-- dump date 20140619_092122 -- class Genbank::misc_feature -- table misc_feature_note -- id note 717961000001 potassium/proton antiporter; Reviewed; Region: PRK05326 717961000002 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 717961000003 TrkA-C domain; Region: TrkA_C; pfam02080 717961000004 TrkA-C domain; Region: TrkA_C; pfam02080 717961000005 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 717961000006 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 717961000007 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 717961000008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961000009 motif II; other site 717961000010 Acylphosphatase; Region: Acylphosphatase; pfam00708 717961000011 Cache domain; Region: Cache_1; pfam02743 717961000012 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717961000013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717961000014 dimer interface [polypeptide binding]; other site 717961000015 putative CheW interface [polypeptide binding]; other site 717961000016 peptide chain release factor 2; Validated; Region: prfB; PRK00578 717961000017 This domain is found in peptide chain release factors; Region: PCRF; smart00937 717961000018 RF-1 domain; Region: RF-1; pfam00472 717961000019 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 717961000020 TRAM domain; Region: TRAM; cl01282 717961000021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961000022 S-adenosylmethionine binding site [chemical binding]; other site 717961000023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717961000024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961000025 active site 717961000026 phosphorylation site [posttranslational modification] 717961000027 intermolecular recognition site; other site 717961000028 dimerization interface [polypeptide binding]; other site 717961000029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717961000030 DNA binding site [nucleotide binding] 717961000031 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 717961000032 VanW like protein; Region: VanW; pfam04294 717961000033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961000034 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 717961000035 Coenzyme A binding pocket [chemical binding]; other site 717961000036 Rubrerythrin [Energy production and conversion]; Region: COG1592 717961000037 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 717961000038 binuclear metal center [ion binding]; other site 717961000039 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 717961000040 iron binding site [ion binding]; other site 717961000041 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 717961000042 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 717961000043 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 717961000044 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 717961000045 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 717961000046 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717961000047 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 717961000048 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 717961000049 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 717961000050 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 717961000051 active site 717961000052 nucleophile elbow; other site 717961000053 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 717961000054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961000055 S-adenosylmethionine binding site [chemical binding]; other site 717961000056 Penicillinase repressor; Region: Pencillinase_R; cl17580 717961000057 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 717961000058 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 717961000059 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 717961000060 Protein of unknown function; Region: DUF3658; pfam12395 717961000061 CHC2 zinc finger; Region: zf-CHC2; cl17510 717961000062 D5 N terminal like; Region: D5_N; pfam08706 717961000063 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 717961000064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717961000065 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 717961000066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 717961000067 non-specific DNA binding site [nucleotide binding]; other site 717961000068 salt bridge; other site 717961000069 sequence-specific DNA binding site [nucleotide binding]; other site 717961000070 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 717961000071 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961000072 catalytic residues [active] 717961000073 Recombinase; Region: Recombinase; pfam07508 717961000074 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961000075 Transposase, Mutator family; Region: Transposase_mut; pfam00872 717961000076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961000077 Walker A motif; other site 717961000078 ATP binding site [chemical binding]; other site 717961000079 Walker B motif; other site 717961000080 arginine finger; other site 717961000081 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 717961000082 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717961000083 metal ion-dependent adhesion site (MIDAS); other site 717961000084 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961000085 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961000086 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 717961000087 non-specific DNA binding site [nucleotide binding]; other site 717961000088 salt bridge; other site 717961000089 sequence-specific DNA binding site [nucleotide binding]; other site 717961000090 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 717961000091 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 717961000092 Methyltransferase domain; Region: Methyltransf_26; pfam13659 717961000093 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 717961000094 HipA-like C-terminal domain; Region: HipA_C; pfam07804 717961000095 TIGR02687 family protein; Region: TIGR02687 717961000096 PglZ domain; Region: PglZ; pfam08665 717961000097 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 717961000098 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 717961000099 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 717961000100 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961000101 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 717961000102 VanZ like family; Region: VanZ; cl01971 717961000103 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 717961000104 active site 717961000105 metal binding site [ion binding]; metal-binding site 717961000106 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 717961000107 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 717961000108 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 717961000109 putative metal binding residues [ion binding]; other site 717961000110 signature motif; other site 717961000111 dimer interface [polypeptide binding]; other site 717961000112 active site 717961000113 polyP binding site; other site 717961000114 substrate binding site [chemical binding]; other site 717961000115 acceptor-phosphate pocket; other site 717961000116 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 717961000117 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 717961000118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717961000119 Domain of unknown function (DUF368); Region: DUF368; cl00893 717961000120 Domain of unknown function (DUF368); Region: DUF368; pfam04018 717961000121 Predicted membrane protein [Function unknown]; Region: COG4905 717961000122 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 717961000123 linker region; other site 717961000124 Spectrin repeats; Region: SPEC; smart00150 717961000125 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 717961000126 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 717961000127 Ligand binding site; other site 717961000128 Putative Catalytic site; other site 717961000129 DXD motif; other site 717961000130 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 717961000131 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 717961000132 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717961000133 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 717961000134 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 717961000135 Haemolytic domain; Region: Haemolytic; pfam01809 717961000136 Ribonuclease P; Region: Ribonuclease_P; cl00457 717961000137 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 717961000138 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 717961000139 active site 717961000140 catalytic triad [active] 717961000141 oxyanion hole [active] 717961000142 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 717961000143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717961000144 dimer interface [polypeptide binding]; other site 717961000145 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 717961000146 putative CheW interface [polypeptide binding]; other site 717961000147 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 717961000148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961000149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961000150 DNA binding residues [nucleotide binding] 717961000151 FeoA domain; Region: FeoA; pfam04023 717961000152 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 717961000153 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 717961000154 G1 box; other site 717961000155 GTP/Mg2+ binding site [chemical binding]; other site 717961000156 Switch I region; other site 717961000157 G2 box; other site 717961000158 G3 box; other site 717961000159 Switch II region; other site 717961000160 G4 box; other site 717961000161 G5 box; other site 717961000162 Nucleoside recognition; Region: Gate; pfam07670 717961000163 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 717961000164 Nucleoside recognition; Region: Gate; pfam07670 717961000165 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 717961000166 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 717961000167 hypothetical protein; Provisional; Region: PRK09609 717961000168 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 717961000169 6-phosphofructokinase; Provisional; Region: PRK03202 717961000170 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 717961000171 active site 717961000172 ADP/pyrophosphate binding site [chemical binding]; other site 717961000173 dimerization interface [polypeptide binding]; other site 717961000174 allosteric effector site; other site 717961000175 fructose-1,6-bisphosphate binding site; other site 717961000176 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 717961000177 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 717961000178 shikimate kinase; Provisional; Region: PRK13947 717961000179 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 717961000180 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 717961000181 nucleotide binding site [chemical binding]; other site 717961000182 putative hydrolase; Validated; Region: PRK09248 717961000183 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 717961000184 active site 717961000185 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 717961000186 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 717961000187 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 717961000188 Hpr binding site; other site 717961000189 active site 717961000190 homohexamer subunit interaction site [polypeptide binding]; other site 717961000191 Rubrerythrin [Energy production and conversion]; Region: COG1592 717961000192 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 717961000193 binuclear metal center [ion binding]; other site 717961000194 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 717961000195 iron binding site [ion binding]; other site 717961000196 Predicted membrane protein [Function unknown]; Region: COG1971 717961000197 Domain of unknown function DUF; Region: DUF204; pfam02659 717961000198 Domain of unknown function DUF; Region: DUF204; pfam02659 717961000199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961000200 Zn2+ binding site [ion binding]; other site 717961000201 Mg2+ binding site [ion binding]; other site 717961000202 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 717961000203 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 717961000204 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 717961000205 Double zinc ribbon; Region: DZR; pfam12773 717961000206 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 717961000207 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 717961000208 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 717961000209 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 717961000210 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 717961000211 ATP binding site [chemical binding]; other site 717961000212 Mg2+ binding site [ion binding]; other site 717961000213 G-X-G motif; other site 717961000214 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961000215 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961000216 metal binding site [ion binding]; metal-binding site 717961000217 active site 717961000218 I-site; other site 717961000219 stage II sporulation protein P; Region: spore_II_P; TIGR02867 717961000220 Germination protease; Region: Peptidase_A25; cl04057 717961000221 hypothetical protein; Provisional; Region: PRK05473 717961000222 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 717961000223 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 717961000224 FIC domain binding interface [polypeptide binding]; other site 717961000225 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 717961000226 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 717961000227 dimer interface [polypeptide binding]; other site 717961000228 active site 717961000229 metal binding site [ion binding]; metal-binding site 717961000230 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 717961000231 EamA-like transporter family; Region: EamA; pfam00892 717961000232 EamA-like transporter family; Region: EamA; pfam00892 717961000233 stage II sporulation protein E; Region: spore_II_E; TIGR02865 717961000234 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 717961000235 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 717961000236 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 717961000237 Ligand Binding Site [chemical binding]; other site 717961000238 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 717961000239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961000240 S-adenosylmethionine binding site [chemical binding]; other site 717961000241 putative glycosyl transferase; Provisional; Region: PRK10073 717961000242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717961000243 active site 717961000244 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 717961000245 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717961000246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717961000247 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 717961000248 active site 717961000249 nucleotide binding site [chemical binding]; other site 717961000250 HIGH motif; other site 717961000251 KMSKS motif; other site 717961000252 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 717961000253 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 717961000254 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 717961000255 putative ADP-binding pocket [chemical binding]; other site 717961000256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717961000257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717961000258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 717961000259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 717961000260 DNA binding site [nucleotide binding] 717961000261 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 717961000262 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 717961000263 ring oligomerisation interface [polypeptide binding]; other site 717961000264 ATP/Mg binding site [chemical binding]; other site 717961000265 stacking interactions; other site 717961000266 hinge regions; other site 717961000267 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 717961000268 inhibitor binding site; inhibition site 717961000269 active site 717961000270 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 717961000271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717961000272 acyl-activating enzyme (AAE) consensus motif; other site 717961000273 AMP binding site [chemical binding]; other site 717961000274 active site 717961000275 CoA binding site [chemical binding]; other site 717961000276 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 717961000277 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961000278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961000279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961000280 DNA binding residues [nucleotide binding] 717961000281 Predicted membrane protein [Function unknown]; Region: COG2510 717961000282 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 717961000283 Predicted membrane protein [Function unknown]; Region: COG2510 717961000284 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 717961000285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961000286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961000287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961000288 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 717961000289 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 717961000290 catalytic domain interface [polypeptide binding]; other site 717961000291 homodimer interface [polypeptide binding]; other site 717961000292 putative active site [active] 717961000293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961000294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961000295 non-specific DNA binding site [nucleotide binding]; other site 717961000296 salt bridge; other site 717961000297 sequence-specific DNA binding site [nucleotide binding]; other site 717961000298 Predicted membrane protein [Function unknown]; Region: COG1511 717961000299 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 717961000300 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 717961000301 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 717961000302 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 717961000303 heterodimer interface [polypeptide binding]; other site 717961000304 active site 717961000305 FMN binding site [chemical binding]; other site 717961000306 homodimer interface [polypeptide binding]; other site 717961000307 substrate binding site [chemical binding]; other site 717961000308 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 717961000309 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 717961000310 FAD binding pocket [chemical binding]; other site 717961000311 FAD binding motif [chemical binding]; other site 717961000312 phosphate binding motif [ion binding]; other site 717961000313 beta-alpha-beta structure motif; other site 717961000314 NAD binding pocket [chemical binding]; other site 717961000315 Iron coordination center [ion binding]; other site 717961000316 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 717961000317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717961000318 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 717961000319 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 717961000320 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717961000321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717961000322 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 717961000323 IMP binding site; other site 717961000324 dimer interface [polypeptide binding]; other site 717961000325 interdomain contacts; other site 717961000326 partial ornithine binding site; other site 717961000327 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 717961000328 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 717961000329 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 717961000330 catalytic site [active] 717961000331 subunit interface [polypeptide binding]; other site 717961000332 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 717961000333 active site 717961000334 dimer interface [polypeptide binding]; other site 717961000335 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 717961000336 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 717961000337 nudix motif; other site 717961000338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717961000339 catalytic core [active] 717961000340 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 717961000341 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717961000342 PYR/PP interface [polypeptide binding]; other site 717961000343 dimer interface [polypeptide binding]; other site 717961000344 TPP binding site [chemical binding]; other site 717961000345 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717961000346 transketolase; Reviewed; Region: PRK05899 717961000347 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 717961000348 TPP-binding site [chemical binding]; other site 717961000349 dimer interface [polypeptide binding]; other site 717961000350 Protein of unknown function (DUF554); Region: DUF554; pfam04474 717961000351 Probable zinc-binding domain; Region: zf-trcl; pfam13451 717961000352 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 717961000353 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 717961000354 Part of AAA domain; Region: AAA_19; pfam13245 717961000355 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 717961000356 AAA domain; Region: AAA_12; pfam13087 717961000357 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 717961000358 putative active site [active] 717961000359 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 717961000360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961000361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961000362 metal binding site [ion binding]; metal-binding site 717961000363 active site 717961000364 I-site; other site 717961000365 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717961000366 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717961000367 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 717961000368 putative dimer interface [polypeptide binding]; other site 717961000369 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717961000370 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 717961000371 putative dimer interface [polypeptide binding]; other site 717961000372 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 717961000373 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 717961000374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717961000375 catalytic residue [active] 717961000376 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 717961000377 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 717961000378 trimerization site [polypeptide binding]; other site 717961000379 active site 717961000380 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 717961000381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961000382 Coenzyme A binding pocket [chemical binding]; other site 717961000383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961000384 S-adenosylmethionine binding site [chemical binding]; other site 717961000385 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 717961000386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961000387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961000388 Walker A/P-loop; other site 717961000389 ATP binding site [chemical binding]; other site 717961000390 Q-loop/lid; other site 717961000391 ABC transporter signature motif; other site 717961000392 Walker B; other site 717961000393 D-loop; other site 717961000394 H-loop/switch region; other site 717961000395 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 717961000396 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 717961000397 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 717961000398 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 717961000399 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 717961000400 putative alpha-glucosidase; Provisional; Region: PRK10658 717961000401 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 717961000402 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 717961000403 active site 717961000404 homotrimer interface [polypeptide binding]; other site 717961000405 catalytic site [active] 717961000406 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 717961000407 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 717961000408 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 717961000409 dimer interface [polypeptide binding]; other site 717961000410 active site 717961000411 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 717961000412 Ligand Binding Site [chemical binding]; other site 717961000413 Molecular Tunnel; other site 717961000414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961000415 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961000416 salt bridge; other site 717961000417 non-specific DNA binding site [nucleotide binding]; other site 717961000418 sequence-specific DNA binding site [nucleotide binding]; other site 717961000419 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 717961000420 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 717961000421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961000422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961000423 non-specific DNA binding site [nucleotide binding]; other site 717961000424 salt bridge; other site 717961000425 sequence-specific DNA binding site [nucleotide binding]; other site 717961000426 myosin-cross-reactive antigen; Provisional; Region: PRK13977 717961000427 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 717961000428 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 717961000429 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 717961000430 Predicted transcriptional regulators [Transcription]; Region: COG1695 717961000431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717961000432 putative Zn2+ binding site [ion binding]; other site 717961000433 putative DNA binding site [nucleotide binding]; other site 717961000434 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 717961000435 putative ligand binding site [chemical binding]; other site 717961000436 putative NAD binding site [chemical binding]; other site 717961000437 putative catalytic site [active] 717961000438 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 717961000439 L-serine binding site [chemical binding]; other site 717961000440 ACT domain interface; other site 717961000441 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 717961000442 homodimer interface [polypeptide binding]; other site 717961000443 substrate-cofactor binding pocket; other site 717961000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961000445 catalytic residue [active] 717961000446 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961000447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961000448 non-specific DNA binding site [nucleotide binding]; other site 717961000449 salt bridge; other site 717961000450 sequence-specific DNA binding site [nucleotide binding]; other site 717961000451 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 717961000452 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 717961000453 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 717961000454 FAD binding pocket [chemical binding]; other site 717961000455 FAD binding motif [chemical binding]; other site 717961000456 phosphate binding motif [ion binding]; other site 717961000457 beta-alpha-beta structure motif; other site 717961000458 NAD binding pocket [chemical binding]; other site 717961000459 Iron coordination center [ion binding]; other site 717961000460 putative oxidoreductase; Provisional; Region: PRK12831 717961000461 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 717961000462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717961000463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717961000464 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961000465 Zn2+ binding site [ion binding]; other site 717961000466 Mg2+ binding site [ion binding]; other site 717961000467 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961000468 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 717961000469 Part of AAA domain; Region: AAA_19; pfam13245 717961000470 Family description; Region: UvrD_C_2; pfam13538 717961000471 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 717961000472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 717961000473 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 717961000474 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 717961000475 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 717961000476 glutaminase active site [active] 717961000477 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 717961000478 dimer interface [polypeptide binding]; other site 717961000479 active site 717961000480 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 717961000481 dimer interface [polypeptide binding]; other site 717961000482 active site 717961000483 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 717961000484 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 717961000485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717961000486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717961000487 catalytic residue [active] 717961000488 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 717961000489 Sulfate transporter family; Region: Sulfate_transp; pfam00916 717961000490 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 717961000491 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 717961000492 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 717961000493 RNA/DNA hybrid binding site [nucleotide binding]; other site 717961000494 active site 717961000495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717961000496 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 717961000497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961000498 motif II; other site 717961000499 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 717961000500 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717961000501 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 717961000502 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 717961000503 Walker A/P-loop; other site 717961000504 ATP binding site [chemical binding]; other site 717961000505 Q-loop/lid; other site 717961000506 ABC transporter signature motif; other site 717961000507 Walker B; other site 717961000508 D-loop; other site 717961000509 H-loop/switch region; other site 717961000510 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717961000511 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 717961000512 active site 717961000513 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 717961000514 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717961000515 putative ADP-binding pocket [chemical binding]; other site 717961000516 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 717961000517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961000518 FeS/SAM binding site; other site 717961000519 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 717961000520 Pyruvate formate lyase 1; Region: PFL1; cd01678 717961000521 coenzyme A binding site [chemical binding]; other site 717961000522 active site 717961000523 catalytic residues [active] 717961000524 glycine loop; other site 717961000525 ACT domain-containing protein [General function prediction only]; Region: COG4747 717961000526 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 717961000527 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 717961000528 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 717961000529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717961000530 acyl-activating enzyme (AAE) consensus motif; other site 717961000531 AMP binding site [chemical binding]; other site 717961000532 active site 717961000533 CoA binding site [chemical binding]; other site 717961000534 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 717961000535 Ligand Binding Site [chemical binding]; other site 717961000536 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961000537 FtsX-like permease family; Region: FtsX; pfam02687 717961000538 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961000539 FtsX-like permease family; Region: FtsX; pfam02687 717961000540 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717961000541 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717961000542 HlyD family secretion protein; Region: HlyD_3; pfam13437 717961000543 CTP synthetase; Validated; Region: pyrG; PRK05380 717961000544 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 717961000545 Catalytic site [active] 717961000546 active site 717961000547 UTP binding site [chemical binding]; other site 717961000548 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 717961000549 active site 717961000550 putative oxyanion hole; other site 717961000551 catalytic triad [active] 717961000552 polyphosphate kinase; Provisional; Region: PRK05443 717961000553 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 717961000554 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 717961000555 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 717961000556 putative active site [active] 717961000557 catalytic site [active] 717961000558 Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169 717961000559 putative domain interface [polypeptide binding]; other site 717961000560 putative active site [active] 717961000561 catalytic site [active] 717961000562 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 717961000563 Asp-box motif; other site 717961000564 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 717961000565 putative metal binding site [ion binding]; other site 717961000566 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 717961000567 heat shock protein 90; Provisional; Region: PRK05218 717961000568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961000569 ATP binding site [chemical binding]; other site 717961000570 Mg2+ binding site [ion binding]; other site 717961000571 G-X-G motif; other site 717961000572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717961000573 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 717961000574 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717961000575 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 717961000576 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 717961000577 Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432 717961000578 Tropomyosin like; Region: Tropomyosin_1; pfam12718 717961000579 FtsX-like permease family; Region: FtsX; pfam02687 717961000580 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717961000581 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961000582 FtsX-like permease family; Region: FtsX; pfam02687 717961000583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961000584 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961000585 Walker A/P-loop; other site 717961000586 ATP binding site [chemical binding]; other site 717961000587 Q-loop/lid; other site 717961000588 ABC transporter signature motif; other site 717961000589 Walker B; other site 717961000590 D-loop; other site 717961000591 H-loop/switch region; other site 717961000592 S-adenosylmethionine synthetase; Validated; Region: PRK05250 717961000593 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 717961000594 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 717961000595 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 717961000596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 717961000597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 717961000598 Coenzyme A binding pocket [chemical binding]; other site 717961000599 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 717961000600 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 717961000601 RimM N-terminal domain; Region: RimM; pfam01782 717961000602 PRC-barrel domain; Region: PRC; pfam05239 717961000603 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717961000604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961000605 motif II; other site 717961000606 Bacterial PH domain; Region: DUF304; pfam03703 717961000607 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 717961000608 ammonium transporter; Region: amt; TIGR00836 717961000609 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 717961000610 Nitrogen regulatory protein P-II; Region: P-II; smart00938 717961000611 Rhomboid family; Region: Rhomboid; cl11446 717961000612 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 717961000613 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 717961000614 active site 717961000615 HIGH motif; other site 717961000616 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 717961000617 KMSKS motif; other site 717961000618 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 717961000619 tRNA binding surface [nucleotide binding]; other site 717961000620 anticodon binding site; other site 717961000621 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 717961000622 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 717961000623 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 717961000624 trimer interface [polypeptide binding]; other site 717961000625 active site 717961000626 substrate binding site [chemical binding]; other site 717961000627 CoA binding site [chemical binding]; other site 717961000628 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717961000629 PAS domain; Region: PAS; smart00091 717961000630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717961000631 dimer interface [polypeptide binding]; other site 717961000632 phosphorylation site [posttranslational modification] 717961000633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961000634 ATP binding site [chemical binding]; other site 717961000635 Mg2+ binding site [ion binding]; other site 717961000636 G-X-G motif; other site 717961000637 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 717961000638 PhoU domain; Region: PhoU; pfam01895 717961000639 PhoU domain; Region: PhoU; pfam01895 717961000640 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 717961000641 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 717961000642 Walker A/P-loop; other site 717961000643 ATP binding site [chemical binding]; other site 717961000644 Q-loop/lid; other site 717961000645 ABC transporter signature motif; other site 717961000646 Walker B; other site 717961000647 D-loop; other site 717961000648 H-loop/switch region; other site 717961000649 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 717961000650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961000651 dimer interface [polypeptide binding]; other site 717961000652 conserved gate region; other site 717961000653 putative PBP binding loops; other site 717961000654 ABC-ATPase subunit interface; other site 717961000655 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 717961000656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961000657 dimer interface [polypeptide binding]; other site 717961000658 conserved gate region; other site 717961000659 putative PBP binding loops; other site 717961000660 ABC-ATPase subunit interface; other site 717961000661 PBP superfamily domain; Region: PBP_like_2; cl17296 717961000662 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 717961000663 Domain of unknown function (DUF377); Region: DUF377; pfam04041 717961000664 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 717961000665 active site 717961000666 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 717961000667 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 717961000668 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 717961000669 G1 box; other site 717961000670 GTP/Mg2+ binding site [chemical binding]; other site 717961000671 Switch I region; other site 717961000672 G2 box; other site 717961000673 G3 box; other site 717961000674 Switch II region; other site 717961000675 G4 box; other site 717961000676 G5 box; other site 717961000677 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 717961000678 Nucleoside recognition; Region: Gate; pfam07670 717961000679 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 717961000680 Nucleoside recognition; Region: Gate; pfam07670 717961000681 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 717961000682 Na binding site [ion binding]; other site 717961000683 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 717961000684 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 717961000685 putative catalytic cysteine [active] 717961000686 gamma-glutamyl kinase; Provisional; Region: PRK05429 717961000687 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 717961000688 nucleotide binding site [chemical binding]; other site 717961000689 homotetrameric interface [polypeptide binding]; other site 717961000690 putative phosphate binding site [ion binding]; other site 717961000691 putative allosteric binding site; other site 717961000692 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 717961000693 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717961000694 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717961000695 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 717961000696 putative lipid kinase; Reviewed; Region: PRK13337 717961000697 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 717961000698 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717961000699 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 717961000700 NodB motif; other site 717961000701 active site 717961000702 catalytic site [active] 717961000703 metal binding site [ion binding]; metal-binding site 717961000704 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 717961000705 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717961000706 HSP70 interaction site [polypeptide binding]; other site 717961000707 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 717961000708 Zn binding sites [ion binding]; other site 717961000709 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 717961000710 dimer interface [polypeptide binding]; other site 717961000711 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 717961000712 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 717961000713 nucleotide binding site [chemical binding]; other site 717961000714 NEF interaction site [polypeptide binding]; other site 717961000715 SBD interface [polypeptide binding]; other site 717961000716 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 717961000717 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 717961000718 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 717961000719 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 717961000720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961000721 motif II; other site 717961000722 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 717961000723 Part of AAA domain; Region: AAA_19; pfam13245 717961000724 Family description; Region: UvrD_C_2; pfam13538 717961000725 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 717961000726 SPFH domain / Band 7 family; Region: Band_7; pfam01145 717961000727 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 717961000728 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 717961000729 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 717961000730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 717961000731 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 717961000732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 717961000733 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 717961000734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717961000735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961000736 homodimer interface [polypeptide binding]; other site 717961000737 catalytic residue [active] 717961000738 COPI associated protein; Region: COPI_assoc; pfam08507 717961000739 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 717961000740 putative active site [active] 717961000741 Response regulator receiver domain; Region: Response_reg; pfam00072 717961000742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961000743 active site 717961000744 phosphorylation site [posttranslational modification] 717961000745 intermolecular recognition site; other site 717961000746 dimerization interface [polypeptide binding]; other site 717961000747 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 717961000748 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 717961000749 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 717961000750 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 717961000751 PhoU domain; Region: PhoU; pfam01895 717961000752 PhoU domain; Region: PhoU; pfam01895 717961000753 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 717961000754 active site 717961000755 Zn binding site [ion binding]; other site 717961000756 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717961000757 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717961000758 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 717961000759 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 717961000760 Walker A/P-loop; other site 717961000761 ATP binding site [chemical binding]; other site 717961000762 Q-loop/lid; other site 717961000763 ABC transporter signature motif; other site 717961000764 Walker B; other site 717961000765 D-loop; other site 717961000766 H-loop/switch region; other site 717961000767 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 717961000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961000769 dimer interface [polypeptide binding]; other site 717961000770 conserved gate region; other site 717961000771 putative PBP binding loops; other site 717961000772 ABC-ATPase subunit interface; other site 717961000773 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 717961000774 ligand binding site [chemical binding]; other site 717961000775 dimerization interface [polypeptide binding]; other site 717961000776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 717961000777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961000778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961000779 metal binding site [ion binding]; metal-binding site 717961000780 active site 717961000781 I-site; other site 717961000782 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961000783 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961000784 metal binding site [ion binding]; metal-binding site 717961000785 active site 717961000786 I-site; other site 717961000787 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717961000788 Predicted transcriptional regulator [Transcription]; Region: COG2378 717961000789 HTH domain; Region: HTH_11; pfam08279 717961000790 WYL domain; Region: WYL; pfam13280 717961000791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717961000792 WHG domain; Region: WHG; pfam13305 717961000793 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 717961000794 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 717961000795 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 717961000796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 717961000797 homodimer interface [polypeptide binding]; other site 717961000798 substrate-cofactor binding pocket; other site 717961000799 catalytic residue [active] 717961000800 glycyl-tRNA synthetase; Provisional; Region: PRK04173 717961000801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717961000802 motif 1; other site 717961000803 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 717961000804 active site 717961000805 motif 2; other site 717961000806 motif 3; other site 717961000807 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 717961000808 anticodon binding site; other site 717961000809 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 717961000810 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 717961000811 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 717961000812 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 717961000813 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961000814 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 717961000815 Walker A/P-loop; other site 717961000816 ATP binding site [chemical binding]; other site 717961000817 Q-loop/lid; other site 717961000818 ABC transporter signature motif; other site 717961000819 Walker B; other site 717961000820 D-loop; other site 717961000821 H-loop/switch region; other site 717961000822 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961000823 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 717961000824 Walker A/P-loop; other site 717961000825 ATP binding site [chemical binding]; other site 717961000826 Q-loop/lid; other site 717961000827 ABC transporter signature motif; other site 717961000828 Walker B; other site 717961000829 D-loop; other site 717961000830 H-loop/switch region; other site 717961000831 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 717961000832 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 717961000833 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717961000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961000835 dimer interface [polypeptide binding]; other site 717961000836 conserved gate region; other site 717961000837 ABC-ATPase subunit interface; other site 717961000838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717961000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961000840 dimer interface [polypeptide binding]; other site 717961000841 conserved gate region; other site 717961000842 putative PBP binding loops; other site 717961000843 ABC-ATPase subunit interface; other site 717961000844 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 717961000845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 717961000846 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 717961000847 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 717961000848 active site 717961000849 metal binding site [ion binding]; metal-binding site 717961000850 DNA repair protein RadA; Provisional; Region: PRK11823 717961000851 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 717961000852 Walker A motif/ATP binding site; other site 717961000853 ATP binding site [chemical binding]; other site 717961000854 Walker B motif; other site 717961000855 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 717961000856 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 717961000857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961000858 S-adenosylmethionine binding site [chemical binding]; other site 717961000859 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717961000860 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717961000861 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 717961000862 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 717961000863 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 717961000864 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 717961000865 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717961000866 Walker A motif; other site 717961000867 ATP binding site [chemical binding]; other site 717961000868 Walker B motif; other site 717961000869 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 717961000870 DNA binding site [nucleotide binding] 717961000871 Bacterial transcriptional activator domain; Region: BTAD; smart01043 717961000872 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 717961000873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961000874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961000875 ABC transporter; Region: ABC_tran_2; pfam12848 717961000876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961000877 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 717961000878 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717961000879 active site 717961000880 HIGH motif; other site 717961000881 nucleotide binding site [chemical binding]; other site 717961000882 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 717961000883 active site 717961000884 KMSKS motif; other site 717961000885 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 717961000886 tRNA binding surface [nucleotide binding]; other site 717961000887 anticodon binding site; other site 717961000888 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 717961000889 EamA-like transporter family; Region: EamA; pfam00892 717961000890 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 717961000891 tartrate dehydrogenase; Region: TTC; TIGR02089 717961000892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961000893 Coenzyme A binding pocket [chemical binding]; other site 717961000894 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 717961000895 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 717961000896 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 717961000897 substrate binding site [chemical binding]; other site 717961000898 ligand binding site [chemical binding]; other site 717961000899 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 717961000900 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 717961000901 putative valine binding site [chemical binding]; other site 717961000902 dimer interface [polypeptide binding]; other site 717961000903 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 717961000904 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 717961000905 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 717961000906 PYR/PP interface [polypeptide binding]; other site 717961000907 dimer interface [polypeptide binding]; other site 717961000908 TPP binding site [chemical binding]; other site 717961000909 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717961000910 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 717961000911 TPP-binding site [chemical binding]; other site 717961000912 dimer interface [polypeptide binding]; other site 717961000913 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 717961000914 Stage II sporulation protein; Region: SpoIID; pfam08486 717961000915 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 717961000916 active site 717961000917 catalytic site [active] 717961000918 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 717961000919 active site 717961000920 catalytic site [active] 717961000921 Competence-damaged protein; Region: CinA; pfam02464 717961000922 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 717961000923 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 717961000924 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 717961000925 Ligand Binding Site [chemical binding]; other site 717961000926 germination protein YpeB; Region: spore_YpeB; TIGR02889 717961000927 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 717961000928 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 717961000929 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 717961000930 Walker A/P-loop; other site 717961000931 ATP binding site [chemical binding]; other site 717961000932 Q-loop/lid; other site 717961000933 ABC transporter signature motif; other site 717961000934 Walker B; other site 717961000935 D-loop; other site 717961000936 H-loop/switch region; other site 717961000937 TOBE domain; Region: TOBE_2; pfam08402 717961000938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717961000939 active site 717961000940 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 717961000941 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 717961000942 Glycoprotease family; Region: Peptidase_M22; pfam00814 717961000943 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 717961000944 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 717961000945 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 717961000946 Potassium binding sites [ion binding]; other site 717961000947 Cesium cation binding sites [ion binding]; other site 717961000948 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 717961000949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961000950 Mg2+ binding site [ion binding]; other site 717961000951 G-X-G motif; other site 717961000952 DNA gyrase B; Region: DNA_gyraseB; pfam00204 717961000953 ATP binding site [chemical binding]; other site 717961000954 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 717961000955 active site 717961000956 putative metal-binding site [ion binding]; other site 717961000957 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 717961000958 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 717961000959 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 717961000960 hexamer (dimer of trimers) interface [polypeptide binding]; other site 717961000961 substrate binding site [chemical binding]; other site 717961000962 trimer interface [polypeptide binding]; other site 717961000963 Mn binding site [ion binding]; other site 717961000964 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 717961000965 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 717961000966 putative catalytic cysteine [active] 717961000967 YhhN-like protein; Region: YhhN; pfam07947 717961000968 CBD_II domain; Region: CBD_II; smart00637 717961000969 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961000970 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 717961000971 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 717961000972 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961000973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961000974 non-specific DNA binding site [nucleotide binding]; other site 717961000975 salt bridge; other site 717961000976 sequence-specific DNA binding site [nucleotide binding]; other site 717961000977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 717961000978 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 717961000979 DNA binding residues [nucleotide binding] 717961000980 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961000981 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 717961000982 catalytic residues [active] 717961000983 catalytic nucleophile [active] 717961000984 Recombinase; Region: Recombinase; pfam07508 717961000985 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961000986 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 717961000987 active site 717961000988 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 717961000989 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 717961000990 Phage tail protein; Region: Sipho_tail; pfam05709 717961000991 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 717961000992 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 717961000993 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 717961000994 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717961000995 oligomerization interface [polypeptide binding]; other site 717961000996 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 717961000997 Phage capsid family; Region: Phage_capsid; pfam05065 717961000998 Phage portal protein; Region: Phage_portal; pfam04860 717961000999 Phage-related protein [Function unknown]; Region: COG4695 717961001000 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 717961001001 AAA domain; Region: AAA_17; pfam13207 717961001002 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 717961001003 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 717961001004 putative active site pocket [active] 717961001005 dimerization interface [polypeptide binding]; other site 717961001006 putative catalytic residue [active] 717961001007 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 717961001008 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 717961001009 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717961001010 ParB-like nuclease domain; Region: ParBc; pfam02195 717961001011 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717961001012 DNA methylase; Region: N6_N4_Mtase; pfam01555 717961001013 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 717961001014 Phage terminase, small subunit; Region: Terminase_4; cl01525 717961001015 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 717961001016 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 717961001017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961001018 ATP binding site [chemical binding]; other site 717961001019 putative Mg++ binding site [ion binding]; other site 717961001020 nucleotide binding region [chemical binding]; other site 717961001021 helicase superfamily c-terminal domain; Region: HELICc; smart00490 717961001022 ATP-binding site [chemical binding]; other site 717961001023 VRR-NUC domain; Region: VRR_NUC; pfam08774 717961001024 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 717961001025 D5 N terminal like; Region: D5_N; pfam08706 717961001026 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 717961001027 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 717961001028 active site 717961001029 DNA binding site [nucleotide binding] 717961001030 catalytic site [active] 717961001031 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 717961001032 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 717961001033 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 717961001034 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 717961001035 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 717961001036 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 717961001037 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 717961001038 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 717961001039 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 717961001040 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 717961001041 HsdM N-terminal domain; Region: HsdM_N; pfam12161 717961001042 Methyltransferase domain; Region: Methyltransf_26; pfam13659 717961001043 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 717961001044 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 717961001045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961001046 ATP binding site [chemical binding]; other site 717961001047 putative Mg++ binding site [ion binding]; other site 717961001048 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 717961001049 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 717961001050 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961001051 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961001052 Walker A/P-loop; other site 717961001053 ATP binding site [chemical binding]; other site 717961001054 Q-loop/lid; other site 717961001055 ABC transporter signature motif; other site 717961001056 Walker B; other site 717961001057 D-loop; other site 717961001058 H-loop/switch region; other site 717961001059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717961001060 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 717961001061 Double zinc ribbon; Region: DZR; pfam12773 717961001062 Tic20-like protein; Region: Tic20; pfam09685 717961001063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717961001064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717961001065 active site 717961001066 catalytic tetrad [active] 717961001067 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 717961001068 putative ADP-ribose binding site [chemical binding]; other site 717961001069 putative active site [active] 717961001070 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717961001071 metal ion-dependent adhesion site (MIDAS); other site 717961001072 Fic family protein [Function unknown]; Region: COG3177 717961001073 Fic/DOC family; Region: Fic; pfam02661 717961001074 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 717961001075 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 717961001076 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 717961001077 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 717961001078 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 717961001079 putative substrate binding site [chemical binding]; other site 717961001080 putative ATP binding site [chemical binding]; other site 717961001081 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 717961001082 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 717961001083 active site 717961001084 phosphorylation site [posttranslational modification] 717961001085 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 717961001086 active site 717961001087 P-loop; other site 717961001088 phosphorylation site [posttranslational modification] 717961001089 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 717961001090 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 717961001091 dimerization domain swap beta strand [polypeptide binding]; other site 717961001092 regulatory protein interface [polypeptide binding]; other site 717961001093 active site 717961001094 regulatory phosphorylation site [posttranslational modification]; other site 717961001095 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 717961001096 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 717961001097 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 717961001098 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 717961001099 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 717961001100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717961001101 Soluble P-type ATPase [General function prediction only]; Region: COG4087 717961001102 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 717961001103 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 717961001104 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717961001105 Peptidase family M23; Region: Peptidase_M23; pfam01551 717961001106 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 717961001107 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 717961001108 gamma subunit interface [polypeptide binding]; other site 717961001109 epsilon subunit interface [polypeptide binding]; other site 717961001110 LBP interface [polypeptide binding]; other site 717961001111 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 717961001112 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717961001113 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 717961001114 alpha subunit interaction interface [polypeptide binding]; other site 717961001115 Walker A motif; other site 717961001116 ATP binding site [chemical binding]; other site 717961001117 Walker B motif; other site 717961001118 inhibitor binding site; inhibition site 717961001119 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717961001120 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 717961001121 core domain interface [polypeptide binding]; other site 717961001122 delta subunit interface [polypeptide binding]; other site 717961001123 epsilon subunit interface [polypeptide binding]; other site 717961001124 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 717961001125 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717961001126 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 717961001127 beta subunit interaction interface [polypeptide binding]; other site 717961001128 Walker A motif; other site 717961001129 ATP binding site [chemical binding]; other site 717961001130 Walker B motif; other site 717961001131 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717961001132 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 717961001133 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 717961001134 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 717961001135 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 717961001136 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 717961001137 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 717961001138 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 717961001139 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 717961001140 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717961001141 minor groove reading motif; other site 717961001142 helix-hairpin-helix signature motif; other site 717961001143 active site 717961001144 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 717961001145 ligand binding site [chemical binding]; other site 717961001146 active site 717961001147 UGI interface [polypeptide binding]; other site 717961001148 catalytic site [active] 717961001149 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 717961001150 alpha-galactosidase; Region: PLN02808; cl17638 717961001151 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961001152 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 717961001153 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 717961001154 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 717961001155 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 717961001156 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001157 Interdomain contacts; other site 717961001158 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001159 Interdomain contacts; other site 717961001160 Cytokine receptor motif; other site 717961001161 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001162 Interdomain contacts; other site 717961001163 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961001164 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001165 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001166 Interdomain contacts; other site 717961001167 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001168 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001169 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001170 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001171 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 717961001172 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 717961001173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 717961001174 nucleotide binding region [chemical binding]; other site 717961001175 ATP-binding site [chemical binding]; other site 717961001176 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 717961001177 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717961001178 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 717961001179 GTP/Mg2+ binding site [chemical binding]; other site 717961001180 G5 box; other site 717961001181 trmE is a tRNA modification GTPase; Region: trmE; cd04164 717961001182 G1 box; other site 717961001183 G1 box; other site 717961001184 GTP/Mg2+ binding site [chemical binding]; other site 717961001185 Switch I region; other site 717961001186 Switch I region; other site 717961001187 G2 box; other site 717961001188 G2 box; other site 717961001189 Switch II region; other site 717961001190 G3 box; other site 717961001191 G4 box; other site 717961001192 G5 box; other site 717961001193 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 717961001194 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 717961001195 Na2 binding site [ion binding]; other site 717961001196 putative substrate binding site 1 [chemical binding]; other site 717961001197 Na binding site 1 [ion binding]; other site 717961001198 putative substrate binding site 2 [chemical binding]; other site 717961001199 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 717961001200 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 717961001201 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717961001202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961001203 FeS/SAM binding site; other site 717961001204 recombination regulator RecX; Reviewed; Region: recX; PRK00117 717961001205 recombinase A; Provisional; Region: recA; PRK09354 717961001206 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 717961001207 hexamer interface [polypeptide binding]; other site 717961001208 Walker A motif; other site 717961001209 ATP binding site [chemical binding]; other site 717961001210 Walker B motif; other site 717961001211 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 717961001212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717961001213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961001214 active site 717961001215 phosphorylation site [posttranslational modification] 717961001216 intermolecular recognition site; other site 717961001217 dimerization interface [polypeptide binding]; other site 717961001218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717961001219 DNA binding site [nucleotide binding] 717961001220 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 717961001221 dimer interface [polypeptide binding]; other site 717961001222 Citrate synthase; Region: Citrate_synt; pfam00285 717961001223 active site 717961001224 citrylCoA binding site [chemical binding]; other site 717961001225 oxalacetate/citrate binding site [chemical binding]; other site 717961001226 coenzyme A binding site [chemical binding]; other site 717961001227 catalytic triad [active] 717961001228 stage II sporulation protein D; Region: spore_II_D; TIGR02870 717961001229 Putative zinc-finger; Region: zf-HC2; pfam13490 717961001230 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 717961001231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961001232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961001233 DNA binding residues [nucleotide binding] 717961001234 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961001235 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 717961001236 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 717961001237 Predicted transcriptional regulator [Transcription]; Region: COG2378 717961001238 WYL domain; Region: WYL; pfam13280 717961001239 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 717961001240 Melibiase; Region: Melibiase; pfam02065 717961001241 Domain of unknown function DUF20; Region: UPF0118; pfam01594 717961001242 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717961001243 putative carbohydrate kinase; Provisional; Region: PRK10565 717961001244 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 717961001245 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 717961001246 putative substrate binding site [chemical binding]; other site 717961001247 putative ATP binding site [chemical binding]; other site 717961001248 CHAP domain; Region: CHAP; pfam05257 717961001249 Bacterial SH3 domain; Region: SH3_3; pfam08239 717961001250 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001251 Interdomain contacts; other site 717961001252 Cytokine receptor motif; other site 717961001253 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001254 Interdomain contacts; other site 717961001255 Cytokine receptor motif; other site 717961001256 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001257 Interdomain contacts; other site 717961001258 Cytokine receptor motif; other site 717961001259 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 717961001260 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 717961001261 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 717961001262 dimer interface [polypeptide binding]; other site 717961001263 motif 1; other site 717961001264 active site 717961001265 motif 2; other site 717961001266 motif 3; other site 717961001267 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 717961001268 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 717961001269 putative tRNA-binding site [nucleotide binding]; other site 717961001270 B3/4 domain; Region: B3_4; pfam03483 717961001271 tRNA synthetase B5 domain; Region: B5; smart00874 717961001272 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 717961001273 dimer interface [polypeptide binding]; other site 717961001274 motif 1; other site 717961001275 motif 3; other site 717961001276 motif 2; other site 717961001277 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 717961001278 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 717961001279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961001280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961001281 Walker A/P-loop; other site 717961001282 Walker A/P-loop; other site 717961001283 ATP binding site [chemical binding]; other site 717961001284 ATP binding site [chemical binding]; other site 717961001285 Q-loop/lid; other site 717961001286 ABC transporter signature motif; other site 717961001287 Walker B; other site 717961001288 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961001289 D-loop; other site 717961001290 H-loop/switch region; other site 717961001291 ABC transporter; Region: ABC_tran_2; pfam12848 717961001292 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961001293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961001294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961001295 Walker A/P-loop; other site 717961001296 ATP binding site [chemical binding]; other site 717961001297 Q-loop/lid; other site 717961001298 ABC transporter signature motif; other site 717961001299 Walker B; other site 717961001300 D-loop; other site 717961001301 H-loop/switch region; other site 717961001302 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961001303 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961001304 Walker A/P-loop; other site 717961001305 ATP binding site [chemical binding]; other site 717961001306 Q-loop/lid; other site 717961001307 ABC transporter signature motif; other site 717961001308 Walker B; other site 717961001309 D-loop; other site 717961001310 H-loop/switch region; other site 717961001311 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 717961001312 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717961001313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961001314 dimer interface [polypeptide binding]; other site 717961001315 conserved gate region; other site 717961001316 putative PBP binding loops; other site 717961001317 ABC-ATPase subunit interface; other site 717961001318 Tetratricopeptide repeat; Region: TPR_16; pfam13432 717961001319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717961001320 TPR motif; other site 717961001321 Yip1 domain; Region: Yip1; pfam04893 717961001322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961001323 dimer interface [polypeptide binding]; other site 717961001324 conserved gate region; other site 717961001325 ABC-ATPase subunit interface; other site 717961001326 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 717961001327 nudix motif; other site 717961001328 DinB superfamily; Region: DinB_2; pfam12867 717961001329 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 717961001330 Amidohydrolase; Region: Amidohydro_2; pfam04909 717961001331 active site 717961001332 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 717961001333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961001334 FeS/SAM binding site; other site 717961001335 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 717961001336 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 717961001337 Predicted methyltransferases [General function prediction only]; Region: COG0313 717961001338 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 717961001339 putative SAM binding site [chemical binding]; other site 717961001340 putative homodimer interface [polypeptide binding]; other site 717961001341 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 717961001342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961001343 S-adenosylmethionine binding site [chemical binding]; other site 717961001344 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 717961001345 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 717961001346 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 717961001347 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 717961001348 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 717961001349 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 717961001350 active site 717961001351 homodimer interface [polypeptide binding]; other site 717961001352 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 717961001353 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 717961001354 nudix motif; other site 717961001355 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 717961001356 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 717961001357 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 717961001358 putative active site [active] 717961001359 flavoprotein, HI0933 family; Region: TIGR00275 717961001360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961001361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961001362 Walker A/P-loop; other site 717961001363 ATP binding site [chemical binding]; other site 717961001364 Q-loop/lid; other site 717961001365 ABC transporter signature motif; other site 717961001366 Walker B; other site 717961001367 D-loop; other site 717961001368 H-loop/switch region; other site 717961001369 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961001370 FtsX-like permease family; Region: FtsX; pfam02687 717961001371 FtsX-like permease family; Region: FtsX; pfam02687 717961001372 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 717961001373 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717961001374 active site 717961001375 ATP binding site [chemical binding]; other site 717961001376 substrate binding site [chemical binding]; other site 717961001377 activation loop (A-loop); other site 717961001378 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 717961001379 PASTA domain; Region: PASTA; smart00740 717961001380 Chorismate mutase type II; Region: CM_2; smart00830 717961001381 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 717961001382 Prephenate dehydratase; Region: PDT; pfam00800 717961001383 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 717961001384 putative L-Phe binding site [chemical binding]; other site 717961001385 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 717961001386 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 717961001387 substrate binding site; other site 717961001388 dimer interface; other site 717961001389 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 717961001390 homotrimer interaction site [polypeptide binding]; other site 717961001391 zinc binding site [ion binding]; other site 717961001392 CDP-binding sites; other site 717961001393 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 717961001394 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 717961001395 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 717961001396 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 717961001397 homodimer interface [polypeptide binding]; other site 717961001398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961001399 catalytic residue [active] 717961001400 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 717961001401 spermidine synthase; Provisional; Region: PRK00811 717961001402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961001403 S-adenosylmethionine binding site [chemical binding]; other site 717961001404 CAAX protease self-immunity; Region: Abi; pfam02517 717961001405 CAAX protease self-immunity; Region: Abi; pfam02517 717961001406 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 717961001407 active site 717961001408 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 717961001409 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 717961001410 putative catalytic cysteine [active] 717961001411 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 717961001412 putative active site [active] 717961001413 metal binding site [ion binding]; metal-binding site 717961001414 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 717961001415 WYL domain; Region: WYL; pfam13280 717961001416 WYL domain; Region: WYL; pfam13280 717961001417 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 717961001418 cheY-homologous receiver domain; Region: REC; smart00448 717961001419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961001420 active site 717961001421 phosphorylation site [posttranslational modification] 717961001422 intermolecular recognition site; other site 717961001423 dimerization interface [polypeptide binding]; other site 717961001424 LytTr DNA-binding domain; Region: LytTR; pfam04397 717961001425 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 717961001426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 717961001427 ATP binding site [chemical binding]; other site 717961001428 Mg2+ binding site [ion binding]; other site 717961001429 G-X-G motif; other site 717961001430 Predicted permeases [General function prediction only]; Region: COG0679 717961001431 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 717961001432 substrate binding site [chemical binding]; other site 717961001433 multimerization interface [polypeptide binding]; other site 717961001434 ATP binding site [chemical binding]; other site 717961001435 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 717961001436 CoenzymeA binding site [chemical binding]; other site 717961001437 subunit interaction site [polypeptide binding]; other site 717961001438 PHB binding site; other site 717961001439 TM2 domain; Region: TM2; cl00984 717961001440 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 717961001441 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 717961001442 CotJB protein; Region: CotJB; pfam12652 717961001443 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 717961001444 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 717961001445 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 717961001446 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 717961001447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961001448 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961001449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717961001450 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961001451 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961001452 Walker A/P-loop; other site 717961001453 ATP binding site [chemical binding]; other site 717961001454 Q-loop/lid; other site 717961001455 ABC transporter signature motif; other site 717961001456 Walker B; other site 717961001457 D-loop; other site 717961001458 H-loop/switch region; other site 717961001459 FtsX-like permease family; Region: FtsX; pfam02687 717961001460 FtsX-like permease family; Region: FtsX; pfam02687 717961001461 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961001462 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961001463 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717961001464 Walker A/P-loop; other site 717961001465 ATP binding site [chemical binding]; other site 717961001466 Q-loop/lid; other site 717961001467 ABC transporter signature motif; other site 717961001468 Walker B; other site 717961001469 D-loop; other site 717961001470 H-loop/switch region; other site 717961001471 Predicted transcriptional regulators [Transcription]; Region: COG1725 717961001472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717961001473 DNA-binding site [nucleotide binding]; DNA binding site 717961001474 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 717961001475 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 717961001476 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 717961001477 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 717961001478 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 717961001479 GatB domain; Region: GatB_Yqey; smart00845 717961001480 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 717961001481 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 717961001482 dimer interface [polypeptide binding]; other site 717961001483 anticodon binding site; other site 717961001484 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 717961001485 homodimer interface [polypeptide binding]; other site 717961001486 motif 1; other site 717961001487 active site 717961001488 motif 2; other site 717961001489 GAD domain; Region: GAD; pfam02938 717961001490 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717961001491 active site 717961001492 motif 3; other site 717961001493 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 717961001494 Family of unknown function (DUF633); Region: DUF633; pfam04816 717961001495 Uncharacterized conserved protein [Function unknown]; Region: COG0327 717961001496 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 717961001497 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 717961001498 Domain of unknown function (DUF814); Region: DUF814; pfam05670 717961001499 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 717961001500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717961001501 active site 717961001502 HIGH motif; other site 717961001503 nucleotide binding site [chemical binding]; other site 717961001504 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 717961001505 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 717961001506 active site 717961001507 KMSKS motif; other site 717961001508 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 717961001509 tRNA binding surface [nucleotide binding]; other site 717961001510 anticodon binding site; other site 717961001511 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 717961001512 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 717961001513 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 717961001514 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 717961001515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 717961001516 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 717961001517 active site 717961001518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961001519 metal binding site [ion binding]; metal-binding site 717961001520 active site 717961001521 I-site; other site 717961001522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717961001523 Transcriptional regulator; Region: Rrf2; cl17282 717961001524 Rrf2 family protein; Region: rrf2_super; TIGR00738 717961001525 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 717961001526 putative active site [active] 717961001527 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 717961001528 flagellin; Provisional; Region: PRK12806 717961001529 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 717961001530 Flagellin N-methylase; Region: FliB; pfam03692 717961001531 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 717961001532 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 717961001533 putative active site [active] 717961001534 metal binding site [ion binding]; metal-binding site 717961001535 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 717961001536 ANTAR domain; Region: ANTAR; pfam03861 717961001537 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 717961001538 domain_subunit interface; other site 717961001539 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 717961001540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717961001541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717961001542 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 717961001543 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 717961001544 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 717961001545 putative active site [active] 717961001546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 717961001547 Zeta toxin; Region: Zeta_toxin; pfam06414 717961001548 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 717961001549 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 717961001550 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717961001551 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 717961001552 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 717961001553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961001554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717961001555 dimer interface [polypeptide binding]; other site 717961001556 phosphorylation site [posttranslational modification] 717961001557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961001558 ATP binding site [chemical binding]; other site 717961001559 Mg2+ binding site [ion binding]; other site 717961001560 G-X-G motif; other site 717961001561 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 717961001562 putative active site [active] 717961001563 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 717961001564 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 717961001565 HIGH motif; other site 717961001566 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 717961001567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717961001568 active site 717961001569 KMSKS motif; other site 717961001570 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 717961001571 tRNA binding surface [nucleotide binding]; other site 717961001572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 717961001573 active site 717961001574 phosphorylation site [posttranslational modification] 717961001575 intermolecular recognition site; other site 717961001576 dimerization interface [polypeptide binding]; other site 717961001577 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001578 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001579 Interdomain contacts; other site 717961001580 Cytokine receptor motif; other site 717961001581 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001582 Interdomain contacts; other site 717961001583 Cytokine receptor motif; other site 717961001584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001585 Interdomain contacts; other site 717961001586 Cytokine receptor motif; other site 717961001587 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961001588 Interdomain contacts; other site 717961001589 Cytokine receptor motif; other site 717961001590 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 717961001591 Rubredoxin; Region: Rubredoxin; pfam00301 717961001592 iron binding site [ion binding]; other site 717961001593 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 717961001594 Rubrerythrin [Energy production and conversion]; Region: COG1592 717961001595 diiron binding motif [ion binding]; other site 717961001596 Clostripain family; Region: Peptidase_C11; pfam03415 717961001597 Uncharacterized conserved protein [Function unknown]; Region: COG1434 717961001598 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 717961001599 putative active site [active] 717961001600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961001601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961001602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961001603 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 717961001604 propionate/acetate kinase; Provisional; Region: PRK12379 717961001605 AAA domain; Region: AAA_14; pfam13173 717961001606 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 717961001607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961001608 Coenzyme A binding pocket [chemical binding]; other site 717961001609 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 717961001610 Coenzyme A binding pocket [chemical binding]; other site 717961001611 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 717961001612 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 717961001613 DNA binding residues [nucleotide binding] 717961001614 dimer interface [polypeptide binding]; other site 717961001615 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 717961001616 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 717961001617 TfoX N-terminal domain; Region: TfoX_N; cl17592 717961001618 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 717961001619 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717961001620 Peptidase family M23; Region: Peptidase_M23; pfam01551 717961001621 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 717961001622 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 717961001623 putative active site; other site 717961001624 catalytic triad [active] 717961001625 putative dimer interface [polypeptide binding]; other site 717961001626 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 717961001627 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 717961001628 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 717961001629 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 717961001630 dimer interface [polypeptide binding]; other site 717961001631 PYR/PP interface [polypeptide binding]; other site 717961001632 TPP binding site [chemical binding]; other site 717961001633 substrate binding site [chemical binding]; other site 717961001634 Transcriptional regulator; Region: Transcrip_reg; cl00361 717961001635 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 717961001636 TPP-binding site; other site 717961001637 4Fe-4S binding domain; Region: Fer4; pfam00037 717961001638 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 717961001639 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 717961001640 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 717961001641 Part of AAA domain; Region: AAA_19; pfam13245 717961001642 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 717961001643 Abi-like protein; Region: Abi_2; pfam07751 717961001644 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 717961001645 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 717961001646 active site 717961001647 tetramer interface; other site 717961001648 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 717961001649 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 717961001650 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 717961001651 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 717961001652 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 717961001653 DNA binding site [nucleotide binding] 717961001654 active site 717961001655 A new structural DNA glycosylase; Region: AlkD_like; cd06561 717961001656 active site 717961001657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961001658 Response regulator receiver domain; Region: Response_reg; pfam00072 717961001659 active site 717961001660 phosphorylation site [posttranslational modification] 717961001661 intermolecular recognition site; other site 717961001662 dimerization interface [polypeptide binding]; other site 717961001663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961001664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961001665 ATP binding site [chemical binding]; other site 717961001666 Mg2+ binding site [ion binding]; other site 717961001667 G-X-G motif; other site 717961001668 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 717961001669 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 717961001670 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717961001671 protein binding site [polypeptide binding]; other site 717961001672 Predicted membrane protein [Function unknown]; Region: COG2855 717961001673 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 717961001674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717961001675 putative acyl-acceptor binding pocket; other site 717961001676 cytidylate kinase; Provisional; Region: cmk; PRK00023 717961001677 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 717961001678 CMP-binding site; other site 717961001679 The sites determining sugar specificity; other site 717961001680 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717961001681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717961001682 active site 717961001683 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 717961001684 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 717961001685 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 717961001686 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 717961001687 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 717961001688 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 717961001689 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 717961001690 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 717961001691 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 717961001692 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 717961001693 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 717961001694 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 717961001695 Walker A motif; other site 717961001696 ATP binding site [chemical binding]; other site 717961001697 Walker B motif; other site 717961001698 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 717961001699 putative active site [active] 717961001700 dimerization interface [polypeptide binding]; other site 717961001701 putative tRNAtyr binding site [nucleotide binding]; other site 717961001702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 717961001703 Phosphotransferase enzyme family; Region: APH; pfam01636 717961001704 active site 717961001705 substrate binding site [chemical binding]; other site 717961001706 ATP binding site [chemical binding]; other site 717961001707 Transglycosylase; Region: Transgly; pfam00912 717961001708 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 717961001709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 717961001710 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 717961001711 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 717961001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961001713 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 717961001714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717961001715 putative active site [active] 717961001716 heme pocket [chemical binding]; other site 717961001717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961001718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961001719 metal binding site [ion binding]; metal-binding site 717961001720 active site 717961001721 I-site; other site 717961001722 transcription termination factor NusA; Region: NusA; TIGR01953 717961001723 NusA N-terminal domain; Region: NusA_N; pfam08529 717961001724 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 717961001725 RNA binding site [nucleotide binding]; other site 717961001726 homodimer interface [polypeptide binding]; other site 717961001727 NusA-like KH domain; Region: KH_5; pfam13184 717961001728 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 717961001729 G-X-X-G motif; other site 717961001730 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 717961001731 putative RNA binding cleft [nucleotide binding]; other site 717961001732 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 717961001733 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 717961001734 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 717961001735 DHH family; Region: DHH; pfam01368 717961001736 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 717961001737 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 717961001738 RNA binding site [nucleotide binding]; other site 717961001739 active site 717961001740 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 717961001741 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717961001742 Walker A/P-loop; other site 717961001743 ATP binding site [chemical binding]; other site 717961001744 Q-loop/lid; other site 717961001745 ABC transporter signature motif; other site 717961001746 Walker B; other site 717961001747 D-loop; other site 717961001748 H-loop/switch region; other site 717961001749 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 717961001750 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 717961001751 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 717961001752 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 717961001753 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 717961001754 aspartate ammonia-lyase; Provisional; Region: PRK13353 717961001755 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 717961001756 Tic20-like protein; Region: Tic20; pfam09685 717961001757 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 717961001758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717961001759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961001760 homodimer interface [polypeptide binding]; other site 717961001761 catalytic residue [active] 717961001762 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 717961001763 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961001764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961001765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961001766 Walker A/P-loop; other site 717961001767 ATP binding site [chemical binding]; other site 717961001768 Q-loop/lid; other site 717961001769 ABC transporter signature motif; other site 717961001770 Walker B; other site 717961001771 D-loop; other site 717961001772 H-loop/switch region; other site 717961001773 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 717961001774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961001775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961001776 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 717961001777 Walker A/P-loop; other site 717961001778 ATP binding site [chemical binding]; other site 717961001779 Q-loop/lid; other site 717961001780 ABC transporter signature motif; other site 717961001781 Walker B; other site 717961001782 D-loop; other site 717961001783 H-loop/switch region; other site 717961001784 aspartate kinase; Reviewed; Region: PRK09034 717961001785 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 717961001786 nucleotide binding site [chemical binding]; other site 717961001787 substrate binding site [chemical binding]; other site 717961001788 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 717961001789 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 717961001790 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 717961001791 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 717961001792 dimerization interface [polypeptide binding]; other site 717961001793 active site 717961001794 Domain of unknown function (DUF303); Region: DUF303; pfam03629 717961001795 4-alpha-glucanotransferase; Provisional; Region: PRK14508 717961001796 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 717961001797 putative active site [active] 717961001798 catalytic residue [active] 717961001799 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 717961001800 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 717961001801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961001802 ATP binding site [chemical binding]; other site 717961001803 putative Mg++ binding site [ion binding]; other site 717961001804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717961001805 nucleotide binding region [chemical binding]; other site 717961001806 ATP-binding site [chemical binding]; other site 717961001807 TRCF domain; Region: TRCF; pfam03461 717961001808 shikimate kinase; Reviewed; Region: aroK; PRK00131 717961001809 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 717961001810 ADP binding site [chemical binding]; other site 717961001811 magnesium binding site [ion binding]; other site 717961001812 putative shikimate binding site; other site 717961001813 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 717961001814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717961001815 UDP-galactopyranose mutase; Region: GLF; pfam03275 717961001816 pyruvate phosphate dikinase; Provisional; Region: PRK09279 717961001817 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 717961001818 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 717961001819 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 717961001820 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717961001821 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 717961001822 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 717961001823 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 717961001824 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 717961001825 active site 717961001826 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 717961001827 Response regulator receiver domain; Region: Response_reg; pfam00072 717961001828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961001829 active site 717961001830 phosphorylation site [posttranslational modification] 717961001831 intermolecular recognition site; other site 717961001832 dimerization interface [polypeptide binding]; other site 717961001833 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 717961001834 TrkA-N domain; Region: TrkA_N; pfam02254 717961001835 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 717961001836 TrkA-N domain; Region: TrkA_N; pfam02254 717961001837 TrkA-C domain; Region: TrkA_C; pfam02080 717961001838 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 717961001839 homodimer interface [polypeptide binding]; other site 717961001840 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 717961001841 active site pocket [active] 717961001842 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 717961001843 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 717961001844 active site 717961001845 homodimer interface [polypeptide binding]; other site 717961001846 catalytic site [active] 717961001847 DNA polymerase IV; Reviewed; Region: PRK03103 717961001848 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 717961001849 active site 717961001850 DNA binding site [nucleotide binding] 717961001851 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717961001852 homotrimer interaction site [polypeptide binding]; other site 717961001853 putative active site [active] 717961001854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961001855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961001856 non-specific DNA binding site [nucleotide binding]; other site 717961001857 salt bridge; other site 717961001858 sequence-specific DNA binding site [nucleotide binding]; other site 717961001859 Domain of unknown function (DUF955); Region: DUF955; pfam06114 717961001860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 717961001861 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 717961001862 DNA polymerase I; Provisional; Region: PRK05755 717961001863 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 717961001864 active site 717961001865 metal binding site 1 [ion binding]; metal-binding site 717961001866 putative 5' ssDNA interaction site; other site 717961001867 metal binding site 3; metal-binding site 717961001868 metal binding site 2 [ion binding]; metal-binding site 717961001869 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 717961001870 putative DNA binding site [nucleotide binding]; other site 717961001871 putative metal binding site [ion binding]; other site 717961001872 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 717961001873 active site 717961001874 substrate binding site [chemical binding]; other site 717961001875 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 717961001876 active site 717961001877 DNA binding site [nucleotide binding] 717961001878 catalytic site [active] 717961001879 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 717961001880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961001881 Coenzyme A binding pocket [chemical binding]; other site 717961001882 phosphoglyceromutase; Provisional; Region: PRK05434 717961001883 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 717961001884 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 717961001885 triosephosphate isomerase; Provisional; Region: PRK14565 717961001886 substrate binding site [chemical binding]; other site 717961001887 dimer interface [polypeptide binding]; other site 717961001888 catalytic triad [active] 717961001889 Phosphoglycerate kinase; Region: PGK; pfam00162 717961001890 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 717961001891 substrate binding site [chemical binding]; other site 717961001892 hinge regions; other site 717961001893 ADP binding site [chemical binding]; other site 717961001894 catalytic site [active] 717961001895 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717961001896 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 717961001897 NodB motif; other site 717961001898 active site 717961001899 catalytic site [active] 717961001900 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 717961001901 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961001902 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 717961001903 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961001904 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 717961001905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717961001906 active site 717961001907 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 717961001908 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 717961001909 putative ligand binding site [chemical binding]; other site 717961001910 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 717961001911 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 717961001912 Walker A/P-loop; other site 717961001913 ATP binding site [chemical binding]; other site 717961001914 Q-loop/lid; other site 717961001915 ABC transporter signature motif; other site 717961001916 Walker B; other site 717961001917 D-loop; other site 717961001918 H-loop/switch region; other site 717961001919 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 717961001920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717961001921 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 717961001922 TM-ABC transporter signature motif; other site 717961001923 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717961001924 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 717961001925 TM-ABC transporter signature motif; other site 717961001926 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 717961001927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961001928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961001929 DNA binding residues [nucleotide binding] 717961001930 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 717961001931 23S rRNA interface [nucleotide binding]; other site 717961001932 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 717961001933 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 717961001934 core dimer interface [polypeptide binding]; other site 717961001935 peripheral dimer interface [polypeptide binding]; other site 717961001936 L10 interface [polypeptide binding]; other site 717961001937 L11 interface [polypeptide binding]; other site 717961001938 putative EF-Tu interaction site [polypeptide binding]; other site 717961001939 putative EF-G interaction site [polypeptide binding]; other site 717961001940 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 717961001941 metal binding sites [ion binding]; metal-binding site 717961001942 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 717961001943 nudix motif; other site 717961001944 C2 domain; Region: C2; cl14603 717961001945 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 717961001946 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 717961001947 dimerization interface [polypeptide binding]; other site 717961001948 active site 717961001949 L-aspartate oxidase; Provisional; Region: PRK06175 717961001950 L-aspartate oxidase; Provisional; Region: PRK09077 717961001951 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 717961001952 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 717961001953 HflX GTPase family; Region: HflX; cd01878 717961001954 G1 box; other site 717961001955 GTP/Mg2+ binding site [chemical binding]; other site 717961001956 Switch I region; other site 717961001957 G2 box; other site 717961001958 G3 box; other site 717961001959 Switch II region; other site 717961001960 G4 box; other site 717961001961 G5 box; other site 717961001962 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 717961001963 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 717961001964 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 717961001965 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 717961001966 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 717961001967 dimerization domain swap beta strand [polypeptide binding]; other site 717961001968 regulatory protein interface [polypeptide binding]; other site 717961001969 active site 717961001970 regulatory phosphorylation site [posttranslational modification]; other site 717961001971 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 717961001972 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 717961001973 dimer interface [polypeptide binding]; other site 717961001974 active site 717961001975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717961001976 catalytic residues [active] 717961001977 substrate binding site [chemical binding]; other site 717961001978 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 717961001979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961001980 FeS/SAM binding site; other site 717961001981 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 717961001982 Double zinc ribbon; Region: DZR; pfam12773 717961001983 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 717961001984 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961001985 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 717961001986 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 717961001987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961001988 Walker A motif; other site 717961001989 ATP binding site [chemical binding]; other site 717961001990 Walker B motif; other site 717961001991 arginine finger; other site 717961001992 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 717961001993 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 717961001994 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 717961001995 active site 717961001996 substrate binding site [chemical binding]; other site 717961001997 metal binding site [ion binding]; metal-binding site 717961001998 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 717961001999 Fn3 associated; Region: Fn3_assoc; pfam13287 717961002000 CotH protein; Region: CotH; pfam08757 717961002001 Lamin Tail Domain; Region: LTD; pfam00932 717961002002 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 717961002003 S1 RNA binding domain; Region: S1; pfam00575 717961002004 RNA binding site [nucleotide binding]; other site 717961002005 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 717961002006 RNA binding site [nucleotide binding]; other site 717961002007 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 717961002008 AAA ATPase domain; Region: AAA_16; pfam13191 717961002009 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 717961002010 DNA polymerase III subunit delta'; Validated; Region: PRK08485 717961002011 Protein of unknown function (DUF970); Region: DUF970; cl17525 717961002012 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 717961002013 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717961002014 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717961002015 catalytic residue [active] 717961002016 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 717961002017 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 717961002018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961002019 Coenzyme A binding pocket [chemical binding]; other site 717961002020 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 717961002021 Cell division protein FtsA; Region: FtsA; smart00842 717961002022 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 717961002023 nucleotide binding site [chemical binding]; other site 717961002024 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 717961002025 putative metal binding site [ion binding]; other site 717961002026 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 717961002027 Radical SAM superfamily; Region: Radical_SAM; pfam04055 717961002028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961002029 FeS/SAM binding site; other site 717961002030 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 717961002031 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 717961002032 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 717961002033 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961002034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961002035 non-specific DNA binding site [nucleotide binding]; other site 717961002036 salt bridge; other site 717961002037 sequence-specific DNA binding site [nucleotide binding]; other site 717961002038 Homeodomain-like domain; Region: HTH_23; cl17451 717961002039 Terminase-like family; Region: Terminase_6; pfam03237 717961002040 Phage terminase large subunit; Region: Terminase_3; cl12054 717961002041 Protein of unknown function (DUF464); Region: DUF464; cl01080 717961002042 Holin family; Region: Phage_holin_4; pfam05105 717961002043 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 717961002044 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 717961002045 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717961002046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 717961002047 G5 domain; Region: G5; pfam07501 717961002048 Peptidase family M23; Region: Peptidase_M23; pfam01551 717961002049 Integral membrane protein DUF95; Region: DUF95; cl00572 717961002050 Propanediol utilisation protein PduL; Region: PduL; pfam06130 717961002051 Propanediol utilisation protein PduL; Region: PduL; pfam06130 717961002052 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 717961002053 active site 717961002054 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 717961002055 FtsX-like permease family; Region: FtsX; pfam02687 717961002056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961002057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961002058 Walker A/P-loop; other site 717961002059 ATP binding site [chemical binding]; other site 717961002060 Q-loop/lid; other site 717961002061 ABC transporter signature motif; other site 717961002062 Walker B; other site 717961002063 D-loop; other site 717961002064 H-loop/switch region; other site 717961002065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961002066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961002067 ATP binding site [chemical binding]; other site 717961002068 Mg2+ binding site [ion binding]; other site 717961002069 G-X-G motif; other site 717961002070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717961002071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961002072 active site 717961002073 phosphorylation site [posttranslational modification] 717961002074 intermolecular recognition site; other site 717961002075 dimerization interface [polypeptide binding]; other site 717961002076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717961002077 DNA binding site [nucleotide binding] 717961002078 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 717961002079 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 717961002080 FAD binding site [chemical binding]; other site 717961002081 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 717961002082 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 717961002083 active site 717961002084 HIGH motif; other site 717961002085 KMSKS motif; other site 717961002086 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 717961002087 tRNA binding surface [nucleotide binding]; other site 717961002088 anticodon binding site; other site 717961002089 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 717961002090 dimer interface [polypeptide binding]; other site 717961002091 putative tRNA-binding site [nucleotide binding]; other site 717961002092 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 717961002093 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 717961002094 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 717961002095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961002096 Walker A/P-loop; other site 717961002097 ATP binding site [chemical binding]; other site 717961002098 Q-loop/lid; other site 717961002099 ABC transporter signature motif; other site 717961002100 Walker B; other site 717961002101 D-loop; other site 717961002102 H-loop/switch region; other site 717961002103 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 717961002104 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 717961002105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 717961002106 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717961002107 Peptidase family M23; Region: Peptidase_M23; pfam01551 717961002108 C-terminal peptidase (prc); Region: prc; TIGR00225 717961002109 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 717961002110 protein binding site [polypeptide binding]; other site 717961002111 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 717961002112 Active site serine [active] 717961002113 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 717961002114 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 717961002115 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 717961002116 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 717961002117 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 717961002118 dimer interface [polypeptide binding]; other site 717961002119 putative anticodon binding site; other site 717961002120 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 717961002121 motif 1; other site 717961002122 active site 717961002123 motif 2; other site 717961002124 motif 3; other site 717961002125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961002126 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961002127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961002128 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 717961002129 DNA binding residues [nucleotide binding] 717961002130 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 717961002131 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 717961002132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961002133 ATP binding site [chemical binding]; other site 717961002134 Mg2+ binding site [ion binding]; other site 717961002135 G-X-G motif; other site 717961002136 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 717961002137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961002138 active site 717961002139 phosphorylation site [posttranslational modification] 717961002140 intermolecular recognition site; other site 717961002141 LytTr DNA-binding domain; Region: LytTR; smart00850 717961002142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961002143 Coenzyme A binding pocket [chemical binding]; other site 717961002144 Probable beta-xylosidase; Provisional; Region: PLN03080 717961002145 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 717961002146 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 717961002147 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 717961002148 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 717961002149 substrate binding site [chemical binding]; other site 717961002150 ATP binding site [chemical binding]; other site 717961002151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 717961002152 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 717961002153 signal recognition particle protein; Provisional; Region: PRK10867 717961002154 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 717961002155 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 717961002156 P loop; other site 717961002157 GTP binding site [chemical binding]; other site 717961002158 Signal peptide binding domain; Region: SRP_SPB; pfam02978 717961002159 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 717961002160 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 717961002161 KH domain; Region: KH_4; pfam13083 717961002162 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 717961002163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961002164 Zn2+ binding site [ion binding]; other site 717961002165 Mg2+ binding site [ion binding]; other site 717961002166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961002167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961002168 non-specific DNA binding site [nucleotide binding]; other site 717961002169 salt bridge; other site 717961002170 sequence-specific DNA binding site [nucleotide binding]; other site 717961002171 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 717961002172 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 717961002173 active site 717961002174 dimer interface [polypeptide binding]; other site 717961002175 metal binding site [ion binding]; metal-binding site 717961002176 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 717961002177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961002178 FeS/SAM binding site; other site 717961002179 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 717961002180 G1 box; other site 717961002181 GTP/Mg2+ binding site [chemical binding]; other site 717961002182 Switch I region; other site 717961002183 G2 box; other site 717961002184 G3 box; other site 717961002185 Switch II region; other site 717961002186 G4 box; other site 717961002187 G5 box; other site 717961002188 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 717961002189 Found in ATP-dependent protease La (LON); Region: LON; smart00464 717961002190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961002191 Walker A motif; other site 717961002192 ATP binding site [chemical binding]; other site 717961002193 Walker B motif; other site 717961002194 arginine finger; other site 717961002195 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 717961002196 ketol-acid reductoisomerase; Provisional; Region: PRK05479 717961002197 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 717961002198 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 717961002199 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 717961002200 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 717961002201 putative valine binding site [chemical binding]; other site 717961002202 dimer interface [polypeptide binding]; other site 717961002203 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 717961002204 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 717961002205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 717961002206 PYR/PP interface [polypeptide binding]; other site 717961002207 dimer interface [polypeptide binding]; other site 717961002208 TPP binding site [chemical binding]; other site 717961002209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717961002210 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 717961002211 TPP-binding site [chemical binding]; other site 717961002212 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 717961002213 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717961002214 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 717961002215 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 717961002216 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 717961002217 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 717961002218 SLBB domain; Region: SLBB; pfam10531 717961002219 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 717961002220 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 717961002221 FMN-binding domain; Region: FMN_bind; pfam04205 717961002222 electron transport complex RsxE subunit; Provisional; Region: PRK12405 717961002223 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 717961002224 ferredoxin; Validated; Region: PRK07118 717961002225 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 717961002226 4Fe-4S binding domain; Region: Fer4; cl02805 717961002227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961002228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961002229 metal binding site [ion binding]; metal-binding site 717961002230 active site 717961002231 I-site; other site 717961002232 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961002233 hybrid cluster protein; Provisional; Region: PRK05290 717961002234 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 717961002235 ACS interaction site; other site 717961002236 CODH interaction site; other site 717961002237 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 717961002238 ACS interaction site; other site 717961002239 CODH interaction site; other site 717961002240 metal cluster binding site [ion binding]; other site 717961002241 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 717961002242 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 717961002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961002244 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 717961002245 active site 717961002246 phosphorylation site [posttranslational modification] 717961002247 intermolecular recognition site; other site 717961002248 dimerization interface [polypeptide binding]; other site 717961002249 LytTr DNA-binding domain; Region: LytTR; pfam04397 717961002250 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717961002251 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 717961002252 HAMP domain; Region: HAMP; pfam00672 717961002253 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717961002254 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717961002255 dimer interface [polypeptide binding]; other site 717961002256 putative CheW interface [polypeptide binding]; other site 717961002257 QueT transporter; Region: QueT; pfam06177 717961002258 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961002259 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 717961002260 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 717961002261 Divergent AAA domain; Region: AAA_4; pfam04326 717961002262 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 717961002263 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 717961002264 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 717961002265 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 717961002266 MarR family; Region: MarR_2; cl17246 717961002267 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717961002268 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 717961002269 elongation factor G; Reviewed; Region: PRK12740 717961002270 G1 box; other site 717961002271 putative GEF interaction site [polypeptide binding]; other site 717961002272 GTP/Mg2+ binding site [chemical binding]; other site 717961002273 Switch I region; other site 717961002274 G2 box; other site 717961002275 G3 box; other site 717961002276 Switch II region; other site 717961002277 G4 box; other site 717961002278 G5 box; other site 717961002279 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 717961002280 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 717961002281 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514 717961002282 Predicted transcriptional regulators [Transcription]; Region: COG1725 717961002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717961002284 DNA-binding site [nucleotide binding]; DNA binding site 717961002285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717961002286 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717961002287 Walker A/P-loop; other site 717961002288 ATP binding site [chemical binding]; other site 717961002289 Q-loop/lid; other site 717961002290 ABC transporter signature motif; other site 717961002291 Walker B; other site 717961002292 D-loop; other site 717961002293 H-loop/switch region; other site 717961002294 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 717961002295 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 717961002296 Sensory domain found in PocR; Region: PocR; pfam10114 717961002297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717961002298 dimer interface [polypeptide binding]; other site 717961002299 putative CheW interface [polypeptide binding]; other site 717961002300 glycogen synthase; Provisional; Region: glgA; PRK00654 717961002301 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 717961002302 ADP-binding pocket [chemical binding]; other site 717961002303 homodimer interface [polypeptide binding]; other site 717961002304 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 717961002305 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 717961002306 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 717961002307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 717961002308 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 717961002309 Predicted membrane protein [Function unknown]; Region: COG2323 717961002310 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 717961002311 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 717961002312 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 717961002313 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 717961002314 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 717961002315 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 717961002316 Walker A/P-loop; other site 717961002317 ATP binding site [chemical binding]; other site 717961002318 Q-loop/lid; other site 717961002319 ABC transporter signature motif; other site 717961002320 Walker B; other site 717961002321 D-loop; other site 717961002322 H-loop/switch region; other site 717961002323 NIL domain; Region: NIL; pfam09383 717961002324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717961002325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717961002326 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717961002327 active site 717961002328 catalytic triad [active] 717961002329 oxyanion hole [active] 717961002330 HipA-like N-terminal domain; Region: HipA_N; pfam07805 717961002331 HipA-like C-terminal domain; Region: HipA_C; pfam07804 717961002332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717961002333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 717961002334 substrate binding pocket [chemical binding]; other site 717961002335 membrane-bound complex binding site; other site 717961002336 hinge residues; other site 717961002337 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 717961002338 metal-binding site [ion binding] 717961002339 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717961002340 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 717961002341 metal-binding site [ion binding] 717961002342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717961002343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961002344 motif II; other site 717961002345 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 717961002346 metal-binding site [ion binding] 717961002347 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 717961002348 putative homodimer interface [polypeptide binding]; other site 717961002349 putative homotetramer interface [polypeptide binding]; other site 717961002350 putative allosteric switch controlling residues; other site 717961002351 putative metal binding site [ion binding]; other site 717961002352 putative homodimer-homodimer interface [polypeptide binding]; other site 717961002353 4-alpha-glucanotransferase; Provisional; Region: PRK14508 717961002354 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 717961002355 homodimer interface [polypeptide binding]; other site 717961002356 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 717961002357 active site pocket [active] 717961002358 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 717961002359 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 717961002360 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 717961002361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 717961002362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961002363 dimer interface [polypeptide binding]; other site 717961002364 conserved gate region; other site 717961002365 putative PBP binding loops; other site 717961002366 ABC-ATPase subunit interface; other site 717961002367 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717961002368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961002369 dimer interface [polypeptide binding]; other site 717961002370 conserved gate region; other site 717961002371 putative PBP binding loops; other site 717961002372 ABC-ATPase subunit interface; other site 717961002373 Transcriptional regulators [Transcription]; Region: PurR; COG1609 717961002374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 717961002375 DNA binding site [nucleotide binding] 717961002376 domain linker motif; other site 717961002377 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 717961002378 ligand binding site [chemical binding]; other site 717961002379 dimerization interface [polypeptide binding]; other site 717961002380 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 717961002381 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 717961002382 Ca binding site [ion binding]; other site 717961002383 active site 717961002384 catalytic site [active] 717961002385 pullulanase, type I; Region: pulA_typeI; TIGR02104 717961002386 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 717961002387 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 717961002388 Ca binding site [ion binding]; other site 717961002389 active site 717961002390 catalytic site [active] 717961002391 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 717961002392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961002393 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 717961002394 active site 717961002395 DNA binding site [nucleotide binding] 717961002396 Int/Topo IB signature motif; other site 717961002397 Domain of unknown function (DUF955); Region: DUF955; pfam06114 717961002398 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717961002399 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717961002400 P-loop; other site 717961002401 Magnesium ion binding site [ion binding]; other site 717961002402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717961002403 Magnesium ion binding site [ion binding]; other site 717961002404 ParB-like nuclease domain; Region: ParBc; pfam02195 717961002405 Cna protein B-type domain; Region: Cna_B; pfam05738 717961002406 Cna protein B-type domain; Region: Cna_B; pfam05738 717961002407 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 717961002408 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 717961002409 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 717961002410 active site 717961002411 metal binding site [ion binding]; metal-binding site 717961002412 interdomain interaction site; other site 717961002413 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 717961002414 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 717961002415 Domain of unknown function DUF87; Region: DUF87; pfam01935 717961002416 AAA-like domain; Region: AAA_10; pfam12846 717961002417 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 717961002418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961002419 non-specific DNA binding site [nucleotide binding]; other site 717961002420 salt bridge; other site 717961002421 sequence-specific DNA binding site [nucleotide binding]; other site 717961002422 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 717961002423 Helix-turn-helix domain; Region: HTH_36; pfam13730 717961002424 Helix-turn-helix domain; Region: HTH_36; pfam13730 717961002425 RelB antitoxin; Region: RelB; cl01171 717961002426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 717961002427 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 717961002428 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 717961002429 active site 717961002430 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 717961002431 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 717961002432 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717961002433 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 717961002434 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 717961002435 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717961002436 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717961002437 FtsX-like permease family; Region: FtsX; pfam02687 717961002438 FtsX-like permease family; Region: FtsX; pfam02687 717961002439 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961002440 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961002441 Walker A/P-loop; other site 717961002442 ATP binding site [chemical binding]; other site 717961002443 Q-loop/lid; other site 717961002444 ABC transporter signature motif; other site 717961002445 Walker B; other site 717961002446 D-loop; other site 717961002447 H-loop/switch region; other site 717961002448 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 717961002449 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 717961002450 active site 717961002451 metal binding site [ion binding]; metal-binding site 717961002452 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 717961002453 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717961002454 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 717961002455 active site 717961002456 catalytic triad [active] 717961002457 dimer interface [polypeptide binding]; other site 717961002458 EDD domain protein, DegV family; Region: DegV; TIGR00762 717961002459 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 717961002460 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 717961002461 active site 717961002462 catalytic triad [active] 717961002463 oxyanion hole [active] 717961002464 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717961002465 active site 717961002466 catalytic triad [active] 717961002467 oxyanion hole [active] 717961002468 glycogen branching enzyme; Provisional; Region: PRK12313 717961002469 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 717961002470 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 717961002471 active site 717961002472 catalytic site [active] 717961002473 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 717961002474 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 717961002475 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 717961002476 ligand binding site; other site 717961002477 oligomer interface; other site 717961002478 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 717961002479 dimer interface [polypeptide binding]; other site 717961002480 N-terminal domain interface [polypeptide binding]; other site 717961002481 sulfate 1 binding site; other site 717961002482 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 717961002483 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 717961002484 ligand binding site; other site 717961002485 oligomer interface; other site 717961002486 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 717961002487 dimer interface [polypeptide binding]; other site 717961002488 N-terminal domain interface [polypeptide binding]; other site 717961002489 sulfate 1 binding site; other site 717961002490 2-ketoisovalerate ferredoxin oxidoreductase subunit delta; Reviewed; Region: vorD; PRK09623 717961002491 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 717961002492 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 717961002493 dimer interface [polypeptide binding]; other site 717961002494 PYR/PP interface [polypeptide binding]; other site 717961002495 TPP binding site [chemical binding]; other site 717961002496 substrate binding site [chemical binding]; other site 717961002497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717961002498 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 717961002499 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 717961002500 TPP-binding site [chemical binding]; other site 717961002501 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 717961002502 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 717961002503 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 717961002504 Clp amino terminal domain; Region: Clp_N; pfam02861 717961002505 Clp amino terminal domain; Region: Clp_N; pfam02861 717961002506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961002507 Walker A motif; other site 717961002508 ATP binding site [chemical binding]; other site 717961002509 Walker B motif; other site 717961002510 arginine finger; other site 717961002511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961002512 Walker A motif; other site 717961002513 ATP binding site [chemical binding]; other site 717961002514 Walker B motif; other site 717961002515 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717961002516 Abi-like protein; Region: Abi_2; pfam07751 717961002517 hypothetical protein; Provisional; Region: PRK11820 717961002518 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 717961002519 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 717961002520 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 717961002521 Aluminium resistance protein; Region: Alum_res; pfam06838 717961002522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961002523 Coenzyme A binding pocket [chemical binding]; other site 717961002524 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 717961002525 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 717961002526 oligomer interface [polypeptide binding]; other site 717961002527 active site 717961002528 metal binding site [ion binding]; metal-binding site 717961002529 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 717961002530 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 717961002531 oligomer interface [polypeptide binding]; other site 717961002532 active site 717961002533 metal binding site [ion binding]; metal-binding site 717961002534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717961002535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717961002536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717961002537 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 717961002538 4Fe-4S binding domain; Region: Fer4; pfam00037 717961002539 4Fe-4S binding domain; Region: Fer4; pfam00037 717961002540 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 717961002541 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 717961002542 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 717961002543 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 717961002544 Putative Fe-S cluster; Region: FeS; cl17515 717961002545 PAS fold; Region: PAS; pfam00989 717961002546 PAS domain; Region: PAS; smart00091 717961002547 Predicted thioesterase [General function prediction only]; Region: COG5496 717961002548 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 717961002549 dimer interface [polypeptide binding]; other site 717961002550 [2Fe-2S] cluster binding site [ion binding]; other site 717961002551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717961002552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717961002553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961002554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961002555 Walker A/P-loop; other site 717961002556 ATP binding site [chemical binding]; other site 717961002557 Q-loop/lid; other site 717961002558 ABC transporter signature motif; other site 717961002559 Walker B; other site 717961002560 D-loop; other site 717961002561 H-loop/switch region; other site 717961002562 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 717961002563 FtsX-like permease family; Region: FtsX; pfam02687 717961002564 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 717961002565 FtsX-like permease family; Region: FtsX; pfam02687 717961002566 PemK-like protein; Region: PemK; pfam02452 717961002567 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 717961002568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717961002569 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 717961002570 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 717961002571 AzlC protein; Region: AzlC; cl00570 717961002572 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717961002573 active site 717961002574 catalytic triad [active] 717961002575 oxyanion hole [active] 717961002576 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 717961002577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717961002578 substrate binding pocket [chemical binding]; other site 717961002579 membrane-bound complex binding site; other site 717961002580 hinge residues; other site 717961002581 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 717961002582 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 717961002583 Walker A/P-loop; other site 717961002584 ATP binding site [chemical binding]; other site 717961002585 Q-loop/lid; other site 717961002586 ABC transporter signature motif; other site 717961002587 Walker B; other site 717961002588 D-loop; other site 717961002589 H-loop/switch region; other site 717961002590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 717961002591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961002592 dimer interface [polypeptide binding]; other site 717961002593 conserved gate region; other site 717961002594 putative PBP binding loops; other site 717961002595 ABC-ATPase subunit interface; other site 717961002596 Flavin Reductases; Region: FlaRed; cl00801 717961002597 topology modulation protein; Reviewed; Region: PRK08118 717961002598 AAA domain; Region: AAA_17; pfam13207 717961002599 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 717961002600 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 717961002601 homotetramer interface [polypeptide binding]; other site 717961002602 ligand binding site [chemical binding]; other site 717961002603 catalytic site [active] 717961002604 NAD binding site [chemical binding]; other site 717961002605 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 717961002606 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 717961002607 active site 717961002608 putative substrate binding pocket [chemical binding]; other site 717961002609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961002610 Coenzyme A binding pocket [chemical binding]; other site 717961002611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961002612 Coenzyme A binding pocket [chemical binding]; other site 717961002613 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 717961002614 catalytic triad [active] 717961002615 active site nucleophile [active] 717961002616 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717961002617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961002618 S-adenosylmethionine binding site [chemical binding]; other site 717961002619 Protein of unknown function (DUF964); Region: DUF964; pfam06133 717961002620 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 717961002621 MutS domain I; Region: MutS_I; pfam01624 717961002622 MutS domain II; Region: MutS_II; pfam05188 717961002623 MutS domain III; Region: MutS_III; pfam05192 717961002624 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 717961002625 Walker A/P-loop; other site 717961002626 ATP binding site [chemical binding]; other site 717961002627 Q-loop/lid; other site 717961002628 ABC transporter signature motif; other site 717961002629 Walker B; other site 717961002630 D-loop; other site 717961002631 H-loop/switch region; other site 717961002632 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 717961002633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961002634 ATP binding site [chemical binding]; other site 717961002635 Mg2+ binding site [ion binding]; other site 717961002636 G-X-G motif; other site 717961002637 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 717961002638 ATP binding site [chemical binding]; other site 717961002639 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 717961002640 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 717961002641 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 717961002642 bacterial Hfq-like; Region: Hfq; cd01716 717961002643 hexamer interface [polypeptide binding]; other site 717961002644 Sm1 motif; other site 717961002645 RNA binding site [nucleotide binding]; other site 717961002646 Sm2 motif; other site 717961002647 HlyD family secretion protein; Region: HlyD_2; pfam12700 717961002648 Quinolinate phosphoribosyl transferase, N-terminal domain; Region: QRPTase_N; pfam02749 717961002649 putative membrane fusion protein; Region: TIGR02828 717961002650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 717961002651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717961002652 catalytic residue [active] 717961002653 Protein of unknown function (DUF552); Region: DUF552; pfam04472 717961002654 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 717961002655 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961002656 RNA binding surface [nucleotide binding]; other site 717961002657 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 717961002658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961002659 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 717961002660 active site 717961002661 motif I; other site 717961002662 motif II; other site 717961002663 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 717961002664 Surface antigen [General function prediction only]; Region: COG3942 717961002665 CHAP domain; Region: CHAP; pfam05257 717961002666 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961002667 Interdomain contacts; other site 717961002668 Cytokine receptor motif; other site 717961002669 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961002670 Interdomain contacts; other site 717961002671 Cytokine receptor motif; other site 717961002672 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961002673 Interdomain contacts; other site 717961002674 Cytokine receptor motif; other site 717961002675 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 717961002676 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 717961002677 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 717961002678 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 717961002679 23S rRNA binding site [nucleotide binding]; other site 717961002680 L21 binding site [polypeptide binding]; other site 717961002681 L13 binding site [polypeptide binding]; other site 717961002682 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 717961002683 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 717961002684 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 717961002685 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 717961002686 Glucose inhibited division protein A; Region: GIDA; pfam01134 717961002687 putative phosphate acyltransferase; Provisional; Region: PRK05331 717961002688 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 717961002689 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 717961002690 dimerization interface [polypeptide binding]; other site 717961002691 active site 717961002692 metal binding site [ion binding]; metal-binding site 717961002693 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 717961002694 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 717961002695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961002696 FeS/SAM binding site; other site 717961002697 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 717961002698 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 717961002699 Walker A/P-loop; other site 717961002700 ATP binding site [chemical binding]; other site 717961002701 Q-loop/lid; other site 717961002702 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 717961002703 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 717961002704 Q-loop/lid; other site 717961002705 ABC transporter signature motif; other site 717961002706 Walker B; other site 717961002707 D-loop; other site 717961002708 H-loop/switch region; other site 717961002709 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 717961002710 Active site serine [active] 717961002711 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 717961002712 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 717961002713 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 717961002714 P loop; other site 717961002715 GTP binding site [chemical binding]; other site 717961002716 Predicted membrane protein [Function unknown]; Region: COG3326 717961002717 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 717961002718 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 717961002719 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 717961002720 active site 717961002721 (T/H)XGH motif; other site 717961002722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961002723 Zn2+ binding site [ion binding]; other site 717961002724 Mg2+ binding site [ion binding]; other site 717961002725 Oligomerisation domain; Region: Oligomerisation; pfam02410 717961002726 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 717961002727 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 717961002728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961002729 active site 717961002730 motif I; other site 717961002731 motif II; other site 717961002732 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 717961002733 AP (apurinic/apyrimidinic) site pocket; other site 717961002734 AP endonuclease family 2; Region: AP2Ec; smart00518 717961002735 Metal-binding active site; metal-binding site 717961002736 Dehydroquinase class II; Region: DHquinase_II; pfam01220 717961002737 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 717961002738 trimer interface [polypeptide binding]; other site 717961002739 active site 717961002740 dimer interface [polypeptide binding]; other site 717961002741 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 717961002742 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 717961002743 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 717961002744 active site 717961002745 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 717961002746 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 717961002747 ArsC family; Region: ArsC; pfam03960 717961002748 catalytic residue [active] 717961002749 TPR repeat; Region: TPR_11; pfam13414 717961002750 Sel1-like repeats; Region: SEL1; smart00671 717961002751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717961002752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 717961002753 substrate binding pocket [chemical binding]; other site 717961002754 membrane-bound complex binding site; other site 717961002755 hinge residues; other site 717961002756 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 717961002757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961002758 Walker A/P-loop; other site 717961002759 ATP binding site [chemical binding]; other site 717961002760 Q-loop/lid; other site 717961002761 ABC transporter signature motif; other site 717961002762 Walker B; other site 717961002763 D-loop; other site 717961002764 H-loop/switch region; other site 717961002765 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 717961002766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961002767 Interdomain contacts; other site 717961002768 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961002769 Interdomain contacts; other site 717961002770 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 717961002771 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 717961002772 folate binding site [chemical binding]; other site 717961002773 NADP+ binding site [chemical binding]; other site 717961002774 MraW methylase family; Region: Methyltransf_5; pfam01795 717961002775 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 717961002776 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 717961002777 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 717961002778 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 717961002779 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 717961002780 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 717961002781 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 717961002782 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 717961002783 Mg++ binding site [ion binding]; other site 717961002784 putative catalytic motif [active] 717961002785 putative substrate binding site [chemical binding]; other site 717961002786 cell division protein FtsW; Region: ftsW; TIGR02614 717961002787 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 717961002788 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 717961002789 active site 717961002790 homodimer interface [polypeptide binding]; other site 717961002791 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 717961002792 cell division protein FtsZ; Validated; Region: PRK09330 717961002793 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 717961002794 nucleotide binding site [chemical binding]; other site 717961002795 SulA interaction site; other site 717961002796 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961002797 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961002798 Walker A/P-loop; other site 717961002799 ATP binding site [chemical binding]; other site 717961002800 Q-loop/lid; other site 717961002801 ABC transporter signature motif; other site 717961002802 Walker B; other site 717961002803 D-loop; other site 717961002804 H-loop/switch region; other site 717961002805 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961002806 FtsX-like permease family; Region: FtsX; pfam02687 717961002807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961002808 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717961002809 dimerization interface [polypeptide binding]; other site 717961002810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717961002811 dimer interface [polypeptide binding]; other site 717961002812 phosphorylation site [posttranslational modification] 717961002813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961002814 ATP binding site [chemical binding]; other site 717961002815 Mg2+ binding site [ion binding]; other site 717961002816 G-X-G motif; other site 717961002817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717961002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961002819 active site 717961002820 phosphorylation site [posttranslational modification] 717961002821 intermolecular recognition site; other site 717961002822 dimerization interface [polypeptide binding]; other site 717961002823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717961002824 DNA binding site [nucleotide binding] 717961002825 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 717961002826 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 717961002827 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 717961002828 GMP synthase; Reviewed; Region: guaA; PRK00074 717961002829 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 717961002830 AMP/PPi binding site [chemical binding]; other site 717961002831 candidate oxyanion hole; other site 717961002832 catalytic triad [active] 717961002833 potential glutamine specificity residues [chemical binding]; other site 717961002834 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 717961002835 ATP Binding subdomain [chemical binding]; other site 717961002836 Ligand Binding sites [chemical binding]; other site 717961002837 Dimerization subdomain; other site 717961002838 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 717961002839 catalytic residues [active] 717961002840 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 717961002841 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 717961002842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 717961002843 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 717961002844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961002845 Walker B motif; other site 717961002846 arginine finger; other site 717961002847 Peptidase family M41; Region: Peptidase_M41; pfam01434 717961002848 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 717961002849 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 717961002850 Ligand Binding Site [chemical binding]; other site 717961002851 replicative DNA helicase; Region: DnaB; TIGR00665 717961002852 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 717961002853 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 717961002854 Walker A motif; other site 717961002855 ATP binding site [chemical binding]; other site 717961002856 Walker B motif; other site 717961002857 DNA binding loops [nucleotide binding] 717961002858 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 717961002859 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 717961002860 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 717961002861 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 717961002862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717961002863 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 717961002864 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717961002865 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717961002866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717961002867 catalytic residue [active] 717961002868 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 717961002869 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 717961002870 TPP-binding site; other site 717961002871 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717961002872 PYR/PP interface [polypeptide binding]; other site 717961002873 dimer interface [polypeptide binding]; other site 717961002874 TPP binding site [chemical binding]; other site 717961002875 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717961002876 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 717961002877 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 717961002878 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 717961002879 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 717961002880 glutamate dehydrogenase; Provisional; Region: PRK09414 717961002881 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 717961002882 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 717961002883 NAD(P) binding site [chemical binding]; other site 717961002884 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 717961002885 SmpB-tmRNA interface; other site 717961002886 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 717961002887 dinuclear metal binding motif [ion binding]; other site 717961002888 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961002889 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 717961002890 catalytic residues [active] 717961002891 catalytic nucleophile [active] 717961002892 Recombinase; Region: Recombinase; pfam07508 717961002893 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961002894 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 717961002895 BRO family, N-terminal domain; Region: Bro-N; pfam02498 717961002896 comF family protein; Region: comF; TIGR00201 717961002897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717961002898 active site 717961002899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961002900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961002901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961002902 Walker A/P-loop; other site 717961002903 ATP binding site [chemical binding]; other site 717961002904 Q-loop/lid; other site 717961002905 ABC transporter signature motif; other site 717961002906 Walker B; other site 717961002907 D-loop; other site 717961002908 H-loop/switch region; other site 717961002909 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961002910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961002911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961002912 Walker A/P-loop; other site 717961002913 ATP binding site [chemical binding]; other site 717961002914 Q-loop/lid; other site 717961002915 ABC transporter signature motif; other site 717961002916 Walker B; other site 717961002917 D-loop; other site 717961002918 H-loop/switch region; other site 717961002919 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961002920 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 717961002921 Walker A/P-loop; other site 717961002922 ATP binding site [chemical binding]; other site 717961002923 Q-loop/lid; other site 717961002924 ABC transporter signature motif; other site 717961002925 Walker B; other site 717961002926 D-loop; other site 717961002927 H-loop/switch region; other site 717961002928 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 717961002929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961002930 Walker A/P-loop; other site 717961002931 ATP binding site [chemical binding]; other site 717961002932 Q-loop/lid; other site 717961002933 ABC transporter signature motif; other site 717961002934 Walker B; other site 717961002935 D-loop; other site 717961002936 H-loop/switch region; other site 717961002937 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 717961002938 Tubby C 2; Region: Tub_2; cl02043 717961002939 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 717961002940 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 717961002941 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 717961002942 Zn binding sites [ion binding]; other site 717961002943 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 717961002944 pyridoxal binding site [chemical binding]; other site 717961002945 dimer interface [polypeptide binding]; other site 717961002946 ATP binding site [chemical binding]; other site 717961002947 Ribosomal L28e protein family; Region: Ribosomal_L28e; cl03350 717961002948 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 717961002949 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 717961002950 Prophage antirepressor [Transcription]; Region: COG3617 717961002951 BRO family, N-terminal domain; Region: Bro-N; smart01040 717961002952 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 717961002953 Protein of unknown function (DUF3849); Region: DUF3849; pfam12960 717961002954 SpoVG; Region: SpoVG; pfam04026 717961002955 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 717961002956 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 717961002957 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 717961002958 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717961002959 Walker A motif; other site 717961002960 ATP binding site [chemical binding]; other site 717961002961 Walker B motif; other site 717961002962 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 717961002963 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 717961002964 Antirestriction protein (ArdA); Region: ArdA; cl01953 717961002965 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 717961002966 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 717961002967 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 717961002968 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961002969 active site 717961002970 DNA binding site [nucleotide binding] 717961002971 Int/Topo IB signature motif; other site 717961002972 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717961002973 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717961002974 Sel1-like repeats; Region: SEL1; smart00671 717961002975 Sel1-like repeats; Region: SEL1; smart00671 717961002976 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 717961002977 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 717961002978 active site 717961002979 metal binding site [ion binding]; metal-binding site 717961002980 interdomain interaction site; other site 717961002981 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961002982 DNA binding site [nucleotide binding] 717961002983 active site 717961002984 Int/Topo IB signature motif; other site 717961002985 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 717961002986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961002987 active site 717961002988 phosphorylation site [posttranslational modification] 717961002989 intermolecular recognition site; other site 717961002990 dimerization interface [polypeptide binding]; other site 717961002991 LytTr DNA-binding domain; Region: LytTR; pfam04397 717961002992 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 717961002993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961002994 ATP binding site [chemical binding]; other site 717961002995 Mg2+ binding site [ion binding]; other site 717961002996 G-X-G motif; other site 717961002997 Staphylococcal AgrD protein; Region: AgrD; cl05477 717961002998 Accessory gene regulator B; Region: AgrB; pfam04647 717961002999 PemK-like protein; Region: PemK; pfam02452 717961003000 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961003001 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 717961003002 catalytic residues [active] 717961003003 catalytic nucleophile [active] 717961003004 Recombinase; Region: Recombinase; pfam07508 717961003005 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961003006 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961003007 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 717961003008 catalytic residues [active] 717961003009 catalytic nucleophile [active] 717961003010 Recombinase; Region: Recombinase; pfam07508 717961003011 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961003012 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 717961003013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717961003014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717961003015 putative substrate translocation pore; other site 717961003016 Cupin domain; Region: Cupin_2; pfam07883 717961003017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961003018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961003019 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 717961003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 717961003021 active site 717961003022 phosphorylation site [posttranslational modification] 717961003023 intermolecular recognition site; other site 717961003024 dimerization interface [polypeptide binding]; other site 717961003025 LytTr DNA-binding domain; Region: LytTR; smart00850 717961003026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961003027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961003028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961003029 salt bridge; other site 717961003030 non-specific DNA binding site [nucleotide binding]; other site 717961003031 sequence-specific DNA binding site [nucleotide binding]; other site 717961003032 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 717961003033 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 717961003034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961003035 FeS/SAM binding site; other site 717961003036 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717961003037 metal binding site 2 [ion binding]; metal-binding site 717961003038 putative DNA binding helix; other site 717961003039 metal binding site 1 [ion binding]; metal-binding site 717961003040 dimer interface [polypeptide binding]; other site 717961003041 structural Zn2+ binding site [ion binding]; other site 717961003042 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 717961003043 toxin interface [polypeptide binding]; other site 717961003044 Zn binding site [ion binding]; other site 717961003045 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 717961003046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961003047 FeS/SAM binding site; other site 717961003048 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717961003049 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 717961003050 peptide binding site [polypeptide binding]; other site 717961003051 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 717961003052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717961003053 active site 717961003054 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 717961003055 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961003056 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961003057 Interdomain contacts; other site 717961003058 Cytokine receptor motif; other site 717961003059 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961003060 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961003061 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961003062 Interdomain contacts; other site 717961003063 Cytokine receptor motif; other site 717961003064 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717961003065 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 717961003066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961003067 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717961003068 putative binding surface; other site 717961003069 active site 717961003070 P2 response regulator binding domain; Region: P2; pfam07194 717961003071 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 717961003072 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 717961003073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961003074 ATP binding site [chemical binding]; other site 717961003075 Mg2+ binding site [ion binding]; other site 717961003076 G-X-G motif; other site 717961003077 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 717961003078 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 717961003079 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 717961003080 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 717961003081 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 717961003082 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 717961003083 dimerization interface [polypeptide binding]; other site 717961003084 ATP binding site [chemical binding]; other site 717961003085 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 717961003086 dimerization interface [polypeptide binding]; other site 717961003087 ATP binding site [chemical binding]; other site 717961003088 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 717961003089 putative active site [active] 717961003090 catalytic triad [active] 717961003091 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 717961003092 regulatory protein interface [polypeptide binding]; other site 717961003093 regulatory phosphorylation site [posttranslational modification]; other site 717961003094 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 717961003095 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 717961003096 intersubunit interface [polypeptide binding]; other site 717961003097 active site 717961003098 Zn2+ binding site [ion binding]; other site 717961003099 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 717961003100 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 717961003101 Domain of unknown function DUF21; Region: DUF21; pfam01595 717961003102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717961003103 Transporter associated domain; Region: CorC_HlyC; smart01091 717961003104 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 717961003105 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 717961003106 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 717961003107 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 717961003108 active site 717961003109 HIGH motif; other site 717961003110 KMSK motif region; other site 717961003111 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 717961003112 tRNA binding surface [nucleotide binding]; other site 717961003113 anticodon binding site; other site 717961003114 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 717961003115 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 717961003116 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 717961003117 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 717961003118 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 717961003119 dimer interface [polypeptide binding]; other site 717961003120 ADP-ribose binding site [chemical binding]; other site 717961003121 active site 717961003122 nudix motif; other site 717961003123 metal binding site [ion binding]; metal-binding site 717961003124 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 717961003125 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717961003126 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717961003127 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717961003128 Nuclease-related domain; Region: NERD; pfam08378 717961003129 HRDC domain; Region: HRDC; pfam00570 717961003130 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717961003131 active site 717961003132 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 717961003133 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 717961003134 putative binding surface; other site 717961003135 active site 717961003136 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 717961003137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961003138 Coenzyme A binding pocket [chemical binding]; other site 717961003139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717961003140 dimerization interface [polypeptide binding]; other site 717961003141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717961003142 PAS fold; Region: PAS_3; pfam08447 717961003143 heme pocket [chemical binding]; other site 717961003144 putative active site [active] 717961003145 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961003146 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961003147 metal binding site [ion binding]; metal-binding site 717961003148 active site 717961003149 I-site; other site 717961003150 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 717961003151 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 717961003152 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 717961003153 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 717961003154 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 717961003155 Cache domain; Region: Cache_1; pfam02743 717961003156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717961003157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717961003158 dimer interface [polypeptide binding]; other site 717961003159 putative CheW interface [polypeptide binding]; other site 717961003160 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 717961003161 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 717961003162 Cl- selectivity filter; other site 717961003163 Cl- binding residues [ion binding]; other site 717961003164 pore gating glutamate residue; other site 717961003165 dimer interface [polypeptide binding]; other site 717961003166 Biotin operon repressor [Transcription]; Region: BirA; COG1654 717961003167 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 717961003168 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 717961003169 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 717961003170 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 717961003171 elongation factor P; Validated; Region: PRK00529 717961003172 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 717961003173 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 717961003174 RNA binding site [nucleotide binding]; other site 717961003175 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 717961003176 RNA binding site [nucleotide binding]; other site 717961003177 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 717961003178 active site 717961003179 catalytic residues [active] 717961003180 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 717961003181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961003182 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961003183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961003184 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 717961003185 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 717961003186 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717961003187 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 717961003188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961003189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961003190 Walker A/P-loop; other site 717961003191 ATP binding site [chemical binding]; other site 717961003192 Q-loop/lid; other site 717961003193 ABC transporter signature motif; other site 717961003194 Walker B; other site 717961003195 D-loop; other site 717961003196 H-loop/switch region; other site 717961003197 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 717961003198 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 717961003199 active site 717961003200 dimer interface [polypeptide binding]; other site 717961003201 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 717961003202 dimer interface [polypeptide binding]; other site 717961003203 active site 717961003204 GTP-binding protein Der; Reviewed; Region: PRK00093 717961003205 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 717961003206 G1 box; other site 717961003207 GTP/Mg2+ binding site [chemical binding]; other site 717961003208 Switch I region; other site 717961003209 G2 box; other site 717961003210 Switch II region; other site 717961003211 G3 box; other site 717961003212 G4 box; other site 717961003213 G5 box; other site 717961003214 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 717961003215 G1 box; other site 717961003216 GTP/Mg2+ binding site [chemical binding]; other site 717961003217 Switch I region; other site 717961003218 G2 box; other site 717961003219 G3 box; other site 717961003220 Switch II region; other site 717961003221 G4 box; other site 717961003222 G5 box; other site 717961003223 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 717961003224 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 717961003225 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 717961003226 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 717961003227 sporulation sigma factor SigK; Reviewed; Region: PRK05803 717961003228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961003229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961003230 DNA binding residues [nucleotide binding] 717961003231 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 717961003232 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 717961003233 stage V sporulation protein AD; Provisional; Region: PRK12404 717961003234 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 717961003235 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 717961003236 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 717961003237 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 717961003238 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 717961003239 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 717961003240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 717961003241 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 717961003242 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 717961003243 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 717961003244 CT1975-like protein; Region: Cas_CT1975; pfam09344 717961003245 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 717961003246 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 717961003247 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 717961003248 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 717961003249 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 717961003250 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 717961003251 active site 717961003252 catalytic site [active] 717961003253 substrate binding site [chemical binding]; other site 717961003254 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 717961003255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717961003256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717961003257 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 717961003258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717961003259 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717961003260 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 717961003261 IMP binding site; other site 717961003262 dimer interface [polypeptide binding]; other site 717961003263 interdomain contacts; other site 717961003264 partial ornithine binding site; other site 717961003265 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961003266 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717961003267 catalytic residues [active] 717961003268 catalytic nucleophile [active] 717961003269 Presynaptic Site I dimer interface [polypeptide binding]; other site 717961003270 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717961003271 Synaptic Flat tetramer interface [polypeptide binding]; other site 717961003272 Synaptic Site I dimer interface [polypeptide binding]; other site 717961003273 DNA binding site [nucleotide binding] 717961003274 Recombinase; Region: Recombinase; pfam07508 717961003275 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961003276 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961003277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961003278 DNA binding residues [nucleotide binding] 717961003279 VanZ like family; Region: VanZ; cl01971 717961003280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961003281 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961003282 Walker A/P-loop; other site 717961003283 ATP binding site [chemical binding]; other site 717961003284 Q-loop/lid; other site 717961003285 ABC transporter signature motif; other site 717961003286 Walker B; other site 717961003287 D-loop; other site 717961003288 H-loop/switch region; other site 717961003289 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 717961003290 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717961003291 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717961003292 Walker A/P-loop; other site 717961003293 ATP binding site [chemical binding]; other site 717961003294 Q-loop/lid; other site 717961003295 ABC transporter signature motif; other site 717961003296 Walker B; other site 717961003297 D-loop; other site 717961003298 H-loop/switch region; other site 717961003299 Predicted transcriptional regulators [Transcription]; Region: COG1725 717961003300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717961003301 DNA-binding site [nucleotide binding]; DNA binding site 717961003302 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961003303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961003304 non-specific DNA binding site [nucleotide binding]; other site 717961003305 salt bridge; other site 717961003306 sequence-specific DNA binding site [nucleotide binding]; other site 717961003307 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 717961003308 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 717961003309 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 717961003310 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 717961003311 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 717961003312 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 717961003313 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 717961003314 NlpC/P60 family; Region: NLPC_P60; pfam00877 717961003315 PrgI family protein; Region: PrgI; pfam12666 717961003316 SpoVG; Region: SpoVG; pfam04026 717961003317 MT-A70; Region: MT-A70; cl01947 717961003318 PrgI family protein; Region: PrgI; pfam12666 717961003319 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717961003320 DNA methylase; Region: N6_N4_Mtase; cl17433 717961003321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961003322 S-adenosylmethionine binding site [chemical binding]; other site 717961003323 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 717961003324 hypothetical protein; Provisional; Region: PRK08557 717961003325 Ligand Binding Site [chemical binding]; other site 717961003326 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 717961003327 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 717961003328 DNA topoisomerase III; Provisional; Region: PRK07726 717961003329 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 717961003330 active site 717961003331 putative interdomain interaction site [polypeptide binding]; other site 717961003332 putative metal-binding site [ion binding]; other site 717961003333 putative nucleotide binding site [chemical binding]; other site 717961003334 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 717961003335 domain I; other site 717961003336 DNA binding groove [nucleotide binding] 717961003337 phosphate binding site [ion binding]; other site 717961003338 domain II; other site 717961003339 domain III; other site 717961003340 nucleotide binding site [chemical binding]; other site 717961003341 catalytic site [active] 717961003342 domain IV; other site 717961003343 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 717961003344 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 717961003345 Antirestriction protein (ArdA); Region: ArdA; cl01953 717961003346 Domain of unknown function (DUF955); Region: DUF955; cl01076 717961003347 YodL-like; Region: YodL; pfam14191 717961003348 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 717961003349 Domain of unknown function (DUF4319); Region: DUF4319; pfam14203 717961003350 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 717961003351 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 717961003352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961003353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961003354 non-specific DNA binding site [nucleotide binding]; other site 717961003355 salt bridge; other site 717961003356 sequence-specific DNA binding site [nucleotide binding]; other site 717961003357 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 717961003358 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 717961003359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961003360 FeS/SAM binding site; other site 717961003361 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961003362 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 717961003363 DNA binding residues [nucleotide binding] 717961003364 Helix-turn-helix domain; Region: HTH_16; pfam12645 717961003365 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961003366 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 717961003367 putative catalytic residues [active] 717961003368 catalytic nucleophile [active] 717961003369 Recombinase; Region: Recombinase; pfam07508 717961003370 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961003371 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 717961003372 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 717961003373 catalytic nucleophile [active] 717961003374 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 717961003375 hypothetical protein; Validated; Region: PRK08116 717961003376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961003377 Walker A motif; other site 717961003378 ATP binding site [chemical binding]; other site 717961003379 Walker B motif; other site 717961003380 arginine finger; other site 717961003381 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 717961003382 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 717961003383 Helix-turn-helix domain; Region: HTH_16; pfam12645 717961003384 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961003385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961003386 DNA binding residues [nucleotide binding] 717961003387 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717961003388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961003389 S-adenosylmethionine binding site [chemical binding]; other site 717961003390 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 717961003391 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 717961003392 G1 box; other site 717961003393 putative GEF interaction site [polypeptide binding]; other site 717961003394 GTP/Mg2+ binding site [chemical binding]; other site 717961003395 Switch I region; other site 717961003396 G2 box; other site 717961003397 G3 box; other site 717961003398 Switch II region; other site 717961003399 G4 box; other site 717961003400 G5 box; other site 717961003401 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 717961003402 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 717961003403 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 717961003404 Maff2 family; Region: Maff2; pfam12750 717961003405 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 717961003406 Antirestriction protein (ArdA); Region: ArdA; cl01953 717961003407 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 717961003408 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 717961003409 cofactor binding site; other site 717961003410 DNA binding site [nucleotide binding] 717961003411 substrate interaction site [chemical binding]; other site 717961003412 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 717961003413 ParB-like nuclease domain; Region: ParBc; pfam02195 717961003414 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 717961003415 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 717961003416 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 717961003417 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717961003418 minor groove reading motif; other site 717961003419 helix-hairpin-helix signature motif; other site 717961003420 substrate binding pocket [chemical binding]; other site 717961003421 active site 717961003422 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 717961003423 Helix-hairpin-helix motif; Region: HHH; pfam00633 717961003424 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 717961003425 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 717961003426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961003427 non-specific DNA binding site [nucleotide binding]; other site 717961003428 salt bridge; other site 717961003429 sequence-specific DNA binding site [nucleotide binding]; other site 717961003430 Cupin domain; Region: Cupin_2; pfam07883 717961003431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717961003432 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 717961003433 acyl-activating enzyme (AAE) consensus motif; other site 717961003434 AMP binding site [chemical binding]; other site 717961003435 active site 717961003436 CoA binding site [chemical binding]; other site 717961003437 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 717961003438 DNA protecting protein DprA; Region: dprA; TIGR00732 717961003439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 717961003440 Heavy-metal-associated domain; Region: HMA; pfam00403 717961003441 metal-binding site [ion binding] 717961003442 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717961003443 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 717961003444 metal-binding site [ion binding] 717961003445 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717961003446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961003447 motif II; other site 717961003448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717961003449 dimerization interface [polypeptide binding]; other site 717961003450 putative DNA binding site [nucleotide binding]; other site 717961003451 putative Zn2+ binding site [ion binding]; other site 717961003452 argininosuccinate synthase; Provisional; Region: PRK13820 717961003453 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 717961003454 ANP binding site [chemical binding]; other site 717961003455 Substrate Binding Site II [chemical binding]; other site 717961003456 Substrate Binding Site I [chemical binding]; other site 717961003457 argininosuccinate lyase; Provisional; Region: PRK00855 717961003458 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 717961003459 active sites [active] 717961003460 tetramer interface [polypeptide binding]; other site 717961003461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961003462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 717961003463 Coenzyme A binding pocket [chemical binding]; other site 717961003464 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 717961003465 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 717961003466 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 717961003467 heterotetramer interface [polypeptide binding]; other site 717961003468 active site pocket [active] 717961003469 cleavage site 717961003470 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 717961003471 feedback inhibition sensing region; other site 717961003472 homohexameric interface [polypeptide binding]; other site 717961003473 nucleotide binding site [chemical binding]; other site 717961003474 N-acetyl-L-glutamate binding site [chemical binding]; other site 717961003475 ornithine carbamoyltransferase; Provisional; Region: PRK00779 717961003476 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717961003477 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717961003478 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 717961003479 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 717961003480 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 717961003481 thymidylate kinase; Provisional; Region: PRK13975; cl17243 717961003482 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 717961003483 conserved cys residue [active] 717961003484 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 717961003485 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 717961003486 YceG-like family; Region: YceG; pfam02618 717961003487 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 717961003488 dimerization interface [polypeptide binding]; other site 717961003489 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 717961003490 Peptidase family U32; Region: Peptidase_U32; pfam01136 717961003491 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 717961003492 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 717961003493 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 717961003494 putative active site [active] 717961003495 putative metal binding site [ion binding]; other site 717961003496 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 717961003497 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 717961003498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 717961003499 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 717961003500 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 717961003501 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 717961003502 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 717961003503 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 717961003504 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 717961003505 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 717961003506 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 717961003507 AAA ATPase domain; Region: AAA_16; pfam13191 717961003508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961003509 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717961003510 active site 717961003511 phosphorylation site [posttranslational modification] 717961003512 intermolecular recognition site; other site 717961003513 dimerization interface [polypeptide binding]; other site 717961003514 LytTr DNA-binding domain; Region: LytTR; smart00850 717961003515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961003516 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 717961003517 ATP binding site [chemical binding]; other site 717961003518 Mg2+ binding site [ion binding]; other site 717961003519 G-X-G motif; other site 717961003520 Mannitol repressor; Region: MtlR; cl11450 717961003521 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717961003522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717961003523 active site 717961003524 Rrf2 family protein; Region: rrf2_super; TIGR00738 717961003525 Transcriptional regulator; Region: Rrf2; pfam02082 717961003526 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 717961003527 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 717961003528 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 717961003529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961003530 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 717961003531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961003532 DNA binding residues [nucleotide binding] 717961003533 DNA primase; Validated; Region: dnaG; PRK05667 717961003534 CHC2 zinc finger; Region: zf-CHC2; pfam01807 717961003535 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 717961003536 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 717961003537 active site 717961003538 metal binding site [ion binding]; metal-binding site 717961003539 interdomain interaction site; other site 717961003540 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 717961003541 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 717961003542 Protein of unknown function (DUF1423); Region: DUF1423; pfam07227 717961003543 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 717961003544 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 717961003545 active site 717961003546 (T/H)XGH motif; other site 717961003547 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 717961003548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961003549 S-adenosylmethionine binding site [chemical binding]; other site 717961003550 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 717961003551 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 717961003552 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 717961003553 V-type ATP synthase subunit I; Validated; Region: PRK05771 717961003554 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 717961003555 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 717961003556 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 717961003557 V-type ATP synthase subunit A; Provisional; Region: PRK04192 717961003558 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717961003559 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 717961003560 Walker A motif/ATP binding site; other site 717961003561 Walker B motif; other site 717961003562 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717961003563 V-type ATP synthase subunit B; Provisional; Region: PRK04196 717961003564 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717961003565 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 717961003566 Walker A motif homologous position; other site 717961003567 Walker B motif; other site 717961003568 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717961003569 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 717961003570 trehalose synthase; Region: treS_nterm; TIGR02456 717961003571 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 717961003572 active site 717961003573 catalytic site [active] 717961003574 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 717961003575 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 717961003576 Coatomer WD associated region; Region: Coatomer_WDAD; pfam04053 717961003577 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 717961003578 active site 717961003579 metal binding site [ion binding]; metal-binding site 717961003580 homotetramer interface [polypeptide binding]; other site 717961003581 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 717961003582 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 717961003583 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 717961003584 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 717961003585 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 717961003586 DNA replication protein DnaC; Validated; Region: PRK06835 717961003587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961003588 Walker A motif; other site 717961003589 ATP binding site [chemical binding]; other site 717961003590 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 717961003591 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717961003592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 717961003593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961003594 Coenzyme A binding pocket [chemical binding]; other site 717961003595 RNA methyltransferase, RsmE family; Region: TIGR00046 717961003596 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 717961003597 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 717961003598 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 717961003599 generic binding surface II; other site 717961003600 ssDNA binding site; other site 717961003601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961003602 putative Mg++ binding site [ion binding]; other site 717961003603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717961003604 nucleotide binding region [chemical binding]; other site 717961003605 ATP-binding site [chemical binding]; other site 717961003606 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 717961003607 DAK2 domain; Region: Dak2; pfam02734 717961003608 Asp23 family; Region: Asp23; cl00574 717961003609 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 717961003610 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 717961003611 hypothetical protein; Validated; Region: PRK07682 717961003612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717961003613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961003614 homodimer interface [polypeptide binding]; other site 717961003615 catalytic residue [active] 717961003616 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717961003617 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 717961003618 AsnC family; Region: AsnC_trans_reg; pfam01037 717961003619 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 717961003620 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 717961003621 active site 717961003622 isocitrate dehydrogenase; Validated; Region: PRK08299 717961003623 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 717961003624 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 717961003625 substrate binding site [chemical binding]; other site 717961003626 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 717961003627 substrate binding site [chemical binding]; other site 717961003628 ligand binding site [chemical binding]; other site 717961003629 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 717961003630 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 717961003631 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 717961003632 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 717961003633 active site 717961003634 metal binding site [ion binding]; metal-binding site 717961003635 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 717961003636 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 717961003637 GDP-binding site [chemical binding]; other site 717961003638 ACT binding site; other site 717961003639 IMP binding site; other site 717961003640 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 717961003641 Asp23 family; Region: Asp23; pfam03780 717961003642 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 717961003643 putative RNA binding site [nucleotide binding]; other site 717961003644 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 717961003645 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 717961003646 generic binding surface II; other site 717961003647 generic binding surface I; other site 717961003648 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 717961003649 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 717961003650 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 717961003651 substrate binding pocket [chemical binding]; other site 717961003652 chain length determination region; other site 717961003653 substrate-Mg2+ binding site; other site 717961003654 catalytic residues [active] 717961003655 aspartate-rich region 1; other site 717961003656 active site lid residues [active] 717961003657 aspartate-rich region 2; other site 717961003658 Divergent PAP2 family; Region: DUF212; pfam02681 717961003659 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 717961003660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961003661 RNA binding surface [nucleotide binding]; other site 717961003662 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 717961003663 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 717961003664 ATP-NAD kinase; Region: NAD_kinase; pfam01513 717961003665 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 717961003666 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 717961003667 sporulation sigma factor SigE; Reviewed; Region: PRK08301 717961003668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961003669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961003670 DNA binding residues [nucleotide binding] 717961003671 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 717961003672 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717961003673 MarR family; Region: MarR_2; pfam12802 717961003674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961003675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961003676 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 717961003677 Walker A/P-loop; other site 717961003678 ATP binding site [chemical binding]; other site 717961003679 Q-loop/lid; other site 717961003680 ABC transporter signature motif; other site 717961003681 Walker B; other site 717961003682 D-loop; other site 717961003683 H-loop/switch region; other site 717961003684 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 717961003685 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 717961003686 putative active site [active] 717961003687 Zn binding site [ion binding]; other site 717961003688 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 717961003689 Rubrerythrin [Energy production and conversion]; Region: COG1592 717961003690 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 717961003691 UDP-glucose 4-epimerase; Region: PLN02240 717961003692 NAD binding site [chemical binding]; other site 717961003693 homodimer interface [polypeptide binding]; other site 717961003694 active site 717961003695 substrate binding site [chemical binding]; other site 717961003696 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 717961003697 putative NADH binding site [chemical binding]; other site 717961003698 putative active site [active] 717961003699 nudix motif; other site 717961003700 putative metal binding site [ion binding]; other site 717961003701 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 717961003702 active site 717961003703 Melibiase; Region: Melibiase; pfam02065 717961003704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 717961003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961003706 S-adenosylmethionine binding site [chemical binding]; other site 717961003707 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 717961003708 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 717961003709 dimerization interface [polypeptide binding]; other site 717961003710 domain crossover interface; other site 717961003711 redox-dependent activation switch; other site 717961003712 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 717961003713 DHH family; Region: DHH; pfam01368 717961003714 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 717961003715 DHHA1 domain; Region: DHHA1; pfam02272 717961003716 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 717961003717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961003718 Zn2+ binding site [ion binding]; other site 717961003719 Mg2+ binding site [ion binding]; other site 717961003720 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 717961003721 synthetase active site [active] 717961003722 NTP binding site [chemical binding]; other site 717961003723 metal binding site [ion binding]; metal-binding site 717961003724 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 717961003725 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 717961003726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 717961003727 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 717961003728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961003729 FeS/SAM binding site; other site 717961003730 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 717961003731 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 717961003732 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 717961003733 active site 717961003734 prolyl-tRNA synthetase; Provisional; Region: PRK09194 717961003735 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717961003736 motif 1; other site 717961003737 dimer interface [polypeptide binding]; other site 717961003738 active site 717961003739 motif 2; other site 717961003740 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 717961003741 putative deacylase active site [active] 717961003742 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717961003743 active site 717961003744 motif 3; other site 717961003745 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 717961003746 anticodon binding site; other site 717961003747 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 717961003748 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 717961003749 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 717961003750 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 717961003751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717961003752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717961003753 dimerization interface [polypeptide binding]; other site 717961003754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717961003755 MarR family; Region: MarR_2; pfam12802 717961003756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961003757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961003758 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 717961003759 Walker A/P-loop; other site 717961003760 ATP binding site [chemical binding]; other site 717961003761 Q-loop/lid; other site 717961003762 ABC transporter signature motif; other site 717961003763 Walker B; other site 717961003764 D-loop; other site 717961003765 H-loop/switch region; other site 717961003766 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 717961003767 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 717961003768 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 717961003769 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 717961003770 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 717961003771 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 717961003772 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 717961003773 metal binding site [ion binding]; metal-binding site 717961003774 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 717961003775 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 717961003776 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 717961003777 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 717961003778 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 717961003779 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 717961003780 RPB1 interaction site [polypeptide binding]; other site 717961003781 RPB10 interaction site [polypeptide binding]; other site 717961003782 RPB11 interaction site [polypeptide binding]; other site 717961003783 RPB3 interaction site [polypeptide binding]; other site 717961003784 RPB12 interaction site [polypeptide binding]; other site 717961003785 30S ribosomal protein S7; Validated; Region: PRK05302 717961003786 elongation factor G; Reviewed; Region: PRK00007 717961003787 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 717961003788 G1 box; other site 717961003789 putative GEF interaction site [polypeptide binding]; other site 717961003790 GTP/Mg2+ binding site [chemical binding]; other site 717961003791 Switch I region; other site 717961003792 G2 box; other site 717961003793 G3 box; other site 717961003794 Switch II region; other site 717961003795 G4 box; other site 717961003796 G5 box; other site 717961003797 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 717961003798 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 717961003799 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 717961003800 elongation factor Tu; Reviewed; Region: PRK00049 717961003801 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 717961003802 G1 box; other site 717961003803 GEF interaction site [polypeptide binding]; other site 717961003804 GTP/Mg2+ binding site [chemical binding]; other site 717961003805 Switch I region; other site 717961003806 G2 box; other site 717961003807 G3 box; other site 717961003808 Switch II region; other site 717961003809 G4 box; other site 717961003810 G5 box; other site 717961003811 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 717961003812 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 717961003813 Antibiotic Binding Site [chemical binding]; other site 717961003814 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 717961003815 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 717961003816 active site 717961003817 NTP binding site [chemical binding]; other site 717961003818 metal binding triad [ion binding]; metal-binding site 717961003819 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 717961003820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 717961003821 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 717961003822 rod shape-determining protein MreB; Provisional; Region: PRK13930 717961003823 MreB and similar proteins; Region: MreB_like; cd10225 717961003824 nucleotide binding site [chemical binding]; other site 717961003825 Mg binding site [ion binding]; other site 717961003826 putative protofilament interaction site [polypeptide binding]; other site 717961003827 RodZ interaction site [polypeptide binding]; other site 717961003828 Putative esterase; Region: Esterase; pfam00756 717961003829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 717961003830 stage V sporulation protein T; Region: spore_V_T; TIGR02851 717961003831 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 717961003832 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961003833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961003834 non-specific DNA binding site [nucleotide binding]; other site 717961003835 salt bridge; other site 717961003836 sequence-specific DNA binding site [nucleotide binding]; other site 717961003837 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717961003838 catalytic core [active] 717961003839 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 717961003840 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 717961003841 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 717961003842 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 717961003843 RNA binding site [nucleotide binding]; other site 717961003844 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 717961003845 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 717961003846 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 717961003847 Cl binding site [ion binding]; other site 717961003848 oligomer interface [polypeptide binding]; other site 717961003849 Cell division protein ZapA; Region: ZapA; pfam05164 717961003850 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 717961003851 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 717961003852 Peptidase family U32; Region: Peptidase_U32; pfam01136 717961003853 Collagenase; Region: DUF3656; pfam12392 717961003854 Peptidase family U32; Region: Peptidase_U32; cl03113 717961003855 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 717961003856 trimer interface [polypeptide binding]; other site 717961003857 active site 717961003858 rod shape-determining protein MreB; Provisional; Region: PRK13927 717961003859 MreB and similar proteins; Region: MreB_like; cd10225 717961003860 nucleotide binding site [chemical binding]; other site 717961003861 Mg binding site [ion binding]; other site 717961003862 putative protofilament interaction site [polypeptide binding]; other site 717961003863 RodZ interaction site [polypeptide binding]; other site 717961003864 rod shape-determining protein MreC; Provisional; Region: PRK13922 717961003865 rod shape-determining protein MreC; Region: MreC; pfam04085 717961003866 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 717961003867 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717961003868 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 717961003869 active site 717961003870 dimer interfaces [polypeptide binding]; other site 717961003871 catalytic residues [active] 717961003872 histidyl-tRNA synthetase; Region: hisS; TIGR00442 717961003873 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 717961003874 dimer interface [polypeptide binding]; other site 717961003875 motif 1; other site 717961003876 active site 717961003877 motif 2; other site 717961003878 motif 3; other site 717961003879 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 717961003880 anticodon binding site; other site 717961003881 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 717961003882 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 717961003883 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 717961003884 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 717961003885 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 717961003886 active site 717961003887 dimer interface [polypeptide binding]; other site 717961003888 motif 1; other site 717961003889 motif 2; other site 717961003890 motif 3; other site 717961003891 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 717961003892 anticodon binding site; other site 717961003893 Putative motility protein; Region: YjfB_motility; pfam14070 717961003894 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 717961003895 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 717961003896 DNA binding residues [nucleotide binding] 717961003897 putative dimer interface [polypeptide binding]; other site 717961003898 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 717961003899 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 717961003900 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 717961003901 Tetramer interface [polypeptide binding]; other site 717961003902 active site 717961003903 FMN-binding site [chemical binding]; other site 717961003904 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 717961003905 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 717961003906 hinge; other site 717961003907 active site 717961003908 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 717961003909 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 717961003910 23S rRNA interface [nucleotide binding]; other site 717961003911 L3 interface [polypeptide binding]; other site 717961003912 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 717961003913 putative active site [active] 717961003914 dipeptidase PepV; Reviewed; Region: PRK07318 717961003915 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 717961003916 active site 717961003917 metal binding site [ion binding]; metal-binding site 717961003918 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 717961003919 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 717961003920 active site 717961003921 zinc binding site [ion binding]; other site 717961003922 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 717961003923 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717961003924 active site 717961003925 metal binding site [ion binding]; metal-binding site 717961003926 6-phosphofructokinase; Provisional; Region: PRK03202 717961003927 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 717961003928 active site 717961003929 ADP/pyrophosphate binding site [chemical binding]; other site 717961003930 dimerization interface [polypeptide binding]; other site 717961003931 allosteric effector site; other site 717961003932 fructose-1,6-bisphosphate binding site; other site 717961003933 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 717961003934 N- and C-terminal domain interface [polypeptide binding]; other site 717961003935 D-xylulose kinase; Region: XylB; TIGR01312 717961003936 active site 717961003937 MgATP binding site [chemical binding]; other site 717961003938 catalytic site [active] 717961003939 metal binding site [ion binding]; metal-binding site 717961003940 xylulose binding site [chemical binding]; other site 717961003941 homodimer interface [polypeptide binding]; other site 717961003942 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 717961003943 active site 717961003944 intersubunit interactions; other site 717961003945 catalytic residue [active] 717961003946 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 717961003947 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 717961003948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717961003949 active site 717961003950 recombination factor protein RarA; Reviewed; Region: PRK13342 717961003951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961003952 Walker A motif; other site 717961003953 ATP binding site [chemical binding]; other site 717961003954 Walker B motif; other site 717961003955 arginine finger; other site 717961003956 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 717961003957 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717961003958 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717961003959 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 717961003960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961003961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961003962 non-specific DNA binding site [nucleotide binding]; other site 717961003963 salt bridge; other site 717961003964 sequence-specific DNA binding site [nucleotide binding]; other site 717961003965 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 717961003966 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 717961003967 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 717961003968 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 717961003969 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 717961003970 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 717961003971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 717961003972 nucleotide binding site [chemical binding]; other site 717961003973 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 717961003974 hypothetical protein; Reviewed; Region: PRK00024 717961003975 Helix-hairpin-helix motif; Region: HHH; pfam00633 717961003976 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 717961003977 MPN+ (JAMM) motif; other site 717961003978 Zinc-binding site [ion binding]; other site 717961003979 excinuclease ABC subunit B; Provisional; Region: PRK05298 717961003980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961003981 ATP binding site [chemical binding]; other site 717961003982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717961003983 nucleotide binding region [chemical binding]; other site 717961003984 ATP-binding site [chemical binding]; other site 717961003985 Ultra-violet resistance protein B; Region: UvrB; pfam12344 717961003986 UvrB/uvrC motif; Region: UVR; pfam02151 717961003987 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 717961003988 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 717961003989 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 717961003990 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 717961003991 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 717961003992 GGGtGRT protein; Region: GGGtGRT; pfam14057 717961003993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961003994 AAA domain; Region: AAA_21; pfam13304 717961003995 Walker A/P-loop; other site 717961003996 ATP binding site [chemical binding]; other site 717961003997 RloB-like protein; Region: RloB; pfam13707 717961003998 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 717961003999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961004000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961004001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961004002 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 717961004003 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 717961004004 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 717961004005 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 717961004006 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 717961004007 PYR/PP interface [polypeptide binding]; other site 717961004008 TPP binding site [chemical binding]; other site 717961004009 dimer interface [polypeptide binding]; other site 717961004010 substrate binding site [chemical binding]; other site 717961004011 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 717961004012 TPP-binding site; other site 717961004013 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 717961004014 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 717961004015 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 717961004016 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717961004017 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 717961004018 acyl-activating enzyme (AAE) consensus motif; other site 717961004019 AMP binding site [chemical binding]; other site 717961004020 active site 717961004021 CoA binding site [chemical binding]; other site 717961004022 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 717961004023 active site 717961004024 catalytic triad [active] 717961004025 oxyanion hole [active] 717961004026 alanine racemase; Reviewed; Region: alr; PRK00053 717961004027 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 717961004028 active site 717961004029 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717961004030 dimer interface [polypeptide binding]; other site 717961004031 substrate binding site [chemical binding]; other site 717961004032 catalytic residues [active] 717961004033 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 717961004034 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961004035 active site 717961004036 DNA binding site [nucleotide binding] 717961004037 Int/Topo IB signature motif; other site 717961004038 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717961004039 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717961004040 P-loop; other site 717961004041 Magnesium ion binding site [ion binding]; other site 717961004042 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717961004043 Magnesium ion binding site [ion binding]; other site 717961004044 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717961004045 ParB-like nuclease domain; Region: ParBc; pfam02195 717961004046 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 717961004047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961004048 S-adenosylmethionine binding site [chemical binding]; other site 717961004049 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 717961004050 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 717961004051 DEAD-like helicases superfamily; Region: DEXDc; smart00487 717961004052 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 717961004053 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717961004054 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 717961004055 putative catalytic residues [active] 717961004056 catalytic nucleophile [active] 717961004057 Recombinase; Region: Recombinase; pfam07508 717961004058 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717961004059 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 717961004060 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 717961004061 Putative transposase; Region: Y2_Tnp; pfam04986 717961004062 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 717961004063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961004064 active site 717961004065 DNA binding site [nucleotide binding] 717961004066 Int/Topo IB signature motif; other site 717961004067 SnoaL-like domain; Region: SnoaL_2; pfam12680 717961004068 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 717961004069 AAA domain; Region: AAA_25; pfam13481 717961004070 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717961004071 Walker A motif; other site 717961004072 ATP binding site [chemical binding]; other site 717961004073 Walker B motif; other site 717961004074 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 717961004075 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 717961004076 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 717961004077 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717961004078 ParB-like nuclease domain; Region: ParBc; pfam02195 717961004079 Protein of unknown function (DUF3848); Region: DUF3848; pfam12959 717961004080 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961004081 SpoVG; Region: SpoVG; cl00915 717961004082 AAA-like domain; Region: AAA_10; pfam12846 717961004083 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717961004084 Walker A motif; other site 717961004085 ATP binding site [chemical binding]; other site 717961004086 Walker B motif; other site 717961004087 hypothetical protein; Provisional; Region: PRK08126 717961004088 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 717961004089 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 717961004090 AAA-like domain; Region: AAA_10; pfam12846 717961004091 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 717961004092 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 717961004093 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 717961004094 active site 717961004095 metal binding site [ion binding]; metal-binding site 717961004096 interdomain interaction site; other site 717961004097 Helix-turn-helix domain; Region: HTH_36; pfam13730 717961004098 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717961004099 Helix-turn-helix domain; Region: HTH_36; pfam13730 717961004100 TIR domain; Region: TIR_2; pfam13676 717961004101 MoxR-like ATPases [General function prediction only]; Region: COG0714 717961004102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 717961004103 Walker B motif; other site 717961004104 arginine finger; other site 717961004105 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 717961004106 Protein of unknown function DUF58; Region: DUF58; pfam01882 717961004107 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 717961004108 MoxR-like ATPases [General function prediction only]; Region: COG0714 717961004109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004110 Walker A motif; other site 717961004111 ATP binding site [chemical binding]; other site 717961004112 Walker B motif; other site 717961004113 arginine finger; other site 717961004114 Protein of unknown function DUF58; Region: DUF58; pfam01882 717961004115 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 717961004116 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 717961004117 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717961004118 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 717961004119 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 717961004120 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717961004121 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 717961004122 active site 717961004123 catalytic residues [active] 717961004124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961004125 Coenzyme A binding pocket [chemical binding]; other site 717961004126 FOG: CBS domain [General function prediction only]; Region: COG0517 717961004127 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717961004128 Transporter associated domain; Region: CorC_HlyC; pfam03471 717961004129 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 717961004130 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 717961004131 active site 717961004132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 717961004133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 717961004134 DNA binding site [nucleotide binding] 717961004135 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 717961004136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 717961004137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 717961004138 DNA binding site [nucleotide binding] 717961004139 domain linker motif; other site 717961004140 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 717961004141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717961004142 dimer interface [polypeptide binding]; other site 717961004143 phosphorylation site [posttranslational modification] 717961004144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961004145 ATP binding site [chemical binding]; other site 717961004146 Mg2+ binding site [ion binding]; other site 717961004147 G-X-G motif; other site 717961004148 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 717961004149 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 717961004150 trimer interface [polypeptide binding]; other site 717961004151 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 717961004152 ApbE family; Region: ApbE; pfam02424 717961004153 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 717961004154 active site 717961004155 putative DNA-binding cleft [nucleotide binding]; other site 717961004156 dimer interface [polypeptide binding]; other site 717961004157 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 717961004158 RuvA N terminal domain; Region: RuvA_N; pfam01330 717961004159 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 717961004160 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 717961004161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004162 Walker A motif; other site 717961004163 ATP binding site [chemical binding]; other site 717961004164 Walker B motif; other site 717961004165 arginine finger; other site 717961004166 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 717961004167 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 717961004168 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 717961004169 Walker A/P-loop; other site 717961004170 ATP binding site [chemical binding]; other site 717961004171 Q-loop/lid; other site 717961004172 ABC transporter signature motif; other site 717961004173 Walker B; other site 717961004174 D-loop; other site 717961004175 H-loop/switch region; other site 717961004176 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 717961004177 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 717961004178 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 717961004179 dimerization interface 3.5A [polypeptide binding]; other site 717961004180 active site 717961004181 PQQ-like domain; Region: PQQ_2; pfam13360 717961004182 Colicin V production protein; Region: Colicin_V; pfam02674 717961004183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004184 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 717961004185 Walker A motif; other site 717961004186 ATP binding site [chemical binding]; other site 717961004187 Walker B motif; other site 717961004188 arginine finger; other site 717961004189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004190 Walker A motif; other site 717961004191 ATP binding site [chemical binding]; other site 717961004192 Walker B motif; other site 717961004193 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 717961004194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717961004195 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717961004196 NAD(P) binding site [chemical binding]; other site 717961004197 active site 717961004198 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 717961004199 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 717961004200 G1 box; other site 717961004201 GTP/Mg2+ binding site [chemical binding]; other site 717961004202 G2 box; other site 717961004203 Switch I region; other site 717961004204 G3 box; other site 717961004205 Switch II region; other site 717961004206 G4 box; other site 717961004207 G5 box; other site 717961004208 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 717961004209 nudix motif; other site 717961004210 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 717961004211 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 717961004212 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 717961004213 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 717961004214 dimer interface [polypeptide binding]; other site 717961004215 ssDNA binding site [nucleotide binding]; other site 717961004216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717961004217 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 717961004218 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717961004219 active site 717961004220 catalytic triad [active] 717961004221 oxyanion hole [active] 717961004222 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 717961004223 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 717961004224 ATP cone domain; Region: ATP-cone; pfam03477 717961004225 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717961004226 Class III ribonucleotide reductase; Region: RNR_III; cd01675 717961004227 active site 717961004228 Zn binding site [ion binding]; other site 717961004229 glycine loop; other site 717961004230 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 717961004231 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717961004232 classical (c) SDRs; Region: SDR_c; cd05233 717961004233 NAD(P) binding site [chemical binding]; other site 717961004234 active site 717961004235 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 717961004236 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 717961004237 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 717961004238 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 717961004239 dimer interface [polypeptide binding]; other site 717961004240 anticodon binding site; other site 717961004241 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 717961004242 homodimer interface [polypeptide binding]; other site 717961004243 motif 1; other site 717961004244 active site 717961004245 motif 2; other site 717961004246 GAD domain; Region: GAD; pfam02938 717961004247 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717961004248 active site 717961004249 motif 3; other site 717961004250 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 717961004251 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717961004252 Walker A motif; other site 717961004253 ATP binding site [chemical binding]; other site 717961004254 Walker B motif; other site 717961004255 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 717961004256 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 717961004257 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 717961004258 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 717961004259 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 717961004260 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 717961004261 transmembrane helices; other site 717961004262 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 717961004263 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 717961004264 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 717961004265 Tim44-like domain; Region: Tim44; cl09208 717961004266 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 717961004267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717961004268 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 717961004269 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 717961004270 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717961004271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717961004272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004273 Walker A/P-loop; other site 717961004274 ATP binding site [chemical binding]; other site 717961004275 Q-loop/lid; other site 717961004276 ABC transporter signature motif; other site 717961004277 Walker B; other site 717961004278 D-loop; other site 717961004279 H-loop/switch region; other site 717961004280 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717961004281 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717961004282 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717961004283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717961004284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961004285 active site 717961004286 phosphorylation site [posttranslational modification] 717961004287 intermolecular recognition site; other site 717961004288 dimerization interface [polypeptide binding]; other site 717961004289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717961004290 DNA binding residues [nucleotide binding] 717961004291 dimerization interface [polypeptide binding]; other site 717961004292 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 717961004293 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 717961004294 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 717961004295 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 717961004296 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717961004297 active site 717961004298 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 717961004299 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 717961004300 YabP family; Region: YabP; pfam07873 717961004301 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 717961004302 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 717961004303 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 717961004304 PhoH-like protein; Region: PhoH; pfam02562 717961004305 metal-binding heat shock protein; Provisional; Region: PRK00016 717961004306 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 717961004307 GTPase Era; Reviewed; Region: era; PRK00089 717961004308 G1 box; other site 717961004309 GTP/Mg2+ binding site [chemical binding]; other site 717961004310 Switch I region; other site 717961004311 G2 box; other site 717961004312 Switch II region; other site 717961004313 G3 box; other site 717961004314 G4 box; other site 717961004315 G5 box; other site 717961004316 KH domain; Region: KH_2; pfam07650 717961004317 Recombination protein O N terminal; Region: RecO_N; pfam11967 717961004318 DNA repair protein RecO; Region: reco; TIGR00613 717961004319 Recombination protein O C terminal; Region: RecO_C; pfam02565 717961004320 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 717961004321 MutS domain III; Region: MutS_III; pfam05192 717961004322 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 717961004323 Walker A/P-loop; other site 717961004324 ATP binding site [chemical binding]; other site 717961004325 Q-loop/lid; other site 717961004326 ABC transporter signature motif; other site 717961004327 Walker B; other site 717961004328 D-loop; other site 717961004329 H-loop/switch region; other site 717961004330 Smr domain; Region: Smr; pfam01713 717961004331 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 717961004332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961004333 motif II; other site 717961004334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717961004335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717961004336 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 717961004337 dimerization interface [polypeptide binding]; other site 717961004338 putative active cleft [active] 717961004339 Uncharacterized conserved protein [Function unknown]; Region: COG4198 717961004340 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 717961004341 Late competence development protein ComFB; Region: ComFB; pfam10719 717961004342 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 717961004343 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 717961004344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961004345 FeS/SAM binding site; other site 717961004346 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 717961004347 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 717961004348 putative deacylase active site [active] 717961004349 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 717961004350 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 717961004351 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 717961004352 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 717961004353 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 717961004354 intersubunit interface [polypeptide binding]; other site 717961004355 active site 717961004356 zinc binding site [ion binding]; other site 717961004357 Na+ binding site [ion binding]; other site 717961004358 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 717961004359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961004360 active site 717961004361 DNA binding site [nucleotide binding] 717961004362 Int/Topo IB signature motif; other site 717961004363 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 717961004364 Low molecular weight phosphatase family; Region: LMWPc; cd00115 717961004365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961004366 Coenzyme A binding pocket [chemical binding]; other site 717961004367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961004368 Coenzyme A binding pocket [chemical binding]; other site 717961004369 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 717961004370 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 717961004371 G1 box; other site 717961004372 GTP/Mg2+ binding site [chemical binding]; other site 717961004373 Switch I region; other site 717961004374 G2 box; other site 717961004375 G3 box; other site 717961004376 Switch II region; other site 717961004377 G4 box; other site 717961004378 G5 box; other site 717961004379 Nucleoside recognition; Region: Gate; pfam07670 717961004380 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 717961004381 Nucleoside recognition; Region: Gate; pfam07670 717961004382 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961004383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961004384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004385 Walker A/P-loop; other site 717961004386 ATP binding site [chemical binding]; other site 717961004387 Q-loop/lid; other site 717961004388 ABC transporter signature motif; other site 717961004389 Walker B; other site 717961004390 D-loop; other site 717961004391 H-loop/switch region; other site 717961004392 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961004393 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961004394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004395 Walker A/P-loop; other site 717961004396 ATP binding site [chemical binding]; other site 717961004397 Q-loop/lid; other site 717961004398 ABC transporter signature motif; other site 717961004399 Walker B; other site 717961004400 D-loop; other site 717961004401 H-loop/switch region; other site 717961004402 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961004403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961004404 non-specific DNA binding site [nucleotide binding]; other site 717961004405 salt bridge; other site 717961004406 sequence-specific DNA binding site [nucleotide binding]; other site 717961004407 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 717961004408 Maf-like protein; Region: Maf; pfam02545 717961004409 active site 717961004410 dimer interface [polypeptide binding]; other site 717961004411 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 717961004412 dimer interface [polypeptide binding]; other site 717961004413 substrate binding site [chemical binding]; other site 717961004414 metal binding sites [ion binding]; metal-binding site 717961004415 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961004416 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 717961004417 Septum formation initiator; Region: DivIC; pfam04977 717961004418 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 717961004419 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 717961004420 YabP family; Region: YabP; cl06766 717961004421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961004422 RNA binding surface [nucleotide binding]; other site 717961004423 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 717961004424 IHF dimer interface [polypeptide binding]; other site 717961004425 IHF - DNA interface [nucleotide binding]; other site 717961004426 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 717961004427 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 717961004428 HemN C-terminal domain; Region: HemN_C; pfam06969 717961004429 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 717961004430 homodimer interface [polypeptide binding]; other site 717961004431 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 717961004432 active site pocket [active] 717961004433 Predicted peptidase [General function prediction only]; Region: COG4099 717961004434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717961004435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 717961004436 active site 717961004437 metal binding site [ion binding]; metal-binding site 717961004438 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 717961004439 active site 717961004440 NTP binding site [chemical binding]; other site 717961004441 metal binding triad [ion binding]; metal-binding site 717961004442 Homoserine O-succinyltransferase; Region: HTS; pfam04204 717961004443 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 717961004444 proposed active site lysine [active] 717961004445 conserved cys residue [active] 717961004446 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 717961004447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961004448 motif II; other site 717961004449 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 717961004450 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 717961004451 active site 717961004452 catalytic site [active] 717961004453 DRTGG domain; Region: DRTGG; pfam07085 717961004454 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 717961004455 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 717961004456 putative dimer interface [polypeptide binding]; other site 717961004457 [2Fe-2S] cluster binding site [ion binding]; other site 717961004458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961004459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961004460 ATP binding site [chemical binding]; other site 717961004461 Mg2+ binding site [ion binding]; other site 717961004462 G-X-G motif; other site 717961004463 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 717961004464 dimer interface [polypeptide binding]; other site 717961004465 [2Fe-2S] cluster binding site [ion binding]; other site 717961004466 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 717961004467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717961004468 catalytic loop [active] 717961004469 iron binding site [ion binding]; other site 717961004470 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 717961004471 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 717961004472 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 717961004473 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 717961004474 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 717961004475 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 717961004476 2-isopropylmalate synthase; Validated; Region: PRK03739 717961004477 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 717961004478 active site 717961004479 catalytic residues [active] 717961004480 metal binding site [ion binding]; metal-binding site 717961004481 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 717961004482 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 717961004483 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 717961004484 nucleotide binding pocket [chemical binding]; other site 717961004485 K-X-D-G motif; other site 717961004486 catalytic site [active] 717961004487 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 717961004488 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 717961004489 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 717961004490 DNA binding site [nucleotide binding] 717961004491 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 717961004492 Dimer interface [polypeptide binding]; other site 717961004493 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 717961004494 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 717961004495 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 717961004496 oligomer interface [polypeptide binding]; other site 717961004497 putative active site [active] 717961004498 metal binding site [ion binding]; metal-binding site 717961004499 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 717961004500 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 717961004501 N-acetyl-D-glucosamine binding site [chemical binding]; other site 717961004502 catalytic residue [active] 717961004503 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 717961004504 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 717961004505 CoA-binding site [chemical binding]; other site 717961004506 ATP-binding [chemical binding]; other site 717961004507 peptide chain release factor 1; Validated; Region: prfA; PRK00591 717961004508 PCRF domain; Region: PCRF; pfam03462 717961004509 RF-1 domain; Region: RF-1; pfam00472 717961004510 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 717961004511 Cache domain; Region: Cache_1; pfam02743 717961004512 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717961004513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717961004514 dimerization interface [polypeptide binding]; other site 717961004515 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961004516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961004517 metal binding site [ion binding]; metal-binding site 717961004518 active site 717961004519 I-site; other site 717961004520 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 717961004521 Clp amino terminal domain; Region: Clp_N; pfam02861 717961004522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004523 Walker A motif; other site 717961004524 ATP binding site [chemical binding]; other site 717961004525 Walker B motif; other site 717961004526 arginine finger; other site 717961004527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004528 Walker A motif; other site 717961004529 ATP binding site [chemical binding]; other site 717961004530 Walker B motif; other site 717961004531 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717961004532 Domain of unknown function (DUF378); Region: DUF378; pfam04070 717961004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004534 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 717961004535 Walker A/P-loop; other site 717961004536 ATP binding site [chemical binding]; other site 717961004537 Q-loop/lid; other site 717961004538 ABC transporter signature motif; other site 717961004539 Walker B; other site 717961004540 D-loop; other site 717961004541 H-loop/switch region; other site 717961004542 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 717961004543 FMN binding site [chemical binding]; other site 717961004544 dimer interface [polypeptide binding]; other site 717961004545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961004546 Coenzyme A binding pocket [chemical binding]; other site 717961004547 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961004548 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 717961004549 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 717961004550 active site 717961004551 Isochorismatase family; Region: Isochorismatase; pfam00857 717961004552 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717961004553 catalytic triad [active] 717961004554 conserved cis-peptide bond; other site 717961004555 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 717961004556 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 717961004557 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 717961004558 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 717961004559 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 717961004560 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 717961004561 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 717961004562 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 717961004563 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 717961004564 Bacitracin resistance protein BacA; Region: BacA; pfam02673 717961004565 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 717961004566 active site 717961004567 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 717961004568 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 717961004569 RNase E interface [polypeptide binding]; other site 717961004570 trimer interface [polypeptide binding]; other site 717961004571 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 717961004572 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 717961004573 RNase E interface [polypeptide binding]; other site 717961004574 trimer interface [polypeptide binding]; other site 717961004575 active site 717961004576 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 717961004577 putative nucleic acid binding region [nucleotide binding]; other site 717961004578 G-X-X-G motif; other site 717961004579 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 717961004580 RNA binding site [nucleotide binding]; other site 717961004581 domain interface; other site 717961004582 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 717961004583 16S/18S rRNA binding site [nucleotide binding]; other site 717961004584 S13e-L30e interaction site [polypeptide binding]; other site 717961004585 25S rRNA binding site [nucleotide binding]; other site 717961004586 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 717961004587 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 717961004588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004589 Walker A motif; other site 717961004590 ATP binding site [chemical binding]; other site 717961004591 Walker B motif; other site 717961004592 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 717961004593 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 717961004594 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 717961004595 oligomer interface [polypeptide binding]; other site 717961004596 active site residues [active] 717961004597 trigger factor; Provisional; Region: tig; PRK01490 717961004598 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 717961004599 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 717961004600 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717961004601 active site 717961004602 metal binding site [ion binding]; metal-binding site 717961004603 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717961004604 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 717961004605 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 717961004606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961004607 catalytic residue [active] 717961004608 hypothetical protein; Reviewed; Region: PRK12497 717961004609 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 717961004610 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 717961004611 GTP/Mg2+ binding site [chemical binding]; other site 717961004612 G4 box; other site 717961004613 G5 box; other site 717961004614 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 717961004615 G1 box; other site 717961004616 Switch I region; other site 717961004617 G2 box; other site 717961004618 G3 box; other site 717961004619 Switch II region; other site 717961004620 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 717961004621 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 717961004622 Catalytic site [active] 717961004623 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 717961004624 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 717961004625 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 717961004626 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 717961004627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961004628 FeS/SAM binding site; other site 717961004629 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 717961004630 four helix bundle protein; Region: TIGR02436 717961004631 Thiamine pyrophosphokinase; Region: TPK; cd07995 717961004632 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 717961004633 active site 717961004634 dimerization interface [polypeptide binding]; other site 717961004635 thiamine binding site [chemical binding]; other site 717961004636 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717961004637 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 717961004638 active site 717961004639 ATP binding site [chemical binding]; other site 717961004640 substrate binding site [chemical binding]; other site 717961004641 activation loop (A-loop); other site 717961004642 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 717961004643 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 717961004644 Protein phosphatase 2C; Region: PP2C; pfam00481 717961004645 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 717961004646 active site 717961004647 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 717961004648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961004649 FeS/SAM binding site; other site 717961004650 16S rRNA methyltransferase B; Provisional; Region: PRK14902 717961004651 NusB family; Region: NusB; pfam01029 717961004652 putative RNA binding site [nucleotide binding]; other site 717961004653 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 717961004654 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 717961004655 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 717961004656 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 717961004657 putative active site [active] 717961004658 substrate binding site [chemical binding]; other site 717961004659 putative cosubstrate binding site; other site 717961004660 catalytic site [active] 717961004661 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 717961004662 substrate binding site [chemical binding]; other site 717961004663 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 717961004664 active site 717961004665 catalytic residues [active] 717961004666 metal binding site [ion binding]; metal-binding site 717961004667 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 717961004668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961004669 ATP binding site [chemical binding]; other site 717961004670 putative Mg++ binding site [ion binding]; other site 717961004671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717961004672 ATP-binding site [chemical binding]; other site 717961004673 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 717961004674 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 717961004675 catalytic site [active] 717961004676 G-X2-G-X-G-K; other site 717961004677 Domain of unknown function (DUF370); Region: DUF370; cl00898 717961004678 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 717961004679 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 717961004680 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717961004681 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 717961004682 active site 717961004683 metal binding site [ion binding]; metal-binding site 717961004684 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 717961004685 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 717961004686 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717961004687 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 717961004688 dimer interface [polypeptide binding]; other site 717961004689 active site 717961004690 catalytic residue [active] 717961004691 dihydrodipicolinate reductase; Provisional; Region: PRK00048 717961004692 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 717961004693 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 717961004694 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 717961004695 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 717961004696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961004697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961004698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004699 Walker A/P-loop; other site 717961004700 ATP binding site [chemical binding]; other site 717961004701 Q-loop/lid; other site 717961004702 ABC transporter signature motif; other site 717961004703 Walker B; other site 717961004704 D-loop; other site 717961004705 H-loop/switch region; other site 717961004706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961004707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961004708 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 717961004709 Walker A/P-loop; other site 717961004710 ATP binding site [chemical binding]; other site 717961004711 Q-loop/lid; other site 717961004712 ABC transporter signature motif; other site 717961004713 Walker B; other site 717961004714 D-loop; other site 717961004715 H-loop/switch region; other site 717961004716 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 717961004717 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717961004718 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 717961004719 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717961004720 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 717961004721 active site 717961004722 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961004723 Interdomain contacts; other site 717961004724 Cytokine receptor motif; other site 717961004725 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961004726 Interdomain contacts; other site 717961004727 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961004728 Interdomain contacts; other site 717961004729 Cytokine receptor motif; other site 717961004730 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961004731 Interdomain contacts; other site 717961004732 Cytokine receptor motif; other site 717961004733 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 717961004734 30S subunit binding site; other site 717961004735 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 717961004736 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 717961004737 NAD-dependent deacetylase; Provisional; Region: PRK00481 717961004738 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 717961004739 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 717961004740 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 717961004741 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 717961004742 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717961004743 homotrimer interaction site [polypeptide binding]; other site 717961004744 putative active site [active] 717961004745 threonine dehydratase; Provisional; Region: PRK08198 717961004746 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 717961004747 tetramer interface [polypeptide binding]; other site 717961004748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961004749 catalytic residue [active] 717961004750 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 717961004751 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 717961004752 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 717961004753 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 717961004754 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 717961004755 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 717961004756 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 717961004757 TSCPD domain; Region: TSCPD; cl14834 717961004758 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 717961004759 Malic enzyme, N-terminal domain; Region: malic; pfam00390 717961004760 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 717961004761 putative NAD(P) binding site [chemical binding]; other site 717961004762 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 717961004763 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 717961004764 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 717961004765 active site 717961004766 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 717961004767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961004768 Walker A motif; other site 717961004769 ATP binding site [chemical binding]; other site 717961004770 Walker B motif; other site 717961004771 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 717961004772 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 717961004773 intersubunit interface [polypeptide binding]; other site 717961004774 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 717961004775 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 717961004776 motif 1; other site 717961004777 active site 717961004778 motif 2; other site 717961004779 motif 3; other site 717961004780 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 717961004781 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 717961004782 nucleotide binding site/active site [active] 717961004783 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 717961004784 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 717961004785 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 717961004786 DHHW protein; Region: DHHW; pfam14286 717961004787 DHHW protein; Region: DHHW; pfam14286 717961004788 Domain of unknown function (DUF305); Region: DUF305; pfam03713 717961004789 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 717961004790 Beta-lactamase; Region: Beta-lactamase; pfam00144 717961004791 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717961004792 metal binding site 2 [ion binding]; metal-binding site 717961004793 putative DNA binding helix; other site 717961004794 metal binding site 1 [ion binding]; metal-binding site 717961004795 dimer interface [polypeptide binding]; other site 717961004796 structural Zn2+ binding site [ion binding]; other site 717961004797 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 717961004798 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 717961004799 intersubunit interface [polypeptide binding]; other site 717961004800 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 717961004801 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 717961004802 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 717961004803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 717961004804 ABC-ATPase subunit interface; other site 717961004805 dimer interface [polypeptide binding]; other site 717961004806 putative PBP binding regions; other site 717961004807 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961004808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961004809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961004810 DNA binding residues [nucleotide binding] 717961004811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961004812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961004813 metal binding site [ion binding]; metal-binding site 717961004814 active site 717961004815 I-site; other site 717961004816 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717961004817 TspO/MBR family; Region: TspO_MBR; pfam03073 717961004818 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 717961004819 Predicted membrane protein [Function unknown]; Region: COG3601 717961004820 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 717961004821 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 717961004822 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 717961004823 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 717961004824 active site 717961004825 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 717961004826 mRNA/rRNA interface [nucleotide binding]; other site 717961004827 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 717961004828 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 717961004829 23S rRNA interface [nucleotide binding]; other site 717961004830 L7/L12 interface [polypeptide binding]; other site 717961004831 putative thiostrepton binding site; other site 717961004832 L25 interface [polypeptide binding]; other site 717961004833 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 717961004834 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 717961004835 putative homodimer interface [polypeptide binding]; other site 717961004836 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 717961004837 heterodimer interface [polypeptide binding]; other site 717961004838 homodimer interface [polypeptide binding]; other site 717961004839 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 717961004840 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 717961004841 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 717961004842 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 717961004843 homodimer interface [polypeptide binding]; other site 717961004844 NADP binding site [chemical binding]; other site 717961004845 substrate binding site [chemical binding]; other site 717961004846 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 717961004847 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717961004848 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717961004849 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717961004850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717961004851 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717961004852 GTP-binding protein YchF; Reviewed; Region: PRK09601 717961004853 YchF GTPase; Region: YchF; cd01900 717961004854 G1 box; other site 717961004855 GTP/Mg2+ binding site [chemical binding]; other site 717961004856 Switch I region; other site 717961004857 G2 box; other site 717961004858 Switch II region; other site 717961004859 G3 box; other site 717961004860 G4 box; other site 717961004861 G5 box; other site 717961004862 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 717961004863 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 717961004864 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 717961004865 Protein of unknown function (DUF464); Region: DUF464; pfam04327 717961004866 GTPase CgtA; Reviewed; Region: obgE; PRK12297 717961004867 GTP1/OBG; Region: GTP1_OBG; pfam01018 717961004868 Obg GTPase; Region: Obg; cd01898 717961004869 G1 box; other site 717961004870 GTP/Mg2+ binding site [chemical binding]; other site 717961004871 Switch I region; other site 717961004872 G2 box; other site 717961004873 G3 box; other site 717961004874 Switch II region; other site 717961004875 G4 box; other site 717961004876 G5 box; other site 717961004877 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 717961004878 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 717961004879 active site 717961004880 metal binding site [ion binding]; metal-binding site 717961004881 dimerization interface [polypeptide binding]; other site 717961004882 Uncharacterized conserved protein [Function unknown]; Region: COG1284 717961004883 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 717961004884 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 717961004885 hypothetical protein; Validated; Region: PRK00110 717961004886 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 717961004887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 717961004888 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961004889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961004890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961004891 Coenzyme A binding pocket [chemical binding]; other site 717961004892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717961004893 Radical SAM superfamily; Region: Radical_SAM; pfam04055 717961004894 FeS/SAM binding site; other site 717961004895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961004896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961004897 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 717961004898 Walker A/P-loop; other site 717961004899 ATP binding site [chemical binding]; other site 717961004900 Q-loop/lid; other site 717961004901 ABC transporter signature motif; other site 717961004902 Walker B; other site 717961004903 D-loop; other site 717961004904 H-loop/switch region; other site 717961004905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961004906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961004907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004908 Walker A/P-loop; other site 717961004909 ATP binding site [chemical binding]; other site 717961004910 Q-loop/lid; other site 717961004911 ABC transporter signature motif; other site 717961004912 Walker B; other site 717961004913 D-loop; other site 717961004914 H-loop/switch region; other site 717961004915 prephenate dehydrogenase; Validated; Region: PRK08507 717961004916 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 717961004917 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 717961004918 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 717961004919 LytTr DNA-binding domain; Region: LytTR; smart00850 717961004920 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 717961004921 conserved cys residue [active] 717961004922 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 717961004923 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717961004924 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 717961004925 L-fucose isomerase; Provisional; Region: fucI; PRK10991 717961004926 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 717961004927 hexamer (dimer of trimers) interface [polypeptide binding]; other site 717961004928 trimer interface [polypeptide binding]; other site 717961004929 substrate binding site [chemical binding]; other site 717961004930 Mn binding site [ion binding]; other site 717961004931 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 717961004932 N- and C-terminal domain interface [polypeptide binding]; other site 717961004933 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 717961004934 active site 717961004935 putative catalytic site [active] 717961004936 metal binding site [ion binding]; metal-binding site 717961004937 ATP binding site [chemical binding]; other site 717961004938 carbohydrate binding site [chemical binding]; other site 717961004939 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 717961004940 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 717961004941 intersubunit interface [polypeptide binding]; other site 717961004942 active site 717961004943 Zn2+ binding site [ion binding]; other site 717961004944 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 717961004945 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 717961004946 dimer interface [polypeptide binding]; other site 717961004947 active site 717961004948 metal binding site [ion binding]; metal-binding site 717961004949 elongation factor Ts; Provisional; Region: tsf; PRK09377 717961004950 UBA/TS-N domain; Region: UBA; pfam00627 717961004951 Elongation factor TS; Region: EF_TS; pfam00889 717961004952 Elongation factor TS; Region: EF_TS; pfam00889 717961004953 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 717961004954 rRNA interaction site [nucleotide binding]; other site 717961004955 S8 interaction site; other site 717961004956 putative laminin-1 binding site; other site 717961004957 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 717961004958 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717961004959 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717961004960 TM-ABC transporter signature motif; other site 717961004961 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 717961004962 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717961004963 TM-ABC transporter signature motif; other site 717961004964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 717961004965 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 717961004966 Walker A/P-loop; other site 717961004967 ATP binding site [chemical binding]; other site 717961004968 Q-loop/lid; other site 717961004969 ABC transporter signature motif; other site 717961004970 Walker B; other site 717961004971 D-loop; other site 717961004972 H-loop/switch region; other site 717961004973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 717961004974 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 717961004975 Walker A/P-loop; other site 717961004976 ATP binding site [chemical binding]; other site 717961004977 Q-loop/lid; other site 717961004978 ABC transporter signature motif; other site 717961004979 Walker B; other site 717961004980 D-loop; other site 717961004981 H-loop/switch region; other site 717961004982 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 717961004983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961004984 Zn2+ binding site [ion binding]; other site 717961004985 Mg2+ binding site [ion binding]; other site 717961004986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961004987 Walker A/P-loop; other site 717961004988 ATP binding site [chemical binding]; other site 717961004989 Q-loop/lid; other site 717961004990 ABC transporter signature motif; other site 717961004991 Walker B; other site 717961004992 D-loop; other site 717961004993 H-loop/switch region; other site 717961004994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717961004995 classical (c) SDRs; Region: SDR_c; cd05233 717961004996 NAD(P) binding site [chemical binding]; other site 717961004997 active site 717961004998 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 717961004999 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961005000 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 717961005001 metal binding site [ion binding]; metal-binding site 717961005002 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 717961005003 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 717961005004 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 717961005005 substrate binding site [chemical binding]; other site 717961005006 glutamase interaction surface [polypeptide binding]; other site 717961005007 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 717961005008 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 717961005009 catalytic residues [active] 717961005010 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 717961005011 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 717961005012 putative active site [active] 717961005013 oxyanion strand; other site 717961005014 catalytic triad [active] 717961005015 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 717961005016 putative active site pocket [active] 717961005017 4-fold oligomerization interface [polypeptide binding]; other site 717961005018 metal binding residues [ion binding]; metal-binding site 717961005019 3-fold/trimer interface [polypeptide binding]; other site 717961005020 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 717961005021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717961005022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961005023 homodimer interface [polypeptide binding]; other site 717961005024 catalytic residue [active] 717961005025 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 717961005026 histidinol dehydrogenase; Region: hisD; TIGR00069 717961005027 NAD binding site [chemical binding]; other site 717961005028 dimerization interface [polypeptide binding]; other site 717961005029 product binding site; other site 717961005030 substrate binding site [chemical binding]; other site 717961005031 zinc binding site [ion binding]; other site 717961005032 catalytic residues [active] 717961005033 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 717961005034 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 717961005035 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 717961005036 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 717961005037 dimer interface [polypeptide binding]; other site 717961005038 motif 1; other site 717961005039 active site 717961005040 motif 2; other site 717961005041 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 717961005042 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717961005043 hypothetical protein; Provisional; Region: PRK13670 717961005044 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 717961005045 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 717961005046 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 717961005047 generic binding surface II; other site 717961005048 generic binding surface I; other site 717961005049 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 717961005050 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 717961005051 generic binding surface II; other site 717961005052 generic binding surface I; other site 717961005053 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 717961005054 active site 717961005055 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 717961005056 active site 717961005057 catalytic site [active] 717961005058 substrate binding site [chemical binding]; other site 717961005059 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 717961005060 GcpE protein; Region: GcpE; pfam04551 717961005061 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 717961005062 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 717961005063 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 717961005064 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 717961005065 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 717961005066 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 717961005067 catalytic residue [active] 717961005068 putative FPP diphosphate binding site; other site 717961005069 putative FPP binding hydrophobic cleft; other site 717961005070 dimer interface [polypeptide binding]; other site 717961005071 putative IPP diphosphate binding site; other site 717961005072 ribosome recycling factor; Reviewed; Region: frr; PRK00083 717961005073 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 717961005074 hinge region; other site 717961005075 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 717961005076 putative nucleotide binding site [chemical binding]; other site 717961005077 uridine monophosphate binding site [chemical binding]; other site 717961005078 homohexameric interface [polypeptide binding]; other site 717961005079 homoserine dehydrogenase; Provisional; Region: PRK06349 717961005080 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 717961005081 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 717961005082 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961005083 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717961005084 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717961005085 active site 717961005086 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961005087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 717961005089 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 717961005090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961005091 active site 717961005092 phosphorylation site [posttranslational modification] 717961005093 intermolecular recognition site; other site 717961005094 dimerization interface [polypeptide binding]; other site 717961005095 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 717961005096 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717961005097 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 717961005098 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 717961005099 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 717961005100 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717961005101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717961005102 motif II; other site 717961005103 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961005104 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 717961005105 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717961005106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961005107 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 717961005108 substrate binding site [chemical binding]; other site 717961005109 active site 717961005110 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 717961005111 metal binding site [ion binding]; metal-binding site 717961005112 ligand binding site [chemical binding]; other site 717961005113 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 717961005114 active site 717961005115 catalytic residues [active] 717961005116 metal binding site [ion binding]; metal-binding site 717961005117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 717961005118 NMT1/THI5 like; Region: NMT1; pfam09084 717961005119 membrane-bound complex binding site; other site 717961005120 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717961005121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961005122 ABC-ATPase subunit interface; other site 717961005123 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717961005124 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717961005125 Walker A/P-loop; other site 717961005126 ATP binding site [chemical binding]; other site 717961005127 Q-loop/lid; other site 717961005128 ABC transporter signature motif; other site 717961005129 Walker B; other site 717961005130 D-loop; other site 717961005131 H-loop/switch region; other site 717961005132 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 717961005133 dimer interface [polypeptide binding]; other site 717961005134 substrate binding site [chemical binding]; other site 717961005135 ATP binding site [chemical binding]; other site 717961005136 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 717961005137 thiamine phosphate binding site [chemical binding]; other site 717961005138 active site 717961005139 pyrophosphate binding site [ion binding]; other site 717961005140 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 717961005141 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 717961005142 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 717961005143 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 717961005144 active site 717961005145 Predicted transcriptional regulators [Transcription]; Region: COG1695 717961005146 Transcriptional regulator PadR-like family; Region: PadR; cl17335 717961005147 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 717961005148 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 717961005149 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961005150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961005151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961005152 Walker A/P-loop; other site 717961005153 ATP binding site [chemical binding]; other site 717961005154 Q-loop/lid; other site 717961005155 ABC transporter signature motif; other site 717961005156 Walker B; other site 717961005157 D-loop; other site 717961005158 H-loop/switch region; other site 717961005159 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717961005160 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717961005161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961005162 Walker A/P-loop; other site 717961005163 ATP binding site [chemical binding]; other site 717961005164 Q-loop/lid; other site 717961005165 ABC transporter signature motif; other site 717961005166 Walker B; other site 717961005167 D-loop; other site 717961005168 H-loop/switch region; other site 717961005169 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 717961005170 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 717961005171 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 717961005172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 717961005173 active site 717961005174 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717961005175 substrate binding site [chemical binding]; other site 717961005176 catalytic residues [active] 717961005177 dimer interface [polypeptide binding]; other site 717961005178 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 717961005179 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 717961005180 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717961005181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717961005182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717961005183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961005184 active site 717961005185 phosphorylation site [posttranslational modification] 717961005186 intermolecular recognition site; other site 717961005187 dimerization interface [polypeptide binding]; other site 717961005188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717961005189 DNA binding residues [nucleotide binding] 717961005190 dimerization interface [polypeptide binding]; other site 717961005191 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 717961005192 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 717961005193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717961005194 UDP-galactopyranose mutase; Region: GLF; pfam03275 717961005195 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 717961005196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717961005197 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 717961005198 NAD(P) binding site [chemical binding]; other site 717961005199 active site 717961005200 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 717961005201 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 717961005202 NAD binding site [chemical binding]; other site 717961005203 homotetramer interface [polypeptide binding]; other site 717961005204 homodimer interface [polypeptide binding]; other site 717961005205 substrate binding site [chemical binding]; other site 717961005206 active site 717961005207 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 717961005208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 717961005209 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 717961005210 substrate binding site; other site 717961005211 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 717961005212 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 717961005213 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 717961005214 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 717961005215 substrate binding site [chemical binding]; other site 717961005216 ATP binding site [chemical binding]; other site 717961005217 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 717961005218 active site 717961005219 catalytic residues [active] 717961005220 metal binding site [ion binding]; metal-binding site 717961005221 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 717961005222 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 717961005223 Ligand binding site; other site 717961005224 oligomer interface; other site 717961005225 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 717961005226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961005227 DNA binding residues [nucleotide binding] 717961005228 sporulation sigma factor SigG; Reviewed; Region: PRK08215 717961005229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005230 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 717961005231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961005232 DNA binding residues [nucleotide binding] 717961005233 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 717961005234 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005235 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005236 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005237 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 717961005238 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717961005239 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 717961005240 NAD synthetase; Reviewed; Region: nadE; PRK02628 717961005241 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 717961005242 multimer interface [polypeptide binding]; other site 717961005243 active site 717961005244 catalytic triad [active] 717961005245 protein interface 1 [polypeptide binding]; other site 717961005246 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 717961005247 homodimer interface [polypeptide binding]; other site 717961005248 NAD binding pocket [chemical binding]; other site 717961005249 ATP binding pocket [chemical binding]; other site 717961005250 Mg binding site [ion binding]; other site 717961005251 active-site loop [active] 717961005252 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 717961005253 FtsX-like permease family; Region: FtsX; pfam02687 717961005254 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961005255 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961005256 Walker A/P-loop; other site 717961005257 ATP binding site [chemical binding]; other site 717961005258 Q-loop/lid; other site 717961005259 ABC transporter signature motif; other site 717961005260 Walker B; other site 717961005261 D-loop; other site 717961005262 H-loop/switch region; other site 717961005263 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961005264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961005266 DNA binding residues [nucleotide binding] 717961005267 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 717961005268 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717961005269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717961005270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717961005271 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717961005272 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717961005273 FtsX-like permease family; Region: FtsX; pfam02687 717961005274 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 717961005275 HlyD family secretion protein; Region: HlyD_3; pfam13437 717961005276 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961005277 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961005278 Walker A/P-loop; other site 717961005279 ATP binding site [chemical binding]; other site 717961005280 Q-loop/lid; other site 717961005281 ABC transporter signature motif; other site 717961005282 Walker B; other site 717961005283 D-loop; other site 717961005284 H-loop/switch region; other site 717961005285 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961005286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961005288 DNA binding residues [nucleotide binding] 717961005289 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717961005290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961005291 Walker A/P-loop; other site 717961005292 ATP binding site [chemical binding]; other site 717961005293 Q-loop/lid; other site 717961005294 ABC transporter signature motif; other site 717961005295 Walker B; other site 717961005296 D-loop; other site 717961005297 H-loop/switch region; other site 717961005298 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 717961005299 metal binding site [ion binding]; metal-binding site 717961005300 Paraflagellar rod protein; Region: Flagellar_rod; pfam05149 717961005301 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 717961005302 active site 717961005303 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 717961005304 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 717961005305 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 717961005306 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 717961005307 Peptidase family M50; Region: Peptidase_M50; pfam02163 717961005308 active site 717961005309 putative substrate binding region [chemical binding]; other site 717961005310 ScpA/B protein; Region: ScpA_ScpB; cl00598 717961005311 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 717961005312 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 717961005313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961005314 RNA binding surface [nucleotide binding]; other site 717961005315 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 717961005316 active site 717961005317 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 717961005318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717961005319 substrate binding site [chemical binding]; other site 717961005320 oxyanion hole (OAH) forming residues; other site 717961005321 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 717961005322 carboxyltransferase (CT) interaction site; other site 717961005323 biotinylation site [posttranslational modification]; other site 717961005324 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 717961005325 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717961005326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717961005327 Walker A/P-loop; other site 717961005328 ATP binding site [chemical binding]; other site 717961005329 Q-loop/lid; other site 717961005330 ABC transporter signature motif; other site 717961005331 Walker B; other site 717961005332 D-loop; other site 717961005333 H-loop/switch region; other site 717961005334 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 717961005335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 717961005336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 717961005337 TPR motif; other site 717961005338 binding surface 717961005339 TPR repeat; Region: TPR_11; pfam13414 717961005340 Tetratricopeptide repeat; Region: TPR_1; pfam00515 717961005341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717961005342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717961005343 DNA binding residues [nucleotide binding] 717961005344 dimerization interface [polypeptide binding]; other site 717961005345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717961005346 DNA-binding site [nucleotide binding]; DNA binding site 717961005347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 717961005348 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 717961005349 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 717961005350 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 717961005351 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 717961005352 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 717961005353 Walker A/P-loop; other site 717961005354 ATP binding site [chemical binding]; other site 717961005355 Q-loop/lid; other site 717961005356 ABC transporter signature motif; other site 717961005357 Walker B; other site 717961005358 D-loop; other site 717961005359 H-loop/switch region; other site 717961005360 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 717961005361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717961005362 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 717961005363 TM-ABC transporter signature motif; other site 717961005364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717961005365 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 717961005366 TM-ABC transporter signature motif; other site 717961005367 L-arabinose isomerase; Provisional; Region: PRK02929 717961005368 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 717961005369 hexamer (dimer of trimers) interface [polypeptide binding]; other site 717961005370 trimer interface [polypeptide binding]; other site 717961005371 substrate binding site [chemical binding]; other site 717961005372 Mn binding site [ion binding]; other site 717961005373 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 717961005374 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 717961005375 putative N- and C-terminal domain interface [polypeptide binding]; other site 717961005376 putative active site [active] 717961005377 MgATP binding site [chemical binding]; other site 717961005378 catalytic site [active] 717961005379 metal binding site [ion binding]; metal-binding site 717961005380 putative carbohydrate binding site [chemical binding]; other site 717961005381 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 717961005382 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 717961005383 intersubunit interface [polypeptide binding]; other site 717961005384 active site 717961005385 Zn2+ binding site [ion binding]; other site 717961005386 FtsX-like permease family; Region: FtsX; pfam02687 717961005387 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717961005388 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717961005389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717961005390 Walker A/P-loop; other site 717961005391 ATP binding site [chemical binding]; other site 717961005392 Q-loop/lid; other site 717961005393 ABC transporter signature motif; other site 717961005394 Walker B; other site 717961005395 D-loop; other site 717961005396 H-loop/switch region; other site 717961005397 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 717961005398 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 717961005399 ligand binding site [chemical binding]; other site 717961005400 dimerization interface [polypeptide binding]; other site 717961005401 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 717961005402 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 717961005403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717961005404 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 717961005405 substrate binding site [chemical binding]; other site 717961005406 active site 717961005407 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 717961005408 metal binding site [ion binding]; metal-binding site 717961005409 ligand binding site [chemical binding]; other site 717961005410 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 717961005411 substrate binding site [chemical binding]; other site 717961005412 active site 717961005413 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 717961005414 metal binding site [ion binding]; metal-binding site 717961005415 ligand binding site [chemical binding]; other site 717961005416 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 717961005417 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 717961005418 active site 717961005419 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 717961005420 Protein of unknown function DUF262; Region: DUF262; pfam03235 717961005421 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 717961005422 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717961005423 active site 717961005424 ATP binding site [chemical binding]; other site 717961005425 substrate binding site [chemical binding]; other site 717961005426 activation loop (A-loop); other site 717961005427 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 717961005428 AAA domain; Region: AAA_14; pfam13173 717961005429 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 717961005430 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 717961005431 Active Sites [active] 717961005432 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 717961005433 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717961005434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717961005435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717961005436 catalytic residue [active] 717961005437 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 717961005438 PLD-like domain; Region: PLDc_2; pfam13091 717961005439 putative active site [active] 717961005440 catalytic site [active] 717961005441 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 717961005442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717961005443 ATP binding site [chemical binding]; other site 717961005444 putative Mg++ binding site [ion binding]; other site 717961005445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717961005446 nucleotide binding region [chemical binding]; other site 717961005447 ATP-binding site [chemical binding]; other site 717961005448 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 717961005449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961005450 Walker A/P-loop; other site 717961005451 ATP binding site [chemical binding]; other site 717961005452 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 717961005453 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 717961005454 Helix-turn-helix domain; Region: HTH_17; cl17695 717961005455 Helix-turn-helix domain; Region: HTH_36; pfam13730 717961005456 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717961005457 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 717961005458 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 717961005459 Int/Topo IB signature motif; other site 717961005460 Cellulose binding domain; Region: CBM_2; pfam00553 717961005461 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 717961005462 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961005463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 717961005464 YbbR-like protein; Region: YbbR; pfam07949 717961005465 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 717961005466 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 717961005467 dimer interface [polypeptide binding]; other site 717961005468 PYR/PP interface [polypeptide binding]; other site 717961005469 TPP binding site [chemical binding]; other site 717961005470 substrate binding site [chemical binding]; other site 717961005471 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 717961005472 Domain of unknown function; Region: EKR; smart00890 717961005473 4Fe-4S binding domain; Region: Fer4_6; pfam12837 717961005474 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 717961005475 TPP-binding site [chemical binding]; other site 717961005476 dimer interface [polypeptide binding]; other site 717961005477 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 717961005478 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 717961005479 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 717961005480 active site 717961005481 substrate-binding site [chemical binding]; other site 717961005482 metal-binding site [ion binding] 717961005483 GTP binding site [chemical binding]; other site 717961005484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717961005485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961005486 dimer interface [polypeptide binding]; other site 717961005487 conserved gate region; other site 717961005488 putative PBP binding loops; other site 717961005489 ABC-ATPase subunit interface; other site 717961005490 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 717961005491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961005492 dimer interface [polypeptide binding]; other site 717961005493 conserved gate region; other site 717961005494 putative PBP binding loops; other site 717961005495 ABC-ATPase subunit interface; other site 717961005496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 717961005497 AIR carboxylase; Region: AIRC; pfam00731 717961005498 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 717961005499 active site 717961005500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717961005501 active site 717961005502 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 717961005503 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 717961005504 dimerization interface [polypeptide binding]; other site 717961005505 putative ATP binding site [chemical binding]; other site 717961005506 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 717961005507 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 717961005508 active site 717961005509 substrate binding site [chemical binding]; other site 717961005510 cosubstrate binding site; other site 717961005511 catalytic site [active] 717961005512 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 717961005513 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 717961005514 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 717961005515 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717961005516 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717961005517 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717961005518 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717961005519 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 717961005520 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 717961005521 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 717961005522 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 717961005523 Preprotein translocase SecG subunit; Region: SecG; pfam03840 717961005524 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717961005525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717961005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961005527 active site 717961005528 phosphorylation site [posttranslational modification] 717961005529 intermolecular recognition site; other site 717961005530 dimerization interface [polypeptide binding]; other site 717961005531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717961005532 DNA binding site [nucleotide binding] 717961005533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717961005534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717961005535 dimer interface [polypeptide binding]; other site 717961005536 phosphorylation site [posttranslational modification] 717961005537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961005538 ATP binding site [chemical binding]; other site 717961005539 Mg2+ binding site [ion binding]; other site 717961005540 G-X-G motif; other site 717961005541 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 717961005542 Transposase; Region: DDE_Tnp_ISL3; pfam01610 717961005543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 717961005544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961005545 Coenzyme A binding pocket [chemical binding]; other site 717961005546 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 717961005547 Nitroreductase family; Region: Nitroreductase; pfam00881 717961005548 FMN binding site [chemical binding]; other site 717961005549 dimer interface [polypeptide binding]; other site 717961005550 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 717961005551 nudix motif; other site 717961005552 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961005553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961005554 non-specific DNA binding site [nucleotide binding]; other site 717961005555 salt bridge; other site 717961005556 sequence-specific DNA binding site [nucleotide binding]; other site 717961005557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717961005558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717961005559 S-adenosylmethionine binding site [chemical binding]; other site 717961005560 Helix-turn-helix domain; Region: HTH_28; pfam13518 717961005561 HTH-like domain; Region: HTH_21; pfam13276 717961005562 Integrase core domain; Region: rve; pfam00665 717961005563 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 717961005564 ATP cone domain; Region: ATP-cone; pfam03477 717961005565 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 717961005566 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 717961005567 Protein export membrane protein; Region: SecD_SecF; cl14618 717961005568 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 717961005569 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 717961005570 tetramer interface [polypeptide binding]; other site 717961005571 active site 717961005572 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 717961005573 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 717961005574 phosphodiesterase; Provisional; Region: PRK12704 717961005575 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 717961005576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717961005577 Zn2+ binding site [ion binding]; other site 717961005578 Mg2+ binding site [ion binding]; other site 717961005579 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961005580 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 717961005581 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 717961005582 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961005583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005584 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 717961005585 DNA binding residues [nucleotide binding] 717961005586 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 717961005587 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 717961005588 putative ATP binding site [chemical binding]; other site 717961005589 putative substrate interface [chemical binding]; other site 717961005590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961005591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961005592 non-specific DNA binding site [nucleotide binding]; other site 717961005593 salt bridge; other site 717961005594 sequence-specific DNA binding site [nucleotide binding]; other site 717961005595 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717961005596 UGMP family protein; Validated; Region: PRK09604 717961005597 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 717961005598 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 717961005599 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717961005600 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 717961005601 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 717961005602 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 717961005603 alphaNTD - beta interaction site [polypeptide binding]; other site 717961005604 alphaNTD homodimer interface [polypeptide binding]; other site 717961005605 alphaNTD - beta' interaction site [polypeptide binding]; other site 717961005606 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 717961005607 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 717961005608 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 717961005609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961005610 RNA binding surface [nucleotide binding]; other site 717961005611 30S ribosomal protein S11; Validated; Region: PRK05309 717961005612 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 717961005613 30S ribosomal protein S13; Region: bact_S13; TIGR03631 717961005614 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 717961005615 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 717961005616 RNA binding site [nucleotide binding]; other site 717961005617 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 717961005618 active site 717961005619 adenylate kinase; Reviewed; Region: adk; PRK00279 717961005620 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 717961005621 AMP-binding site [chemical binding]; other site 717961005622 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 717961005623 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 717961005624 23S rRNA binding site [nucleotide binding]; other site 717961005625 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 717961005626 5S rRNA interface [nucleotide binding]; other site 717961005627 23S rRNA interface [nucleotide binding]; other site 717961005628 L5 interface [polypeptide binding]; other site 717961005629 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 717961005630 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 717961005631 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 717961005632 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 717961005633 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 717961005634 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 717961005635 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 717961005636 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 717961005637 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 717961005638 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 717961005639 RNA binding site [nucleotide binding]; other site 717961005640 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 717961005641 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 717961005642 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 717961005643 23S rRNA interface [nucleotide binding]; other site 717961005644 putative translocon interaction site; other site 717961005645 signal recognition particle (SRP54) interaction site; other site 717961005646 L23 interface [polypeptide binding]; other site 717961005647 trigger factor interaction site; other site 717961005648 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 717961005649 23S rRNA interface [nucleotide binding]; other site 717961005650 5S rRNA interface [nucleotide binding]; other site 717961005651 putative antibiotic binding site [chemical binding]; other site 717961005652 L25 interface [polypeptide binding]; other site 717961005653 L27 interface [polypeptide binding]; other site 717961005654 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 717961005655 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 717961005656 G-X-X-G motif; other site 717961005657 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 717961005658 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 717961005659 putative translocon binding site; other site 717961005660 protein-rRNA interface [nucleotide binding]; other site 717961005661 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 717961005662 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 717961005663 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 717961005664 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 717961005665 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 717961005666 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 717961005667 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 717961005668 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 717961005669 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005670 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005671 Interdomain contacts; other site 717961005672 Cytokine receptor motif; other site 717961005673 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005674 Interdomain contacts; other site 717961005675 Bacterial Ig-like domain 2; Region: BID_2; smart00635 717961005676 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005677 Interdomain contacts; other site 717961005678 Cytokine receptor motif; other site 717961005679 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005680 Interdomain contacts; other site 717961005681 Cytokine receptor motif; other site 717961005682 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005683 Interdomain contacts; other site 717961005684 Cytokine receptor motif; other site 717961005685 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005686 Interdomain contacts; other site 717961005687 Cytokine receptor motif; other site 717961005688 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005689 Interdomain contacts; other site 717961005690 Cytokine receptor motif; other site 717961005691 Domain of unknown function (DUF348); Region: DUF348; pfam03990 717961005692 Domain of unknown function (DUF348); Region: DUF348; pfam03990 717961005693 G5 domain; Region: G5; pfam07501 717961005694 3D domain; Region: 3D; cl01439 717961005695 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 717961005696 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005697 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005698 Leucine rich repeat; Region: LRR_8; pfam13855 717961005699 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005700 Interdomain contacts; other site 717961005701 Cytokine receptor motif; other site 717961005702 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005703 Interdomain contacts; other site 717961005704 Cytokine receptor motif; other site 717961005705 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005706 Interdomain contacts; other site 717961005707 Cytokine receptor motif; other site 717961005708 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005709 Interdomain contacts; other site 717961005710 Cytokine receptor motif; other site 717961005711 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005712 Interdomain contacts; other site 717961005713 Cytokine receptor motif; other site 717961005714 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005715 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005716 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 717961005717 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005718 Interdomain contacts; other site 717961005719 Cytokine receptor motif; other site 717961005720 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005721 Interdomain contacts; other site 717961005722 Cytokine receptor motif; other site 717961005723 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005724 Interdomain contacts; other site 717961005725 Cytokine receptor motif; other site 717961005726 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005727 Interdomain contacts; other site 717961005728 Cytokine receptor motif; other site 717961005729 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 717961005730 Interdomain contacts; other site 717961005731 Cytokine receptor motif; other site 717961005732 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 717961005733 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 717961005734 Acid Phosphatase; Region: Acid_PPase; cl17256 717961005735 DHHW protein; Region: DHHW; pfam14286 717961005736 DHHW protein; Region: DHHW; pfam14286 717961005737 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 717961005738 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 717961005739 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717961005740 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 717961005741 nudix motif; other site 717961005742 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 717961005743 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 717961005744 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 717961005745 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 717961005746 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 717961005747 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 717961005748 metal binding site [ion binding]; metal-binding site 717961005749 ligand binding site [chemical binding]; other site 717961005750 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 717961005751 NlpC/P60 family; Region: NLPC_P60; pfam00877 717961005752 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 717961005753 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717961005754 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717961005755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005756 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 717961005757 DNA binding residues [nucleotide binding] 717961005758 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717961005759 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717961005760 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717961005761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717961005762 dimerization interface [polypeptide binding]; other site 717961005763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717961005764 PAS fold; Region: PAS_3; pfam08447 717961005765 putative active site [active] 717961005766 heme pocket [chemical binding]; other site 717961005767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717961005768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717961005769 metal binding site [ion binding]; metal-binding site 717961005770 active site 717961005771 I-site; other site 717961005772 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 717961005773 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 717961005774 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 717961005775 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717961005776 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 717961005777 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 717961005778 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 717961005779 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 717961005780 FliG C-terminal domain; Region: FliG_C; pfam01706 717961005781 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 717961005782 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717961005783 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 717961005784 Walker A motif/ATP binding site; other site 717961005785 Walker B motif; other site 717961005786 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 717961005787 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 717961005788 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 717961005789 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 717961005790 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717961005791 Flagellar protein (FlbD); Region: FlbD; pfam06289 717961005792 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 717961005793 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 717961005794 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717961005795 ligand binding site [chemical binding]; other site 717961005796 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 717961005797 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 717961005798 flagellar motor switch protein; Validated; Region: PRK08119 717961005799 CheC-like family; Region: CheC; pfam04509 717961005800 CheC-like family; Region: CheC; pfam04509 717961005801 flagellar motor switch protein FliN; Region: fliN; TIGR02480 717961005802 Response regulator receiver domain; Region: Response_reg; pfam00072 717961005803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717961005804 active site 717961005805 phosphorylation site [posttranslational modification] 717961005806 intermolecular recognition site; other site 717961005807 dimerization interface [polypeptide binding]; other site 717961005808 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 717961005809 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 717961005810 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 717961005811 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 717961005812 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 717961005813 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 717961005814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005815 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 717961005816 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961005817 DNA binding residues [nucleotide binding] 717961005818 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 717961005819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 717961005820 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 717961005821 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 717961005822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717961005823 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 717961005824 CheC-like family; Region: CheC; pfam04509 717961005825 CheC-like family; Region: CheC; pfam04509 717961005826 Protein of unknown function (DUF342); Region: DUF342; pfam03961 717961005827 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 717961005828 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717961005829 active site 717961005830 HIGH motif; other site 717961005831 nucleotide binding site [chemical binding]; other site 717961005832 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717961005833 active site 717961005834 KMSKS motif; other site 717961005835 PUA domain; Region: PUA; cl00607 717961005836 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 717961005837 Type III pantothenate kinase; Region: Pan_kinase; cl17198 717961005838 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 717961005839 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 717961005840 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 717961005841 Ligand binding site; other site 717961005842 Putative Catalytic site; other site 717961005843 DXD motif; other site 717961005844 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 717961005845 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 717961005846 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 717961005847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961005848 ATP binding site [chemical binding]; other site 717961005849 Mg2+ binding site [ion binding]; other site 717961005850 G-X-G motif; other site 717961005851 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 717961005852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717961005853 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 717961005854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717961005855 DNA binding residues [nucleotide binding] 717961005856 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 717961005857 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 717961005858 active site 717961005859 multimer interface [polypeptide binding]; other site 717961005860 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 717961005861 predicted active site [active] 717961005862 catalytic triad [active] 717961005863 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 717961005864 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 717961005865 dimer interface [polypeptide binding]; other site 717961005866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961005867 catalytic residue [active] 717961005868 allantoate amidohydrolase; Reviewed; Region: PRK09290 717961005869 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 717961005870 active site 717961005871 metal binding site [ion binding]; metal-binding site 717961005872 dimer interface [polypeptide binding]; other site 717961005873 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 717961005874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961005875 Walker A motif; other site 717961005876 ATP binding site [chemical binding]; other site 717961005877 Walker B motif; other site 717961005878 arginine finger; other site 717961005879 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 717961005880 hypothetical protein; Validated; Region: PRK00153 717961005881 recombination protein RecR; Reviewed; Region: recR; PRK00076 717961005882 RecR protein; Region: RecR; pfam02132 717961005883 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 717961005884 putative active site [active] 717961005885 putative metal-binding site [ion binding]; other site 717961005886 tetramer interface [polypeptide binding]; other site 717961005887 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 717961005888 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 717961005889 substrate binding site [chemical binding]; other site 717961005890 hexamer interface [polypeptide binding]; other site 717961005891 metal binding site [ion binding]; metal-binding site 717961005892 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 717961005893 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 717961005894 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 717961005895 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 717961005896 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 717961005897 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 717961005898 acyl carrier protein; Provisional; Region: acpP; PRK00982 717961005899 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 717961005900 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 717961005901 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 717961005902 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 717961005903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717961005904 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 717961005905 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 717961005906 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 717961005907 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 717961005908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 717961005909 carboxyltransferase (CT) interaction site; other site 717961005910 biotinylation site [posttranslational modification]; other site 717961005911 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717961005912 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 717961005913 dimer interface [polypeptide binding]; other site 717961005914 active site 717961005915 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 717961005916 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 717961005917 NAD(P) binding site [chemical binding]; other site 717961005918 homotetramer interface [polypeptide binding]; other site 717961005919 homodimer interface [polypeptide binding]; other site 717961005920 active site 717961005921 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 717961005922 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 717961005923 FMN binding site [chemical binding]; other site 717961005924 substrate binding site [chemical binding]; other site 717961005925 putative catalytic residue [active] 717961005926 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 717961005927 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717961005928 dimer interface [polypeptide binding]; other site 717961005929 active site 717961005930 CoA binding pocket [chemical binding]; other site 717961005931 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 717961005932 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 717961005933 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 717961005934 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 717961005935 active site 717961005936 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 717961005937 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 717961005938 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 717961005939 shikimate binding site; other site 717961005940 NAD(P) binding site [chemical binding]; other site 717961005941 shikimate kinase; Reviewed; Region: aroK; PRK00131 717961005942 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 717961005943 ADP binding site [chemical binding]; other site 717961005944 magnesium binding site [ion binding]; other site 717961005945 putative shikimate binding site; other site 717961005946 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 717961005947 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 717961005948 active site 717961005949 fumarate hydratase; Provisional; Region: PRK06246 717961005950 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717961005951 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 717961005952 EDD domain protein, DegV family; Region: DegV; TIGR00762 717961005953 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 717961005954 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 717961005955 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 717961005956 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 717961005957 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 717961005958 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717961005959 catalytic residue [active] 717961005960 AAA domain; Region: AAA_14; pfam13173 717961005961 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 717961005962 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717961005963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717961005964 non-specific DNA binding site [nucleotide binding]; other site 717961005965 salt bridge; other site 717961005966 sequence-specific DNA binding site [nucleotide binding]; other site 717961005967 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 717961005968 AAA domain; Region: AAA_14; pfam13173 717961005969 RmuC family; Region: RmuC; pfam02646 717961005970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 717961005971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717961005972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717961005973 dimer interface [polypeptide binding]; other site 717961005974 putative CheW interface [polypeptide binding]; other site 717961005975 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 717961005976 active site 717961005977 catalytic triad [active] 717961005978 oxyanion hole [active] 717961005979 PemK-like protein; Region: PemK; pfam02452 717961005980 6-phosphofructokinase; Provisional; Region: PRK14072 717961005981 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 717961005982 active site 717961005983 ADP/pyrophosphate binding site [chemical binding]; other site 717961005984 dimerization interface [polypeptide binding]; other site 717961005985 allosteric effector site; other site 717961005986 fructose-1,6-bisphosphate binding site; other site 717961005987 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 717961005988 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 717961005989 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 717961005990 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717961005991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717961005992 dimer interface [polypeptide binding]; other site 717961005993 conserved gate region; other site 717961005994 putative PBP binding loops; other site 717961005995 ABC-ATPase subunit interface; other site 717961005996 NMT1/THI5 like; Region: NMT1; pfam09084 717961005997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 717961005998 Uncharacterized conserved protein [Function unknown]; Region: COG1683 717961005999 hypothetical protein; Provisional; Region: PRK06062 717961006000 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717961006001 inhibitor-cofactor binding pocket; inhibition site 717961006002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961006003 catalytic residue [active] 717961006004 phenylhydantoinase; Validated; Region: PRK08323 717961006005 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 717961006006 tetramer interface [polypeptide binding]; other site 717961006007 active site 717961006008 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 717961006009 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 717961006010 homodimer interface [polypeptide binding]; other site 717961006011 active site 717961006012 FMN binding site [chemical binding]; other site 717961006013 substrate binding site [chemical binding]; other site 717961006014 4Fe-4S binding domain; Region: Fer4; pfam00037 717961006015 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 717961006016 FlgN protein; Region: FlgN; pfam05130 717961006017 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 717961006018 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 717961006019 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 717961006020 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 717961006021 FliW protein; Region: FliW; cl00740 717961006022 Global regulator protein family; Region: CsrA; pfam02599 717961006023 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 717961006024 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 717961006025 Flagellar protein FliS; Region: FliS; cl00654 717961006026 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 717961006027 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717961006028 homodimer interface [polypeptide binding]; other site 717961006029 substrate-cofactor binding pocket; other site 717961006030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717961006031 catalytic residue [active] 717961006032 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 717961006033 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 717961006034 Ligand Binding Site [chemical binding]; other site 717961006035 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 717961006036 toxin interface [polypeptide binding]; other site 717961006037 Zn binding site [ion binding]; other site 717961006038 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 717961006039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717961006040 Coenzyme A binding pocket [chemical binding]; other site 717961006041 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 717961006042 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 717961006043 active site 717961006044 HIGH motif; other site 717961006045 dimer interface [polypeptide binding]; other site 717961006046 KMSKS motif; other site 717961006047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961006048 RNA binding surface [nucleotide binding]; other site 717961006049 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 717961006050 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 717961006051 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 717961006052 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 717961006053 putative metal binding residues [ion binding]; other site 717961006054 signature motif; other site 717961006055 dimer interface [polypeptide binding]; other site 717961006056 active site 717961006057 polyP binding site; other site 717961006058 substrate binding site [chemical binding]; other site 717961006059 acceptor-phosphate pocket; other site 717961006060 pyruvate kinase; Provisional; Region: PRK06354 717961006061 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 717961006062 domain interfaces; other site 717961006063 active site 717961006064 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 717961006065 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 717961006066 DnaA N-terminal domain; Region: DnaA_N; pfam11638 717961006067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717961006068 Walker A motif; other site 717961006069 ATP binding site [chemical binding]; other site 717961006070 Walker B motif; other site 717961006071 arginine finger; other site 717961006072 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 717961006073 DnaA box-binding interface [nucleotide binding]; other site 717961006074 DNA polymerase III subunit beta; Validated; Region: PRK05643 717961006075 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 717961006076 putative DNA binding surface [nucleotide binding]; other site 717961006077 dimer interface [polypeptide binding]; other site 717961006078 beta-clamp/clamp loader binding surface; other site 717961006079 beta-clamp/translesion DNA polymerase binding surface; other site 717961006080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717961006081 RNA binding surface [nucleotide binding]; other site 717961006082 recombination protein F; Reviewed; Region: recF; PRK00064 717961006083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961006084 Walker A/P-loop; other site 717961006085 ATP binding site [chemical binding]; other site 717961006086 Q-loop/lid; other site 717961006087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961006088 ABC transporter signature motif; other site 717961006089 Walker B; other site 717961006090 D-loop; other site 717961006091 H-loop/switch region; other site 717961006092 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 717961006093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717961006094 Mg2+ binding site [ion binding]; other site 717961006095 G-X-G motif; other site 717961006096 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 717961006097 anchoring element; other site 717961006098 dimer interface [polypeptide binding]; other site 717961006099 ATP binding site [chemical binding]; other site 717961006100 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 717961006101 active site 717961006102 putative metal-binding site [ion binding]; other site 717961006103 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 717961006104 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 717961006105 YcxB-like protein; Region: YcxB; pfam14317 717961006106 DNA gyrase subunit A; Validated; Region: PRK05560 717961006107 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 717961006108 CAP-like domain; other site 717961006109 active site 717961006110 primary dimer interface [polypeptide binding]; other site 717961006111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717961006112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717961006113 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717961006114 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717961006115 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717961006116 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717961006117 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 717961006118 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 717961006119 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 717961006120 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 717961006121 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 717961006122 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 717961006123 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 717961006124 ParB-like nuclease domain; Region: ParBc; pfam02195 717961006125 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717961006126 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717961006127 P-loop; other site 717961006128 Magnesium ion binding site [ion binding]; other site 717961006129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717961006130 Magnesium ion binding site [ion binding]; other site 717961006131 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 717961006132 ParB-like nuclease domain; Region: ParBc; pfam02195 717961006133 KorB domain; Region: KorB; pfam08535 717961006134 seryl-tRNA synthetase; Provisional; Region: PRK05431 717961006135 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 717961006136 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717961006137 motif 1; other site 717961006138 dimer interface [polypeptide binding]; other site 717961006139 active site 717961006140 motif 2; other site 717961006141 motif 3; other site 717961006142 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 717961006143 active site 1 [active] 717961006144 active site 2 [active] 717961006145 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 717961006146 active site 2 [active] 717961006147 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717961006148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717961006149 Walker A/P-loop; other site 717961006150 ATP binding site [chemical binding]; other site 717961006151 Q-loop/lid; other site 717961006152 ABC transporter signature motif; other site 717961006153 Walker B; other site 717961006154 D-loop; other site 717961006155 H-loop/switch region; other site 717961006156 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 717961006157 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717961006158 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486