [active] 903814009537 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814009538 EamA-like transporter family; Region: EamA; pfam00892 903814009539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814009540 PAS domain; Region: PAS_9; pfam13426 903814009541 putative active site [active] 903814009542 heme pocket [chemical binding]; other site 903814009543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009544 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 903814009545 Walker A motif; other site 903814009546 ATP binding site [chemical binding]; other site 903814009547 Walker B motif; other site 903814009548 arginine finger; other site 903814009549 BCCT family transporter; Region: BCCT; pfam02028 903814009550 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814009551 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 903814009552 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 903814009553 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814009554 B12 binding site [chemical binding]; other site 903814009555 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814009556 Sensory domain found in PocR; Region: PocR; pfam10114 903814009557 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 903814009558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814009559 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814009560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814009561 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 903814009562 metal ion-dependent adhesion site (MIDAS); other site 903814009563 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 903814009564 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814009565 EamA-like transporter family; Region: EamA; pfam00892 903814009566 EamA-like transporter family; Region: EamA; pfam00892 903814009567 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814009568 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814009569 B12 binding site [chemical binding]; other site 903814009570 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 903814009571 oligomerization interface [polypeptide binding]; other site 903814009572 active site 903814009573 metal binding site [ion binding]; metal-binding site 903814009574 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 903814009575 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 903814009576 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814009577 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814009578 BCCT family transporter; Region: BCCT; pfam02028 903814009579 PAS domain; Region: PAS_9; pfam13426 903814009580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814009581 putative active site [active] 903814009582 heme pocket [chemical binding]; other site 903814009583 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814009584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009585 Walker A motif; other site 903814009586 ATP binding site [chemical binding]; other site 903814009587 Walker B motif; other site 903814009588 arginine finger; other site 903814009589 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 903814009590 BCCT family transporter; Region: BCCT; pfam02028 903814009591 hypothetical protein; Provisional; Region: PRK07475 903814009592 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814009593 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814009594 PAS domain; Region: PAS_9; pfam13426 903814009595 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 903814009596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009597 Walker A motif; other site 903814009598 ATP binding site [chemical binding]; other site 903814009599 Walker B motif; other site 903814009600 arginine finger; other site 903814009601 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 903814009602 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 903814009603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 903814009604 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 903814009605 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 903814009606 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 903814009607 Sel1-like repeats; Region: SEL1; smart00671 903814009608 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 903814009609 putative active site [active] 903814009610 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 903814009611 synthetase active site [active] 903814009612 NTP binding site [chemical binding]; other site 903814009613 metal binding site [ion binding]; metal-binding site 903814009614 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 903814009615 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 903814009616 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 903814009617 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 903814009618 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 903814009619 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814009620 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814009621 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 903814009622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814009623 putative active site [active] 903814009624 heme pocket [chemical binding]; other site 903814009625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814009626 putative active site [active] 903814009627 heme pocket [chemical binding]; other site 903814009628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814009629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814009630 dimer interface [polypeptide binding]; other site 903814009631 phosphorylation site [posttranslational modification] 903814009632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814009633 ATP binding site [chemical binding]; other site 903814009634 Mg2+ binding site [ion binding]; other site 903814009635 G-X-G motif; other site 903814009636 Response regulator receiver domain; Region: Response_reg; pfam00072 903814009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814009638 active site 903814009639 phosphorylation site [posttranslational modification] 903814009640 intermolecular recognition site; other site 903814009641 dimerization interface [polypeptide binding]; other site 903814009642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814009643 Response regulator receiver domain; Region: Response_reg; pfam00072 903814009644 active site 903814009645 phosphorylation site [posttranslational modification] 903814009646 intermolecular recognition site; other site 903814009647 dimerization interface [polypeptide binding]; other site 903814009648 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 903814009649 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814009650 EamA-like transporter family; Region: EamA; pfam00892 903814009651 EamA-like transporter family; Region: EamA; pfam00892 903814009652 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814009653 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814009654 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814009655 B12 binding site [chemical binding]; other site 903814009656 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 903814009657 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 903814009658 substrate binding pocket [chemical binding]; other site 903814009659 dimer interface [polypeptide binding]; other site 903814009660 inhibitor binding site; inhibition site 903814009661 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 903814009662 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814009663 B12 binding site [chemical binding]; other site 903814009664 cobalt ligand [ion binding]; other site 903814009665 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 903814009666 Sensory domain found in PocR; Region: PocR; pfam10114 903814009667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814009668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814009669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814009670 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814009671 EamA-like transporter family; Region: EamA; pfam00892 903814009672 EamA-like transporter family; Region: EamA; pfam00892 903814009673 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814009674 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814009675 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814009676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814009677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814009678 DNA binding residues [nucleotide binding] 903814009679 ThiC family; Region: ThiC; cl08031 903814009680 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 903814009681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814009682 Zn2+ binding site [ion binding]; other site 903814009683 Mg2+ binding site [ion binding]; other site 903814009684 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814009685 active site 903814009686 DNA binding site [nucleotide binding] 903814009687 Int/Topo IB signature motif; other site 903814009688 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 903814009689 Peptidase family U32; Region: Peptidase_U32; pfam01136 903814009690 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 903814009691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814009692 S-adenosylmethionine binding site [chemical binding]; other site 903814009693 YceG-like family; Region: YceG; pfam02618 903814009694 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 903814009695 dimerization interface [polypeptide binding]; other site 903814009696 Protein of unknown function (DUF964); Region: DUF964; pfam06133 903814009697 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 903814009698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 903814009699 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 903814009700 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 903814009701 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 903814009702 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 903814009703 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 903814009704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 903814009705 active site 903814009706 catalytic tetrad [active] 903814009707 hypothetical protein; Provisional; Region: PRK05473 903814009708 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 903814009709 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 903814009710 motif 1; other site 903814009711 active site 903814009712 motif 2; other site 903814009713 motif 3; other site 903814009714 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 903814009715 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 903814009716 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 903814009717 Domain of unknown function DUF20; Region: UPF0118; pfam01594 903814009718 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 903814009719 Domain of unknown function DUF20; Region: UPF0118; pfam01594 903814009720 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 903814009721 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 903814009722 trimerization site [polypeptide binding]; other site 903814009723 active site 903814009724 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 903814009725 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 903814009726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814009727 catalytic residue [active] 903814009728 Transcriptional regulator; Region: Rrf2; cl17282 903814009729 Rrf2 family protein; Region: rrf2_super; TIGR00738 903814009730 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814009731 FtsX-like permease family; Region: FtsX; pfam02687 903814009732 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814009733 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 903814009734 FtsX-like permease family; Region: FtsX; pfam02687 903814009735 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814009736 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814009737 Walker A/P-loop; other site 903814009738 ATP binding site [chemical binding]; other site 903814009739 Q-loop/lid; other site 903814009740 ABC transporter signature motif; other site 903814009741 Walker B; other site 903814009742 D-loop; other site 903814009743 H-loop/switch region; other site 903814009744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814009745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814009746 dimer interface [polypeptide binding]; other site 903814009747 phosphorylation site [posttranslational modification] 903814009748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814009749 ATP binding site [chemical binding]; other site 903814009750 Mg2+ binding site [ion binding]; other site 903814009751 G-X-G motif; other site 903814009752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814009753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814009754 active site 903814009755 phosphorylation site [posttranslational modification] 903814009756 intermolecular recognition site; other site 903814009757 dimerization interface [polypeptide binding]; other site 903814009758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814009759 DNA binding site [nucleotide binding] 903814009760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814009761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814009762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 903814009763 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 903814009764 active site 903814009765 catalytic residues [active] 903814009766 metal binding site [ion binding]; metal-binding site 903814009767 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 903814009768 putative binding surface; other site 903814009769 active site 903814009770 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 903814009771 catalytic residues [active] 903814009772 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 903814009773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814009774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 903814009775 Transcriptional regulator; Region: Rrf2; pfam02082 903814009776 Rrf2 family protein; Region: rrf2_super; TIGR00738 903814009777 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 903814009778 active site residue [active] 903814009779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814009780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814009781 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814009782 FtsX-like permease family; Region: FtsX; pfam02687 903814009783 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814009784 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814009785 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814009786 FtsX-like permease family; Region: FtsX; pfam02687 903814009787 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814009788 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814009789 Walker A/P-loop; other site 903814009790 ATP binding site [chemical binding]; other site 903814009791 Q-loop/lid; other site 903814009792 ABC transporter signature motif; other site 903814009793 Walker B; other site 903814009794 D-loop; other site 903814009795 H-loop/switch region; other site 903814009796 Nuclease-related domain; Region: NERD; pfam08378 903814009797 HRDC domain; Region: HRDC; cl02578 903814009798 Nuclease-related domain; Region: NERD; pfam08378 903814009799 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 903814009800 Na2 binding site [ion binding]; other site 903814009801 putative substrate binding site 1 [chemical binding]; other site 903814009802 Na binding site 1 [ion binding]; other site 903814009803 putative substrate binding site 2 [chemical binding]; other site 903814009804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814009805 MarR family; Region: MarR; pfam01047 903814009806 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 903814009807 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 903814009808 FAD binding site [chemical binding]; other site 903814009809 homotetramer interface [polypeptide binding]; other site 903814009810 substrate binding pocket [chemical binding]; other site 903814009811 catalytic base [active] 903814009812 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 903814009813 Coenzyme A transferase; Region: CoA_trans; smart00882 903814009814 Coenzyme A transferase; Region: CoA_trans; cl17247 903814009815 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 903814009816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 903814009817 substrate binding site [chemical binding]; other site 903814009818 oxyanion hole (OAH) forming residues; other site 903814009819 trimer interface [polypeptide binding]; other site 903814009820 Integral membrane protein DUF95; Region: DUF95; pfam01944 903814009821 UPF0489 domain; Region: UPF0489; pfam12640 903814009822 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 903814009823 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 903814009824 FMN binding site [chemical binding]; other site 903814009825 active site 903814009826 catalytic residues [active] 903814009827 substrate binding site [chemical binding]; other site 903814009828 pantothenate kinase; Reviewed; Region: PRK13318 903814009829 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 903814009830 active site 1 [active] 903814009831 active site 2 [active] 903814009832 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 903814009833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814009834 Walker A motif; other site 903814009835 ATP binding site [chemical binding]; other site 903814009836 Walker B motif; other site 903814009837 arginine finger; other site 903814009838 Peptidase family M41; Region: Peptidase_M41; pfam01434 903814009839 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814009840 active site 903814009841 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 903814009842 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 903814009843 Ligand Binding Site [chemical binding]; other site 903814009844 TilS substrate C-terminal domain; Region: TilS_C; smart00977 903814009845 exopolyphosphatase; Region: exo_poly_only; TIGR03706 903814009846 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 903814009847 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 903814009848 Septum formation initiator; Region: DivIC; pfam04977 903814009849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814009850 RNA binding surface [nucleotide binding]; other site 903814009851 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 903814009852 IHF - DNA interface [nucleotide binding]; other site 903814009853 IHF dimer interface [polypeptide binding]; other site 903814009854 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 903814009855 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 903814009856 active site 903814009857 homodimer interface [polypeptide binding]; other site 903814009858 SAM binding site [chemical binding]; other site 903814009859 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 903814009860 homodimer interface [polypeptide binding]; other site 903814009861 metal binding site [ion binding]; metal-binding site 903814009862 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 903814009863 homodimer interface [polypeptide binding]; other site 903814009864 active site 903814009865 putative chemical substrate binding site [chemical binding]; other site 903814009866 metal binding site [ion binding]; metal-binding site 903814009867 stage V sporulation protein B; Region: spore_V_B; TIGR02900 903814009868 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 903814009869 SurA N-terminal domain; Region: SurA_N_3; cl07813 903814009870 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 903814009871 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 903814009872 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 903814009873 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 903814009874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814009875 ATP binding site [chemical binding]; other site 903814009876 putative Mg++ binding site [ion binding]; other site 903814009877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814009878 nucleotide binding region [chemical binding]; other site 903814009879 ATP-binding site [chemical binding]; other site 903814009880 TRCF domain; Region: TRCF; pfam03461 903814009881 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 903814009882 putative active site [active] 903814009883 catalytic residue [active] 903814009884 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 903814009885 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 903814009886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814009887 active site 903814009888 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 903814009889 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 903814009890 Substrate binding site; other site 903814009891 Mg++ binding site; other site 903814009892 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 903814009893 active site 903814009894 substrate binding site [chemical binding]; other site 903814009895 CoA binding site [chemical binding]; other site 903814009896 regulatory protein SpoVG; Reviewed; Region: PRK13259 903814009897 pur operon repressor; Provisional; Region: PRK09213 903814009898 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 903814009899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 903814009900 active site 903814009901 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 903814009902 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 903814009903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 903814009904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 903814009905 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 903814009906 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 903814009907 active site 903814009908 nucleophile elbow; other site 903814009909 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 903814009910 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 903814009911 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 903814009912 nudix motif; other site 903814009913 Rubrerythrin [Energy production and conversion]; Region: COG1592 903814009914 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 903814009915 binuclear metal center [ion binding]; other site 903814009916 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 903814009917 iron binding site [ion binding]; other site 903814009918 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 903814009919 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 903814009920 nudix motif; other site 903814009921 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 903814009922 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 903814009923 non-heme iron binding site [ion binding]; other site 903814009924 dimer interface [polypeptide binding]; other site 903814009925 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 903814009926 non-heme iron binding site [ion binding]; other site 903814009927 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 903814009928 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 903814009929 putative acyl-acceptor binding pocket; other site 903814009930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814009931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814009932 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814009933 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 903814009934 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 903814009935 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 903814009936 ATP binding site [chemical binding]; other site 903814009937 Mg++ binding site [ion binding]; other site 903814009938 motif III; other site 903814009939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814009940 nucleotide binding region [chemical binding]; other site 903814009941 ATP-binding site [chemical binding]; other site 903814009942 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 903814009943 RNA binding site [nucleotide binding]; other site 903814009944 Protein of unknown function, DUF488; Region: DUF488; cl01246 903814009945 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 903814009946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814009947 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 903814009948 putative active site pocket [active] 903814009949 cleavage site 903814009950 Predicted membrane protein [Function unknown]; Region: COG4684 903814009951 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 903814009952 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 903814009953 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 903814009954 DXD motif; other site 903814009955 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 903814009956 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 903814009957 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 903814009958 Walker A/P-loop; other site 903814009959 ATP binding site [chemical binding]; other site 903814009960 Q-loop/lid; other site 903814009961 ABC transporter signature motif; other site 903814009962 Walker B; other site 903814009963 D-loop; other site 903814009964 H-loop/switch region; other site 903814009965 Transcriptional regulator [Transcription]; Region: LytR; COG1316 903814009966 Predicted membrane protein [Function unknown]; Region: COG2246 903814009967 GtrA-like protein; Region: GtrA; pfam04138 903814009968 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 903814009969 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 903814009970 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814009971 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 903814009972 NAD binding site [chemical binding]; other site 903814009973 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814009974 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 903814009975 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 903814009976 Probable Catalytic site; other site 903814009977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 903814009978 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 903814009979 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 903814009980 Probable Catalytic site; other site 903814009981 metal-binding site 903814009982 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 903814009983 Rhamnan synthesis protein F; Region: RgpF; pfam05045 903814009984 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 903814009985 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 903814009986 active site 903814009987 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 903814009988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814009989 NAD(P) binding site [chemical binding]; other site 903814009990 active site 903814009991 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814009992 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 903814009993 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 903814009994 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 903814009995 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 903814009996 active site 903814009997 metal binding site [ion binding]; metal-binding site 903814009998 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 903814009999 Predicted membrane protein [Function unknown]; Region: COG2246 903814010000 GtrA-like protein; Region: GtrA; pfam04138 903814010001 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 903814010002 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 903814010003 Ligand binding site; other site 903814010004 Putative Catalytic site; other site 903814010005 DXD motif; other site 903814010006 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 903814010007 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 903814010008 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 903814010009 Walker A/P-loop; other site 903814010010 ATP binding site [chemical binding]; other site 903814010011 Q-loop/lid; other site 903814010012 ABC transporter signature motif; other site 903814010013 Walker B; other site 903814010014 D-loop; other site 903814010015 H-loop/switch region; other site 903814010016 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 903814010017 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 903814010018 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 903814010019 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 903814010020 NAD binding site [chemical binding]; other site 903814010021 substrate binding site [chemical binding]; other site 903814010022 homodimer interface [polypeptide binding]; other site 903814010023 active site 903814010024 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 903814010025 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 903814010026 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 903814010027 substrate binding site; other site 903814010028 tetramer interface; other site 903814010029 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 903814010030 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 903814010031 NADP binding site [chemical binding]; other site 903814010032 active site 903814010033 putative substrate binding site [chemical binding]; other site 903814010034 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 903814010035 aconitate hydratase; Validated; Region: PRK07229 903814010036 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 903814010037 substrate binding site [chemical binding]; other site 903814010038 ligand binding site [chemical binding]; other site 903814010039 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 903814010040 substrate binding site [chemical binding]; other site 903814010041 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 903814010042 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 903814010043 glycogen branching enzyme; Provisional; Region: PRK12313 903814010044 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 903814010045 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 903814010046 active site 903814010047 catalytic site [active] 903814010048 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 903814010049 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 903814010050 homodimer interface [polypeptide binding]; other site 903814010051 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 903814010052 active site pocket [active] 903814010053 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814010054 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 903814010055 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 903814010056 ligand binding site; other site 903814010057 oligomer interface; other site 903814010058 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 903814010059 dimer interface [polypeptide binding]; other site 903814010060 N-terminal domain interface [polypeptide binding]; other site 903814010061 sulfate 1 binding site; other site 903814010062 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 903814010063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 903814010064 active site 903814010065 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 903814010066 dimer interface [polypeptide binding]; other site 903814010067 N-terminal domain interface [polypeptide binding]; other site 903814010068 sulfate 1 binding site; other site 903814010069 glycogen synthase; Provisional; Region: glgA; PRK00654 903814010070 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 903814010071 ADP-binding pocket [chemical binding]; other site 903814010072 homodimer interface [polypeptide binding]; other site 903814010073 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 903814010074 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 903814010075 active site 903814010076 homodimer interface [polypeptide binding]; other site 903814010077 catalytic site [active] 903814010078 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 903814010079 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 903814010080 dimer interface [polypeptide binding]; other site 903814010081 putative anticodon binding site; other site 903814010082 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 903814010083 motif 1; other site 903814010084 active site 903814010085 motif 2; other site 903814010086 motif 3; other site 903814010087 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 903814010088 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 903814010089 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 903814010090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 903814010091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 903814010092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 903814010093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 903814010094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 903814010095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 903814010096 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 903814010097 IMP binding site; other site 903814010098 dimer interface [polypeptide binding]; other site 903814010099 interdomain contacts; other site 903814010100 partial ornithine binding site; other site 903814010101 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 903814010102 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 903814010103 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 903814010104 catalytic site [active] 903814010105 subunit interface [polypeptide binding]; other site 903814010106 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 903814010107 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 903814010108 GDP-binding site [chemical binding]; other site 903814010109 ACT binding site; other site 903814010110 IMP binding site; other site 903814010111 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814010112 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814010113 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814010114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814010115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814010116 DNA binding residues [nucleotide binding] 903814010117 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 903814010118 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 903814010119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814010120 ATP binding site [chemical binding]; other site 903814010121 putative Mg++ binding site [ion binding]; other site 903814010122 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 903814010123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814010124 nucleotide binding region [chemical binding]; other site 903814010125 ATP-binding site [chemical binding]; other site 903814010126 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010127 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010128 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010129 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 903814010130 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 903814010131 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 903814010132 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 903814010133 Walker A/P-loop; other site 903814010134 ATP binding site [chemical binding]; other site 903814010135 Q-loop/lid; other site 903814010136 ABC transporter signature motif; other site 903814010137 Walker B; other site 903814010138 D-loop; other site 903814010139 H-loop/switch region; other site 903814010140 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 903814010141 Walker A/P-loop; other site 903814010142 ATP binding site [chemical binding]; other site 903814010143 Q-loop/lid; other site 903814010144 ABC transporter signature motif; other site 903814010145 Walker B; other site 903814010146 D-loop; other site 903814010147 H-loop/switch region; other site 903814010148 Leucine rich repeat; Region: LRR_8; pfam13855 903814010149 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010150 Leucine rich repeat; Region: LRR_8; pfam13855 903814010151 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010152 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010153 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 903814010154 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 903814010155 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814010156 Bacterial Ig-like domain 2; Region: BID_2; smart00635 903814010157 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 903814010158 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 903814010159 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 903814010160 active site 903814010161 PQQ-like domain; Region: PQQ_2; pfam13360 903814010162 Trp docking motif [polypeptide binding]; other site 903814010163 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 903814010164 dockerin binding interface; other site 903814010165 MAEBL; Provisional; Region: PTZ00121 903814010166 Fusaric acid resistance protein family; Region: FUSC; pfam04632 903814010167 CpXC protein; Region: CpXC; pfam14353 903814010168 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 903814010169 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010170 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010171 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 903814010172 cobalt transport protein CbiM; Validated; Region: PRK08319 903814010173 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 903814010174 cobalt transport protein CbiN; Provisional; Region: PRK02898 903814010175 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 903814010176 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 903814010177 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 903814010178 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 903814010179 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 903814010180 peptidase; Reviewed; Region: PRK13004 903814010181 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 903814010182 metal binding site [ion binding]; metal-binding site 903814010183 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814010184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814010185 DNA-binding site [nucleotide binding]; DNA binding site 903814010186 UTRA domain; Region: UTRA; pfam07702 903814010187 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 903814010188 active site 903814010189 NAD binding site [chemical binding]; other site 903814010190 metal binding site [ion binding]; metal-binding site 903814010191 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 903814010192 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 903814010193 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 903814010194 N- and C-terminal domain interface [polypeptide binding]; other site 903814010195 putative active site [active] 903814010196 MgATP binding site [chemical binding]; other site 903814010197 catalytic site [active] 903814010198 metal binding site [ion binding]; metal-binding site 903814010199 putative xylulose binding site [chemical binding]; other site 903814010200 putative homodimer interface [polypeptide binding]; other site 903814010201 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814010202 intersubunit interface [polypeptide binding]; other site 903814010203 active site 903814010204 catalytic residue [active] 903814010205 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814010206 intersubunit interface [polypeptide binding]; other site 903814010207 active site 903814010208 catalytic residue [active] 903814010209 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 903814010210 intersubunit interface [polypeptide binding]; other site 903814010211 active site 903814010212 catalytic residue [active] 903814010213 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 903814010214 catalytic residue [active] 903814010215 phosphoglycolate phosphatase; Provisional; Region: PRK13222 903814010216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814010217 motif II; other site 903814010218 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 903814010219 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 903814010220 active site 903814010221 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 903814010222 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814010223 intersubunit interface [polypeptide binding]; other site 903814010224 active site 903814010225 zinc binding site [ion binding]; other site 903814010226 Na+ binding site [ion binding]; other site 903814010227 Class I aldolases; Region: Aldolase_Class_I; cl17187 903814010228 catalytic residue [active] 903814010229 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 903814010230 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 903814010231 PYR/PP interface [polypeptide binding]; other site 903814010232 dimer interface [polypeptide binding]; other site 903814010233 TPP binding site [chemical binding]; other site 903814010234 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 903814010235 transketolase; Reviewed; Region: PRK05899 903814010236 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 903814010237 TPP-binding site [chemical binding]; other site 903814010238 dimer interface [polypeptide binding]; other site 903814010239 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 903814010240 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 903814010241 RNA binding site [nucleotide binding]; other site 903814010242 ribosome small subunit-dependent GTPase A; Region: TIGR00157 903814010243 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 903814010244 GTP/Mg2+ binding site [chemical binding]; other site 903814010245 G4 box; other site 903814010246 G5 box; other site 903814010247 G1 box; other site 903814010248 Switch I region; other site 903814010249 G2 box; other site 903814010250 G3 box; other site 903814010251 Switch II region; other site 903814010252 RNHCP domain; Region: RNHCP; pfam12647 903814010253 Mor transcription activator family; Region: Mor; cl02360 903814010254 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814010255 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 903814010256 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 903814010257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814010258 ABC-ATPase subunit interface; other site 903814010259 dimer interface [polypeptide binding]; other site 903814010260 putative PBP binding regions; other site 903814010261 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814010262 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 903814010263 putative ligand binding residues [chemical binding]; other site 903814010264 Methyltransferase domain; Region: Methyltransf_31; pfam13847 903814010265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814010266 S-adenosylmethionine binding site [chemical binding]; other site 903814010267 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 903814010268 Flavoprotein; Region: Flavoprotein; pfam02441 903814010269 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 903814010270 Predicted transcriptional regulators [Transcription]; Region: COG1695 903814010271 Transcriptional regulator PadR-like family; Region: PadR; cl17335 903814010272 K+ potassium transporter; Region: K_trans; pfam02705 903814010273 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 903814010274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814010275 S-adenosylmethionine binding site [chemical binding]; other site 903814010276 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 903814010277 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 903814010278 CrcB-like protein; Region: CRCB; cl09114 903814010279 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 903814010280 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814010281 DNA binding residues [nucleotide binding] 903814010282 drug binding residues [chemical binding]; other site 903814010283 dimer interface [polypeptide binding]; other site 903814010284 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 903814010285 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814010286 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814010287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814010288 Walker A/P-loop; other site 903814010289 ATP binding site [chemical binding]; other site 903814010290 Q-loop/lid; other site 903814010291 ABC transporter signature motif; other site 903814010292 Walker B; other site 903814010293 D-loop; other site 903814010294 H-loop/switch region; other site 903814010295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814010296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814010297 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814010298 Walker A/P-loop; other site 903814010299 ATP binding site [chemical binding]; other site 903814010300 Q-loop/lid; other site 903814010301 ABC transporter signature motif; other site 903814010302 Walker B; other site 903814010303 D-loop; other site 903814010304 H-loop/switch region; other site 903814010305 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 903814010306 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 903814010307 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 903814010308 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 903814010309 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 903814010310 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 903814010311 CHC2 zinc finger; Region: zf-CHC2; cl17510 903814010312 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814010313 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814010314 Walker A/P-loop; other site 903814010315 ATP binding site [chemical binding]; other site 903814010316 Q-loop/lid; other site 903814010317 ABC transporter signature motif; other site 903814010318 Walker B; other site 903814010319 D-loop; other site 903814010320 H-loop/switch region; other site 903814010321 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 903814010322 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814010323 ABC-ATPase subunit interface; other site 903814010324 dimer interface [polypeptide binding]; other site 903814010325 putative PBP binding regions; other site 903814010326 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814010327 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 903814010328 intersubunit interface [polypeptide binding]; other site 903814010329 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 903814010330 classical (c) SDRs; Region: SDR_c; cd05233 903814010331 NAD(P) binding site [chemical binding]; other site 903814010332 active site 903814010333 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814010334 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814010335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814010336 Walker A/P-loop; other site 903814010337 ATP binding site [chemical binding]; other site 903814010338 Q-loop/lid; other site 903814010339 ABC transporter signature motif; other site 903814010340 Walker B; other site 903814010341 D-loop; other site 903814010342 H-loop/switch region; other site 903814010343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814010344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814010345 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 903814010346 putative homodimer interface [polypeptide binding]; other site 903814010347 putative homotetramer interface [polypeptide binding]; other site 903814010348 putative metal binding site [ion binding]; other site 903814010349 putative homodimer-homodimer interface [polypeptide binding]; other site 903814010350 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 903814010351 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 903814010352 2-isopropylmalate synthase; Validated; Region: PRK03739 903814010353 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 903814010354 active site 903814010355 catalytic residues [active] 903814010356 metal binding site [ion binding]; metal-binding site 903814010357 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 903814010358 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814010359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814010360 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 903814010361 putative active site [active] 903814010362 heme pocket [chemical binding]; other site 903814010363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814010364 putative active site [active] 903814010365 heme pocket [chemical binding]; other site 903814010366 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814010367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814010368 metal binding site [ion binding]; metal-binding site 903814010369 active site 903814010370 I-site; other site 903814010371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 903814010372 GAF domain; Region: GAF; cl17456 903814010373 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 903814010374 active site residue [active] 903814010375 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 903814010376 Domain of unknown function DUF20; Region: UPF0118; pfam01594 903814010377 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 903814010378 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 903814010379 G1 box; other site 903814010380 putative GEF interaction site [polypeptide binding]; other site 903814010381 GTP/Mg2+ binding site [chemical binding]; other site 903814010382 Switch I region; other site 903814010383 G2 box; other site 903814010384 G3 box; other site 903814010385 Switch II region; other site 903814010386 G4 box; other site 903814010387 G5 box; other site 903814010388 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 903814010389 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 903814010390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 903814010391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814010392 putative Zn2+ binding site [ion binding]; other site 903814010393 putative DNA binding site [nucleotide binding]; other site 903814010394 Predicted membrane protein [Function unknown]; Region: COG2364 903814010395 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 903814010396 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 903814010397 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 903814010398 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 903814010399 active site 903814010400 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814010401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814010402 non-specific DNA binding site [nucleotide binding]; other site 903814010403 salt bridge; other site 903814010404 sequence-specific DNA binding site [nucleotide binding]; other site 903814010405 Methyltransferase domain; Region: Methyltransf_23; pfam13489 903814010406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814010407 S-adenosylmethionine binding site [chemical binding]; other site 903814010408 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 903814010409 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 903814010410 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 903814010411 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 903814010412 Na+ binding site [ion binding]; other site 903814010413 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 903814010414 N- and C-terminal domain interface [polypeptide binding]; other site 903814010415 D-xylulose kinase; Region: XylB; TIGR01312 903814010416 active site 903814010417 MgATP binding site [chemical binding]; other site 903814010418 catalytic site [active] 903814010419 metal binding site [ion binding]; metal-binding site 903814010420 xylulose binding site [chemical binding]; other site 903814010421 homodimer interface [polypeptide binding]; other site 903814010422 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 903814010423 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 903814010424 23S rRNA interface [nucleotide binding]; other site 903814010425 L3 interface [polypeptide binding]; other site 903814010426 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 903814010427 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 903814010428 dimerization interface 3.5A [polypeptide binding]; other site 903814010429 active site 903814010430 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 903814010431 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 903814010432 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 903814010433 Walker A/P-loop; other site 903814010434 ATP binding site [chemical binding]; other site 903814010435 Q-loop/lid; other site 903814010436 ABC transporter signature motif; other site 903814010437 Walker B; other site 903814010438 D-loop; other site 903814010439 H-loop/switch region; other site 903814010440 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 903814010441 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 903814010442 Walker A/P-loop; other site 903814010443 ATP binding site [chemical binding]; other site 903814010444 Q-loop/lid; other site 903814010445 ABC transporter signature motif; other site 903814010446 Walker B; other site 903814010447 D-loop; other site 903814010448 H-loop/switch region; other site 903814010449 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 903814010450 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 903814010451 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 903814010452 alphaNTD - beta interaction site [polypeptide binding]; other site 903814010453 alphaNTD homodimer interface [polypeptide binding]; other site 903814010454 alphaNTD - beta' interaction site [polypeptide binding]; other site 903814010455 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 903814010456 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 903814010457 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 903814010458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814010459 RNA binding surface [nucleotide binding]; other site 903814010460 30S ribosomal protein S11; Validated; Region: PRK05309 903814010461 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 903814010462 30S ribosomal protein S13; Region: bact_S13; TIGR03631 903814010463 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 903814010464 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 903814010465 rRNA binding site [nucleotide binding]; other site 903814010466 predicted 30S ribosome binding site; other site 903814010467 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 903814010468 RNA binding site [nucleotide binding]; other site 903814010469 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 903814010470 active site 903814010471 adenylate kinase; Reviewed; Region: adk; PRK00279 903814010472 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 903814010473 AMP-binding site [chemical binding]; other site 903814010474 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 903814010475 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 903814010476 SecY translocase; Region: SecY; pfam00344 903814010477 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 903814010478 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 903814010479 23S rRNA binding site [nucleotide binding]; other site 903814010480 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 903814010481 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 903814010482 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 903814010483 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 903814010484 5S rRNA interface [nucleotide binding]; other site 903814010485 23S rRNA interface [nucleotide binding]; other site 903814010486 L5 interface [polypeptide binding]; other site 903814010487 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 903814010488 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 903814010489 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 903814010490 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 903814010491 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 903814010492 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 903814010493 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 903814010494 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 903814010495 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 903814010496 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 903814010497 RNA binding site [nucleotide binding]; other site 903814010498 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 903814010499 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 903814010500 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 903814010501 23S rRNA interface [nucleotide binding]; other site 903814010502 putative translocon interaction site; other site 903814010503 signal recognition particle (SRP54) interaction site; other site 903814010504 L23 interface [polypeptide binding]; other site 903814010505 trigger factor interaction site; other site 903814010506 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 903814010507 23S rRNA interface [nucleotide binding]; other site 903814010508 5S rRNA interface [nucleotide binding]; other site 903814010509 putative antibiotic binding site [chemical binding]; other site 903814010510 L25 interface [polypeptide binding]; other site 903814010511 L27 interface [polypeptide binding]; other site 903814010512 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 903814010513 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 903814010514 G-X-X-G motif; other site 903814010515 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 903814010516 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 903814010517 putative translocon binding site; other site 903814010518 protein-rRNA interface [nucleotide binding]; other site 903814010519 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 903814010520 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 903814010521 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 903814010522 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 903814010523 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 903814010524 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 903814010525 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 903814010526 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 903814010527 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814010528 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814010529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814010530 Coenzyme A binding pocket [chemical binding]; other site 903814010531 elongation factor Tu; Reviewed; Region: PRK00049 903814010532 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 903814010533 G1 box; other site 903814010534 GEF interaction site [polypeptide binding]; other site 903814010535 GTP/Mg2+ binding site [chemical binding]; other site 903814010536 Switch I region; other site 903814010537 G2 box; other site 903814010538 G3 box; other site 903814010539 Switch II region; other site 903814010540 G4 box; other site 903814010541 G5 box; other site 903814010542 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 903814010543 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 903814010544 Antibiotic Binding Site [chemical binding]; other site 903814010545 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 903814010546 DNA-binding site [nucleotide binding]; DNA binding site 903814010547 RNA-binding motif; other site 903814010548 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814010549 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 903814010550 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 903814010551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 903814010552 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 903814010553 YacP-like NYN domain; Region: NYN_YacP; pfam05991 903814010554 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 903814010555 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 903814010556 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 903814010557 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 903814010558 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 903814010559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 903814010560 histidyl-tRNA synthetase; Region: hisS; TIGR00442 903814010561 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 903814010562 dimer interface [polypeptide binding]; other site 903814010563 motif 1; other site 903814010564 active site 903814010565 motif 2; other site 903814010566 motif 3; other site 903814010567 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 903814010568 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 903814010569 active site 903814010570 HIGH motif; other site 903814010571 dimer interface [polypeptide binding]; other site 903814010572 KMSKS motif; other site 903814010573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 903814010574 RNA binding surface [nucleotide binding]; other site 903814010575 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 903814010576 Domain of unknown function DUF20; Region: UPF0118; pfam01594 903814010577 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 903814010578 Transcriptional regulators [Transcription]; Region: FadR; COG2186 903814010579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814010580 DNA-binding site [nucleotide binding]; DNA binding site 903814010581 FCD domain; Region: FCD; pfam07729 903814010582 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 903814010583 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 903814010584 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 903814010585 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814010586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814010587 motif II; other site 903814010588 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 903814010589 ligand binding site [chemical binding]; other site 903814010590 active site 903814010591 UGI interface [polypeptide binding]; other site 903814010592 catalytic site [active] 903814010593 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 903814010594 active site 903814010595 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 903814010596 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 903814010597 active site 903814010598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 903814010599 metal ion-dependent adhesion site (MIDAS); other site 903814010600 MoxR-like ATPases [General function prediction only]; Region: COG0714 903814010601 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 903814010602 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 903814010603 metal ion-dependent adhesion site (MIDAS); other site 903814010604 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 903814010605 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814010606 P-loop; other site 903814010607 Magnesium ion binding site [ion binding]; other site 903814010608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814010609 Magnesium ion binding site [ion binding]; other site 903814010610 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 903814010611 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 903814010612 putative hexamer interface [polypeptide binding]; other site 903814010613 putative hexagonal pore; other site 903814010614 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 903814010615 putative hexamer interface [polypeptide binding]; other site 903814010616 putative hexagonal pore; other site 903814010617 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 903814010618 SLBB domain; Region: SLBB; pfam10531 903814010619 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 903814010620 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 903814010621 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 903814010622 putative catalytic cysteine [active] 903814010623 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 903814010624 Domain of unknown function (DUF336); Region: DUF336; pfam03928 903814010625 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 903814010626 Hexamer/Pentamer interface [polypeptide binding]; other site 903814010627 central pore; other site 903814010628 Flavoprotein; Region: Flavoprotein; cl08021 903814010629 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 903814010630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 903814010631 nucleotide binding site [chemical binding]; other site 903814010632 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 903814010633 Propanediol utilisation protein PduL; Region: PduL; pfam06130 903814010634 Propanediol utilisation protein PduL; Region: PduL; pfam06130 903814010635 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 903814010636 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 903814010637 Hexamer interface [polypeptide binding]; other site 903814010638 Hexagonal pore residue; other site 903814010639 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 903814010640 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 903814010641 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 903814010642 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 903814010643 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 903814010644 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 903814010645 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 903814010646 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 903814010647 alpha-beta subunit interface [polypeptide binding]; other site 903814010648 alpha-gamma subunit interface [polypeptide binding]; other site 903814010649 active site 903814010650 substrate and K+ binding site; other site 903814010651 K+ binding site [ion binding]; other site 903814010652 cobalamin binding site [chemical binding]; other site 903814010653 propanediol utilization protein PduB; Provisional; Region: PRK15415 903814010654 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 903814010655 putative hexamer interface [polypeptide binding]; other site 903814010656 putative hexagonal pore; other site 903814010657 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 903814010658 Hexamer interface [polypeptide binding]; other site 903814010659 Hexagonal pore residue; other site 903814010660 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 903814010661 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 903814010662 Hexamer interface [polypeptide binding]; other site 903814010663 Putative hexagonal pore residue; other site 903814010664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814010665 active site 903814010666 phosphorylation site [posttranslational modification] 903814010667 intermolecular recognition site; other site 903814010668 dimerization interface [polypeptide binding]; other site 903814010669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814010670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814010671 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 903814010672 Sensory domain found in PocR; Region: PocR; pfam10114 903814010673 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 903814010674 Histidine kinase; Region: His_kinase; pfam06580 903814010675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814010676 ATP binding site [chemical binding]; other site 903814010677 Mg2+ binding site [ion binding]; other site 903814010678 G-X-G motif; other site 903814010679 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 903814010680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814010681 dimerization interface [polypeptide binding]; other site 903814010682 putative Zn2+ binding site [ion binding]; other site 903814010683 putative DNA binding site [nucleotide binding]; other site 903814010684 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 903814010685 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 903814010686 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 903814010687 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814010688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814010689 motif I; other site 903814010690 motif II; other site 903814010691 BCCT family transporter; Region: BCCT; pfam02028 903814010692 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814010693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814010694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814010695 putative substrate translocation pore; other site 903814010696 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814010697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814010698 DNA-binding site [nucleotide binding]; DNA binding site 903814010699 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814010700 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814010701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814010702 DNA-binding site [nucleotide binding]; DNA binding site 903814010703 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814010704 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814010705 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814010706 B12 binding site [chemical binding]; other site 903814010707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814010708 S-adenosylmethionine binding site [chemical binding]; other site 903814010709 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 903814010710 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 903814010711 putative acyl-acceptor binding pocket; other site 903814010712 NAD synthetase; Reviewed; Region: nadE; PRK02628 903814010713 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 903814010714 multimer interface [polypeptide binding]; other site 903814010715 active site 903814010716 catalytic triad [active] 903814010717 protein interface 1 [polypeptide binding]; other site 903814010718 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 903814010719 homodimer interface [polypeptide binding]; other site 903814010720 NAD binding pocket [chemical binding]; other site 903814010721 ATP binding pocket [chemical binding]; other site 903814010722 Mg binding site [ion binding]; other site 903814010723 active-site loop [active] 903814010724 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 903814010725 iron-sulfur cluster [ion binding]; other site 903814010726 [2Fe-2S] cluster binding site [ion binding]; other site 903814010727 CTP synthetase; Validated; Region: pyrG; PRK05380 903814010728 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 903814010729 Catalytic site [active] 903814010730 active site 903814010731 UTP binding site [chemical binding]; other site 903814010732 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 903814010733 active site 903814010734 putative oxyanion hole; other site 903814010735 catalytic triad [active] 903814010736 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 903814010737 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 903814010738 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010739 domain interaction interfaces [polypeptide binding]; other site 903814010740 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010741 domain interaction interfaces [polypeptide binding]; other site 903814010742 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010743 domain interaction interfaces [polypeptide binding]; other site 903814010744 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010745 domain interaction interfaces [polypeptide binding]; other site 903814010746 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010747 domain interaction interfaces [polypeptide binding]; other site 903814010748 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010749 domain interaction interfaces [polypeptide binding]; other site 903814010750 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010751 domain interaction interfaces [polypeptide binding]; other site 903814010752 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 903814010753 domain interaction interfaces [polypeptide binding]; other site 903814010754 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 903814010755 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 903814010756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814010757 non-specific DNA binding site [nucleotide binding]; other site 903814010758 salt bridge; other site 903814010759 sequence-specific DNA binding site [nucleotide binding]; other site 903814010760 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 903814010761 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 903814010762 PYR/PP interface [polypeptide binding]; other site 903814010763 dimer interface [polypeptide binding]; other site 903814010764 TPP binding site [chemical binding]; other site 903814010765 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 903814010766 transketolase; Reviewed; Region: PRK05899 903814010767 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 903814010768 TPP-binding site [chemical binding]; other site 903814010769 dimer interface [polypeptide binding]; other site 903814010770 Uncharacterized conserved protein [Function unknown]; Region: COG1284 903814010771 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 903814010772 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 903814010773 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 903814010774 alanine racemase; Reviewed; Region: alr; PRK00053 903814010775 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 903814010776 active site 903814010777 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 903814010778 dimer interface [polypeptide binding]; other site 903814010779 substrate binding site [chemical binding]; other site 903814010780 catalytic residues [active] 903814010781 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 903814010782 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 903814010783 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 903814010784 homotrimer interaction site [polypeptide binding]; other site 903814010785 zinc binding site [ion binding]; other site 903814010786 CDP-binding sites; other site 903814010787 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 903814010788 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 903814010789 putative ATP binding site [chemical binding]; other site 903814010790 putative substrate interface [chemical binding]; other site 903814010791 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 903814010792 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 903814010793 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 903814010794 active site 903814010795 HIGH motif; other site 903814010796 KMSK motif region; other site 903814010797 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 903814010798 tRNA binding surface [nucleotide binding]; other site 903814010799 anticodon binding site; other site 903814010800 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 903814010801 Uncharacterized conserved protein [Function unknown]; Region: COG1683 903814010802 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 903814010803 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 903814010804 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 903814010805 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 903814010806 putative trimer interface [polypeptide binding]; other site 903814010807 putative CoA binding site [chemical binding]; other site 903814010808 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 903814010809 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 903814010810 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 903814010811 active site 903814010812 substrate binding site [chemical binding]; other site 903814010813 metal binding site [ion binding]; metal-binding site 903814010814 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 903814010815 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 903814010816 active site 903814010817 tetramer interface; other site 903814010818 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 903814010819 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 903814010820 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 903814010821 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 903814010822 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 903814010823 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 903814010824 putative active site [active] 903814010825 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 903814010826 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 903814010827 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 903814010828 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 903814010829 active site 903814010830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814010831 PAS fold; Region: PAS_3; pfam08447 903814010832 putative active site [active] 903814010833 heme pocket [chemical binding]; other site 903814010834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814010835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814010836 metal binding site [ion binding]; metal-binding site 903814010837 active site 903814010838 I-site; other site 903814010839 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 903814010840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814010841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814010842 non-specific DNA binding site [nucleotide binding]; other site 903814010843 salt bridge; other site 903814010844 sequence-specific DNA binding site [nucleotide binding]; other site 903814010845 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 903814010846 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 903814010847 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 903814010848 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 903814010849 PilX N-terminal; Region: PilX_N; pfam14341 903814010850 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 903814010851 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 903814010852 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 903814010853 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 903814010854 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 903814010855 four helix bundle protein; Region: TIGR02436 903814010856 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 903814010857 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 903814010858 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 903814010859 O-Antigen ligase; Region: Wzy_C; pfam04932 903814010860 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 903814010861 PAS domain S-box; Region: sensory_box; TIGR00229 903814010862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814010863 putative active site [active] 903814010864 heme pocket [chemical binding]; other site 903814010865 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814010866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814010867 metal binding site [ion binding]; metal-binding site 903814010868 active site 903814010869 I-site; other site 903814010870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814010871 metal binding site [ion binding]; metal-binding site 903814010872 active site 903814010873 I-site; other site 903814010874 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814010875 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 903814010876 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 903814010877 Walker A motif; other site 903814010878 ATP binding site [chemical binding]; other site 903814010879 Walker B motif; other site 903814010880 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 903814010881 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 903814010882 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 903814010883 Walker A motif; other site 903814010884 ATP binding site [chemical binding]; other site 903814010885 Walker B motif; other site 903814010886 intracellular protease, PfpI family; Region: PfpI; TIGR01382 903814010887 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 903814010888 proposed catalytic triad [active] 903814010889 conserved cys residue [active] 903814010890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814010891 substrate binding pocket [chemical binding]; other site 903814010892 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814010893 membrane-bound complex binding site; other site 903814010894 hinge residues; other site 903814010895 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 903814010896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814010897 metal binding site [ion binding]; metal-binding site 903814010898 active site 903814010899 I-site; other site 903814010900 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 903814010901 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 903814010902 putative dimer interface [polypeptide binding]; other site 903814010903 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 903814010904 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 903814010905 heterodimer interface [polypeptide binding]; other site 903814010906 active site 903814010907 FMN binding site [chemical binding]; other site 903814010908 homodimer interface [polypeptide binding]; other site 903814010909 substrate binding site [chemical binding]; other site 903814010910 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 903814010911 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 903814010912 FAD binding pocket [chemical binding]; other site 903814010913 FAD binding motif [chemical binding]; other site 903814010914 phosphate binding motif [ion binding]; other site 903814010915 beta-alpha-beta structure motif; other site 903814010916 NAD binding pocket [chemical binding]; other site 903814010917 Iron coordination center [ion binding]; other site 903814010918 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 903814010919 active site 903814010920 dimer interface [polypeptide binding]; other site 903814010921 dihydroorotase; Validated; Region: pyrC; PRK09357 903814010922 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 903814010923 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 903814010924 active site 903814010925 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 903814010926 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 903814010927 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 903814010928 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 903814010929 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 903814010930 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 903814010931 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 903814010932 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 903814010933 B12 binding domain; Region: B12-binding_2; cl03653 903814010934 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 903814010935 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814010936 B12 binding site [chemical binding]; other site 903814010937 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814010938 B12 binding site [chemical binding]; other site 903814010939 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814010940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814010941 DNA-binding site [nucleotide binding]; DNA binding site 903814010942 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814010943 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 903814010944 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 903814010945 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 903814010946 active site 903814010947 catalytic site [active] 903814010948 elongation factor Tu; Reviewed; Region: PRK00049 903814010949 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 903814010950 G1 box; other site 903814010951 GEF interaction site [polypeptide binding]; other site 903814010952 GTP/Mg2+ binding site [chemical binding]; other site 903814010953 Switch I region; other site 903814010954 G2 box; other site 903814010955 G3 box; other site 903814010956 Switch II region; other site 903814010957 G4 box; other site 903814010958 G5 box; other site 903814010959 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 903814010960 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 903814010961 Antibiotic Binding Site [chemical binding]; other site 903814010962 elongation factor G; Reviewed; Region: PRK00007 903814010963 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 903814010964 G1 box; other site 903814010965 putative GEF interaction site [polypeptide binding]; other site 903814010966 GTP/Mg2+ binding site [chemical binding]; other site 903814010967 Switch I region; other site 903814010968 G2 box; other site 903814010969 G3 box; other site 903814010970 Switch II region; other site 903814010971 G4 box; other site 903814010972 G5 box; other site 903814010973 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 903814010974 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 903814010975 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 903814010976 30S ribosomal protein S7; Validated; Region: PRK05302 903814010977 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 903814010978 S17 interaction site [polypeptide binding]; other site 903814010979 S8 interaction site; other site 903814010980 16S rRNA interaction site [nucleotide binding]; other site 903814010981 streptomycin interaction site [chemical binding]; other site 903814010982 23S rRNA interaction site [nucleotide binding]; other site 903814010983 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 903814010984 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 903814010985 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 903814010986 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 903814010987 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 903814010988 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 903814010989 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 903814010990 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 903814010991 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 903814010992 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 903814010993 G-loop; other site 903814010994 DNA binding site [nucleotide binding] 903814010995 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 903814010996 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 903814010997 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 903814010998 RPB1 interaction site [polypeptide binding]; other site 903814010999 RPB10 interaction site [polypeptide binding]; other site 903814011000 RPB11 interaction site [polypeptide binding]; other site 903814011001 RPB3 interaction site [polypeptide binding]; other site 903814011002 RPB12 interaction site [polypeptide binding]; other site 903814011003 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 903814011004 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 903814011005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814011006 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814011007 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 903814011008 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814011009 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011010 Amino acid permease; Region: AA_permease_2; pfam13520 903814011011 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 903814011012 MFS/sugar transport protein; Region: MFS_2; pfam13347 903814011013 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814011015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814011016 heat shock protein 90; Provisional; Region: PRK05218 903814011017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011018 ATP binding site [chemical binding]; other site 903814011019 Mg2+ binding site [ion binding]; other site 903814011020 G-X-G motif; other site 903814011021 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 903814011022 active site 903814011023 catalytic triad [active] 903814011024 oxyanion hole [active] 903814011025 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 903814011026 Class I aldolases; Region: Aldolase_Class_I; cl17187 903814011027 catalytic residue [active] 903814011028 Rubrerythrin [Energy production and conversion]; Region: COG1592 903814011029 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 903814011030 binuclear metal center [ion binding]; other site 903814011031 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 903814011032 iron binding site [ion binding]; other site 903814011033 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 903814011034 ANTAR domain; Region: ANTAR; pfam03861 903814011035 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 903814011036 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 903814011037 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 903814011038 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 903814011039 domain_subunit interface; other site 903814011040 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 903814011041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814011042 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 903814011043 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 903814011044 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 903814011045 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 903814011046 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 903814011047 active site 903814011048 FMN binding site [chemical binding]; other site 903814011049 substrate binding site [chemical binding]; other site 903814011050 3Fe-4S cluster binding site [ion binding]; other site 903814011051 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 903814011052 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 903814011053 putative active site [active] 903814011054 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 903814011055 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 903814011056 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 903814011057 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 903814011058 Nitrogen regulatory protein P-II; Region: P-II; smart00938 903814011059 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 903814011060 Maf-like protein; Region: Maf; pfam02545 903814011061 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 903814011062 active site 903814011063 dimer interface [polypeptide binding]; other site 903814011064 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 903814011065 EamA-like transporter family; Region: EamA; pfam00892 903814011066 EamA-like transporter family; Region: EamA; pfam00892 903814011067 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 903814011068 hypothetical protein; Provisional; Region: PRK02399 903814011069 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 903814011070 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 903814011071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814011073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011074 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 903814011075 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 903814011076 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 903814011077 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 903814011078 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 903814011079 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 903814011080 putative dimer interface [polypeptide binding]; other site 903814011081 active site pocket [active] 903814011082 putative cataytic base [active] 903814011083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814011084 S-adenosylmethionine binding site [chemical binding]; other site 903814011085 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 903814011086 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814011087 B12 binding site [chemical binding]; other site 903814011088 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 903814011089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814011090 FeS/SAM binding site; other site 903814011091 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814011092 B12 binding site [chemical binding]; other site 903814011093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814011094 Radical SAM superfamily; Region: Radical_SAM; pfam04055 903814011095 FeS/SAM binding site; other site 903814011096 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 903814011097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814011098 motif II; other site 903814011099 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 903814011100 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 903814011101 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 903814011102 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 903814011103 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814011104 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 903814011105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814011106 motif II; other site 903814011107 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 903814011108 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 903814011109 Part of AAA domain; Region: AAA_19; pfam13245 903814011110 Family description; Region: UvrD_C_2; pfam13538 903814011111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011112 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814011113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814011115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 903814011116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814011117 PAS domain; Region: PAS_9; pfam13426 903814011118 putative active site [active] 903814011119 heme pocket [chemical binding]; other site 903814011120 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 903814011121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814011122 Walker A motif; other site 903814011123 ATP binding site [chemical binding]; other site 903814011124 Walker B motif; other site 903814011125 arginine finger; other site 903814011126 Helix-turn-helix domain; Region: HTH_28; pfam13518 903814011127 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814011128 BCCT family transporter; Region: BCCT; cl00569 903814011129 BCCT family transporter; Region: BCCT; cl00569 903814011130 Domain of unknown function DUF11; Region: DUF11; cl17728 903814011131 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 903814011132 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 903814011133 active site 903814011134 catalytic site [active] 903814011135 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 903814011136 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 903814011137 NAD(P) binding site [chemical binding]; other site 903814011138 Uncharacterized conserved protein [Function unknown]; Region: COG1434 903814011139 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 903814011140 putative active site [active] 903814011141 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 903814011142 Penicillinase repressor; Region: Pencillinase_R; pfam03965 903814011143 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 903814011144 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 903814011145 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 903814011146 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 903814011147 GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519 903814011148 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 903814011149 ATP Binding subdomain [chemical binding]; other site 903814011150 Ligand Binding sites [chemical binding]; other site 903814011151 Dimerization subdomain; other site 903814011152 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 903814011153 active site 903814011154 Peptidase M15; Region: Peptidase_M15_3; cl01194 903814011155 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 903814011156 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 903814011157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814011158 DNA binding residues [nucleotide binding] 903814011159 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 903814011160 SnoaL-like domain; Region: SnoaL_3; pfam13474 903814011161 LytTr DNA-binding domain; Region: LytTR; smart00850 903814011162 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 903814011163 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 903814011164 active site 903814011165 DNA binding site [nucleotide binding] 903814011166 Int/Topo IB signature motif; other site 903814011167 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 903814011168 DNA-binding site [nucleotide binding]; DNA binding site 903814011169 RNA-binding motif; other site 903814011170 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 903814011171 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 903814011172 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 903814011173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814011174 Walker A/P-loop; other site 903814011175 ATP binding site [chemical binding]; other site 903814011176 Q-loop/lid; other site 903814011177 ABC transporter signature motif; other site 903814011178 Walker B; other site 903814011179 D-loop; other site 903814011180 H-loop/switch region; other site 903814011181 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 903814011182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814011183 Walker A/P-loop; other site 903814011184 ATP binding site [chemical binding]; other site 903814011185 Q-loop/lid; other site 903814011186 ABC transporter signature motif; other site 903814011187 Walker B; other site 903814011188 D-loop; other site 903814011189 H-loop/switch region; other site 903814011190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 903814011191 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 903814011192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011193 dimer interface [polypeptide binding]; other site 903814011194 conserved gate region; other site 903814011195 putative PBP binding loops; other site 903814011196 ABC-ATPase subunit interface; other site 903814011197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 903814011198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011199 dimer interface [polypeptide binding]; other site 903814011200 conserved gate region; other site 903814011201 putative PBP binding loops; other site 903814011202 ABC-ATPase subunit interface; other site 903814011203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814011204 S-adenosylmethionine binding site [chemical binding]; other site 903814011205 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 903814011206 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 903814011207 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 903814011208 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 903814011209 Asparaginase; Region: Asparaginase; pfam00710 903814011210 active site 903814011211 homodimer interface [polypeptide binding]; other site 903814011212 Predicted dehydrogenase [General function prediction only]; Region: COG0579 903814011213 hydroxyglutarate oxidase; Provisional; Region: PRK11728 903814011214 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 903814011215 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814011217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814011218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814011219 D-galactonate transporter; Region: 2A0114; TIGR00893 903814011220 putative substrate translocation pore; other site 903814011221 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 903814011222 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 903814011223 transmembrane helices; other site 903814011224 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 903814011225 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 903814011226 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011227 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814011229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814011230 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 903814011231 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 903814011232 Walker A/P-loop; other site 903814011233 ATP binding site [chemical binding]; other site 903814011234 Q-loop/lid; other site 903814011235 ABC transporter signature motif; other site 903814011236 Walker B; other site 903814011237 D-loop; other site 903814011238 H-loop/switch region; other site 903814011239 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 903814011240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011241 dimer interface [polypeptide binding]; other site 903814011242 conserved gate region; other site 903814011243 putative PBP binding loops; other site 903814011244 ABC-ATPase subunit interface; other site 903814011245 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 903814011246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 903814011247 substrate binding pocket [chemical binding]; other site 903814011248 membrane-bound complex binding site; other site 903814011249 hinge residues; other site 903814011250 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 903814011251 DAK2 domain; Region: Dak2; cl03685 903814011252 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 903814011253 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 903814011254 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 903814011255 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 903814011256 dimerization domain swap beta strand [polypeptide binding]; other site 903814011257 regulatory protein interface [polypeptide binding]; other site 903814011258 active site 903814011259 regulatory phosphorylation site [posttranslational modification]; other site 903814011260 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 903814011261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814011262 putative active site [active] 903814011263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814011264 putative active site [active] 903814011265 heme pocket [chemical binding]; other site 903814011266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814011267 Walker A motif; other site 903814011268 ATP binding site [chemical binding]; other site 903814011269 Walker B motif; other site 903814011270 arginine finger; other site 903814011271 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 903814011272 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 903814011273 triosephosphate isomerase; Provisional; Region: PRK14565 903814011274 substrate binding site [chemical binding]; other site 903814011275 dimer interface [polypeptide binding]; other site 903814011276 catalytic triad [active] 903814011277 Uncharacterized membrane protein [Function unknown]; Region: COG3949 903814011278 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 903814011279 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 903814011280 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 903814011281 phosphodiesterase YaeI; Provisional; Region: PRK11340 903814011282 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 903814011283 putative active site [active] 903814011284 putative metal binding site [ion binding]; other site 903814011285 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 903814011286 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 903814011287 Ligand binding site; other site 903814011288 Putative Catalytic site; other site 903814011289 DXD motif; other site 903814011290 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 903814011291 substrate binding site [chemical binding]; other site 903814011292 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 903814011293 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 903814011294 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 903814011295 polyphosphate kinase; Provisional; Region: PRK05443 903814011296 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 903814011297 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 903814011298 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 903814011299 putative domain interface [polypeptide binding]; other site 903814011300 putative active site [active] 903814011301 catalytic site [active] 903814011302 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 903814011303 putative domain interface [polypeptide binding]; other site 903814011304 putative active site [active] 903814011305 catalytic site [active] 903814011306 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 903814011307 Protein of unknown function (DUF554); Region: DUF554; pfam04474 903814011308 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 903814011309 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 903814011310 DNA binding residues [nucleotide binding] 903814011311 putative dimer interface [polypeptide binding]; other site 903814011312 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 903814011313 Rubredoxin; Region: Rubredoxin; pfam00301 903814011314 iron binding site [ion binding]; other site 903814011315 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 903814011316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 903814011317 nucleotide binding site [chemical binding]; other site 903814011318 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 903814011319 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 903814011320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 903814011321 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 903814011322 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 903814011323 endonuclease IV; Provisional; Region: PRK01060 903814011324 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 903814011325 AP (apurinic/apyrimidinic) site pocket; other site 903814011326 DNA interaction; other site 903814011327 Metal-binding active site; metal-binding site 903814011328 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 903814011329 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 903814011330 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 903814011331 active site 903814011332 Na/Ca binding site [ion binding]; other site 903814011333 catalytic site [active] 903814011334 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 903814011335 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 903814011336 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 903814011337 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 903814011338 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 903814011339 catalytic residues [active] 903814011340 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 903814011341 Catalytic site [active] 903814011342 Response regulator receiver domain; Region: Response_reg; pfam00072 903814011343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814011344 active site 903814011345 phosphorylation site [posttranslational modification] 903814011346 intermolecular recognition site; other site 903814011347 dimerization interface [polypeptide binding]; other site 903814011348 Histidine kinase; Region: His_kinase; pfam06580 903814011349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011350 ATP binding site [chemical binding]; other site 903814011351 Mg2+ binding site [ion binding]; other site 903814011352 G-X-G motif; other site 903814011353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 903814011354 metal binding site [ion binding]; metal-binding site 903814011355 active site 903814011356 I-site; other site 903814011357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 903814011358 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 903814011359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814011360 DNA-binding site [nucleotide binding]; DNA binding site 903814011361 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 903814011362 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 903814011363 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 903814011364 B12 binding site [chemical binding]; other site 903814011365 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 903814011366 EDD domain protein, DegV family; Region: DegV; TIGR00762 903814011367 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 903814011368 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 903814011369 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 903814011370 Cna protein B-type domain; Region: Cna_B; pfam05738 903814011371 Cna protein B-type domain; Region: Cna_B; pfam05738 903814011372 Cna protein B-type domain; Region: Cna_B; pfam05738 903814011373 Cna protein B-type domain; Region: Cna_B; pfam05738 903814011374 Cna protein B-type domain; Region: Cna_B; pfam05738 903814011375 Cna protein B-type domain; Region: Cna_B; pfam05738 903814011376 Transcriptional regulators [Transcription]; Region: MarR; COG1846 903814011377 MarR family; Region: MarR_2; pfam12802 903814011378 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 903814011379 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814011380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814011381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814011382 Walker A/P-loop; other site 903814011383 ATP binding site [chemical binding]; other site 903814011384 Q-loop/lid; other site 903814011385 ABC transporter signature motif; other site 903814011386 Walker B; other site 903814011387 D-loop; other site 903814011388 H-loop/switch region; other site 903814011389 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814011390 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 903814011391 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814011392 Walker A/P-loop; other site 903814011393 ATP binding site [chemical binding]; other site 903814011394 Q-loop/lid; other site 903814011395 ABC transporter signature motif; other site 903814011396 Walker B; other site 903814011397 D-loop; other site 903814011398 H-loop/switch region; other site 903814011399 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 903814011400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 903814011401 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 903814011402 catalytic residue [active] 903814011403 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 903814011404 catalytic residues [active] 903814011405 peroxiredoxin; Region: AhpC; TIGR03137 903814011406 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 903814011407 dimer interface [polypeptide binding]; other site 903814011408 decamer (pentamer of dimers) interface [polypeptide binding]; other site 903814011409 catalytic triad [active] 903814011410 peroxidatic and resolving cysteines [active] 903814011411 EamA-like transporter family; Region: EamA; pfam00892 903814011412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 903814011413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 903814011414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 903814011415 dimerization interface [polypeptide binding]; other site 903814011416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814011417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814011418 non-specific DNA binding site [nucleotide binding]; other site 903814011419 salt bridge; other site 903814011420 sequence-specific DNA binding site [nucleotide binding]; other site 903814011421 Accessory gene regulator B; Region: AgrB; pfam04647 903814011422 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 903814011423 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 903814011424 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 903814011425 ATP binding site [chemical binding]; other site 903814011426 Mg2+ binding site [ion binding]; other site 903814011427 G-X-G motif; other site 903814011428 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 903814011429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814011430 active site 903814011431 phosphorylation site [posttranslational modification] 903814011432 intermolecular recognition site; other site 903814011433 dimerization interface [polypeptide binding]; other site 903814011434 LytTr DNA-binding domain; Region: LytTR; pfam04397 903814011435 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814011436 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 903814011437 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 903814011438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814011439 Walker A/P-loop; other site 903814011440 ATP binding site [chemical binding]; other site 903814011441 Q-loop/lid; other site 903814011442 ABC transporter signature motif; other site 903814011443 Walker B; other site 903814011444 D-loop; other site 903814011445 H-loop/switch region; other site 903814011446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 903814011447 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814011448 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 903814011449 Walker A/P-loop; other site 903814011450 ATP binding site [chemical binding]; other site 903814011451 Q-loop/lid; other site 903814011452 ABC transporter signature motif; other site 903814011453 Walker B; other site 903814011454 D-loop; other site 903814011455 H-loop/switch region; other site 903814011456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 903814011457 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 903814011458 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 903814011459 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 903814011460 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 903814011461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011462 dimer interface [polypeptide binding]; other site 903814011463 conserved gate region; other site 903814011464 putative PBP binding loops; other site 903814011465 ABC-ATPase subunit interface; other site 903814011466 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 903814011467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011468 dimer interface [polypeptide binding]; other site 903814011469 conserved gate region; other site 903814011470 putative PBP binding loops; other site 903814011471 ABC-ATPase subunit interface; other site 903814011472 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 903814011473 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 903814011474 active site 903814011475 Zn binding site [ion binding]; other site 903814011476 Heavy-metal-associated domain; Region: HMA; pfam00403 903814011477 metal-binding site [ion binding] 903814011478 Heavy-metal-associated domain; Region: HMA; pfam00403 903814011479 metal-binding site [ion binding] 903814011480 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 903814011481 Heavy-metal-associated domain; Region: HMA; pfam00403 903814011482 metal-binding site [ion binding] 903814011483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814011484 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814011485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814011486 putative substrate translocation pore; other site 903814011487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814011488 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814011489 PAS domain; Region: PAS_9; pfam13426 903814011490 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 903814011491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814011492 Walker A motif; other site 903814011493 ATP binding site [chemical binding]; other site 903814011494 Walker B motif; other site 903814011495 PCI domain; Region: PCI; cl02111 903814011496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814011497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814011498 active site 903814011499 phosphorylation site [posttranslational modification] 903814011500 intermolecular recognition site; other site 903814011501 dimerization interface [polypeptide binding]; other site 903814011502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814011503 DNA binding site [nucleotide binding] 903814011504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814011505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 903814011506 dimerization interface [polypeptide binding]; other site 903814011507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814011508 dimer interface [polypeptide binding]; other site 903814011509 phosphorylation site [posttranslational modification] 903814011510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011511 ATP binding site [chemical binding]; other site 903814011512 Mg2+ binding site [ion binding]; other site 903814011513 G-X-G motif; other site 903814011514 hypothetical protein; Provisional; Region: PRK03881 903814011515 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 903814011516 AMMECR1; Region: AMMECR1; cl00911 903814011517 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 903814011518 sepiapterin reductase; Region: sepiapter_red; TIGR01500 903814011519 enolase; Provisional; Region: eno; PRK00077 903814011520 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 903814011521 dimer interface [polypeptide binding]; other site 903814011522 metal binding site [ion binding]; metal-binding site 903814011523 substrate binding pocket [chemical binding]; other site 903814011524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 903814011525 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 903814011526 acyl-activating enzyme (AAE) consensus motif; other site 903814011527 AMP binding site [chemical binding]; other site 903814011528 active site 903814011529 CoA binding site [chemical binding]; other site 903814011530 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 903814011531 Part of AAA domain; Region: AAA_19; pfam13245 903814011532 Family description; Region: UvrD_C_2; pfam13538 903814011533 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 903814011534 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 903814011535 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814011536 Walker A/P-loop; other site 903814011537 ATP binding site [chemical binding]; other site 903814011538 Q-loop/lid; other site 903814011539 ABC transporter signature motif; other site 903814011540 Walker B; other site 903814011541 D-loop; other site 903814011542 H-loop/switch region; other site 903814011543 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 903814011544 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 903814011545 active site 903814011546 NAD binding site [chemical binding]; other site 903814011547 metal binding site [ion binding]; metal-binding site 903814011548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814011549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814011550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814011551 Walker A/P-loop; other site 903814011552 ATP binding site [chemical binding]; other site 903814011553 Q-loop/lid; other site 903814011554 ABC transporter signature motif; other site 903814011555 Walker B; other site 903814011556 D-loop; other site 903814011557 H-loop/switch region; other site 903814011558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 903814011559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 903814011560 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 903814011561 Walker A/P-loop; other site 903814011562 ATP binding site [chemical binding]; other site 903814011563 Q-loop/lid; other site 903814011564 ABC transporter signature motif; other site 903814011565 Walker B; other site 903814011566 D-loop; other site 903814011567 H-loop/switch region; other site 903814011568 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 903814011569 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814011571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814011572 Uncharacterized conserved protein [Function unknown]; Region: COG0398 903814011573 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 903814011574 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 903814011575 Radical SAM superfamily; Region: Radical_SAM; pfam04055 903814011576 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 903814011577 ArsC family; Region: ArsC; pfam03960 903814011578 putative ArsC-like catalytic residues; other site 903814011579 putative TRX-like catalytic residues [active] 903814011580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 903814011581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814011582 Coenzyme A binding pocket [chemical binding]; other site 903814011583 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 903814011584 GIY-YIG motif/motif A; other site 903814011585 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 903814011586 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814011587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814011588 ABC transporter; Region: ABC_tran_2; pfam12848 903814011589 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 903814011590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814011591 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 903814011592 active site 903814011593 motif I; other site 903814011594 motif II; other site 903814011595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 903814011596 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 903814011597 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 903814011598 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 903814011599 Cl- selectivity filter; other site 903814011600 Cl- binding residues [ion binding]; other site 903814011601 pore gating glutamate residue; other site 903814011602 dimer interface [polypeptide binding]; other site 903814011603 H+/Cl- coupling transport residue; other site 903814011604 TrkA-C domain; Region: TrkA_C; pfam02080 903814011605 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 903814011606 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 903814011607 Walker A/P-loop; other site 903814011608 ATP binding site [chemical binding]; other site 903814011609 Q-loop/lid; other site 903814011610 ABC transporter signature motif; other site 903814011611 Walker B; other site 903814011612 D-loop; other site 903814011613 H-loop/switch region; other site 903814011614 TOBE domain; Region: TOBE_2; pfam08402 903814011615 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 903814011616 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 903814011617 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 903814011618 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 903814011619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011620 dimer interface [polypeptide binding]; other site 903814011621 conserved gate region; other site 903814011622 putative PBP binding loops; other site 903814011623 ABC-ATPase subunit interface; other site 903814011624 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 903814011625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011626 dimer interface [polypeptide binding]; other site 903814011627 conserved gate region; other site 903814011628 putative PBP binding loops; other site 903814011629 ABC-ATPase subunit interface; other site 903814011630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 903814011631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 903814011632 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 903814011633 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 903814011634 active site 903814011635 metal binding site [ion binding]; metal-binding site 903814011636 hexamer interface [polypeptide binding]; other site 903814011637 Transcriptional regulators [Transcription]; Region: GntR; COG1802 903814011638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814011639 DNA-binding site [nucleotide binding]; DNA binding site 903814011640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814011641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814011642 dimer interface [polypeptide binding]; other site 903814011643 phosphorylation site [posttranslational modification] 903814011644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011645 ATP binding site [chemical binding]; other site 903814011646 Mg2+ binding site [ion binding]; other site 903814011647 G-X-G motif; other site 903814011648 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814011649 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814011650 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 903814011651 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 903814011652 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814011653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814011654 Walker A/P-loop; other site 903814011655 ATP binding site [chemical binding]; other site 903814011656 Q-loop/lid; other site 903814011657 ABC transporter signature motif; other site 903814011658 Walker B; other site 903814011659 D-loop; other site 903814011660 H-loop/switch region; other site 903814011661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814011662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814011663 active site 903814011664 phosphorylation site [posttranslational modification] 903814011665 intermolecular recognition site; other site 903814011666 dimerization interface [polypeptide binding]; other site 903814011667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814011668 DNA binding site [nucleotide binding] 903814011669 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 903814011670 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 903814011671 G1 box; other site 903814011672 putative GEF interaction site [polypeptide binding]; other site 903814011673 GTP/Mg2+ binding site [chemical binding]; other site 903814011674 Switch I region; other site 903814011675 G2 box; other site 903814011676 G3 box; other site 903814011677 Switch II region; other site 903814011678 G4 box; other site 903814011679 G5 box; other site 903814011680 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 903814011681 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 903814011682 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 903814011683 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 903814011684 Aspartase; Region: Aspartase; cd01357 903814011685 active sites [active] 903814011686 tetramer interface [polypeptide binding]; other site 903814011687 EamA-like transporter family; Region: EamA; pfam00892 903814011688 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 903814011689 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 903814011690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814011691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814011692 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 903814011693 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814011694 putative ligand binding site [chemical binding]; other site 903814011695 putative NAD binding site [chemical binding]; other site 903814011696 catalytic site [active] 903814011697 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 903814011698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 903814011699 ATP binding site [chemical binding]; other site 903814011700 putative Mg++ binding site [ion binding]; other site 903814011701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 903814011702 nucleotide binding region [chemical binding]; other site 903814011703 ATP-binding site [chemical binding]; other site 903814011704 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 903814011705 HRDC domain; Region: HRDC; pfam00570 903814011706 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 903814011707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 903814011708 Zn2+ binding site [ion binding]; other site 903814011709 Mg2+ binding site [ion binding]; other site 903814011710 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 903814011711 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 903814011712 AzlC protein; Region: AzlC; cl00570 903814011713 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 903814011714 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 903814011715 reactive center loop; other site 903814011716 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 903814011717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 903814011718 putative DNA binding site [nucleotide binding]; other site 903814011719 putative Zn2+ binding site [ion binding]; other site 903814011720 AsnC family; Region: AsnC_trans_reg; pfam01037 903814011721 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 903814011722 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 903814011723 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 903814011724 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 903814011725 putative ligand binding site [chemical binding]; other site 903814011726 putative NAD binding site [chemical binding]; other site 903814011727 catalytic site [active] 903814011728 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 903814011729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814011730 Walker A/P-loop; other site 903814011731 ATP binding site [chemical binding]; other site 903814011732 Q-loop/lid; other site 903814011733 ABC transporter signature motif; other site 903814011734 Walker B; other site 903814011735 D-loop; other site 903814011736 H-loop/switch region; other site 903814011737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 903814011738 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 903814011739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 903814011740 Walker A/P-loop; other site 903814011741 ATP binding site [chemical binding]; other site 903814011742 Q-loop/lid; other site 903814011743 ABC transporter signature motif; other site 903814011744 Walker B; other site 903814011745 D-loop; other site 903814011746 H-loop/switch region; other site 903814011747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 903814011748 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 903814011749 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 903814011750 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 903814011751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011752 dimer interface [polypeptide binding]; other site 903814011753 conserved gate region; other site 903814011754 putative PBP binding loops; other site 903814011755 ABC-ATPase subunit interface; other site 903814011756 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 903814011757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 903814011758 dimer interface [polypeptide binding]; other site 903814011759 conserved gate region; other site 903814011760 putative PBP binding loops; other site 903814011761 ABC-ATPase subunit interface; other site 903814011762 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 903814011763 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 903814011764 Walker A/P-loop; other site 903814011765 ATP binding site [chemical binding]; other site 903814011766 Q-loop/lid; other site 903814011767 ABC transporter signature motif; other site 903814011768 Walker B; other site 903814011769 D-loop; other site 903814011770 H-loop/switch region; other site 903814011771 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 903814011772 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 903814011773 ABC-ATPase subunit interface; other site 903814011774 dimer interface [polypeptide binding]; other site 903814011775 putative PBP binding regions; other site 903814011776 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 903814011777 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 903814011778 putative metal binding site [ion binding]; other site 903814011779 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 903814011780 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 903814011781 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 903814011782 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 903814011783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814011784 S-adenosylmethionine binding site [chemical binding]; other site 903814011785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814011786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814011787 non-specific DNA binding site [nucleotide binding]; other site 903814011788 salt bridge; other site 903814011789 sequence-specific DNA binding site [nucleotide binding]; other site 903814011790 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 903814011791 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 903814011792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 903814011793 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 903814011794 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 903814011795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814011796 dimer interface [polypeptide binding]; other site 903814011797 phosphorylation site [posttranslational modification] 903814011798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011799 ATP binding site [chemical binding]; other site 903814011800 Mg2+ binding site [ion binding]; other site 903814011801 G-X-G motif; other site 903814011802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 903814011803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814011804 active site 903814011805 phosphorylation site [posttranslational modification] 903814011806 intermolecular recognition site; other site 903814011807 dimerization interface [polypeptide binding]; other site 903814011808 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 903814011809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 903814011810 FeS/SAM binding site; other site 903814011811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 903814011812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 903814011813 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 903814011814 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 903814011815 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 903814011816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814011817 Walker A/P-loop; other site 903814011818 ATP binding site [chemical binding]; other site 903814011819 Q-loop/lid; other site 903814011820 ABC transporter signature motif; other site 903814011821 Walker B; other site 903814011822 D-loop; other site 903814011823 H-loop/switch region; other site 903814011824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011825 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814011826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011827 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 903814011828 putative dimer interface [polypeptide binding]; other site 903814011829 catalytic triad [active] 903814011830 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 903814011831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 903814011832 Soluble P-type ATPase [General function prediction only]; Region: COG4087 903814011833 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 903814011834 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 903814011835 Walker A/P-loop; other site 903814011836 ATP binding site [chemical binding]; other site 903814011837 Q-loop/lid; other site 903814011838 ABC transporter signature motif; other site 903814011839 Walker B; other site 903814011840 D-loop; other site 903814011841 H-loop/switch region; other site 903814011842 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814011843 FtsX-like permease family; Region: FtsX; pfam02687 903814011844 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 903814011845 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 903814011846 FtsX-like permease family; Region: FtsX; pfam02687 903814011847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 903814011848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 903814011849 dimer interface [polypeptide binding]; other site 903814011850 phosphorylation site [posttranslational modification] 903814011851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011852 ATP binding site [chemical binding]; other site 903814011853 Mg2+ binding site [ion binding]; other site 903814011854 G-X-G motif; other site 903814011855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 903814011856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 903814011857 active site 903814011858 phosphorylation site [posttranslational modification] 903814011859 intermolecular recognition site; other site 903814011860 dimerization interface [polypeptide binding]; other site 903814011861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 903814011862 DNA binding site [nucleotide binding] 903814011863 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 903814011864 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 903814011865 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 903814011866 DNA binding residues [nucleotide binding] 903814011867 putative dimer interface [polypeptide binding]; other site 903814011868 Tubby C 2; Region: Tub_2; cl02043 903814011869 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 903814011870 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 903814011871 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 903814011872 DNA binding residues [nucleotide binding] 903814011873 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 903814011874 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 903814011875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 903814011876 Walker A/P-loop; other site 903814011877 ATP binding site [chemical binding]; other site 903814011878 Q-loop/lid; other site 903814011879 ABC transporter signature motif; other site 903814011880 Walker B; other site 903814011881 D-loop; other site 903814011882 H-loop/switch region; other site 903814011883 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 903814011884 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 903814011885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 903814011886 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 903814011887 substrate binding site [chemical binding]; other site 903814011888 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 903814011889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 903814011890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 903814011891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 903814011892 ATP binding site [chemical binding]; other site 903814011893 Mg2+ binding site [ion binding]; other site 903814011894 G-X-G motif; other site 903814011895 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 903814011896 triosephosphate isomerase; Provisional; Region: PRK04302 903814011897 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 903814011898 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 903814011899 intersubunit interface [polypeptide binding]; other site 903814011900 active site 903814011901 zinc binding site [ion binding]; other site 903814011902 Na+ binding site [ion binding]; other site 903814011903 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 903814011904 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 903814011905 substrate binding site [chemical binding]; other site 903814011906 hexamer interface [polypeptide binding]; other site 903814011907 metal binding site [ion binding]; metal-binding site 903814011908 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 903814011909 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 903814011910 nucleotide binding site [chemical binding]; other site 903814011911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 903814011912 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 903814011913 DNA binding residues [nucleotide binding] 903814011914 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 903814011915 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814011916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814011917 non-specific DNA binding site [nucleotide binding]; other site 903814011918 salt bridge; other site 903814011919 sequence-specific DNA binding site [nucleotide binding]; other site 903814011920 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814011921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814011922 non-specific DNA binding site [nucleotide binding]; other site 903814011923 salt bridge; other site 903814011924 sequence-specific DNA binding site [nucleotide binding]; other site 903814011925 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 903814011926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814011927 S-adenosylmethionine binding site [chemical binding]; other site 903814011928 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 903814011929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 903814011930 Coenzyme A binding pocket [chemical binding]; other site 903814011931 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 903814011932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 903814011933 Walker A/P-loop; other site 903814011934 ATP binding site [chemical binding]; other site 903814011935 Q-loop/lid; other site 903814011936 ABC transporter signature motif; other site 903814011937 Walker B; other site 903814011938 D-loop; other site 903814011939 H-loop/switch region; other site 903814011940 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 903814011941 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 903814011942 TM-ABC transporter signature motif; other site 903814011943 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 903814011944 zinc binding site [ion binding]; other site 903814011945 putative ligand binding site [chemical binding]; other site 903814011946 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 903814011947 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 903814011948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 903814011949 putative active site [active] 903814011950 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 903814011951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 903814011952 nucleotide binding site [chemical binding]; other site 903814011953 Domain of unknown function (DUF386); Region: DUF386; cl01047 903814011954 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 903814011955 Na binding site [ion binding]; other site 903814011956 N-acetylneuraminate lyase; Provisional; Region: PRK04147 903814011957 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 903814011958 inhibitor site; inhibition site 903814011959 active site 903814011960 dimer interface [polypeptide binding]; other site 903814011961 catalytic residue [active] 903814011962 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 903814011963 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 903814011964 putative active site cavity [active] 903814011965 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 903814011966 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 903814011967 active site 903814011968 trimer interface [polypeptide binding]; other site 903814011969 allosteric site; other site 903814011970 active site lid [active] 903814011971 hexamer (dimer of trimers) interface [polypeptide binding]; other site 903814011972 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 903814011973 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 903814011974 active site 903814011975 dimer interface [polypeptide binding]; other site 903814011976 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 903814011977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 903814011978 catalytic residues [active] 903814011979 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 903814011980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 903814011981 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 903814011982 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 903814011983 Walker A/P-loop; other site 903814011984 ATP binding site [chemical binding]; other site 903814011985 Q-loop/lid; other site 903814011986 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 903814011987 ABC transporter signature motif; other site 903814011988 Walker B; other site 903814011989 D-loop; other site 903814011990 H-loop/switch region; other site 903814011991 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 903814011992 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 903814011993 active site 903814011994 metal binding site [ion binding]; metal-binding site 903814011995 DNA binding site [nucleotide binding] 903814011996 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 903814011997 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 903814011998 Rubredoxin; Region: Rubredoxin; pfam00301 903814011999 iron binding site [ion binding]; other site 903814012000 EamA-like transporter family; Region: EamA; pfam00892 903814012001 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 903814012002 EamA-like transporter family; Region: EamA; pfam00892 903814012003 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 903814012004 Major Facilitator Superfamily; Region: MFS_1; pfam07690 903814012005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 903814012006 putative substrate translocation pore; other site 903814012007 BCCT family transporter; Region: BCCT; pfam02028 903814012008 BCCT family transporter; Region: BCCT; pfam02028 903814012009 PAS fold; Region: PAS_4; pfam08448 903814012010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 903814012011 putative active site [active] 903814012012 heme pocket [chemical binding]; other site 903814012013 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 903814012014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814012015 Walker A motif; other site 903814012016 ATP binding site [chemical binding]; other site 903814012017 Walker B motif; other site 903814012018 arginine finger; other site 903814012019 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 903814012020 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 903814012021 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814012022 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814012023 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814012024 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 903814012025 putative ADP-binding pocket [chemical binding]; other site 903814012026 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 903814012027 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814012028 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 903814012029 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 903814012030 NAD binding site [chemical binding]; other site 903814012031 substrate binding site [chemical binding]; other site 903814012032 homodimer interface [polypeptide binding]; other site 903814012033 active site 903814012034 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 903814012035 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 903814012036 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 903814012037 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 903814012038 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 903814012039 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 903814012040 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 903814012041 active site 903814012042 homodimer interface [polypeptide binding]; other site 903814012043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 903814012044 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 903814012045 NAD(P) binding site [chemical binding]; other site 903814012046 active site 903814012047 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 903814012048 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 903814012049 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 903814012050 NAD(P) binding site [chemical binding]; other site 903814012051 homodimer interface [polypeptide binding]; other site 903814012052 substrate binding site [chemical binding]; other site 903814012053 active site 903814012054 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 903814012055 putative glycosyl transferase; Provisional; Region: PRK10307 903814012056 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 903814012057 Bacterial sugar transferase; Region: Bac_transf; pfam02397 903814012058 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 903814012059 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 903814012060 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 903814012061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 903814012062 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 903814012063 Walker A motif; other site 903814012064 ATP binding site [chemical binding]; other site 903814012065 DNA polymerase III subunit delta'; Validated; Region: PRK07132 903814012066 arginine finger; other site 903814012067 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 903814012068 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 903814012069 TMP-binding site; other site 903814012070 ATP-binding site [chemical binding]; other site 903814012071 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 903814012072 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 903814012073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 903814012074 catalytic residue [active] 903814012075 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 903814012076 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 903814012077 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 903814012078 catalytic residues [active] 903814012079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814012080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814012081 non-specific DNA binding site [nucleotide binding]; other site 903814012082 salt bridge; other site 903814012083 sequence-specific DNA binding site [nucleotide binding]; other site 903814012084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 903814012085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 903814012086 non-specific DNA binding site [nucleotide binding]; other site 903814012087 salt bridge; other site 903814012088 sequence-specific DNA binding site [nucleotide binding]; other site 903814012089 Sulfatase; Region: Sulfatase; cl17466 903814012090 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 903814012091 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 903814012092 active site 903814012093 HIGH motif; other site 903814012094 KMSKS motif; other site 903814012095 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 903814012096 tRNA binding surface [nucleotide binding]; other site 903814012097 anticodon binding site; other site 903814012098 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 903814012099 dimer interface [polypeptide binding]; other site 903814012100 putative tRNA-binding site [nucleotide binding]; other site 903814012101 type III secretion system ATPase; Validated; Region: PRK05922 903814012102 Predicted methyltransferases [General function prediction only]; Region: COG0313 903814012103 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 903814012104 putative SAM binding site [chemical binding]; other site 903814012105 putative homodimer interface [polypeptide binding]; other site 903814012106 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 903814012107 replicative DNA helicase; Region: DnaB; TIGR00665 903814012108 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 903814012109 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 903814012110 Walker A motif; other site 903814012111 ATP binding site [chemical binding]; other site 903814012112 Walker B motif; other site 903814012113 DNA binding loops [nucleotide binding] 903814012114 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 903814012115 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 903814012116 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 903814012117 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 903814012118 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 903814012119 DHH family; Region: DHH; pfam01368 903814012120 DHHA1 domain; Region: DHHA1; pfam02272 903814012121 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 903814012122 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 903814012123 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 903814012124 dimerization interface [polypeptide binding]; other site 903814012125 domain crossover interface; other site 903814012126 redox-dependent activation switch; other site 903814012127 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 903814012128 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 903814012129 active site 903814012130 multimer interface [polypeptide binding]; other site 903814012131 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 903814012132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 903814012133 DNA-binding site [nucleotide binding]; DNA binding site 903814012134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 903814012135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 903814012136 homodimer interface [polypeptide binding]; other site 903814012137 catalytic residue [active] 903814012138 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 903814012139 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 903814012140 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 903814012141 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 903814012142 dimer interface [polypeptide binding]; other site 903814012143 ssDNA binding site [nucleotide binding]; other site 903814012144 tetramer (dimer of dimers) interface [polypeptide binding]; other site 903814012145 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 903814012146 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 903814012147 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 903814012148 Mechanosensitive ion channel; Region: MS_channel; pfam00924 903814012149 Colicin V production protein; Region: Colicin_V; pfam02674 903814012150 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532 903814012151 alpha-gamma subunit interface [polypeptide binding]; other site 903814012152 beta-gamma subunit interface [polypeptide binding]; other site 903814012153 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 903814012154 ParB-like nuclease domain; Region: ParB; smart00470 903814012155 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 903814012156 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814012157 P-loop; other site 903814012158 Magnesium ion binding site [ion binding]; other site 903814012159 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 903814012160 Magnesium ion binding site [ion binding]; other site 903814012161 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 903814012162 ParB-like nuclease domain; Region: ParBc; pfam02195 903814012163 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 903814012164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 903814012165 S-adenosylmethionine binding site [chemical binding]; other site 903814012166 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 903814012167 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 903814012168 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 903814012169 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 903814012170 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 903814012171 trmE is a tRNA modification GTPase; Region: trmE; cd04164 903814012172 G1 box; other site 903814012173 GTP/Mg2+ binding site [chemical binding]; other site 903814012174 Switch I region; other site 903814012175 G2 box; other site 903814012176 Switch II region; other site 903814012177 G3 box; other site 903814012178 G4 box; other site 903814012179 G5 box; other site 903814012180 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 903814012181 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 903814012182 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 903814012183 G-X-X-G motif; other site 903814012184 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 903814012185 RxxxH motif; other site 903814012186 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 903814012187 Haemolytic domain; Region: Haemolytic; pfam01809