-- dump date 20140619_092235 -- class Genbank::misc_feature -- table misc_feature_note -- id note 360911000001 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 360911000002 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 360911000003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911000004 ATP binding site [chemical binding]; other site 360911000005 putative Mg++ binding site [ion binding]; other site 360911000006 helicase superfamily c-terminal domain; Region: HELICc; smart00490 360911000007 ATP-binding site [chemical binding]; other site 360911000008 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 360911000009 nucleotide binding site [chemical binding]; other site 360911000010 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 360911000011 HNH endonuclease; Region: HNH_3; pfam13392 360911000012 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 360911000013 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 360911000014 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 360911000015 active site 360911000016 catalytic site [active] 360911000017 substrate binding site [chemical binding]; other site 360911000018 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 360911000019 active site 360911000020 DNA binding site [nucleotide binding] 360911000021 catalytic site [active] 360911000022 3D domain; Region: 3D; cl01439 360911000023 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 360911000024 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 360911000025 Terminase-like family; Region: Terminase_6; pfam03237 360911000026 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 360911000027 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 360911000028 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 360911000029 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 360911000030 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 360911000031 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 360911000032 Phage XkdN-like protein; Region: XkdN; pfam08890 360911000033 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 360911000034 Phage-related protein [Function unknown]; Region: COG5412 360911000035 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911000036 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 360911000037 3D domain; Region: 3D; cl01439 360911000038 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360911000039 NlpC/P60 family; Region: NLPC_P60; pfam00877 360911000040 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 360911000041 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 360911000042 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 360911000043 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 360911000044 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 360911000045 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911000046 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 360911000047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911000048 RNase_H superfamily; Region: RNase_H_2; pfam13482 360911000049 active site 360911000050 substrate binding site [chemical binding]; other site 360911000051 hypothetical protein; Provisional; Region: PRK13660 360911000052 cell division protein GpsB; Provisional; Region: PRK14127 360911000053 DivIVA domain; Region: DivI1A_domain; TIGR03544 360911000054 Nuclease-related domain; Region: NERD; pfam08378 360911000055 FAD binding domain; Region: FAD_binding_3; pfam01494 360911000056 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 360911000057 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 360911000058 putative active site [active] 360911000059 putative CoA binding site [chemical binding]; other site 360911000060 nudix motif; other site 360911000061 metal binding site [ion binding]; metal-binding site 360911000062 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 360911000063 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 360911000064 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 360911000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 360911000066 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 360911000067 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 360911000068 Walker A/P-loop; other site 360911000069 ATP binding site [chemical binding]; other site 360911000070 Q-loop/lid; other site 360911000071 ABC transporter signature motif; other site 360911000072 Walker B; other site 360911000073 D-loop; other site 360911000074 H-loop/switch region; other site 360911000075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000076 dimer interface [polypeptide binding]; other site 360911000077 conserved gate region; other site 360911000078 ABC-ATPase subunit interface; other site 360911000079 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 360911000080 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 360911000081 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 360911000082 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 360911000083 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 360911000084 Na2 binding site [ion binding]; other site 360911000085 putative substrate binding site 1 [chemical binding]; other site 360911000086 Na binding site 1 [ion binding]; other site 360911000087 putative substrate binding site 2 [chemical binding]; other site 360911000088 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 360911000089 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 360911000090 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 360911000091 active site 360911000092 Zn binding site [ion binding]; other site 360911000093 histidinol-phosphatase; Reviewed; Region: PRK08123 360911000094 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 360911000095 active site 360911000096 dimer interface [polypeptide binding]; other site 360911000097 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 360911000098 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 360911000099 motif 1; other site 360911000100 dimer interface [polypeptide binding]; other site 360911000101 active site 360911000102 motif 2; other site 360911000103 motif 3; other site 360911000104 ATP phosphoribosyltransferase; Region: HisG; cl15266 360911000105 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 360911000106 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 360911000107 histidinol dehydrogenase; Region: hisD; TIGR00069 360911000108 NAD binding site [chemical binding]; other site 360911000109 dimerization interface [polypeptide binding]; other site 360911000110 product binding site; other site 360911000111 substrate binding site [chemical binding]; other site 360911000112 zinc binding site [ion binding]; other site 360911000113 catalytic residues [active] 360911000114 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 360911000115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000117 homodimer interface [polypeptide binding]; other site 360911000118 catalytic residue [active] 360911000119 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 360911000120 putative active site pocket [active] 360911000121 4-fold oligomerization interface [polypeptide binding]; other site 360911000122 metal binding residues [ion binding]; metal-binding site 360911000123 3-fold/trimer interface [polypeptide binding]; other site 360911000124 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 360911000125 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 360911000126 putative active site [active] 360911000127 oxyanion strand; other site 360911000128 catalytic triad [active] 360911000129 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 360911000130 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 360911000131 catalytic residues [active] 360911000132 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 360911000133 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 360911000134 substrate binding site [chemical binding]; other site 360911000135 glutamase interaction surface [polypeptide binding]; other site 360911000136 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 360911000137 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 360911000138 metal binding site [ion binding]; metal-binding site 360911000139 maltose O-acetyltransferase; Provisional; Region: PRK10092 360911000140 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 360911000141 active site 360911000142 substrate binding site [chemical binding]; other site 360911000143 trimer interface [polypeptide binding]; other site 360911000144 CoA binding site [chemical binding]; other site 360911000145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000146 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 360911000147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000148 homodimer interface [polypeptide binding]; other site 360911000149 catalytic residue [active] 360911000150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911000151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911000152 substrate binding pocket [chemical binding]; other site 360911000153 membrane-bound complex binding site; other site 360911000154 hinge residues; other site 360911000155 AAA domain; Region: AAA_33; pfam13671 360911000156 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 360911000157 active site 360911000158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000159 Coenzyme A binding pocket [chemical binding]; other site 360911000160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911000161 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911000162 active site 360911000163 topology modulation protein; Reviewed; Region: PRK08118 360911000164 AAA domain; Region: AAA_17; pfam13207 360911000165 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 360911000166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000167 Coenzyme A binding pocket [chemical binding]; other site 360911000168 Predicted membrane protein [Function unknown]; Region: COG4550 360911000169 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 360911000170 MutS domain I; Region: MutS_I; pfam01624 360911000171 MutS domain II; Region: MutS_II; pfam05188 360911000172 MutS domain III; Region: MutS_III; pfam05192 360911000173 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 360911000174 Walker A/P-loop; other site 360911000175 ATP binding site [chemical binding]; other site 360911000176 Q-loop/lid; other site 360911000177 ABC transporter signature motif; other site 360911000178 Walker B; other site 360911000179 D-loop; other site 360911000180 H-loop/switch region; other site 360911000181 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 360911000182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911000183 ATP binding site [chemical binding]; other site 360911000184 Mg2+ binding site [ion binding]; other site 360911000185 G-X-G motif; other site 360911000186 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 360911000187 ATP binding site [chemical binding]; other site 360911000188 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 360911000189 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 360911000190 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 360911000191 5S rRNA interface [nucleotide binding]; other site 360911000192 CTC domain interface [polypeptide binding]; other site 360911000193 L16 interface [polypeptide binding]; other site 360911000194 Cupin domain; Region: Cupin_2; cl17218 360911000195 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 360911000196 RNAase interaction site [polypeptide binding]; other site 360911000197 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 360911000198 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 360911000199 Class III ribonucleotide reductase; Region: RNR_III; cd01675 360911000200 effector binding site; other site 360911000201 active site 360911000202 Zn binding site [ion binding]; other site 360911000203 glycine loop; other site 360911000204 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 360911000205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911000206 FeS/SAM binding site; other site 360911000207 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 360911000208 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 360911000209 serine endoprotease; Provisional; Region: PRK10898 360911000210 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 360911000211 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911000212 protein binding site [polypeptide binding]; other site 360911000213 Predicted membrane protein [Function unknown]; Region: COG4270 360911000214 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 360911000215 amidohydrolase; Region: amidohydrolases; TIGR01891 360911000216 metal binding site [ion binding]; metal-binding site 360911000217 putative dimer interface [polypeptide binding]; other site 360911000218 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 360911000219 Predicted transcriptional regulator [Transcription]; Region: COG3355 360911000220 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 360911000221 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 360911000222 active site 360911000223 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 360911000224 active site 360911000225 catalytic triad [active] 360911000226 oxyanion hole [active] 360911000227 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911000228 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 360911000229 Walker A/P-loop; other site 360911000230 ATP binding site [chemical binding]; other site 360911000231 Q-loop/lid; other site 360911000232 ABC transporter signature motif; other site 360911000233 Walker B; other site 360911000234 D-loop; other site 360911000235 H-loop/switch region; other site 360911000236 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 360911000237 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 360911000238 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 360911000239 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 360911000240 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 360911000241 active site 360911000242 Zn binding site [ion binding]; other site 360911000243 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 360911000244 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 360911000245 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 360911000246 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 360911000247 bacterial Hfq-like; Region: Hfq; cd01716 360911000248 hexamer interface [polypeptide binding]; other site 360911000249 Sm1 motif; other site 360911000250 RNA binding site [nucleotide binding]; other site 360911000251 Sm2 motif; other site 360911000252 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 360911000253 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 360911000254 generic binding surface I; other site 360911000255 generic binding surface II; other site 360911000256 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911000257 Zn2+ binding site [ion binding]; other site 360911000258 Mg2+ binding site [ion binding]; other site 360911000259 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 360911000260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 360911000261 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 360911000262 5'-3' exonuclease; Region: 53EXOc; smart00475 360911000263 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360911000264 active site 360911000265 metal binding site 1 [ion binding]; metal-binding site 360911000266 putative 5' ssDNA interaction site; other site 360911000267 metal binding site 3; metal-binding site 360911000268 metal binding site 2 [ion binding]; metal-binding site 360911000269 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360911000270 putative DNA binding site [nucleotide binding]; other site 360911000271 putative metal binding site [ion binding]; other site 360911000272 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 360911000273 RNA/DNA hybrid binding site [nucleotide binding]; other site 360911000274 active site 360911000275 fumarate hydratase; Reviewed; Region: fumC; PRK00485 360911000276 Class II fumarases; Region: Fumarase_classII; cd01362 360911000277 active site 360911000278 tetramer interface [polypeptide binding]; other site 360911000279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911000280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911000281 metal binding site [ion binding]; metal-binding site 360911000282 active site 360911000283 I-site; other site 360911000284 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 360911000285 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 360911000286 folate binding site [chemical binding]; other site 360911000287 NADP+ binding site [chemical binding]; other site 360911000288 thymidylate synthase; Reviewed; Region: thyA; PRK01827 360911000289 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 360911000290 dimerization interface [polypeptide binding]; other site 360911000291 active site 360911000292 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 360911000293 intracellular protease, PfpI family; Region: PfpI; TIGR01382 360911000294 proposed catalytic triad [active] 360911000295 conserved cys residue [active] 360911000296 Bax inhibitor 1 like; Region: BaxI_1; cl17691 360911000297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 360911000298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911000299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911000300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911000301 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911000302 Walker A/P-loop; other site 360911000303 ATP binding site [chemical binding]; other site 360911000304 Q-loop/lid; other site 360911000305 ABC transporter signature motif; other site 360911000306 Walker B; other site 360911000307 D-loop; other site 360911000308 H-loop/switch region; other site 360911000309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911000310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911000311 active site 360911000312 catalytic tetrad [active] 360911000313 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 360911000314 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 360911000315 active site 360911000316 dimer interface [polypeptide binding]; other site 360911000317 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 360911000318 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 360911000319 active site 360911000320 FMN binding site [chemical binding]; other site 360911000321 substrate binding site [chemical binding]; other site 360911000322 3Fe-4S cluster binding site [ion binding]; other site 360911000323 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 360911000324 domain interface; other site 360911000325 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 360911000326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911000327 Predicted permease [General function prediction only]; Region: COG2056 360911000328 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 360911000329 hypothetical protein; Provisional; Region: PRK12378 360911000330 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911000331 MarR family; Region: MarR; pfam01047 360911000332 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 360911000333 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 360911000334 putative catalytic cysteine [active] 360911000335 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 360911000336 putative active site [active] 360911000337 metal binding site [ion binding]; metal-binding site 360911000338 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 360911000339 metal binding site [ion binding]; metal-binding site 360911000340 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360911000341 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 360911000342 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 360911000343 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 360911000344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360911000345 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 360911000346 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 360911000347 putative substrate binding site [chemical binding]; other site 360911000348 putative ATP binding site [chemical binding]; other site 360911000349 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 360911000350 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360911000351 active site 360911000352 phosphorylation site [posttranslational modification] 360911000353 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 360911000354 active site 360911000355 P-loop; other site 360911000356 phosphorylation site [posttranslational modification] 360911000357 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 360911000358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911000359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000360 Coenzyme A binding pocket [chemical binding]; other site 360911000361 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911000362 active site 360911000363 metal binding site [ion binding]; metal-binding site 360911000364 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911000365 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 360911000366 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 360911000367 putative nucleotide binding site [chemical binding]; other site 360911000368 uridine monophosphate binding site [chemical binding]; other site 360911000369 homohexameric interface [polypeptide binding]; other site 360911000370 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 360911000371 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 360911000372 putative catalytic residues [active] 360911000373 Cache domain; Region: Cache_1; pfam02743 360911000374 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911000375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911000376 dimerization interface [polypeptide binding]; other site 360911000377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911000378 dimer interface [polypeptide binding]; other site 360911000379 putative CheW interface [polypeptide binding]; other site 360911000380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911000381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 360911000382 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 360911000383 Probable transposase; Region: OrfB_IS605; pfam01385 360911000384 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 360911000385 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 360911000386 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911000387 putative active site [active] 360911000388 catalytic site [active] 360911000389 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911000390 putative active site [active] 360911000391 catalytic site [active] 360911000392 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 360911000393 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911000394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000395 Coenzyme A binding pocket [chemical binding]; other site 360911000396 putative oxidoreductase; Provisional; Region: PRK11579 360911000397 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360911000398 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 360911000399 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911000400 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 360911000401 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 360911000402 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 360911000403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911000404 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 360911000405 Soluble P-type ATPase [General function prediction only]; Region: COG4087 360911000406 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 360911000407 adhesin; Provisional; Region: PRK09752 360911000408 PilZ domain; Region: PilZ; pfam07238 360911000409 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 360911000410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 360911000411 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 360911000412 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 360911000413 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 360911000414 Cation efflux family; Region: Cation_efflux; cl00316 360911000415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911000416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911000417 DNA binding site [nucleotide binding] 360911000418 domain linker motif; other site 360911000419 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 360911000420 dimerization interface [polypeptide binding]; other site 360911000421 ligand binding site [chemical binding]; other site 360911000422 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360911000423 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 360911000424 putative substrate binding site [chemical binding]; other site 360911000425 putative ATP binding site [chemical binding]; other site 360911000426 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 360911000427 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911000428 active site turn [active] 360911000429 phosphorylation site [posttranslational modification] 360911000430 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911000431 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 360911000432 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 360911000433 substrate binding [chemical binding]; other site 360911000434 active site 360911000435 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 360911000436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 360911000437 WYL domain; Region: WYL; pfam13280 360911000438 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 360911000439 Protein of unknown function (DUF817); Region: DUF817; pfam05675 360911000440 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360911000441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 360911000442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000443 dimer interface [polypeptide binding]; other site 360911000444 conserved gate region; other site 360911000445 putative PBP binding loops; other site 360911000446 ABC-ATPase subunit interface; other site 360911000447 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911000448 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 360911000449 putative NAD(P) binding site [chemical binding]; other site 360911000450 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 360911000451 catalytic triad [active] 360911000452 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 360911000453 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911000454 active site 360911000455 metal binding site [ion binding]; metal-binding site 360911000456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911000457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911000458 metal binding site [ion binding]; metal-binding site 360911000459 active site 360911000460 I-site; other site 360911000461 short chain dehydrogenase; Provisional; Region: PRK08309 360911000462 Beta-lactamase; Region: Beta-lactamase; pfam00144 360911000463 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 360911000464 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 360911000465 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911000466 DNA binding residues [nucleotide binding] 360911000467 dimer interface [polypeptide binding]; other site 360911000468 CAAX protease self-immunity; Region: Abi; pfam02517 360911000469 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 360911000470 nudix motif; other site 360911000471 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 360911000472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000473 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911000474 putative substrate translocation pore; other site 360911000475 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 360911000476 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 360911000477 active site 360911000478 Zn binding site [ion binding]; other site 360911000479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911000480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000481 putative substrate translocation pore; other site 360911000482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911000483 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360911000484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911000485 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 360911000486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911000487 non-specific DNA binding site [nucleotide binding]; other site 360911000488 salt bridge; other site 360911000489 sequence-specific DNA binding site [nucleotide binding]; other site 360911000490 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 360911000491 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 360911000492 pentamer interface [polypeptide binding]; other site 360911000493 dodecaamer interface [polypeptide binding]; other site 360911000494 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911000495 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360911000496 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 360911000497 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 360911000498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360911000499 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 360911000500 putative dimerization interface [polypeptide binding]; other site 360911000501 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 360911000502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000503 NAD(P) binding site [chemical binding]; other site 360911000504 active site 360911000505 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 360911000506 Dynamin family; Region: Dynamin_N; pfam00350 360911000507 G1 box; other site 360911000508 GTP/Mg2+ binding site [chemical binding]; other site 360911000509 G2 box; other site 360911000510 Switch I region; other site 360911000511 G3 box; other site 360911000512 Switch II region; other site 360911000513 G4 box; other site 360911000514 G5 box; other site 360911000515 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 360911000516 Dynamin family; Region: Dynamin_N; pfam00350 360911000517 G1 box; other site 360911000518 GTP/Mg2+ binding site [chemical binding]; other site 360911000519 G2 box; other site 360911000520 Switch I region; other site 360911000521 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 360911000522 G3 box; other site 360911000523 Switch II region; other site 360911000524 GTP/Mg2+ binding site [chemical binding]; other site 360911000525 G4 box; other site 360911000526 G5 box; other site 360911000527 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 360911000528 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911000529 NAD binding site [chemical binding]; other site 360911000530 substrate binding site [chemical binding]; other site 360911000531 putative active site [active] 360911000532 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 360911000533 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911000534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911000535 Walker A/P-loop; other site 360911000536 ATP binding site [chemical binding]; other site 360911000537 Q-loop/lid; other site 360911000538 ABC transporter signature motif; other site 360911000539 Walker B; other site 360911000540 D-loop; other site 360911000541 H-loop/switch region; other site 360911000542 Uncharacterized conserved protein [Function unknown]; Region: COG3402 360911000543 Predicted membrane protein [Function unknown]; Region: COG3428 360911000544 Bacterial PH domain; Region: DUF304; pfam03703 360911000545 Bacterial PH domain; Region: DUF304; pfam03703 360911000546 Bacterial PH domain; Region: DUF304; pfam03703 360911000547 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360911000548 DinB family; Region: DinB; cl17821 360911000549 DinB superfamily; Region: DinB_2; pfam12867 360911000550 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 360911000551 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911000552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000553 Walker A motif; other site 360911000554 ATP binding site [chemical binding]; other site 360911000555 Walker B motif; other site 360911000556 arginine finger; other site 360911000557 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911000558 Protein of unknown function DUF58; Region: DUF58; pfam01882 360911000559 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 360911000560 nudix motif; other site 360911000561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911000562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911000563 DNA-binding site [nucleotide binding]; DNA binding site 360911000564 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 360911000565 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911000566 beta-galactosidase; Region: BGL; TIGR03356 360911000567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 360911000568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911000569 dimerization interface [polypeptide binding]; other site 360911000570 putative DNA binding site [nucleotide binding]; other site 360911000571 putative Zn2+ binding site [ion binding]; other site 360911000572 short chain dehydrogenase; Provisional; Region: PRK06179 360911000573 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 360911000574 NADP binding site [chemical binding]; other site 360911000575 active site 360911000576 steroid binding site; other site 360911000577 Excalibur calcium-binding domain; Region: Excalibur; cl05460 360911000578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911000579 dimerization interface [polypeptide binding]; other site 360911000580 putative DNA binding site [nucleotide binding]; other site 360911000581 putative Zn2+ binding site [ion binding]; other site 360911000582 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360911000583 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000584 PGAP1-like protein; Region: PGAP1; pfam07819 360911000585 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 360911000586 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 360911000587 classical (c) SDRs; Region: SDR_c; cd05233 360911000588 NAD(P) binding site [chemical binding]; other site 360911000589 active site 360911000590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360911000591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911000592 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 360911000593 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911000594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911000595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 360911000596 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911000597 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360911000598 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 360911000599 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911000600 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911000601 putative active site [active] 360911000602 catalytic site [active] 360911000603 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911000604 putative active site [active] 360911000605 catalytic site [active] 360911000606 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911000607 Protein of unknown function DUF58; Region: DUF58; pfam01882 360911000608 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911000609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000610 Walker A motif; other site 360911000611 ATP binding site [chemical binding]; other site 360911000612 Walker B motif; other site 360911000613 arginine finger; other site 360911000614 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360911000615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000616 dimer interface [polypeptide binding]; other site 360911000617 conserved gate region; other site 360911000618 putative PBP binding loops; other site 360911000619 ABC-ATPase subunit interface; other site 360911000620 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911000621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911000622 substrate binding pocket [chemical binding]; other site 360911000623 membrane-bound complex binding site; other site 360911000624 hinge residues; other site 360911000625 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911000626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000627 Coenzyme A binding pocket [chemical binding]; other site 360911000628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000629 Coenzyme A binding pocket [chemical binding]; other site 360911000630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 360911000631 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 360911000632 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 360911000633 nudix motif; other site 360911000634 DinB superfamily; Region: DinB_2; pfam12867 360911000635 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 360911000636 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 360911000637 CAP-like domain; other site 360911000638 active site 360911000639 primary dimer interface [polypeptide binding]; other site 360911000640 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911000641 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911000642 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911000643 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 360911000644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911000645 ATP binding site [chemical binding]; other site 360911000646 Mg2+ binding site [ion binding]; other site 360911000647 G-X-G motif; other site 360911000648 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 360911000649 anchoring element; other site 360911000650 dimer interface [polypeptide binding]; other site 360911000651 ATP binding site [chemical binding]; other site 360911000652 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 360911000653 active site 360911000654 putative metal-binding site [ion binding]; other site 360911000655 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 360911000656 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 360911000657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911000658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911000659 metal binding site [ion binding]; metal-binding site 360911000660 active site 360911000661 I-site; other site 360911000662 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 360911000663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911000664 active site 360911000665 DNA binding site [nucleotide binding] 360911000666 Int/Topo IB signature motif; other site 360911000667 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 360911000668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000670 homodimer interface [polypeptide binding]; other site 360911000671 catalytic residue [active] 360911000672 Protein of unknown function DUF45; Region: DUF45; pfam01863 360911000673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911000674 PAS domain; Region: PAS_9; pfam13426 360911000675 putative active site [active] 360911000676 heme pocket [chemical binding]; other site 360911000677 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911000678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911000679 dimer interface [polypeptide binding]; other site 360911000680 putative CheW interface [polypeptide binding]; other site 360911000681 Domain of unknown function DUF302; Region: DUF302; cl01364 360911000682 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 360911000683 ArsC family; Region: ArsC; pfam03960 360911000684 putative catalytic residues [active] 360911000685 thiol/disulfide switch; other site 360911000686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911000687 ABC-ATPase subunit interface; other site 360911000688 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 360911000689 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 360911000690 Walker A/P-loop; other site 360911000691 ATP binding site [chemical binding]; other site 360911000692 Q-loop/lid; other site 360911000693 ABC transporter signature motif; other site 360911000694 Walker B; other site 360911000695 D-loop; other site 360911000696 H-loop/switch region; other site 360911000697 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 360911000698 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 360911000699 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 360911000700 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 360911000701 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 360911000702 putative active site [active] 360911000703 metal binding site [ion binding]; metal-binding site 360911000704 transaminase; Reviewed; Region: PRK08068 360911000705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911000706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911000707 homodimer interface [polypeptide binding]; other site 360911000708 catalytic residue [active] 360911000709 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 360911000710 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911000713 putative substrate translocation pore; other site 360911000714 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 360911000715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911000716 putative substrate translocation pore; other site 360911000717 POT family; Region: PTR2; pfam00854 360911000718 glutamine synthetase, type I; Region: GlnA; TIGR00653 360911000719 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 360911000720 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 360911000721 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 360911000722 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360911000723 putative NAD(P) binding site [chemical binding]; other site 360911000724 active site 360911000725 putative substrate binding site [chemical binding]; other site 360911000726 Heat induced stress protein YflT; Region: YflT; pfam11181 360911000727 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911000728 synthetase active site [active] 360911000729 NTP binding site [chemical binding]; other site 360911000730 metal binding site [ion binding]; metal-binding site 360911000731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911000732 MarR family; Region: MarR_2; cl17246 360911000733 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 360911000734 active site 360911000735 putative catalytic site [active] 360911000736 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 360911000737 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 360911000738 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 360911000739 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 360911000740 active site 360911000741 catalytic site [active] 360911000742 metal binding site [ion binding]; metal-binding site 360911000743 dimer interface [polypeptide binding]; other site 360911000744 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 360911000745 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 360911000746 active site 360911000747 Zn binding site [ion binding]; other site 360911000748 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 360911000749 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 360911000750 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 360911000751 [2Fe-2S] cluster binding site [ion binding]; other site 360911000752 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 360911000753 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 360911000754 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360911000755 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 360911000756 Na binding site [ion binding]; other site 360911000757 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 360911000758 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911000759 amino acid carrier protein; Region: agcS; TIGR00835 360911000760 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911000761 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360911000762 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 360911000763 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 360911000764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911000765 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 360911000766 active site 360911000767 catalytic residues [active] 360911000768 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 360911000769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911000770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911000771 active site 360911000772 phosphorylation site [posttranslational modification] 360911000773 intermolecular recognition site; other site 360911000774 dimerization interface [polypeptide binding]; other site 360911000775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911000776 DNA binding site [nucleotide binding] 360911000777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911000778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911000779 dimerization interface [polypeptide binding]; other site 360911000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911000781 dimer interface [polypeptide binding]; other site 360911000782 phosphorylation site [posttranslational modification] 360911000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911000784 ATP binding site [chemical binding]; other site 360911000785 Mg2+ binding site [ion binding]; other site 360911000786 G-X-G motif; other site 360911000787 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 360911000788 FtsX-like permease family; Region: FtsX; pfam02687 360911000789 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911000790 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360911000791 Walker A/P-loop; other site 360911000792 ATP binding site [chemical binding]; other site 360911000793 Q-loop/lid; other site 360911000794 ABC transporter signature motif; other site 360911000795 Walker B; other site 360911000796 D-loop; other site 360911000797 H-loop/switch region; other site 360911000798 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360911000799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000800 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360911000801 CAAX protease self-immunity; Region: Abi; pfam02517 360911000802 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360911000803 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360911000804 catalytic residue [active] 360911000805 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 360911000806 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911000807 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 360911000808 Walker A/P-loop; other site 360911000809 ATP binding site [chemical binding]; other site 360911000810 Q-loop/lid; other site 360911000811 ABC transporter signature motif; other site 360911000812 Walker B; other site 360911000813 D-loop; other site 360911000814 H-loop/switch region; other site 360911000815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911000816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911000817 Walker A/P-loop; other site 360911000818 ATP binding site [chemical binding]; other site 360911000819 Q-loop/lid; other site 360911000820 ABC transporter signature motif; other site 360911000821 Walker B; other site 360911000822 D-loop; other site 360911000823 H-loop/switch region; other site 360911000824 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 360911000825 YKOF-related Family; Region: Ykof; pfam07615 360911000826 YKOF-related Family; Region: Ykof; pfam07615 360911000827 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 360911000828 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 360911000829 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 360911000830 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 360911000831 Strictosidine synthase; Region: Str_synth; pfam03088 360911000832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 360911000833 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 360911000834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911000835 FeS/SAM binding site; other site 360911000836 amidase; Provisional; Region: PRK06828 360911000837 Amidase; Region: Amidase; cl11426 360911000838 methionine sulfoxide reductase A; Provisional; Region: PRK14054 360911000839 Electron transfer DM13; Region: DM13; pfam10517 360911000840 acyl-CoA synthetase; Validated; Region: PRK07788 360911000841 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360911000842 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360911000843 active site 360911000844 CoA binding site [chemical binding]; other site 360911000845 AMP binding site [chemical binding]; other site 360911000846 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 360911000847 classical (c) SDRs; Region: SDR_c; cd05233 360911000848 NAD(P) binding site [chemical binding]; other site 360911000849 active site 360911000850 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 360911000851 putative hydrophobic ligand binding site [chemical binding]; other site 360911000852 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 360911000853 EamA-like transporter family; Region: EamA; cl17759 360911000854 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 360911000855 dimerization interface [polypeptide binding]; other site 360911000856 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 360911000857 active site 360911000858 catalytic site [active] 360911000859 substrate binding site [chemical binding]; other site 360911000860 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911000861 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 360911000862 Ligand binding site; other site 360911000863 Putative Catalytic site; other site 360911000864 DXD motif; other site 360911000865 GtrA-like protein; Region: GtrA; pfam04138 360911000866 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 360911000867 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360911000868 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360911000869 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 360911000870 HD domain; Region: HD_4; pfam13328 360911000871 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 360911000872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911000873 NAD(P) binding site [chemical binding]; other site 360911000874 active site 360911000875 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 360911000876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911000877 Coenzyme A binding pocket [chemical binding]; other site 360911000878 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 360911000879 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 360911000880 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911000881 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911000882 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 360911000883 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360911000884 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 360911000885 Na binding site [ion binding]; other site 360911000886 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 360911000887 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 360911000888 putative active site [active] 360911000889 putative metal binding site [ion binding]; other site 360911000890 argininosuccinate synthase; Provisional; Region: PRK13820 360911000891 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 360911000892 ANP binding site [chemical binding]; other site 360911000893 Substrate Binding Site II [chemical binding]; other site 360911000894 Substrate Binding Site I [chemical binding]; other site 360911000895 argininosuccinate lyase; Provisional; Region: PRK00855 360911000896 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 360911000897 active sites [active] 360911000898 tetramer interface [polypeptide binding]; other site 360911000899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911000900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911000901 BioY family; Region: BioY; pfam02632 360911000902 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 360911000903 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360911000904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911000905 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360911000906 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 360911000907 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 360911000908 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 360911000909 Walker A/P-loop; other site 360911000910 ATP binding site [chemical binding]; other site 360911000911 Q-loop/lid; other site 360911000912 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 360911000913 ABC transporter signature motif; other site 360911000914 Walker B; other site 360911000915 D-loop; other site 360911000916 H-loop/switch region; other site 360911000917 exonuclease subunit SbcD; Provisional; Region: PRK10966 360911000918 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 360911000919 active site 360911000920 metal binding site [ion binding]; metal-binding site 360911000921 DNA binding site [nucleotide binding] 360911000922 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 360911000923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911000924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911000925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911000926 Walker A/P-loop; other site 360911000927 ATP binding site [chemical binding]; other site 360911000928 Q-loop/lid; other site 360911000929 ABC transporter signature motif; other site 360911000930 Walker B; other site 360911000931 D-loop; other site 360911000932 H-loop/switch region; other site 360911000933 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 360911000934 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 360911000935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 360911000936 Protein of unknown function (DUF975); Region: DUF975; cl10504 360911000937 CutC family; Region: CutC; cl01218 360911000938 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360911000939 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 360911000940 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360911000941 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 360911000942 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 360911000943 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 360911000944 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 360911000945 active site 360911000946 stage V sporulation protein K; Region: spore_V_K; TIGR02881 360911000947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000948 Walker A motif; other site 360911000949 ATP binding site [chemical binding]; other site 360911000950 Walker B motif; other site 360911000951 arginine finger; other site 360911000952 stage V sporulation protein K; Region: spore_V_K; TIGR02881 360911000953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911000954 Walker A motif; other site 360911000955 ATP binding site [chemical binding]; other site 360911000956 Walker B motif; other site 360911000957 arginine finger; other site 360911000958 BCCT family transporter; Region: BCCT; pfam02028 360911000959 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 360911000960 aconitate hydratase; Validated; Region: PRK09277 360911000961 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 360911000962 substrate binding site [chemical binding]; other site 360911000963 ligand binding site [chemical binding]; other site 360911000964 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 360911000965 substrate binding site [chemical binding]; other site 360911000966 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 360911000967 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 360911000968 G1 box; other site 360911000969 putative GEF interaction site [polypeptide binding]; other site 360911000970 GTP/Mg2+ binding site [chemical binding]; other site 360911000971 Switch I region; other site 360911000972 G2 box; other site 360911000973 G3 box; other site 360911000974 Switch II region; other site 360911000975 G4 box; other site 360911000976 G5 box; other site 360911000977 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 360911000978 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 360911000979 Protein of unknown function, DUF485; Region: DUF485; pfam04341 360911000980 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360911000981 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 360911000982 Na binding site [ion binding]; other site 360911000983 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 360911000984 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 360911000985 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 360911000986 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 360911000987 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911000988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911000989 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 360911000990 Walker A/P-loop; other site 360911000991 ATP binding site [chemical binding]; other site 360911000992 Q-loop/lid; other site 360911000993 ABC transporter signature motif; other site 360911000994 Walker B; other site 360911000995 D-loop; other site 360911000996 H-loop/switch region; other site 360911000997 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911000998 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 360911000999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911001000 Walker A/P-loop; other site 360911001001 ATP binding site [chemical binding]; other site 360911001002 Q-loop/lid; other site 360911001003 ABC transporter signature motif; other site 360911001004 Walker B; other site 360911001005 D-loop; other site 360911001006 H-loop/switch region; other site 360911001007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 360911001008 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 360911001009 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 360911001010 TPP-binding site [chemical binding]; other site 360911001011 dimer interface [polypeptide binding]; other site 360911001012 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360911001013 PYR/PP interface [polypeptide binding]; other site 360911001014 dimer interface [polypeptide binding]; other site 360911001015 TPP binding site [chemical binding]; other site 360911001016 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911001017 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 360911001018 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 360911001019 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 360911001020 catalytic residues [active] 360911001021 catalytic nucleophile [active] 360911001022 LexA repressor; Validated; Region: PRK00215 360911001023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911001024 putative DNA binding site [nucleotide binding]; other site 360911001025 putative Zn2+ binding site [ion binding]; other site 360911001026 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 360911001027 Catalytic site [active] 360911001028 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 360911001029 Helix-turn-helix domain; Region: HTH_18; pfam12833 360911001030 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 360911001031 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 360911001032 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 360911001033 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 360911001034 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 360911001035 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911001036 DNA binding residues [nucleotide binding] 360911001037 putative dimer interface [polypeptide binding]; other site 360911001038 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 360911001039 Aluminium resistance protein; Region: Alum_res; pfam06838 360911001040 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 360911001041 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 360911001042 HflX GTPase family; Region: HflX; cd01878 360911001043 G1 box; other site 360911001044 GTP/Mg2+ binding site [chemical binding]; other site 360911001045 Switch I region; other site 360911001046 G2 box; other site 360911001047 G3 box; other site 360911001048 Switch II region; other site 360911001049 G4 box; other site 360911001050 G5 box; other site 360911001051 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911001052 active site 360911001053 Int/Topo IB signature motif; other site 360911001054 DNA binding site [nucleotide binding] 360911001055 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 360911001056 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 360911001057 active site 360911001058 HIGH motif; other site 360911001059 KMSKS motif; other site 360911001060 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 360911001061 tRNA binding surface [nucleotide binding]; other site 360911001062 anticodon binding site; other site 360911001063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360911001064 catalytic core [active] 360911001065 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911001066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 360911001067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911001068 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911001069 putative substrate translocation pore; other site 360911001070 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 360911001071 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 360911001072 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 360911001073 substrate-cofactor binding pocket; other site 360911001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001075 catalytic residue [active] 360911001076 Threonine dehydrogenase; Region: TDH; cd05281 360911001077 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 360911001078 structural Zn binding site [ion binding]; other site 360911001079 catalytic Zn binding site [ion binding]; other site 360911001080 tetramer interface [polypeptide binding]; other site 360911001081 NADP binding site [chemical binding]; other site 360911001082 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 360911001083 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 360911001084 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911001085 putative active site [active] 360911001086 metal binding site [ion binding]; metal-binding site 360911001087 homodimer binding site [polypeptide binding]; other site 360911001088 phosphodiesterase; Provisional; Region: PRK12704 360911001089 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911001090 Zn2+ binding site [ion binding]; other site 360911001091 Mg2+ binding site [ion binding]; other site 360911001092 recombinase A; Provisional; Region: recA; PRK09354 360911001093 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 360911001094 hexamer interface [polypeptide binding]; other site 360911001095 Walker A motif; other site 360911001096 ATP binding site [chemical binding]; other site 360911001097 Walker B motif; other site 360911001098 competence damage-inducible protein A; Provisional; Region: PRK00549 360911001099 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 360911001100 putative MPT binding site; other site 360911001101 Competence-damaged protein; Region: CinA; pfam02464 360911001102 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 360911001103 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 360911001104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911001105 non-specific DNA binding site [nucleotide binding]; other site 360911001106 salt bridge; other site 360911001107 sequence-specific DNA binding site [nucleotide binding]; other site 360911001108 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 360911001109 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 360911001110 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 360911001111 classical (c) SDRs; Region: SDR_c; cd05233 360911001112 NAD(P) binding site [chemical binding]; other site 360911001113 active site 360911001114 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360911001115 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 360911001116 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360911001117 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360911001118 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360911001119 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 360911001120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 360911001121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911001122 dimerization interface [polypeptide binding]; other site 360911001123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911001124 dimer interface [polypeptide binding]; other site 360911001125 phosphorylation site [posttranslational modification] 360911001126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911001127 ATP binding site [chemical binding]; other site 360911001128 Mg2+ binding site [ion binding]; other site 360911001129 G-X-G motif; other site 360911001130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911001131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001132 active site 360911001133 phosphorylation site [posttranslational modification] 360911001134 intermolecular recognition site; other site 360911001135 dimerization interface [polypeptide binding]; other site 360911001136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911001137 DNA binding site [nucleotide binding] 360911001138 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 360911001139 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 360911001140 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 360911001141 ResB-like family; Region: ResB; pfam05140 360911001142 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 360911001143 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360911001144 catalytic residues [active] 360911001145 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 360911001146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911001147 RNA binding surface [nucleotide binding]; other site 360911001148 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 360911001149 active site 360911001150 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 360911001151 ScpA/B protein; Region: ScpA_ScpB; cl00598 360911001152 Domain of unknown function (DUF309); Region: DUF309; pfam03745 360911001153 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 360911001154 active site 360911001155 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 360911001156 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360911001157 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360911001158 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 360911001159 purine nucleoside phosphorylase; Provisional; Region: PRK08202 360911001160 phosphopentomutase; Provisional; Region: PRK05362 360911001161 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 360911001162 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 360911001163 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 360911001164 active site 360911001165 Int/Topo IB signature motif; other site 360911001166 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 360911001167 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 360911001168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911001169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911001170 putative substrate translocation pore; other site 360911001171 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 360911001172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911001173 putative metal binding site [ion binding]; other site 360911001174 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360911001175 metal binding site 2 [ion binding]; metal-binding site 360911001176 putative DNA binding helix; other site 360911001177 metal binding site 1 [ion binding]; metal-binding site 360911001178 dimer interface [polypeptide binding]; other site 360911001179 structural Zn2+ binding site [ion binding]; other site 360911001180 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 360911001181 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 360911001182 dimer interface [polypeptide binding]; other site 360911001183 ADP-ribose binding site [chemical binding]; other site 360911001184 active site 360911001185 nudix motif; other site 360911001186 metal binding site [ion binding]; metal-binding site 360911001187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911001188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911001189 active site 360911001190 catalytic tetrad [active] 360911001191 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911001192 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 360911001193 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 360911001194 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911001195 catalytic residues [active] 360911001196 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 360911001197 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 360911001198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911001199 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 360911001200 Walker A/P-loop; other site 360911001201 ATP binding site [chemical binding]; other site 360911001202 Q-loop/lid; other site 360911001203 ABC transporter signature motif; other site 360911001204 Walker B; other site 360911001205 D-loop; other site 360911001206 H-loop/switch region; other site 360911001207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001208 dimer interface [polypeptide binding]; other site 360911001209 conserved gate region; other site 360911001210 putative PBP binding loops; other site 360911001211 ABC-ATPase subunit interface; other site 360911001212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001213 dimer interface [polypeptide binding]; other site 360911001214 conserved gate region; other site 360911001215 putative PBP binding loops; other site 360911001216 ABC-ATPase subunit interface; other site 360911001217 hypothetical protein; Provisional; Region: PRK11622 360911001218 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 360911001219 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 360911001220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911001221 NAD(P) binding site [chemical binding]; other site 360911001222 active site 360911001223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 360911001224 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 360911001225 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 360911001226 tetrameric interface [polypeptide binding]; other site 360911001227 activator binding site; other site 360911001228 NADP binding site [chemical binding]; other site 360911001229 substrate binding site [chemical binding]; other site 360911001230 catalytic residues [active] 360911001231 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 360911001232 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 360911001233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001234 active site 360911001235 phosphorylation site [posttranslational modification] 360911001236 intermolecular recognition site; other site 360911001237 dimerization interface [polypeptide binding]; other site 360911001238 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 360911001239 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 360911001240 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 360911001241 Cl binding site [ion binding]; other site 360911001242 oligomer interface [polypeptide binding]; other site 360911001243 Response regulator receiver domain; Region: Response_reg; pfam00072 360911001244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001245 active site 360911001246 phosphorylation site [posttranslational modification] 360911001247 intermolecular recognition site; other site 360911001248 dimerization interface [polypeptide binding]; other site 360911001249 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 360911001250 DNA topoisomerase III; Provisional; Region: PRK07726 360911001251 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 360911001252 active site 360911001253 putative interdomain interaction site [polypeptide binding]; other site 360911001254 putative metal-binding site [ion binding]; other site 360911001255 putative nucleotide binding site [chemical binding]; other site 360911001256 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 360911001257 domain I; other site 360911001258 DNA binding groove [nucleotide binding] 360911001259 phosphate binding site [ion binding]; other site 360911001260 domain II; other site 360911001261 domain III; other site 360911001262 nucleotide binding site [chemical binding]; other site 360911001263 catalytic site [active] 360911001264 domain IV; other site 360911001265 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911001266 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 360911001267 EamA-like transporter family; Region: EamA; cl17759 360911001268 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 360911001269 EamA-like transporter family; Region: EamA; pfam00892 360911001270 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 360911001271 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 360911001272 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 360911001273 Peptidase family U32; Region: Peptidase_U32; pfam01136 360911001274 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 360911001275 Peptidase family U32; Region: Peptidase_U32; pfam01136 360911001276 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 360911001277 classical (c) SDRs; Region: SDR_c; cd05233 360911001278 NAD(P) binding site [chemical binding]; other site 360911001279 active site 360911001280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911001281 ABC transporter signature motif; other site 360911001282 Walker B; other site 360911001283 D-loop; other site 360911001284 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911001285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911001286 Walker A/P-loop; other site 360911001287 ATP binding site [chemical binding]; other site 360911001288 Q-loop/lid; other site 360911001289 Walker B; other site 360911001290 D-loop; other site 360911001291 H-loop/switch region; other site 360911001292 ribonuclease Z; Region: RNase_Z; TIGR02651 360911001293 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 360911001294 peptidase T-like protein; Region: PepT-like; TIGR01883 360911001295 metal binding site [ion binding]; metal-binding site 360911001296 putative dimer interface [polypeptide binding]; other site 360911001297 Predicted membrane protein [Function unknown]; Region: COG4129 360911001298 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 360911001299 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 360911001300 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 360911001301 short chain dehydrogenase; Provisional; Region: PRK07677 360911001302 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 360911001303 NAD(P) binding site [chemical binding]; other site 360911001304 substrate binding site [chemical binding]; other site 360911001305 homotetramer interface [polypeptide binding]; other site 360911001306 active site 360911001307 homodimer interface [polypeptide binding]; other site 360911001308 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 360911001309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911001310 Zn2+ binding site [ion binding]; other site 360911001311 Mg2+ binding site [ion binding]; other site 360911001312 metal-dependent hydrolase; Provisional; Region: PRK00685 360911001313 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 360911001314 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 360911001315 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 360911001316 Walker A/P-loop; other site 360911001317 ATP binding site [chemical binding]; other site 360911001318 Q-loop/lid; other site 360911001319 ABC transporter signature motif; other site 360911001320 Walker B; other site 360911001321 D-loop; other site 360911001322 H-loop/switch region; other site 360911001323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360911001324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001325 dimer interface [polypeptide binding]; other site 360911001326 conserved gate region; other site 360911001327 putative PBP binding loops; other site 360911001328 ABC-ATPase subunit interface; other site 360911001329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911001330 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911001331 substrate binding pocket [chemical binding]; other site 360911001332 membrane-bound complex binding site; other site 360911001333 hinge residues; other site 360911001334 Protein of unknown function (DUF952); Region: DUF952; cl01393 360911001335 Disulphide isomerase; Region: Disulph_isomer; pfam06491 360911001336 Methyltransferase domain; Region: Methyltransf_31; pfam13847 360911001337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001338 S-adenosylmethionine binding site [chemical binding]; other site 360911001339 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 360911001340 SpoOM protein; Region: Spo0M; pfam07070 360911001341 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 360911001342 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360911001343 E3 interaction surface; other site 360911001344 lipoyl attachment site [posttranslational modification]; other site 360911001345 e3 binding domain; Region: E3_binding; pfam02817 360911001346 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 360911001347 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 360911001348 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 360911001349 alpha subunit interface [polypeptide binding]; other site 360911001350 TPP binding site [chemical binding]; other site 360911001351 heterodimer interface [polypeptide binding]; other site 360911001352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911001353 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 360911001354 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 360911001355 tetramer interface [polypeptide binding]; other site 360911001356 TPP-binding site [chemical binding]; other site 360911001357 heterodimer interface [polypeptide binding]; other site 360911001358 phosphorylation loop region [posttranslational modification] 360911001359 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 360911001360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911001361 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911001362 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360911001363 nucleotide binding site [chemical binding]; other site 360911001364 Acetokinase family; Region: Acetate_kinase; cl17229 360911001365 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 360911001366 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 360911001367 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 360911001368 NAD binding site [chemical binding]; other site 360911001369 Phe binding site; other site 360911001370 phosphate butyryltransferase; Validated; Region: PRK07742 360911001371 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360911001372 PAS domain S-box; Region: sensory_box; TIGR00229 360911001373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911001374 putative active site [active] 360911001375 heme pocket [chemical binding]; other site 360911001376 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 360911001377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911001378 Walker A motif; other site 360911001379 ATP binding site [chemical binding]; other site 360911001380 Walker B motif; other site 360911001381 arginine finger; other site 360911001382 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 360911001383 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 360911001384 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 360911001385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001386 active site 360911001387 phosphorylation site [posttranslational modification] 360911001388 intermolecular recognition site; other site 360911001389 dimerization interface [polypeptide binding]; other site 360911001390 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 360911001391 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 360911001392 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 360911001393 Walker A/P-loop; other site 360911001394 ATP binding site [chemical binding]; other site 360911001395 Q-loop/lid; other site 360911001396 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 360911001397 ABC transporter signature motif; other site 360911001398 Walker B; other site 360911001399 D-loop; other site 360911001400 H-loop/switch region; other site 360911001401 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 360911001402 arginine repressor; Provisional; Region: PRK04280 360911001403 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 360911001404 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 360911001405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911001406 RNA binding surface [nucleotide binding]; other site 360911001407 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 360911001408 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 360911001409 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 360911001410 TPP-binding site; other site 360911001411 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360911001412 PYR/PP interface [polypeptide binding]; other site 360911001413 dimer interface [polypeptide binding]; other site 360911001414 TPP binding site [chemical binding]; other site 360911001415 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911001416 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 360911001417 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 360911001418 substrate binding pocket [chemical binding]; other site 360911001419 chain length determination region; other site 360911001420 substrate-Mg2+ binding site; other site 360911001421 catalytic residues [active] 360911001422 aspartate-rich region 1; other site 360911001423 active site lid residues [active] 360911001424 aspartate-rich region 2; other site 360911001425 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 360911001426 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 360911001427 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 360911001428 generic binding surface II; other site 360911001429 generic binding surface I; other site 360911001430 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 360911001431 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 360911001432 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 360911001433 homodimer interface [polypeptide binding]; other site 360911001434 NADP binding site [chemical binding]; other site 360911001435 substrate binding site [chemical binding]; other site 360911001436 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 360911001437 putative RNA binding site [nucleotide binding]; other site 360911001438 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 360911001439 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911001440 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911001441 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 360911001442 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 360911001443 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 360911001444 carboxyltransferase (CT) interaction site; other site 360911001445 biotinylation site [posttranslational modification]; other site 360911001446 elongation factor P; Validated; Region: PRK00529 360911001447 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 360911001448 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 360911001449 RNA binding site [nucleotide binding]; other site 360911001450 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 360911001451 RNA binding site [nucleotide binding]; other site 360911001452 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 360911001453 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360911001454 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 360911001455 active site 360911001456 Dehydroquinase class II; Region: DHquinase_II; pfam01220 360911001457 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 360911001458 active site 360911001459 trimer interface [polypeptide binding]; other site 360911001460 dimer interface [polypeptide binding]; other site 360911001461 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 360911001462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911001463 active site 360911001464 manganese transport transcriptional regulator; Provisional; Region: PRK03902 360911001465 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 360911001466 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 360911001467 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911001468 active site residue [active] 360911001469 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 360911001470 tetramer interface [polypeptide binding]; other site 360911001471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001472 catalytic residue [active] 360911001473 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 360911001474 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 360911001475 tetramer interface [polypeptide binding]; other site 360911001476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001477 catalytic residue [active] 360911001478 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 360911001479 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 360911001480 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 360911001481 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 360911001482 shikimate kinase; Reviewed; Region: aroK; PRK00131 360911001483 ADP binding site [chemical binding]; other site 360911001484 magnesium binding site [ion binding]; other site 360911001485 putative shikimate binding site; other site 360911001486 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 360911001487 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360911001488 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360911001489 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360911001490 Walker A motif; other site 360911001491 ATP binding site [chemical binding]; other site 360911001492 Walker B motif; other site 360911001493 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 360911001494 ArsC family; Region: ArsC; pfam03960 360911001495 putative catalytic residues [active] 360911001496 thiol/disulfide switch; other site 360911001497 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 360911001498 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 360911001499 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 360911001500 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 360911001501 Sulfatase; Region: Sulfatase; pfam00884 360911001502 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 360911001503 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360911001504 nucleotide binding site [chemical binding]; other site 360911001505 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 360911001506 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 360911001507 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 360911001508 putative oligomer interface [polypeptide binding]; other site 360911001509 putative active site [active] 360911001510 metal binding site [ion binding]; metal-binding site 360911001511 Rhomboid family; Region: Rhomboid; pfam01694 360911001512 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 360911001513 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 360911001514 dimer interface [polypeptide binding]; other site 360911001515 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911001516 NAD binding site [chemical binding]; other site 360911001517 substrate binding site [chemical binding]; other site 360911001518 Integral membrane protein DUF92; Region: DUF92; pfam01940 360911001519 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 360911001520 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 360911001521 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 360911001522 Uncharacterized conserved protein [Function unknown]; Region: COG1543 360911001523 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 360911001524 active site 360911001525 substrate binding site [chemical binding]; other site 360911001526 catalytic site [active] 360911001527 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 360911001528 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911001529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 360911001530 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 360911001531 PhoU domain; Region: PhoU; pfam01895 360911001532 PhoU domain; Region: PhoU; pfam01895 360911001533 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 360911001534 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 360911001535 Walker A/P-loop; other site 360911001536 ATP binding site [chemical binding]; other site 360911001537 Q-loop/lid; other site 360911001538 ABC transporter signature motif; other site 360911001539 Walker B; other site 360911001540 D-loop; other site 360911001541 H-loop/switch region; other site 360911001542 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 360911001543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001544 dimer interface [polypeptide binding]; other site 360911001545 conserved gate region; other site 360911001546 putative PBP binding loops; other site 360911001547 ABC-ATPase subunit interface; other site 360911001548 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 360911001549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911001550 dimer interface [polypeptide binding]; other site 360911001551 conserved gate region; other site 360911001552 putative PBP binding loops; other site 360911001553 ABC-ATPase subunit interface; other site 360911001554 PBP superfamily domain; Region: PBP_like_2; cl17296 360911001555 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 360911001556 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360911001557 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360911001558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 360911001559 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 360911001560 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 360911001561 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 360911001562 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 360911001563 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 360911001564 active site 360911001565 Na/Ca binding site [ion binding]; other site 360911001566 catalytic site [active] 360911001567 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 360911001568 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911001569 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911001570 PhoU domain; Region: PhoU; pfam01895 360911001571 PhoU domain; Region: PhoU; pfam01895 360911001572 HAMP domain; Region: HAMP; pfam00672 360911001573 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911001574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911001575 dimer interface [polypeptide binding]; other site 360911001576 putative CheW interface [polypeptide binding]; other site 360911001577 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 360911001578 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 360911001579 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 360911001580 Uncharacterized conserved protein [Function unknown]; Region: COG5663 360911001581 putative carbohydrate kinase; Provisional; Region: PRK10565 360911001582 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 360911001583 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 360911001584 putative substrate binding site [chemical binding]; other site 360911001585 putative ATP binding site [chemical binding]; other site 360911001586 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360911001587 metal binding site 2 [ion binding]; metal-binding site 360911001588 putative DNA binding helix; other site 360911001589 metal binding site 1 [ion binding]; metal-binding site 360911001590 dimer interface [polypeptide binding]; other site 360911001591 structural Zn2+ binding site [ion binding]; other site 360911001592 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 360911001593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911001594 ABC-ATPase subunit interface; other site 360911001595 dimer interface [polypeptide binding]; other site 360911001596 putative PBP binding regions; other site 360911001597 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911001598 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 360911001599 exopolyphosphatase; Region: exo_poly_only; TIGR03706 360911001600 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 360911001601 polyphosphate kinase; Provisional; Region: PRK05443 360911001602 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 360911001603 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 360911001604 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 360911001605 putative domain interface [polypeptide binding]; other site 360911001606 putative active site [active] 360911001607 catalytic site [active] 360911001608 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 360911001609 putative domain interface [polypeptide binding]; other site 360911001610 putative active site [active] 360911001611 catalytic site [active] 360911001612 endonuclease IV; Provisional; Region: PRK01060 360911001613 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 360911001614 AP (apurinic/apyrimidinic) site pocket; other site 360911001615 DNA interaction; other site 360911001616 Metal-binding active site; metal-binding site 360911001617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911001618 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360911001619 ATP binding site [chemical binding]; other site 360911001620 Mg++ binding site [ion binding]; other site 360911001621 motif III; other site 360911001622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911001623 nucleotide binding region [chemical binding]; other site 360911001624 ATP-binding site [chemical binding]; other site 360911001625 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 360911001626 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360911001627 ligand binding site [chemical binding]; other site 360911001628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911001629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911001630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911001631 dimer interface [polypeptide binding]; other site 360911001632 phosphorylation site [posttranslational modification] 360911001633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911001634 ATP binding site [chemical binding]; other site 360911001635 Mg2+ binding site [ion binding]; other site 360911001636 G-X-G motif; other site 360911001637 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 360911001638 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 360911001639 Uncharacterized conserved protein [Function unknown]; Region: COG0327 360911001640 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 360911001641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 360911001642 Uncharacterized conserved protein [Function unknown]; Region: COG0327 360911001643 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 360911001644 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 360911001645 Family of unknown function (DUF633); Region: DUF633; pfam04816 360911001646 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 360911001647 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 360911001648 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 360911001649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911001650 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360911001651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911001652 DNA binding residues [nucleotide binding] 360911001653 DNA primase; Validated; Region: dnaG; PRK05667 360911001654 CHC2 zinc finger; Region: zf-CHC2; pfam01807 360911001655 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 360911001656 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 360911001657 active site 360911001658 metal binding site [ion binding]; metal-binding site 360911001659 interdomain interaction site; other site 360911001660 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 360911001661 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 360911001662 HTH domain; Region: HTH_11; pfam08279 360911001663 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 360911001664 FOG: CBS domain [General function prediction only]; Region: COG0517 360911001665 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 360911001666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 360911001667 DALR anticodon binding domain; Region: DALR_1; pfam05746 360911001668 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 360911001669 dimer interface [polypeptide binding]; other site 360911001670 motif 1; other site 360911001671 active site 360911001672 motif 2; other site 360911001673 motif 3; other site 360911001674 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 360911001675 Recombination protein O N terminal; Region: RecO_N; pfam11967 360911001676 Recombination protein O C terminal; Region: RecO_C; pfam02565 360911001677 GTPase Era; Reviewed; Region: era; PRK00089 360911001678 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 360911001679 G1 box; other site 360911001680 GTP/Mg2+ binding site [chemical binding]; other site 360911001681 Switch I region; other site 360911001682 G2 box; other site 360911001683 Switch II region; other site 360911001684 G3 box; other site 360911001685 G4 box; other site 360911001686 G5 box; other site 360911001687 KH domain; Region: KH_2; pfam07650 360911001688 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 360911001689 metal-binding heat shock protein; Provisional; Region: PRK00016 360911001690 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 360911001691 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 360911001692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911001693 Zn2+ binding site [ion binding]; other site 360911001694 Mg2+ binding site [ion binding]; other site 360911001695 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 360911001696 PhoH-like protein; Region: PhoH; pfam02562 360911001697 hypothetical protein; Provisional; Region: PRK13665 360911001698 Yqey-like protein; Region: YqeY; pfam09424 360911001699 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 360911001700 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 360911001701 intersubunit interface [polypeptide binding]; other site 360911001702 active site 360911001703 catalytic residue [active] 360911001704 Predicted permeases [General function prediction only]; Region: RarD; COG2962 360911001705 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 360911001706 cystathionine beta-lyase; Provisional; Region: PRK07671 360911001707 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 360911001708 homodimer interface [polypeptide binding]; other site 360911001709 substrate-cofactor binding pocket; other site 360911001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001711 catalytic residue [active] 360911001712 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360911001713 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360911001714 dimer interface [polypeptide binding]; other site 360911001715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911001716 catalytic residue [active] 360911001717 S-ribosylhomocysteinase; Provisional; Region: PRK02260 360911001718 Methyltransferase domain; Region: Methyltransf_23; pfam13489 360911001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001720 S-adenosylmethionine binding site [chemical binding]; other site 360911001721 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 360911001722 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 360911001723 putative active site [active] 360911001724 catalytic triad [active] 360911001725 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 360911001726 PA/protease or protease-like domain interface [polypeptide binding]; other site 360911001727 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 360911001728 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 360911001729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 360911001730 RNA methyltransferase, RsmE family; Region: TIGR00046 360911001731 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 360911001732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911001733 S-adenosylmethionine binding site [chemical binding]; other site 360911001734 chaperone protein DnaJ; Provisional; Region: PRK14280 360911001735 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360911001736 HSP70 interaction site [polypeptide binding]; other site 360911001737 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 360911001738 Zn binding sites [ion binding]; other site 360911001739 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 360911001740 dimer interface [polypeptide binding]; other site 360911001741 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 360911001742 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 360911001743 nucleotide binding site [chemical binding]; other site 360911001744 NEF interaction site [polypeptide binding]; other site 360911001745 SBD interface [polypeptide binding]; other site 360911001746 heat shock protein GrpE; Provisional; Region: PRK14140 360911001747 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 360911001748 dimer interface [polypeptide binding]; other site 360911001749 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 360911001750 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 360911001751 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 360911001752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 360911001753 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 360911001754 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 360911001755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911001756 FeS/SAM binding site; other site 360911001757 HemN C-terminal domain; Region: HemN_C; pfam06969 360911001758 Uncharacterized conserved protein [Function unknown]; Region: COG4198 360911001759 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 360911001760 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 360911001761 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 360911001762 putative ligand binding site [chemical binding]; other site 360911001763 putative NAD binding site [chemical binding]; other site 360911001764 putative catalytic site [active] 360911001765 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 360911001766 L-serine binding site [chemical binding]; other site 360911001767 ACT domain interface; other site 360911001768 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 360911001769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911001770 catalytic residue [active] 360911001771 GTP-binding protein LepA; Provisional; Region: PRK05433 360911001772 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 360911001773 G1 box; other site 360911001774 putative GEF interaction site [polypeptide binding]; other site 360911001775 GTP/Mg2+ binding site [chemical binding]; other site 360911001776 Switch I region; other site 360911001777 G2 box; other site 360911001778 G3 box; other site 360911001779 Switch II region; other site 360911001780 G4 box; other site 360911001781 G5 box; other site 360911001782 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 360911001783 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 360911001784 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 360911001785 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 360911001786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 360911001787 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 360911001788 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 360911001789 YqzM-like protein; Region: YqzM; pfam14141 360911001790 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 360911001791 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 360911001792 Competence protein; Region: Competence; pfam03772 360911001793 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 360911001794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 360911001795 SLBB domain; Region: SLBB; pfam10531 360911001796 comEA protein; Region: comE; TIGR01259 360911001797 Helix-hairpin-helix motif; Region: HHH; pfam00633 360911001798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911001799 dimerization interface [polypeptide binding]; other site 360911001800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911001801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911001802 dimer interface [polypeptide binding]; other site 360911001803 putative CheW interface [polypeptide binding]; other site 360911001804 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 360911001805 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 360911001806 ligand binding site [chemical binding]; other site 360911001807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 360911001808 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 360911001809 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 360911001810 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 360911001811 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 360911001812 ribonuclease HIII; Provisional; Region: PRK00996 360911001813 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 360911001814 RNA/DNA hybrid binding site [nucleotide binding]; other site 360911001815 active site 360911001816 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 360911001817 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911001818 nucleophilic elbow; other site 360911001819 catalytic triad; other site 360911001820 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 360911001821 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911001822 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 360911001823 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 360911001824 putative tRNA-binding site [nucleotide binding]; other site 360911001825 B3/4 domain; Region: B3_4; pfam03483 360911001826 tRNA synthetase B5 domain; Region: B5; smart00874 360911001827 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 360911001828 dimer interface [polypeptide binding]; other site 360911001829 motif 1; other site 360911001830 motif 3; other site 360911001831 motif 2; other site 360911001832 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 360911001833 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 360911001834 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 360911001835 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 360911001836 dimer interface [polypeptide binding]; other site 360911001837 motif 1; other site 360911001838 active site 360911001839 motif 2; other site 360911001840 motif 3; other site 360911001841 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 360911001842 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 360911001843 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360911001844 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 360911001845 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 360911001846 oligomer interface [polypeptide binding]; other site 360911001847 active site 360911001848 metal binding site [ion binding]; metal-binding site 360911001849 dUTPase; Region: dUTPase_2; pfam08761 360911001850 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 360911001851 active site 360911001852 homodimer interface [polypeptide binding]; other site 360911001853 metal binding site [ion binding]; metal-binding site 360911001854 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 360911001855 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 360911001856 23S rRNA binding site [nucleotide binding]; other site 360911001857 L21 binding site [polypeptide binding]; other site 360911001858 L13 binding site [polypeptide binding]; other site 360911001859 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 360911001860 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 360911001861 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 360911001862 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 360911001863 Predicted secreted protein [Function unknown]; Region: COG4086 360911001864 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 360911001865 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 360911001866 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 360911001867 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 360911001868 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 360911001869 active site 360911001870 dimer interface [polypeptide binding]; other site 360911001871 motif 1; other site 360911001872 motif 2; other site 360911001873 motif 3; other site 360911001874 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 360911001875 anticodon binding site; other site 360911001876 primosomal protein DnaI; Reviewed; Region: PRK08939 360911001877 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 360911001878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911001879 Walker A motif; other site 360911001880 ATP binding site [chemical binding]; other site 360911001881 Walker B motif; other site 360911001882 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 360911001883 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 360911001884 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 360911001885 ATP cone domain; Region: ATP-cone; pfam03477 360911001886 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 360911001887 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 360911001888 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 360911001889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 360911001890 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 360911001891 active site 360911001892 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 360911001893 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 360911001894 CoA-binding site [chemical binding]; other site 360911001895 ATP-binding [chemical binding]; other site 360911001896 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 360911001897 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 360911001898 DNA binding site [nucleotide binding] 360911001899 catalytic residue [active] 360911001900 H2TH interface [polypeptide binding]; other site 360911001901 putative catalytic residues [active] 360911001902 turnover-facilitating residue; other site 360911001903 intercalation triad [nucleotide binding]; other site 360911001904 8OG recognition residue [nucleotide binding]; other site 360911001905 putative reading head residues; other site 360911001906 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 360911001907 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 360911001908 DNA polymerase I; Provisional; Region: PRK05755 360911001909 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360911001910 active site 360911001911 metal binding site 1 [ion binding]; metal-binding site 360911001912 putative 5' ssDNA interaction site; other site 360911001913 metal binding site 3; metal-binding site 360911001914 metal binding site 2 [ion binding]; metal-binding site 360911001915 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360911001916 putative DNA binding site [nucleotide binding]; other site 360911001917 putative metal binding site [ion binding]; other site 360911001918 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 360911001919 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 360911001920 active site 360911001921 DNA binding site [nucleotide binding] 360911001922 catalytic site [active] 360911001923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911001924 dimerization interface [polypeptide binding]; other site 360911001925 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 360911001926 PAS domain; Region: PAS; smart00091 360911001927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911001928 dimer interface [polypeptide binding]; other site 360911001929 phosphorylation site [posttranslational modification] 360911001930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911001931 ATP binding site [chemical binding]; other site 360911001932 Mg2+ binding site [ion binding]; other site 360911001933 G-X-G motif; other site 360911001934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911001935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911001936 active site 360911001937 phosphorylation site [posttranslational modification] 360911001938 intermolecular recognition site; other site 360911001939 dimerization interface [polypeptide binding]; other site 360911001940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911001941 DNA binding site [nucleotide binding] 360911001942 malate dehydrogenase; Reviewed; Region: PRK06223 360911001943 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 360911001944 NAD(P) binding site [chemical binding]; other site 360911001945 dimer interface [polypeptide binding]; other site 360911001946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911001947 substrate binding site [chemical binding]; other site 360911001948 isocitrate dehydrogenase; Reviewed; Region: PRK07006 360911001949 isocitrate dehydrogenase; Validated; Region: PRK07362 360911001950 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 360911001951 dimer interface [polypeptide binding]; other site 360911001952 Citrate synthase; Region: Citrate_synt; pfam00285 360911001953 active site 360911001954 citrylCoA binding site [chemical binding]; other site 360911001955 oxalacetate/citrate binding site [chemical binding]; other site 360911001956 coenzyme A binding site [chemical binding]; other site 360911001957 catalytic triad [active] 360911001958 Protein of unknown function (DUF441); Region: DUF441; pfam04284 360911001959 pyruvate kinase; Provisional; Region: PRK06354 360911001960 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 360911001961 domain interfaces; other site 360911001962 active site 360911001963 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 360911001964 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 360911001965 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 360911001966 active site 360911001967 ADP/pyrophosphate binding site [chemical binding]; other site 360911001968 dimerization interface [polypeptide binding]; other site 360911001969 allosteric effector site; other site 360911001970 fructose-1,6-bisphosphate binding site; other site 360911001971 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 360911001972 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 360911001973 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 360911001974 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 360911001975 Transcriptional regulators [Transcription]; Region: FadR; COG2186 360911001976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911001977 DNA-binding site [nucleotide binding]; DNA binding site 360911001978 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 360911001979 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 360911001980 active site 360911001981 PHP Thumb interface [polypeptide binding]; other site 360911001982 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 360911001983 generic binding surface I; other site 360911001984 generic binding surface II; other site 360911001985 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 360911001986 DHH family; Region: DHH; pfam01368 360911001987 DHHA1 domain; Region: DHHA1; pfam02272 360911001988 YtpI-like protein; Region: YtpI; pfam14007 360911001989 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 360911001990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911001991 DNA-binding site [nucleotide binding]; DNA binding site 360911001992 DRTGG domain; Region: DRTGG; pfam07085 360911001993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 360911001994 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 360911001995 active site 2 [active] 360911001996 active site 1 [active] 360911001997 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 360911001998 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360911001999 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 360911002000 active site 360911002001 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 360911002002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911002003 active site 360911002004 metal binding site [ion binding]; metal-binding site 360911002005 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 360911002006 classical (c) SDRs; Region: SDR_c; cd05233 360911002007 NAD(P) binding site [chemical binding]; other site 360911002008 active site 360911002009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360911002010 Ligand Binding Site [chemical binding]; other site 360911002011 Bacterial SH3 domain; Region: SH3_3; cl17532 360911002012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 360911002013 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 360911002014 propionate/acetate kinase; Provisional; Region: PRK12379 360911002015 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 360911002016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911002017 S-adenosylmethionine binding site [chemical binding]; other site 360911002018 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 360911002019 dimer interface [polypeptide binding]; other site 360911002020 catalytic triad [active] 360911002021 peroxidatic and resolving cysteines [active] 360911002022 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 360911002023 ATP-NAD kinase; Region: NAD_kinase; pfam01513 360911002024 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 360911002025 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 360911002026 active site 360911002027 septation ring formation regulator EzrA; Provisional; Region: PRK04778 360911002028 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 360911002029 GAF domain; Region: GAF_2; pfam13185 360911002030 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 360911002031 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 360911002032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911002033 RNA binding surface [nucleotide binding]; other site 360911002034 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911002035 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 360911002036 synthetase active site [active] 360911002037 NTP binding site [chemical binding]; other site 360911002038 metal binding site [ion binding]; metal-binding site 360911002039 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 360911002040 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 360911002041 active site 360911002042 HIGH motif; other site 360911002043 dimer interface [polypeptide binding]; other site 360911002044 KMSKS motif; other site 360911002045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911002046 RNA binding surface [nucleotide binding]; other site 360911002047 Transglycosylase; Region: Transgly; pfam00912 360911002048 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 360911002049 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 360911002050 acetyl-CoA synthetase; Provisional; Region: PRK04319 360911002051 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 360911002052 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 360911002053 active site 360911002054 acyl-activating enzyme (AAE) consensus motif; other site 360911002055 putative CoA binding site [chemical binding]; other site 360911002056 AMP binding site [chemical binding]; other site 360911002057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911002058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002059 Coenzyme A binding pocket [chemical binding]; other site 360911002060 FOG: CBS domain [General function prediction only]; Region: COG0517 360911002061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 360911002062 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 360911002063 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 360911002064 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 360911002065 active site 360911002066 Zn binding site [ion binding]; other site 360911002067 catabolite control protein A; Region: ccpA; TIGR01481 360911002068 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911002069 DNA binding site [nucleotide binding] 360911002070 domain linker motif; other site 360911002071 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 360911002072 dimerization interface [polypeptide binding]; other site 360911002073 effector binding site; other site 360911002074 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 360911002075 Chorismate mutase type II; Region: CM_2; cl00693 360911002076 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 360911002077 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 360911002078 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 360911002079 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 360911002080 Ferritin-like domain; Region: Ferritin; pfam00210 360911002081 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 360911002082 dimerization interface [polypeptide binding]; other site 360911002083 DPS ferroxidase diiron center [ion binding]; other site 360911002084 ion pore; other site 360911002085 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 360911002086 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911002087 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911002088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911002089 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 360911002090 putative tRNA-binding site [nucleotide binding]; other site 360911002091 hypothetical protein; Provisional; Region: PRK13668 360911002092 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911002093 catalytic residues [active] 360911002094 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 360911002095 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 360911002096 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911002097 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 360911002098 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 360911002099 oligomer interface [polypeptide binding]; other site 360911002100 active site 360911002101 metal binding site [ion binding]; metal-binding site 360911002102 Predicted small secreted protein [Function unknown]; Region: COG5584 360911002103 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 360911002104 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 360911002105 DAK2 domain; Region: Dak2; cl03685 360911002106 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 360911002107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911002108 S-adenosylmethionine binding site [chemical binding]; other site 360911002109 Phosphotransferase enzyme family; Region: APH; pfam01636 360911002110 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 360911002111 active site 360911002112 substrate binding site [chemical binding]; other site 360911002113 ATP binding site [chemical binding]; other site 360911002114 pullulanase, type I; Region: pulA_typeI; TIGR02104 360911002115 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 360911002116 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 360911002117 Ca binding site [ion binding]; other site 360911002118 active site 360911002119 catalytic site [active] 360911002120 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 360911002121 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 360911002122 sugar efflux transporter; Region: 2A0120; TIGR00899 360911002123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002124 putative substrate translocation pore; other site 360911002125 dipeptidase PepV; Reviewed; Region: PRK07318 360911002126 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 360911002127 active site 360911002128 metal binding site [ion binding]; metal-binding site 360911002129 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 360911002130 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 360911002131 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 360911002132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911002133 RNA binding surface [nucleotide binding]; other site 360911002134 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 360911002135 active site 360911002136 uracil binding [chemical binding]; other site 360911002137 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360911002138 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 360911002139 HI0933-like protein; Region: HI0933_like; pfam03486 360911002140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911002141 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 360911002142 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 360911002143 metal binding site [ion binding]; metal-binding site 360911002144 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 360911002145 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 360911002146 HIGH motif; other site 360911002147 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360911002148 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911002149 active site 360911002150 KMSKS motif; other site 360911002151 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 360911002152 tRNA binding surface [nucleotide binding]; other site 360911002153 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 360911002154 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 360911002155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911002157 putative substrate translocation pore; other site 360911002158 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 360911002159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 360911002160 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 360911002161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911002162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911002163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 360911002165 Coenzyme A binding pocket [chemical binding]; other site 360911002166 S-adenosylmethionine synthetase; Validated; Region: PRK05250 360911002167 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 360911002168 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 360911002169 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 360911002170 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 360911002171 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 360911002172 active site 360911002173 substrate-binding site [chemical binding]; other site 360911002174 metal-binding site [ion binding] 360911002175 ATP binding site [chemical binding]; other site 360911002176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911002177 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360911002178 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 360911002179 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 360911002180 nudix motif; other site 360911002181 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 360911002182 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 360911002183 active site 360911002184 dimer interface [polypeptide binding]; other site 360911002185 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 360911002186 dimer interface [polypeptide binding]; other site 360911002187 active site 360911002188 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 360911002189 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 360911002190 dimer interface [polypeptide binding]; other site 360911002191 active site 360911002192 metal binding site [ion binding]; metal-binding site 360911002193 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911002194 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360911002195 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 360911002196 general stress protein 13; Validated; Region: PRK08059 360911002197 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 360911002198 RNA binding site [nucleotide binding]; other site 360911002199 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 360911002200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911002201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911002202 hypothetical protein; Validated; Region: PRK07682 360911002203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911002204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911002205 homodimer interface [polypeptide binding]; other site 360911002206 catalytic residue [active] 360911002207 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 360911002208 AsnC family; Region: AsnC_trans_reg; pfam01037 360911002209 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911002210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911002211 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 360911002212 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 360911002213 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 360911002214 Class I ribonucleotide reductase; Region: RNR_I; cd01679 360911002215 active site 360911002216 dimer interface [polypeptide binding]; other site 360911002217 catalytic residues [active] 360911002218 effector binding site; other site 360911002219 R2 peptide binding site; other site 360911002220 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 360911002221 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 360911002222 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 360911002223 dimer interface [polypeptide binding]; other site 360911002224 putative radical transfer pathway; other site 360911002225 diiron center [ion binding]; other site 360911002226 tyrosyl radical; other site 360911002227 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911002228 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911002229 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911002230 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 360911002231 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 360911002232 active site 360911002233 metal binding site [ion binding]; metal-binding site 360911002234 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 360911002235 homodimer interface [polypeptide binding]; other site 360911002236 metal binding site [ion binding]; metal-binding site 360911002237 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 360911002238 metal binding site [ion binding]; metal-binding site 360911002239 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 360911002240 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911002241 Protein of unknown function (DUF429); Region: DUF429; cl12046 360911002242 multifunctional aminopeptidase A; Provisional; Region: PRK00913 360911002243 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 360911002244 interface (dimer of trimers) [polypeptide binding]; other site 360911002245 Substrate-binding/catalytic site; other site 360911002246 Zn-binding sites [ion binding]; other site 360911002247 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 360911002248 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 360911002249 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 360911002250 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 360911002251 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911002252 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911002253 active site 360911002254 catalytic tetrad [active] 360911002255 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 360911002256 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911002257 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911002258 active site turn [active] 360911002259 phosphorylation site [posttranslational modification] 360911002260 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911002261 HPr interaction site; other site 360911002262 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911002263 active site 360911002264 phosphorylation site [posttranslational modification] 360911002265 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911002266 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 360911002267 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911002268 active site turn [active] 360911002269 phosphorylation site [posttranslational modification] 360911002270 CAT RNA binding domain; Region: CAT_RBD; smart01061 360911002271 transcriptional antiterminator BglG; Provisional; Region: PRK09772 360911002272 PRD domain; Region: PRD; pfam00874 360911002273 PRD domain; Region: PRD; pfam00874 360911002274 Putative membrane protein; Region: YuiB; pfam14068 360911002275 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 360911002276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002277 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 360911002278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911002279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002281 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360911002282 NAD(P) binding site [chemical binding]; other site 360911002283 active site 360911002284 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 360911002285 Predicted membrane protein [Function unknown]; Region: COG3601 360911002286 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 360911002287 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 360911002288 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 360911002289 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 360911002290 Nucleoside recognition; Region: Gate; pfam07670 360911002291 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 360911002292 hypothetical protein; Provisional; Region: PRK13669 360911002293 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 360911002294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002295 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 360911002296 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 360911002297 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 360911002298 active site 360911002299 catalytic residues [active] 360911002300 MG2 domain; Region: A2M_N; pfam01835 360911002301 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 360911002302 heme-binding site [chemical binding]; other site 360911002303 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911002304 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911002305 dimer interface [polypeptide binding]; other site 360911002306 putative CheW interface [polypeptide binding]; other site 360911002307 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 360911002308 NifU-like domain; Region: NifU; pfam01106 360911002309 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 360911002310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002311 active site 360911002312 motif I; other site 360911002313 motif II; other site 360911002314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002315 Uncharacterized conserved protein [Function unknown]; Region: COG2445 360911002316 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 360911002317 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 360911002318 putative active site [active] 360911002319 Protein of unknown function (DUF975); Region: DUF975; pfam06161 360911002320 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 360911002321 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 360911002322 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 360911002323 active site 360911002324 metal binding site [ion binding]; metal-binding site 360911002325 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360911002326 Protein of unknown function DUF72; Region: DUF72; pfam01904 360911002327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911002329 putative substrate translocation pore; other site 360911002330 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 360911002331 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 360911002332 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911002333 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911002334 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 360911002335 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 360911002336 NAD binding site [chemical binding]; other site 360911002337 dimer interface [polypeptide binding]; other site 360911002338 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911002339 substrate binding site [chemical binding]; other site 360911002340 YCII-related domain; Region: YCII; cl00999 360911002341 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 360911002342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911002343 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 360911002344 DNA binding residues [nucleotide binding] 360911002345 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 360911002346 FeS assembly protein SufB; Region: sufB; TIGR01980 360911002347 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 360911002348 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 360911002349 trimerization site [polypeptide binding]; other site 360911002350 active site 360911002351 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 360911002352 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 360911002353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911002354 catalytic residue [active] 360911002355 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 360911002356 FeS assembly protein SufD; Region: sufD; TIGR01981 360911002357 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 360911002358 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 360911002359 Walker A/P-loop; other site 360911002360 ATP binding site [chemical binding]; other site 360911002361 Q-loop/lid; other site 360911002362 ABC transporter signature motif; other site 360911002363 Walker B; other site 360911002364 D-loop; other site 360911002365 H-loop/switch region; other site 360911002366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911002368 putative substrate translocation pore; other site 360911002369 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 360911002370 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 360911002371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911002372 dimer interface [polypeptide binding]; other site 360911002373 conserved gate region; other site 360911002374 ABC-ATPase subunit interface; other site 360911002375 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 360911002376 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 360911002377 Walker A/P-loop; other site 360911002378 ATP binding site [chemical binding]; other site 360911002379 Q-loop/lid; other site 360911002380 ABC transporter signature motif; other site 360911002381 Walker B; other site 360911002382 D-loop; other site 360911002383 H-loop/switch region; other site 360911002384 NIL domain; Region: NIL; pfam09383 360911002385 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911002386 catalytic residues [active] 360911002387 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 360911002388 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 360911002389 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 360911002390 lipoyl attachment site [posttranslational modification]; other site 360911002391 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 360911002392 ArsC family; Region: ArsC; pfam03960 360911002393 putative ArsC-like catalytic residues; other site 360911002394 putative TRX-like catalytic residues [active] 360911002395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 360911002396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 360911002397 active site 360911002398 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 360911002399 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 360911002400 dimer interface [polypeptide binding]; other site 360911002401 active site 360911002402 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 360911002403 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 360911002404 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360911002405 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360911002406 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 360911002407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360911002408 substrate binding site [chemical binding]; other site 360911002409 oxyanion hole (OAH) forming residues; other site 360911002410 short chain dehydrogenase; Provisional; Region: PRK06701 360911002411 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 360911002412 NAD binding site [chemical binding]; other site 360911002413 metal binding site [ion binding]; metal-binding site 360911002414 active site 360911002415 YcxB-like protein; Region: YcxB; pfam14317 360911002416 YcxB-like protein; Region: YcxB; pfam14317 360911002417 Proline dehydrogenase; Region: Pro_dh; cl03282 360911002418 Haemolysin-III related; Region: HlyIII; cl03831 360911002419 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 360911002420 Carbon starvation protein CstA; Region: CstA; pfam02554 360911002421 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 360911002422 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 360911002423 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 360911002424 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 360911002425 active site 360911002426 metal binding site [ion binding]; metal-binding site 360911002427 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360911002428 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 360911002429 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 360911002430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 360911002431 nucleotide binding region [chemical binding]; other site 360911002432 ATP-binding site [chemical binding]; other site 360911002433 DNA polymerase IV; Reviewed; Region: PRK03103 360911002434 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 360911002435 active site 360911002436 DNA binding site [nucleotide binding] 360911002437 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 360911002438 YolD-like protein; Region: YolD; pfam08863 360911002439 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 360911002440 putative transporter; Provisional; Region: PRK11660 360911002441 Sulfate transporter family; Region: Sulfate_transp; pfam00916 360911002442 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 360911002443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911002444 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 360911002445 Walker A/P-loop; other site 360911002446 ATP binding site [chemical binding]; other site 360911002447 Q-loop/lid; other site 360911002448 ABC transporter signature motif; other site 360911002449 Walker B; other site 360911002450 D-loop; other site 360911002451 H-loop/switch region; other site 360911002452 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911002453 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 360911002454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360911002455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911002456 NAD(P) binding site [chemical binding]; other site 360911002457 active site 360911002458 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 360911002459 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 360911002460 active site 360911002461 NTP binding site [chemical binding]; other site 360911002462 nucleic acid binding site [nucleotide binding]; other site 360911002463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360911002464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911002465 salt bridge; other site 360911002466 non-specific DNA binding site [nucleotide binding]; other site 360911002467 sequence-specific DNA binding site [nucleotide binding]; other site 360911002468 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911002469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002470 Coenzyme A binding pocket [chemical binding]; other site 360911002471 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360911002472 active site 360911002473 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 360911002474 SmpB-tmRNA interface; other site 360911002475 ribonuclease R; Region: RNase_R; TIGR02063 360911002476 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 360911002477 RNB domain; Region: RNB; pfam00773 360911002478 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 360911002479 RNA binding site [nucleotide binding]; other site 360911002480 Esterase/lipase [General function prediction only]; Region: COG1647 360911002481 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360911002482 Preprotein translocase SecG subunit; Region: SecG; cl09123 360911002483 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002484 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002485 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002486 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911002487 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911002488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911002489 putative glycosyl transferase; Provisional; Region: PRK10307 360911002490 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 360911002491 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 360911002492 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 360911002493 active site 360911002494 tetramer interface; other site 360911002495 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 360911002496 active site 360911002497 ATP binding site [chemical binding]; other site 360911002498 Phosphotransferase enzyme family; Region: APH; pfam01636 360911002499 enolase; Provisional; Region: eno; PRK00077 360911002500 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 360911002501 dimer interface [polypeptide binding]; other site 360911002502 metal binding site [ion binding]; metal-binding site 360911002503 substrate binding pocket [chemical binding]; other site 360911002504 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 360911002505 phosphoglyceromutase; Provisional; Region: PRK05434 360911002506 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 360911002507 triosephosphate isomerase; Provisional; Region: PRK14565 360911002508 substrate binding site [chemical binding]; other site 360911002509 dimer interface [polypeptide binding]; other site 360911002510 catalytic triad [active] 360911002511 Phosphoglycerate kinase; Region: PGK; pfam00162 360911002512 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 360911002513 substrate binding site [chemical binding]; other site 360911002514 hinge regions; other site 360911002515 ADP binding site [chemical binding]; other site 360911002516 catalytic site [active] 360911002517 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 360911002518 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 360911002519 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 360911002520 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 360911002521 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360911002522 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 360911002523 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 360911002524 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 360911002525 Clp protease; Region: CLP_protease; pfam00574 360911002526 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 360911002527 oligomer interface [polypeptide binding]; other site 360911002528 active site residues [active] 360911002529 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 360911002530 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 360911002531 DNA binding residues [nucleotide binding] 360911002532 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 360911002533 hypothetical protein; Provisional; Region: PRK04164 360911002534 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911002535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 360911002536 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 360911002537 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 360911002538 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 360911002539 phosphate binding site [ion binding]; other site 360911002540 putative substrate binding pocket [chemical binding]; other site 360911002541 dimer interface [polypeptide binding]; other site 360911002542 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 360911002543 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 360911002544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911002545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360911002547 binding surface 360911002548 TPR motif; other site 360911002549 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 360911002550 putative trimer interface [polypeptide binding]; other site 360911002551 putative CoA binding site [chemical binding]; other site 360911002552 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 360911002553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002554 motif II; other site 360911002555 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 360911002556 HPr kinase/phosphorylase; Provisional; Region: PRK05428 360911002557 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 360911002558 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 360911002559 Hpr binding site; other site 360911002560 active site 360911002561 homohexamer subunit interaction site [polypeptide binding]; other site 360911002562 Uncharacterized conserved protein [Function unknown]; Region: COG3595 360911002563 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911002564 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 360911002565 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 360911002566 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 360911002567 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 360911002568 excinuclease ABC subunit B; Provisional; Region: PRK05298 360911002569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911002570 ATP binding site [chemical binding]; other site 360911002571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002572 nucleotide binding region [chemical binding]; other site 360911002573 ATP-binding site [chemical binding]; other site 360911002574 Ultra-violet resistance protein B; Region: UvrB; pfam12344 360911002575 UvrB/uvrC motif; Region: UVR; pfam02151 360911002576 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 360911002577 amphipathic channel; other site 360911002578 Asn-Pro-Ala signature motifs; other site 360911002579 glycerol kinase; Provisional; Region: glpK; PRK00047 360911002580 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 360911002581 N- and C-terminal domain interface [polypeptide binding]; other site 360911002582 active site 360911002583 MgATP binding site [chemical binding]; other site 360911002584 catalytic site [active] 360911002585 metal binding site [ion binding]; metal-binding site 360911002586 glycerol binding site [chemical binding]; other site 360911002587 homotetramer interface [polypeptide binding]; other site 360911002588 homodimer interface [polypeptide binding]; other site 360911002589 FBP binding site [chemical binding]; other site 360911002590 protein IIAGlc interface [polypeptide binding]; other site 360911002591 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 360911002592 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911002593 protein binding site [polypeptide binding]; other site 360911002594 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 360911002595 C-terminal peptidase (prc); Region: prc; TIGR00225 360911002596 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 360911002597 protein binding site [polypeptide binding]; other site 360911002598 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 360911002599 Catalytic dyad [active] 360911002600 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 360911002601 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 360911002602 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 360911002603 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911002604 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 360911002605 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 360911002606 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 360911002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911002608 Walker A/P-loop; other site 360911002609 ATP binding site [chemical binding]; other site 360911002610 Q-loop/lid; other site 360911002611 ABC transporter signature motif; other site 360911002612 Walker B; other site 360911002613 D-loop; other site 360911002614 H-loop/switch region; other site 360911002615 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 360911002616 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 360911002617 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002618 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002619 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002620 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911002621 peptide chain release factor 2; Validated; Region: prfB; PRK00578 360911002622 PCRF domain; Region: PCRF; pfam03462 360911002623 RF-1 domain; Region: RF-1; pfam00472 360911002624 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 360911002625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 360911002626 ATP binding site [chemical binding]; other site 360911002627 putative Mg++ binding site [ion binding]; other site 360911002628 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 360911002629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002630 nucleotide binding region [chemical binding]; other site 360911002631 ATP-binding site [chemical binding]; other site 360911002632 SEC-C motif; Region: SEC-C; pfam02810 360911002633 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 360911002634 30S subunit binding site; other site 360911002635 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360911002636 DNA-binding site [nucleotide binding]; DNA binding site 360911002637 RNA-binding motif; other site 360911002638 ComK protein; Region: ComK; pfam06338 360911002639 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 360911002640 Flagellar protein FliS; Region: FliS; cl00654 360911002641 flagellin; Provisional; Region: PRK12804 360911002642 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360911002643 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360911002644 Protein of unknown function (DUF327); Region: DUF327; pfam03885 360911002645 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 360911002646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 360911002647 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 360911002648 DinB superfamily; Region: DinB_2; pfam12867 360911002649 Protein of unknown function (DUF402); Region: DUF402; cl00979 360911002650 Bacterial SH3 domain; Region: SH3_3; cl17532 360911002651 Bacterial SH3 domain; Region: SH3_3; cl17532 360911002652 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 360911002653 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 360911002654 Flagellar protein FliT; Region: FliT; pfam05400 360911002655 flagellar protein FliS; Validated; Region: fliS; PRK05685 360911002656 flagellar capping protein; Validated; Region: fliD; PRK07737 360911002657 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 360911002658 Protein of unknown function (DUF690); Region: DUF690; cl04939 360911002659 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 360911002660 FlaG protein; Region: FlaG; cl00591 360911002661 flagellin; Provisional; Region: PRK12804 360911002662 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360911002663 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360911002664 HAMP domain; Region: HAMP; pfam00672 360911002665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911002666 dimer interface [polypeptide binding]; other site 360911002667 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 360911002668 putative CheW interface [polypeptide binding]; other site 360911002669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002670 Coenzyme A binding pocket [chemical binding]; other site 360911002671 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911002672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002673 Coenzyme A binding pocket [chemical binding]; other site 360911002674 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 360911002675 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 360911002676 Uncharacterized conserved protein [Function unknown]; Region: COG1359 360911002677 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002678 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002679 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002680 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911002681 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911002682 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002683 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911002684 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911002685 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 360911002686 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 360911002687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911002688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002689 metal binding site [ion binding]; metal-binding site 360911002690 active site 360911002691 I-site; other site 360911002692 carbon storage regulator; Provisional; Region: PRK01712 360911002693 flagellar assembly protein FliW; Provisional; Region: PRK13285 360911002694 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 360911002695 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360911002696 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360911002697 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 360911002698 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360911002699 FlgN protein; Region: FlgN; pfam05130 360911002700 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 360911002701 flagellar operon protein TIGR03826; Region: YvyF 360911002702 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 360911002703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911002704 active site 360911002705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911002706 ATP binding site [chemical binding]; other site 360911002707 putative Mg++ binding site [ion binding]; other site 360911002708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911002709 nucleotide binding region [chemical binding]; other site 360911002710 ATP-binding site [chemical binding]; other site 360911002711 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911002712 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911002713 Ca binding site [ion binding]; other site 360911002714 active site 360911002715 catalytic site [active] 360911002716 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 360911002717 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 360911002718 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911002719 active site turn [active] 360911002720 phosphorylation site [posttranslational modification] 360911002721 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911002722 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 360911002723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911002724 DNA-binding site [nucleotide binding]; DNA binding site 360911002725 UTRA domain; Region: UTRA; pfam07702 360911002726 EDD domain protein, DegV family; Region: DegV; TIGR00762 360911002727 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 360911002728 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360911002729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911002730 active site 360911002731 phosphorylation site [posttranslational modification] 360911002732 intermolecular recognition site; other site 360911002733 dimerization interface [polypeptide binding]; other site 360911002734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360911002735 DNA binding residues [nucleotide binding] 360911002736 dimerization interface [polypeptide binding]; other site 360911002737 Sensor protein DegS; Region: DegS; pfam05384 360911002738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 360911002739 Histidine kinase; Region: HisKA_3; pfam07730 360911002740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911002741 ATP binding site [chemical binding]; other site 360911002742 Mg2+ binding site [ion binding]; other site 360911002743 G-X-G motif; other site 360911002744 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 360911002745 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 360911002746 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 360911002747 Transcriptional regulator [Transcription]; Region: LytR; COG1316 360911002748 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 360911002749 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 360911002750 Mg++ binding site [ion binding]; other site 360911002751 putative catalytic motif [active] 360911002752 substrate binding site [chemical binding]; other site 360911002753 beta-phosphoglucomutase; Region: bPGM; TIGR01990 360911002754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911002755 motif II; other site 360911002756 Asp23 family; Region: Asp23; pfam03780 360911002757 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 360911002758 Predicted esterase [General function prediction only]; Region: COG0400 360911002759 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 360911002760 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 360911002761 Walker A/P-loop; other site 360911002762 ATP binding site [chemical binding]; other site 360911002763 Q-loop/lid; other site 360911002764 ABC transporter signature motif; other site 360911002765 Walker B; other site 360911002766 D-loop; other site 360911002767 H-loop/switch region; other site 360911002768 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 360911002769 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 360911002770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911002771 non-specific DNA binding site [nucleotide binding]; other site 360911002772 salt bridge; other site 360911002773 sequence-specific DNA binding site [nucleotide binding]; other site 360911002774 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911002775 HPr interaction site; other site 360911002776 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911002777 active site 360911002778 phosphorylation site [posttranslational modification] 360911002779 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 360911002780 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 360911002781 active site 360911002782 Zn binding site [ion binding]; other site 360911002783 Domain of unknown function (DUF389); Region: DUF389; pfam04087 360911002784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911002785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911002786 active site 360911002787 catalytic tetrad [active] 360911002788 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 360911002789 Predicted transcriptional regulators [Transcription]; Region: COG1733 360911002790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911002791 dimerization interface [polypeptide binding]; other site 360911002792 putative DNA binding site [nucleotide binding]; other site 360911002793 putative Zn2+ binding site [ion binding]; other site 360911002794 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 360911002795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911002796 putative substrate translocation pore; other site 360911002797 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 360911002798 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 360911002799 FOG: CBS domain [General function prediction only]; Region: COG0517 360911002800 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 360911002801 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 360911002802 Secretory lipase; Region: LIP; pfam03583 360911002803 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 360911002804 active site 360911002805 Zn binding site [ion binding]; other site 360911002806 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 360911002807 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 360911002808 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 360911002809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911002810 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 360911002811 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911002812 Transcriptional regulator PadR-like family; Region: PadR; cl17335 360911002813 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 360911002814 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 360911002815 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360911002816 FMN binding site [chemical binding]; other site 360911002817 active site 360911002818 catalytic residues [active] 360911002819 substrate binding site [chemical binding]; other site 360911002820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911002821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911002822 AAA domain; Region: AAA_18; pfam13238 360911002823 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 360911002824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 360911002825 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 360911002826 RibD C-terminal domain; Region: RibD_C; cl17279 360911002827 Uncharacterized conserved protein [Function unknown]; Region: COG1479 360911002828 Protein of unknown function DUF262; Region: DUF262; pfam03235 360911002829 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 360911002830 Uncharacterized conserved protein [Function unknown]; Region: COG1479 360911002831 Protein of unknown function DUF262; Region: DUF262; pfam03235 360911002832 TRAM domain; Region: TRAM; pfam01938 360911002833 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 360911002834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911002835 S-adenosylmethionine binding site [chemical binding]; other site 360911002836 putative lipid kinase; Reviewed; Region: PRK13337 360911002837 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 360911002838 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 360911002839 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 360911002840 GatB domain; Region: GatB_Yqey; smart00845 360911002841 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 360911002842 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 360911002843 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 360911002844 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911002845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911002846 dimerization interface [polypeptide binding]; other site 360911002847 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911002848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911002849 dimer interface [polypeptide binding]; other site 360911002850 putative CheW interface [polypeptide binding]; other site 360911002851 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911002852 amino acid carrier protein; Region: agcS; TIGR00835 360911002853 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 360911002854 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 360911002855 catalytic triad [active] 360911002856 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 360911002857 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 360911002858 Glutamate binding site [chemical binding]; other site 360911002859 homodimer interface [polypeptide binding]; other site 360911002860 NAD binding site [chemical binding]; other site 360911002861 catalytic residues [active] 360911002862 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 360911002863 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 360911002864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911002865 Zn2+ binding site [ion binding]; other site 360911002866 Mg2+ binding site [ion binding]; other site 360911002867 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 360911002868 homopentamer interface [polypeptide binding]; other site 360911002869 active site 360911002870 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 360911002871 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 360911002872 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 360911002873 dimerization interface [polypeptide binding]; other site 360911002874 active site 360911002875 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 360911002876 Lumazine binding domain; Region: Lum_binding; pfam00677 360911002877 Lumazine binding domain; Region: Lum_binding; pfam00677 360911002878 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 360911002879 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 360911002880 catalytic motif [active] 360911002881 Zn binding site [ion binding]; other site 360911002882 RibD C-terminal domain; Region: RibD_C; cl17279 360911002883 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 360911002884 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911002885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002886 metal binding site [ion binding]; metal-binding site 360911002887 active site 360911002888 I-site; other site 360911002889 EDD domain protein, DegV family; Region: DegV; TIGR00762 360911002890 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 360911002891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911002892 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360911002893 Walker A/P-loop; other site 360911002894 ATP binding site [chemical binding]; other site 360911002895 Q-loop/lid; other site 360911002896 ABC transporter signature motif; other site 360911002897 Walker B; other site 360911002898 D-loop; other site 360911002899 H-loop/switch region; other site 360911002900 FtsX-like permease family; Region: FtsX; pfam02687 360911002901 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 360911002902 FtsX-like permease family; Region: FtsX; pfam02687 360911002903 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 360911002904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911002905 Coenzyme A binding pocket [chemical binding]; other site 360911002906 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 360911002907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911002908 catalytic residues [active] 360911002909 EDD domain protein, DegV family; Region: DegV; TIGR00762 360911002910 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 360911002911 RDD family; Region: RDD; pfam06271 360911002912 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 360911002913 active site 360911002914 dimer interface [polypeptide binding]; other site 360911002915 PAS fold; Region: PAS_4; pfam08448 360911002916 PAS fold; Region: PAS_3; pfam08447 360911002917 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911002918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002919 metal binding site [ion binding]; metal-binding site 360911002920 active site 360911002921 I-site; other site 360911002922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911002923 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 360911002924 carbohydrate binding site [chemical binding]; other site 360911002925 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 360911002926 carbohydrate binding site [chemical binding]; other site 360911002927 pullulanase, type I; Region: pulA_typeI; TIGR02104 360911002928 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 360911002929 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 360911002930 Ca binding site [ion binding]; other site 360911002931 active site 360911002932 catalytic site [active] 360911002933 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 360911002934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911002935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911002936 metal binding site [ion binding]; metal-binding site 360911002937 active site 360911002938 I-site; other site 360911002939 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 360911002940 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911002941 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911002942 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 360911002943 active site residue [active] 360911002944 arsenical pump membrane protein; Provisional; Region: PRK15445 360911002945 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 360911002946 transmembrane helices; other site 360911002947 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 360911002948 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 360911002949 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 360911002950 P loop; other site 360911002951 Nucleotide binding site [chemical binding]; other site 360911002952 DTAP/Switch II; other site 360911002953 Switch I; other site 360911002954 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 360911002955 DTAP/Switch II; other site 360911002956 Switch I; other site 360911002957 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 360911002958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911002959 dimerization interface [polypeptide binding]; other site 360911002960 putative DNA binding site [nucleotide binding]; other site 360911002961 putative Zn2+ binding site [ion binding]; other site 360911002962 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 360911002963 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 360911002964 Sulfate transporter family; Region: Sulfate_transp; pfam00916 360911002965 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 360911002966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360911002967 Ligand Binding Site [chemical binding]; other site 360911002968 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911002969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911002970 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911002971 Walker A/P-loop; other site 360911002972 ATP binding site [chemical binding]; other site 360911002973 Q-loop/lid; other site 360911002974 ABC transporter signature motif; other site 360911002975 Walker B; other site 360911002976 D-loop; other site 360911002977 H-loop/switch region; other site 360911002978 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 360911002979 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 360911002980 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 360911002981 putative active site [active] 360911002982 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 360911002983 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 360911002984 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 360911002985 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911002986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911002987 Walker A/P-loop; other site 360911002988 ATP binding site [chemical binding]; other site 360911002989 Q-loop/lid; other site 360911002990 ABC transporter signature motif; other site 360911002991 Walker B; other site 360911002992 D-loop; other site 360911002993 H-loop/switch region; other site 360911002994 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 360911002995 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 360911002996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 360911002997 PAS domain; Region: PAS_9; pfam13426 360911002998 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 360911002999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911003000 putative active site [active] 360911003001 heme pocket [chemical binding]; other site 360911003002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911003003 putative active site [active] 360911003004 heme pocket [chemical binding]; other site 360911003005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003006 metal binding site [ion binding]; metal-binding site 360911003007 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 360911003008 active site 360911003009 I-site; other site 360911003010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911003011 Zn2+ binding site [ion binding]; other site 360911003012 Mg2+ binding site [ion binding]; other site 360911003013 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 360911003014 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911003015 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 360911003016 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 360911003017 Chromate transporter; Region: Chromate_transp; pfam02417 360911003018 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 360911003019 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 360911003020 putative substrate binding site [chemical binding]; other site 360911003021 putative ATP binding site [chemical binding]; other site 360911003022 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 360911003023 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 360911003024 intersubunit interface [polypeptide binding]; other site 360911003025 active site 360911003026 zinc binding site [ion binding]; other site 360911003027 Na+ binding site [ion binding]; other site 360911003028 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 360911003029 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 360911003030 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360911003031 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 360911003032 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360911003033 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 360911003034 beta-galactosidase; Region: BGL; TIGR03356 360911003035 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911003036 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 360911003037 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 360911003038 active site 360911003039 P-loop; other site 360911003040 phosphorylation site [posttranslational modification] 360911003041 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 360911003042 active site 360911003043 methionine cluster; other site 360911003044 phosphorylation site [posttranslational modification] 360911003045 metal binding site [ion binding]; metal-binding site 360911003046 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 360911003047 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 360911003048 catalytic triad [active] 360911003049 catalytic triad [active] 360911003050 oxyanion hole [active] 360911003051 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 360911003052 putative active site [active] 360911003053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003054 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911003055 DHHW protein; Region: DHHW; pfam14286 360911003056 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 360911003057 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 360911003058 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 360911003059 active site 360911003060 homodimer interface [polypeptide binding]; other site 360911003061 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 360911003062 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 360911003063 Walker A/P-loop; other site 360911003064 ATP binding site [chemical binding]; other site 360911003065 Q-loop/lid; other site 360911003066 ABC transporter signature motif; other site 360911003067 Walker B; other site 360911003068 D-loop; other site 360911003069 H-loop/switch region; other site 360911003070 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 360911003071 ABC-2 type transporter; Region: ABC2_membrane; cl17235 360911003072 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 360911003073 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360911003074 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 360911003075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003076 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 360911003077 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911003078 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 360911003080 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 360911003081 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911003082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 360911003083 active site 360911003084 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 360911003085 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360911003086 active site 360911003087 metal binding site [ion binding]; metal-binding site 360911003088 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360911003089 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 360911003090 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 360911003091 Bacterial SH3 domain; Region: SH3_3; cl17532 360911003092 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003093 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003094 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 360911003095 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 360911003096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911003097 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 360911003098 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911003099 active site 360911003100 DNA binding site [nucleotide binding] 360911003101 Int/Topo IB signature motif; other site 360911003102 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 360911003103 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 360911003104 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 360911003105 Collagen binding domain; Region: Collagen_bind; pfam05737 360911003106 Collagen binding domain; Region: Collagen_bind; pfam05737 360911003107 Collagen binding domain; Region: Collagen_bind; pfam05737 360911003108 Collagen binding domain; Region: Collagen_bind; pfam05737 360911003109 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003110 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003111 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003112 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 360911003113 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003114 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003115 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003116 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003117 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003118 Cna protein B-type domain; Region: Cna_B; pfam05738 360911003119 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 360911003120 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 360911003121 Family of unknown function (DUF648); Region: DUF648; pfam04890 360911003122 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 360911003123 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 360911003124 Domain of unknown function DUF87; Region: DUF87; pfam01935 360911003125 AAA-like domain; Region: AAA_10; pfam12846 360911003126 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 360911003127 Dynamin family; Region: Dynamin_N; pfam00350 360911003128 G1 box; other site 360911003129 GTP/Mg2+ binding site [chemical binding]; other site 360911003130 G2 box; other site 360911003131 Switch I region; other site 360911003132 G3 box; other site 360911003133 Switch II region; other site 360911003134 G4 box; other site 360911003135 G5 box; other site 360911003136 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 360911003137 Dynamin family; Region: Dynamin_N; pfam00350 360911003138 G1 box; other site 360911003139 GTP/Mg2+ binding site [chemical binding]; other site 360911003140 G2 box; other site 360911003141 Switch I region; other site 360911003142 G3 box; other site 360911003143 Switch II region; other site 360911003144 G4 box; other site 360911003145 G5 box; other site 360911003146 Part of AAA domain; Region: AAA_19; pfam13245 360911003147 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911003148 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911003149 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 360911003150 coenzyme A binding site [chemical binding]; other site 360911003151 citrylCoA binding site [chemical binding]; other site 360911003152 catalytic triad [active] 360911003153 Bacterial Ig-like domain; Region: Big_5; pfam13205 360911003154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 360911003155 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 360911003156 Probable transposase; Region: OrfB_IS605; pfam01385 360911003157 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 360911003158 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 360911003159 active site 360911003160 catalytic triad [active] 360911003161 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360911003162 NlpC/P60 family; Region: NLPC_P60; pfam00877 360911003163 anthranilate synthase component I; Provisional; Region: PRK13570 360911003164 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 360911003165 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 360911003166 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 360911003167 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 360911003168 glutamine binding [chemical binding]; other site 360911003169 catalytic triad [active] 360911003170 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 360911003171 FAD binding pocket [chemical binding]; other site 360911003172 conserved FAD binding motif [chemical binding]; other site 360911003173 phosphate binding motif [ion binding]; other site 360911003174 beta-alpha-beta structure motif; other site 360911003175 NAD binding pocket [chemical binding]; other site 360911003176 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 360911003177 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360911003178 Walker A/P-loop; other site 360911003179 ATP binding site [chemical binding]; other site 360911003180 Q-loop/lid; other site 360911003181 ABC transporter signature motif; other site 360911003182 Walker B; other site 360911003183 D-loop; other site 360911003184 H-loop/switch region; other site 360911003185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003186 ABC-ATPase subunit interface; other site 360911003187 dimer interface [polypeptide binding]; other site 360911003188 putative PBP binding regions; other site 360911003189 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360911003190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003191 ABC-ATPase subunit interface; other site 360911003192 dimer interface [polypeptide binding]; other site 360911003193 putative PBP binding regions; other site 360911003194 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 360911003195 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 360911003196 intersubunit interface [polypeptide binding]; other site 360911003197 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 360911003198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911003199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911003200 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 360911003201 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 360911003202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 360911003203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003204 NAD(P) binding site [chemical binding]; other site 360911003205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 360911003206 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 360911003207 Probable transposase; Region: OrfB_IS605; pfam01385 360911003208 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 360911003209 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 360911003210 homodimer interface [polypeptide binding]; other site 360911003211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003212 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 360911003213 dimer interface [polypeptide binding]; other site 360911003214 putative metal binding site [ion binding]; other site 360911003215 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 360911003216 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 360911003217 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 360911003218 Walker A/P-loop; other site 360911003219 ATP binding site [chemical binding]; other site 360911003220 Q-loop/lid; other site 360911003221 ABC transporter signature motif; other site 360911003222 Walker B; other site 360911003223 D-loop; other site 360911003224 H-loop/switch region; other site 360911003225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911003226 DNA-binding site [nucleotide binding]; DNA binding site 360911003227 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911003228 UTRA domain; Region: UTRA; pfam07702 360911003229 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 360911003230 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 360911003231 NAD binding site [chemical binding]; other site 360911003232 sugar binding site [chemical binding]; other site 360911003233 divalent metal binding site [ion binding]; other site 360911003234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911003235 dimer interface [polypeptide binding]; other site 360911003236 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 360911003237 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911003238 methionine cluster; other site 360911003239 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 360911003240 active site 360911003241 phosphorylation site [posttranslational modification] 360911003242 metal binding site [ion binding]; metal-binding site 360911003243 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360911003244 active site 360911003245 P-loop; other site 360911003246 phosphorylation site [posttranslational modification] 360911003247 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 360911003248 putative active site [active] 360911003249 YdjC motif; other site 360911003250 Mg binding site [ion binding]; other site 360911003251 putative homodimer interface [polypeptide binding]; other site 360911003252 AAA domain; Region: AAA_18; pfam13238 360911003253 AAA domain; Region: AAA_17; pfam13207 360911003254 Cation efflux family; Region: Cation_efflux; cl00316 360911003255 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911003256 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911003257 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911003258 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 360911003259 peptidase T-like protein; Region: PepT-like; TIGR01883 360911003260 metal binding site [ion binding]; metal-binding site 360911003261 putative dimer interface [polypeptide binding]; other site 360911003262 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 360911003263 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911003264 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 360911003265 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 360911003266 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 360911003267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360911003268 TPR motif; other site 360911003269 binding surface 360911003270 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 360911003271 classical (c) SDRs; Region: SDR_c; cd05233 360911003272 NAD(P) binding site [chemical binding]; other site 360911003273 active site 360911003274 CHASE3 domain; Region: CHASE3; cl05000 360911003275 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911003276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003277 dimerization interface [polypeptide binding]; other site 360911003278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003279 dimer interface [polypeptide binding]; other site 360911003280 putative CheW interface [polypeptide binding]; other site 360911003281 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911003282 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911003283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003284 dimerization interface [polypeptide binding]; other site 360911003285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003287 dimer interface [polypeptide binding]; other site 360911003288 putative CheW interface [polypeptide binding]; other site 360911003289 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 360911003290 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 360911003291 YvrJ protein family; Region: YvrJ; pfam12841 360911003292 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 360911003293 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 360911003294 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 360911003295 FtsX-like permease family; Region: FtsX; pfam02687 360911003296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911003297 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360911003298 Walker A/P-loop; other site 360911003299 ATP binding site [chemical binding]; other site 360911003300 Q-loop/lid; other site 360911003301 ABC transporter signature motif; other site 360911003302 Walker B; other site 360911003303 D-loop; other site 360911003304 H-loop/switch region; other site 360911003305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911003306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003307 active site 360911003308 phosphorylation site [posttranslational modification] 360911003309 intermolecular recognition site; other site 360911003310 dimerization interface [polypeptide binding]; other site 360911003311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911003312 DNA binding site [nucleotide binding] 360911003313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911003314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003315 dimer interface [polypeptide binding]; other site 360911003316 phosphorylation site [posttranslational modification] 360911003317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003318 ATP binding site [chemical binding]; other site 360911003319 Mg2+ binding site [ion binding]; other site 360911003320 G-X-G motif; other site 360911003321 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 360911003322 GAF domain; Region: GAF; pfam01590 360911003323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003324 metal binding site [ion binding]; metal-binding site 360911003325 active site 360911003326 I-site; other site 360911003327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003328 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911003329 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003330 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003331 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003332 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003333 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360911003334 NlpC/P60 family; Region: NLPC_P60; pfam00877 360911003335 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 360911003336 nucleotidyl binding site; other site 360911003337 metal binding site [ion binding]; metal-binding site 360911003338 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003339 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 360911003340 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 360911003341 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 360911003342 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360911003343 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 360911003344 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 360911003345 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 360911003346 WxL domain surface cell wall-binding; Region: WxL; pfam13731 360911003347 WxL domain surface cell wall-binding; Region: WxL; pfam13731 360911003348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911003349 Coenzyme A binding pocket [chemical binding]; other site 360911003350 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 360911003351 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 360911003352 active site 360911003353 WbqC-like protein family; Region: WbqC; pfam08889 360911003354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911003355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911003356 active site 360911003357 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 360911003358 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 360911003359 NAD binding site [chemical binding]; other site 360911003360 substrate binding site [chemical binding]; other site 360911003361 homodimer interface [polypeptide binding]; other site 360911003362 active site 360911003363 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 360911003364 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 360911003365 substrate binding site; other site 360911003366 tetramer interface; other site 360911003367 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 360911003368 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 360911003369 inhibitor-cofactor binding pocket; inhibition site 360911003370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911003371 catalytic residue [active] 360911003372 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911003373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911003374 active site 360911003375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911003376 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360911003377 NAD(P) binding site [chemical binding]; other site 360911003378 active site 360911003379 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 360911003380 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911003381 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 360911003382 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911003383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003384 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 360911003385 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 360911003386 NAD(P) binding site [chemical binding]; other site 360911003387 homodimer interface [polypeptide binding]; other site 360911003388 substrate binding site [chemical binding]; other site 360911003389 active site 360911003390 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 360911003391 Bacterial sugar transferase; Region: Bac_transf; pfam02397 360911003392 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 360911003393 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 360911003394 active site 360911003395 homodimer interface [polypeptide binding]; other site 360911003396 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360911003397 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 360911003398 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 360911003399 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 360911003400 active site 360911003401 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360911003402 putative glycosyl transferase; Provisional; Region: PRK10125 360911003403 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 360911003404 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911003405 active site turn [active] 360911003406 phosphorylation site [posttranslational modification] 360911003407 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911003408 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 360911003409 HPr interaction site; other site 360911003410 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911003411 active site 360911003412 phosphorylation site [posttranslational modification] 360911003413 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911003414 beta-galactosidase; Region: BGL; TIGR03356 360911003415 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 360911003416 active site 360911003417 catalytic residues [active] 360911003418 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 360911003419 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 360911003420 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 360911003421 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 360911003422 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 360911003423 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 360911003424 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 360911003425 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360911003426 UDP-glucose 4-epimerase; Region: PLN02240 360911003427 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 360911003428 NAD binding site [chemical binding]; other site 360911003429 homodimer interface [polypeptide binding]; other site 360911003430 active site 360911003431 substrate binding site [chemical binding]; other site 360911003432 Predicted membrane protein [Function unknown]; Region: COG4267 360911003433 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 360911003434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 360911003436 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 360911003437 NodB motif; other site 360911003438 putative active site [active] 360911003439 putative catalytic site [active] 360911003440 putative Zn binding site [ion binding]; other site 360911003441 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 360911003442 GAF domain; Region: GAF_3; pfam13492 360911003443 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 360911003444 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 360911003445 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 360911003446 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 360911003447 active site 360911003448 FMN binding site [chemical binding]; other site 360911003449 substrate binding site [chemical binding]; other site 360911003450 3Fe-4S cluster binding site [ion binding]; other site 360911003451 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360911003452 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360911003453 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360911003454 putative active site [active] 360911003455 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 360911003456 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911003457 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911003458 PAS domain; Region: PAS_9; pfam13426 360911003459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911003460 putative active site [active] 360911003461 heme pocket [chemical binding]; other site 360911003462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911003463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003464 metal binding site [ion binding]; metal-binding site 360911003465 active site 360911003466 I-site; other site 360911003467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911003469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911003470 putative substrate translocation pore; other site 360911003471 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 360911003472 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 360911003473 fructuronate transporter; Provisional; Region: PRK10034; cl15264 360911003474 GntP family permease; Region: GntP_permease; pfam02447 360911003475 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 360911003476 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 360911003477 N- and C-terminal domain interface [polypeptide binding]; other site 360911003478 active site 360911003479 catalytic site [active] 360911003480 metal binding site [ion binding]; metal-binding site 360911003481 carbohydrate binding site [chemical binding]; other site 360911003482 ATP binding site [chemical binding]; other site 360911003483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911003484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911003485 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 360911003486 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 360911003487 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911003488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003489 metal binding site [ion binding]; metal-binding site 360911003490 active site 360911003491 I-site; other site 360911003492 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 360911003493 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 360911003494 folate binding site [chemical binding]; other site 360911003495 NADP+ binding site [chemical binding]; other site 360911003496 Predicted transcriptional regulator [Transcription]; Region: COG2378 360911003497 HTH domain; Region: HTH_11; pfam08279 360911003498 WYL domain; Region: WYL; pfam13280 360911003499 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 360911003500 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911003501 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 360911003502 active site 360911003503 catalytic motif [active] 360911003504 Zn binding site [ion binding]; other site 360911003505 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360911003506 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360911003507 Walker A/P-loop; other site 360911003508 ATP binding site [chemical binding]; other site 360911003509 Q-loop/lid; other site 360911003510 ABC transporter signature motif; other site 360911003511 Walker B; other site 360911003512 D-loop; other site 360911003513 H-loop/switch region; other site 360911003514 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360911003515 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003516 ABC-ATPase subunit interface; other site 360911003517 dimer interface [polypeptide binding]; other site 360911003518 putative PBP binding regions; other site 360911003519 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360911003520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911003521 ABC-ATPase subunit interface; other site 360911003522 dimer interface [polypeptide binding]; other site 360911003523 putative PBP binding regions; other site 360911003524 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 360911003525 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360911003526 siderophore binding site; other site 360911003527 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 360911003528 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 360911003529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911003530 motif II; other site 360911003531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911003532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911003533 Coenzyme A binding pocket [chemical binding]; other site 360911003534 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911003535 MarR family; Region: MarR; pfam01047 360911003536 MarR family; Region: MarR_2; cl17246 360911003537 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 360911003538 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 360911003539 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911003540 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911003541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003542 dimerization interface [polypeptide binding]; other site 360911003543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003544 dimer interface [polypeptide binding]; other site 360911003545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003546 dimer interface [polypeptide binding]; other site 360911003547 putative CheW interface [polypeptide binding]; other site 360911003548 Uncharacterized conserved protein [Function unknown]; Region: COG0398 360911003549 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911003550 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 360911003551 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 360911003552 NodB motif; other site 360911003553 active site 360911003554 catalytic site [active] 360911003555 Zn binding site [ion binding]; other site 360911003556 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911003557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003558 dimer interface [polypeptide binding]; other site 360911003559 putative CheW interface [polypeptide binding]; other site 360911003560 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 360911003561 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 360911003562 NADP binding site [chemical binding]; other site 360911003563 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 360911003564 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 360911003565 Ligand Binding Site [chemical binding]; other site 360911003566 K+-transporting ATPase, c chain; Region: KdpC; cl00944 360911003567 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 360911003568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911003569 Soluble P-type ATPase [General function prediction only]; Region: COG4087 360911003570 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 360911003571 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911003572 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911003573 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 360911003574 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003575 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 360911003576 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911003577 Domain of unknown function (DUF305); Region: DUF305; cl17794 360911003578 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911003579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911003580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003581 active site 360911003582 phosphorylation site [posttranslational modification] 360911003583 intermolecular recognition site; other site 360911003584 dimerization interface [polypeptide binding]; other site 360911003585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911003586 DNA binding site [nucleotide binding] 360911003587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911003588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003589 dimerization interface [polypeptide binding]; other site 360911003590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003591 dimer interface [polypeptide binding]; other site 360911003592 phosphorylation site [posttranslational modification] 360911003593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003594 ATP binding site [chemical binding]; other site 360911003595 Mg2+ binding site [ion binding]; other site 360911003596 G-X-G motif; other site 360911003597 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 360911003598 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911003599 Soluble P-type ATPase [General function prediction only]; Region: COG4087 360911003600 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 360911003601 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 360911003602 Multicopper oxidase; Region: Cu-oxidase; pfam00394 360911003603 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 360911003604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 360911003605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003606 dimer interface [polypeptide binding]; other site 360911003607 phosphorylation site [posttranslational modification] 360911003608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003609 ATP binding site [chemical binding]; other site 360911003610 Mg2+ binding site [ion binding]; other site 360911003611 G-X-G motif; other site 360911003612 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911003613 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911003614 Ca binding site [ion binding]; other site 360911003615 active site 360911003616 catalytic site [active] 360911003617 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 360911003618 beta-phosphoglucomutase; Region: bPGM; TIGR01990 360911003619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911003620 motif II; other site 360911003621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911003622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003623 dimer interface [polypeptide binding]; other site 360911003624 conserved gate region; other site 360911003625 putative PBP binding loops; other site 360911003626 ABC-ATPase subunit interface; other site 360911003627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003628 dimer interface [polypeptide binding]; other site 360911003629 conserved gate region; other site 360911003630 putative PBP binding loops; other site 360911003631 ABC-ATPase subunit interface; other site 360911003632 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911003633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360911003634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911003635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911003636 DNA binding site [nucleotide binding] 360911003637 domain linker motif; other site 360911003638 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360911003639 dimerization interface [polypeptide binding]; other site 360911003640 ligand binding site [chemical binding]; other site 360911003641 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 360911003642 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 360911003643 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 360911003644 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 360911003645 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 360911003646 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 360911003647 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 360911003648 substrate binding [chemical binding]; other site 360911003649 active site 360911003650 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 360911003651 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 360911003652 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911003653 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003654 metal binding site [ion binding]; metal-binding site 360911003655 active site 360911003656 I-site; other site 360911003657 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 360911003658 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 360911003659 active site 360911003660 catalytic site [active] 360911003661 metal binding site [ion binding]; metal-binding site 360911003662 dimer interface [polypeptide binding]; other site 360911003663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911003664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360911003665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911003666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003667 dimer interface [polypeptide binding]; other site 360911003668 conserved gate region; other site 360911003669 putative PBP binding loops; other site 360911003670 ABC-ATPase subunit interface; other site 360911003671 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 360911003672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911003673 putative PBP binding loops; other site 360911003674 dimer interface [polypeptide binding]; other site 360911003675 ABC-ATPase subunit interface; other site 360911003676 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360911003677 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360911003678 Walker A/P-loop; other site 360911003679 ATP binding site [chemical binding]; other site 360911003680 Q-loop/lid; other site 360911003681 ABC transporter signature motif; other site 360911003682 Walker B; other site 360911003683 D-loop; other site 360911003684 H-loop/switch region; other site 360911003685 TOBE domain; Region: TOBE_2; pfam08402 360911003686 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 360911003687 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 360911003688 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 360911003689 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 360911003690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911003691 S-adenosylmethionine binding site [chemical binding]; other site 360911003692 GAF domain; Region: GAF; cl17456 360911003693 GAF domain; Region: GAF_2; pfam13185 360911003694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911003695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911003696 metal binding site [ion binding]; metal-binding site 360911003697 active site 360911003698 I-site; other site 360911003699 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 360911003700 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 360911003701 putative active site cavity [active] 360911003702 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360911003703 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360911003704 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360911003705 putative active site [active] 360911003706 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 360911003707 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911003708 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911003709 active site turn [active] 360911003710 phosphorylation site [posttranslational modification] 360911003711 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 360911003712 active site 360911003713 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 360911003714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003715 dimerization interface [polypeptide binding]; other site 360911003716 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360911003717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003718 dimer interface [polypeptide binding]; other site 360911003719 putative CheW interface [polypeptide binding]; other site 360911003720 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 360911003721 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 360911003722 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 360911003723 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 360911003724 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 360911003725 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 360911003726 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360911003727 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360911003728 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 360911003729 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360911003730 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 360911003731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360911003732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003733 dimer interface [polypeptide binding]; other site 360911003734 phosphorylation site [posttranslational modification] 360911003735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003736 ATP binding site [chemical binding]; other site 360911003737 Mg2+ binding site [ion binding]; other site 360911003738 G-X-G motif; other site 360911003739 Histidine kinase; Region: His_kinase; pfam06580 360911003740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003741 ATP binding site [chemical binding]; other site 360911003742 Mg2+ binding site [ion binding]; other site 360911003743 G-X-G motif; other site 360911003744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003745 Response regulator receiver domain; Region: Response_reg; pfam00072 360911003746 active site 360911003747 phosphorylation site [posttranslational modification] 360911003748 intermolecular recognition site; other site 360911003749 dimerization interface [polypeptide binding]; other site 360911003750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 360911003751 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 360911003752 classical (c) SDRs; Region: SDR_c; cd05233 360911003753 NAD(P) binding site [chemical binding]; other site 360911003754 active site 360911003755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911003756 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911003757 active site 360911003758 rod shape-determining protein Mbl; Provisional; Region: PRK13928 360911003759 MreB and similar proteins; Region: MreB_like; cd10225 360911003760 nucleotide binding site [chemical binding]; other site 360911003761 Mg binding site [ion binding]; other site 360911003762 putative protofilament interaction site [polypeptide binding]; other site 360911003763 RodZ interaction site [polypeptide binding]; other site 360911003764 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 360911003765 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 360911003766 hinge; other site 360911003767 active site 360911003768 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 360911003769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003770 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 360911003771 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 360911003772 gamma subunit interface [polypeptide binding]; other site 360911003773 epsilon subunit interface [polypeptide binding]; other site 360911003774 LBP interface [polypeptide binding]; other site 360911003775 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 360911003776 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 360911003777 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 360911003778 alpha subunit interaction interface [polypeptide binding]; other site 360911003779 Walker A motif; other site 360911003780 ATP binding site [chemical binding]; other site 360911003781 Walker B motif; other site 360911003782 inhibitor binding site; inhibition site 360911003783 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 360911003784 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 360911003785 core domain interface [polypeptide binding]; other site 360911003786 delta subunit interface [polypeptide binding]; other site 360911003787 epsilon subunit interface [polypeptide binding]; other site 360911003788 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 360911003789 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 360911003790 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 360911003791 beta subunit interaction interface [polypeptide binding]; other site 360911003792 Walker A motif; other site 360911003793 ATP binding site [chemical binding]; other site 360911003794 Walker B motif; other site 360911003795 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 360911003796 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 360911003797 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 360911003798 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 360911003799 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 360911003800 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 360911003801 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 360911003802 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 360911003803 ATP synthase I chain; Region: ATP_synt_I; pfam03899 360911003804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911003805 active site 360911003806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911003807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911003808 dimerization interface [polypeptide binding]; other site 360911003809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911003810 dimer interface [polypeptide binding]; other site 360911003811 phosphorylation site [posttranslational modification] 360911003812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911003813 ATP binding site [chemical binding]; other site 360911003814 Mg2+ binding site [ion binding]; other site 360911003815 G-X-G motif; other site 360911003816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911003817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003818 active site 360911003819 phosphorylation site [posttranslational modification] 360911003820 intermolecular recognition site; other site 360911003821 dimerization interface [polypeptide binding]; other site 360911003822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911003823 DNA binding site [nucleotide binding] 360911003824 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 360911003825 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 360911003826 dimer interface [polypeptide binding]; other site 360911003827 active site 360911003828 glycine-pyridoxal phosphate binding site [chemical binding]; other site 360911003829 folate binding site [chemical binding]; other site 360911003830 Putative esterase; Region: Esterase; pfam00756 360911003831 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 360911003832 MarR family; Region: MarR; pfam01047 360911003833 MarR family; Region: MarR_2; cl17246 360911003834 classical (c) SDRs; Region: SDR_c; cd05233 360911003835 NAD(P) binding site [chemical binding]; other site 360911003836 active site 360911003837 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 360911003838 Predicted transcriptional regulators [Transcription]; Region: COG1733 360911003839 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 360911003840 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 360911003841 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 360911003842 potential catalytic triad [active] 360911003843 conserved cys residue [active] 360911003844 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 360911003845 hypothetical protein; Provisional; Region: PRK13690 360911003846 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 360911003847 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 360911003848 Low molecular weight phosphatase family; Region: LMWPc; cd00115 360911003849 active site 360911003850 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 360911003851 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 360911003852 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 360911003853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911003854 S-adenosylmethionine binding site [chemical binding]; other site 360911003855 peptide chain release factor 1; Validated; Region: prfA; PRK00591 360911003856 This domain is found in peptide chain release factors; Region: PCRF; smart00937 360911003857 RF-1 domain; Region: RF-1; pfam00472 360911003858 thymidine kinase; Provisional; Region: PRK04296 360911003859 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911003860 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360911003861 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 360911003862 transcription termination factor Rho; Provisional; Region: rho; PRK09376 360911003863 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 360911003864 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 360911003865 RNA binding site [nucleotide binding]; other site 360911003866 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360911003867 Walker A motif; other site 360911003868 ATP binding site [chemical binding]; other site 360911003869 Walker B motif; other site 360911003870 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911003871 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360911003872 NlpC/P60 family; Region: NLPC_P60; pfam00877 360911003873 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 360911003874 ABC-2 type transporter; Region: ABC2_membrane; cl17235 360911003875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911003876 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 360911003877 Walker A/P-loop; other site 360911003878 ATP binding site [chemical binding]; other site 360911003879 Q-loop/lid; other site 360911003880 ABC transporter signature motif; other site 360911003881 Walker B; other site 360911003882 D-loop; other site 360911003883 H-loop/switch region; other site 360911003884 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 360911003885 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 360911003886 putative active site [active] 360911003887 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 360911003888 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 360911003889 hinge; other site 360911003890 active site 360911003891 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 360911003892 active site 360911003893 intersubunit interactions; other site 360911003894 catalytic residue [active] 360911003895 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 360911003896 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 360911003897 intersubunit interface [polypeptide binding]; other site 360911003898 active site 360911003899 zinc binding site [ion binding]; other site 360911003900 Na+ binding site [ion binding]; other site 360911003901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911003902 Response regulator receiver domain; Region: Response_reg; pfam00072 360911003903 active site 360911003904 phosphorylation site [posttranslational modification] 360911003905 intermolecular recognition site; other site 360911003906 dimerization interface [polypeptide binding]; other site 360911003907 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 360911003908 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 360911003909 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 360911003910 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 360911003911 putative active site [active] 360911003912 putative FMN binding site [chemical binding]; other site 360911003913 putative substrate binding site [chemical binding]; other site 360911003914 putative catalytic residue [active] 360911003915 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 360911003916 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 360911003917 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 360911003918 NodB motif; other site 360911003919 active site 360911003920 catalytic site [active] 360911003921 Zn binding site [ion binding]; other site 360911003922 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911003923 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911003924 Coenzyme A binding pocket [chemical binding]; other site 360911003925 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911003926 CTP synthetase; Validated; Region: pyrG; PRK05380 360911003927 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 360911003928 Catalytic site [active] 360911003929 active site 360911003930 UTP binding site [chemical binding]; other site 360911003931 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 360911003932 active site 360911003933 putative oxyanion hole; other site 360911003934 catalytic triad [active] 360911003935 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 360911003936 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 360911003937 heme-binding site [chemical binding]; other site 360911003938 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911003939 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911003940 dimer interface [polypeptide binding]; other site 360911003941 putative CheW interface [polypeptide binding]; other site 360911003942 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 360911003943 4Fe-4S binding domain; Region: Fer4; cl02805 360911003944 Cysteine-rich domain; Region: CCG; pfam02754 360911003945 Cysteine-rich domain; Region: CCG; pfam02754 360911003946 Predicted acetyltransferase [General function prediction only]; Region: COG3981 360911003947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911003948 Coenzyme A binding pocket [chemical binding]; other site 360911003949 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 360911003950 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911003951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911003952 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 360911003953 conserved cys residue [active] 360911003954 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911003955 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911003956 Ca binding site [ion binding]; other site 360911003957 active site 360911003958 catalytic site [active] 360911003959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911003960 Coenzyme A binding pocket [chemical binding]; other site 360911003961 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 360911003962 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911003963 DNA binding residues [nucleotide binding] 360911003964 dimer interface [polypeptide binding]; other site 360911003965 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 360911003966 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 360911003967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911003968 putative ADP-binding pocket [chemical binding]; other site 360911003969 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 360911003970 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360911003971 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 360911003972 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 360911003973 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 360911003974 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 360911003975 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 360911003976 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360911003977 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 360911003978 putative NAD(P) binding site [chemical binding]; other site 360911003979 active site 360911003980 putative substrate binding site [chemical binding]; other site 360911003981 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 360911003982 TrkA-N domain; Region: TrkA_N; pfam02254 360911003983 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 360911003984 NAD(P) binding site [chemical binding]; other site 360911003985 homodimer interface [polypeptide binding]; other site 360911003986 substrate binding site [chemical binding]; other site 360911003987 active site 360911003988 Domain of unknown function (DUF897); Region: DUF897; cl01312 360911003989 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 360911003990 agmatinase; Region: agmatinase; TIGR01230 360911003991 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 360911003992 putative active site [active] 360911003993 Mn binding site [ion binding]; other site 360911003994 spermidine synthase; Provisional; Region: PRK00811 360911003995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911003996 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911003997 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 360911003998 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 360911003999 Cl- selectivity filter; other site 360911004000 Cl- binding residues [ion binding]; other site 360911004001 pore gating glutamate residue; other site 360911004002 dimer interface [polypeptide binding]; other site 360911004003 cardiolipin synthetase; Reviewed; Region: PRK12452 360911004004 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911004005 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911004006 putative active site [active] 360911004007 catalytic site [active] 360911004008 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911004009 putative active site [active] 360911004010 catalytic site [active] 360911004011 Uncharacterized conserved protein [Function unknown]; Region: COG0398 360911004012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911004013 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 360911004014 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 360911004015 YwhD family; Region: YwhD; pfam08741 360911004016 Uncharacterized conserved protein [Function unknown]; Region: COG3589 360911004017 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 360911004018 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911004019 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 360911004020 active site turn [active] 360911004021 phosphorylation site [posttranslational modification] 360911004022 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911004023 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 360911004024 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 360911004025 putative active site [active] 360911004026 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911004027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004028 Coenzyme A binding pocket [chemical binding]; other site 360911004029 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360911004030 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360911004031 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360911004032 putative active site [active] 360911004033 Predicted metalloprotease [General function prediction only]; Region: COG2321 360911004034 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 360911004035 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 360911004036 active site 1 [active] 360911004037 dimer interface [polypeptide binding]; other site 360911004038 hexamer interface [polypeptide binding]; other site 360911004039 active site 2 [active] 360911004040 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 360911004041 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911004042 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 360911004043 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 360911004044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911004045 Zn2+ binding site [ion binding]; other site 360911004046 Mg2+ binding site [ion binding]; other site 360911004047 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 360911004048 EDD domain protein, DegV family; Region: DegV; TIGR00762 360911004049 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 360911004050 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 360911004051 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 360911004052 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 360911004053 lipoyl synthase; Provisional; Region: PRK05481 360911004054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911004055 FeS/SAM binding site; other site 360911004056 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 360911004057 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 360911004058 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 360911004059 putative di-iron ligands [ion binding]; other site 360911004060 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 360911004061 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 360911004062 active site 360911004063 Na/Ca binding site [ion binding]; other site 360911004064 catalytic site [active] 360911004065 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 360911004066 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911004067 Transcriptional regulator PadR-like family; Region: PadR; cl17335 360911004068 HD domain; Region: HD_3; cl17350 360911004069 HD domain; Region: HD_3; cl17350 360911004070 Ion channel; Region: Ion_trans_2; pfam07885 360911004071 TrkA-N domain; Region: TrkA_N; pfam02254 360911004072 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 360911004073 Predicted membrane protein [Function unknown]; Region: COG3766 360911004074 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 360911004075 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 360911004076 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 360911004077 heme-binding site [chemical binding]; other site 360911004078 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 360911004079 FAD binding pocket [chemical binding]; other site 360911004080 FAD binding motif [chemical binding]; other site 360911004081 phosphate binding motif [ion binding]; other site 360911004082 beta-alpha-beta structure motif; other site 360911004083 NAD binding pocket [chemical binding]; other site 360911004084 Heme binding pocket [chemical binding]; other site 360911004085 Transcriptional regulator; Region: Rrf2; cl17282 360911004086 Predicted transcriptional regulator [Transcription]; Region: COG1959 360911004087 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 360911004088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004089 Zn binding site [ion binding]; other site 360911004090 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 360911004091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004092 Zn binding site [ion binding]; other site 360911004093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911004094 non-specific DNA binding site [nucleotide binding]; other site 360911004095 salt bridge; other site 360911004096 sequence-specific DNA binding site [nucleotide binding]; other site 360911004097 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 360911004098 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 360911004099 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 360911004100 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 360911004101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911004102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911004103 dimerization interface [polypeptide binding]; other site 360911004104 putative DNA binding site [nucleotide binding]; other site 360911004105 putative Zn2+ binding site [ion binding]; other site 360911004106 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 360911004107 putative hydrophobic ligand binding site [chemical binding]; other site 360911004108 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 360911004109 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911004110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911004111 catalytic residue [active] 360911004112 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 360911004113 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911004114 putative NAD(P) binding site [chemical binding]; other site 360911004115 substrate binding site [chemical binding]; other site 360911004116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911004118 active site 360911004119 metal binding site [ion binding]; metal-binding site 360911004120 Predicted transcriptional regulators [Transcription]; Region: COG1733 360911004121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911004122 dimerization interface [polypeptide binding]; other site 360911004123 putative DNA binding site [nucleotide binding]; other site 360911004124 putative Zn2+ binding site [ion binding]; other site 360911004125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004126 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911004127 active site 360911004128 metal binding site [ion binding]; metal-binding site 360911004129 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911004130 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911004131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360911004132 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360911004133 TM-ABC transporter signature motif; other site 360911004134 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360911004135 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360911004136 Walker A/P-loop; other site 360911004137 ATP binding site [chemical binding]; other site 360911004138 Q-loop/lid; other site 360911004139 ABC transporter signature motif; other site 360911004140 Walker B; other site 360911004141 D-loop; other site 360911004142 H-loop/switch region; other site 360911004143 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360911004144 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 360911004145 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360911004146 putative ligand binding site [chemical binding]; other site 360911004147 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 360911004148 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 360911004149 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 360911004150 Phosphotransferase enzyme family; Region: APH; pfam01636 360911004151 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 360911004152 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 360911004153 dimer interface [polypeptide binding]; other site 360911004154 active site 360911004155 catalytic residue [active] 360911004156 metal binding site [ion binding]; metal-binding site 360911004157 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 360911004158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004159 active site 360911004160 motif I; other site 360911004161 motif II; other site 360911004162 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 360911004163 intersubunit interface [polypeptide binding]; other site 360911004164 active site 360911004165 Zn2+ binding site [ion binding]; other site 360911004166 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 360911004167 Cupin domain; Region: Cupin_2; pfam07883 360911004168 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 360911004169 putative GTP cyclohydrolase; Provisional; Region: PRK13674 360911004170 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911004171 active site residue [active] 360911004172 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 360911004173 putative heme peroxidase; Provisional; Region: PRK12276 360911004174 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911004175 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 360911004176 TrkA-C domain; Region: TrkA_C; pfam02080 360911004177 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 360911004178 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 360911004179 substrate binding site [chemical binding]; other site 360911004180 active site 360911004181 catalytic residues [active] 360911004182 heterodimer interface [polypeptide binding]; other site 360911004183 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 360911004184 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 360911004185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911004186 catalytic residue [active] 360911004187 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 360911004188 active site 360911004189 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 360911004190 active site 360911004191 ribulose/triose binding site [chemical binding]; other site 360911004192 phosphate binding site [ion binding]; other site 360911004193 substrate (anthranilate) binding pocket [chemical binding]; other site 360911004194 product (indole) binding pocket [chemical binding]; other site 360911004195 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 360911004196 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360911004197 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360911004198 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 360911004199 Tropomyosin like; Region: Tropomyosin_1; pfam12718 360911004200 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 360911004201 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911004202 Protein of unknown function (DUF423); Region: DUF423; pfam04241 360911004203 Predicted membrane protein [Function unknown]; Region: COG2860 360911004204 UPF0126 domain; Region: UPF0126; pfam03458 360911004205 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 360911004206 ABC1 family; Region: ABC1; cl17513 360911004207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911004208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004209 Coenzyme A binding pocket [chemical binding]; other site 360911004210 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911004211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911004212 catalytic residue [active] 360911004213 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 360911004214 succinic semialdehyde dehydrogenase; Region: PLN02278 360911004215 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 360911004216 tetramerization interface [polypeptide binding]; other site 360911004217 NAD(P) binding site [chemical binding]; other site 360911004218 catalytic residues [active] 360911004219 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 360911004220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004221 motif II; other site 360911004222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911004223 active site residue [active] 360911004224 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 360911004225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 360911004226 methionine sulfoxide reductase A; Provisional; Region: PRK14054 360911004227 methionine sulfoxide reductase B; Provisional; Region: PRK00222 360911004228 SelR domain; Region: SelR; pfam01641 360911004229 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 360911004230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911004231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911004232 metal binding site [ion binding]; metal-binding site 360911004233 active site 360911004234 I-site; other site 360911004235 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 360911004236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911004237 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 360911004238 Walker A/P-loop; other site 360911004239 ATP binding site [chemical binding]; other site 360911004240 Q-loop/lid; other site 360911004241 ABC transporter signature motif; other site 360911004242 Walker B; other site 360911004243 D-loop; other site 360911004244 H-loop/switch region; other site 360911004245 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 360911004246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911004247 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 360911004248 Walker A/P-loop; other site 360911004249 ATP binding site [chemical binding]; other site 360911004250 Q-loop/lid; other site 360911004251 ABC transporter signature motif; other site 360911004252 Walker B; other site 360911004253 D-loop; other site 360911004254 H-loop/switch region; other site 360911004255 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 360911004256 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911004257 ligand binding site [chemical binding]; other site 360911004258 flexible hinge region; other site 360911004259 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 360911004260 putative switch regulator; other site 360911004261 non-specific DNA interactions [nucleotide binding]; other site 360911004262 DNA binding site [nucleotide binding] 360911004263 sequence specific DNA binding site [nucleotide binding]; other site 360911004264 putative cAMP binding site [chemical binding]; other site 360911004265 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 360911004266 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 360911004267 putative active site [active] 360911004268 putative catalytic site [active] 360911004269 carbamate kinase; Reviewed; Region: PRK12686 360911004270 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 360911004271 putative substrate binding site [chemical binding]; other site 360911004272 nucleotide binding site [chemical binding]; other site 360911004273 nucleotide binding site [chemical binding]; other site 360911004274 homodimer interface [polypeptide binding]; other site 360911004275 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 360911004276 ornithine carbamoyltransferase; Validated; Region: PRK02102 360911004277 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360911004278 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 360911004279 arginine deiminase; Provisional; Region: PRK01388 360911004280 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 360911004281 MgtE intracellular N domain; Region: MgtE_N; smart00924 360911004282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 360911004283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 360911004284 Divalent cation transporter; Region: MgtE; pfam01769 360911004285 putative transporter; Provisional; Region: PRK10484 360911004286 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 360911004287 Na binding site [ion binding]; other site 360911004288 PAS fold; Region: PAS_3; pfam08447 360911004289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911004290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911004291 metal binding site [ion binding]; metal-binding site 360911004292 active site 360911004293 I-site; other site 360911004294 Beta-lactamase; Region: Beta-lactamase; pfam00144 360911004295 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 360911004296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911004297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004298 Coenzyme A binding pocket [chemical binding]; other site 360911004299 short chain dehydrogenase; Provisional; Region: PRK06924 360911004300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004301 NAD(P) binding site [chemical binding]; other site 360911004302 active site 360911004303 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 360911004304 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 360911004305 NADP binding site [chemical binding]; other site 360911004306 dimer interface [polypeptide binding]; other site 360911004307 Heat induced stress protein YflT; Region: YflT; pfam11181 360911004308 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 360911004309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911004310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911004311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911004312 hypothetical protein; Provisional; Region: PRK07758 360911004313 WYL domain; Region: WYL; cl14852 360911004314 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 360911004315 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 360911004316 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 360911004317 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 360911004318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911004320 DNA binding residues [nucleotide binding] 360911004321 Putative zinc-finger; Region: zf-HC2; pfam13490 360911004322 Anti-sigma-K factor rskA; Region: RskA; pfam10099 360911004323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360911004324 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360911004325 EamA-like transporter family; Region: EamA; pfam00892 360911004326 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 360911004327 EamA-like transporter family; Region: EamA; pfam00892 360911004328 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911004329 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911004330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911004331 ABC transporter; Region: ABC_tran_2; pfam12848 360911004332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911004333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004334 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911004335 active site 360911004336 motif I; other site 360911004337 motif II; other site 360911004338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911004340 kynureninase; Region: kynureninase; TIGR01814 360911004341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911004342 catalytic residue [active] 360911004343 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 360911004344 Putative cyclase; Region: Cyclase; cl00814 360911004345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911004346 active site 360911004347 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360911004348 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 360911004349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 360911004350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 360911004351 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360911004352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 360911004353 active site 360911004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911004355 Response regulator receiver domain; Region: Response_reg; pfam00072 360911004356 active site 360911004357 phosphorylation site [posttranslational modification] 360911004358 intermolecular recognition site; other site 360911004359 dimerization interface [polypeptide binding]; other site 360911004360 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 360911004361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360911004362 active site 360911004363 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 360911004364 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 360911004365 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 360911004366 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 360911004367 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 360911004368 ligand binding site [chemical binding]; other site 360911004369 dimerization interface [polypeptide binding]; other site 360911004370 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360911004371 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360911004372 TM-ABC transporter signature motif; other site 360911004373 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360911004374 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360911004375 Walker A/P-loop; other site 360911004376 ATP binding site [chemical binding]; other site 360911004377 Q-loop/lid; other site 360911004378 ABC transporter signature motif; other site 360911004379 Walker B; other site 360911004380 D-loop; other site 360911004381 H-loop/switch region; other site 360911004382 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360911004383 D-ribose pyranase; Provisional; Region: PRK11797 360911004384 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360911004385 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 360911004386 substrate binding site [chemical binding]; other site 360911004387 dimer interface [polypeptide binding]; other site 360911004388 ATP binding site [chemical binding]; other site 360911004389 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911004390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911004391 DNA binding site [nucleotide binding] 360911004392 domain linker motif; other site 360911004393 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 360911004394 dimerization interface [polypeptide binding]; other site 360911004395 ligand binding site [chemical binding]; other site 360911004396 sodium binding site [ion binding]; other site 360911004397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911004398 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911004399 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 360911004400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 360911004401 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911004402 OsmC-like protein; Region: OsmC; pfam02566 360911004403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911004404 PAS domain; Region: PAS_9; pfam13426 360911004405 putative active site [active] 360911004406 heme pocket [chemical binding]; other site 360911004407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911004408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911004409 metal binding site [ion binding]; metal-binding site 360911004410 active site 360911004411 I-site; other site 360911004412 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 360911004413 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911004414 NAD(P) binding site [chemical binding]; other site 360911004415 putative active site [active] 360911004416 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 360911004417 thiamine phosphate binding site [chemical binding]; other site 360911004418 active site 360911004419 pyrophosphate binding site [ion binding]; other site 360911004420 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 360911004421 dimer interface [polypeptide binding]; other site 360911004422 substrate binding site [chemical binding]; other site 360911004423 ATP binding site [chemical binding]; other site 360911004424 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 360911004425 substrate binding site [chemical binding]; other site 360911004426 multimerization interface [polypeptide binding]; other site 360911004427 ATP binding site [chemical binding]; other site 360911004428 Putative transcription activator [Transcription]; Region: TenA; COG0819 360911004429 Ion channel; Region: Ion_trans_2; pfam07885 360911004430 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 360911004431 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 360911004432 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 360911004433 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360911004434 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 360911004435 nudix motif; other site 360911004436 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 360911004437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911004438 motif II; other site 360911004439 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 360911004440 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360911004441 NAD(P) binding site [chemical binding]; other site 360911004442 catalytic residues [active] 360911004443 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 360911004444 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 360911004445 PhnA protein; Region: PhnA; pfam03831 360911004446 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 360911004447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004448 Coenzyme A binding pocket [chemical binding]; other site 360911004449 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 360911004450 dimerization interface [polypeptide binding]; other site 360911004451 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 360911004452 active site 360911004453 substrate binding site [chemical binding]; other site 360911004454 ATP binding site [chemical binding]; other site 360911004455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911004456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911004457 active site 360911004458 catalytic tetrad [active] 360911004459 Pirin-related protein [General function prediction only]; Region: COG1741 360911004460 Pirin; Region: Pirin; pfam02678 360911004461 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 360911004462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004463 Coenzyme A binding pocket [chemical binding]; other site 360911004464 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 360911004465 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 360911004466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 360911004467 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911004468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004469 Coenzyme A binding pocket [chemical binding]; other site 360911004470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 360911004471 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911004472 nudix motif; other site 360911004473 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 360911004474 putative dimer interface [polypeptide binding]; other site 360911004475 catalytic triad [active] 360911004476 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360911004477 classical (c) SDRs; Region: SDR_c; cd05233 360911004478 NAD(P) binding site [chemical binding]; other site 360911004479 active site 360911004480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004481 Coenzyme A binding pocket [chemical binding]; other site 360911004482 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911004483 nudix motif; other site 360911004484 Uncharacterized conserved protein [Function unknown]; Region: COG3268 360911004485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911004486 NAD(P) binding site [chemical binding]; other site 360911004487 Predicted flavoprotein [General function prediction only]; Region: COG0431 360911004488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360911004489 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 360911004490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004491 Zn binding site [ion binding]; other site 360911004492 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 360911004493 Zn binding site [ion binding]; other site 360911004494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911004495 MarR family; Region: MarR; pfam01047 360911004496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004497 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911004498 Coenzyme A binding pocket [chemical binding]; other site 360911004499 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 360911004500 Chloramphenicol acetyltransferase; Region: CAT; cl02008 360911004501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911004502 binding surface 360911004503 TPR motif; other site 360911004504 TPR repeat; Region: TPR_11; pfam13414 360911004505 Protein of unknown function (DUF402); Region: DUF402; cl00979 360911004506 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911004507 Protein of unknown function DUF58; Region: DUF58; pfam01882 360911004508 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911004509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004510 Walker A motif; other site 360911004511 ATP binding site [chemical binding]; other site 360911004512 Walker B motif; other site 360911004513 arginine finger; other site 360911004514 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 360911004515 Phosphotransferase enzyme family; Region: APH; pfam01636 360911004516 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 360911004517 active site 360911004518 ATP binding site [chemical binding]; other site 360911004519 substrate binding site [chemical binding]; other site 360911004520 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 360911004521 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911004522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911004523 Coenzyme A binding pocket [chemical binding]; other site 360911004524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004525 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911004526 active site 360911004527 metal binding site [ion binding]; metal-binding site 360911004528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911004529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911004530 active site 360911004531 metal binding site [ion binding]; metal-binding site 360911004532 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 360911004533 Sulfatase; Region: Sulfatase; pfam00884 360911004534 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 360911004535 dimer interface [polypeptide binding]; other site 360911004536 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 360911004537 dimer interface [polypeptide binding]; other site 360911004538 Uncharacterized conserved protein [Function unknown]; Region: COG1359 360911004539 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 360911004540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911004541 dimerization interface [polypeptide binding]; other site 360911004542 putative Zn2+ binding site [ion binding]; other site 360911004543 putative DNA binding site [nucleotide binding]; other site 360911004544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911004545 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 360911004546 Protein of unknown function (DUF975); Region: DUF975; cl10504 360911004547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911004548 salt bridge; other site 360911004549 non-specific DNA binding site [nucleotide binding]; other site 360911004550 sequence-specific DNA binding site [nucleotide binding]; other site 360911004551 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 360911004552 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 360911004553 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 360911004554 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 360911004555 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 360911004556 glutaminase active site [active] 360911004557 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 360911004558 dimer interface [polypeptide binding]; other site 360911004559 active site 360911004560 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 360911004561 dimer interface [polypeptide binding]; other site 360911004562 active site 360911004563 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 360911004564 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 360911004565 active site 360911004566 substrate binding site [chemical binding]; other site 360911004567 metal binding site [ion binding]; metal-binding site 360911004568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 360911004569 YbbR-like protein; Region: YbbR; pfam07949 360911004570 YbbR-like protein; Region: YbbR; pfam07949 360911004571 Uncharacterized conserved protein [Function unknown]; Region: COG1624 360911004572 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 360911004573 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 360911004574 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 360911004575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911004577 DNA binding residues [nucleotide binding] 360911004578 Arginase family; Region: Arginase; cd09989 360911004579 active site 360911004580 Mn binding site [ion binding]; other site 360911004581 oligomer interface [polypeptide binding]; other site 360911004582 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 360911004583 Domain of unknown function DUF59; Region: DUF59; cl00941 360911004584 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 360911004585 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 360911004586 Walker A motif; other site 360911004587 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 360911004588 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 360911004589 23S rRNA interface [nucleotide binding]; other site 360911004590 L3 interface [polypeptide binding]; other site 360911004591 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 360911004592 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 360911004593 dimerization interface 3.5A [polypeptide binding]; other site 360911004594 active site 360911004595 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 360911004596 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 360911004597 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 360911004598 Walker A/P-loop; other site 360911004599 ATP binding site [chemical binding]; other site 360911004600 Q-loop/lid; other site 360911004601 ABC transporter signature motif; other site 360911004602 Walker B; other site 360911004603 D-loop; other site 360911004604 H-loop/switch region; other site 360911004605 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 360911004606 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 360911004607 Walker A/P-loop; other site 360911004608 ATP binding site [chemical binding]; other site 360911004609 Q-loop/lid; other site 360911004610 ABC transporter signature motif; other site 360911004611 Walker B; other site 360911004612 D-loop; other site 360911004613 H-loop/switch region; other site 360911004614 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 360911004615 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 360911004616 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 360911004617 alphaNTD homodimer interface [polypeptide binding]; other site 360911004618 alphaNTD - beta interaction site [polypeptide binding]; other site 360911004619 alphaNTD - beta' interaction site [polypeptide binding]; other site 360911004620 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 360911004621 30S ribosomal protein S11; Validated; Region: PRK05309 360911004622 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 360911004623 30S ribosomal protein S13; Region: bact_S13; TIGR03631 360911004624 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 360911004625 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 360911004626 rRNA binding site [nucleotide binding]; other site 360911004627 predicted 30S ribosome binding site; other site 360911004628 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 360911004629 active site 360911004630 adenylate kinase; Reviewed; Region: adk; PRK00279 360911004631 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 360911004632 AMP-binding site [chemical binding]; other site 360911004633 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 360911004634 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 360911004635 SecY translocase; Region: SecY; pfam00344 360911004636 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 360911004637 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 360911004638 23S rRNA binding site [nucleotide binding]; other site 360911004639 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 360911004640 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 360911004641 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 360911004642 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 360911004643 23S rRNA interface [nucleotide binding]; other site 360911004644 5S rRNA interface [nucleotide binding]; other site 360911004645 L27 interface [polypeptide binding]; other site 360911004646 L5 interface [polypeptide binding]; other site 360911004647 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 360911004648 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 360911004649 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 360911004650 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 360911004651 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 360911004652 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 360911004653 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 360911004654 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 360911004655 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 360911004656 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 360911004657 RNA binding site [nucleotide binding]; other site 360911004658 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 360911004659 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 360911004660 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 360911004661 23S rRNA interface [nucleotide binding]; other site 360911004662 putative translocon interaction site; other site 360911004663 signal recognition particle (SRP54) interaction site; other site 360911004664 L23 interface [polypeptide binding]; other site 360911004665 trigger factor interaction site; other site 360911004666 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 360911004667 23S rRNA interface [nucleotide binding]; other site 360911004668 5S rRNA interface [nucleotide binding]; other site 360911004669 putative antibiotic binding site [chemical binding]; other site 360911004670 L25 interface [polypeptide binding]; other site 360911004671 L27 interface [polypeptide binding]; other site 360911004672 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 360911004673 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 360911004674 G-X-X-G motif; other site 360911004675 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 360911004676 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 360911004677 putative translocon binding site; other site 360911004678 protein-rRNA interface [nucleotide binding]; other site 360911004679 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 360911004680 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 360911004681 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 360911004682 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 360911004683 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 360911004684 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 360911004685 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 360911004686 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 360911004687 elongation factor Tu; Reviewed; Region: PRK00049 360911004688 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 360911004689 G1 box; other site 360911004690 GEF interaction site [polypeptide binding]; other site 360911004691 GTP/Mg2+ binding site [chemical binding]; other site 360911004692 Switch I region; other site 360911004693 G2 box; other site 360911004694 G3 box; other site 360911004695 Switch II region; other site 360911004696 G4 box; other site 360911004697 G5 box; other site 360911004698 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 360911004699 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 360911004700 Antibiotic Binding Site [chemical binding]; other site 360911004701 elongation factor G; Reviewed; Region: PRK00007 360911004702 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 360911004703 G1 box; other site 360911004704 putative GEF interaction site [polypeptide binding]; other site 360911004705 GTP/Mg2+ binding site [chemical binding]; other site 360911004706 Switch I region; other site 360911004707 G2 box; other site 360911004708 G3 box; other site 360911004709 Switch II region; other site 360911004710 G4 box; other site 360911004711 G5 box; other site 360911004712 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 360911004713 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 360911004714 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 360911004715 30S ribosomal protein S7; Validated; Region: PRK05302 360911004716 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 360911004717 S17 interaction site [polypeptide binding]; other site 360911004718 S8 interaction site; other site 360911004719 16S rRNA interaction site [nucleotide binding]; other site 360911004720 streptomycin interaction site [chemical binding]; other site 360911004721 23S rRNA interaction site [nucleotide binding]; other site 360911004722 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 360911004723 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 360911004724 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 360911004725 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 360911004726 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 360911004727 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 360911004728 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 360911004729 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 360911004730 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 360911004731 G-loop; other site 360911004732 DNA binding site [nucleotide binding] 360911004733 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 360911004734 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 360911004735 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 360911004736 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 360911004737 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 360911004738 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 360911004739 RPB10 interaction site [polypeptide binding]; other site 360911004740 RPB1 interaction site [polypeptide binding]; other site 360911004741 RPB11 interaction site [polypeptide binding]; other site 360911004742 RPB3 interaction site [polypeptide binding]; other site 360911004743 RPB12 interaction site [polypeptide binding]; other site 360911004744 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 360911004745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911004746 S-adenosylmethionine binding site [chemical binding]; other site 360911004747 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 360911004748 peripheral dimer interface [polypeptide binding]; other site 360911004749 core dimer interface [polypeptide binding]; other site 360911004750 L10 interface [polypeptide binding]; other site 360911004751 L11 interface [polypeptide binding]; other site 360911004752 putative EF-Tu interaction site [polypeptide binding]; other site 360911004753 putative EF-G interaction site [polypeptide binding]; other site 360911004754 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 360911004755 23S rRNA interface [nucleotide binding]; other site 360911004756 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 360911004757 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 360911004758 mRNA/rRNA interface [nucleotide binding]; other site 360911004759 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 360911004760 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 360911004761 23S rRNA interface [nucleotide binding]; other site 360911004762 L7/L12 interface [polypeptide binding]; other site 360911004763 putative thiostrepton binding site; other site 360911004764 L25 interface [polypeptide binding]; other site 360911004765 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 360911004766 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 360911004767 putative homodimer interface [polypeptide binding]; other site 360911004768 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 360911004769 heterodimer interface [polypeptide binding]; other site 360911004770 homodimer interface [polypeptide binding]; other site 360911004771 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 360911004772 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 360911004773 RNA polymerase factor sigma-70; Validated; Region: PRK08295 360911004774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911004775 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 360911004776 YacP-like NYN domain; Region: NYN_YacP; pfam05991 360911004777 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 360911004778 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 360911004779 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360911004780 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 360911004781 active site 360911004782 metal binding site [ion binding]; metal-binding site 360911004783 dimerization interface [polypeptide binding]; other site 360911004784 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 360911004785 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 360911004786 active site 360911004787 HIGH motif; other site 360911004788 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 360911004789 KMSKS motif; other site 360911004790 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 360911004791 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 360911004792 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 360911004793 trimer interface [polypeptide binding]; other site 360911004794 active site 360911004795 substrate binding site [chemical binding]; other site 360911004796 CoA binding site [chemical binding]; other site 360911004797 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 360911004798 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 360911004799 active site 360911004800 HIGH motif; other site 360911004801 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 360911004802 active site 360911004803 KMSKS motif; other site 360911004804 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 360911004805 homotrimer interaction site [polypeptide binding]; other site 360911004806 zinc binding site [ion binding]; other site 360911004807 CDP-binding sites; other site 360911004808 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 360911004809 substrate binding site; other site 360911004810 dimer interface; other site 360911004811 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 360911004812 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 360911004813 putative active site [active] 360911004814 DNA repair protein RadA; Provisional; Region: PRK11823 360911004815 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 360911004816 Walker A motif/ATP binding site; other site 360911004817 ATP binding site [chemical binding]; other site 360911004818 Walker B motif; other site 360911004819 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 360911004820 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 360911004821 Clp amino terminal domain; Region: Clp_N; pfam02861 360911004822 Clp amino terminal domain; Region: Clp_N; pfam02861 360911004823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004824 Walker A motif; other site 360911004825 ATP binding site [chemical binding]; other site 360911004826 Walker B motif; other site 360911004827 arginine finger; other site 360911004828 UvrB/uvrC motif; Region: UVR; pfam02151 360911004829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004830 Walker A motif; other site 360911004831 ATP binding site [chemical binding]; other site 360911004832 Walker B motif; other site 360911004833 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 360911004834 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 360911004835 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 360911004836 ADP binding site [chemical binding]; other site 360911004837 phosphagen binding site; other site 360911004838 substrate specificity loop; other site 360911004839 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 360911004840 UvrB/uvrC motif; Region: UVR; pfam02151 360911004841 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 360911004842 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 360911004843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 360911004844 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 360911004845 dimer interface [polypeptide binding]; other site 360911004846 putative anticodon binding site; other site 360911004847 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 360911004848 motif 1; other site 360911004849 active site 360911004850 motif 2; other site 360911004851 motif 3; other site 360911004852 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 360911004853 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360911004854 FMN binding site [chemical binding]; other site 360911004855 active site 360911004856 catalytic residues [active] 360911004857 substrate binding site [chemical binding]; other site 360911004858 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 360911004859 catalytic center binding site [active] 360911004860 ATP binding site [chemical binding]; other site 360911004861 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 360911004862 homooctamer interface [polypeptide binding]; other site 360911004863 active site 360911004864 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 360911004865 dihydropteroate synthase; Region: DHPS; TIGR01496 360911004866 substrate binding pocket [chemical binding]; other site 360911004867 dimer interface [polypeptide binding]; other site 360911004868 inhibitor binding site; inhibition site 360911004869 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 360911004870 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 360911004871 homodimer interface [polypeptide binding]; other site 360911004872 substrate-cofactor binding pocket; other site 360911004873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911004874 catalytic residue [active] 360911004875 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 360911004876 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 360911004877 glutamine binding [chemical binding]; other site 360911004878 catalytic triad [active] 360911004879 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 360911004880 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 360911004881 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 360911004882 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360911004883 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360911004884 dimer interface [polypeptide binding]; other site 360911004885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911004886 catalytic residue [active] 360911004887 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 360911004888 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 360911004889 dimerization interface [polypeptide binding]; other site 360911004890 domain crossover interface; other site 360911004891 redox-dependent activation switch; other site 360911004892 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360911004893 nucleotide binding site [chemical binding]; other site 360911004894 FtsH Extracellular; Region: FtsH_ext; pfam06480 360911004895 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 360911004896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911004897 Walker A motif; other site 360911004898 ATP binding site [chemical binding]; other site 360911004899 Walker B motif; other site 360911004900 arginine finger; other site 360911004901 Peptidase family M41; Region: Peptidase_M41; pfam01434 360911004902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911004903 active site 360911004904 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 360911004905 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 360911004906 Ligand Binding Site [chemical binding]; other site 360911004907 TilS substrate C-terminal domain; Region: TilS_C; smart00977 360911004908 Predicted membrane protein [Function unknown]; Region: COG1511 360911004909 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 360911004910 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 360911004911 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 360911004912 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 360911004913 RNA binding site [nucleotide binding]; other site 360911004914 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 360911004915 Septum formation initiator; Region: DivIC; pfam04977 360911004916 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911004917 RNA binding surface [nucleotide binding]; other site 360911004918 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 360911004919 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 360911004920 putative SAM binding site [chemical binding]; other site 360911004921 putative homodimer interface [polypeptide binding]; other site 360911004922 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 360911004923 homodimer interface [polypeptide binding]; other site 360911004924 metal binding site [ion binding]; metal-binding site 360911004925 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 360911004926 homodimer interface [polypeptide binding]; other site 360911004927 active site 360911004928 putative chemical substrate binding site [chemical binding]; other site 360911004929 metal binding site [ion binding]; metal-binding site 360911004930 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360911004931 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 360911004932 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 360911004933 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 360911004934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911004935 ATP binding site [chemical binding]; other site 360911004936 putative Mg++ binding site [ion binding]; other site 360911004937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911004938 nucleotide binding region [chemical binding]; other site 360911004939 ATP-binding site [chemical binding]; other site 360911004940 TRCF domain; Region: TRCF; pfam03461 360911004941 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 360911004942 putative active site [active] 360911004943 catalytic residue [active] 360911004944 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 360911004945 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 360911004946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911004947 active site 360911004948 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 360911004949 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 360911004950 Substrate binding site; other site 360911004951 Mg++ binding site; other site 360911004952 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 360911004953 active site 360911004954 substrate binding site [chemical binding]; other site 360911004955 CoA binding site [chemical binding]; other site 360911004956 regulatory protein SpoVG; Reviewed; Region: PRK13259 360911004957 pur operon repressor; Provisional; Region: PRK09213 360911004958 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 360911004959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911004960 active site 360911004961 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 360911004962 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 360911004963 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 360911004964 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 360911004965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911004966 S-adenosylmethionine binding site [chemical binding]; other site 360911004967 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 360911004968 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 360911004969 putative active site [active] 360911004970 putative metal binding site [ion binding]; other site 360911004971 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 360911004972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 360911004973 Domain of unknown function (DUF348); Region: DUF348; pfam03990 360911004974 Domain of unknown function (DUF348); Region: DUF348; pfam03990 360911004975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 360911004976 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 360911004977 active site 360911004978 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 360911004979 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 360911004980 active site 360911004981 HIGH motif; other site 360911004982 KMSKS motif; other site 360911004983 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 360911004984 tRNA binding surface [nucleotide binding]; other site 360911004985 anticodon binding site; other site 360911004986 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 360911004987 dimer interface [polypeptide binding]; other site 360911004988 putative tRNA-binding site [nucleotide binding]; other site 360911004989 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 360911004990 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 360911004991 Predicted methyltransferases [General function prediction only]; Region: COG0313 360911004992 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 360911004993 putative SAM binding site [chemical binding]; other site 360911004994 putative homodimer interface [polypeptide binding]; other site 360911004995 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 360911004996 GIY-YIG motif/motif A; other site 360911004997 putative active site [active] 360911004998 putative metal binding site [ion binding]; other site 360911004999 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 360911005000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911005001 S-adenosylmethionine binding site [chemical binding]; other site 360911005002 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 360911005003 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 360911005004 DNA polymerase III subunit delta'; Validated; Region: PRK08058 360911005005 Protein of unknown function (DUF970); Region: DUF970; pfam06153 360911005006 thymidylate kinase; Validated; Region: tmk; PRK00698 360911005007 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 360911005008 TMP-binding site; other site 360911005009 ATP-binding site [chemical binding]; other site 360911005010 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 360911005011 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911005012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911005013 catalytic residue [active] 360911005014 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 360911005015 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 360911005016 recombination protein RecR; Reviewed; Region: recR; PRK00076 360911005017 RecR protein; Region: RecR; pfam02132 360911005018 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 360911005019 putative active site [active] 360911005020 putative metal-binding site [ion binding]; other site 360911005021 tetramer interface [polypeptide binding]; other site 360911005022 hypothetical protein; Validated; Region: PRK00153 360911005023 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 360911005024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911005025 Walker A motif; other site 360911005026 ATP binding site [chemical binding]; other site 360911005027 Walker B motif; other site 360911005028 arginine finger; other site 360911005029 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 360911005030 nucleoside/Zn binding site; other site 360911005031 dimer interface [polypeptide binding]; other site 360911005032 catalytic motif [active] 360911005033 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 360911005034 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 360911005035 Substrate-binding site [chemical binding]; other site 360911005036 Substrate specificity [chemical binding]; other site 360911005037 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 360911005038 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 360911005039 Substrate-binding site [chemical binding]; other site 360911005040 Substrate specificity [chemical binding]; other site 360911005041 seryl-tRNA synthetase; Provisional; Region: PRK05431 360911005042 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 360911005043 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 360911005044 dimer interface [polypeptide binding]; other site 360911005045 active site 360911005046 motif 1; other site 360911005047 motif 2; other site 360911005048 motif 3; other site 360911005049 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 360911005050 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 360911005051 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 360911005052 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 360911005053 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 360911005054 predicted active site [active] 360911005055 catalytic triad [active] 360911005056 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 360911005057 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 360911005058 phosphate binding site [ion binding]; other site 360911005059 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 360911005060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911005061 DNA-binding site [nucleotide binding]; DNA binding site 360911005062 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911005064 homodimer interface [polypeptide binding]; other site 360911005065 catalytic residue [active] 360911005066 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 360911005067 active site 360911005068 catalytic site [active] 360911005069 Bacterial Ig-like domain; Region: Big_5; pfam13205 360911005070 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 360911005071 carbohydrate binding site [chemical binding]; other site 360911005072 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 360911005073 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 360911005074 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 360911005075 active site 360911005076 catalytic site [active] 360911005077 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 360911005078 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 360911005079 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 360911005080 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 360911005081 active site 360911005082 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 360911005083 HD domain; Region: HD_5; pfam13487 360911005084 DNA gyrase subunit A; Validated; Region: PRK05560 360911005085 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 360911005086 CAP-like domain; other site 360911005087 active site 360911005088 primary dimer interface [polypeptide binding]; other site 360911005089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911005090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911005091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911005092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911005093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360911005094 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 360911005095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005096 Mg2+ binding site [ion binding]; other site 360911005097 G-X-G motif; other site 360911005098 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 360911005099 anchoring element; other site 360911005100 dimer interface [polypeptide binding]; other site 360911005101 ATP binding site [chemical binding]; other site 360911005102 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 360911005103 active site 360911005104 putative metal-binding site [ion binding]; other site 360911005105 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 360911005106 recombination protein F; Reviewed; Region: recF; PRK00064 360911005107 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 360911005108 Walker A/P-loop; other site 360911005109 ATP binding site [chemical binding]; other site 360911005110 Q-loop/lid; other site 360911005111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911005112 ABC transporter signature motif; other site 360911005113 Walker B; other site 360911005114 D-loop; other site 360911005115 H-loop/switch region; other site 360911005116 S4 domain; Region: S4_2; pfam13275 360911005117 DNA polymerase III subunit beta; Validated; Region: PRK05643 360911005118 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 360911005119 putative DNA binding surface [nucleotide binding]; other site 360911005120 dimer interface [polypeptide binding]; other site 360911005121 beta-clamp/clamp loader binding surface; other site 360911005122 beta-clamp/translesion DNA polymerase binding surface; other site 360911005123 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 360911005124 DnaA N-terminal domain; Region: DnaA_N; pfam11638 360911005125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911005126 Walker A motif; other site 360911005127 ATP binding site [chemical binding]; other site 360911005128 Walker B motif; other site 360911005129 arginine finger; other site 360911005130 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 360911005131 DnaA box-binding interface [nucleotide binding]; other site 360911005132 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 360911005133 ribonuclease P; Reviewed; Region: rnpA; PRK00499 360911005134 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 360911005135 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 360911005136 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 360911005137 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 360911005138 active site 360911005139 NTP binding site [chemical binding]; other site 360911005140 metal binding triad [ion binding]; metal-binding site 360911005141 antibiotic binding site [chemical binding]; other site 360911005142 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 360911005143 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 360911005144 trmE is a tRNA modification GTPase; Region: trmE; cd04164 360911005145 G1 box; other site 360911005146 GTP/Mg2+ binding site [chemical binding]; other site 360911005147 Switch I region; other site 360911005148 G2 box; other site 360911005149 Switch II region; other site 360911005150 G3 box; other site 360911005151 G4 box; other site 360911005152 G5 box; other site 360911005153 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 360911005154 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 360911005155 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 360911005156 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 360911005157 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 360911005158 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 360911005159 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 360911005160 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 360911005161 ParB-like nuclease domain; Region: ParBc; pfam02195 360911005162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 360911005163 ParB-like nuclease domain; Region: ParB; smart00470 360911005164 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 360911005165 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 360911005166 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 360911005167 Mechanosensitive ion channel; Region: MS_channel; pfam00924 360911005168 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 360911005169 GTP-binding protein YchF; Reviewed; Region: PRK09601 360911005170 YchF GTPase; Region: YchF; cd01900 360911005171 G1 box; other site 360911005172 GTP/Mg2+ binding site [chemical binding]; other site 360911005173 Switch I region; other site 360911005174 G2 box; other site 360911005175 Switch II region; other site 360911005176 G3 box; other site 360911005177 G4 box; other site 360911005178 G5 box; other site 360911005179 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 360911005180 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 360911005181 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 360911005182 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 360911005183 dimer interface [polypeptide binding]; other site 360911005184 ssDNA binding site [nucleotide binding]; other site 360911005185 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360911005186 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 360911005187 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 360911005188 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 360911005189 DHH family; Region: DHH; pfam01368 360911005190 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 360911005191 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 360911005192 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 360911005193 replicative DNA helicase; Provisional; Region: PRK05748 360911005194 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 360911005195 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 360911005196 Walker A motif; other site 360911005197 ATP binding site [chemical binding]; other site 360911005198 Walker B motif; other site 360911005199 DNA binding loops [nucleotide binding] 360911005200 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 360911005201 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 360911005202 GDP-binding site [chemical binding]; other site 360911005203 ACT binding site; other site 360911005204 IMP binding site; other site 360911005205 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911005206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911005207 active site 360911005208 phosphorylation site [posttranslational modification] 360911005209 intermolecular recognition site; other site 360911005210 dimerization interface [polypeptide binding]; other site 360911005211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911005212 DNA binding site [nucleotide binding] 360911005213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 360911005214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911005215 dimerization interface [polypeptide binding]; other site 360911005216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911005217 putative active site [active] 360911005218 heme pocket [chemical binding]; other site 360911005219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911005220 dimer interface [polypeptide binding]; other site 360911005221 phosphorylation site [posttranslational modification] 360911005222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005223 ATP binding site [chemical binding]; other site 360911005224 Mg2+ binding site [ion binding]; other site 360911005225 G-X-G motif; other site 360911005226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 360911005227 YycH protein; Region: YycH; pfam07435 360911005228 YycH protein; Region: YycI; pfam09648 360911005229 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 360911005230 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 360911005231 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 360911005232 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911005233 protein binding site [polypeptide binding]; other site 360911005234 YyzF-like protein; Region: YyzF; pfam14116 360911005235 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 360911005236 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911005237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005238 Coenzyme A binding pocket [chemical binding]; other site 360911005239 Phosphopantetheine attachment site; Region: PP-binding; cl09936 360911005240 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 360911005241 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360911005242 acyl-activating enzyme (AAE) consensus motif; other site 360911005243 AMP binding site [chemical binding]; other site 360911005244 active site 360911005245 CoA binding site [chemical binding]; other site 360911005246 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 360911005247 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360911005248 methionine sulfoxide reductase A; Provisional; Region: PRK05528 360911005249 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 360911005250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911005251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911005252 DNA binding residues [nucleotide binding] 360911005253 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 360911005254 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 360911005255 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 360911005256 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 360911005257 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911005258 ATP binding site [chemical binding]; other site 360911005259 Mg++ binding site [ion binding]; other site 360911005260 motif III; other site 360911005261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911005262 nucleotide binding region [chemical binding]; other site 360911005263 ATP-binding site [chemical binding]; other site 360911005264 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 360911005265 RNA binding site [nucleotide binding]; other site 360911005266 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 360911005267 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360911005268 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 360911005269 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 360911005270 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 360911005271 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 360911005272 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 360911005273 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 360911005274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911005275 motif II; other site 360911005276 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 360911005277 Tubby C 2; Region: Tub_2; cl02043 360911005278 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 360911005279 nudix motif; other site 360911005280 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 360911005281 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 360911005282 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 360911005283 active site 360911005284 catalytic residues [active] 360911005285 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 360911005286 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 360911005287 Predicted integral membrane protein [Function unknown]; Region: COG0392 360911005288 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 360911005289 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 360911005290 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 360911005291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005293 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 360911005294 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360911005295 endonuclease III; Region: ENDO3c; smart00478 360911005296 minor groove reading motif; other site 360911005297 helix-hairpin-helix signature motif; other site 360911005298 substrate binding pocket [chemical binding]; other site 360911005299 active site 360911005300 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 360911005301 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360911005302 DNA binding site [nucleotide binding] 360911005303 active site 360911005304 EDD domain protein, DegV family; Region: DegV; TIGR00762 360911005305 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 360911005306 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360911005307 catalytic core [active] 360911005308 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 360911005309 PLD-like domain; Region: PLDc_2; pfam13091 360911005310 putative homodimer interface [polypeptide binding]; other site 360911005311 putative active site [active] 360911005312 catalytic site [active] 360911005313 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 360911005314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911005315 ATP binding site [chemical binding]; other site 360911005316 putative Mg++ binding site [ion binding]; other site 360911005317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911005318 nucleotide binding region [chemical binding]; other site 360911005319 ATP-binding site [chemical binding]; other site 360911005320 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 360911005321 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 360911005322 active site 360911005323 8-oxo-dGMP binding site [chemical binding]; other site 360911005324 nudix motif; other site 360911005325 metal binding site [ion binding]; metal-binding site 360911005326 malate:quinone oxidoreductase; Validated; Region: PRK05257 360911005327 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 360911005328 PAS fold; Region: PAS_4; pfam08448 360911005329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911005330 putative active site [active] 360911005331 heme pocket [chemical binding]; other site 360911005332 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911005333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911005334 dimer interface [polypeptide binding]; other site 360911005335 putative CheW interface [polypeptide binding]; other site 360911005336 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 360911005337 MarR family; Region: MarR_2; pfam12802 360911005338 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 360911005339 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 360911005340 NAD binding site [chemical binding]; other site 360911005341 substrate binding site [chemical binding]; other site 360911005342 catalytic Zn binding site [ion binding]; other site 360911005343 tetramer interface [polypeptide binding]; other site 360911005344 structural Zn binding site [ion binding]; other site 360911005345 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 360911005346 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911005347 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 360911005348 Walker A/P-loop; other site 360911005349 ATP binding site [chemical binding]; other site 360911005350 Q-loop/lid; other site 360911005351 ABC transporter signature motif; other site 360911005352 Walker B; other site 360911005353 D-loop; other site 360911005354 H-loop/switch region; other site 360911005355 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 360911005356 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 360911005357 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 360911005358 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 360911005359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911005360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911005361 active site 360911005362 catalytic tetrad [active] 360911005363 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911005364 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 360911005365 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 360911005366 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 360911005367 catalytic residue [active] 360911005368 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 360911005369 catalytic residues [active] 360911005370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911005371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911005372 peroxiredoxin; Region: AhpC; TIGR03137 360911005373 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 360911005374 dimer interface [polypeptide binding]; other site 360911005375 decamer (pentamer of dimers) interface [polypeptide binding]; other site 360911005376 catalytic triad [active] 360911005377 peroxidatic and resolving cysteines [active] 360911005378 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 360911005379 heat shock protein 90; Provisional; Region: PRK05218 360911005380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005381 ATP binding site [chemical binding]; other site 360911005382 Mg2+ binding site [ion binding]; other site 360911005383 G-X-G motif; other site 360911005384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911005385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911005386 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360911005387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911005388 NAD(P) binding site [chemical binding]; other site 360911005389 active site 360911005390 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 360911005391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911005392 RNA binding surface [nucleotide binding]; other site 360911005393 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 360911005394 probable active site [active] 360911005395 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 360911005396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 360911005397 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 360911005398 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 360911005399 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 360911005400 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 360911005401 PAS fold; Region: PAS_4; pfam08448 360911005402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911005403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005404 metal binding site [ion binding]; metal-binding site 360911005405 active site 360911005406 I-site; other site 360911005407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911005408 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 360911005409 GAF domain; Region: GAF; pfam01590 360911005410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911005411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005412 metal binding site [ion binding]; metal-binding site 360911005413 active site 360911005414 I-site; other site 360911005415 hypothetical protein; Provisional; Region: PRK06761 360911005416 AAA domain; Region: AAA_18; pfam13238 360911005417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 360911005418 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911005419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005420 Coenzyme A binding pocket [chemical binding]; other site 360911005421 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 360911005422 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 360911005423 active site 360911005424 PAS fold; Region: PAS_4; pfam08448 360911005425 PAS domain S-box; Region: sensory_box; TIGR00229 360911005426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911005427 putative active site [active] 360911005428 heme pocket [chemical binding]; other site 360911005429 PAS domain; Region: PAS_8; pfam13188 360911005430 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 360911005431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911005432 putative active site [active] 360911005433 heme pocket [chemical binding]; other site 360911005434 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911005435 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911005436 metal binding site [ion binding]; metal-binding site 360911005437 active site 360911005438 I-site; other site 360911005439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911005441 putative substrate translocation pore; other site 360911005442 hydroperoxidase II; Provisional; Region: katE; PRK11249 360911005443 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 360911005444 tetramer interface [polypeptide binding]; other site 360911005445 heme binding pocket [chemical binding]; other site 360911005446 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 360911005447 domain interactions; other site 360911005448 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 360911005449 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 360911005450 Fn3 associated; Region: Fn3_assoc; pfam13287 360911005451 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 360911005452 generic binding surface I; other site 360911005453 generic binding surface II; other site 360911005454 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 360911005455 putative active site [active] 360911005456 putative catalytic site [active] 360911005457 putative Mg binding site IVb [ion binding]; other site 360911005458 putative phosphate binding site [ion binding]; other site 360911005459 putative DNA binding site [nucleotide binding]; other site 360911005460 putative Mg binding site IVa [ion binding]; other site 360911005461 Esterase/lipase [General function prediction only]; Region: COG1647 360911005462 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911005463 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911005464 Ca binding site [ion binding]; other site 360911005465 active site 360911005466 catalytic site [active] 360911005467 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 360911005468 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911005469 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 360911005470 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 360911005471 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 360911005472 putative dimer interface [polypeptide binding]; other site 360911005473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911005474 ligand binding site [chemical binding]; other site 360911005475 Zn binding site [ion binding]; other site 360911005476 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 360911005477 G1 box; other site 360911005478 GTP/Mg2+ binding site [chemical binding]; other site 360911005479 G2 box; other site 360911005480 Switch I region; other site 360911005481 G3 box; other site 360911005482 Switch II region; other site 360911005483 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 360911005484 G1 box; other site 360911005485 GTP/Mg2+ binding site [chemical binding]; other site 360911005486 G2 box; other site 360911005487 Switch I region; other site 360911005488 G3 box; other site 360911005489 Switch II region; other site 360911005490 G4 box; other site 360911005491 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 360911005492 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 360911005493 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 360911005494 dimerization interface [polypeptide binding]; other site 360911005495 ligand binding site [chemical binding]; other site 360911005496 NADP binding site [chemical binding]; other site 360911005497 catalytic site [active] 360911005498 Heat induced stress protein YflT; Region: YflT; pfam11181 360911005499 Heat induced stress protein YflT; Region: YflT; pfam11181 360911005500 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 360911005501 active site 360911005502 dimer interfaces [polypeptide binding]; other site 360911005503 catalytic residues [active] 360911005504 Conserved TM helix; Region: TM_helix; pfam05552 360911005505 Conserved TM helix; Region: TM_helix; pfam05552 360911005506 Conserved TM helix; Region: TM_helix; pfam05552 360911005507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911005508 dimerization interface [polypeptide binding]; other site 360911005509 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 360911005510 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911005511 Zn2+ binding site [ion binding]; other site 360911005512 Mg2+ binding site [ion binding]; other site 360911005513 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 360911005514 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 360911005515 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 360911005516 FOG: CBS domain [General function prediction only]; Region: COG0517 360911005517 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 360911005518 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 360911005519 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 360911005520 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 360911005521 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 360911005522 dimer interface [polypeptide binding]; other site 360911005523 active site 360911005524 metal binding site [ion binding]; metal-binding site 360911005525 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 360911005526 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 360911005527 potential catalytic triad [active] 360911005528 conserved cys residue [active] 360911005529 Protein of unknown function, DUF606; Region: DUF606; pfam04657 360911005530 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 360911005531 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911005532 ligand binding site [chemical binding]; other site 360911005533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 360911005534 putative switch regulator; other site 360911005535 non-specific DNA interactions [nucleotide binding]; other site 360911005536 DNA binding site [nucleotide binding] 360911005537 sequence specific DNA binding site [nucleotide binding]; other site 360911005538 putative cAMP binding site [chemical binding]; other site 360911005539 Protein of unknown function, DUF606; Region: DUF606; pfam04657 360911005540 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360911005541 Domain of unknown function DUF21; Region: DUF21; pfam01595 360911005542 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360911005543 Transporter associated domain; Region: CorC_HlyC; smart01091 360911005544 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 360911005545 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 360911005546 metal binding site [ion binding]; metal-binding site 360911005547 dimer interface [polypeptide binding]; other site 360911005548 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911005549 nudix motif; other site 360911005550 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 360911005551 heat shock protein HtpX; Provisional; Region: PRK04897 360911005552 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 360911005553 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911005554 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911005555 active site turn [active] 360911005556 phosphorylation site [posttranslational modification] 360911005557 transcriptional antiterminator BglG; Provisional; Region: PRK09772 360911005558 CAT RNA binding domain; Region: CAT_RBD; smart01061 360911005559 PRD domain; Region: PRD; pfam00874 360911005560 PRD domain; Region: PRD; pfam00874 360911005561 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911005562 HPr interaction site; other site 360911005563 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911005564 active site 360911005565 phosphorylation site [posttranslational modification] 360911005566 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 360911005567 MutS domain III; Region: MutS_III; pfam05192 360911005568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911005569 AAA domain; Region: AAA_21; pfam13304 360911005570 Walker A/P-loop; other site 360911005571 ATP binding site [chemical binding]; other site 360911005572 Q-loop/lid; other site 360911005573 ABC transporter signature motif; other site 360911005574 Walker B; other site 360911005575 D-loop; other site 360911005576 H-loop/switch region; other site 360911005577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911005578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911005579 active site 360911005580 phosphorylation site [posttranslational modification] 360911005581 intermolecular recognition site; other site 360911005582 dimerization interface [polypeptide binding]; other site 360911005583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911005584 DNA binding site [nucleotide binding] 360911005585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911005586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911005587 dimerization interface [polypeptide binding]; other site 360911005588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911005589 dimer interface [polypeptide binding]; other site 360911005590 phosphorylation site [posttranslational modification] 360911005591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005592 ATP binding site [chemical binding]; other site 360911005593 Mg2+ binding site [ion binding]; other site 360911005594 G-X-G motif; other site 360911005595 Predicted ATPase [General function prediction only]; Region: COG3910 360911005596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911005597 Walker A/P-loop; other site 360911005598 ATP binding site [chemical binding]; other site 360911005599 Q-loop/lid; other site 360911005600 ABC transporter signature motif; other site 360911005601 Walker B; other site 360911005602 D-loop; other site 360911005603 H-loop/switch region; other site 360911005604 transcriptional antiterminator BglG; Provisional; Region: PRK09772 360911005605 CAT RNA binding domain; Region: CAT_RBD; smart01061 360911005606 PRD domain; Region: PRD; pfam00874 360911005607 PRD domain; Region: PRD; pfam00874 360911005608 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 360911005609 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911005610 active site turn [active] 360911005611 phosphorylation site [posttranslational modification] 360911005612 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911005613 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360911005614 HPr interaction site; other site 360911005615 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360911005616 active site 360911005617 phosphorylation site [posttranslational modification] 360911005618 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911005619 beta-galactosidase; Region: BGL; TIGR03356 360911005620 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 360911005621 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 360911005622 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 360911005623 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360911005624 nucleotide binding site [chemical binding]; other site 360911005625 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360911005626 active site 360911005627 P-loop; other site 360911005628 phosphorylation site [posttranslational modification] 360911005629 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 360911005630 methionine cluster; other site 360911005631 active site 360911005632 phosphorylation site [posttranslational modification] 360911005633 metal binding site [ion binding]; metal-binding site 360911005634 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911005635 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 360911005636 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 360911005637 beta-galactosidase; Region: BGL; TIGR03356 360911005638 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911005639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911005640 DNA-binding site [nucleotide binding]; DNA binding site 360911005641 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 360911005642 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911005643 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911005644 Walker A/P-loop; other site 360911005645 ATP binding site [chemical binding]; other site 360911005646 Q-loop/lid; other site 360911005647 ABC transporter signature motif; other site 360911005648 Walker B; other site 360911005649 D-loop; other site 360911005650 H-loop/switch region; other site 360911005651 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 360911005652 Methyltransferase domain; Region: Methyltransf_32; pfam13679 360911005653 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 360911005654 dimer interface [polypeptide binding]; other site 360911005655 FMN binding site [chemical binding]; other site 360911005656 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 360911005657 dimer interface [polypeptide binding]; other site 360911005658 FMN binding site [chemical binding]; other site 360911005659 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911005660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911005661 putative DNA binding site [nucleotide binding]; other site 360911005662 putative Zn2+ binding site [ion binding]; other site 360911005663 malate synthase G; Provisional; Region: PRK02999 360911005664 active site 360911005665 isocitrate lyase; Provisional; Region: PRK15063 360911005666 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 360911005667 tetramer interface [polypeptide binding]; other site 360911005668 active site 360911005669 Mg2+/Mn2+ binding site [ion binding]; other site 360911005670 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 360911005671 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 360911005672 Hemerythrin-like domain; Region: Hr-like; cd12108 360911005673 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 360911005674 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360911005675 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 360911005676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911005677 dimer interface [polypeptide binding]; other site 360911005678 conserved gate region; other site 360911005679 putative PBP binding loops; other site 360911005680 ABC-ATPase subunit interface; other site 360911005681 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 360911005682 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 360911005683 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 360911005684 [4Fe-4S] binding site [ion binding]; other site 360911005685 molybdopterin cofactor binding site; other site 360911005686 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 360911005687 molybdopterin cofactor binding site; other site 360911005688 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 360911005689 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 360911005690 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 360911005691 iron-sulfur cluster [ion binding]; other site 360911005692 [2Fe-2S] cluster binding site [ion binding]; other site 360911005693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911005694 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 360911005695 ligand binding site [chemical binding]; other site 360911005696 flexible hinge region; other site 360911005697 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 360911005698 putative switch regulator; other site 360911005699 non-specific DNA interactions [nucleotide binding]; other site 360911005700 DNA binding site [nucleotide binding] 360911005701 sequence specific DNA binding site [nucleotide binding]; other site 360911005702 putative cAMP binding site [chemical binding]; other site 360911005703 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 360911005704 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 360911005705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911005706 FeS/SAM binding site; other site 360911005707 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 360911005708 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 360911005709 MPT binding site; other site 360911005710 trimer interface [polypeptide binding]; other site 360911005711 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 360911005712 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 360911005713 GTP binding site; other site 360911005714 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 360911005715 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 360911005716 dimer interface [polypeptide binding]; other site 360911005717 putative functional site; other site 360911005718 putative MPT binding site; other site 360911005719 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 360911005720 Walker A motif; other site 360911005721 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 360911005722 MoaE homodimer interface [polypeptide binding]; other site 360911005723 MoaD interaction [polypeptide binding]; other site 360911005724 active site residues [active] 360911005725 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 360911005726 MoaE interaction surface [polypeptide binding]; other site 360911005727 MoeB interaction surface [polypeptide binding]; other site 360911005728 thiocarboxylated glycine; other site 360911005729 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 360911005730 trimer interface [polypeptide binding]; other site 360911005731 dimer interface [polypeptide binding]; other site 360911005732 putative active site [active] 360911005733 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 360911005734 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 360911005735 ATP binding site [chemical binding]; other site 360911005736 substrate interface [chemical binding]; other site 360911005737 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 360911005738 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 360911005739 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 360911005740 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 360911005741 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 360911005742 NodB motif; other site 360911005743 active site 360911005744 catalytic site [active] 360911005745 metal binding site [ion binding]; metal-binding site 360911005746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911005747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911005748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360911005749 YtkA-like; Region: YtkA; pfam13115 360911005750 YtkA-like; Region: YtkA; pfam13115 360911005751 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 360911005752 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911005753 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911005754 ABC transporter; Region: ABC_tran_2; pfam12848 360911005755 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911005756 Sugar fermentation stimulation protein; Region: SfsA; cl00647 360911005757 OsmC-like protein; Region: OsmC; cl00767 360911005758 peptidase T; Region: peptidase-T; TIGR01882 360911005759 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 360911005760 metal binding site [ion binding]; metal-binding site 360911005761 dimer interface [polypeptide binding]; other site 360911005762 LrgB-like family; Region: LrgB; pfam04172 360911005763 LrgA family; Region: LrgA; pfam03788 360911005764 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 360911005765 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 360911005766 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 360911005767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911005768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911005769 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 360911005770 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 360911005771 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 360911005772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911005773 dimer interface [polypeptide binding]; other site 360911005774 conserved gate region; other site 360911005775 putative PBP binding loops; other site 360911005776 ABC-ATPase subunit interface; other site 360911005777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911005778 dimer interface [polypeptide binding]; other site 360911005779 conserved gate region; other site 360911005780 putative PBP binding loops; other site 360911005781 ABC-ATPase subunit interface; other site 360911005782 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 360911005783 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 360911005784 Walker A/P-loop; other site 360911005785 ATP binding site [chemical binding]; other site 360911005786 Q-loop/lid; other site 360911005787 ABC transporter signature motif; other site 360911005788 Walker B; other site 360911005789 D-loop; other site 360911005790 H-loop/switch region; other site 360911005791 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 360911005792 active site 360911005793 putative catalytic site [active] 360911005794 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 360911005795 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360911005796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911005798 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 360911005799 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360911005800 Ca binding site [ion binding]; other site 360911005801 active site 360911005802 catalytic site [active] 360911005803 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 360911005804 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 360911005805 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 360911005806 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 360911005807 Pectate lyase; Region: Pec_lyase_C; cl01593 360911005808 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360911005809 DNA-binding site [nucleotide binding]; DNA binding site 360911005810 RNA-binding motif; other site 360911005811 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 360911005812 integral membrane protein; Region: integ_memb_HG; TIGR03954 360911005813 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911005815 non-specific DNA binding site [nucleotide binding]; other site 360911005816 salt bridge; other site 360911005817 sequence-specific DNA binding site [nucleotide binding]; other site 360911005818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 360911005819 26S proteasome subunit RPN7; Region: RPN7; pfam10602 360911005820 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 360911005821 putative dimer interface [polypeptide binding]; other site 360911005822 catalytic triad [active] 360911005823 Predicted transcriptional regulators [Transcription]; Region: COG1733 360911005824 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 360911005825 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 360911005826 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 360911005827 putative metal binding site [ion binding]; other site 360911005828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 360911005829 active site 360911005830 5'-3' exonuclease; Region: 53EXOc; smart00475 360911005831 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360911005832 active site 360911005833 metal binding site 1 [ion binding]; metal-binding site 360911005834 putative 5' ssDNA interaction site; other site 360911005835 metal binding site 3; metal-binding site 360911005836 metal binding site 2 [ion binding]; metal-binding site 360911005837 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360911005838 putative DNA binding site [nucleotide binding]; other site 360911005839 putative metal binding site [ion binding]; other site 360911005840 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360911005841 Domain of unknown function DUF21; Region: DUF21; pfam01595 360911005842 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360911005843 Transporter associated domain; Region: CorC_HlyC; smart01091 360911005844 glucose-1-dehydrogenase; Provisional; Region: PRK08936 360911005845 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 360911005846 NAD binding site [chemical binding]; other site 360911005847 homodimer interface [polypeptide binding]; other site 360911005848 active site 360911005849 CHASE3 domain; Region: CHASE3; cl05000 360911005850 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 360911005851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911005852 dimer interface [polypeptide binding]; other site 360911005853 phosphorylation site [posttranslational modification] 360911005854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911005855 ATP binding site [chemical binding]; other site 360911005856 Mg2+ binding site [ion binding]; other site 360911005857 G-X-G motif; other site 360911005858 Predicted transcriptional regulators [Transcription]; Region: COG1695 360911005859 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 360911005860 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 360911005861 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911005862 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360911005863 Uncharacterized conserved protein [Function unknown]; Region: COG1556 360911005864 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 360911005865 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 360911005866 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 360911005867 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 360911005868 Cysteine-rich domain; Region: CCG; pfam02754 360911005869 Cysteine-rich domain; Region: CCG; pfam02754 360911005870 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360911005871 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360911005872 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911005873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911005874 DNA binding site [nucleotide binding] 360911005875 domain linker motif; other site 360911005876 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 360911005877 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 360911005878 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 360911005879 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 360911005880 DHHA2 domain; Region: DHHA2; pfam02833 360911005881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911005882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005883 Coenzyme A binding pocket [chemical binding]; other site 360911005884 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 360911005885 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 360911005886 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 360911005887 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 360911005888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911005889 Walker A/P-loop; other site 360911005890 ATP binding site [chemical binding]; other site 360911005891 Q-loop/lid; other site 360911005892 ABC transporter signature motif; other site 360911005893 Walker B; other site 360911005894 D-loop; other site 360911005895 H-loop/switch region; other site 360911005896 Predicted membrane protein [Function unknown]; Region: COG2311 360911005897 Protein of unknown function (DUF418); Region: DUF418; pfam04235 360911005898 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911005899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911005900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911005901 ABC transporter; Region: ABC_tran_2; pfam12848 360911005902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911005903 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 360911005904 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911005905 NAD binding site [chemical binding]; other site 360911005906 putative active site [active] 360911005907 substrate binding site [chemical binding]; other site 360911005908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911005909 active site 360911005910 xanthine permease; Region: pbuX; TIGR03173 360911005911 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 360911005912 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 360911005913 NAD binding site [chemical binding]; other site 360911005914 active site 360911005915 RDD family; Region: RDD; pfam06271 360911005916 putative uracil/xanthine transporter; Provisional; Region: PRK11412 360911005917 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 360911005918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911005919 putative substrate translocation pore; other site 360911005920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005921 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 360911005922 putative catalytic site [active] 360911005923 putative metal binding site [ion binding]; other site 360911005924 putative phosphate binding site [ion binding]; other site 360911005925 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 360911005926 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360911005927 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360911005928 active site turn [active] 360911005929 phosphorylation site [posttranslational modification] 360911005930 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360911005931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911005932 Coenzyme A binding pocket [chemical binding]; other site 360911005933 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911005934 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911005935 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 360911005936 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 360911005937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911005938 FeS/SAM binding site; other site 360911005939 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 360911005940 active site 360911005941 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 360911005942 Ligand Binding Site [chemical binding]; other site 360911005943 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 360911005944 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 360911005945 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 360911005946 active site 360911005947 DNA binding site [nucleotide binding] 360911005948 intracellular protease, PfpI family; Region: PfpI; TIGR01382 360911005949 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 360911005950 proposed catalytic triad [active] 360911005951 conserved cys residue [active] 360911005952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911005953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911005954 putative substrate translocation pore; other site 360911005955 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 360911005956 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 360911005957 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 360911005958 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 360911005959 dimer interface [polypeptide binding]; other site 360911005960 substrate binding site [chemical binding]; other site 360911005961 ATP binding site [chemical binding]; other site 360911005962 FOG: CBS domain [General function prediction only]; Region: COG0517 360911005963 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 360911005964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911005965 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360911005966 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 360911005967 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 360911005968 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911005969 MarR family; Region: MarR; pfam01047 360911005970 MarR family; Region: MarR_2; cl17246 360911005971 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 360911005972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360911005973 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 360911005974 ligand binding site [chemical binding]; other site 360911005975 active site 360911005976 UGI interface [polypeptide binding]; other site 360911005977 catalytic site [active] 360911005978 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 360911005979 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 360911005980 cofactor binding site; other site 360911005981 metal binding site [ion binding]; metal-binding site 360911005982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 360911005983 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 360911005984 substrate binding pocket [chemical binding]; other site 360911005985 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911005986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911005987 active site 360911005988 motif I; other site 360911005989 motif II; other site 360911005990 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 360911005991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911005992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911005993 active site 360911005994 phosphorylation site [posttranslational modification] 360911005995 intermolecular recognition site; other site 360911005996 dimerization interface [polypeptide binding]; other site 360911005997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911005998 DNA binding site [nucleotide binding] 360911005999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911006000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006001 dimerization interface [polypeptide binding]; other site 360911006002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006003 dimer interface [polypeptide binding]; other site 360911006004 phosphorylation site [posttranslational modification] 360911006005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006006 ATP binding site [chemical binding]; other site 360911006007 Mg2+ binding site [ion binding]; other site 360911006008 G-X-G motif; other site 360911006009 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 360911006010 mercuric reductase; Validated; Region: PRK06370 360911006011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911006012 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911006013 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 360911006014 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 360911006015 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360911006016 ligand binding site [chemical binding]; other site 360911006017 flagellar motor protein MotA; Validated; Region: PRK08124 360911006018 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 360911006019 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 360911006020 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 360911006021 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 360911006022 putative NAD(P) binding site [chemical binding]; other site 360911006023 active site 360911006024 putative substrate binding site [chemical binding]; other site 360911006025 Restriction endonuclease; Region: Mrr_cat; pfam04471 360911006026 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 360911006027 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 360911006028 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 360911006029 FAD binding domain; Region: FAD_binding_4; pfam01565 360911006030 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 360911006031 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 360911006032 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 360911006033 hexamer interface [polypeptide binding]; other site 360911006034 ligand binding site [chemical binding]; other site 360911006035 putative active site [active] 360911006036 NAD(P) binding site [chemical binding]; other site 360911006037 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 360911006038 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 360911006039 Divergent PAP2 family; Region: DUF212; pfam02681 360911006040 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 360911006041 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 360911006042 active site residue [active] 360911006043 Uncharacterized conserved protein [Function unknown]; Region: COG0398 360911006044 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911006045 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 360911006046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911006047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006048 metal binding site [ion binding]; metal-binding site 360911006049 active site 360911006050 I-site; other site 360911006051 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 360911006052 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 360911006053 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 360911006054 active site 360911006055 HIGH motif; other site 360911006056 KMSK motif region; other site 360911006057 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 360911006058 tRNA binding surface [nucleotide binding]; other site 360911006059 anticodon binding site; other site 360911006060 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 360911006061 active site 360911006062 metal binding site [ion binding]; metal-binding site 360911006063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 360911006064 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 360911006065 pullulanase, type I; Region: pulA_typeI; TIGR02104 360911006066 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 360911006067 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 360911006068 Ca binding site [ion binding]; other site 360911006069 active site 360911006070 catalytic site [active] 360911006071 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 360911006072 YycC-like protein; Region: YycC; pfam14174 360911006073 MMPL family; Region: MMPL; pfam03176 360911006074 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911006075 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911006076 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911006077 YwiC-like protein; Region: YwiC; pfam14256 360911006078 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 360911006079 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 360911006080 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 360911006081 putative homodimer interface [polypeptide binding]; other site 360911006082 putative homotetramer interface [polypeptide binding]; other site 360911006083 putative metal binding site [ion binding]; other site 360911006084 putative homodimer-homodimer interface [polypeptide binding]; other site 360911006085 putative allosteric switch controlling residues; other site 360911006086 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911006087 active site residue [active] 360911006088 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 360911006089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911006090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911006091 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911006092 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 360911006093 active site residue [active] 360911006094 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 360911006095 CPxP motif; other site 360911006096 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 360911006097 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911006098 amino acid carrier protein; Region: agcS; TIGR00835 360911006099 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 360911006100 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 360911006101 intersubunit interface [polypeptide binding]; other site 360911006102 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 360911006103 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360911006104 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360911006105 catalytic core [active] 360911006106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 360911006107 YwpF-like protein; Region: YwpF; pfam14183 360911006108 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 360911006109 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 360911006110 active site 360911006111 Isochorismatase family; Region: Isochorismatase; pfam00857 360911006112 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 360911006113 catalytic triad [active] 360911006114 conserved cis-peptide bond; other site 360911006115 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 360911006116 aromatic arch; other site 360911006117 DCoH dimer interaction site [polypeptide binding]; other site 360911006118 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 360911006119 DCoH tetramer interaction site [polypeptide binding]; other site 360911006120 substrate binding site [chemical binding]; other site 360911006121 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 360911006122 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 360911006123 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 360911006124 heterotetramer interface [polypeptide binding]; other site 360911006125 active site pocket [active] 360911006126 cleavage site 360911006127 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 360911006128 nucleotide binding site [chemical binding]; other site 360911006129 N-acetyl-L-glutamate binding site [chemical binding]; other site 360911006130 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 360911006131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911006132 inhibitor-cofactor binding pocket; inhibition site 360911006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911006134 catalytic residue [active] 360911006135 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 360911006136 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 360911006137 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 360911006138 catalytic site [active] 360911006139 subunit interface [polypeptide binding]; other site 360911006140 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911006141 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 360911006142 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911006143 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 360911006144 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 360911006145 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911006146 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 360911006147 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911006148 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360911006149 ornithine carbamoyltransferase; Provisional; Region: PRK00779 360911006150 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 360911006151 Rhomboid family; Region: Rhomboid; pfam01694 360911006152 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 360911006153 alanine racemase; Reviewed; Region: alr; PRK00053 360911006154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 360911006155 active site 360911006156 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911006157 dimer interface [polypeptide binding]; other site 360911006158 substrate binding site [chemical binding]; other site 360911006159 catalytic residues [active] 360911006160 PemK-like protein; Region: PemK; pfam02452 360911006161 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 360911006162 anti sigma factor interaction site; other site 360911006163 regulatory phosphorylation site [posttranslational modification]; other site 360911006164 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 360911006165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006166 ATP binding site [chemical binding]; other site 360911006167 Mg2+ binding site [ion binding]; other site 360911006168 G-X-G motif; other site 360911006169 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 360911006170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911006171 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360911006172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911006173 DNA binding residues [nucleotide binding] 360911006174 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 360911006175 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 360911006176 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 360911006177 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 360911006178 RNA binding site [nucleotide binding]; other site 360911006179 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 360911006180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 360911006182 Coenzyme A binding pocket [chemical binding]; other site 360911006183 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360911006184 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 360911006185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360911006186 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 360911006187 active site 360911006188 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 360911006189 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 360911006190 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 360911006191 Glycoprotease family; Region: Peptidase_M22; pfam00814 360911006192 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 360911006193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006194 Coenzyme A binding pocket [chemical binding]; other site 360911006195 UGMP family protein; Validated; Region: PRK09604 360911006196 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 360911006197 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 360911006198 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 360911006199 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 360911006200 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911006201 putative NAD(P) binding site [chemical binding]; other site 360911006202 substrate binding site [chemical binding]; other site 360911006203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360911006204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360911006205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360911006206 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 360911006207 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 360911006208 dimer interface [polypeptide binding]; other site 360911006209 active site 360911006210 metal binding site [ion binding]; metal-binding site 360911006211 Uncharacterized conserved protein [Function unknown]; Region: COG1359 360911006212 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 360911006213 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 360911006214 potential catalytic triad [active] 360911006215 conserved cys residue [active] 360911006216 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911006217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911006218 Walker A/P-loop; other site 360911006219 ATP binding site [chemical binding]; other site 360911006220 Q-loop/lid; other site 360911006221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911006222 ABC transporter signature motif; other site 360911006223 Walker B; other site 360911006224 D-loop; other site 360911006225 H-loop/switch region; other site 360911006226 ABC transporter; Region: ABC_tran_2; pfam12848 360911006227 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911006228 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 360911006229 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 360911006230 CoA binding domain; Region: CoA_binding; pfam02629 360911006231 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 360911006232 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 360911006233 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 360911006234 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006235 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 360911006236 Walker A/P-loop; other site 360911006237 ATP binding site [chemical binding]; other site 360911006238 Q-loop/lid; other site 360911006239 ABC transporter signature motif; other site 360911006240 Walker B; other site 360911006241 D-loop; other site 360911006242 H-loop/switch region; other site 360911006243 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 360911006244 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006245 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 360911006246 Walker A/P-loop; other site 360911006247 ATP binding site [chemical binding]; other site 360911006248 Q-loop/lid; other site 360911006249 ABC transporter signature motif; other site 360911006250 Walker B; other site 360911006251 D-loop; other site 360911006252 H-loop/switch region; other site 360911006253 hypothetical protein; Provisional; Region: PRK13661 360911006254 Uncharacterized conserved protein [Function unknown]; Region: COG1912 360911006255 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 360911006256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911006257 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911006258 PspC domain; Region: PspC; pfam04024 360911006259 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 360911006260 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360911006261 siderophore binding site; other site 360911006262 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360911006263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911006264 ABC-ATPase subunit interface; other site 360911006265 dimer interface [polypeptide binding]; other site 360911006266 putative PBP binding regions; other site 360911006267 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360911006268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360911006269 ABC-ATPase subunit interface; other site 360911006270 dimer interface [polypeptide binding]; other site 360911006271 putative PBP binding regions; other site 360911006272 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360911006273 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360911006274 Walker A/P-loop; other site 360911006275 ATP binding site [chemical binding]; other site 360911006276 Q-loop/lid; other site 360911006277 ABC transporter signature motif; other site 360911006278 Walker B; other site 360911006279 D-loop; other site 360911006280 H-loop/switch region; other site 360911006281 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 360911006282 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 360911006283 TM2 domain; Region: TM2; pfam05154 360911006284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911006286 putative substrate translocation pore; other site 360911006287 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 360911006288 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 360911006289 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 360911006290 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 360911006291 CAAX protease self-immunity; Region: Abi; pfam02517 360911006292 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 360911006293 oligomerisation interface [polypeptide binding]; other site 360911006294 mobile loop; other site 360911006295 roof hairpin; other site 360911006296 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 360911006297 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 360911006298 ring oligomerisation interface [polypeptide binding]; other site 360911006299 ATP/Mg binding site [chemical binding]; other site 360911006300 stacking interactions; other site 360911006301 hinge regions; other site 360911006302 Competence protein CoiA-like family; Region: CoiA; cl11541 360911006303 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 360911006304 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360911006305 active site 360911006306 Part of AAA domain; Region: AAA_19; pfam13245 360911006307 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 360911006308 Uncharacterized conserved protein [Function unknown]; Region: COG3410 360911006309 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 360911006310 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 360911006311 5' RNA guide strand anchoring site; other site 360911006312 active site 360911006313 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 360911006314 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911006315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911006316 Walker A/P-loop; other site 360911006317 ATP binding site [chemical binding]; other site 360911006318 Q-loop/lid; other site 360911006319 ABC transporter signature motif; other site 360911006320 Walker B; other site 360911006321 D-loop; other site 360911006322 H-loop/switch region; other site 360911006323 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541 360911006324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911006325 ATP binding site [chemical binding]; other site 360911006326 Q-loop/lid; other site 360911006327 ABC transporter signature motif; other site 360911006328 Walker B; other site 360911006329 D-loop; other site 360911006330 H-loop/switch region; other site 360911006331 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 360911006332 LytTr DNA-binding domain; Region: LytTR; pfam04397 360911006333 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 360911006334 homodimer interface [polypeptide binding]; other site 360911006335 chemical substrate binding site [chemical binding]; other site 360911006336 oligomer interface [polypeptide binding]; other site 360911006337 metal binding site [ion binding]; metal-binding site 360911006338 Isochorismatase family; Region: Isochorismatase; pfam00857 360911006339 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 360911006340 catalytic triad [active] 360911006341 conserved cis-peptide bond; other site 360911006342 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 360911006343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911006344 putative DNA binding site [nucleotide binding]; other site 360911006345 putative Zn2+ binding site [ion binding]; other site 360911006346 AsnC family; Region: AsnC_trans_reg; pfam01037 360911006347 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 360911006348 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 360911006349 active site 360911006350 NTP binding site [chemical binding]; other site 360911006351 metal binding triad [ion binding]; metal-binding site 360911006352 FAD dependent oxidoreductase; Region: DAO; pfam01266 360911006353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911006354 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 360911006355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911006356 MarR family; Region: MarR; pfam01047 360911006357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006358 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911006359 putative substrate translocation pore; other site 360911006360 Protein of unknown function, DUF606; Region: DUF606; pfam04657 360911006361 Protein of unknown function, DUF606; Region: DUF606; pfam04657 360911006362 Protein of unknown function, DUF606; Region: DUF606; pfam04657 360911006363 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911006364 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 360911006365 ligand binding site [chemical binding]; other site 360911006366 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 360911006367 DNA binding site [nucleotide binding] 360911006368 sequence specific DNA binding site [nucleotide binding]; other site 360911006369 putative cAMP binding site [chemical binding]; other site 360911006370 Protein of unknown function, DUF606; Region: DUF606; pfam04657 360911006371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911006372 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006373 Walker A/P-loop; other site 360911006374 ATP binding site [chemical binding]; other site 360911006375 Q-loop/lid; other site 360911006376 ABC transporter signature motif; other site 360911006377 Walker B; other site 360911006378 D-loop; other site 360911006379 H-loop/switch region; other site 360911006380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911006381 phytoene desaturase; Region: crtI_fam; TIGR02734 360911006382 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 360911006383 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911006384 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360911006385 Walker A/P-loop; other site 360911006386 ATP binding site [chemical binding]; other site 360911006387 Q-loop/lid; other site 360911006388 ABC transporter signature motif; other site 360911006389 Walker B; other site 360911006390 D-loop; other site 360911006391 H-loop/switch region; other site 360911006392 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360911006393 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 360911006394 FtsX-like permease family; Region: FtsX; pfam02687 360911006395 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911006396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006397 active site 360911006398 phosphorylation site [posttranslational modification] 360911006399 intermolecular recognition site; other site 360911006400 dimerization interface [polypeptide binding]; other site 360911006401 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911006402 DNA binding site [nucleotide binding] 360911006403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911006404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006405 dimerization interface [polypeptide binding]; other site 360911006406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006407 dimer interface [polypeptide binding]; other site 360911006408 phosphorylation site [posttranslational modification] 360911006409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006410 ATP binding site [chemical binding]; other site 360911006411 Mg2+ binding site [ion binding]; other site 360911006412 G-X-G motif; other site 360911006413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911006414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911006415 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 360911006416 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360911006417 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911006418 Walker A/P-loop; other site 360911006419 ATP binding site [chemical binding]; other site 360911006420 Q-loop/lid; other site 360911006421 ABC transporter signature motif; other site 360911006422 Walker B; other site 360911006423 D-loop; other site 360911006424 H-loop/switch region; other site 360911006425 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 360911006426 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 360911006427 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911006428 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360911006429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911006430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006431 active site 360911006432 phosphorylation site [posttranslational modification] 360911006433 intermolecular recognition site; other site 360911006434 dimerization interface [polypeptide binding]; other site 360911006435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911006436 DNA binding site [nucleotide binding] 360911006437 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 360911006438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911006439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006440 dimerization interface [polypeptide binding]; other site 360911006441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006442 dimer interface [polypeptide binding]; other site 360911006443 phosphorylation site [posttranslational modification] 360911006444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006445 ATP binding site [chemical binding]; other site 360911006446 Mg2+ binding site [ion binding]; other site 360911006447 G-X-G motif; other site 360911006448 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 360911006449 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 360911006450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006451 putative substrate translocation pore; other site 360911006452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911006454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911006455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911006456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911006457 DNA binding site [nucleotide binding] 360911006458 domain linker motif; other site 360911006459 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360911006460 ligand binding site [chemical binding]; other site 360911006461 dimerization interface [polypeptide binding]; other site 360911006462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911006463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360911006464 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911006465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006466 dimer interface [polypeptide binding]; other site 360911006467 conserved gate region; other site 360911006468 putative PBP binding loops; other site 360911006469 ABC-ATPase subunit interface; other site 360911006470 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911006471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006472 dimer interface [polypeptide binding]; other site 360911006473 conserved gate region; other site 360911006474 putative PBP binding loops; other site 360911006475 ABC-ATPase subunit interface; other site 360911006476 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360911006477 beta-galactosidase; Region: BGL; TIGR03356 360911006478 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911006479 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 360911006480 NADP binding site [chemical binding]; other site 360911006481 dimer interface [polypeptide binding]; other site 360911006482 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 360911006483 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360911006484 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 360911006485 beta-galactosidase; Region: BGL; TIGR03356 360911006486 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360911006487 active site 360911006488 P-loop; other site 360911006489 phosphorylation site [posttranslational modification] 360911006490 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 360911006491 active site 360911006492 methionine cluster; other site 360911006493 phosphorylation site [posttranslational modification] 360911006494 metal binding site [ion binding]; metal-binding site 360911006495 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911006496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911006497 DNA-binding site [nucleotide binding]; DNA binding site 360911006498 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 360911006499 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 360911006500 putative catalytic site [active] 360911006501 putative metal binding site [ion binding]; other site 360911006502 putative phosphate binding site [ion binding]; other site 360911006503 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 360911006504 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 360911006505 glutaminase active site [active] 360911006506 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 360911006507 dimer interface [polypeptide binding]; other site 360911006508 active site 360911006509 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 360911006510 dimer interface [polypeptide binding]; other site 360911006511 active site 360911006512 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 360911006513 Mga helix-turn-helix domain; Region: Mga; pfam05043 360911006514 PRD domain; Region: PRD; pfam00874 360911006515 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 360911006516 active site 360911006517 P-loop; other site 360911006518 phosphorylation site [posttranslational modification] 360911006519 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 360911006520 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 360911006521 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 360911006522 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 360911006523 active site 360911006524 P-loop; other site 360911006525 phosphorylation site [posttranslational modification] 360911006526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360911006527 active site 360911006528 phosphorylation site [posttranslational modification] 360911006529 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 360911006530 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360911006531 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 360911006532 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 360911006533 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911006534 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 360911006535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911006536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006537 metal binding site [ion binding]; metal-binding site 360911006538 active site 360911006539 I-site; other site 360911006540 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006541 CAAX protease self-immunity; Region: Abi; pfam02517 360911006542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911006543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006544 Coenzyme A binding pocket [chemical binding]; other site 360911006545 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911006546 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911006547 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911006548 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911006549 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 360911006550 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 360911006551 active site 360911006552 metal binding site [ion binding]; metal-binding site 360911006553 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360911006554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911006555 non-specific DNA binding site [nucleotide binding]; other site 360911006556 salt bridge; other site 360911006557 sequence-specific DNA binding site [nucleotide binding]; other site 360911006558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911006559 TPR motif; other site 360911006560 binding surface 360911006561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 360911006562 GAF domain; Region: GAF_3; pfam13492 360911006563 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 360911006564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911006565 dimer interface [polypeptide binding]; other site 360911006566 phosphorylation site [posttranslational modification] 360911006567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911006568 ATP binding site [chemical binding]; other site 360911006569 Mg2+ binding site [ion binding]; other site 360911006570 G-X-G motif; other site 360911006571 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 360911006572 MoxR-like ATPases [General function prediction only]; Region: COG0714 360911006573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911006574 Walker A motif; other site 360911006575 ATP binding site [chemical binding]; other site 360911006576 Walker B motif; other site 360911006577 arginine finger; other site 360911006578 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 360911006579 Protein of unknown function DUF58; Region: DUF58; pfam01882 360911006580 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 360911006581 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 360911006582 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 360911006583 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 360911006584 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 360911006585 GMP synthase; Reviewed; Region: guaA; PRK00074 360911006586 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 360911006587 AMP/PPi binding site [chemical binding]; other site 360911006588 candidate oxyanion hole; other site 360911006589 catalytic triad [active] 360911006590 potential glutamine specificity residues [chemical binding]; other site 360911006591 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 360911006592 ATP Binding subdomain [chemical binding]; other site 360911006593 Ligand Binding sites [chemical binding]; other site 360911006594 Dimerization subdomain; other site 360911006595 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360911006596 VanW like protein; Region: VanW; pfam04294 360911006597 NETI protein; Region: NETI; pfam14044 360911006598 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 360911006599 nudix motif; other site 360911006600 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 360911006601 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 360911006602 ATP-grasp domain; Region: ATP-grasp; pfam02222 360911006603 adenylosuccinate lyase; Provisional; Region: PRK07492 360911006604 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 360911006605 tetramer interface [polypeptide binding]; other site 360911006606 active site 360911006607 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 360911006608 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 360911006609 ATP binding site [chemical binding]; other site 360911006610 active site 360911006611 substrate binding site [chemical binding]; other site 360911006612 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 360911006613 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 360911006614 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 360911006615 putative active site [active] 360911006616 catalytic triad [active] 360911006617 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 360911006618 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 360911006619 dimerization interface [polypeptide binding]; other site 360911006620 ATP binding site [chemical binding]; other site 360911006621 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 360911006622 dimerization interface [polypeptide binding]; other site 360911006623 ATP binding site [chemical binding]; other site 360911006624 amidophosphoribosyltransferase; Provisional; Region: PRK07631 360911006625 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 360911006626 active site 360911006627 tetramer interface [polypeptide binding]; other site 360911006628 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911006629 active site 360911006630 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 360911006631 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 360911006632 dimerization interface [polypeptide binding]; other site 360911006633 putative ATP binding site [chemical binding]; other site 360911006634 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 360911006635 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 360911006636 active site 360911006637 substrate binding site [chemical binding]; other site 360911006638 cosubstrate binding site; other site 360911006639 catalytic site [active] 360911006640 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 360911006641 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 360911006642 purine monophosphate binding site [chemical binding]; other site 360911006643 dimer interface [polypeptide binding]; other site 360911006644 putative catalytic residues [active] 360911006645 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 360911006646 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 360911006647 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 360911006648 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 360911006649 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 360911006650 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 360911006651 CHASE4 domain; Region: CHASE4; pfam05228 360911006652 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911006653 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006654 metal binding site [ion binding]; metal-binding site 360911006655 active site 360911006656 I-site; other site 360911006657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006658 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 360911006659 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911006660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911006661 active site 360911006662 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 360911006663 Trp repressor protein; Region: Trp_repressor; cl17266 360911006664 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 360911006665 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 360911006666 PcrB family; Region: PcrB; pfam01884 360911006667 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 360911006668 substrate binding site [chemical binding]; other site 360911006669 putative active site [active] 360911006670 dimer interface [polypeptide binding]; other site 360911006671 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 360911006672 Part of AAA domain; Region: AAA_19; pfam13245 360911006673 Family description; Region: UvrD_C_2; pfam13538 360911006674 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 360911006675 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 360911006676 nucleotide binding pocket [chemical binding]; other site 360911006677 K-X-D-G motif; other site 360911006678 catalytic site [active] 360911006679 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 360911006680 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 360911006681 Helix-hairpin-helix motif; Region: HHH; pfam00633 360911006682 helix-hairpin-helix signature motif; other site 360911006683 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 360911006684 Dimer interface [polypeptide binding]; other site 360911006685 BRCT sequence motif; other site 360911006686 Domain of unknown function DUF11; Region: DUF11; pfam01345 360911006687 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 360911006688 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 360911006689 putative dimer interface [polypeptide binding]; other site 360911006690 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 360911006691 putative dimer interface [polypeptide binding]; other site 360911006692 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 360911006693 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360911006694 HSP70 interaction site [polypeptide binding]; other site 360911006695 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 360911006696 substrate binding site [polypeptide binding]; other site 360911006697 dimer interface [polypeptide binding]; other site 360911006698 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 360911006699 Clp amino terminal domain; Region: Clp_N; pfam02861 360911006700 Clp amino terminal domain; Region: Clp_N; pfam02861 360911006701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911006702 Walker A motif; other site 360911006703 ATP binding site [chemical binding]; other site 360911006704 Walker B motif; other site 360911006705 arginine finger; other site 360911006706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911006707 Walker A motif; other site 360911006708 ATP binding site [chemical binding]; other site 360911006709 Walker B motif; other site 360911006710 arginine finger; other site 360911006711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 360911006712 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 360911006713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911006714 FeS/SAM binding site; other site 360911006715 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 360911006716 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 360911006717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911006718 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 360911006719 glutaminase A; Region: Gln_ase; TIGR03814 360911006720 CHAD domain; Region: CHAD; pfam05235 360911006721 multidrug efflux protein; Reviewed; Region: PRK01766 360911006722 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 360911006723 cation binding site [ion binding]; other site 360911006724 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 360911006725 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 360911006726 active site 360911006727 dimer interface [polypeptide binding]; other site 360911006728 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 360911006729 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 360911006730 active site 360911006731 trimer interface [polypeptide binding]; other site 360911006732 allosteric site; other site 360911006733 active site lid [active] 360911006734 hexamer (dimer of trimers) interface [polypeptide binding]; other site 360911006735 Transcriptional regulator [Transcription]; Region: LytR; COG1316 360911006736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911006737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911006738 DNA-binding site [nucleotide binding]; DNA binding site 360911006739 UTRA domain; Region: UTRA; pfam07702 360911006740 alanine-tRNA ligase; Region: PLN02961 360911006741 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 360911006742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 360911006743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006744 Coenzyme A binding pocket [chemical binding]; other site 360911006745 aspartate kinase; Reviewed; Region: PRK06635 360911006746 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 360911006747 putative nucleotide binding site [chemical binding]; other site 360911006748 putative catalytic residues [active] 360911006749 putative Mg ion binding site [ion binding]; other site 360911006750 putative aspartate binding site [chemical binding]; other site 360911006751 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 360911006752 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 360911006753 putative allosteric regulatory residue; other site 360911006754 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 360911006755 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 360911006756 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 360911006757 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 360911006758 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 360911006759 dimer interface [polypeptide binding]; other site 360911006760 active site 360911006761 catalytic residue [active] 360911006762 dihydrodipicolinate reductase; Provisional; Region: PRK00048 360911006763 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 360911006764 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 360911006765 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 360911006766 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 360911006767 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 360911006768 putative trimer interface [polypeptide binding]; other site 360911006769 putative CoA binding site [chemical binding]; other site 360911006770 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 360911006771 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 360911006772 homodimer interface [polypeptide binding]; other site 360911006773 substrate-cofactor binding pocket; other site 360911006774 catalytic residue [active] 360911006775 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 360911006776 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 360911006777 active site 360911006778 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911006779 dimer interface [polypeptide binding]; other site 360911006780 substrate binding site [chemical binding]; other site 360911006781 catalytic residues [active] 360911006782 diaminopimelate decarboxylase; Region: lysA; TIGR01048 360911006783 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 360911006784 active site 360911006785 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911006786 substrate binding site [chemical binding]; other site 360911006787 catalytic residues [active] 360911006788 dimer interface [polypeptide binding]; other site 360911006789 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 360911006790 putative FMN binding site [chemical binding]; other site 360911006791 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 360911006792 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 360911006793 trimer interface [polypeptide binding]; other site 360911006794 putative metal binding site [ion binding]; other site 360911006795 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 360911006796 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 360911006797 active site 360911006798 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 360911006799 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 360911006800 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911006801 peptide binding site [polypeptide binding]; other site 360911006802 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 360911006803 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 360911006804 PAS fold; Region: PAS_4; pfam08448 360911006805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911006806 putative active site [active] 360911006807 heme pocket [chemical binding]; other site 360911006808 PAS domain; Region: PAS_9; pfam13426 360911006809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911006810 putative active site [active] 360911006811 heme pocket [chemical binding]; other site 360911006812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911006813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006814 metal binding site [ion binding]; metal-binding site 360911006815 active site 360911006816 I-site; other site 360911006817 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006818 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 360911006819 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911006820 inhibitor-cofactor binding pocket; inhibition site 360911006821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911006822 catalytic residue [active] 360911006823 CrcB-like protein; Region: CRCB; cl09114 360911006824 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 360911006825 YhfH-like protein; Region: YhfH; pfam14149 360911006826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911006827 dimerization interface [polypeptide binding]; other site 360911006828 putative DNA binding site [nucleotide binding]; other site 360911006829 putative Zn2+ binding site [ion binding]; other site 360911006830 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360911006831 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 360911006832 metal-binding site [ion binding] 360911006833 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911006834 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 360911006835 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 360911006836 homodimer interface [polypeptide binding]; other site 360911006837 active site 360911006838 catalytic site [active] 360911006839 maltose binding site 2 [chemical binding]; other site 360911006840 PAS domain S-box; Region: sensory_box; TIGR00229 360911006841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360911006842 putative active site [active] 360911006843 heme pocket [chemical binding]; other site 360911006844 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911006845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911006846 metal binding site [ion binding]; metal-binding site 360911006847 active site 360911006848 I-site; other site 360911006849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360911006850 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911006851 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911006852 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911006853 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 360911006854 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 360911006855 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 360911006856 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 360911006857 Putative esterase; Region: Esterase; pfam00756 360911006858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911006859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911006860 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 360911006861 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 360911006862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911006863 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911006864 Coenzyme A binding pocket [chemical binding]; other site 360911006865 Protein of unknown function (DUF554); Region: DUF554; pfam04474 360911006866 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 360911006867 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 360911006868 Haemolytic domain; Region: Haemolytic; pfam01809 360911006869 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 360911006870 amino acid carrier protein; Region: agcS; TIGR00835 360911006871 Ion channel; Region: Ion_trans_2; pfam07885 360911006872 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 360911006873 Cytochrome P450; Region: p450; cl12078 360911006874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360911006875 NAD(P) binding site [chemical binding]; other site 360911006876 active site 360911006877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911006878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911006879 Coenzyme A binding pocket [chemical binding]; other site 360911006880 Domain of unknown function (DUF368); Region: DUF368; pfam04018 360911006881 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 360911006882 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 360911006883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911006884 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911006885 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 360911006886 dimer interface [polypeptide binding]; other site 360911006887 substrate binding site [chemical binding]; other site 360911006888 metal binding site [ion binding]; metal-binding site 360911006889 Transcriptional regulator [Transcription]; Region: LytR; COG1316 360911006890 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 360911006891 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360911006892 NAD(P) binding site [chemical binding]; other site 360911006893 putative active site [active] 360911006894 PspC domain; Region: PspC; pfam04024 360911006895 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 360911006896 active site 360911006897 catalytic residues [active] 360911006898 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360911006899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360911006900 catalytic residues [active] 360911006901 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 360911006902 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 360911006903 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911006904 Bacterial SH3 domain; Region: SH3_3; pfam08239 360911006905 Bacterial SH3 domain; Region: SH3_3; cl17532 360911006906 Bacterial SH3 domain; Region: SH3_3; cl17532 360911006907 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 360911006908 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 360911006909 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 360911006910 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360911006911 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 360911006912 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 360911006913 Potassium binding sites [ion binding]; other site 360911006914 Cesium cation binding sites [ion binding]; other site 360911006915 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360911006916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006917 dimer interface [polypeptide binding]; other site 360911006918 conserved gate region; other site 360911006919 putative PBP binding loops; other site 360911006920 ABC-ATPase subunit interface; other site 360911006921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911006922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911006923 dimer interface [polypeptide binding]; other site 360911006924 conserved gate region; other site 360911006925 putative PBP binding loops; other site 360911006926 ABC-ATPase subunit interface; other site 360911006927 asparagine synthetase AsnA; Provisional; Region: PRK05425 360911006928 motif 1; other site 360911006929 dimer interface [polypeptide binding]; other site 360911006930 active site 360911006931 motif 2; other site 360911006932 motif 3; other site 360911006933 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360911006934 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360911006935 Right handed beta helix region; Region: Beta_helix; pfam13229 360911006936 NosL; Region: NosL; cl01769 360911006937 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911006938 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911006939 Walker A/P-loop; other site 360911006940 ATP binding site [chemical binding]; other site 360911006941 Q-loop/lid; other site 360911006942 ABC transporter signature motif; other site 360911006943 Walker B; other site 360911006944 D-loop; other site 360911006945 H-loop/switch region; other site 360911006946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911006947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006948 putative substrate translocation pore; other site 360911006949 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 360911006950 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 360911006951 Peptidase family M48; Region: Peptidase_M48; cl12018 360911006952 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 360911006953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911006954 dimerization interface [polypeptide binding]; other site 360911006955 Histidine kinase; Region: His_kinase; pfam06580 360911006956 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 360911006957 Response regulator receiver domain; Region: Response_reg; pfam00072 360911006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911006959 active site 360911006960 phosphorylation site [posttranslational modification] 360911006961 intermolecular recognition site; other site 360911006962 dimerization interface [polypeptide binding]; other site 360911006963 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360911006964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911006965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360911006966 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 360911006967 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 360911006968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911006969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911006970 putative substrate translocation pore; other site 360911006971 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 360911006972 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 360911006973 NAD(P) binding site [chemical binding]; other site 360911006974 catalytic residues [active] 360911006975 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 360911006976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360911006977 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 360911006978 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 360911006979 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 360911006980 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 360911006981 Low-spin heme binding site [chemical binding]; other site 360911006982 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 360911006983 Subunit I/II interface [polypeptide binding]; other site 360911006984 Putative Q-pathway; other site 360911006985 Putative D-pathway homolog; other site 360911006986 Putative alternate electron transfer pathway; other site 360911006987 Putative water exit pathway; other site 360911006988 Binuclear center (active site) [active] 360911006989 Putative K-pathway homolog; other site 360911006990 Putative proton exit pathway; other site 360911006991 Subunit I/IIa interface [polypeptide binding]; other site 360911006992 Electron transfer pathway; other site 360911006993 uridine kinase; Provisional; Region: PRK07667 360911006994 AAA domain; Region: AAA_33; pfam13671 360911006995 active site 360911006996 Predicted transcriptional regulators [Transcription]; Region: COG1725 360911006997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911006998 DNA-binding site [nucleotide binding]; DNA binding site 360911006999 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360911007000 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911007001 Walker A/P-loop; other site 360911007002 ATP binding site [chemical binding]; other site 360911007003 Q-loop/lid; other site 360911007004 ABC transporter signature motif; other site 360911007005 Walker B; other site 360911007006 D-loop; other site 360911007007 H-loop/switch region; other site 360911007008 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911007009 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360911007010 ATP binding site [chemical binding]; other site 360911007011 Mg++ binding site [ion binding]; other site 360911007012 motif III; other site 360911007013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911007014 nucleotide binding region [chemical binding]; other site 360911007015 ATP-binding site [chemical binding]; other site 360911007016 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 360911007017 Pyruvate formate lyase 1; Region: PFL1; cd01678 360911007018 coenzyme A binding site [chemical binding]; other site 360911007019 active site 360911007020 catalytic residues [active] 360911007021 glycine loop; other site 360911007022 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 360911007023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911007024 FeS/SAM binding site; other site 360911007025 Predicted GTPases [General function prediction only]; Region: COG1162 360911007026 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911007027 RNA binding site [nucleotide binding]; other site 360911007028 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 360911007029 GTPase/Zn-binding domain interface [polypeptide binding]; other site 360911007030 GTP/Mg2+ binding site [chemical binding]; other site 360911007031 G4 box; other site 360911007032 G5 box; other site 360911007033 G1 box; other site 360911007034 Switch I region; other site 360911007035 G2 box; other site 360911007036 G3 box; other site 360911007037 Switch II region; other site 360911007038 Predicted membrane protein [Function unknown]; Region: COG4758 360911007039 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 360911007040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 360911007041 Histidine kinase; Region: HisKA_3; pfam07730 360911007042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007043 ATP binding site [chemical binding]; other site 360911007044 Mg2+ binding site [ion binding]; other site 360911007045 G-X-G motif; other site 360911007046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360911007047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911007048 active site 360911007049 phosphorylation site [posttranslational modification] 360911007050 intermolecular recognition site; other site 360911007051 dimerization interface [polypeptide binding]; other site 360911007052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360911007053 DNA binding residues [nucleotide binding] 360911007054 dimerization interface [polypeptide binding]; other site 360911007055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911007056 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911007057 Coenzyme A binding pocket [chemical binding]; other site 360911007058 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911007059 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 360911007060 putative NAD(P) binding site [chemical binding]; other site 360911007061 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911007062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911007063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911007064 ABC transporter; Region: ABC_tran_2; pfam12848 360911007065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911007066 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 360911007067 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360911007068 putative acyl-acceptor binding pocket; other site 360911007069 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 360911007070 S1 domain; Region: S1_2; pfam13509 360911007071 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360911007072 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360911007073 ATP binding site [chemical binding]; other site 360911007074 Mg++ binding site [ion binding]; other site 360911007075 motif III; other site 360911007076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911007077 nucleotide binding region [chemical binding]; other site 360911007078 ATP-binding site [chemical binding]; other site 360911007079 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 360911007080 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 360911007081 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 360911007082 active site 360911007083 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 360911007084 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 360911007085 metal binding site [ion binding]; metal-binding site 360911007086 substrate binding pocket [chemical binding]; other site 360911007087 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 360911007088 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 360911007089 acyl-activating enzyme (AAE) consensus motif; other site 360911007090 putative AMP binding site [chemical binding]; other site 360911007091 putative active site [active] 360911007092 putative CoA binding site [chemical binding]; other site 360911007093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360911007094 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 360911007095 substrate binding site [chemical binding]; other site 360911007096 oxyanion hole (OAH) forming residues; other site 360911007097 trimer interface [polypeptide binding]; other site 360911007098 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 360911007099 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 360911007100 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 360911007101 dimer interface [polypeptide binding]; other site 360911007102 tetramer interface [polypeptide binding]; other site 360911007103 PYR/PP interface [polypeptide binding]; other site 360911007104 TPP binding site [chemical binding]; other site 360911007105 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 360911007106 TPP-binding site; other site 360911007107 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 360911007108 chorismate binding enzyme; Region: Chorismate_bind; cl10555 360911007109 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 360911007110 UbiA prenyltransferase family; Region: UbiA; pfam01040 360911007111 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 360911007112 active site clefts [active] 360911007113 zinc binding site [ion binding]; other site 360911007114 dimer interface [polypeptide binding]; other site 360911007115 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 360911007116 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360911007117 nudix motif; other site 360911007118 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 360911007119 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360911007120 substrate binding site [chemical binding]; other site 360911007121 ATP binding site [chemical binding]; other site 360911007122 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 360911007123 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911007124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007125 active site 360911007126 motif I; other site 360911007127 motif II; other site 360911007128 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 360911007129 EamA-like transporter family; Region: EamA; pfam00892 360911007130 EamA-like transporter family; Region: EamA; pfam00892 360911007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911007132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911007133 putative substrate translocation pore; other site 360911007134 Radical SAM superfamily; Region: Radical_SAM; pfam04055 360911007135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911007136 FeS/SAM binding site; other site 360911007137 YfkB-like domain; Region: YfkB; pfam08756 360911007138 TRAM domain; Region: TRAM; pfam01938 360911007139 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 360911007140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911007141 S-adenosylmethionine binding site [chemical binding]; other site 360911007142 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 360911007143 active site 360911007144 catalytic motif [active] 360911007145 Zn binding site [ion binding]; other site 360911007146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911007147 dimerization interface [polypeptide binding]; other site 360911007148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911007149 dimer interface [polypeptide binding]; other site 360911007150 phosphorylation site [posttranslational modification] 360911007151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007152 ATP binding site [chemical binding]; other site 360911007153 Mg2+ binding site [ion binding]; other site 360911007154 G-X-G motif; other site 360911007155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911007156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911007157 active site 360911007158 phosphorylation site [posttranslational modification] 360911007159 intermolecular recognition site; other site 360911007160 dimerization interface [polypeptide binding]; other site 360911007161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911007162 DNA binding site [nucleotide binding] 360911007163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911007164 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911007165 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 360911007166 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 360911007167 active site 360911007168 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 360911007169 TIGR01777 family protein; Region: yfcH 360911007170 putative NAD(P) binding site [chemical binding]; other site 360911007171 putative active site [active] 360911007172 RecX family; Region: RecX; cl00936 360911007173 L-lactate permease; Region: Lactate_perm; cl00701 360911007174 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 360911007175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911007176 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 360911007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911007178 Walker A/P-loop; other site 360911007179 ATP binding site [chemical binding]; other site 360911007180 Q-loop/lid; other site 360911007181 ABC transporter signature motif; other site 360911007182 Walker B; other site 360911007183 D-loop; other site 360911007184 H-loop/switch region; other site 360911007185 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911007186 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 360911007187 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911007188 Walker A/P-loop; other site 360911007189 ATP binding site [chemical binding]; other site 360911007190 Q-loop/lid; other site 360911007191 ABC transporter signature motif; other site 360911007192 Walker B; other site 360911007193 D-loop; other site 360911007194 H-loop/switch region; other site 360911007195 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 360911007196 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 360911007197 WVELL protein; Region: WVELL; pfam14043 360911007198 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 360911007199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911007200 non-specific DNA binding site [nucleotide binding]; other site 360911007201 salt bridge; other site 360911007202 sequence-specific DNA binding site [nucleotide binding]; other site 360911007203 Cupin domain; Region: Cupin_2; pfam07883 360911007204 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360911007205 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 360911007206 Walker A/P-loop; other site 360911007207 ATP binding site [chemical binding]; other site 360911007208 Q-loop/lid; other site 360911007209 ABC transporter signature motif; other site 360911007210 Walker B; other site 360911007211 D-loop; other site 360911007212 H-loop/switch region; other site 360911007213 TOBE domain; Region: TOBE_2; pfam08402 360911007214 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 360911007215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007216 dimer interface [polypeptide binding]; other site 360911007217 conserved gate region; other site 360911007218 putative PBP binding loops; other site 360911007219 ABC-ATPase subunit interface; other site 360911007220 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360911007221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 360911007222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007223 dimer interface [polypeptide binding]; other site 360911007224 conserved gate region; other site 360911007225 putative PBP binding loops; other site 360911007226 ABC-ATPase subunit interface; other site 360911007227 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 360911007228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360911007229 Nuclease-related domain; Region: NERD; pfam08378 360911007230 Protein of unknown function (DUF779); Region: DUF779; pfam05610 360911007231 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 360911007232 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360911007233 NAD(P) binding site [chemical binding]; other site 360911007234 catalytic residues [active] 360911007235 Uncharacterized conserved protein [Function unknown]; Region: COG2353 360911007236 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 360911007237 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 360911007238 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360911007239 minor groove reading motif; other site 360911007240 helix-hairpin-helix signature motif; other site 360911007241 substrate binding pocket [chemical binding]; other site 360911007242 active site 360911007243 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 360911007244 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 360911007245 DNA binding and oxoG recognition site [nucleotide binding] 360911007246 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 360911007247 hydrophobic ligand binding site; other site 360911007248 hypothetical protein; Provisional; Region: PRK13662 360911007249 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911007250 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911007251 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 360911007252 Walker A/P-loop; other site 360911007253 ATP binding site [chemical binding]; other site 360911007254 Q-loop/lid; other site 360911007255 ABC transporter signature motif; other site 360911007256 Walker B; other site 360911007257 D-loop; other site 360911007258 H-loop/switch region; other site 360911007259 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 360911007260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360911007261 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 360911007262 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911007263 inhibitor-cofactor binding pocket; inhibition site 360911007264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911007265 catalytic residue [active] 360911007266 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360911007267 metal binding site 2 [ion binding]; metal-binding site 360911007268 putative DNA binding helix; other site 360911007269 metal binding site 1 [ion binding]; metal-binding site 360911007270 dimer interface [polypeptide binding]; other site 360911007271 structural Zn2+ binding site [ion binding]; other site 360911007272 hypothetical protein; Provisional; Region: PRK02935 360911007273 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 360911007274 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 360911007275 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 360911007276 epoxyqueuosine reductase; Region: TIGR00276 360911007277 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 360911007278 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 360911007279 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360911007280 DNA binding site [nucleotide binding] 360911007281 active site 360911007282 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 360911007283 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 360911007284 Transglycosylase; Region: Transgly; pfam00912 360911007285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 360911007286 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 360911007287 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 360911007288 ligand binding site; other site 360911007289 oligomer interface; other site 360911007290 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 360911007291 dimer interface [polypeptide binding]; other site 360911007292 N-terminal domain interface [polypeptide binding]; other site 360911007293 sulfate 1 binding site; other site 360911007294 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 360911007295 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 360911007296 ligand binding site; other site 360911007297 oligomer interface; other site 360911007298 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 360911007299 dimer interface [polypeptide binding]; other site 360911007300 N-terminal domain interface [polypeptide binding]; other site 360911007301 sulfate 1 binding site; other site 360911007302 glycogen synthase; Provisional; Region: glgA; PRK00654 360911007303 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 360911007304 ADP-binding pocket [chemical binding]; other site 360911007305 homodimer interface [polypeptide binding]; other site 360911007306 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 360911007307 homodimer interface [polypeptide binding]; other site 360911007308 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 360911007309 active site pocket [active] 360911007310 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 360911007311 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 360911007312 active site residue [active] 360911007313 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 360911007314 active site residue [active] 360911007315 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 360911007316 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 360911007317 active site 360911007318 substrate binding site [chemical binding]; other site 360911007319 metal binding site [ion binding]; metal-binding site 360911007320 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360911007321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360911007322 substrate binding pocket [chemical binding]; other site 360911007323 membrane-bound complex binding site; other site 360911007324 hinge residues; other site 360911007325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007326 dimer interface [polypeptide binding]; other site 360911007327 conserved gate region; other site 360911007328 putative PBP binding loops; other site 360911007329 ABC-ATPase subunit interface; other site 360911007330 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360911007331 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360911007332 Walker A/P-loop; other site 360911007333 ATP binding site [chemical binding]; other site 360911007334 Q-loop/lid; other site 360911007335 ABC transporter signature motif; other site 360911007336 Walker B; other site 360911007337 D-loop; other site 360911007338 H-loop/switch region; other site 360911007339 TOBE domain; Region: TOBE; pfam03459 360911007340 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 360911007341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 360911007342 hypothetical protein; Provisional; Region: PRK13676 360911007343 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 360911007344 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 360911007345 transmembrane helices; other site 360911007346 TrkA-C domain; Region: TrkA_C; pfam02080 360911007347 TrkA-C domain; Region: TrkA_C; pfam02080 360911007348 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 360911007349 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 360911007350 YhzD-like protein; Region: YhzD; pfam14120 360911007351 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 360911007352 active site 360911007353 DNA polymerase IV; Validated; Region: PRK02406 360911007354 DNA binding site [nucleotide binding] 360911007355 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 360911007356 Cl binding site [ion binding]; other site 360911007357 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 360911007358 oligomer interface [polypeptide binding]; other site 360911007359 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 360911007360 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 360911007361 generic binding surface II; other site 360911007362 generic binding surface I; other site 360911007363 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911007364 Zn2+ binding site [ion binding]; other site 360911007365 Mg2+ binding site [ion binding]; other site 360911007366 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 360911007367 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 360911007368 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 360911007369 transcriptional regulator Hpr; Provisional; Region: PRK13777 360911007370 MarR family; Region: MarR; pfam01047 360911007371 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 360911007372 HIT family signature motif; other site 360911007373 catalytic residue [active] 360911007374 Predicted membrane protein [Function unknown]; Region: COG4640 360911007375 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911007376 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360911007377 Walker A/P-loop; other site 360911007378 ATP binding site [chemical binding]; other site 360911007379 Q-loop/lid; other site 360911007380 ABC transporter signature motif; other site 360911007381 Walker B; other site 360911007382 D-loop; other site 360911007383 H-loop/switch region; other site 360911007384 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 360911007385 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 360911007386 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 360911007387 DNA binding residues [nucleotide binding] 360911007388 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911007389 putative dimer interface [polypeptide binding]; other site 360911007390 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 360911007391 substrate binding site [chemical binding]; other site 360911007392 active site 360911007393 ferrochelatase; Provisional; Region: PRK12435 360911007394 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 360911007395 C-terminal domain interface [polypeptide binding]; other site 360911007396 active site 360911007397 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 360911007398 active site 360911007399 N-terminal domain interface [polypeptide binding]; other site 360911007400 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 360911007401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911007402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007403 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911007404 active site 360911007405 motif I; other site 360911007406 motif II; other site 360911007407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007408 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 360911007409 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 360911007410 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 360911007411 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 360911007412 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 360911007413 acyl-activating enzyme (AAE) consensus motif; other site 360911007414 putative AMP binding site [chemical binding]; other site 360911007415 putative active site [active] 360911007416 putative CoA binding site [chemical binding]; other site 360911007417 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 360911007418 putative homodimer interface [polypeptide binding]; other site 360911007419 putative homotetramer interface [polypeptide binding]; other site 360911007420 putative allosteric switch controlling residues; other site 360911007421 putative metal binding site [ion binding]; other site 360911007422 putative homodimer-homodimer interface [polypeptide binding]; other site 360911007423 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 360911007424 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360911007425 metal-binding site [ion binding] 360911007426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360911007427 Soluble P-type ATPase [General function prediction only]; Region: COG4087 360911007428 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 360911007429 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360911007430 metal-binding site [ion binding] 360911007431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360911007432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911007433 active site 360911007434 phosphorylation site [posttranslational modification] 360911007435 intermolecular recognition site; other site 360911007436 dimerization interface [polypeptide binding]; other site 360911007437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360911007438 DNA binding site [nucleotide binding] 360911007439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360911007440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911007441 dimerization interface [polypeptide binding]; other site 360911007442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911007443 dimer interface [polypeptide binding]; other site 360911007444 phosphorylation site [posttranslational modification] 360911007445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007446 ATP binding site [chemical binding]; other site 360911007447 Mg2+ binding site [ion binding]; other site 360911007448 G-X-G motif; other site 360911007449 ComK protein; Region: ComK; cl11560 360911007450 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 360911007451 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 360911007452 apolar tunnel; other site 360911007453 heme binding site [chemical binding]; other site 360911007454 dimerization interface [polypeptide binding]; other site 360911007455 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 360911007456 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 360911007457 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 360911007458 Part of AAA domain; Region: AAA_19; pfam13245 360911007459 Family description; Region: UvrD_C_2; pfam13538 360911007460 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 360911007461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911007462 MarR family; Region: MarR; pfam01047 360911007463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911007464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911007465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911007466 Walker A/P-loop; other site 360911007467 ATP binding site [chemical binding]; other site 360911007468 Q-loop/lid; other site 360911007469 ABC transporter signature motif; other site 360911007470 Walker B; other site 360911007471 D-loop; other site 360911007472 H-loop/switch region; other site 360911007473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911007474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911007475 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 360911007476 Walker A/P-loop; other site 360911007477 ATP binding site [chemical binding]; other site 360911007478 Q-loop/lid; other site 360911007479 ABC transporter signature motif; other site 360911007480 Walker B; other site 360911007481 D-loop; other site 360911007482 H-loop/switch region; other site 360911007483 Response regulator receiver domain; Region: Response_reg; pfam00072 360911007484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911007485 active site 360911007486 phosphorylation site [posttranslational modification] 360911007487 intermolecular recognition site; other site 360911007488 dimerization interface [polypeptide binding]; other site 360911007489 HAMP domain; Region: HAMP; pfam00672 360911007490 GAF domain; Region: GAF_3; pfam13492 360911007491 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 360911007492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360911007493 dimer interface [polypeptide binding]; other site 360911007494 phosphorylation site [posttranslational modification] 360911007495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007496 ATP binding site [chemical binding]; other site 360911007497 Mg2+ binding site [ion binding]; other site 360911007498 G-X-G motif; other site 360911007499 hypothetical protein; Provisional; Region: PRK13673 360911007500 Methyltransferase domain; Region: Methyltransf_31; pfam13847 360911007501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911007502 S-adenosylmethionine binding site [chemical binding]; other site 360911007503 phytoene desaturase; Region: crtI_fam; TIGR02734 360911007504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911007505 hydroxyglutarate oxidase; Provisional; Region: PRK11728 360911007506 phytoene desaturase; Region: crtI_fam; TIGR02734 360911007507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911007508 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 360911007509 active site lid residues [active] 360911007510 substrate binding pocket [chemical binding]; other site 360911007511 catalytic residues [active] 360911007512 substrate-Mg2+ binding site; other site 360911007513 aspartate-rich region 1; other site 360911007514 aspartate-rich region 2; other site 360911007515 phytoene desaturase; Region: crtI_fam; TIGR02734 360911007516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911007517 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 360911007518 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 360911007519 active site 360911007520 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 360911007521 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 360911007522 putative acyl-acceptor binding pocket; other site 360911007523 Protein of unknown function (DUF422); Region: DUF422; cl00991 360911007524 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 360911007525 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 360911007526 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 360911007527 putative deacylase active site [active] 360911007528 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 360911007529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360911007530 substrate binding site [chemical binding]; other site 360911007531 oxyanion hole (OAH) forming residues; other site 360911007532 trimer interface [polypeptide binding]; other site 360911007533 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 360911007534 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 360911007535 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 360911007536 homodimer interface [polypeptide binding]; other site 360911007537 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 360911007538 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 360911007539 active site 360911007540 homodimer interface [polypeptide binding]; other site 360911007541 catalytic site [active] 360911007542 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 360911007543 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360911007544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007545 dimer interface [polypeptide binding]; other site 360911007546 conserved gate region; other site 360911007547 ABC-ATPase subunit interface; other site 360911007548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360911007549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911007550 dimer interface [polypeptide binding]; other site 360911007551 conserved gate region; other site 360911007552 putative PBP binding loops; other site 360911007553 ABC-ATPase subunit interface; other site 360911007554 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 360911007555 trehalose synthase; Region: treS_nterm; TIGR02456 360911007556 active site 360911007557 catalytic site [active] 360911007558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360911007559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360911007560 DNA binding site [nucleotide binding] 360911007561 domain linker motif; other site 360911007562 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 360911007563 putative dimerization interface [polypeptide binding]; other site 360911007564 putative ligand binding site [chemical binding]; other site 360911007565 Heat induced stress protein YflT; Region: YflT; pfam11181 360911007566 maltose phosphorylase; Provisional; Region: PRK13807 360911007567 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 360911007568 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 360911007569 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 360911007570 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911007571 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911007572 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911007573 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911007574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007575 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 360911007576 active site 360911007577 motif I; other site 360911007578 motif II; other site 360911007579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007580 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 360911007581 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911007582 catalytic residues [active] 360911007583 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 360911007584 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 360911007585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911007586 active site 360911007587 motif I; other site 360911007588 motif II; other site 360911007589 GTPase YqeH; Provisional; Region: PRK13796 360911007590 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 360911007591 GTP/Mg2+ binding site [chemical binding]; other site 360911007592 G4 box; other site 360911007593 G5 box; other site 360911007594 G1 box; other site 360911007595 Switch I region; other site 360911007596 G2 box; other site 360911007597 G3 box; other site 360911007598 Switch II region; other site 360911007599 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 360911007600 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 360911007601 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 360911007602 shikimate binding site; other site 360911007603 NAD(P) binding site [chemical binding]; other site 360911007604 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 360911007605 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 360911007606 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 360911007607 active site 360911007608 (T/H)XGH motif; other site 360911007609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911007610 Zn2+ binding site [ion binding]; other site 360911007611 Mg2+ binding site [ion binding]; other site 360911007612 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 360911007613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911007614 S-adenosylmethionine binding site [chemical binding]; other site 360911007615 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 360911007616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911007617 dimer interface [polypeptide binding]; other site 360911007618 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 360911007619 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 360911007620 tetramer interface [polypeptide binding]; other site 360911007621 heme binding pocket [chemical binding]; other site 360911007622 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 360911007623 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 360911007624 dimer interface [polypeptide binding]; other site 360911007625 FMN binding site [chemical binding]; other site 360911007626 NADPH bind site [chemical binding]; other site 360911007627 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360911007628 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360911007629 catalytic residues [active] 360911007630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 360911007631 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007633 active site residue [active] 360911007634 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007635 active site residue [active] 360911007636 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360911007637 active site residue [active] 360911007638 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 360911007639 Isochorismatase family; Region: Isochorismatase; pfam00857 360911007640 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 360911007641 catalytic triad [active] 360911007642 conserved cis-peptide bond; other site 360911007643 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 360911007644 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 360911007645 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911007646 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 360911007647 Walker A/P-loop; other site 360911007648 ATP binding site [chemical binding]; other site 360911007649 Q-loop/lid; other site 360911007650 ABC transporter signature motif; other site 360911007651 Walker B; other site 360911007652 D-loop; other site 360911007653 H-loop/switch region; other site 360911007654 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 360911007655 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 360911007656 TPP-binding site [chemical binding]; other site 360911007657 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 360911007658 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 360911007659 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360911007660 E3 interaction surface; other site 360911007661 lipoyl attachment site [posttranslational modification]; other site 360911007662 e3 binding domain; Region: E3_binding; pfam02817 360911007663 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 360911007664 HAMP domain; Region: HAMP; pfam00672 360911007665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360911007666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360911007667 metal binding site [ion binding]; metal-binding site 360911007668 active site 360911007669 I-site; other site 360911007670 Thioredoxin; Region: Thioredoxin_4; pfam13462 360911007671 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 360911007672 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 360911007673 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 360911007674 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 360911007675 Cu(I) binding site [ion binding]; other site 360911007676 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 360911007677 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 360911007678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911007679 H+ Antiporter protein; Region: 2A0121; TIGR00900 360911007680 putative substrate translocation pore; other site 360911007681 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 360911007682 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 360911007683 catalytic residues [active] 360911007684 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 360911007685 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 360911007686 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 360911007687 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 360911007688 pentamer interface [polypeptide binding]; other site 360911007689 dodecaamer interface [polypeptide binding]; other site 360911007690 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 360911007691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360911007692 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360911007693 active site 360911007694 catalytic tetrad [active] 360911007695 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 360911007696 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 360911007697 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360911007698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911007699 ABC transporter; Region: ABC_tran_2; pfam12848 360911007700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360911007701 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 360911007702 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 360911007703 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 360911007704 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911007705 putative active site [active] 360911007706 putative metal binding site [ion binding]; other site 360911007707 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 360911007708 Transcriptional regulators [Transcription]; Region: MarR; COG1846 360911007709 MarR family; Region: MarR; pfam01047 360911007710 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 360911007711 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 360911007712 Uncharacterized conserved protein [Function unknown]; Region: COG3391 360911007713 NHL repeat; Region: NHL; pfam01436 360911007714 NHL repeat; Region: NHL; pfam01436 360911007715 NHL repeat; Region: NHL; pfam01436 360911007716 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 360911007717 catalytic residues [active] 360911007718 dimer interface [polypeptide binding]; other site 360911007719 Predicted integral membrane protein [Function unknown]; Region: COG5652 360911007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 360911007721 Arabidopsis phospholipase-like protein (PEARLI 4); Region: PEARLI-4; pfam05278 360911007722 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 360911007723 Peptidase family M23; Region: Peptidase_M23; pfam01551 360911007724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911007725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 360911007726 Coenzyme A binding pocket [chemical binding]; other site 360911007727 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 360911007728 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 360911007729 Cell division protein ZapA; Region: ZapA; cl01146 360911007730 Colicin V production protein; Region: Colicin_V; pfam02674 360911007731 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 360911007732 hypothetical protein; Provisional; Region: PRK08609 360911007733 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 360911007734 active site 360911007735 primer binding site [nucleotide binding]; other site 360911007736 NTP binding site [chemical binding]; other site 360911007737 metal binding triad [ion binding]; metal-binding site 360911007738 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 360911007739 active site 360911007740 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 360911007741 MutS domain III; Region: MutS_III; pfam05192 360911007742 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 360911007743 Walker A/P-loop; other site 360911007744 ATP binding site [chemical binding]; other site 360911007745 Q-loop/lid; other site 360911007746 ABC transporter signature motif; other site 360911007747 Walker B; other site 360911007748 D-loop; other site 360911007749 H-loop/switch region; other site 360911007750 Smr domain; Region: Smr; pfam01713 360911007751 Predicted membrane protein [Function unknown]; Region: COG3766 360911007752 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 360911007753 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 360911007754 AAA domain; Region: AAA_13; pfam13166 360911007755 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360911007756 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 360911007757 FtsX-like permease family; Region: FtsX; pfam02687 360911007758 FtsX-like permease family; Region: FtsX; pfam02687 360911007759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360911007760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360911007761 Walker A/P-loop; other site 360911007762 ATP binding site [chemical binding]; other site 360911007763 Q-loop/lid; other site 360911007764 ABC transporter signature motif; other site 360911007765 Walker B; other site 360911007766 D-loop; other site 360911007767 H-loop/switch region; other site 360911007768 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 360911007769 metal binding site [ion binding]; metal-binding site 360911007770 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 360911007771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911007772 AAA domain; Region: AAA_23; pfam13476 360911007773 Walker A/P-loop; other site 360911007774 ATP binding site [chemical binding]; other site 360911007775 Q-loop/lid; other site 360911007776 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 360911007777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 360911007778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 360911007779 putative Mg++ binding site [ion binding]; other site 360911007780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911007781 nucleotide binding region [chemical binding]; other site 360911007782 ATP-binding site [chemical binding]; other site 360911007783 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 360911007784 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 360911007785 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 360911007786 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 360911007787 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 360911007788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911007789 catalytic residue [active] 360911007790 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 360911007791 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 360911007792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911007793 Walker A/P-loop; other site 360911007794 ATP binding site [chemical binding]; other site 360911007795 hypothetical protein; Provisional; Region: PRK06850 360911007796 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 360911007797 Active Sites [active] 360911007798 DNA-sulfur modification-associated; Region: DndB; cl17621 360911007799 DGQHR domain; Region: DGQHR; TIGR03187 360911007800 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 360911007801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911007802 Walker A/P-loop; other site 360911007803 ATP binding site [chemical binding]; other site 360911007804 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 360911007805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911007806 ATP binding site [chemical binding]; other site 360911007807 Mg2+ binding site [ion binding]; other site 360911007808 G-X-G motif; other site 360911007809 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 360911007810 Uncharacterized conserved protein [Function unknown]; Region: COG1359 360911007811 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 360911007812 dimer interface [polypeptide binding]; other site 360911007813 FMN binding site [chemical binding]; other site 360911007814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360911007815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911007816 putative DNA binding site [nucleotide binding]; other site 360911007817 putative Zn2+ binding site [ion binding]; other site 360911007818 Predicted transcriptional regulators [Transcription]; Region: COG1725 360911007819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911007820 DNA-binding site [nucleotide binding]; DNA binding site 360911007821 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360911007822 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360911007823 Walker A/P-loop; other site 360911007824 ATP binding site [chemical binding]; other site 360911007825 Q-loop/lid; other site 360911007826 ABC transporter signature motif; other site 360911007827 Walker B; other site 360911007828 D-loop; other site 360911007829 H-loop/switch region; other site 360911007830 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 360911007831 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 360911007832 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 360911007833 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 360911007834 acyl-activating enzyme (AAE) consensus motif; other site 360911007835 putative AMP binding site [chemical binding]; other site 360911007836 putative active site [active] 360911007837 putative CoA binding site [chemical binding]; other site 360911007838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360911007839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360911007840 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 360911007841 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 360911007842 Ligand binding site [chemical binding]; other site 360911007843 Electron transfer flavoprotein domain; Region: ETF; pfam01012 360911007844 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 360911007845 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 360911007846 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 360911007847 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360911007848 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360911007849 catalytic residues [active] 360911007850 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 360911007851 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 360911007852 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 360911007853 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 360911007854 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 360911007855 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 360911007856 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 360911007857 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 360911007858 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 360911007859 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 360911007860 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 360911007861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911007862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911007863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911007864 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 360911007865 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 360911007866 GIY-YIG motif/motif A; other site 360911007867 active site 360911007868 catalytic site [active] 360911007869 putative DNA binding site [nucleotide binding]; other site 360911007870 metal binding site [ion binding]; metal-binding site 360911007871 UvrB/uvrC motif; Region: UVR; pfam02151 360911007872 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 360911007873 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 360911007874 DNA binding site [nucleotide binding] 360911007875 aminoglycoside resistance protein; Provisional; Region: PRK13746 360911007876 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 360911007877 active site 360911007878 NTP binding site [chemical binding]; other site 360911007879 metal binding triad [ion binding]; metal-binding site 360911007880 antibiotic binding site [chemical binding]; other site 360911007881 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 360911007882 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 360911007883 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 360911007884 putative Iron-sulfur protein interface [polypeptide binding]; other site 360911007885 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 360911007886 proximal heme binding site [chemical binding]; other site 360911007887 distal heme binding site [chemical binding]; other site 360911007888 putative dimer interface [polypeptide binding]; other site 360911007889 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 360911007890 L-aspartate oxidase; Provisional; Region: PRK06175 360911007891 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 360911007892 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 360911007893 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 360911007894 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360911007895 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 360911007896 active site 360911007897 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 360911007898 dimerization domain swap beta strand [polypeptide binding]; other site 360911007899 regulatory protein interface [polypeptide binding]; other site 360911007900 active site 360911007901 regulatory phosphorylation site [posttranslational modification]; other site 360911007902 glutamate racemase; Provisional; Region: PRK00865 360911007903 ribonuclease PH; Reviewed; Region: rph; PRK00173 360911007904 Ribonuclease PH; Region: RNase_PH_bact; cd11362 360911007905 hexamer interface [polypeptide binding]; other site 360911007906 active site 360911007907 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 360911007908 active site 360911007909 dimerization interface [polypeptide binding]; other site 360911007910 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 360911007911 active site 360911007912 metal binding site [ion binding]; metal-binding site 360911007913 homotetramer interface [polypeptide binding]; other site 360911007914 trigger factor; Provisional; Region: tig; PRK01490 360911007915 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 360911007916 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 360911007917 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 360911007918 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 360911007919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911007920 Walker A motif; other site 360911007921 ATP binding site [chemical binding]; other site 360911007922 Walker B motif; other site 360911007923 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360911007924 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 360911007925 Found in ATP-dependent protease La (LON); Region: LON; smart00464 360911007926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911007927 Walker A motif; other site 360911007928 ATP binding site [chemical binding]; other site 360911007929 Walker B motif; other site 360911007930 arginine finger; other site 360911007931 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 360911007932 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 360911007933 G1 box; other site 360911007934 GTP/Mg2+ binding site [chemical binding]; other site 360911007935 Switch I region; other site 360911007936 G2 box; other site 360911007937 G3 box; other site 360911007938 Switch II region; other site 360911007939 G4 box; other site 360911007940 G5 box; other site 360911007941 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 360911007942 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360911007943 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 360911007944 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 360911007945 tRNA; other site 360911007946 putative tRNA binding site [nucleotide binding]; other site 360911007947 putative NADP binding site [chemical binding]; other site 360911007948 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 360911007949 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 360911007950 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 360911007951 domain interfaces; other site 360911007952 active site 360911007953 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 360911007954 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 360911007955 active site 360911007956 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 360911007957 dimer interface [polypeptide binding]; other site 360911007958 active site 360911007959 Schiff base residues; other site 360911007960 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 360911007961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360911007962 inhibitor-cofactor binding pocket; inhibition site 360911007963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911007964 catalytic residue [active] 360911007965 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 360911007966 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911007967 active site 360911007968 HIGH motif; other site 360911007969 nucleotide binding site [chemical binding]; other site 360911007970 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360911007971 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 360911007972 active site 360911007973 KMSKS motif; other site 360911007974 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 360911007975 tRNA binding surface [nucleotide binding]; other site 360911007976 anticodon binding site; other site 360911007977 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 360911007978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360911007979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911007980 Coenzyme A binding pocket [chemical binding]; other site 360911007981 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 360911007982 hypothetical protein; Validated; Region: PRK00029 360911007983 Uncharacterized conserved protein [Function unknown]; Region: COG0397 360911007984 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 360911007985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911007986 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 360911007987 VanW like protein; Region: VanW; pfam04294 360911007988 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 360911007989 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 360911007990 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 360911007991 Walker A motif; other site 360911007992 ATP binding site [chemical binding]; other site 360911007993 Walker B motif; other site 360911007994 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 360911007995 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360911007996 Walker A motif; other site 360911007997 ATP binding site [chemical binding]; other site 360911007998 Walker B motif; other site 360911007999 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 360911008000 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360911008001 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360911008002 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 360911008003 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 360911008004 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 360911008005 Competence protein A; Region: Competence_A; pfam11104 360911008006 Maf-like protein; Region: Maf; pfam02545 360911008007 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 360911008008 active site 360911008009 dimer interface [polypeptide binding]; other site 360911008010 DNA repair protein radc; Region: radc; TIGR00608 360911008011 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 360911008012 MPN+ (JAMM) motif; other site 360911008013 Zinc-binding site [ion binding]; other site 360911008014 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 360911008015 rod shape-determining protein MreB; Provisional; Region: PRK13927 360911008016 MreB and similar proteins; Region: MreB_like; cd10225 360911008017 nucleotide binding site [chemical binding]; other site 360911008018 Mg binding site [ion binding]; other site 360911008019 putative protofilament interaction site [polypeptide binding]; other site 360911008020 RodZ interaction site [polypeptide binding]; other site 360911008021 rod shape-determining protein MreC; Provisional; Region: PRK13922 360911008022 rod shape-determining protein MreC; Region: MreC; pfam04085 360911008023 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 360911008024 septum formation inhibitor; Reviewed; Region: minC; PRK00513 360911008025 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 360911008026 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 360911008027 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 360911008028 Switch I; other site 360911008029 Switch II; other site 360911008030 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 360911008031 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911008032 RNA binding site [nucleotide binding]; other site 360911008033 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 360911008034 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 360911008035 Protein of unknown function (DUF464); Region: DUF464; pfam04327 360911008036 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 360911008037 GTPase CgtA; Reviewed; Region: obgE; PRK12297 360911008038 GTP1/OBG; Region: GTP1_OBG; pfam01018 360911008039 Obg GTPase; Region: Obg; cd01898 360911008040 G1 box; other site 360911008041 GTP/Mg2+ binding site [chemical binding]; other site 360911008042 Switch I region; other site 360911008043 G2 box; other site 360911008044 G3 box; other site 360911008045 Switch II region; other site 360911008046 G4 box; other site 360911008047 G5 box; other site 360911008048 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 360911008049 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360911008050 Domain of unknown function DUF21; Region: DUF21; pfam01595 360911008051 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360911008052 Transporter associated domain; Region: CorC_HlyC; smart01091 360911008053 NIPSNAP; Region: NIPSNAP; pfam07978 360911008054 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 360911008055 nudix motif; other site 360911008056 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360911008057 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360911008058 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 360911008059 HTH domain; Region: HTH_11; pfam08279 360911008060 3H domain; Region: 3H; pfam02829 360911008061 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911008062 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 360911008063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911008064 catalytic residue [active] 360911008065 L-aspartate oxidase; Provisional; Region: PRK06175 360911008066 L-aspartate oxidase; Region: nadB; TIGR00551 360911008067 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 360911008068 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 360911008069 dimerization interface [polypeptide binding]; other site 360911008070 active site 360911008071 quinolinate synthetase; Provisional; Region: PRK09375 360911008072 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 360911008073 RuvA N terminal domain; Region: RuvA_N; pfam01330 360911008074 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 360911008075 DNA binding site [nucleotide binding] 360911008076 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 360911008077 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 360911008078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911008079 Walker A motif; other site 360911008080 ATP binding site [chemical binding]; other site 360911008081 Walker B motif; other site 360911008082 arginine finger; other site 360911008083 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 360911008084 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 360911008085 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 360911008086 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 360911008087 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 360911008088 Preprotein translocase subunit; Region: YajC; pfam02699 360911008089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 360911008090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360911008091 CHASE3 domain; Region: CHASE3; cl05000 360911008092 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 360911008093 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 360911008094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360911008095 dimerization interface [polypeptide binding]; other site 360911008096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360911008097 dimer interface [polypeptide binding]; other site 360911008098 putative CheW interface [polypeptide binding]; other site 360911008099 zinc transporter ZupT; Provisional; Region: PRK04201 360911008100 ZIP Zinc transporter; Region: Zip; pfam02535 360911008101 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 360911008102 DHH family; Region: DHH; pfam01368 360911008103 DHHA1 domain; Region: DHHA1; pfam02272 360911008104 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 360911008105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911008106 active site 360911008107 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 360911008108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360911008109 Zn2+ binding site [ion binding]; other site 360911008110 Mg2+ binding site [ion binding]; other site 360911008111 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911008112 synthetase active site [active] 360911008113 NTP binding site [chemical binding]; other site 360911008114 metal binding site [ion binding]; metal-binding site 360911008115 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 360911008116 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 360911008117 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 360911008118 putative active site [active] 360911008119 dimerization interface [polypeptide binding]; other site 360911008120 putative tRNAtyr binding site [nucleotide binding]; other site 360911008121 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 360911008122 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 360911008123 dimer interface [polypeptide binding]; other site 360911008124 motif 1; other site 360911008125 active site 360911008126 motif 2; other site 360911008127 motif 3; other site 360911008128 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 360911008129 anticodon binding site; other site 360911008130 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 360911008131 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 360911008132 dimer interface [polypeptide binding]; other site 360911008133 anticodon binding site; other site 360911008134 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 360911008135 homodimer interface [polypeptide binding]; other site 360911008136 motif 1; other site 360911008137 active site 360911008138 motif 2; other site 360911008139 GAD domain; Region: GAD; pfam02938 360911008140 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 360911008141 motif 3; other site 360911008142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 360911008143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360911008144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360911008145 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 360911008146 Walker A/P-loop; other site 360911008147 ATP binding site [chemical binding]; other site 360911008148 Q-loop/lid; other site 360911008149 ABC transporter signature motif; other site 360911008150 Walker B; other site 360911008151 D-loop; other site 360911008152 H-loop/switch region; other site 360911008153 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 360911008154 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 360911008155 putative NAD(P) binding site [chemical binding]; other site 360911008156 Predicted membrane protein [Function unknown]; Region: COG2364 360911008157 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911008158 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 360911008159 DNA photolyase; Region: DNA_photolyase; pfam00875 360911008160 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 360911008161 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 360911008162 putative ATP binding site [chemical binding]; other site 360911008163 putative substrate interface [chemical binding]; other site 360911008164 recombination factor protein RarA; Reviewed; Region: PRK13342 360911008165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911008166 Walker A motif; other site 360911008167 ATP binding site [chemical binding]; other site 360911008168 Walker B motif; other site 360911008169 arginine finger; other site 360911008170 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 360911008171 Rrf2 family protein; Region: rrf2_super; TIGR00738 360911008172 Transcriptional regulator; Region: Rrf2; pfam02082 360911008173 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 360911008174 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 360911008175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911008176 catalytic residue [active] 360911008177 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 360911008178 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 360911008179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911008180 binding surface 360911008181 Tetratricopeptide repeat; Region: TPR_16; pfam13432 360911008182 TPR motif; other site 360911008183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911008184 binding surface 360911008185 TPR motif; other site 360911008186 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 360911008187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360911008188 active site 360911008189 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 360911008190 AAA domain; Region: AAA_30; pfam13604 360911008191 Family description; Region: UvrD_C_2; pfam13538 360911008192 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 360911008193 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 360911008194 motif 1; other site 360911008195 active site 360911008196 motif 2; other site 360911008197 motif 3; other site 360911008198 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 360911008199 DHHA1 domain; Region: DHHA1; pfam02272 360911008200 hypothetical protein; Provisional; Region: PRK05473 360911008201 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 360911008202 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 360911008203 YceG-like family; Region: YceG; pfam02618 360911008204 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 360911008205 dimerization interface [polypeptide binding]; other site 360911008206 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 360911008207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911008208 S-adenosylmethionine binding site [chemical binding]; other site 360911008209 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 360911008210 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 360911008211 ATP-binding site [chemical binding]; other site 360911008212 Sugar specificity; other site 360911008213 Pyrimidine base specificity; other site 360911008214 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 360911008215 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 360911008216 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360911008217 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 360911008218 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 360911008219 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 360911008220 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 360911008221 dimer interface [polypeptide binding]; other site 360911008222 active site 360911008223 CoA binding pocket [chemical binding]; other site 360911008224 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 360911008225 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 360911008226 dimer interface [polypeptide binding]; other site 360911008227 active site 360911008228 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360911008229 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911008230 peptide binding site [polypeptide binding]; other site 360911008231 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360911008232 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911008233 peptide binding site [polypeptide binding]; other site 360911008234 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 360911008235 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 360911008236 active site 360911008237 HIGH motif; other site 360911008238 dimer interface [polypeptide binding]; other site 360911008239 KMSKS motif; other site 360911008240 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 360911008241 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360911008242 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360911008243 peptide binding site [polypeptide binding]; other site 360911008244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360911008245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911008246 dimer interface [polypeptide binding]; other site 360911008247 conserved gate region; other site 360911008248 putative PBP binding loops; other site 360911008249 ABC-ATPase subunit interface; other site 360911008250 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 360911008251 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 360911008252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360911008253 dimer interface [polypeptide binding]; other site 360911008254 conserved gate region; other site 360911008255 putative PBP binding loops; other site 360911008256 ABC-ATPase subunit interface; other site 360911008257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 360911008258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360911008259 Walker A/P-loop; other site 360911008260 ATP binding site [chemical binding]; other site 360911008261 Q-loop/lid; other site 360911008262 ABC transporter signature motif; other site 360911008263 Walker B; other site 360911008264 D-loop; other site 360911008265 H-loop/switch region; other site 360911008266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360911008267 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 360911008268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360911008269 Walker A/P-loop; other site 360911008270 ATP binding site [chemical binding]; other site 360911008271 Q-loop/lid; other site 360911008272 ABC transporter signature motif; other site 360911008273 Walker B; other site 360911008274 D-loop; other site 360911008275 H-loop/switch region; other site 360911008276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360911008277 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 360911008278 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 360911008279 ArsC family; Region: ArsC; pfam03960 360911008280 putative catalytic residues [active] 360911008281 thiol/disulfide switch; other site 360911008282 adaptor protein; Provisional; Region: PRK02315 360911008283 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 360911008284 Predicted membrane protein [Function unknown]; Region: COG4325 360911008285 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 360911008286 classical (c) SDRs; Region: SDR_c; cd05233 360911008287 NAD(P) binding site [chemical binding]; other site 360911008288 active site 360911008289 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 360911008290 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360911008291 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 360911008292 putative active site [active] 360911008293 catalytic site [active] 360911008294 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 360911008295 putative active site [active] 360911008296 catalytic site [active] 360911008297 Competence protein CoiA-like family; Region: CoiA; cl11541 360911008298 oligoendopeptidase F; Region: pepF; TIGR00181 360911008299 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 360911008300 active site 360911008301 Zn binding site [ion binding]; other site 360911008302 Thioredoxin; Region: Thioredoxin_5; pfam13743 360911008303 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 360911008304 putative active site [active] 360911008305 putative metal binding residues [ion binding]; other site 360911008306 signature motif; other site 360911008307 putative triphosphate binding site [ion binding]; other site 360911008308 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360911008309 synthetase active site [active] 360911008310 NTP binding site [chemical binding]; other site 360911008311 metal binding site [ion binding]; metal-binding site 360911008312 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 360911008313 ATP-NAD kinase; Region: NAD_kinase; pfam01513 360911008314 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 360911008315 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 360911008316 active site 360911008317 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 360911008318 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 360911008319 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 360911008320 NAD binding site [chemical binding]; other site 360911008321 homotetramer interface [polypeptide binding]; other site 360911008322 homodimer interface [polypeptide binding]; other site 360911008323 substrate binding site [chemical binding]; other site 360911008324 active site 360911008325 hypothetical protein; Provisional; Region: PRK13679 360911008326 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 360911008327 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 360911008328 tetramer interfaces [polypeptide binding]; other site 360911008329 binuclear metal-binding site [ion binding]; other site 360911008330 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 360911008331 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 360911008332 active site 360911008333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360911008334 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360911008335 Coenzyme A binding pocket [chemical binding]; other site 360911008336 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 360911008337 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 360911008338 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360911008339 Predicted flavoprotein [General function prediction only]; Region: COG0431 360911008340 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 360911008341 Virulence factor; Region: Virulence_fact; pfam13769 360911008342 HEAT repeats; Region: HEAT_2; pfam13646 360911008343 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 360911008344 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 360911008345 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 360911008346 homodimer interface [polypeptide binding]; other site 360911008347 NAD binding pocket [chemical binding]; other site 360911008348 ATP binding pocket [chemical binding]; other site 360911008349 Mg binding site [ion binding]; other site 360911008350 active-site loop [active] 360911008351 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 360911008352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360911008353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360911008354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360911008355 dimerization interface [polypeptide binding]; other site 360911008356 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 360911008357 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 360911008358 metal binding site [ion binding]; metal-binding site 360911008359 putative dimer interface [polypeptide binding]; other site 360911008360 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 360911008361 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 360911008362 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 360911008363 TrkA-N domain; Region: TrkA_N; pfam02254 360911008364 TrkA-C domain; Region: TrkA_C; pfam02080 360911008365 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 360911008366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911008367 active site 360911008368 motif I; other site 360911008369 motif II; other site 360911008370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360911008371 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 360911008372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 360911008373 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 360911008374 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 360911008375 putative active site [active] 360911008376 putative catalytic site [active] 360911008377 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 360911008378 PLD-like domain; Region: PLDc_2; pfam13091 360911008379 putative active site [active] 360911008380 putative catalytic site [active] 360911008381 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 360911008382 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 360911008383 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 360911008384 nucleophilic elbow; other site 360911008385 catalytic triad; other site 360911008386 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 360911008387 active site 360911008388 catalytic residues [active] 360911008389 metal binding site [ion binding]; metal-binding site 360911008390 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 360911008391 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 360911008392 TPP-binding site [chemical binding]; other site 360911008393 tetramer interface [polypeptide binding]; other site 360911008394 heterodimer interface [polypeptide binding]; other site 360911008395 phosphorylation loop region [posttranslational modification] 360911008396 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 360911008397 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 360911008398 alpha subunit interface [polypeptide binding]; other site 360911008399 TPP binding site [chemical binding]; other site 360911008400 heterodimer interface [polypeptide binding]; other site 360911008401 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360911008402 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 360911008403 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360911008404 E3 interaction surface; other site 360911008405 lipoyl attachment site [posttranslational modification]; other site 360911008406 e3 binding domain; Region: E3_binding; pfam02817 360911008407 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 360911008408 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 360911008409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360911008410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911008411 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360911008412 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 360911008413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911008414 Coenzyme A binding pocket [chemical binding]; other site 360911008415 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 360911008416 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 360911008417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360911008418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360911008419 catalytic residue [active] 360911008420 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 360911008421 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 360911008422 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 360911008423 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 360911008424 active site 360911008425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360911008426 Coenzyme A binding pocket [chemical binding]; other site 360911008427 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 360911008428 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 360911008429 G1 box; other site 360911008430 putative GEF interaction site [polypeptide binding]; other site 360911008431 GTP/Mg2+ binding site [chemical binding]; other site 360911008432 Switch I region; other site 360911008433 G2 box; other site 360911008434 G3 box; other site 360911008435 Switch II region; other site 360911008436 G4 box; other site 360911008437 G5 box; other site 360911008438 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 360911008439 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 360911008440 YlaH-like protein; Region: YlaH; pfam14036 360911008441 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 360911008442 hypothetical protein; Provisional; Region: PRK06733 360911008443 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 360911008444 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 360911008445 putative active site [active] 360911008446 PhoH-like protein; Region: PhoH; pfam02562 360911008447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360911008448 drug efflux system protein MdtG; Provisional; Region: PRK09874 360911008449 putative substrate translocation pore; other site 360911008450 hypothetical protein; Provisional; Region: PRK13666 360911008451 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 360911008452 pyruvate carboxylase; Reviewed; Region: PRK12999 360911008453 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911008454 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 360911008455 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 360911008456 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 360911008457 active site 360911008458 catalytic residues [active] 360911008459 metal binding site [ion binding]; metal-binding site 360911008460 homodimer binding site [polypeptide binding]; other site 360911008461 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 360911008462 carboxyltransferase (CT) interaction site; other site 360911008463 biotinylation site [posttranslational modification]; other site 360911008464 DNA photolyase; Region: DNA_photolyase; pfam00875 360911008465 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 360911008466 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 360911008467 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 360911008468 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 360911008469 UbiA prenyltransferase family; Region: UbiA; pfam01040 360911008470 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 360911008471 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 360911008472 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 360911008473 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 360911008474 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 360911008475 D-pathway; other site 360911008476 Putative ubiquinol binding site [chemical binding]; other site 360911008477 Low-spin heme (heme b) binding site [chemical binding]; other site 360911008478 Putative water exit pathway; other site 360911008479 Binuclear center (heme o3/CuB) [ion binding]; other site 360911008480 K-pathway; other site 360911008481 Putative proton exit pathway; other site 360911008482 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 360911008483 Subunit I/III interface [polypeptide binding]; other site 360911008484 Subunit III/IV interface [polypeptide binding]; other site 360911008485 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 360911008486 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 360911008487 Protein of unknown function (DUF420); Region: DUF420; pfam04238 360911008488 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 360911008489 Cu(I) binding site [ion binding]; other site 360911008490 YugN-like family; Region: YugN; pfam08868 360911008491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911008492 Protein of unknown function (DUF964); Region: DUF964; cl01483 360911008493 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 360911008494 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 360911008495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911008496 S-adenosylmethionine binding site [chemical binding]; other site 360911008497 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 360911008498 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 360911008499 active site 360911008500 (T/H)XGH motif; other site 360911008501 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 360911008502 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360911008503 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 360911008504 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 360911008505 hypothetical protein; Provisional; Region: PRK13670 360911008506 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 360911008507 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 360911008508 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 360911008509 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 360911008510 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 360911008511 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 360911008512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 360911008513 MraW methylase family; Region: Methyltransf_5; pfam01795 360911008514 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 360911008515 Cell division protein FtsL; Region: FtsL; cl11433 360911008516 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 360911008517 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360911008518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 360911008519 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 360911008520 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 360911008521 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 360911008522 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911008523 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911008524 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911008525 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 360911008526 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 360911008527 Mg++ binding site [ion binding]; other site 360911008528 putative catalytic motif [active] 360911008529 putative substrate binding site [chemical binding]; other site 360911008530 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 360911008531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911008532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911008533 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 360911008534 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 360911008535 active site 360911008536 homodimer interface [polypeptide binding]; other site 360911008537 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 360911008538 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 360911008539 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 360911008540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360911008541 nucleotide binding site [chemical binding]; other site 360911008542 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 360911008543 Cell division protein FtsA; Region: FtsA; pfam14450 360911008544 cell division protein FtsZ; Validated; Region: PRK09330 360911008545 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 360911008546 nucleotide binding site [chemical binding]; other site 360911008547 SulA interaction site; other site 360911008548 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 360911008549 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 360911008550 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 360911008551 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360911008552 catalytic residue [active] 360911008553 Protein of unknown function (DUF552); Region: DUF552; cl00775 360911008554 YGGT family; Region: YGGT; pfam02325 360911008555 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 360911008556 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911008557 RNA binding surface [nucleotide binding]; other site 360911008558 DivIVA protein; Region: DivIVA; pfam05103 360911008559 DivIVA domain; Region: DivI1A_domain; TIGR03544 360911008560 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 360911008561 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360911008562 active site 360911008563 HIGH motif; other site 360911008564 nucleotide binding site [chemical binding]; other site 360911008565 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 360911008566 active site 360911008567 KMSKS motif; other site 360911008568 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 360911008569 tRNA binding surface [nucleotide binding]; other site 360911008570 anticodon binding site; other site 360911008571 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 360911008572 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 360911008573 lipoprotein signal peptidase; Provisional; Region: PRK14787 360911008574 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 360911008575 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360911008576 RNA binding surface [nucleotide binding]; other site 360911008577 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 360911008578 active site 360911008579 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 360911008580 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911008581 active site 360911008582 uracil transporter; Provisional; Region: PRK10720 360911008583 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 360911008584 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360911008585 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 360911008586 dihydroorotase; Validated; Region: pyrC; PRK09357 360911008587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360911008588 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 360911008589 active site 360911008590 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 360911008591 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 360911008592 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 360911008593 catalytic site [active] 360911008594 subunit interface [polypeptide binding]; other site 360911008595 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 360911008596 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911008597 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 360911008598 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 360911008599 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360911008600 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911008601 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 360911008602 IMP binding site; other site 360911008603 dimer interface [polypeptide binding]; other site 360911008604 interdomain contacts; other site 360911008605 partial ornithine binding site; other site 360911008606 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 360911008607 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 360911008608 FAD binding pocket [chemical binding]; other site 360911008609 FAD binding motif [chemical binding]; other site 360911008610 phosphate binding motif [ion binding]; other site 360911008611 beta-alpha-beta structure motif; other site 360911008612 NAD binding pocket [chemical binding]; other site 360911008613 Iron coordination center [ion binding]; other site 360911008614 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 360911008615 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 360911008616 heterodimer interface [polypeptide binding]; other site 360911008617 active site 360911008618 FMN binding site [chemical binding]; other site 360911008619 homodimer interface [polypeptide binding]; other site 360911008620 substrate binding site [chemical binding]; other site 360911008621 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 360911008622 active site 360911008623 dimer interface [polypeptide binding]; other site 360911008624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360911008625 active site 360911008626 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 360911008627 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 360911008628 Domain of unknown function (DUF814); Region: DUF814; pfam05670 360911008629 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 360911008630 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 360911008631 catalytic site [active] 360911008632 G-X2-G-X-G-K; other site 360911008633 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 360911008634 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 360911008635 Flavoprotein; Region: Flavoprotein; pfam02441 360911008636 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 360911008637 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 360911008638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911008639 ATP binding site [chemical binding]; other site 360911008640 putative Mg++ binding site [ion binding]; other site 360911008641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911008642 nucleotide binding region [chemical binding]; other site 360911008643 ATP-binding site [chemical binding]; other site 360911008644 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 360911008645 active site 360911008646 catalytic residues [active] 360911008647 metal binding site [ion binding]; metal-binding site 360911008648 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 360911008649 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 360911008650 putative active site [active] 360911008651 substrate binding site [chemical binding]; other site 360911008652 putative cosubstrate binding site; other site 360911008653 catalytic site [active] 360911008654 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 360911008655 substrate binding site [chemical binding]; other site 360911008656 16S rRNA methyltransferase B; Provisional; Region: PRK14902 360911008657 NusB family; Region: NusB; pfam01029 360911008658 putative RNA binding site [nucleotide binding]; other site 360911008659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911008660 S-adenosylmethionine binding site [chemical binding]; other site 360911008661 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 360911008662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360911008663 FeS/SAM binding site; other site 360911008664 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 360911008665 Protein phosphatase 2C; Region: PP2C; pfam00481 360911008666 active site 360911008667 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360911008668 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 360911008669 active site 360911008670 ATP binding site [chemical binding]; other site 360911008671 substrate binding site [chemical binding]; other site 360911008672 activation loop (A-loop); other site 360911008673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 360911008674 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 360911008675 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 360911008676 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 360911008677 GTPase RsgA; Reviewed; Region: PRK00098 360911008678 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 360911008679 RNA binding site [nucleotide binding]; other site 360911008680 homodimer interface [polypeptide binding]; other site 360911008681 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 360911008682 GTPase/Zn-binding domain interface [polypeptide binding]; other site 360911008683 GTP/Mg2+ binding site [chemical binding]; other site 360911008684 G4 box; other site 360911008685 G5 box; other site 360911008686 G1 box; other site 360911008687 Switch I region; other site 360911008688 G2 box; other site 360911008689 G3 box; other site 360911008690 Switch II region; other site 360911008691 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 360911008692 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 360911008693 substrate binding site [chemical binding]; other site 360911008694 hexamer interface [polypeptide binding]; other site 360911008695 metal binding site [ion binding]; metal-binding site 360911008696 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 360911008697 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 360911008698 Thiamine pyrophosphokinase; Region: TPK; cd07995 360911008699 active site 360911008700 dimerization interface [polypeptide binding]; other site 360911008701 thiamine binding site [chemical binding]; other site 360911008702 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 360911008703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 360911008704 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 360911008705 DAK2 domain; Region: Dak2; pfam02734 360911008706 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 360911008707 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 360911008708 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 360911008709 putative L-serine binding site [chemical binding]; other site 360911008710 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 360911008711 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 360911008712 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 360911008713 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 360911008714 ssDNA binding site; other site 360911008715 generic binding surface II; other site 360911008716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911008717 ATP binding site [chemical binding]; other site 360911008718 putative Mg++ binding site [ion binding]; other site 360911008719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911008720 nucleotide binding region [chemical binding]; other site 360911008721 ATP-binding site [chemical binding]; other site 360911008722 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 360911008723 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 360911008724 active site 2 [active] 360911008725 putative phosphate acyltransferase; Provisional; Region: PRK05331 360911008726 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 360911008727 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 360911008728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 360911008729 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 360911008730 NAD(P) binding site [chemical binding]; other site 360911008731 homotetramer interface [polypeptide binding]; other site 360911008732 homodimer interface [polypeptide binding]; other site 360911008733 active site 360911008734 acyl carrier protein; Provisional; Region: acpP; PRK00982 360911008735 ribonuclease III; Reviewed; Region: rnc; PRK00102 360911008736 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 360911008737 dimerization interface [polypeptide binding]; other site 360911008738 active site 360911008739 metal binding site [ion binding]; metal-binding site 360911008740 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 360911008741 dsRNA binding site [nucleotide binding]; other site 360911008742 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 360911008743 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 360911008744 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 360911008745 Walker A/P-loop; other site 360911008746 ATP binding site [chemical binding]; other site 360911008747 Q-loop/lid; other site 360911008748 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 360911008749 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 360911008750 ABC transporter signature motif; other site 360911008751 Walker B; other site 360911008752 D-loop; other site 360911008753 H-loop/switch region; other site 360911008754 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 360911008755 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 360911008756 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 360911008757 P loop; other site 360911008758 GTP binding site [chemical binding]; other site 360911008759 putative DNA-binding protein; Validated; Region: PRK00118 360911008760 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 360911008761 signal recognition particle protein; Provisional; Region: PRK10867 360911008762 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 360911008763 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 360911008764 P loop; other site 360911008765 GTP binding site [chemical binding]; other site 360911008766 Signal peptide binding domain; Region: SRP_SPB; pfam02978 360911008767 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 360911008768 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 360911008769 RimM N-terminal domain; Region: RimM; pfam01782 360911008770 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 360911008771 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 360911008772 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 360911008773 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 360911008774 Catalytic site [active] 360911008775 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 360911008776 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 360911008777 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 360911008778 GTP/Mg2+ binding site [chemical binding]; other site 360911008779 G4 box; other site 360911008780 G5 box; other site 360911008781 G1 box; other site 360911008782 Switch I region; other site 360911008783 G2 box; other site 360911008784 G3 box; other site 360911008785 Switch II region; other site 360911008786 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 360911008787 RNA/DNA hybrid binding site [nucleotide binding]; other site 360911008788 active site 360911008789 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 360911008790 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 360911008791 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 360911008792 CoA-ligase; Region: Ligase_CoA; pfam00549 360911008793 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 360911008794 CoA binding domain; Region: CoA_binding; smart00881 360911008795 CoA-ligase; Region: Ligase_CoA; pfam00549 360911008796 DNA protecting protein DprA; Region: dprA; TIGR00732 360911008797 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 360911008798 DNA topoisomerase I; Validated; Region: PRK05582 360911008799 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 360911008800 active site 360911008801 interdomain interaction site; other site 360911008802 putative metal-binding site [ion binding]; other site 360911008803 nucleotide binding site [chemical binding]; other site 360911008804 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 360911008805 domain I; other site 360911008806 DNA binding groove [nucleotide binding] 360911008807 phosphate binding site [ion binding]; other site 360911008808 domain II; other site 360911008809 domain III; other site 360911008810 nucleotide binding site [chemical binding]; other site 360911008811 catalytic site [active] 360911008812 domain IV; other site 360911008813 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911008814 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360911008815 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 360911008816 Glucose inhibited division protein A; Region: GIDA; pfam01134 360911008817 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 360911008818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360911008819 active site 360911008820 DNA binding site [nucleotide binding] 360911008821 Int/Topo IB signature motif; other site 360911008822 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 360911008823 active site 360911008824 HslU subunit interaction site [polypeptide binding]; other site 360911008825 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 360911008826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360911008827 Walker A motif; other site 360911008828 ATP binding site [chemical binding]; other site 360911008829 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 360911008830 Walker B motif; other site 360911008831 arginine finger; other site 360911008832 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360911008833 transcriptional repressor CodY; Validated; Region: PRK04158 360911008834 CodY GAF-like domain; Region: CodY; pfam06018 360911008835 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 360911008836 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 360911008837 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 360911008838 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 360911008839 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360911008840 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360911008841 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 360911008842 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 360911008843 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 360911008844 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 360911008845 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 360911008846 FliG C-terminal domain; Region: FliG_C; pfam01706 360911008847 flagellar assembly protein H; Validated; Region: fliH; PRK06669 360911008848 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 360911008849 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 360911008850 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 360911008851 Walker A motif/ATP binding site; other site 360911008852 Walker B motif; other site 360911008853 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 360911008854 Flagellar FliJ protein; Region: FliJ; pfam02050 360911008855 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 360911008856 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 360911008857 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 360911008858 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 360911008859 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360911008860 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360911008861 Flagellar protein (FlbD); Region: FlbD; pfam06289 360911008862 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 360911008863 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 360911008864 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 360911008865 flagellar motor switch protein; Validated; Region: PRK08119 360911008866 CheC-like family; Region: CheC; pfam04509 360911008867 CheC-like family; Region: CheC; pfam04509 360911008868 flagellar motor switch protein FliN; Region: fliN; TIGR02480 360911008869 Response regulator receiver domain; Region: Response_reg; pfam00072 360911008870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360911008871 active site 360911008872 phosphorylation site [posttranslational modification] 360911008873 intermolecular recognition site; other site 360911008874 dimerization interface [polypeptide binding]; other site 360911008875 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 360911008876 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 360911008877 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 360911008878 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 360911008879 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 360911008880 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 360911008881 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 360911008882 FHIPEP family; Region: FHIPEP; pfam00771 360911008883 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 360911008884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 360911008885 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 360911008886 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 360911008887 P-loop; other site 360911008888 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 360911008889 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 360911008890 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 360911008891 putative binding surface; other site 360911008892 active site 360911008893 P2 response regulator binding domain; Region: P2; pfam07194 360911008894 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 360911008895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360911008896 ATP binding site [chemical binding]; other site 360911008897 Mg2+ binding site [ion binding]; other site 360911008898 G-X-G motif; other site 360911008899 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 360911008900 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 360911008901 putative CheA interaction surface; other site 360911008902 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 360911008903 CheC-like family; Region: CheC; pfam04509 360911008904 Chemotaxis phosphatase CheX; Region: CheX; cl15816 360911008905 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 360911008906 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 360911008907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360911008908 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360911008909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360911008910 DNA binding residues [nucleotide binding] 360911008911 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 360911008912 rRNA interaction site [nucleotide binding]; other site 360911008913 S8 interaction site; other site 360911008914 putative laminin-1 binding site; other site 360911008915 elongation factor Ts; Provisional; Region: tsf; PRK09377 360911008916 UBA/TS-N domain; Region: UBA; pfam00627 360911008917 Elongation factor TS; Region: EF_TS; pfam00889 360911008918 Elongation factor TS; Region: EF_TS; pfam00889 360911008919 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 360911008920 putative nucleotide binding site [chemical binding]; other site 360911008921 uridine monophosphate binding site [chemical binding]; other site 360911008922 homohexameric interface [polypeptide binding]; other site 360911008923 ribosome recycling factor; Reviewed; Region: frr; PRK00083 360911008924 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 360911008925 hinge region; other site 360911008926 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 360911008927 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 360911008928 catalytic residue [active] 360911008929 putative FPP diphosphate binding site; other site 360911008930 putative FPP binding hydrophobic cleft; other site 360911008931 dimer interface [polypeptide binding]; other site 360911008932 putative IPP diphosphate binding site; other site 360911008933 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 360911008934 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 360911008935 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 360911008936 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 360911008937 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 360911008938 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 360911008939 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 360911008940 RIP metalloprotease RseP; Region: TIGR00054 360911008941 active site 360911008942 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 360911008943 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 360911008944 protein binding site [polypeptide binding]; other site 360911008945 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 360911008946 putative substrate binding region [chemical binding]; other site 360911008947 prolyl-tRNA synthetase; Provisional; Region: PRK09194 360911008948 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 360911008949 dimer interface [polypeptide binding]; other site 360911008950 motif 1; other site 360911008951 active site 360911008952 motif 2; other site 360911008953 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 360911008954 putative deacylase active site [active] 360911008955 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 360911008956 active site 360911008957 motif 3; other site 360911008958 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 360911008959 anticodon binding site; other site 360911008960 DNA polymerase III PolC; Validated; Region: polC; PRK00448 360911008961 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 360911008962 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 360911008963 generic binding surface II; other site 360911008964 generic binding surface I; other site 360911008965 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 360911008966 active site 360911008967 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 360911008968 active site 360911008969 catalytic site [active] 360911008970 substrate binding site [chemical binding]; other site 360911008971 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 360911008972 ribosome maturation protein RimP; Reviewed; Region: PRK00092 360911008973 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 360911008974 putative oligomer interface [polypeptide binding]; other site 360911008975 putative RNA binding site [nucleotide binding]; other site 360911008976 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 360911008977 NusA N-terminal domain; Region: NusA_N; pfam08529 360911008978 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 360911008979 RNA binding site [nucleotide binding]; other site 360911008980 homodimer interface [polypeptide binding]; other site 360911008981 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 360911008982 G-X-X-G motif; other site 360911008983 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 360911008984 G-X-X-G motif; other site 360911008985 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 360911008986 putative RNA binding cleft [nucleotide binding]; other site 360911008987 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 360911008988 translation initiation factor IF-2; Validated; Region: infB; PRK05306 360911008989 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 360911008990 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 360911008991 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 360911008992 G1 box; other site 360911008993 putative GEF interaction site [polypeptide binding]; other site 360911008994 GTP/Mg2+ binding site [chemical binding]; other site 360911008995 Switch I region; other site 360911008996 G2 box; other site 360911008997 G3 box; other site 360911008998 Switch II region; other site 360911008999 G4 box; other site 360911009000 G5 box; other site 360911009001 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 360911009002 Translation-initiation factor 2; Region: IF-2; pfam11987 360911009003 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 360911009004 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 360911009005 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 360911009006 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 360911009007 RNA binding site [nucleotide binding]; other site 360911009008 active site 360911009009 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 360911009010 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 360911009011 active site 360911009012 Riboflavin kinase; Region: Flavokinase; smart00904 360911009013 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 360911009014 16S/18S rRNA binding site [nucleotide binding]; other site 360911009015 S13e-L30e interaction site [polypeptide binding]; other site 360911009016 25S rRNA binding site [nucleotide binding]; other site 360911009017 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 360911009018 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 360911009019 RNase E interface [polypeptide binding]; other site 360911009020 trimer interface [polypeptide binding]; other site 360911009021 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 360911009022 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 360911009023 RNase E interface [polypeptide binding]; other site 360911009024 trimer interface [polypeptide binding]; other site 360911009025 active site 360911009026 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 360911009027 putative nucleic acid binding region [nucleotide binding]; other site 360911009028 G-X-X-G motif; other site 360911009029 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 360911009030 RNA binding site [nucleotide binding]; other site 360911009031 domain interface; other site 360911009032 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360911009033 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 360911009034 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360911009035 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 360911009036 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360911009037 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360911009038 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360911009039 FemAB family; Region: FemAB; pfam02388 360911009040 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 360911009041 Peptidase M15; Region: Peptidase_M15_3; cl01194 360911009042 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 360911009043 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 360911009044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 360911009045 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 360911009046 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 360911009047 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 360911009048 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 360911009049 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 360911009050 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360911009051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360911009052 DNA-binding site [nucleotide binding]; DNA binding site 360911009053 UTRA domain; Region: UTRA; pfam07702 360911009054 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 360911009055 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 360911009056 ligand binding site [chemical binding]; other site 360911009057 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 360911009058 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360911009059 Walker A/P-loop; other site 360911009060 ATP binding site [chemical binding]; other site 360911009061 Q-loop/lid; other site 360911009062 ABC transporter signature motif; other site 360911009063 Walker B; other site 360911009064 D-loop; other site 360911009065 H-loop/switch region; other site 360911009066 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360911009067 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360911009068 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 360911009069 TM-ABC transporter signature motif; other site 360911009070 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360911009071 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 360911009072 TM-ABC transporter signature motif; other site 360911009073 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 360911009074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 360911009075 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 360911009076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911009077 ATP binding site [chemical binding]; other site 360911009078 putative Mg++ binding site [ion binding]; other site 360911009079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911009080 nucleotide binding region [chemical binding]; other site 360911009081 ATP-binding site [chemical binding]; other site 360911009082 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 360911009083 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 360911009084 DNA binding residues [nucleotide binding] 360911009085 B12 binding domain; Region: B12-binding_2; pfam02607 360911009086 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 360911009087 B12 binding site [chemical binding]; other site 360911009088 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 360911009089 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 360911009090 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 360911009091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360911009092 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 360911009093 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 360911009094 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 360911009095 NAD(P) binding site [chemical binding]; other site 360911009096 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 360911009097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 360911009098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360911009099 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 360911009100 active site 360911009101 homotetramer interface [polypeptide binding]; other site 360911009102 homodimer interface [polypeptide binding]; other site 360911009103 Protease prsW family; Region: PrsW-protease; pfam13367 360911009104 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 360911009105 Flagellar protein YcgR; Region: YcgR_2; pfam12945 360911009106 PilZ domain; Region: PilZ; pfam07238 360911009107 cytidylate kinase; Provisional; Region: cmk; PRK00023 360911009108 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 360911009109 CMP-binding site; other site 360911009110 The sites determining sugar specificity; other site 360911009111 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 360911009112 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360911009113 putative acyl-acceptor binding pocket; other site 360911009114 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 360911009115 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 360911009116 RNA binding site [nucleotide binding]; other site 360911009117 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 360911009118 RNA binding site [nucleotide binding]; other site 360911009119 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 360911009120 RNA binding site [nucleotide binding]; other site 360911009121 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360911009122 RNA binding site [nucleotide binding]; other site 360911009123 GTP-binding protein Der; Reviewed; Region: PRK00093 360911009124 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 360911009125 G1 box; other site 360911009126 GTP/Mg2+ binding site [chemical binding]; other site 360911009127 Switch I region; other site 360911009128 G2 box; other site 360911009129 Switch II region; other site 360911009130 G3 box; other site 360911009131 G4 box; other site 360911009132 G5 box; other site 360911009133 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 360911009134 G1 box; other site 360911009135 GTP/Mg2+ binding site [chemical binding]; other site 360911009136 Switch I region; other site 360911009137 G2 box; other site 360911009138 G3 box; other site 360911009139 Switch II region; other site 360911009140 G4 box; other site 360911009141 G5 box; other site 360911009142 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 360911009143 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 360911009144 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 360911009145 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 360911009146 IHF dimer interface [polypeptide binding]; other site 360911009147 IHF - DNA interface [nucleotide binding]; other site 360911009148 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 360911009149 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 360911009150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360911009151 S-adenosylmethionine binding site [chemical binding]; other site 360911009152 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 360911009153 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 360911009154 substrate binding pocket [chemical binding]; other site 360911009155 chain length determination region; other site 360911009156 substrate-Mg2+ binding site; other site 360911009157 catalytic residues [active] 360911009158 aspartate-rich region 1; other site 360911009159 active site lid residues [active] 360911009160 aspartate-rich region 2; other site 360911009161 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 360911009162 active site 360911009163 multimer interface [polypeptide binding]; other site 360911009164 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 360911009165 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 360911009166 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 360911009167 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 360911009168 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 360911009169 Tetramer interface [polypeptide binding]; other site 360911009170 active site 360911009171 FMN-binding site [chemical binding]; other site 360911009172 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 360911009173 active site 360911009174 dimer interface [polypeptide binding]; other site 360911009175 metal binding site [ion binding]; metal-binding site 360911009176 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 360911009177 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 360911009178 hinge; other site 360911009179 active site 360911009180 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 360911009181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911009182 TPR motif; other site 360911009183 binding surface 360911009184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360911009185 binding surface 360911009186 TPR motif; other site 360911009187 hypothetical protein; Provisional; Region: PRK03636 360911009188 UPF0302 domain; Region: UPF0302; pfam08864 360911009189 IDEAL domain; Region: IDEAL; pfam08858 360911009190 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 360911009191 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 360911009192 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 360911009193 iron-sulfur cluster [ion binding]; other site 360911009194 [2Fe-2S] cluster binding site [ion binding]; other site 360911009195 cytochrome b6; Provisional; Region: PRK03735 360911009196 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 360911009197 interchain domain interface [polypeptide binding]; other site 360911009198 intrachain domain interface; other site 360911009199 heme bH binding site [chemical binding]; other site 360911009200 heme bL binding site [chemical binding]; other site 360911009201 Qo binding site; other site 360911009202 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 360911009203 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 360911009204 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 360911009205 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 360911009206 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 360911009207 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360911009208 Uncharacterized conserved protein [Function unknown]; Region: COG1284 360911009209 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911009210 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 360911009211 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 360911009212 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 360911009213 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 360911009214 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 360911009215 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 360911009216 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 360911009217 active site 360911009218 NTP binding site [chemical binding]; other site 360911009219 metal binding triad [ion binding]; metal-binding site 360911009220 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 360911009221 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 360911009222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360911009223 putative DNA binding site [nucleotide binding]; other site 360911009224 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 360911009225 putative Zn2+ binding site [ion binding]; other site 360911009226 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 360911009227 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 360911009228 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 360911009229 oligomerization interface [polypeptide binding]; other site 360911009230 active site 360911009231 metal binding site [ion binding]; metal-binding site 360911009232 pantoate--beta-alanine ligase; Region: panC; TIGR00018 360911009233 Pantoate-beta-alanine ligase; Region: PanC; cd00560 360911009234 active site 360911009235 ATP-binding site [chemical binding]; other site 360911009236 pantoate-binding site; other site 360911009237 HXXH motif; other site 360911009238 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 360911009239 tetramerization interface [polypeptide binding]; other site 360911009240 active site 360911009241 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 360911009242 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 360911009243 active site 360911009244 catalytic site [active] 360911009245 substrate binding site [chemical binding]; other site 360911009246 DEAD/DEAH box helicase; Region: DEAD; pfam00270 360911009247 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 360911009248 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 360911009249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 360911009250 aspartate aminotransferase; Provisional; Region: PRK05764 360911009251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360911009252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360911009253 homodimer interface [polypeptide binding]; other site 360911009254 catalytic residue [active] 360911009255 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 360911009256 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 360911009257 putative dimer interface [polypeptide binding]; other site 360911009258 putative anticodon binding site; other site 360911009259 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 360911009260 homodimer interface [polypeptide binding]; other site 360911009261 motif 1; other site 360911009262 motif 2; other site 360911009263 active site 360911009264 motif 3; other site 360911009265 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 360911009266 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 360911009267 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 360911009268 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360911009269 minor groove reading motif; other site 360911009270 helix-hairpin-helix signature motif; other site 360911009271 substrate binding pocket [chemical binding]; other site 360911009272 active site 360911009273 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 360911009274 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 360911009275 Transglycosylase; Region: Transgly; pfam00912 360911009276 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 360911009277 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 360911009278 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 360911009279 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360911009280 ATP binding site [chemical binding]; other site 360911009281 putative Mg++ binding site [ion binding]; other site 360911009282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360911009283 nucleotide binding region [chemical binding]; other site 360911009284 ATP-binding site [chemical binding]; other site 360911009285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360911009286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911009287 non-specific DNA binding site [nucleotide binding]; other site 360911009288 salt bridge; other site 360911009289 sequence-specific DNA binding site [nucleotide binding]; other site 360911009290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360911009291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360911009292 non-specific DNA binding site [nucleotide binding]; other site 360911009293 salt bridge; other site 360911009294 sequence-specific DNA binding site [nucleotide binding]; other site 360911009295 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 360911009296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911009297 Walker A/P-loop; other site 360911009298 ATP binding site [chemical binding]; other site 360911009299 HNH endonuclease; Region: HNH_3; pfam13392 360911009300 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 360911009301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360911009302 Q-loop/lid; other site 360911009303 ABC transporter signature motif; other site 360911009304 Walker B; other site 360911009305 D-loop; other site 360911009306 H-loop/switch region; other site 360911009307 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 360911009308 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360911009309 active site 360911009310 metal binding site [ion binding]; metal-binding site 360911009311 DNA binding site [nucleotide binding]