-- dump date 20140619_092312 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1399115000001 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1399115000002 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1399115000003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115000004 catalytic residue [active] 1399115000005 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1399115000006 thymidylate kinase; Validated; Region: tmk; PRK00698 1399115000007 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1399115000008 TMP-binding site; other site 1399115000009 ATP-binding site [chemical binding]; other site 1399115000010 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1399115000011 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1399115000012 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1399115000013 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1399115000014 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1399115000015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115000016 S-adenosylmethionine binding site [chemical binding]; other site 1399115000017 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1399115000018 GIY-YIG motif/motif A; other site 1399115000019 putative active site [active] 1399115000020 putative metal binding site [ion binding]; other site 1399115000021 Predicted methyltransferases [General function prediction only]; Region: COG0313 1399115000022 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1399115000023 putative SAM binding site [chemical binding]; other site 1399115000024 putative homodimer interface [polypeptide binding]; other site 1399115000025 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1399115000026 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1399115000027 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1399115000028 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1399115000029 active site 1399115000030 HIGH motif; other site 1399115000031 KMSKS motif; other site 1399115000032 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1399115000033 tRNA binding surface [nucleotide binding]; other site 1399115000034 anticodon binding site; other site 1399115000035 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1399115000036 dimer interface [polypeptide binding]; other site 1399115000037 putative tRNA-binding site [nucleotide binding]; other site 1399115000038 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1399115000039 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1399115000040 active site 1399115000041 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1399115000042 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1399115000043 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1399115000044 G5 domain; Region: G5; pfam07501 1399115000045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1399115000046 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1399115000047 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1399115000048 putative active site [active] 1399115000049 putative metal binding site [ion binding]; other site 1399115000050 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1399115000051 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1399115000052 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1399115000053 S-adenosylmethionine binding site [chemical binding]; other site 1399115000054 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1399115000055 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1399115000056 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1399115000057 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1399115000058 pur operon repressor; Provisional; Region: PRK09213 1399115000059 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1399115000060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115000061 active site 1399115000062 regulatory protein SpoVG; Reviewed; Region: PRK13259 1399115000063 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1399115000064 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1399115000065 Substrate binding site; other site 1399115000066 Mg++ binding site; other site 1399115000067 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1399115000068 active site 1399115000069 substrate binding site [chemical binding]; other site 1399115000070 CoA binding site [chemical binding]; other site 1399115000071 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1399115000072 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1399115000073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115000074 active site 1399115000075 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1399115000076 putative active site [active] 1399115000077 catalytic residue [active] 1399115000078 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1399115000079 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1399115000080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115000081 ATP binding site [chemical binding]; other site 1399115000082 putative Mg++ binding site [ion binding]; other site 1399115000083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115000084 nucleotide binding region [chemical binding]; other site 1399115000085 ATP-binding site [chemical binding]; other site 1399115000086 TRCF domain; Region: TRCF; pfam03461 1399115000087 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1399115000088 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1399115000089 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1399115000090 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1399115000091 putative SAM binding site [chemical binding]; other site 1399115000092 putative homodimer interface [polypeptide binding]; other site 1399115000093 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1399115000094 homodimer interface [polypeptide binding]; other site 1399115000095 metal binding site [ion binding]; metal-binding site 1399115000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1399115000097 homodimer interface [polypeptide binding]; other site 1399115000098 active site 1399115000099 putative chemical substrate binding site [chemical binding]; other site 1399115000100 metal binding site [ion binding]; metal-binding site 1399115000101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115000102 RNA binding surface [nucleotide binding]; other site 1399115000103 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1399115000104 Septum formation initiator; Region: DivIC; pfam04977 1399115000105 hypothetical protein; Provisional; Region: PRK08582 1399115000106 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1399115000107 RNA binding site [nucleotide binding]; other site 1399115000108 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1399115000109 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1399115000110 Ligand Binding Site [chemical binding]; other site 1399115000111 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1399115000112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115000113 active site 1399115000114 FtsH Extracellular; Region: FtsH_ext; pfam06480 1399115000115 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1399115000116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115000117 Walker A motif; other site 1399115000118 ATP binding site [chemical binding]; other site 1399115000119 Walker B motif; other site 1399115000120 arginine finger; other site 1399115000121 Peptidase family M41; Region: Peptidase_M41; pfam01434 1399115000122 pantothenate kinase; Reviewed; Region: PRK13318 1399115000123 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1399115000124 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1399115000125 dimerization interface [polypeptide binding]; other site 1399115000126 domain crossover interface; other site 1399115000127 redox-dependent activation switch; other site 1399115000128 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1399115000129 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1399115000130 dimer interface [polypeptide binding]; other site 1399115000131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115000132 catalytic residue [active] 1399115000133 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1399115000134 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1399115000135 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1399115000136 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1399115000137 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1399115000138 glutamine binding [chemical binding]; other site 1399115000139 catalytic triad [active] 1399115000140 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1399115000141 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1399115000142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115000143 catalytic residue [active] 1399115000144 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1399115000145 dihydropteroate synthase; Region: DHPS; TIGR01496 1399115000146 substrate binding pocket [chemical binding]; other site 1399115000147 dimer interface [polypeptide binding]; other site 1399115000148 inhibitor binding site; inhibition site 1399115000149 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1399115000150 homooctamer interface [polypeptide binding]; other site 1399115000151 active site 1399115000152 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1399115000153 catalytic center binding site [active] 1399115000154 ATP binding site [chemical binding]; other site 1399115000155 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1399115000156 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1399115000157 FMN binding site [chemical binding]; other site 1399115000158 active site 1399115000159 catalytic residues [active] 1399115000160 substrate binding site [chemical binding]; other site 1399115000161 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1399115000162 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1399115000163 dimer interface [polypeptide binding]; other site 1399115000164 putative anticodon binding site; other site 1399115000165 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1399115000166 motif 1; other site 1399115000167 active site 1399115000168 motif 2; other site 1399115000169 motif 3; other site 1399115000170 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1399115000171 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1399115000172 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1399115000173 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1399115000174 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1399115000175 ADP binding site [chemical binding]; other site 1399115000176 phosphagen binding site; other site 1399115000177 substrate specificity loop; other site 1399115000178 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1399115000179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115000180 catalytic residue [active] 1399115000181 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1399115000182 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1399115000183 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1399115000184 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1399115000185 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1399115000186 ADP binding site [chemical binding]; other site 1399115000187 phosphagen binding site; other site 1399115000188 substrate specificity loop; other site 1399115000189 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1399115000190 Clp amino terminal domain; Region: Clp_N; pfam02861 1399115000191 Clp amino terminal domain; Region: Clp_N; pfam02861 1399115000192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115000193 Walker A motif; other site 1399115000194 ATP binding site [chemical binding]; other site 1399115000195 Walker B motif; other site 1399115000196 arginine finger; other site 1399115000197 UvrB/uvrC motif; Region: UVR; pfam02151 1399115000198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115000199 Walker A motif; other site 1399115000200 ATP binding site [chemical binding]; other site 1399115000201 Walker B motif; other site 1399115000202 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1399115000203 DNA repair protein RadA; Provisional; Region: PRK11823 1399115000204 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1399115000205 Walker A motif/ATP binding site; other site 1399115000206 ATP binding site [chemical binding]; other site 1399115000207 Walker B motif; other site 1399115000208 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1399115000209 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1399115000210 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1399115000211 putative active site [active] 1399115000212 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1399115000213 substrate binding site; other site 1399115000214 dimer interface; other site 1399115000215 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1399115000216 homotrimer interaction site [polypeptide binding]; other site 1399115000217 zinc binding site [ion binding]; other site 1399115000218 CDP-binding sites; other site 1399115000219 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1399115000220 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1399115000221 HIGH motif; other site 1399115000222 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1399115000223 active site 1399115000224 KMSKS motif; other site 1399115000225 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1399115000226 serine O-acetyltransferase; Region: cysE; TIGR01172 1399115000227 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1399115000228 trimer interface [polypeptide binding]; other site 1399115000229 active site 1399115000230 substrate binding site [chemical binding]; other site 1399115000231 CoA binding site [chemical binding]; other site 1399115000232 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1399115000233 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1399115000234 active site 1399115000235 HIGH motif; other site 1399115000236 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1399115000237 KMSKS motif; other site 1399115000238 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1399115000239 tRNA binding surface [nucleotide binding]; other site 1399115000240 anticodon binding site; other site 1399115000241 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1399115000242 active site 1399115000243 metal binding site [ion binding]; metal-binding site 1399115000244 dimerization interface [polypeptide binding]; other site 1399115000245 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1399115000246 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1399115000247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1399115000248 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1399115000249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115000250 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1399115000251 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1399115000252 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1399115000253 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1399115000254 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1399115000255 putative homodimer interface [polypeptide binding]; other site 1399115000256 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1399115000257 heterodimer interface [polypeptide binding]; other site 1399115000258 homodimer interface [polypeptide binding]; other site 1399115000259 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1399115000260 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1399115000261 23S rRNA interface [nucleotide binding]; other site 1399115000262 L7/L12 interface [polypeptide binding]; other site 1399115000263 putative thiostrepton binding site; other site 1399115000264 L25 interface [polypeptide binding]; other site 1399115000265 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1399115000266 mRNA/rRNA interface [nucleotide binding]; other site 1399115000267 L10 leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115000268 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1399115000269 23S rRNA interface [nucleotide binding]; other site 1399115000270 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1399115000271 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1399115000272 peripheral dimer interface [polypeptide binding]; other site 1399115000273 core dimer interface [polypeptide binding]; other site 1399115000274 L10 interface [polypeptide binding]; other site 1399115000275 L11 interface [polypeptide binding]; other site 1399115000276 putative EF-Tu interaction site [polypeptide binding]; other site 1399115000277 putative EF-G interaction site [polypeptide binding]; other site 1399115000278 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1399115000279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115000280 S-adenosylmethionine binding site [chemical binding]; other site 1399115000281 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1399115000282 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1399115000283 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1399115000284 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1399115000285 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1399115000286 RPB10 interaction site [polypeptide binding]; other site 1399115000287 RPB1 interaction site [polypeptide binding]; other site 1399115000288 RPB11 interaction site [polypeptide binding]; other site 1399115000289 RPB3 interaction site [polypeptide binding]; other site 1399115000290 RPB12 interaction site [polypeptide binding]; other site 1399115000291 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1399115000292 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1399115000293 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1399115000294 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1399115000295 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1399115000296 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1399115000297 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1399115000298 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1399115000299 G-loop; other site 1399115000300 DNA binding site [nucleotide binding] 1399115000301 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1399115000302 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1399115000303 S17 interaction site [polypeptide binding]; other site 1399115000304 S8 interaction site; other site 1399115000305 16S rRNA interaction site [nucleotide binding]; other site 1399115000306 streptomycin interaction site [chemical binding]; other site 1399115000307 23S rRNA interaction site [nucleotide binding]; other site 1399115000308 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1399115000309 30S ribosomal protein S7; Validated; Region: PRK05302 1399115000310 elongation factor G; Reviewed; Region: PRK00007 1399115000311 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1399115000312 G1 box; other site 1399115000313 putative GEF interaction site [polypeptide binding]; other site 1399115000314 GTP/Mg2+ binding site [chemical binding]; other site 1399115000315 Switch I region; other site 1399115000316 G2 box; other site 1399115000317 G3 box; other site 1399115000318 Switch II region; other site 1399115000319 G4 box; other site 1399115000320 G5 box; other site 1399115000321 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1399115000322 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1399115000323 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1399115000324 elongation factor Tu; Reviewed; Region: PRK00049 1399115000325 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1399115000326 G1 box; other site 1399115000327 GEF interaction site [polypeptide binding]; other site 1399115000328 GTP/Mg2+ binding site [chemical binding]; other site 1399115000329 Switch I region; other site 1399115000330 G2 box; other site 1399115000331 G3 box; other site 1399115000332 Switch II region; other site 1399115000333 G4 box; other site 1399115000334 G5 box; other site 1399115000335 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1399115000336 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1399115000337 Antibiotic Binding Site [chemical binding]; other site 1399115000338 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1399115000339 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1399115000340 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1399115000341 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1399115000342 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1399115000343 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1399115000344 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1399115000345 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1399115000346 putative translocon binding site; other site 1399115000347 protein-rRNA interface [nucleotide binding]; other site 1399115000348 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1399115000349 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1399115000350 G-X-X-G motif; other site 1399115000351 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1399115000352 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1399115000353 23S rRNA interface [nucleotide binding]; other site 1399115000354 5S rRNA interface [nucleotide binding]; other site 1399115000355 putative antibiotic binding site [chemical binding]; other site 1399115000356 L25 interface [polypeptide binding]; other site 1399115000357 L27 interface [polypeptide binding]; other site 1399115000358 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1399115000359 23S rRNA interface [nucleotide binding]; other site 1399115000360 putative translocon interaction site; other site 1399115000361 signal recognition particle (SRP54) interaction site; other site 1399115000362 L23 interface [polypeptide binding]; other site 1399115000363 trigger factor interaction site; other site 1399115000364 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1399115000365 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1399115000366 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1399115000367 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1399115000368 RNA binding site [nucleotide binding]; other site 1399115000369 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1399115000370 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1399115000371 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1399115000372 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1399115000373 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1399115000374 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1399115000375 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1399115000376 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1399115000377 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1399115000378 5S rRNA interface [nucleotide binding]; other site 1399115000379 L27 interface [polypeptide binding]; other site 1399115000380 23S rRNA interface [nucleotide binding]; other site 1399115000381 L5 interface [polypeptide binding]; other site 1399115000382 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1399115000383 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1399115000384 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1399115000385 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1399115000386 23S rRNA binding site [nucleotide binding]; other site 1399115000387 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1399115000388 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1399115000389 SecY translocase; Region: SecY; pfam00344 1399115000390 adenylate kinase; Reviewed; Region: adk; PRK00279 1399115000391 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1399115000392 AMP-binding site [chemical binding]; other site 1399115000393 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1399115000394 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1399115000395 active site 1399115000396 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1399115000397 rRNA binding site [nucleotide binding]; other site 1399115000398 predicted 30S ribosome binding site; other site 1399115000399 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1399115000400 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1399115000401 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1399115000402 30S ribosomal protein S11; Validated; Region: PRK05309 1399115000403 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1399115000404 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1399115000405 alphaNTD - beta interaction site [polypeptide binding]; other site 1399115000406 alphaNTD homodimer interface [polypeptide binding]; other site 1399115000407 alphaNTD - beta' interaction site [polypeptide binding]; other site 1399115000408 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1399115000409 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1399115000410 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1399115000411 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1399115000412 Walker A/P-loop; other site 1399115000413 ATP binding site [chemical binding]; other site 1399115000414 Q-loop/lid; other site 1399115000415 ABC transporter signature motif; other site 1399115000416 Walker B; other site 1399115000417 D-loop; other site 1399115000418 H-loop/switch region; other site 1399115000419 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1399115000420 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1399115000421 Walker A/P-loop; other site 1399115000422 ATP binding site [chemical binding]; other site 1399115000423 Q-loop/lid; other site 1399115000424 ABC transporter signature motif; other site 1399115000425 Walker B; other site 1399115000426 D-loop; other site 1399115000427 H-loop/switch region; other site 1399115000428 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1399115000429 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1399115000430 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1399115000431 dimerization interface 3.5A [polypeptide binding]; other site 1399115000432 active site 1399115000433 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1399115000434 23S rRNA interface [nucleotide binding]; other site 1399115000435 L3 interface [polypeptide binding]; other site 1399115000436 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1399115000437 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1399115000438 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1399115000439 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1399115000440 Domain of unknown function DUF59; Region: DUF59; cl00941 1399115000441 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1399115000442 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1399115000443 Walker A motif; other site 1399115000444 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1399115000445 Arginase family; Region: Arginase; cd09989 1399115000446 agmatinase; Region: agmatinase; TIGR01230 1399115000447 active site 1399115000448 Mn binding site [ion binding]; other site 1399115000449 oligomer interface [polypeptide binding]; other site 1399115000450 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1399115000451 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115000452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115000453 DNA binding residues [nucleotide binding] 1399115000454 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1399115000455 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1399115000456 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1399115000457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1399115000458 YbbR-like protein; Region: YbbR; pfam07949 1399115000459 YbbR-like protein; Region: YbbR; pfam07949 1399115000460 YbbR-like protein; Region: YbbR; pfam07949 1399115000461 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1399115000462 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1399115000463 active site 1399115000464 substrate binding site [chemical binding]; other site 1399115000465 metal binding site [ion binding]; metal-binding site 1399115000466 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1399115000467 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1399115000468 glutaminase active site [active] 1399115000469 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1399115000470 dimer interface [polypeptide binding]; other site 1399115000471 active site 1399115000472 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1399115000473 dimer interface [polypeptide binding]; other site 1399115000474 active site 1399115000475 Esterase/lipase [General function prediction only]; Region: COG1647 1399115000476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1399115000477 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1399115000478 putative NAD(P) binding site [chemical binding]; other site 1399115000479 homodimer interface [polypeptide binding]; other site 1399115000480 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1399115000481 Isochorismatase family; Region: Isochorismatase; pfam00857 1399115000482 catalytic triad [active] 1399115000483 conserved cis-peptide bond; other site 1399115000484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115000485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115000486 Coenzyme A binding pocket [chemical binding]; other site 1399115000487 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115000488 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1399115000489 active site 1399115000490 ATP binding site [chemical binding]; other site 1399115000491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115000492 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1399115000493 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115000494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115000495 dimerization interface [polypeptide binding]; other site 1399115000496 putative DNA binding site [nucleotide binding]; other site 1399115000497 putative Zn2+ binding site [ion binding]; other site 1399115000498 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1399115000499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115000500 NAD(P) binding site [chemical binding]; other site 1399115000501 active site 1399115000502 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1399115000503 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115000504 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1399115000505 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1399115000506 ligand binding site [chemical binding]; other site 1399115000507 flexible hinge region; other site 1399115000508 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1399115000509 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115000510 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1399115000511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115000512 motif II; other site 1399115000513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115000514 Coenzyme A binding pocket [chemical binding]; other site 1399115000515 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1399115000516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115000517 Coenzyme A binding pocket [chemical binding]; other site 1399115000518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115000519 Dynamin family; Region: Dynamin_N; pfam00350 1399115000520 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1399115000521 G1 box; other site 1399115000522 GTP/Mg2+ binding site [chemical binding]; other site 1399115000523 G2 box; other site 1399115000524 Switch I region; other site 1399115000525 G3 box; other site 1399115000526 Switch II region; other site 1399115000527 G4 box; other site 1399115000528 G5 box; other site 1399115000529 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1399115000530 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1399115000531 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1399115000532 putative catalytic residues [active] 1399115000533 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1399115000534 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1399115000535 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1399115000536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1399115000537 active site 1399115000538 Cupin domain; Region: Cupin_2; cl17218 1399115000539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115000540 Response regulator receiver domain; Region: Response_reg; pfam00072 1399115000541 active site 1399115000542 phosphorylation site [posttranslational modification] 1399115000543 intermolecular recognition site; other site 1399115000544 dimerization interface [polypeptide binding]; other site 1399115000545 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1399115000546 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1399115000547 active site 1399115000548 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1399115000549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1399115000550 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1399115000551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1399115000552 active site 1399115000553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115000554 Predicted metalloprotease [General function prediction only]; Region: COG2321 1399115000555 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1399115000556 SnoaL-like domain; Region: SnoaL_2; pfam12680 1399115000557 Rrf2 family protein; Region: rrf2_super; TIGR00738 1399115000558 Transcriptional regulator; Region: Rrf2; pfam02082 1399115000559 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1399115000560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115000561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115000562 Walker A/P-loop; other site 1399115000563 ATP binding site [chemical binding]; other site 1399115000564 Q-loop/lid; other site 1399115000565 ABC transporter signature motif; other site 1399115000566 Walker B; other site 1399115000567 D-loop; other site 1399115000568 H-loop/switch region; other site 1399115000569 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1399115000570 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1399115000571 Walker A/P-loop; other site 1399115000572 ATP binding site [chemical binding]; other site 1399115000573 Q-loop/lid; other site 1399115000574 ABC transporter signature motif; other site 1399115000575 Walker B; other site 1399115000576 D-loop; other site 1399115000577 H-loop/switch region; other site 1399115000578 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1399115000579 Putative cyclase; Region: Cyclase; cl00814 1399115000580 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1399115000581 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1399115000582 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1399115000583 kynureninase; Region: kynureninase; TIGR01814 1399115000584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115000585 catalytic residue [active] 1399115000586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115000587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115000588 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1399115000589 Electron transfer DM13; Region: DM13; pfam10517 1399115000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115000591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115000592 putative substrate translocation pore; other site 1399115000593 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1399115000594 putative FMN binding site [chemical binding]; other site 1399115000595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115000596 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1399115000597 putative substrate translocation pore; other site 1399115000598 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1399115000599 HlyD family secretion protein; Region: HlyD_3; pfam13437 1399115000600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115000601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115000602 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115000603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115000604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115000605 metal binding site [ion binding]; metal-binding site 1399115000606 active site 1399115000607 I-site; other site 1399115000608 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115000609 MarR family; Region: MarR; pfam01047 1399115000610 MarR family; Region: MarR_2; cl17246 1399115000611 lysine transporter; Provisional; Region: PRK10836 1399115000612 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1399115000613 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1399115000614 SelR domain; Region: SelR; pfam01641 1399115000615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1399115000616 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1399115000617 amino acid transporter; Region: 2A0306; TIGR00909 1399115000618 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1399115000619 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1399115000620 putative oxidoreductase; Provisional; Region: PRK11579 1399115000621 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1399115000622 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1399115000623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115000624 NAD(P) binding site [chemical binding]; other site 1399115000625 active site 1399115000626 Staphylococcal nuclease homologues; Region: SNc; smart00318 1399115000627 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1399115000628 Catalytic site; other site 1399115000629 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1399115000630 Cation efflux family; Region: Cation_efflux; pfam01545 1399115000631 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1399115000632 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1399115000633 NAD binding site [chemical binding]; other site 1399115000634 homodimer interface [polypeptide binding]; other site 1399115000635 active site 1399115000636 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1399115000637 ABC1 family; Region: ABC1; cl17513 1399115000638 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1399115000639 Predicted membrane protein [Function unknown]; Region: COG2860 1399115000640 UPF0126 domain; Region: UPF0126; pfam03458 1399115000641 UPF0126 domain; Region: UPF0126; pfam03458 1399115000642 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1399115000643 putative heme peroxidase; Provisional; Region: PRK12276 1399115000644 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1399115000645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115000646 active site 1399115000647 xanthine permease; Region: pbuX; TIGR03173 1399115000648 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1399115000649 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1399115000650 active site residue [active] 1399115000651 Cache domain; Region: Cache_1; pfam02743 1399115000652 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1399115000653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115000654 dimerization interface [polypeptide binding]; other site 1399115000655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115000656 dimer interface [polypeptide binding]; other site 1399115000657 putative CheW interface [polypeptide binding]; other site 1399115000658 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115000659 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1399115000660 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1399115000661 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1399115000662 hypothetical protein; Provisional; Region: PRK13661 1399115000663 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115000664 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1399115000665 Walker A/P-loop; other site 1399115000666 ATP binding site [chemical binding]; other site 1399115000667 Q-loop/lid; other site 1399115000668 ABC transporter signature motif; other site 1399115000669 Walker B; other site 1399115000670 D-loop; other site 1399115000671 H-loop/switch region; other site 1399115000672 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1399115000673 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115000674 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1399115000675 Walker A/P-loop; other site 1399115000676 ATP binding site [chemical binding]; other site 1399115000677 Q-loop/lid; other site 1399115000678 ABC transporter signature motif; other site 1399115000679 Walker B; other site 1399115000680 D-loop; other site 1399115000681 H-loop/switch region; other site 1399115000682 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1399115000683 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1399115000684 Carbon starvation protein CstA; Region: CstA; pfam02554 1399115000685 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1399115000686 two-component response regulator; Provisional; Region: PRK14084 1399115000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115000688 active site 1399115000689 phosphorylation site [posttranslational modification] 1399115000690 intermolecular recognition site; other site 1399115000691 dimerization interface [polypeptide binding]; other site 1399115000692 LytTr DNA-binding domain; Region: LytTR; smart00850 1399115000693 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1399115000694 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115000695 GAF domain; Region: GAF; cl17456 1399115000696 Histidine kinase; Region: His_kinase; pfam06580 1399115000697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115000698 ATP binding site [chemical binding]; other site 1399115000699 Mg2+ binding site [ion binding]; other site 1399115000700 G-X-G motif; other site 1399115000701 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1399115000702 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1399115000703 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1399115000704 HD domain; Region: HD_3; cl17350 1399115000705 HD domain; Region: HD_3; cl17350 1399115000706 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1399115000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115000708 putative substrate translocation pore; other site 1399115000709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1399115000710 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1399115000711 prohibitin homologues; Region: PHB; smart00244 1399115000712 EDD domain protein, DegV family; Region: DegV; TIGR00762 1399115000713 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1399115000714 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1399115000715 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1399115000716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115000717 Zn2+ binding site [ion binding]; other site 1399115000718 Mg2+ binding site [ion binding]; other site 1399115000719 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115000720 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1399115000721 active site 1399115000722 substrate binding site [chemical binding]; other site 1399115000723 ATP binding site [chemical binding]; other site 1399115000724 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1399115000725 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1399115000726 Nucleoside recognition; Region: Gate; pfam07670 1399115000727 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1399115000728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115000729 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115000730 NAD(P) binding site [chemical binding]; other site 1399115000731 active site 1399115000732 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1399115000733 active site 1 [active] 1399115000734 dimer interface [polypeptide binding]; other site 1399115000735 hexamer interface [polypeptide binding]; other site 1399115000736 active site 2 [active] 1399115000737 YwhD family; Region: YwhD; pfam08741 1399115000738 phosphodiesterase YaeI; Provisional; Region: PRK11340 1399115000739 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1399115000740 putative active site [active] 1399115000741 putative metal binding site [ion binding]; other site 1399115000742 BCCT family transporter; Region: BCCT; pfam02028 1399115000743 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1399115000744 dimer interface [polypeptide binding]; other site 1399115000745 FMN binding site [chemical binding]; other site 1399115000746 spermidine synthase; Provisional; Region: PRK00811 1399115000747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115000748 agmatinase; Region: agmatinase; TIGR01230 1399115000749 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1399115000750 putative active site [active] 1399115000751 Mn binding site [ion binding]; other site 1399115000752 LysE type translocator; Region: LysE; cl00565 1399115000753 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1399115000754 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1399115000755 AsnC family; Region: AsnC_trans_reg; pfam01037 1399115000756 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1399115000757 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1399115000758 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1399115000759 active site 1399115000760 putative catalytic site [active] 1399115000761 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1399115000762 heme-binding site [chemical binding]; other site 1399115000763 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115000764 dimer interface [polypeptide binding]; other site 1399115000765 putative CheW interface [polypeptide binding]; other site 1399115000766 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1399115000767 metal-binding site [ion binding] 1399115000768 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1399115000769 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1399115000770 metal-binding site [ion binding] 1399115000771 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1399115000772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115000773 motif II; other site 1399115000774 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1399115000775 putative homodimer interface [polypeptide binding]; other site 1399115000776 putative homotetramer interface [polypeptide binding]; other site 1399115000777 putative allosteric switch controlling residues; other site 1399115000778 putative metal binding site [ion binding]; other site 1399115000779 putative homodimer-homodimer interface [polypeptide binding]; other site 1399115000780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115000781 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1399115000782 putative substrate translocation pore; other site 1399115000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115000784 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1399115000785 acetolactate synthase; Reviewed; Region: PRK08322 1399115000786 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1399115000787 PYR/PP interface [polypeptide binding]; other site 1399115000788 dimer interface [polypeptide binding]; other site 1399115000789 TPP binding site [chemical binding]; other site 1399115000790 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1399115000791 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1399115000792 TPP-binding site [chemical binding]; other site 1399115000793 succinic semialdehyde dehydrogenase; Region: PLN02278 1399115000794 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1399115000795 tetramerization interface [polypeptide binding]; other site 1399115000796 NAD(P) binding site [chemical binding]; other site 1399115000797 catalytic residues [active] 1399115000798 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1399115000799 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1399115000800 Ca binding site [ion binding]; other site 1399115000801 active site 1399115000802 catalytic site [active] 1399115000803 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1399115000804 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1399115000805 nudix motif; other site 1399115000806 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1399115000807 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1399115000808 dimer interface [polypeptide binding]; other site 1399115000809 active site 1399115000810 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1399115000811 4Fe-4S binding domain; Region: Fer4; cl02805 1399115000812 Cysteine-rich domain; Region: CCG; pfam02754 1399115000813 Cysteine-rich domain; Region: CCG; pfam02754 1399115000814 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1399115000815 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1399115000816 Domain of unknown function DUF21; Region: DUF21; pfam01595 1399115000817 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1399115000818 Transporter associated domain; Region: CorC_HlyC; smart01091 1399115000819 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115000820 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1399115000821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115000822 ATP binding site [chemical binding]; other site 1399115000823 Mg2+ binding site [ion binding]; other site 1399115000824 G-X-G motif; other site 1399115000825 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1399115000826 active site 1399115000827 catalytic residues [active] 1399115000828 EDD domain protein, DegV family; Region: DegV; TIGR00762 1399115000829 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1399115000830 CrcB-like protein; Region: CRCB; cl09114 1399115000831 CrcB-like protein; Region: CRCB; cl09114 1399115000832 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1399115000833 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115000834 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115000835 dimer interface [polypeptide binding]; other site 1399115000836 putative CheW interface [polypeptide binding]; other site 1399115000837 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115000838 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1399115000839 putative NAD(P) binding site [chemical binding]; other site 1399115000840 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1399115000841 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1399115000842 active site 1399115000843 NTP binding site [chemical binding]; other site 1399115000844 metal binding triad [ion binding]; metal-binding site 1399115000845 antibiotic binding site [chemical binding]; other site 1399115000846 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115000847 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115000848 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1399115000849 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1399115000850 putative metal binding site [ion binding]; other site 1399115000851 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1399115000852 active site 1399115000853 NIPSNAP; Region: NIPSNAP; pfam07978 1399115000854 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1399115000855 nudix motif; other site 1399115000856 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115000857 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1399115000858 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1399115000859 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1399115000860 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1399115000861 YtkA-like; Region: YtkA; pfam13115 1399115000862 membrane-attack complex/perforin (MACPF) Superfamily; Provisional; Region: PTZ00482 1399115000863 CopC domain; Region: CopC; pfam04234 1399115000864 Copper resistance protein D; Region: CopD; cl00563 1399115000865 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1399115000866 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1399115000867 catalytic triad [active] 1399115000868 catalytic triad [active] 1399115000869 oxyanion hole [active] 1399115000870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115000871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115000872 dimer interface [polypeptide binding]; other site 1399115000873 phosphorylation site [posttranslational modification] 1399115000874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115000875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115000876 active site 1399115000877 phosphorylation site [posttranslational modification] 1399115000878 intermolecular recognition site; other site 1399115000879 dimerization interface [polypeptide binding]; other site 1399115000880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115000881 DNA binding site [nucleotide binding] 1399115000882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115000883 S-adenosylmethionine binding site [chemical binding]; other site 1399115000884 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1399115000885 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1399115000886 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1399115000887 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1399115000888 DNA binding site [nucleotide binding] 1399115000889 active site 1399115000890 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1399115000891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115000892 AAA domain; Region: AAA_18; pfam13238 1399115000893 NUMOD4 motif; Region: NUMOD4; pfam07463 1399115000894 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115000895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115000896 dimer interface [polypeptide binding]; other site 1399115000897 putative CheW interface [polypeptide binding]; other site 1399115000898 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115000899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115000900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115000901 metal binding site [ion binding]; metal-binding site 1399115000902 active site 1399115000903 I-site; other site 1399115000904 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 1399115000905 nudix motif; other site 1399115000906 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1399115000907 catalytic triad [active] 1399115000908 active site nucleophile [active] 1399115000909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115000910 dimerization interface [polypeptide binding]; other site 1399115000911 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115000912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115000913 dimer interface [polypeptide binding]; other site 1399115000914 putative CheW interface [polypeptide binding]; other site 1399115000915 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1399115000916 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115000917 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115000918 Walker A/P-loop; other site 1399115000919 ATP binding site [chemical binding]; other site 1399115000920 Q-loop/lid; other site 1399115000921 ABC transporter signature motif; other site 1399115000922 Walker B; other site 1399115000923 D-loop; other site 1399115000924 H-loop/switch region; other site 1399115000925 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1399115000926 homotrimer interaction site [polypeptide binding]; other site 1399115000927 putative active site [active] 1399115000928 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1399115000929 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1399115000930 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1399115000931 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1399115000932 Ligand Binding Site [chemical binding]; other site 1399115000933 AAA domain; Region: AAA_11; pfam13086 1399115000934 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1399115000935 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1399115000936 AAA domain; Region: AAA_12; pfam13087 1399115000937 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1399115000938 putative active site [active] 1399115000939 hypothetical protein; Provisional; Region: PRK06761 1399115000940 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1399115000941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115000942 dimer interface [polypeptide binding]; other site 1399115000943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1399115000944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1399115000945 DNA binding site [nucleotide binding] 1399115000946 domain linker motif; other site 1399115000947 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1399115000948 dimerization interface [polypeptide binding]; other site 1399115000949 ligand binding site [chemical binding]; other site 1399115000950 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1399115000951 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1399115000952 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1399115000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115000954 ABC-ATPase subunit interface; other site 1399115000955 putative PBP binding loops; other site 1399115000956 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1399115000957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115000958 dimer interface [polypeptide binding]; other site 1399115000959 conserved gate region; other site 1399115000960 putative PBP binding loops; other site 1399115000961 ABC-ATPase subunit interface; other site 1399115000962 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1399115000963 beta-galactosidase; Region: BGL; TIGR03356 1399115000964 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1399115000965 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1399115000966 active site 1399115000967 catalytic residues [active] 1399115000968 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1399115000969 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1399115000970 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1399115000971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115000972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115000973 DNA binding residues [nucleotide binding] 1399115000974 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1399115000975 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1399115000976 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1399115000977 catalytic residues [active] 1399115000978 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1399115000979 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1399115000980 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 1399115000981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115000982 MarR family; Region: MarR_2; pfam12802 1399115000983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1399115000984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115000985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115000986 Walker A/P-loop; other site 1399115000987 ATP binding site [chemical binding]; other site 1399115000988 Q-loop/lid; other site 1399115000989 ABC transporter signature motif; other site 1399115000990 Walker B; other site 1399115000991 D-loop; other site 1399115000992 H-loop/switch region; other site 1399115000993 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1399115000994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115000995 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1399115000996 Walker A/P-loop; other site 1399115000997 ATP binding site [chemical binding]; other site 1399115000998 Q-loop/lid; other site 1399115000999 ABC transporter signature motif; other site 1399115001000 Walker B; other site 1399115001001 D-loop; other site 1399115001002 H-loop/switch region; other site 1399115001003 Conserved TM helix; Region: TM_helix; pfam05552 1399115001004 amino acid transporter; Region: 2A0306; TIGR00909 1399115001005 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1399115001006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115001007 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115001008 Coenzyme A binding pocket [chemical binding]; other site 1399115001009 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1399115001010 nudix motif; other site 1399115001011 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1399115001012 active site 1399115001013 dimer interface [polypeptide binding]; other site 1399115001014 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1399115001015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115001016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115001017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1399115001018 dimerization interface [polypeptide binding]; other site 1399115001019 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1399115001020 putative homodimer interface [polypeptide binding]; other site 1399115001021 putative homotetramer interface [polypeptide binding]; other site 1399115001022 putative metal binding site [ion binding]; other site 1399115001023 putative homodimer-homodimer interface [polypeptide binding]; other site 1399115001024 putative allosteric switch controlling residues; other site 1399115001025 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1399115001026 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1399115001027 active site residue [active] 1399115001028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1399115001029 active site residue [active] 1399115001030 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1399115001031 CPxP motif; other site 1399115001032 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1399115001033 active site residue [active] 1399115001034 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 1399115001035 active site residue [active] 1399115001036 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115001037 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1399115001038 CPxP motif; other site 1399115001039 Protein of unknown function DUF131; Region: DUF131; cl00892 1399115001040 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1399115001041 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1399115001042 SelR domain; Region: SelR; pfam01641 1399115001043 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1399115001044 active site 1399115001045 catalytic triad [active] 1399115001046 HAMP domain; Region: HAMP; pfam00672 1399115001047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115001048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115001049 dimer interface [polypeptide binding]; other site 1399115001050 phosphorylation site [posttranslational modification] 1399115001051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115001052 ATP binding site [chemical binding]; other site 1399115001053 Mg2+ binding site [ion binding]; other site 1399115001054 G-X-G motif; other site 1399115001055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115001056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115001057 metal binding site [ion binding]; metal-binding site 1399115001058 active site 1399115001059 I-site; other site 1399115001060 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1399115001061 Heat induced stress protein YflT; Region: YflT; pfam11181 1399115001062 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1399115001063 Ligand Binding Site [chemical binding]; other site 1399115001064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115001065 putative Zn2+ binding site [ion binding]; other site 1399115001066 putative DNA binding site [nucleotide binding]; other site 1399115001067 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1399115001068 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115001069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115001070 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1399115001071 putative DNA binding site [nucleotide binding]; other site 1399115001072 putative Zn2+ binding site [ion binding]; other site 1399115001073 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1399115001074 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1399115001075 nucleotide binding site [chemical binding]; other site 1399115001076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1399115001077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1399115001078 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1399115001079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115001080 dimer interface [polypeptide binding]; other site 1399115001081 conserved gate region; other site 1399115001082 putative PBP binding loops; other site 1399115001083 ABC-ATPase subunit interface; other site 1399115001084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1399115001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115001086 dimer interface [polypeptide binding]; other site 1399115001087 conserved gate region; other site 1399115001088 putative PBP binding loops; other site 1399115001089 ABC-ATPase subunit interface; other site 1399115001090 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1399115001091 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1399115001092 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1399115001093 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1399115001094 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1399115001095 Melibiase; Region: Melibiase; pfam02065 1399115001096 galactokinase; Provisional; Region: PRK05322 1399115001097 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1399115001098 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1399115001099 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1399115001100 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1399115001101 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1399115001102 NAD binding site [chemical binding]; other site 1399115001103 homodimer interface [polypeptide binding]; other site 1399115001104 active site 1399115001105 substrate binding site [chemical binding]; other site 1399115001106 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1399115001107 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1399115001108 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1399115001109 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1399115001110 active site 1399115001111 catalytic residues [active] 1399115001112 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1399115001113 active site 1399115001114 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1399115001115 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1399115001116 DNA binding site [nucleotide binding] 1399115001117 active site 1399115001118 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1399115001119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115001120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115001121 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115001122 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1399115001123 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1399115001124 E3 interaction surface; other site 1399115001125 lipoyl attachment site [posttranslational modification]; other site 1399115001126 e3 binding domain; Region: E3_binding; pfam02817 1399115001127 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1399115001128 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1399115001129 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1399115001130 alpha subunit interface [polypeptide binding]; other site 1399115001131 TPP binding site [chemical binding]; other site 1399115001132 heterodimer interface [polypeptide binding]; other site 1399115001133 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1399115001134 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1399115001135 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1399115001136 TPP-binding site [chemical binding]; other site 1399115001137 tetramer interface [polypeptide binding]; other site 1399115001138 heterodimer interface [polypeptide binding]; other site 1399115001139 phosphorylation loop region [posttranslational modification] 1399115001140 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1399115001141 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1399115001142 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1399115001143 NAD binding site [chemical binding]; other site 1399115001144 Phe binding site; other site 1399115001145 Predicted thioesterase [General function prediction only]; Region: COG5496 1399115001146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1399115001147 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1399115001148 acyl-activating enzyme (AAE) consensus motif; other site 1399115001149 AMP binding site [chemical binding]; other site 1399115001150 active site 1399115001151 CoA binding site [chemical binding]; other site 1399115001152 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1399115001153 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1399115001154 Phenylacetic acid degradation B; Region: PaaB; cl01371 1399115001155 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1399115001156 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1399115001157 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1399115001158 conserved hypothetical protein; Region: TIGR02118 1399115001159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1399115001160 enoyl-CoA hydratase; Provisional; Region: PRK05862 1399115001161 substrate binding site [chemical binding]; other site 1399115001162 oxyanion hole (OAH) forming residues; other site 1399115001163 trimer interface [polypeptide binding]; other site 1399115001164 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1399115001165 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1399115001166 NAD(P) binding site [chemical binding]; other site 1399115001167 catalytic residues [active] 1399115001168 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1399115001169 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1399115001170 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1399115001171 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1399115001172 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1399115001173 dimer interface [polypeptide binding]; other site 1399115001174 active site 1399115001175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1399115001176 enoyl-CoA hydratase; Provisional; Region: PRK07657 1399115001177 substrate binding site [chemical binding]; other site 1399115001178 oxyanion hole (OAH) forming residues; other site 1399115001179 trimer interface [polypeptide binding]; other site 1399115001180 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1399115001181 PaaX-like protein; Region: PaaX; pfam07848 1399115001182 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1399115001183 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1399115001184 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1399115001185 trimer interface [polypeptide binding]; other site 1399115001186 putative metal binding site [ion binding]; other site 1399115001187 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1399115001188 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1399115001189 FMN binding site [chemical binding]; other site 1399115001190 substrate binding site [chemical binding]; other site 1399115001191 putative catalytic residue [active] 1399115001192 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115001193 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1399115001194 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1399115001195 ligand binding site [chemical binding]; other site 1399115001196 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1399115001197 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115001198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115001199 putative substrate translocation pore; other site 1399115001200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115001201 dimerization interface [polypeptide binding]; other site 1399115001202 putative DNA binding site [nucleotide binding]; other site 1399115001203 putative Zn2+ binding site [ion binding]; other site 1399115001204 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1399115001205 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1399115001206 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1399115001207 metal binding site [ion binding]; metal-binding site 1399115001208 dimer interface [polypeptide binding]; other site 1399115001209 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1399115001210 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115001211 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1399115001212 NlpC/P60 family; Region: NLPC_P60; pfam00877 1399115001213 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115001214 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115001215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115001216 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1399115001217 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1399115001218 Heat induced stress protein YflT; Region: YflT; pfam11181 1399115001219 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115001220 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115001221 active site 1399115001222 catalytic tetrad [active] 1399115001223 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1399115001224 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1399115001225 putative active site [active] 1399115001226 metal binding site [ion binding]; metal-binding site 1399115001227 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115001228 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1399115001229 Repair protein; Region: Repair_PSII; pfam04536 1399115001230 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1399115001231 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1399115001232 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1399115001233 YolD-like protein; Region: YolD; pfam08863 1399115001234 DNA polymerase IV; Reviewed; Region: PRK03103 1399115001235 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1399115001236 active site 1399115001237 DNA binding site [nucleotide binding] 1399115001238 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1399115001239 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1399115001240 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1399115001241 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1399115001242 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1399115001243 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1399115001244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115001245 Coenzyme A binding pocket [chemical binding]; other site 1399115001246 ARD/ARD' family; Region: ARD; pfam03079 1399115001247 Cupin domain; Region: Cupin_2; pfam07883 1399115001248 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1399115001249 intersubunit interface [polypeptide binding]; other site 1399115001250 active site 1399115001251 Zn2+ binding site [ion binding]; other site 1399115001252 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1399115001253 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1399115001254 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1399115001255 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1399115001256 dimer interface [polypeptide binding]; other site 1399115001257 active site 1399115001258 catalytic residue [active] 1399115001259 metal binding site [ion binding]; metal-binding site 1399115001260 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1399115001261 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115001262 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1399115001263 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1399115001264 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1399115001265 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1399115001266 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1399115001267 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1399115001268 Walker A/P-loop; other site 1399115001269 ATP binding site [chemical binding]; other site 1399115001270 Q-loop/lid; other site 1399115001271 ABC transporter signature motif; other site 1399115001272 Walker B; other site 1399115001273 D-loop; other site 1399115001274 H-loop/switch region; other site 1399115001275 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1399115001276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1399115001277 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1399115001278 TM-ABC transporter signature motif; other site 1399115001279 MoxR-like ATPases [General function prediction only]; Region: COG0714 1399115001280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115001281 Walker A motif; other site 1399115001282 ATP binding site [chemical binding]; other site 1399115001283 Walker B motif; other site 1399115001284 arginine finger; other site 1399115001285 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1399115001286 Protein of unknown function DUF58; Region: DUF58; pfam01882 1399115001287 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1399115001288 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1399115001289 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1399115001290 GMP synthase; Reviewed; Region: guaA; PRK00074 1399115001291 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1399115001292 AMP/PPi binding site [chemical binding]; other site 1399115001293 candidate oxyanion hole; other site 1399115001294 catalytic triad [active] 1399115001295 potential glutamine specificity residues [chemical binding]; other site 1399115001296 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1399115001297 ATP Binding subdomain [chemical binding]; other site 1399115001298 Ligand Binding sites [chemical binding]; other site 1399115001299 Dimerization subdomain; other site 1399115001300 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1399115001301 active site 1399115001302 DNA binding site [nucleotide binding] 1399115001303 Int/Topo IB signature motif; other site 1399115001304 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1399115001305 GIY-YIG motif/motif A; other site 1399115001306 active site 1399115001307 catalytic site [active] 1399115001308 Domain of unknown function (DUF1886); Region: DUF1886; cl01666 1399115001309 Abortive infection C-terminus; Region: Abi_C; pfam14355 1399115001310 DNA methylase; Region: N6_N4_Mtase; cl17433 1399115001311 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 1399115001312 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1399115001313 Proline dehydrogenase; Region: Pro_dh; cl03282 1399115001314 NETI protein; Region: NETI; pfam14044 1399115001315 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1399115001316 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1399115001317 ATP-grasp domain; Region: ATP-grasp; pfam02222 1399115001318 adenylosuccinate lyase; Provisional; Region: PRK07492 1399115001319 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1399115001320 tetramer interface [polypeptide binding]; other site 1399115001321 active site 1399115001322 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 1399115001323 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1399115001324 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1399115001325 ATP binding site [chemical binding]; other site 1399115001326 active site 1399115001327 substrate binding site [chemical binding]; other site 1399115001328 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1399115001329 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1399115001330 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1399115001331 putative active site [active] 1399115001332 catalytic triad [active] 1399115001333 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1399115001334 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1399115001335 dimerization interface [polypeptide binding]; other site 1399115001336 ATP binding site [chemical binding]; other site 1399115001337 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1399115001338 dimerization interface [polypeptide binding]; other site 1399115001339 ATP binding site [chemical binding]; other site 1399115001340 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1399115001341 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1399115001342 active site 1399115001343 tetramer interface [polypeptide binding]; other site 1399115001344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115001345 active site 1399115001346 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1399115001347 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1399115001348 dimerization interface [polypeptide binding]; other site 1399115001349 putative ATP binding site [chemical binding]; other site 1399115001350 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1399115001351 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1399115001352 active site 1399115001353 substrate binding site [chemical binding]; other site 1399115001354 cosubstrate binding site; other site 1399115001355 catalytic site [active] 1399115001356 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1399115001357 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1399115001358 purine monophosphate binding site [chemical binding]; other site 1399115001359 dimer interface [polypeptide binding]; other site 1399115001360 putative catalytic residues [active] 1399115001361 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1399115001362 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1399115001363 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1399115001364 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1399115001365 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1399115001366 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1399115001367 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1399115001368 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1399115001369 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1399115001370 active site 1399115001371 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1399115001372 Trp repressor protein; Region: Trp_repressor; cl17266 1399115001373 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1399115001374 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1399115001375 PcrB family; Region: PcrB; pfam01884 1399115001376 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1399115001377 substrate binding site [chemical binding]; other site 1399115001378 putative active site [active] 1399115001379 dimer interface [polypeptide binding]; other site 1399115001380 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1399115001381 Part of AAA domain; Region: AAA_19; pfam13245 1399115001382 Family description; Region: UvrD_C_2; pfam13538 1399115001383 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1399115001384 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1399115001385 nucleotide binding pocket [chemical binding]; other site 1399115001386 K-X-D-G motif; other site 1399115001387 catalytic site [active] 1399115001388 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1399115001389 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1399115001390 Helix-hairpin-helix motif; Region: HHH; pfam00633 1399115001391 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1399115001392 Dimer interface [polypeptide binding]; other site 1399115001393 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1399115001394 active site 1399115001395 catalytic site [active] 1399115001396 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1399115001397 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1399115001398 putative dimer interface [polypeptide binding]; other site 1399115001399 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1399115001400 putative dimer interface [polypeptide binding]; other site 1399115001401 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1399115001402 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1399115001403 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1399115001404 putative active site [active] 1399115001405 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1399115001406 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1399115001407 metal binding site [ion binding]; metal-binding site 1399115001408 dimer interface [polypeptide binding]; other site 1399115001409 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1399115001410 chaperone protein DnaJ; Provisional; Region: PRK14299 1399115001411 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1399115001412 HSP70 interaction site [polypeptide binding]; other site 1399115001413 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1399115001414 dimer interface [polypeptide binding]; other site 1399115001415 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1399115001416 Clp amino terminal domain; Region: Clp_N; pfam02861 1399115001417 Clp amino terminal domain; Region: Clp_N; pfam02861 1399115001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115001419 Walker A motif; other site 1399115001420 ATP binding site [chemical binding]; other site 1399115001421 Walker B motif; other site 1399115001422 arginine finger; other site 1399115001423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115001424 Walker A motif; other site 1399115001425 ATP binding site [chemical binding]; other site 1399115001426 Walker B motif; other site 1399115001427 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1399115001428 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1399115001429 glutaminase A; Region: Gln_ase; TIGR03814 1399115001430 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1399115001431 multidrug efflux protein; Reviewed; Region: PRK01766 1399115001432 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1399115001433 cation binding site [ion binding]; other site 1399115001434 Predicted integral membrane protein [Function unknown]; Region: COG0392 1399115001435 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1399115001436 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1399115001437 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1399115001438 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1399115001439 active site 1399115001440 dimer interface [polypeptide binding]; other site 1399115001441 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1399115001442 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1399115001443 active site 1399115001444 trimer interface [polypeptide binding]; other site 1399115001445 allosteric site; other site 1399115001446 active site lid [active] 1399115001447 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1399115001448 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1399115001449 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1399115001450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115001451 DNA-binding site [nucleotide binding]; DNA binding site 1399115001452 UTRA domain; Region: UTRA; pfam07702 1399115001453 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1399115001454 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1399115001455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115001456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1399115001457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115001458 Coenzyme A binding pocket [chemical binding]; other site 1399115001459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115001460 argininosuccinate synthase; Provisional; Region: PRK13820 1399115001461 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1399115001462 ANP binding site [chemical binding]; other site 1399115001463 Substrate Binding Site II [chemical binding]; other site 1399115001464 Substrate Binding Site I [chemical binding]; other site 1399115001465 argininosuccinate lyase; Provisional; Region: PRK00855 1399115001466 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1399115001467 active sites [active] 1399115001468 tetramer interface [polypeptide binding]; other site 1399115001469 aspartate kinase; Reviewed; Region: PRK06635 1399115001470 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1399115001471 putative nucleotide binding site [chemical binding]; other site 1399115001472 putative catalytic residues [active] 1399115001473 putative Mg ion binding site [ion binding]; other site 1399115001474 putative aspartate binding site [chemical binding]; other site 1399115001475 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1399115001476 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1399115001477 putative allosteric regulatory residue; other site 1399115001478 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1399115001479 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1399115001480 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1399115001481 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1399115001482 dimer interface [polypeptide binding]; other site 1399115001483 active site 1399115001484 catalytic residue [active] 1399115001485 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1399115001486 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1399115001487 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1399115001488 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1399115001489 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1399115001490 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1399115001491 trimer interface [polypeptide binding]; other site 1399115001492 active site 1399115001493 substrate binding site [chemical binding]; other site 1399115001494 CoA binding site [chemical binding]; other site 1399115001495 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1399115001496 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1399115001497 homodimer interface [polypeptide binding]; other site 1399115001498 substrate-cofactor binding pocket; other site 1399115001499 catalytic residue [active] 1399115001500 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1399115001501 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1399115001502 active site 1399115001503 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1399115001504 dimer interface [polypeptide binding]; other site 1399115001505 substrate binding site [chemical binding]; other site 1399115001506 catalytic residues [active] 1399115001507 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1399115001508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1399115001509 active site 1399115001510 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1399115001511 substrate binding site [chemical binding]; other site 1399115001512 catalytic residues [active] 1399115001513 dimer interface [polypeptide binding]; other site 1399115001514 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1399115001515 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1399115001516 NodB motif; other site 1399115001517 active site 1399115001518 catalytic site [active] 1399115001519 metal binding site [ion binding]; metal-binding site 1399115001520 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1399115001521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1399115001522 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1399115001523 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1399115001524 Walker A/P-loop; other site 1399115001525 ATP binding site [chemical binding]; other site 1399115001526 Q-loop/lid; other site 1399115001527 ABC transporter signature motif; other site 1399115001528 Walker B; other site 1399115001529 D-loop; other site 1399115001530 H-loop/switch region; other site 1399115001531 FOG: CBS domain [General function prediction only]; Region: COG0517 1399115001532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1399115001533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115001534 dimer interface [polypeptide binding]; other site 1399115001535 conserved gate region; other site 1399115001536 putative PBP binding loops; other site 1399115001537 ABC-ATPase subunit interface; other site 1399115001538 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1399115001539 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1399115001540 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1399115001541 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1399115001542 trimer interface [polypeptide binding]; other site 1399115001543 putative metal binding site [ion binding]; other site 1399115001544 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1399115001545 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1399115001546 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1399115001547 active site 1399115001548 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1399115001549 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1399115001550 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1399115001551 peptide binding site [polypeptide binding]; other site 1399115001552 MgtC family; Region: MgtC; pfam02308 1399115001553 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1399115001554 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1399115001555 Spore germination protein; Region: Spore_permease; cl17796 1399115001556 PAS fold; Region: PAS; pfam00989 1399115001557 PAS domain; Region: PAS_9; pfam13426 1399115001558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115001559 putative active site [active] 1399115001560 heme pocket [chemical binding]; other site 1399115001561 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115001562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115001563 metal binding site [ion binding]; metal-binding site 1399115001564 active site 1399115001565 I-site; other site 1399115001566 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115001567 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1399115001568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1399115001569 inhibitor-cofactor binding pocket; inhibition site 1399115001570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115001571 catalytic residue [active] 1399115001572 CsbD-like; Region: CsbD; pfam05532 1399115001573 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1399115001574 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115001575 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115001576 active site turn [active] 1399115001577 phosphorylation site [posttranslational modification] 1399115001578 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1399115001579 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1399115001580 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1399115001581 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1399115001582 NodB motif; other site 1399115001583 active site 1399115001584 catalytic site [active] 1399115001585 Zn binding site [ion binding]; other site 1399115001586 YhfH-like protein; Region: YhfH; pfam14149 1399115001587 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1399115001588 dimer interface [polypeptide binding]; other site 1399115001589 FMN binding site [chemical binding]; other site 1399115001590 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1399115001591 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1399115001592 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1399115001593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115001594 dimerization interface [polypeptide binding]; other site 1399115001595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115001596 dimer interface [polypeptide binding]; other site 1399115001597 phosphorylation site [posttranslational modification] 1399115001598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115001599 ATP binding site [chemical binding]; other site 1399115001600 Mg2+ binding site [ion binding]; other site 1399115001601 G-X-G motif; other site 1399115001602 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115001603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115001604 active site 1399115001605 phosphorylation site [posttranslational modification] 1399115001606 intermolecular recognition site; other site 1399115001607 dimerization interface [polypeptide binding]; other site 1399115001608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115001609 DNA binding site [nucleotide binding] 1399115001610 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1399115001611 catalytic core [active] 1399115001612 phytoene desaturase; Region: crtI_fam; TIGR02734 1399115001613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115001614 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1399115001615 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115001616 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1399115001617 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1399115001618 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1399115001619 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1399115001620 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1399115001621 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1399115001622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1399115001623 active site 1399115001624 metal binding site [ion binding]; metal-binding site 1399115001625 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1399115001626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115001627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115001628 Predicted membrane protein [Function unknown]; Region: COG1511 1399115001629 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1399115001630 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1399115001631 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1399115001632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115001633 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1399115001634 NADP binding site [chemical binding]; other site 1399115001635 dimer interface [polypeptide binding]; other site 1399115001636 Haemolytic domain; Region: Haemolytic; pfam01809 1399115001637 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1399115001638 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1399115001639 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1399115001640 NAD(P) binding site [chemical binding]; other site 1399115001641 catalytic residues [active] 1399115001642 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1399115001643 Predicted membrane protein [Function unknown]; Region: COG4325 1399115001644 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1399115001645 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1399115001646 Domain of unknown function DUF21; Region: DUF21; pfam01595 1399115001647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1399115001648 Transporter associated domain; Region: CorC_HlyC; smart01091 1399115001649 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1399115001650 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1399115001651 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1399115001652 proposed catalytic triad [active] 1399115001653 conserved cys residue [active] 1399115001654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115001655 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1399115001656 dimer interface [polypeptide binding]; other site 1399115001657 substrate binding site [chemical binding]; other site 1399115001658 metal binding site [ion binding]; metal-binding site 1399115001659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1399115001660 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115001661 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115001662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1399115001663 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115001664 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115001665 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1399115001666 dimer interface [polypeptide binding]; other site 1399115001667 substrate binding site [chemical binding]; other site 1399115001668 ATP binding site [chemical binding]; other site 1399115001669 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1399115001670 substrate binding site [chemical binding]; other site 1399115001671 multimerization interface [polypeptide binding]; other site 1399115001672 ATP binding site [chemical binding]; other site 1399115001673 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1399115001674 thiamine phosphate binding site [chemical binding]; other site 1399115001675 active site 1399115001676 pyrophosphate binding site [ion binding]; other site 1399115001677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115001678 dimerization interface [polypeptide binding]; other site 1399115001679 putative DNA binding site [nucleotide binding]; other site 1399115001680 putative Zn2+ binding site [ion binding]; other site 1399115001681 CHASE3 domain; Region: CHASE3; cl05000 1399115001682 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115001683 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115001684 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115001685 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1399115001686 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1399115001687 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1399115001688 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1399115001689 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1399115001690 FAD binding domain; Region: FAD_binding_4; pfam01565 1399115001691 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1399115001692 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115001693 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115001694 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115001695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115001696 Coenzyme A binding pocket [chemical binding]; other site 1399115001697 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1399115001698 dimer interface [polypeptide binding]; other site 1399115001699 FMN binding site [chemical binding]; other site 1399115001700 NADPH bind site [chemical binding]; other site 1399115001701 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1399115001702 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1399115001703 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115001704 NAD(P) binding site [chemical binding]; other site 1399115001705 putative active site [active] 1399115001706 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1399115001707 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1399115001708 catalytic residues [active] 1399115001709 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1399115001710 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1399115001711 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1399115001712 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1399115001713 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1399115001714 heterotetramer interface [polypeptide binding]; other site 1399115001715 active site pocket [active] 1399115001716 cleavage site 1399115001717 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1399115001718 nucleotide binding site [chemical binding]; other site 1399115001719 N-acetyl-L-glutamate binding site [chemical binding]; other site 1399115001720 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1399115001721 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1399115001722 inhibitor-cofactor binding pocket; inhibition site 1399115001723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115001724 catalytic residue [active] 1399115001725 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1399115001726 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1399115001727 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1399115001728 catalytic site [active] 1399115001729 subunit interface [polypeptide binding]; other site 1399115001730 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1399115001731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1399115001732 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115001733 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1399115001734 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1399115001735 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115001736 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1399115001737 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1399115001738 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1399115001739 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115001740 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1399115001741 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1399115001742 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1399115001743 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1399115001744 Potassium binding sites [ion binding]; other site 1399115001745 Cesium cation binding sites [ion binding]; other site 1399115001746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115001747 dimer interface [polypeptide binding]; other site 1399115001748 conserved gate region; other site 1399115001749 putative PBP binding loops; other site 1399115001750 ABC-ATPase subunit interface; other site 1399115001751 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1399115001752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115001753 dimer interface [polypeptide binding]; other site 1399115001754 conserved gate region; other site 1399115001755 putative PBP binding loops; other site 1399115001756 ABC-ATPase subunit interface; other site 1399115001757 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115001758 asparagine synthetase AsnA; Provisional; Region: PRK05425 1399115001759 motif 1; other site 1399115001760 dimer interface [polypeptide binding]; other site 1399115001761 active site 1399115001762 motif 2; other site 1399115001763 motif 3; other site 1399115001764 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1399115001765 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115001766 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1399115001767 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1399115001768 TrkA-C domain; Region: TrkA_C; pfam02080 1399115001769 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1399115001770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1399115001771 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1399115001772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115001773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115001774 dimerization interface [polypeptide binding]; other site 1399115001775 Histidine kinase; Region: His_kinase; pfam06580 1399115001776 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1399115001777 Response regulator receiver domain; Region: Response_reg; pfam00072 1399115001778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115001779 active site 1399115001780 phosphorylation site [posttranslational modification] 1399115001781 intermolecular recognition site; other site 1399115001782 dimerization interface [polypeptide binding]; other site 1399115001783 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1399115001784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1399115001785 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1399115001786 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1399115001787 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1399115001788 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1399115001789 NAD(P) binding site [chemical binding]; other site 1399115001790 catalytic residues [active] 1399115001791 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1399115001792 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1399115001793 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1399115001794 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1399115001795 active site 1399115001796 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1399115001797 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1399115001798 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1399115001799 ligand binding site [chemical binding]; other site 1399115001800 flexible hinge region; other site 1399115001801 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1399115001802 putative switch regulator; other site 1399115001803 non-specific DNA interactions [nucleotide binding]; other site 1399115001804 DNA binding site [nucleotide binding] 1399115001805 sequence specific DNA binding site [nucleotide binding]; other site 1399115001806 putative cAMP binding site [chemical binding]; other site 1399115001807 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1399115001808 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1399115001809 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 1399115001810 Putative D-pathway homolog; other site 1399115001811 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1399115001812 Low-spin heme binding site [chemical binding]; other site 1399115001813 Subunit I/II interface [polypeptide binding]; other site 1399115001814 Putative Q-pathway; other site 1399115001815 Putative alternate electron transfer pathway; other site 1399115001816 Putative water exit pathway; other site 1399115001817 Binuclear center (active site) [active] 1399115001818 Putative K-pathway homolog; other site 1399115001819 Putative proton exit pathway; other site 1399115001820 Subunit I/IIa interface [polypeptide binding]; other site 1399115001821 Electron transfer pathway; other site 1399115001822 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1399115001823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115001824 active site 1399115001825 phosphorylation site [posttranslational modification] 1399115001826 intermolecular recognition site; other site 1399115001827 dimerization interface [polypeptide binding]; other site 1399115001828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1399115001829 DNA binding residues [nucleotide binding] 1399115001830 dimerization interface [polypeptide binding]; other site 1399115001831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1399115001832 Histidine kinase; Region: HisKA_3; pfam07730 1399115001833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115001834 ATP binding site [chemical binding]; other site 1399115001835 Mg2+ binding site [ion binding]; other site 1399115001836 G-X-G motif; other site 1399115001837 Predicted membrane protein [Function unknown]; Region: COG4758 1399115001838 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1399115001839 GTPase RsgA; Reviewed; Region: PRK01889 1399115001840 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1399115001841 RNA binding site [nucleotide binding]; other site 1399115001842 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1399115001843 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1399115001844 GTP/Mg2+ binding site [chemical binding]; other site 1399115001845 G4 box; other site 1399115001846 G5 box; other site 1399115001847 G1 box; other site 1399115001848 Switch I region; other site 1399115001849 G2 box; other site 1399115001850 G3 box; other site 1399115001851 Switch II region; other site 1399115001852 Ethylene insensitive 3; Region: EIN3; cl04813 1399115001853 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1399115001854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115001855 Walker A/P-loop; other site 1399115001856 ATP binding site [chemical binding]; other site 1399115001857 Q-loop/lid; other site 1399115001858 ABC transporter signature motif; other site 1399115001859 Walker B; other site 1399115001860 D-loop; other site 1399115001861 H-loop/switch region; other site 1399115001862 ABC transporter; Region: ABC_tran_2; pfam12848 1399115001863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115001864 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1399115001865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115001866 FeS/SAM binding site; other site 1399115001867 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1399115001868 Pyruvate formate lyase 1; Region: PFL1; cd01678 1399115001869 coenzyme A binding site [chemical binding]; other site 1399115001870 active site 1399115001871 catalytic residues [active] 1399115001872 glycine loop; other site 1399115001873 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1399115001874 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1399115001875 ATP binding site [chemical binding]; other site 1399115001876 Mg++ binding site [ion binding]; other site 1399115001877 motif III; other site 1399115001878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115001879 nucleotide binding region [chemical binding]; other site 1399115001880 ATP-binding site [chemical binding]; other site 1399115001881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115001882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115001883 metal binding site [ion binding]; metal-binding site 1399115001884 active site 1399115001885 I-site; other site 1399115001886 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115001887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115001888 metal binding site [ion binding]; metal-binding site 1399115001889 active site 1399115001890 I-site; other site 1399115001891 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1399115001892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115001893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115001894 ABC transporter; Region: ABC_tran_2; pfam12848 1399115001895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115001896 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1399115001897 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1399115001898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1399115001899 putative acyl-acceptor binding pocket; other site 1399115001900 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1399115001901 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1399115001902 S1 domain; Region: S1_2; pfam13509 1399115001903 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1399115001904 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1399115001905 ATP binding site [chemical binding]; other site 1399115001906 Mg++ binding site [ion binding]; other site 1399115001907 motif III; other site 1399115001908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115001909 nucleotide binding region [chemical binding]; other site 1399115001910 ATP-binding site [chemical binding]; other site 1399115001911 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115001912 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1399115001913 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1399115001914 active site 1399115001915 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1399115001916 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1399115001917 metal binding site [ion binding]; metal-binding site 1399115001918 substrate binding pocket [chemical binding]; other site 1399115001919 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1399115001920 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1399115001921 acyl-activating enzyme (AAE) consensus motif; other site 1399115001922 putative AMP binding site [chemical binding]; other site 1399115001923 putative active site [active] 1399115001924 putative CoA binding site [chemical binding]; other site 1399115001925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1399115001926 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1399115001927 substrate binding site [chemical binding]; other site 1399115001928 oxyanion hole (OAH) forming residues; other site 1399115001929 trimer interface [polypeptide binding]; other site 1399115001930 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1399115001931 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1399115001932 dimer interface [polypeptide binding]; other site 1399115001933 tetramer interface [polypeptide binding]; other site 1399115001934 PYR/PP interface [polypeptide binding]; other site 1399115001935 TPP binding site [chemical binding]; other site 1399115001936 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1399115001937 TPP-binding site; other site 1399115001938 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1399115001939 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1399115001940 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1399115001941 UbiA prenyltransferase family; Region: UbiA; pfam01040 1399115001942 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1399115001943 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1399115001944 substrate binding site [chemical binding]; other site 1399115001945 ATP binding site [chemical binding]; other site 1399115001946 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 1399115001947 nudix motif; other site 1399115001948 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1399115001949 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1399115001950 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1399115001951 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1399115001952 EamA-like transporter family; Region: EamA; pfam00892 1399115001953 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115001954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115001955 putative substrate translocation pore; other site 1399115001956 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1399115001957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115001958 FeS/SAM binding site; other site 1399115001959 YfkB-like domain; Region: YfkB; pfam08756 1399115001960 TRAM domain; Region: TRAM; pfam01938 1399115001961 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1399115001962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115001963 S-adenosylmethionine binding site [chemical binding]; other site 1399115001964 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115001965 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115001966 active site 1399115001967 catalytic tetrad [active] 1399115001968 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1399115001969 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115001970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115001971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115001972 dimerization interface [polypeptide binding]; other site 1399115001973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115001974 dimer interface [polypeptide binding]; other site 1399115001975 phosphorylation site [posttranslational modification] 1399115001976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115001977 ATP binding site [chemical binding]; other site 1399115001978 Mg2+ binding site [ion binding]; other site 1399115001979 G-X-G motif; other site 1399115001980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115001981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115001982 active site 1399115001983 phosphorylation site [posttranslational modification] 1399115001984 intermolecular recognition site; other site 1399115001985 dimerization interface [polypeptide binding]; other site 1399115001986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115001987 DNA binding site [nucleotide binding] 1399115001988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115001989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115001990 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1399115001991 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1399115001992 active site 1399115001993 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1399115001994 TIGR01777 family protein; Region: yfcH 1399115001995 putative NAD(P) binding site [chemical binding]; other site 1399115001996 putative active site [active] 1399115001997 RecX family; Region: RecX; cl00936 1399115001998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115001999 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1399115002000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115002001 Walker A/P-loop; other site 1399115002002 ATP binding site [chemical binding]; other site 1399115002003 Q-loop/lid; other site 1399115002004 ABC transporter signature motif; other site 1399115002005 Walker B; other site 1399115002006 D-loop; other site 1399115002007 H-loop/switch region; other site 1399115002008 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115002009 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1399115002010 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115002011 Walker A/P-loop; other site 1399115002012 ATP binding site [chemical binding]; other site 1399115002013 Q-loop/lid; other site 1399115002014 ABC transporter signature motif; other site 1399115002015 Walker B; other site 1399115002016 D-loop; other site 1399115002017 H-loop/switch region; other site 1399115002018 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1399115002019 WVELL protein; Region: WVELL; pfam14043 1399115002020 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1399115002021 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 1399115002022 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1399115002023 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1399115002024 minor groove reading motif; other site 1399115002025 helix-hairpin-helix signature motif; other site 1399115002026 substrate binding pocket [chemical binding]; other site 1399115002027 active site 1399115002028 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1399115002029 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1399115002030 DNA binding and oxoG recognition site [nucleotide binding] 1399115002031 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1399115002032 hydrophobic ligand binding site; other site 1399115002033 hypothetical protein; Provisional; Region: PRK13662 1399115002034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1399115002035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115002036 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1399115002037 Walker A/P-loop; other site 1399115002038 ATP binding site [chemical binding]; other site 1399115002039 Q-loop/lid; other site 1399115002040 ABC transporter signature motif; other site 1399115002041 Walker B; other site 1399115002042 D-loop; other site 1399115002043 H-loop/switch region; other site 1399115002044 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1399115002045 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1399115002046 inhibitor-cofactor binding pocket; inhibition site 1399115002047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115002048 catalytic residue [active] 1399115002049 ferric uptake regulator; Provisional; Region: fur; PRK09462 1399115002050 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1399115002051 metal binding site 2 [ion binding]; metal-binding site 1399115002052 putative DNA binding helix; other site 1399115002053 metal binding site 1 [ion binding]; metal-binding site 1399115002054 dimer interface [polypeptide binding]; other site 1399115002055 structural Zn2+ binding site [ion binding]; other site 1399115002056 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1399115002057 epoxyqueuosine reductase; Region: TIGR00276 1399115002058 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1399115002059 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1399115002060 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1399115002061 DNA binding site [nucleotide binding] 1399115002062 active site 1399115002063 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1399115002064 Transglycosylase; Region: Transgly; pfam00912 1399115002065 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1399115002066 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1399115002067 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1399115002068 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1399115002069 ligand binding site; other site 1399115002070 oligomer interface; other site 1399115002071 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1399115002072 dimer interface [polypeptide binding]; other site 1399115002073 N-terminal domain interface [polypeptide binding]; other site 1399115002074 sulfate 1 binding site; other site 1399115002075 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1399115002076 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1399115002077 ligand binding site; other site 1399115002078 oligomer interface; other site 1399115002079 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1399115002080 dimer interface [polypeptide binding]; other site 1399115002081 N-terminal domain interface [polypeptide binding]; other site 1399115002082 sulfate 1 binding site; other site 1399115002083 glycogen synthase; Provisional; Region: glgA; PRK00654 1399115002084 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1399115002085 ADP-binding pocket [chemical binding]; other site 1399115002086 homodimer interface [polypeptide binding]; other site 1399115002087 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1399115002088 homodimer interface [polypeptide binding]; other site 1399115002089 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1399115002090 active site pocket [active] 1399115002091 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1399115002092 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1399115002093 active site residue [active] 1399115002094 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1399115002095 active site residue [active] 1399115002096 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1399115002097 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1399115002098 active site 1399115002099 substrate binding site [chemical binding]; other site 1399115002100 metal binding site [ion binding]; metal-binding site 1399115002101 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115002102 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115002103 active site 1399115002104 catalytic tetrad [active] 1399115002105 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1399115002106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115002107 dimer interface [polypeptide binding]; other site 1399115002108 conserved gate region; other site 1399115002109 putative PBP binding loops; other site 1399115002110 ABC-ATPase subunit interface; other site 1399115002111 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1399115002112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1399115002113 substrate binding pocket [chemical binding]; other site 1399115002114 membrane-bound complex binding site; other site 1399115002115 hinge residues; other site 1399115002116 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1399115002117 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1399115002118 Walker A/P-loop; other site 1399115002119 ATP binding site [chemical binding]; other site 1399115002120 Q-loop/lid; other site 1399115002121 ABC transporter signature motif; other site 1399115002122 Walker B; other site 1399115002123 D-loop; other site 1399115002124 H-loop/switch region; other site 1399115002125 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 1399115002126 active site 1399115002127 homotetramer interface [polypeptide binding]; other site 1399115002128 TOBE domain; Region: TOBE; pfam03459 1399115002129 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1399115002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1399115002131 hypothetical protein; Provisional; Region: PRK13676 1399115002132 YhzD-like protein; Region: YhzD; pfam14120 1399115002133 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1399115002134 active site 1399115002135 DNA polymerase IV; Validated; Region: PRK02406 1399115002136 DNA binding site [nucleotide binding] 1399115002137 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1399115002138 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1399115002139 Cl binding site [ion binding]; other site 1399115002140 oligomer interface [polypeptide binding]; other site 1399115002141 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1399115002142 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1399115002143 generic binding surface II; other site 1399115002144 generic binding surface I; other site 1399115002145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115002146 Zn2+ binding site [ion binding]; other site 1399115002147 Mg2+ binding site [ion binding]; other site 1399115002148 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1399115002149 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1399115002150 active site 1399115002151 FMN binding site [chemical binding]; other site 1399115002152 substrate binding site [chemical binding]; other site 1399115002153 homotetramer interface [polypeptide binding]; other site 1399115002154 catalytic residue [active] 1399115002155 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1399115002156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1399115002157 transcriptional regulator Hpr; Provisional; Region: PRK13777 1399115002158 MarR family; Region: MarR; pfam01047 1399115002159 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1399115002160 HIT family signature motif; other site 1399115002161 catalytic residue [active] 1399115002162 Predicted membrane protein [Function unknown]; Region: COG4640 1399115002163 Predicted membrane protein [Function unknown]; Region: COG2261 1399115002164 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1399115002165 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115002166 Walker A/P-loop; other site 1399115002167 ATP binding site [chemical binding]; other site 1399115002168 Q-loop/lid; other site 1399115002169 ABC transporter signature motif; other site 1399115002170 Walker B; other site 1399115002171 D-loop; other site 1399115002172 H-loop/switch region; other site 1399115002173 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1399115002174 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1399115002175 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1399115002176 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1399115002177 DNA binding residues [nucleotide binding] 1399115002178 putative dimer interface [polypeptide binding]; other site 1399115002179 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1399115002180 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1399115002181 substrate binding site [chemical binding]; other site 1399115002182 active site 1399115002183 ferrochelatase; Provisional; Region: PRK12435 1399115002184 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1399115002185 C-terminal domain interface [polypeptide binding]; other site 1399115002186 active site 1399115002187 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1399115002188 active site 1399115002189 N-terminal domain interface [polypeptide binding]; other site 1399115002190 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1399115002191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115002192 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1399115002193 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1399115002194 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1399115002195 putative active site [active] 1399115002196 catalytic site [active] 1399115002197 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1399115002198 putative active site [active] 1399115002199 catalytic site [active] 1399115002200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115002201 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1399115002202 active site 1399115002203 motif I; other site 1399115002204 motif II; other site 1399115002205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115002206 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1399115002207 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1399115002208 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1399115002209 Part of AAA domain; Region: AAA_19; pfam13245 1399115002210 Family description; Region: UvrD_C_2; pfam13538 1399115002211 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115002212 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1399115002213 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1399115002214 substrate binding [chemical binding]; other site 1399115002215 active site 1399115002216 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1399115002217 Cache domain; Region: Cache_1; pfam02743 1399115002218 HAMP domain; Region: HAMP; pfam00672 1399115002219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115002220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115002221 metal binding site [ion binding]; metal-binding site 1399115002222 active site 1399115002223 I-site; other site 1399115002224 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115002225 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115002226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115002227 Walker A/P-loop; other site 1399115002228 ATP binding site [chemical binding]; other site 1399115002229 Q-loop/lid; other site 1399115002230 ABC transporter signature motif; other site 1399115002231 Walker B; other site 1399115002232 D-loop; other site 1399115002233 H-loop/switch region; other site 1399115002234 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1399115002235 Predicted membrane protein [Function unknown]; Region: COG2364 1399115002236 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1399115002237 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1399115002238 amphipathic channel; other site 1399115002239 Asn-Pro-Ala signature motifs; other site 1399115002240 glycerol kinase; Provisional; Region: glpK; PRK00047 1399115002241 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1399115002242 N- and C-terminal domain interface [polypeptide binding]; other site 1399115002243 active site 1399115002244 MgATP binding site [chemical binding]; other site 1399115002245 catalytic site [active] 1399115002246 metal binding site [ion binding]; metal-binding site 1399115002247 glycerol binding site [chemical binding]; other site 1399115002248 homotetramer interface [polypeptide binding]; other site 1399115002249 homodimer interface [polypeptide binding]; other site 1399115002250 FBP binding site [chemical binding]; other site 1399115002251 protein IIAGlc interface [polypeptide binding]; other site 1399115002252 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1399115002253 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1399115002254 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1399115002255 catalytic residues [active] 1399115002256 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1399115002257 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1399115002258 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1399115002259 short chain dehydrogenase; Provisional; Region: PRK06701 1399115002260 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1399115002261 NAD binding site [chemical binding]; other site 1399115002262 metal binding site [ion binding]; metal-binding site 1399115002263 active site 1399115002264 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1399115002265 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1399115002266 acyl-activating enzyme (AAE) consensus motif; other site 1399115002267 putative AMP binding site [chemical binding]; other site 1399115002268 putative active site [active] 1399115002269 putative CoA binding site [chemical binding]; other site 1399115002270 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1399115002271 active site 1399115002272 dimer interfaces [polypeptide binding]; other site 1399115002273 catalytic residues [active] 1399115002274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115002275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115002276 active site 1399115002277 phosphorylation site [posttranslational modification] 1399115002278 intermolecular recognition site; other site 1399115002279 dimerization interface [polypeptide binding]; other site 1399115002280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115002281 DNA binding site [nucleotide binding] 1399115002282 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1399115002283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115002284 dimerization interface [polypeptide binding]; other site 1399115002285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115002286 dimer interface [polypeptide binding]; other site 1399115002287 phosphorylation site [posttranslational modification] 1399115002288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115002289 ATP binding site [chemical binding]; other site 1399115002290 Mg2+ binding site [ion binding]; other site 1399115002291 G-X-G motif; other site 1399115002292 ComK protein; Region: ComK; cl11560 1399115002293 Domain of unknown function (DUF370); Region: DUF370; cl00898 1399115002294 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1399115002295 heme-binding site [chemical binding]; other site 1399115002296 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1399115002297 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1399115002298 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1399115002299 Part of AAA domain; Region: AAA_19; pfam13245 1399115002300 Family description; Region: UvrD_C_2; pfam13538 1399115002301 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1399115002302 Response regulator receiver domain; Region: Response_reg; pfam00072 1399115002303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115002304 active site 1399115002305 phosphorylation site [posttranslational modification] 1399115002306 intermolecular recognition site; other site 1399115002307 dimerization interface [polypeptide binding]; other site 1399115002308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115002309 dimerization interface [polypeptide binding]; other site 1399115002310 GAF domain; Region: GAF_3; pfam13492 1399115002311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115002312 dimer interface [polypeptide binding]; other site 1399115002313 phosphorylation site [posttranslational modification] 1399115002314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115002315 ATP binding site [chemical binding]; other site 1399115002316 Mg2+ binding site [ion binding]; other site 1399115002317 G-X-G motif; other site 1399115002318 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 1399115002319 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1399115002320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115002321 S-adenosylmethionine binding site [chemical binding]; other site 1399115002322 phytoene desaturase; Region: crtI_fam; TIGR02734 1399115002323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115002324 phytoene desaturase; Region: crtI_fam; TIGR02734 1399115002325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115002326 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1399115002327 active site lid residues [active] 1399115002328 substrate binding pocket [chemical binding]; other site 1399115002329 catalytic residues [active] 1399115002330 substrate-Mg2+ binding site; other site 1399115002331 aspartate-rich region 1; other site 1399115002332 aspartate-rich region 2; other site 1399115002333 phytoene desaturase; Region: crtI_fam; TIGR02734 1399115002334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115002335 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1399115002336 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1399115002337 active site 1399115002338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1399115002339 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1399115002340 putative acyl-acceptor binding pocket; other site 1399115002341 Protein of unknown function (DUF422); Region: DUF422; cl00991 1399115002342 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1399115002343 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1399115002344 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1399115002345 putative deacylase active site [active] 1399115002346 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1399115002347 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1399115002348 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1399115002349 enoyl-CoA hydratase; Provisional; Region: PRK08140 1399115002350 substrate binding site [chemical binding]; other site 1399115002351 oxyanion hole (OAH) forming residues; other site 1399115002352 trimer interface [polypeptide binding]; other site 1399115002353 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1399115002354 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1399115002355 maltodextrin glucosidase; Provisional; Region: PRK10785 1399115002356 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1399115002357 homodimer interface [polypeptide binding]; other site 1399115002358 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1399115002359 active site 1399115002360 homodimer interface [polypeptide binding]; other site 1399115002361 catalytic site [active] 1399115002362 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1399115002363 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1399115002364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1399115002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115002366 dimer interface [polypeptide binding]; other site 1399115002367 conserved gate region; other site 1399115002368 ABC-ATPase subunit interface; other site 1399115002369 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1399115002370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115002371 dimer interface [polypeptide binding]; other site 1399115002372 conserved gate region; other site 1399115002373 putative PBP binding loops; other site 1399115002374 ABC-ATPase subunit interface; other site 1399115002375 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1399115002376 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1399115002377 active site 1399115002378 catalytic site [active] 1399115002379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1399115002380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1399115002381 DNA binding site [nucleotide binding] 1399115002382 domain linker motif; other site 1399115002383 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1399115002384 putative dimerization interface [polypeptide binding]; other site 1399115002385 putative ligand binding site [chemical binding]; other site 1399115002386 maltose phosphorylase; Provisional; Region: PRK13807 1399115002387 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1399115002388 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1399115002389 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1399115002390 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115002391 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115002392 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115002393 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115002394 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1399115002395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115002396 motif II; other site 1399115002397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115002398 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1399115002399 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1399115002400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1399115002401 active site 1399115002402 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1399115002403 catalytic residues [active] 1399115002404 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1399115002405 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1399115002406 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1399115002407 transmembrane helices; other site 1399115002408 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1399115002409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115002410 motif II; other site 1399115002411 GTPase YqeH; Provisional; Region: PRK13796 1399115002412 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1399115002413 GTP/Mg2+ binding site [chemical binding]; other site 1399115002414 G4 box; other site 1399115002415 G5 box; other site 1399115002416 G1 box; other site 1399115002417 Switch I region; other site 1399115002418 G2 box; other site 1399115002419 G3 box; other site 1399115002420 Switch II region; other site 1399115002421 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1399115002422 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1399115002423 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1399115002424 shikimate binding site; other site 1399115002425 NAD(P) binding site [chemical binding]; other site 1399115002426 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1399115002427 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1399115002428 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1399115002429 active site 1399115002430 (T/H)XGH motif; other site 1399115002431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115002432 Zn2+ binding site [ion binding]; other site 1399115002433 Mg2+ binding site [ion binding]; other site 1399115002434 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1399115002435 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1399115002436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115002437 S-adenosylmethionine binding site [chemical binding]; other site 1399115002438 SLBB domain; Region: SLBB; pfam10531 1399115002439 comEA protein; Region: comE; TIGR01259 1399115002440 Helix-hairpin-helix motif; Region: HHH; pfam00633 1399115002441 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1399115002442 Competence protein; Region: Competence; pfam03772 1399115002443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1399115002444 YqzM-like protein; Region: YqzM; pfam14141 1399115002445 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1399115002446 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1399115002447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1399115002448 Coenzyme A binding pocket [chemical binding]; other site 1399115002449 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1399115002450 GTP-binding protein LepA; Provisional; Region: PRK05433 1399115002451 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1399115002452 G1 box; other site 1399115002453 putative GEF interaction site [polypeptide binding]; other site 1399115002454 GTP/Mg2+ binding site [chemical binding]; other site 1399115002455 Switch I region; other site 1399115002456 G2 box; other site 1399115002457 G3 box; other site 1399115002458 Switch II region; other site 1399115002459 G4 box; other site 1399115002460 G5 box; other site 1399115002461 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1399115002462 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1399115002463 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1399115002464 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1399115002465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115002466 FeS/SAM binding site; other site 1399115002467 HemN C-terminal domain; Region: HemN_C; pfam06969 1399115002468 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1399115002469 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1399115002470 heat shock protein GrpE; Provisional; Region: PRK14140 1399115002471 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1399115002472 dimer interface [polypeptide binding]; other site 1399115002473 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1399115002474 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1399115002475 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1399115002476 nucleotide binding site [chemical binding]; other site 1399115002477 NEF interaction site [polypeptide binding]; other site 1399115002478 SBD interface [polypeptide binding]; other site 1399115002479 chaperone protein DnaJ; Provisional; Region: PRK14280 1399115002480 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1399115002481 HSP70 interaction site [polypeptide binding]; other site 1399115002482 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1399115002483 substrate binding site [polypeptide binding]; other site 1399115002484 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1399115002485 Zn binding sites [ion binding]; other site 1399115002486 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1399115002487 dimer interface [polypeptide binding]; other site 1399115002488 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1399115002489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115002490 S-adenosylmethionine binding site [chemical binding]; other site 1399115002491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1399115002492 RNA methyltransferase, RsmE family; Region: TIGR00046 1399115002493 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1399115002494 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1399115002495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115002496 FeS/SAM binding site; other site 1399115002497 TRAM domain; Region: TRAM; cl01282 1399115002498 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1399115002499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115002500 RNA binding surface [nucleotide binding]; other site 1399115002501 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1399115002502 probable active site [active] 1399115002503 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1399115002504 EamA-like transporter family; Region: EamA; pfam00892 1399115002505 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1399115002506 EamA-like transporter family; Region: EamA; pfam00892 1399115002507 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1399115002508 intersubunit interface [polypeptide binding]; other site 1399115002509 active site 1399115002510 catalytic residue [active] 1399115002511 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1399115002512 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 1399115002513 ligand binding site [chemical binding]; other site 1399115002514 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1399115002515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115002516 dimerization interface [polypeptide binding]; other site 1399115002517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115002518 dimer interface [polypeptide binding]; other site 1399115002519 putative CheW interface [polypeptide binding]; other site 1399115002520 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115002521 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115002522 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1399115002523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115002524 NAD(P) binding site [chemical binding]; other site 1399115002525 active site 1399115002526 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1399115002527 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1399115002528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115002529 motif II; other site 1399115002530 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1399115002531 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1399115002532 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1399115002533 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1399115002534 NAD(P) binding site [chemical binding]; other site 1399115002535 substrate binding site [chemical binding]; other site 1399115002536 dimer interface [polypeptide binding]; other site 1399115002537 adhesin; Provisional; Region: PRK09752 1399115002538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1399115002539 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1399115002540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1399115002541 active site 1399115002542 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1399115002543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115002544 S-adenosylmethionine binding site [chemical binding]; other site 1399115002545 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1399115002546 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1399115002547 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1399115002548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1399115002549 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1399115002550 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1399115002551 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1399115002552 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1399115002553 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1399115002554 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1399115002555 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1399115002556 Walker A/P-loop; other site 1399115002557 ATP binding site [chemical binding]; other site 1399115002558 Q-loop/lid; other site 1399115002559 ABC transporter signature motif; other site 1399115002560 Walker B; other site 1399115002561 D-loop; other site 1399115002562 H-loop/switch region; other site 1399115002563 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1399115002564 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1399115002565 active site 1399115002566 homodimer interface [polypeptide binding]; other site 1399115002567 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1399115002568 DHHW protein; Region: DHHW; pfam14286 1399115002569 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1399115002570 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1399115002571 carbohydrate binding site [chemical binding]; other site 1399115002572 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1399115002573 carbohydrate binding site [chemical binding]; other site 1399115002574 pullulanase, type I; Region: pulA_typeI; TIGR02104 1399115002575 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1399115002576 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1399115002577 Ca binding site [ion binding]; other site 1399115002578 active site 1399115002579 catalytic site [active] 1399115002580 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1399115002581 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1399115002582 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1399115002583 Yqey-like protein; Region: YqeY; pfam09424 1399115002584 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1399115002585 hypothetical protein; Provisional; Region: PRK13665 1399115002586 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1399115002587 PhoH-like protein; Region: PhoH; pfam02562 1399115002588 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1399115002589 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1399115002590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115002591 Zn2+ binding site [ion binding]; other site 1399115002592 Mg2+ binding site [ion binding]; other site 1399115002593 metal-binding heat shock protein; Provisional; Region: PRK00016 1399115002594 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1399115002595 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1399115002596 active site 1399115002597 catalytic motif [active] 1399115002598 Zn binding site [ion binding]; other site 1399115002599 GTPase Era; Reviewed; Region: era; PRK00089 1399115002600 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1399115002601 G1 box; other site 1399115002602 GTP/Mg2+ binding site [chemical binding]; other site 1399115002603 Switch I region; other site 1399115002604 G2 box; other site 1399115002605 Switch II region; other site 1399115002606 G3 box; other site 1399115002607 G4 box; other site 1399115002608 G5 box; other site 1399115002609 KH domain; Region: KH_2; pfam07650 1399115002610 DNA repair protein RecO; Region: reco; TIGR00613 1399115002611 Recombination protein O N terminal; Region: RecO_N; pfam11967 1399115002612 Recombination protein O C terminal; Region: RecO_C; pfam02565 1399115002613 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1399115002614 dimer interface [polypeptide binding]; other site 1399115002615 motif 1; other site 1399115002616 active site 1399115002617 motif 2; other site 1399115002618 motif 3; other site 1399115002619 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1399115002620 DALR anticodon binding domain; Region: DALR_1; pfam05746 1399115002621 HTH domain; Region: HTH_11; pfam08279 1399115002622 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1399115002623 FOG: CBS domain [General function prediction only]; Region: COG0517 1399115002624 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1399115002625 DNA primase; Validated; Region: dnaG; PRK05667 1399115002626 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1399115002627 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1399115002628 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1399115002629 active site 1399115002630 metal binding site [ion binding]; metal-binding site 1399115002631 interdomain interaction site; other site 1399115002632 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1399115002633 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1399115002634 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1399115002635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115002636 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1399115002637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115002638 DNA binding residues [nucleotide binding] 1399115002639 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1399115002640 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1399115002641 Family of unknown function (DUF633); Region: DUF633; pfam04816 1399115002642 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1399115002643 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1399115002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1399115002645 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1399115002646 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1399115002647 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1399115002648 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1399115002649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115002650 HAMP domain; Region: HAMP; pfam00672 1399115002651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115002652 dimer interface [polypeptide binding]; other site 1399115002653 phosphorylation site [posttranslational modification] 1399115002654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115002655 ATP binding site [chemical binding]; other site 1399115002656 Mg2+ binding site [ion binding]; other site 1399115002657 G-X-G motif; other site 1399115002658 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1399115002659 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1399115002660 ligand binding site [chemical binding]; other site 1399115002661 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1399115002662 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1399115002663 ATP binding site [chemical binding]; other site 1399115002664 Mg++ binding site [ion binding]; other site 1399115002665 motif III; other site 1399115002666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115002667 nucleotide binding region [chemical binding]; other site 1399115002668 ATP-binding site [chemical binding]; other site 1399115002669 endonuclease IV; Provisional; Region: PRK01060 1399115002670 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1399115002671 AP (apurinic/apyrimidinic) site pocket; other site 1399115002672 DNA interaction; other site 1399115002673 Metal-binding active site; metal-binding site 1399115002674 polyphosphate kinase; Provisional; Region: PRK05443 1399115002675 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1399115002676 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1399115002677 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1399115002678 putative domain interface [polypeptide binding]; other site 1399115002679 putative active site [active] 1399115002680 catalytic site [active] 1399115002681 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1399115002682 putative domain interface [polypeptide binding]; other site 1399115002683 putative active site [active] 1399115002684 catalytic site [active] 1399115002685 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1399115002686 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1399115002687 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1399115002688 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1399115002689 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1399115002690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115002691 ABC-ATPase subunit interface; other site 1399115002692 dimer interface [polypeptide binding]; other site 1399115002693 putative PBP binding regions; other site 1399115002694 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1399115002695 metal binding site 2 [ion binding]; metal-binding site 1399115002696 putative DNA binding helix; other site 1399115002697 metal binding site 1 [ion binding]; metal-binding site 1399115002698 dimer interface [polypeptide binding]; other site 1399115002699 structural Zn2+ binding site [ion binding]; other site 1399115002700 putative carbohydrate kinase; Provisional; Region: PRK10565 1399115002701 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1399115002702 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1399115002703 putative substrate binding site [chemical binding]; other site 1399115002704 putative ATP binding site [chemical binding]; other site 1399115002705 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115002706 metal binding site [ion binding]; metal-binding site 1399115002707 active site 1399115002708 I-site; other site 1399115002709 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115002710 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115002711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115002712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115002713 metal binding site [ion binding]; metal-binding site 1399115002714 active site 1399115002715 I-site; other site 1399115002716 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1399115002717 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1399115002718 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1399115002719 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1399115002720 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1399115002721 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1399115002722 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1399115002723 PhoU domain; Region: PhoU; pfam01895 1399115002724 PhoU domain; Region: PhoU; pfam01895 1399115002725 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1399115002726 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1399115002727 active site 1399115002728 Na/Ca binding site [ion binding]; other site 1399115002729 catalytic site [active] 1399115002730 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1399115002731 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1399115002732 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1399115002733 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1399115002734 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1399115002735 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1399115002736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1399115002737 PBP superfamily domain; Region: PBP_like_2; cl17296 1399115002738 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1399115002739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115002740 dimer interface [polypeptide binding]; other site 1399115002741 conserved gate region; other site 1399115002742 putative PBP binding loops; other site 1399115002743 ABC-ATPase subunit interface; other site 1399115002744 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1399115002745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115002746 dimer interface [polypeptide binding]; other site 1399115002747 conserved gate region; other site 1399115002748 putative PBP binding loops; other site 1399115002749 ABC-ATPase subunit interface; other site 1399115002750 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1399115002751 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1399115002752 Walker A/P-loop; other site 1399115002753 ATP binding site [chemical binding]; other site 1399115002754 Q-loop/lid; other site 1399115002755 ABC transporter signature motif; other site 1399115002756 Walker B; other site 1399115002757 D-loop; other site 1399115002758 H-loop/switch region; other site 1399115002759 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1399115002760 PhoU domain; Region: PhoU; pfam01895 1399115002761 PhoU domain; Region: PhoU; pfam01895 1399115002762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1399115002763 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1399115002764 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1399115002765 active site 1399115002766 substrate binding site [chemical binding]; other site 1399115002767 catalytic site [active] 1399115002768 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1399115002769 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1399115002770 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1399115002771 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1399115002772 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1399115002773 Integral membrane protein DUF92; Region: DUF92; pfam01940 1399115002774 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1399115002775 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1399115002776 NAD binding site [chemical binding]; other site 1399115002777 dimer interface [polypeptide binding]; other site 1399115002778 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1399115002779 substrate binding site [chemical binding]; other site 1399115002780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1399115002781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115002782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115002783 Coenzyme A binding pocket [chemical binding]; other site 1399115002784 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1399115002785 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1399115002786 putative oligomer interface [polypeptide binding]; other site 1399115002787 putative active site [active] 1399115002788 metal binding site [ion binding]; metal-binding site 1399115002789 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1399115002790 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1399115002791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1399115002792 nucleotide binding site [chemical binding]; other site 1399115002793 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1399115002794 Sulfatase; Region: Sulfatase; pfam00884 1399115002795 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1399115002796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115002797 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1399115002798 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1399115002799 ArsC family; Region: ArsC; pfam03960 1399115002800 putative catalytic residues [active] 1399115002801 thiol/disulfide switch; other site 1399115002802 Type II/IV secretion system protein; Region: T2SE; pfam00437 1399115002803 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1399115002804 Walker A motif; other site 1399115002805 ATP binding site [chemical binding]; other site 1399115002806 Walker B motif; other site 1399115002807 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1399115002808 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1399115002809 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1399115002810 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1399115002811 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1399115002812 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1399115002813 aminopeptidase N; Provisional; Region: pepN; PRK14015 1399115002814 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1399115002815 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1399115002816 ADP binding site [chemical binding]; other site 1399115002817 magnesium binding site [ion binding]; other site 1399115002818 putative shikimate binding site; other site 1399115002819 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1399115002820 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1399115002821 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1399115002822 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1399115002823 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1399115002824 tetramer interface [polypeptide binding]; other site 1399115002825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115002826 catalytic residue [active] 1399115002827 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1399115002828 tetramer interface [polypeptide binding]; other site 1399115002829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115002830 catalytic residue [active] 1399115002831 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1399115002832 active site residue [active] 1399115002833 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1399115002834 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1399115002835 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1399115002836 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1399115002837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115002838 active site 1399115002839 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1399115002840 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1399115002841 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1399115002842 active site 1399115002843 trimer interface [polypeptide binding]; other site 1399115002844 dimer interface [polypeptide binding]; other site 1399115002845 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1399115002846 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1399115002847 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1399115002848 active site 1399115002849 elongation factor P; Validated; Region: PRK00529 1399115002850 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1399115002851 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1399115002852 RNA binding site [nucleotide binding]; other site 1399115002853 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1399115002854 RNA binding site [nucleotide binding]; other site 1399115002855 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1399115002856 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1399115002857 carboxyltransferase (CT) interaction site; other site 1399115002858 biotinylation site [posttranslational modification]; other site 1399115002859 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1399115002860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1399115002861 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115002862 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1399115002863 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1399115002864 putative RNA binding site [nucleotide binding]; other site 1399115002865 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1399115002866 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1399115002867 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1399115002868 homodimer interface [polypeptide binding]; other site 1399115002869 NADP binding site [chemical binding]; other site 1399115002870 substrate binding site [chemical binding]; other site 1399115002871 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1399115002872 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1399115002873 generic binding surface II; other site 1399115002874 generic binding surface I; other site 1399115002875 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1399115002876 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1399115002877 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1399115002878 substrate binding pocket [chemical binding]; other site 1399115002879 chain length determination region; other site 1399115002880 substrate-Mg2+ binding site; other site 1399115002881 catalytic residues [active] 1399115002882 aspartate-rich region 1; other site 1399115002883 active site lid residues [active] 1399115002884 aspartate-rich region 2; other site 1399115002885 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1399115002886 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1399115002887 TPP-binding site; other site 1399115002888 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1399115002889 PYR/PP interface [polypeptide binding]; other site 1399115002890 dimer interface [polypeptide binding]; other site 1399115002891 TPP binding site [chemical binding]; other site 1399115002892 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1399115002893 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1399115002894 arginine repressor; Provisional; Region: PRK04280 1399115002895 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1399115002896 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1399115002897 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1399115002898 Walker A/P-loop; other site 1399115002899 ATP binding site [chemical binding]; other site 1399115002900 Q-loop/lid; other site 1399115002901 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1399115002902 ABC transporter signature motif; other site 1399115002903 Walker B; other site 1399115002904 D-loop; other site 1399115002905 H-loop/switch region; other site 1399115002906 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1399115002907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115002908 active site 1399115002909 phosphorylation site [posttranslational modification] 1399115002910 intermolecular recognition site; other site 1399115002911 dimerization interface [polypeptide binding]; other site 1399115002912 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1399115002913 RibD C-terminal domain; Region: RibD_C; cl17279 1399115002914 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1399115002915 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1399115002916 PAS domain S-box; Region: sensory_box; TIGR00229 1399115002917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115002918 putative active site [active] 1399115002919 heme pocket [chemical binding]; other site 1399115002920 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1399115002921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115002922 Walker A motif; other site 1399115002923 ATP binding site [chemical binding]; other site 1399115002924 Walker B motif; other site 1399115002925 arginine finger; other site 1399115002926 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1399115002927 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1399115002928 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1399115002929 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1399115002930 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1399115002931 NAD binding site [chemical binding]; other site 1399115002932 Phe binding site; other site 1399115002933 butyrate kinase; Provisional; Region: PRK03011 1399115002934 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1399115002935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115002936 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115002937 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1399115002938 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1399115002939 tetramer interface [polypeptide binding]; other site 1399115002940 TPP-binding site [chemical binding]; other site 1399115002941 heterodimer interface [polypeptide binding]; other site 1399115002942 phosphorylation loop region [posttranslational modification] 1399115002943 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1399115002944 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1399115002945 alpha subunit interface [polypeptide binding]; other site 1399115002946 TPP binding site [chemical binding]; other site 1399115002947 heterodimer interface [polypeptide binding]; other site 1399115002948 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1399115002949 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1399115002950 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1399115002951 E3 interaction surface; other site 1399115002952 lipoyl attachment site [posttranslational modification]; other site 1399115002953 e3 binding domain; Region: E3_binding; pfam02817 1399115002954 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1399115002955 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115002956 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115002957 anthranilate synthase component I; Provisional; Region: PRK13570 1399115002958 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1399115002959 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1399115002960 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1399115002961 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1399115002962 glutamine binding [chemical binding]; other site 1399115002963 catalytic triad [active] 1399115002964 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1399115002965 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1399115002966 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1399115002967 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1399115002968 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1399115002969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115002970 catalytic residue [active] 1399115002971 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1399115002972 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1399115002973 substrate binding site [chemical binding]; other site 1399115002974 active site 1399115002975 catalytic residues [active] 1399115002976 heterodimer interface [polypeptide binding]; other site 1399115002977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115002978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115002979 Coenzyme A binding pocket [chemical binding]; other site 1399115002980 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1399115002981 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1399115002982 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1399115002983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1399115002984 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115002985 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115002986 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115002987 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1399115002988 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1399115002989 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1399115002990 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1399115002991 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1399115002992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115002993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115002994 ABC transporter; Region: ABC_tran_2; pfam12848 1399115002995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115002996 Predicted secreted protein [Function unknown]; Region: COG4086 1399115002997 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1399115002998 Putative transcription activator [Transcription]; Region: TenA; COG0819 1399115002999 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1399115003000 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1399115003001 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1399115003002 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1399115003003 SpoOM protein; Region: Spo0M; pfam07070 1399115003004 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1399115003005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115003006 S-adenosylmethionine binding site [chemical binding]; other site 1399115003007 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1399115003008 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1399115003009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1399115003010 substrate binding pocket [chemical binding]; other site 1399115003011 membrane-bound complex binding site; other site 1399115003012 hinge residues; other site 1399115003013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115003014 dimer interface [polypeptide binding]; other site 1399115003015 conserved gate region; other site 1399115003016 putative PBP binding loops; other site 1399115003017 ABC-ATPase subunit interface; other site 1399115003018 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1399115003019 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1399115003020 Walker A/P-loop; other site 1399115003021 ATP binding site [chemical binding]; other site 1399115003022 Q-loop/lid; other site 1399115003023 ABC transporter signature motif; other site 1399115003024 Walker B; other site 1399115003025 D-loop; other site 1399115003026 H-loop/switch region; other site 1399115003027 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115003028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115003029 Coenzyme A binding pocket [chemical binding]; other site 1399115003030 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1399115003031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115003032 Zn2+ binding site [ion binding]; other site 1399115003033 Mg2+ binding site [ion binding]; other site 1399115003034 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1399115003035 short chain dehydrogenase; Provisional; Region: PRK07677 1399115003036 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1399115003037 NAD(P) binding site [chemical binding]; other site 1399115003038 substrate binding site [chemical binding]; other site 1399115003039 homotetramer interface [polypeptide binding]; other site 1399115003040 active site 1399115003041 homodimer interface [polypeptide binding]; other site 1399115003042 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1399115003043 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1399115003044 DHHA2 domain; Region: DHHA2; pfam02833 1399115003045 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1399115003046 Predicted membrane protein [Function unknown]; Region: COG4129 1399115003047 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1399115003048 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1399115003049 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1399115003050 peptidase T-like protein; Region: PepT-like; TIGR01883 1399115003051 metal binding site [ion binding]; metal-binding site 1399115003052 putative dimer interface [polypeptide binding]; other site 1399115003053 ribonuclease Z; Region: RNase_Z; TIGR02651 1399115003054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115003055 ABC transporter signature motif; other site 1399115003056 Walker B; other site 1399115003057 D-loop; other site 1399115003058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1399115003059 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1399115003060 Walker A/P-loop; other site 1399115003061 ATP binding site [chemical binding]; other site 1399115003062 ABC transporter signature motif; other site 1399115003063 Walker B; other site 1399115003064 D-loop; other site 1399115003065 H-loop/switch region; other site 1399115003066 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1399115003067 short chain dehydrogenase; Provisional; Region: PRK08267 1399115003068 classical (c) SDRs; Region: SDR_c; cd05233 1399115003069 NAD(P) binding site [chemical binding]; other site 1399115003070 active site 1399115003071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115003072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003074 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1399115003075 EamA-like transporter family; Region: EamA; pfam00892 1399115003076 DNA topoisomerase III; Provisional; Region: PRK07726 1399115003077 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1399115003078 active site 1399115003079 putative interdomain interaction site [polypeptide binding]; other site 1399115003080 putative metal-binding site [ion binding]; other site 1399115003081 putative nucleotide binding site [chemical binding]; other site 1399115003082 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1399115003083 domain I; other site 1399115003084 DNA binding groove [nucleotide binding] 1399115003085 phosphate binding site [ion binding]; other site 1399115003086 domain II; other site 1399115003087 domain III; other site 1399115003088 nucleotide binding site [chemical binding]; other site 1399115003089 catalytic site [active] 1399115003090 domain IV; other site 1399115003091 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1399115003092 HAMP domain; Region: HAMP; pfam00672 1399115003093 GAF domain; Region: GAF_3; pfam13492 1399115003094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115003095 dimer interface [polypeptide binding]; other site 1399115003096 phosphorylation site [posttranslational modification] 1399115003097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115003098 ATP binding site [chemical binding]; other site 1399115003099 Mg2+ binding site [ion binding]; other site 1399115003100 G-X-G motif; other site 1399115003101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115003102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003103 H+ Antiporter protein; Region: 2A0121; TIGR00900 1399115003104 putative substrate translocation pore; other site 1399115003105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115003106 dimer interface [polypeptide binding]; other site 1399115003107 conserved gate region; other site 1399115003108 putative PBP binding loops; other site 1399115003109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1399115003110 ABC-ATPase subunit interface; other site 1399115003111 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1399115003112 Protein of unknown function DUF58; Region: DUF58; pfam01882 1399115003113 MoxR-like ATPases [General function prediction only]; Region: COG0714 1399115003114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115003115 Walker A motif; other site 1399115003116 ATP binding site [chemical binding]; other site 1399115003117 Walker B motif; other site 1399115003118 arginine finger; other site 1399115003119 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1399115003120 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115003121 NAD binding site [chemical binding]; other site 1399115003122 substrate binding site [chemical binding]; other site 1399115003123 putative active site [active] 1399115003124 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1399115003125 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1399115003126 active site 1399115003127 Na/Ca binding site [ion binding]; other site 1399115003128 catalytic site [active] 1399115003129 Endonuclease I; Region: Endonuclease_1; pfam04231 1399115003130 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1399115003131 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1399115003132 putative active site [active] 1399115003133 Response regulator receiver domain; Region: Response_reg; pfam00072 1399115003134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115003135 active site 1399115003136 phosphorylation site [posttranslational modification] 1399115003137 intermolecular recognition site; other site 1399115003138 dimerization interface [polypeptide binding]; other site 1399115003139 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1399115003140 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1399115003141 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1399115003142 Cl binding site [ion binding]; other site 1399115003143 oligomer interface [polypeptide binding]; other site 1399115003144 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1399115003145 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1399115003146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115003147 active site 1399115003148 phosphorylation site [posttranslational modification] 1399115003149 intermolecular recognition site; other site 1399115003150 dimerization interface [polypeptide binding]; other site 1399115003151 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1399115003152 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1399115003153 tetrameric interface [polypeptide binding]; other site 1399115003154 activator binding site; other site 1399115003155 NADP binding site [chemical binding]; other site 1399115003156 substrate binding site [chemical binding]; other site 1399115003157 catalytic residues [active] 1399115003158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115003159 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1399115003160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115003161 NAD(P) binding site [chemical binding]; other site 1399115003162 active site 1399115003163 hypothetical protein; Provisional; Region: PRK11622 1399115003164 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1399115003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1399115003166 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1399115003167 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1399115003168 Walker A/P-loop; other site 1399115003169 ATP binding site [chemical binding]; other site 1399115003170 Q-loop/lid; other site 1399115003171 ABC transporter signature motif; other site 1399115003172 Walker B; other site 1399115003173 D-loop; other site 1399115003174 H-loop/switch region; other site 1399115003175 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1399115003176 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1399115003177 nudix motif; other site 1399115003178 Predicted transcriptional regulators [Transcription]; Region: COG1695 1399115003179 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1399115003180 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1399115003181 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1399115003182 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1399115003183 potential catalytic triad [active] 1399115003184 conserved cys residue [active] 1399115003185 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115003186 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115003187 active site 1399115003188 catalytic tetrad [active] 1399115003189 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1399115003190 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1399115003191 dimer interface [polypeptide binding]; other site 1399115003192 ADP-ribose binding site [chemical binding]; other site 1399115003193 active site 1399115003194 nudix motif; other site 1399115003195 metal binding site [ion binding]; metal-binding site 1399115003196 ferric uptake regulator; Provisional; Region: fur; PRK09462 1399115003197 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1399115003198 metal binding site 2 [ion binding]; metal-binding site 1399115003199 putative DNA binding helix; other site 1399115003200 metal binding site 1 [ion binding]; metal-binding site 1399115003201 dimer interface [polypeptide binding]; other site 1399115003202 structural Zn2+ binding site [ion binding]; other site 1399115003203 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1399115003204 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1399115003205 active site 1399115003206 Int/Topo IB signature motif; other site 1399115003207 phosphopentomutase; Provisional; Region: PRK05362 1399115003208 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1399115003209 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1399115003210 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1399115003211 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1399115003212 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1399115003213 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1399115003214 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1399115003215 putative dimer interface [polypeptide binding]; other site 1399115003216 catalytic triad [active] 1399115003217 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1399115003218 active site 1399115003219 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1399115003220 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1399115003221 proposed catalytic triad [active] 1399115003222 conserved cys residue [active] 1399115003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1399115003224 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1399115003225 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1399115003226 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1399115003227 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1399115003228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115003229 RNA binding surface [nucleotide binding]; other site 1399115003230 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1399115003231 active site 1399115003232 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1399115003233 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1399115003234 catalytic residues [active] 1399115003235 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1399115003236 ResB-like family; Region: ResB; pfam05140 1399115003237 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1399115003238 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1399115003239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115003240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115003241 active site 1399115003242 phosphorylation site [posttranslational modification] 1399115003243 intermolecular recognition site; other site 1399115003244 dimerization interface [polypeptide binding]; other site 1399115003245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115003246 DNA binding site [nucleotide binding] 1399115003247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1399115003248 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115003249 dimerization interface [polypeptide binding]; other site 1399115003250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115003251 dimer interface [polypeptide binding]; other site 1399115003252 phosphorylation site [posttranslational modification] 1399115003253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115003254 ATP binding site [chemical binding]; other site 1399115003255 Mg2+ binding site [ion binding]; other site 1399115003256 G-X-G motif; other site 1399115003257 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1399115003258 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1399115003259 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1399115003260 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1399115003261 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1399115003262 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1399115003263 classical (c) SDRs; Region: SDR_c; cd05233 1399115003264 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1399115003265 NAD(P) binding site [chemical binding]; other site 1399115003266 active site 1399115003267 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1399115003268 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1399115003269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115003270 non-specific DNA binding site [nucleotide binding]; other site 1399115003271 salt bridge; other site 1399115003272 sequence-specific DNA binding site [nucleotide binding]; other site 1399115003273 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1399115003274 competence damage-inducible protein A; Provisional; Region: PRK00549 1399115003275 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1399115003276 putative MPT binding site; other site 1399115003277 Competence-damaged protein; Region: CinA; pfam02464 1399115003278 recombinase A; Provisional; Region: recA; PRK09354 1399115003279 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1399115003280 hexamer interface [polypeptide binding]; other site 1399115003281 Walker A motif; other site 1399115003282 ATP binding site [chemical binding]; other site 1399115003283 Walker B motif; other site 1399115003284 phosphodiesterase; Provisional; Region: PRK12704 1399115003285 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1399115003286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115003287 Zn2+ binding site [ion binding]; other site 1399115003288 Mg2+ binding site [ion binding]; other site 1399115003289 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1399115003290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1399115003291 putative active site [active] 1399115003292 metal binding site [ion binding]; metal-binding site 1399115003293 homodimer binding site [polypeptide binding]; other site 1399115003294 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1399115003295 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1399115003296 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1399115003297 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1399115003298 PYR/PP interface [polypeptide binding]; other site 1399115003299 TPP binding site [chemical binding]; other site 1399115003300 dimer interface [polypeptide binding]; other site 1399115003301 substrate binding site [chemical binding]; other site 1399115003302 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1399115003303 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1399115003304 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1399115003305 TPP-binding site [chemical binding]; other site 1399115003306 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1399115003307 Threonine dehydrogenase; Region: TDH; cd05281 1399115003308 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1399115003309 structural Zn binding site [ion binding]; other site 1399115003310 catalytic Zn binding site [ion binding]; other site 1399115003311 tetramer interface [polypeptide binding]; other site 1399115003312 NADP binding site [chemical binding]; other site 1399115003313 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1399115003314 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1399115003315 substrate-cofactor binding pocket; other site 1399115003316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115003317 catalytic residue [active] 1399115003318 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1399115003319 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1399115003320 PGAP1-like protein; Region: PGAP1; pfam07819 1399115003321 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1399115003322 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1399115003323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1399115003324 endonuclease III; Region: ENDO3c; smart00478 1399115003325 minor groove reading motif; other site 1399115003326 helix-hairpin-helix signature motif; other site 1399115003327 substrate binding pocket [chemical binding]; other site 1399115003328 active site 1399115003329 Predicted membrane protein [Function unknown]; Region: COG4550 1399115003330 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1399115003331 MutS domain I; Region: MutS_I; pfam01624 1399115003332 MutS domain II; Region: MutS_II; pfam05188 1399115003333 MutS domain III; Region: MutS_III; pfam05192 1399115003334 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1399115003335 Walker A/P-loop; other site 1399115003336 ATP binding site [chemical binding]; other site 1399115003337 Q-loop/lid; other site 1399115003338 ABC transporter signature motif; other site 1399115003339 Walker B; other site 1399115003340 D-loop; other site 1399115003341 H-loop/switch region; other site 1399115003342 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1399115003343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115003344 ATP binding site [chemical binding]; other site 1399115003345 Mg2+ binding site [ion binding]; other site 1399115003346 G-X-G motif; other site 1399115003347 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1399115003348 ATP binding site [chemical binding]; other site 1399115003349 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1399115003350 LrgA family; Region: LrgA; cl00608 1399115003351 LrgB-like family; Region: LrgB; pfam04172 1399115003352 AAA domain; Region: AAA_17; cl17253 1399115003353 AAA domain; Region: AAA_18; pfam13238 1399115003354 HAMP domain; Region: HAMP; pfam00672 1399115003355 GAF domain; Region: GAF_3; pfam13492 1399115003356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115003357 dimer interface [polypeptide binding]; other site 1399115003358 phosphorylation site [posttranslational modification] 1399115003359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115003360 ATP binding site [chemical binding]; other site 1399115003361 Mg2+ binding site [ion binding]; other site 1399115003362 G-X-G motif; other site 1399115003363 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 1399115003364 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1399115003365 effector binding site; other site 1399115003366 active site 1399115003367 Zn binding site [ion binding]; other site 1399115003368 glycine loop; other site 1399115003369 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1399115003370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115003371 FeS/SAM binding site; other site 1399115003372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115003374 putative substrate translocation pore; other site 1399115003375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115003377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115003378 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1399115003379 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1399115003380 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1399115003381 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1399115003382 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1399115003383 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1399115003384 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1399115003385 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1399115003386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1399115003387 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1399115003388 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1399115003389 putative substrate binding site [chemical binding]; other site 1399115003390 putative ATP binding site [chemical binding]; other site 1399115003391 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1399115003392 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1399115003393 active site 1399115003394 phosphorylation site [posttranslational modification] 1399115003395 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1399115003396 active site 1399115003397 P-loop; other site 1399115003398 phosphorylation site [posttranslational modification] 1399115003399 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1399115003400 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1399115003401 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115003402 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1399115003403 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1399115003404 cofactor binding site; other site 1399115003405 metal binding site [ion binding]; metal-binding site 1399115003406 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1399115003407 putative nucleotide binding site [chemical binding]; other site 1399115003408 putative metal binding site [ion binding]; other site 1399115003409 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1399115003410 DNA binding site [nucleotide binding] 1399115003411 active site 1399115003412 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1399115003413 Cation efflux family; Region: Cation_efflux; pfam01545 1399115003414 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1399115003415 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1399115003416 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1399115003417 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1399115003418 H+ Antiporter protein; Region: 2A0121; TIGR00900 1399115003419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115003420 non-specific DNA binding site [nucleotide binding]; other site 1399115003421 salt bridge; other site 1399115003422 sequence-specific DNA binding site [nucleotide binding]; other site 1399115003423 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003424 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003425 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003426 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003427 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1399115003428 NlpC/P60 family; Region: NLPC_P60; pfam00877 1399115003429 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1399115003430 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115003431 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1399115003432 Walker A/P-loop; other site 1399115003433 ATP binding site [chemical binding]; other site 1399115003434 Q-loop/lid; other site 1399115003435 ABC transporter signature motif; other site 1399115003436 Walker B; other site 1399115003437 D-loop; other site 1399115003438 H-loop/switch region; other site 1399115003439 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1399115003440 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1399115003441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115003442 serine endoprotease; Provisional; Region: PRK10898 1399115003443 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1399115003444 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1399115003445 protein binding site [polypeptide binding]; other site 1399115003446 Predicted membrane protein [Function unknown]; Region: COG4270 1399115003447 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1399115003448 active site 1399115003449 catalytic triad [active] 1399115003450 oxyanion hole [active] 1399115003451 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115003452 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1399115003453 Walker A/P-loop; other site 1399115003454 ATP binding site [chemical binding]; other site 1399115003455 Q-loop/lid; other site 1399115003456 ABC transporter signature motif; other site 1399115003457 Walker B; other site 1399115003458 D-loop; other site 1399115003459 H-loop/switch region; other site 1399115003460 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1399115003461 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1399115003462 AAA domain; Region: AAA_17; cl17253 1399115003463 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1399115003464 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1399115003465 bacterial Hfq-like; Region: Hfq; cd01716 1399115003466 hexamer interface [polypeptide binding]; other site 1399115003467 Sm1 motif; other site 1399115003468 RNA binding site [nucleotide binding]; other site 1399115003469 Sm2 motif; other site 1399115003470 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1399115003471 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1399115003472 active site 1399115003473 Int/Topo IB signature motif; other site 1399115003474 DNA binding site [nucleotide binding] 1399115003475 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1399115003476 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1399115003477 HflX GTPase family; Region: HflX; cd01878 1399115003478 G1 box; other site 1399115003479 GTP/Mg2+ binding site [chemical binding]; other site 1399115003480 Switch I region; other site 1399115003481 G2 box; other site 1399115003482 G3 box; other site 1399115003483 Switch II region; other site 1399115003484 G4 box; other site 1399115003485 G5 box; other site 1399115003486 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1399115003487 Aluminium resistance protein; Region: Alum_res; pfam06838 1399115003488 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1399115003489 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1399115003490 DNA binding residues [nucleotide binding] 1399115003491 glutamine synthetase, type I; Region: GlnA; TIGR00653 1399115003492 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1399115003493 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1399115003494 Predicted membrane protein [Function unknown]; Region: COG4392 1399115003495 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1399115003496 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1399115003497 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1399115003498 DAK2 domain; Region: Dak2; cl03685 1399115003499 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1399115003500 glycerol kinase; Provisional; Region: glpK; PRK00047 1399115003501 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1399115003502 N- and C-terminal domain interface [polypeptide binding]; other site 1399115003503 active site 1399115003504 MgATP binding site [chemical binding]; other site 1399115003505 catalytic site [active] 1399115003506 metal binding site [ion binding]; metal-binding site 1399115003507 glycerol binding site [chemical binding]; other site 1399115003508 homotetramer interface [polypeptide binding]; other site 1399115003509 homodimer interface [polypeptide binding]; other site 1399115003510 FBP binding site [chemical binding]; other site 1399115003511 protein IIAGlc interface [polypeptide binding]; other site 1399115003512 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1399115003513 amphipathic channel; other site 1399115003514 Asn-Pro-Ala signature motifs; other site 1399115003515 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1399115003516 LexA repressor; Validated; Region: PRK00215 1399115003517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115003518 putative DNA binding site [nucleotide binding]; other site 1399115003519 putative Zn2+ binding site [ion binding]; other site 1399115003520 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1399115003521 Catalytic site [active] 1399115003522 cell division suppressor protein YneA; Provisional; Region: PRK14125 1399115003523 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1399115003524 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1399115003525 catalytic residues [active] 1399115003526 catalytic nucleophile [active] 1399115003527 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1399115003528 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1399115003529 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1399115003530 TPP-binding site [chemical binding]; other site 1399115003531 dimer interface [polypeptide binding]; other site 1399115003532 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1399115003533 PYR/PP interface [polypeptide binding]; other site 1399115003534 dimer interface [polypeptide binding]; other site 1399115003535 TPP binding site [chemical binding]; other site 1399115003536 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1399115003537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1399115003538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115003539 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1399115003540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115003541 Walker A/P-loop; other site 1399115003542 ATP binding site [chemical binding]; other site 1399115003543 Q-loop/lid; other site 1399115003544 ABC transporter signature motif; other site 1399115003545 Walker B; other site 1399115003546 D-loop; other site 1399115003547 H-loop/switch region; other site 1399115003548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1399115003549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115003550 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1399115003551 Walker A/P-loop; other site 1399115003552 ATP binding site [chemical binding]; other site 1399115003553 Q-loop/lid; other site 1399115003554 ABC transporter signature motif; other site 1399115003555 Walker B; other site 1399115003556 D-loop; other site 1399115003557 H-loop/switch region; other site 1399115003558 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003559 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003560 3D domain; Region: 3D; cl01439 1399115003561 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1399115003562 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1399115003563 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1399115003564 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1399115003565 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1399115003566 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1399115003567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115003568 dimer interface [polypeptide binding]; other site 1399115003569 putative metal binding site [ion binding]; other site 1399115003570 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1399115003571 putative dimer interface [polypeptide binding]; other site 1399115003572 catalytic triad [active] 1399115003573 Rrf2 family protein; Region: rrf2_super; TIGR00738 1399115003574 Transcriptional regulator; Region: Rrf2; pfam02082 1399115003575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115003577 putative substrate translocation pore; other site 1399115003578 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1399115003579 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1399115003580 G1 box; other site 1399115003581 putative GEF interaction site [polypeptide binding]; other site 1399115003582 GTP/Mg2+ binding site [chemical binding]; other site 1399115003583 Switch I region; other site 1399115003584 G2 box; other site 1399115003585 G3 box; other site 1399115003586 Switch II region; other site 1399115003587 G4 box; other site 1399115003588 G5 box; other site 1399115003589 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1399115003590 Heat induced stress protein YflT; Region: YflT; pfam11181 1399115003591 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1399115003592 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1399115003593 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1399115003594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115003595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115003596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1399115003597 dimerization interface [polypeptide binding]; other site 1399115003598 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1399115003599 Haemolysin E (HlyE); Region: HlyE; cl11627 1399115003600 aconitate hydratase; Validated; Region: PRK09277 1399115003601 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1399115003602 substrate binding site [chemical binding]; other site 1399115003603 ligand binding site [chemical binding]; other site 1399115003604 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1399115003605 substrate binding site [chemical binding]; other site 1399115003606 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 1399115003607 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1399115003608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115003609 Walker A motif; other site 1399115003610 ATP binding site [chemical binding]; other site 1399115003611 Walker B motif; other site 1399115003612 arginine finger; other site 1399115003613 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1399115003614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115003615 Walker A motif; other site 1399115003616 ATP binding site [chemical binding]; other site 1399115003617 Walker B motif; other site 1399115003618 arginine finger; other site 1399115003619 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1399115003620 active site 1399115003621 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1399115003622 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1399115003623 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1399115003624 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1399115003625 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1399115003626 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1399115003627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1399115003628 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1399115003629 Protein of unknown function (DUF975); Region: DUF975; cl10504 1399115003630 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1399115003631 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1399115003632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1399115003633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1399115003634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115003635 Walker A/P-loop; other site 1399115003636 ATP binding site [chemical binding]; other site 1399115003637 Q-loop/lid; other site 1399115003638 ABC transporter signature motif; other site 1399115003639 Walker B; other site 1399115003640 D-loop; other site 1399115003641 H-loop/switch region; other site 1399115003642 GAF domain; Region: GAF_3; pfam13492 1399115003643 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1399115003644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115003645 dimer interface [polypeptide binding]; other site 1399115003646 phosphorylation site [posttranslational modification] 1399115003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115003648 ATP binding site [chemical binding]; other site 1399115003649 Mg2+ binding site [ion binding]; other site 1399115003650 G-X-G motif; other site 1399115003651 GAF domain; Region: GAF; pfam01590 1399115003652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115003653 metal binding site [ion binding]; metal-binding site 1399115003654 active site 1399115003655 I-site; other site 1399115003656 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115003657 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1399115003658 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1399115003659 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1399115003660 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1399115003661 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1399115003662 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1399115003663 Zn binding site [ion binding]; other site 1399115003664 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1399115003665 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1399115003666 active site 1399115003667 dimer interface [polypeptide binding]; other site 1399115003668 Predicted membrane protein [Function unknown]; Region: COG3766 1399115003669 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1399115003670 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115003671 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115003672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115003673 metal binding site [ion binding]; metal-binding site 1399115003674 active site 1399115003675 I-site; other site 1399115003676 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1399115003677 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1399115003678 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1399115003679 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1399115003680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115003681 NAD(P) binding site [chemical binding]; other site 1399115003682 active site 1399115003683 putative acyltransferase; Provisional; Region: PRK05790 1399115003684 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1399115003685 dimer interface [polypeptide binding]; other site 1399115003686 active site 1399115003687 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1399115003688 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1399115003689 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1399115003690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1399115003691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1399115003692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1399115003693 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1399115003694 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1399115003695 intersubunit interface [polypeptide binding]; other site 1399115003696 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1399115003697 IucA / IucC family; Region: IucA_IucC; pfam04183 1399115003698 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1399115003699 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1399115003700 IucA / IucC family; Region: IucA_IucC; pfam04183 1399115003701 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1399115003702 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1399115003703 acyl-CoA synthetase; Validated; Region: PRK08308 1399115003704 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1399115003705 acyl-activating enzyme (AAE) consensus motif; other site 1399115003706 acyl-activating enzyme (AAE) consensus motif; other site 1399115003707 AMP binding site [chemical binding]; other site 1399115003708 active site 1399115003709 CoA binding site [chemical binding]; other site 1399115003710 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1399115003711 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1399115003712 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1399115003713 dimer interface [polypeptide binding]; other site 1399115003714 active site 1399115003715 metal binding site [ion binding]; metal-binding site 1399115003716 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1399115003717 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1399115003718 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115003719 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115003720 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115003721 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1399115003722 nudix motif; other site 1399115003723 short chain dehydrogenase; Provisional; Region: PRK06701 1399115003724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115003725 NAD(P) binding site [chemical binding]; other site 1399115003726 active site 1399115003727 adhesin; Provisional; Region: PRK09752 1399115003728 Predicted transcriptional regulators [Transcription]; Region: COG1725 1399115003729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115003730 DNA-binding site [nucleotide binding]; DNA binding site 1399115003731 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1399115003732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115003733 Walker A/P-loop; other site 1399115003734 ATP binding site [chemical binding]; other site 1399115003735 Q-loop/lid; other site 1399115003736 ABC transporter signature motif; other site 1399115003737 Walker B; other site 1399115003738 D-loop; other site 1399115003739 H-loop/switch region; other site 1399115003740 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1399115003741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115003742 putative substrate translocation pore; other site 1399115003743 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1399115003744 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1399115003745 active site 1399115003746 pyrophosphate binding site [ion binding]; other site 1399115003747 thiamine phosphate binding site [chemical binding]; other site 1399115003748 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1399115003749 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1399115003750 thiS-thiF/thiG interaction site; other site 1399115003751 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1399115003752 ThiS interaction site; other site 1399115003753 putative active site [active] 1399115003754 tetramer interface [polypeptide binding]; other site 1399115003755 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1399115003756 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1399115003757 ATP binding site [chemical binding]; other site 1399115003758 substrate interface [chemical binding]; other site 1399115003759 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1399115003760 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1399115003761 active site 1399115003762 metal binding site [ion binding]; metal-binding site 1399115003763 DNA binding site [nucleotide binding] 1399115003764 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1399115003765 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1399115003766 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1399115003767 Walker A/P-loop; other site 1399115003768 ATP binding site [chemical binding]; other site 1399115003769 Q-loop/lid; other site 1399115003770 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1399115003771 ABC transporter signature motif; other site 1399115003772 Walker B; other site 1399115003773 D-loop; other site 1399115003774 H-loop/switch region; other site 1399115003775 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1399115003776 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1399115003777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115003778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115003779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1399115003780 dimerization interface [polypeptide binding]; other site 1399115003781 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1399115003782 maltose O-acetyltransferase; Provisional; Region: PRK10092 1399115003783 active site 1399115003784 substrate binding site [chemical binding]; other site 1399115003785 trimer interface [polypeptide binding]; other site 1399115003786 CoA binding site [chemical binding]; other site 1399115003787 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1399115003788 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1399115003789 classical (c) SDRs; Region: SDR_c; cd05233 1399115003790 NAD(P) binding site [chemical binding]; other site 1399115003791 active site 1399115003792 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1399115003793 hypothetical protein; Provisional; Region: PRK06771 1399115003794 Nuclease-related domain; Region: NERD; pfam08378 1399115003795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115003796 MarR family; Region: MarR; pfam01047 1399115003797 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1399115003798 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1399115003799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115003800 dimerization interface [polypeptide binding]; other site 1399115003801 putative DNA binding site [nucleotide binding]; other site 1399115003802 putative Zn2+ binding site [ion binding]; other site 1399115003803 arsenical pump membrane protein; Provisional; Region: PRK15445 1399115003804 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1399115003805 transmembrane helices; other site 1399115003806 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1399115003807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115003808 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115003809 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1399115003810 active site residue [active] 1399115003811 Predicted transcriptional regulators [Transcription]; Region: COG1695 1399115003812 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1399115003813 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1399115003814 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1399115003815 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115003816 NAD(P) binding site [chemical binding]; other site 1399115003817 putative active site [active] 1399115003818 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1399115003819 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1399115003820 substrate binding pocket [chemical binding]; other site 1399115003821 membrane-bound complex binding site; other site 1399115003822 hinge residues; other site 1399115003823 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1399115003824 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1399115003825 substrate binding pocket [chemical binding]; other site 1399115003826 membrane-bound complex binding site; other site 1399115003827 hinge residues; other site 1399115003828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115003829 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1399115003830 Walker A/P-loop; other site 1399115003831 ATP binding site [chemical binding]; other site 1399115003832 Q-loop/lid; other site 1399115003833 ABC transporter signature motif; other site 1399115003834 Walker B; other site 1399115003835 D-loop; other site 1399115003836 H-loop/switch region; other site 1399115003837 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1399115003838 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1399115003839 rod shape-determining protein MreC; Provisional; Region: PRK13922 1399115003840 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1399115003841 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1399115003842 DXD motif; other site 1399115003843 Asp23 family; Region: Asp23; pfam03780 1399115003844 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 1399115003845 Asp23 family; Region: Asp23; pfam03780 1399115003846 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1399115003847 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1399115003848 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115003849 Predicted permease [General function prediction only]; Region: COG2056 1399115003850 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1399115003851 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1399115003852 active site clefts [active] 1399115003853 zinc binding site [ion binding]; other site 1399115003854 dimer interface [polypeptide binding]; other site 1399115003855 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1399115003856 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1399115003857 putative catalytic cysteine [active] 1399115003858 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1399115003859 putative active site [active] 1399115003860 metal binding site [ion binding]; metal-binding site 1399115003861 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1399115003862 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1399115003863 active site 1399115003864 metal binding site [ion binding]; metal-binding site 1399115003865 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1399115003866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115003867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115003868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1399115003869 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1399115003870 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1399115003871 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1399115003872 acetoacetate decarboxylase; Provisional; Region: PRK02265 1399115003873 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1399115003874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115003875 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1399115003876 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1399115003877 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1399115003878 cardiolipin synthetase; Reviewed; Region: PRK12452 1399115003879 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1399115003880 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1399115003881 putative active site [active] 1399115003882 catalytic site [active] 1399115003883 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1399115003884 putative active site [active] 1399115003885 catalytic site [active] 1399115003886 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1399115003887 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1399115003888 putative active site [active] 1399115003889 putative catalytic site [active] 1399115003890 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1399115003891 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1399115003892 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1399115003893 catalytic residue [active] 1399115003894 CAAX protease self-immunity; Region: Abi; pfam02517 1399115003895 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1399115003896 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115003897 Walker A/P-loop; other site 1399115003898 ATP binding site [chemical binding]; other site 1399115003899 Q-loop/lid; other site 1399115003900 ABC transporter signature motif; other site 1399115003901 Walker B; other site 1399115003902 D-loop; other site 1399115003903 H-loop/switch region; other site 1399115003904 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1399115003905 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1399115003906 Ion channel; Region: Ion_trans_2; pfam07885 1399115003907 TrkA-N domain; Region: TrkA_N; pfam02254 1399115003908 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1399115003909 active site 1399115003910 catalytic residues [active] 1399115003911 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1399115003912 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1399115003913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115003914 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1399115003915 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1399115003916 Int/Topo IB signature motif; other site 1399115003917 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 1399115003918 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1399115003919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1399115003920 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1399115003921 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115003922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115003923 non-specific DNA binding site [nucleotide binding]; other site 1399115003924 salt bridge; other site 1399115003925 sequence-specific DNA binding site [nucleotide binding]; other site 1399115003926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115003927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115003928 non-specific DNA binding site [nucleotide binding]; other site 1399115003929 salt bridge; other site 1399115003930 sequence-specific DNA binding site [nucleotide binding]; other site 1399115003931 Prophage antirepressor [Transcription]; Region: COG3617 1399115003932 BRO family, N-terminal domain; Region: Bro-N; smart01040 1399115003933 ORF6C domain; Region: ORF6C; pfam10552 1399115003934 Helix-turn-helix domain; Region: HTH_36; pfam13730 1399115003935 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1399115003936 Recombination protein U; Region: RecU; cl01314 1399115003937 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1399115003938 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1399115003939 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1399115003940 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1399115003941 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1399115003942 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1399115003943 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1399115003944 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1399115003945 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1399115003946 Phage XkdN-like protein; Region: XkdN; pfam08890 1399115003947 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1399115003948 Phage-related protein [Function unknown]; Region: COG5412 1399115003949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1399115003950 3D domain; Region: 3D; cl01439 1399115003951 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115003952 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115003953 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1399115003954 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1399115003955 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1399115003956 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1399115003957 Holin family; Region: Phage_holin_4; pfam05105 1399115003958 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1399115003959 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1399115003960 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1399115003961 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1399115003962 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1399115003963 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1399115003964 hydrophobic ligand binding site; other site 1399115003965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1399115003966 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115003967 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1399115003968 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1399115003969 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1399115003970 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1399115003971 catalytic residues [active] 1399115003972 dimer interface [polypeptide binding]; other site 1399115003973 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1399115003974 EamA-like transporter family; Region: EamA; pfam00892 1399115003975 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1399115003976 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1399115003977 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1399115003978 active site 1399115003979 nucleotide binding site [chemical binding]; other site 1399115003980 HIGH motif; other site 1399115003981 KMSKS motif; other site 1399115003982 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1399115003983 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1399115003984 putative active site [active] 1399115003985 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1399115003986 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115003987 active site turn [active] 1399115003988 phosphorylation site [posttranslational modification] 1399115003989 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115003990 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1399115003991 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1399115003992 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1399115003993 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1399115003994 dimer interface [polypeptide binding]; other site 1399115003995 Citrate synthase; Region: Citrate_synt; pfam00285 1399115003996 active site 1399115003997 citrylCoA binding site [chemical binding]; other site 1399115003998 oxalacetate/citrate binding site [chemical binding]; other site 1399115003999 coenzyme A binding site [chemical binding]; other site 1399115004000 catalytic triad [active] 1399115004001 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1399115004002 Peptidase family M50; Region: Peptidase_M50; pfam02163 1399115004003 active site 1399115004004 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1399115004005 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1399115004006 Walker A/P-loop; other site 1399115004007 ATP binding site [chemical binding]; other site 1399115004008 Q-loop/lid; other site 1399115004009 ABC transporter signature motif; other site 1399115004010 Walker B; other site 1399115004011 D-loop; other site 1399115004012 H-loop/switch region; other site 1399115004013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115004014 ABC-ATPase subunit interface; other site 1399115004015 dimer interface [polypeptide binding]; other site 1399115004016 putative PBP binding regions; other site 1399115004017 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1399115004018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115004019 ABC-ATPase subunit interface; other site 1399115004020 dimer interface [polypeptide binding]; other site 1399115004021 putative PBP binding regions; other site 1399115004022 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1399115004023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1399115004024 intersubunit interface [polypeptide binding]; other site 1399115004025 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1399115004026 GAF domain; Region: GAF; pfam01590 1399115004027 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115004028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115004029 metal binding site [ion binding]; metal-binding site 1399115004030 active site 1399115004031 I-site; other site 1399115004032 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1399115004033 PRD domain; Region: PRD; pfam00874 1399115004034 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1399115004035 active site 1399115004036 P-loop; other site 1399115004037 phosphorylation site [posttranslational modification] 1399115004038 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1399115004039 active site 1399115004040 phosphorylation site [posttranslational modification] 1399115004041 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1399115004042 active site 1399115004043 P-loop; other site 1399115004044 phosphorylation site [posttranslational modification] 1399115004045 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1399115004046 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1399115004047 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1399115004048 substrate binding site [chemical binding]; other site 1399115004049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1399115004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115004051 dimer interface [polypeptide binding]; other site 1399115004052 conserved gate region; other site 1399115004053 putative PBP binding loops; other site 1399115004054 ABC-ATPase subunit interface; other site 1399115004055 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1399115004056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115004057 dimer interface [polypeptide binding]; other site 1399115004058 conserved gate region; other site 1399115004059 putative PBP binding loops; other site 1399115004060 ABC-ATPase subunit interface; other site 1399115004061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1399115004062 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1399115004063 Walker A/P-loop; other site 1399115004064 ATP binding site [chemical binding]; other site 1399115004065 Q-loop/lid; other site 1399115004066 ABC transporter signature motif; other site 1399115004067 Walker B; other site 1399115004068 D-loop; other site 1399115004069 H-loop/switch region; other site 1399115004070 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1399115004071 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 1399115004072 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1399115004073 Walker A/P-loop; other site 1399115004074 ATP binding site [chemical binding]; other site 1399115004075 Q-loop/lid; other site 1399115004076 ABC transporter signature motif; other site 1399115004077 Walker B; other site 1399115004078 D-loop; other site 1399115004079 H-loop/switch region; other site 1399115004080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115004081 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115004082 Walker A/P-loop; other site 1399115004083 ATP binding site [chemical binding]; other site 1399115004084 Q-loop/lid; other site 1399115004085 ABC transporter signature motif; other site 1399115004086 Walker B; other site 1399115004087 D-loop; other site 1399115004088 H-loop/switch region; other site 1399115004089 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1399115004090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1399115004091 dimerization interface [polypeptide binding]; other site 1399115004092 putative DNA binding site [nucleotide binding]; other site 1399115004093 putative Zn2+ binding site [ion binding]; other site 1399115004094 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1399115004095 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1399115004096 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1399115004097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115004098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115004099 non-specific DNA binding site [nucleotide binding]; other site 1399115004100 salt bridge; other site 1399115004101 sequence-specific DNA binding site [nucleotide binding]; other site 1399115004102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115004103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115004104 Coenzyme A binding pocket [chemical binding]; other site 1399115004105 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1399115004106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1399115004107 active site 1399115004108 HIGH motif; other site 1399115004109 nucleotide binding site [chemical binding]; other site 1399115004110 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1399115004111 active site 1399115004112 KMSKS motif; other site 1399115004113 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1399115004114 tRNA binding surface [nucleotide binding]; other site 1399115004115 anticodon binding site; other site 1399115004116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115004117 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1399115004118 active site 1399115004119 catalytic triad [active] 1399115004120 dimer interface [polypeptide binding]; other site 1399115004121 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1399115004122 active site 1399115004123 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1399115004124 nudix motif; other site 1399115004125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115004126 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1399115004127 active site 1399115004128 motif I; other site 1399115004129 motif II; other site 1399115004130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115004131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1399115004132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1399115004133 DNA binding site [nucleotide binding] 1399115004134 domain linker motif; other site 1399115004135 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1399115004136 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1399115004137 active site 1399115004138 ATP binding site [chemical binding]; other site 1399115004139 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115004140 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1399115004141 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1399115004142 active site 1399115004143 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1399115004144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1399115004145 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1399115004146 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1399115004147 DinB superfamily; Region: DinB_2; pfam12867 1399115004148 DinB family; Region: DinB; cl17821 1399115004149 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1399115004150 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1399115004151 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1399115004152 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1399115004153 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1399115004154 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1399115004155 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1399115004156 pyruvate dehydrogenase; Provisional; Region: PRK06546 1399115004157 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1399115004158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115004159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115004160 serine/threonine transporter SstT; Provisional; Region: PRK13628 1399115004161 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1399115004162 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1399115004163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115004164 LysE type translocator; Region: LysE; cl00565 1399115004165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115004166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115004167 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1399115004168 dimerization interface [polypeptide binding]; other site 1399115004169 Predicted transcriptional regulators [Transcription]; Region: COG1695 1399115004170 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1399115004171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115004172 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1399115004173 Walker A/P-loop; other site 1399115004174 ATP binding site [chemical binding]; other site 1399115004175 Q-loop/lid; other site 1399115004176 ABC transporter signature motif; other site 1399115004177 Walker B; other site 1399115004178 D-loop; other site 1399115004179 H-loop/switch region; other site 1399115004180 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1399115004181 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1399115004182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1399115004183 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1399115004184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115004185 putative substrate translocation pore; other site 1399115004186 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115004187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115004188 dimerization interface [polypeptide binding]; other site 1399115004189 putative DNA binding site [nucleotide binding]; other site 1399115004190 putative Zn2+ binding site [ion binding]; other site 1399115004191 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115004192 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1399115004193 putative NAD(P) binding site [chemical binding]; other site 1399115004194 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1399115004195 putative active site [active] 1399115004196 YdjC motif; other site 1399115004197 Mg binding site [ion binding]; other site 1399115004198 putative homodimer interface [polypeptide binding]; other site 1399115004199 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1399115004200 active site 1399115004201 P-loop; other site 1399115004202 phosphorylation site [posttranslational modification] 1399115004203 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1399115004204 methionine cluster; other site 1399115004205 active site 1399115004206 phosphorylation site [posttranslational modification] 1399115004207 metal binding site [ion binding]; metal-binding site 1399115004208 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1399115004209 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1399115004210 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1399115004211 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1399115004212 NAD binding site [chemical binding]; other site 1399115004213 sugar binding site [chemical binding]; other site 1399115004214 divalent metal binding site [ion binding]; other site 1399115004215 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1399115004216 dimer interface [polypeptide binding]; other site 1399115004217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115004218 DNA-binding site [nucleotide binding]; DNA binding site 1399115004219 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1399115004220 UTRA domain; Region: UTRA; pfam07702 1399115004221 Beta-lactamase; Region: Beta-lactamase; pfam00144 1399115004222 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1399115004223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115004224 NmrA-like family; Region: NmrA; pfam05368 1399115004225 NAD(P) binding site [chemical binding]; other site 1399115004226 active site 1399115004227 Predicted transcriptional regulator [Transcription]; Region: COG1959 1399115004228 Transcriptional regulator; Region: Rrf2; pfam02082 1399115004229 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1399115004230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115004231 NAD(P) binding site [chemical binding]; other site 1399115004232 active site 1399115004233 EamA-like transporter family; Region: EamA; pfam00892 1399115004234 EamA-like transporter family; Region: EamA; cl17759 1399115004235 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115004236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115004237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115004238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115004239 putative substrate translocation pore; other site 1399115004240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115004241 dimerization interface [polypeptide binding]; other site 1399115004242 putative DNA binding site [nucleotide binding]; other site 1399115004243 putative Zn2+ binding site [ion binding]; other site 1399115004244 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1399115004245 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1399115004246 NAD(P) binding site [chemical binding]; other site 1399115004247 catalytic residues [active] 1399115004248 short chain dehydrogenase; Validated; Region: PRK06182 1399115004249 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1399115004250 NADP binding site [chemical binding]; other site 1399115004251 active site 1399115004252 steroid binding site; other site 1399115004253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115004254 H+ Antiporter protein; Region: 2A0121; TIGR00900 1399115004255 putative substrate translocation pore; other site 1399115004256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115004257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115004258 putative DNA binding site [nucleotide binding]; other site 1399115004259 putative Zn2+ binding site [ion binding]; other site 1399115004260 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1399115004261 NHL repeat; Region: NHL; pfam01436 1399115004262 NHL repeat; Region: NHL; pfam01436 1399115004263 NHL repeat; Region: NHL; pfam01436 1399115004264 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1399115004265 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115004266 NAD(P) binding site [chemical binding]; other site 1399115004267 Ion channel; Region: Ion_trans_2; pfam07885 1399115004268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115004269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115004270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1399115004271 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1399115004272 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1399115004273 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1399115004274 potential catalytic triad [active] 1399115004275 conserved cys residue [active] 1399115004276 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1399115004277 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1399115004278 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1399115004279 potential catalytic triad [active] 1399115004280 conserved cys residue [active] 1399115004281 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115004282 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115004283 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1399115004284 classical (c) SDRs; Region: SDR_c; cd05233 1399115004285 NAD(P) binding site [chemical binding]; other site 1399115004286 active site 1399115004287 MarR family; Region: MarR; pfam01047 1399115004288 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1399115004289 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115004290 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115004291 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115004292 Walker A/P-loop; other site 1399115004293 ATP binding site [chemical binding]; other site 1399115004294 Q-loop/lid; other site 1399115004295 ABC transporter signature motif; other site 1399115004296 Walker B; other site 1399115004297 D-loop; other site 1399115004298 H-loop/switch region; other site 1399115004299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1399115004300 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1399115004301 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1399115004302 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115004303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115004304 metal binding site [ion binding]; metal-binding site 1399115004305 active site 1399115004306 I-site; other site 1399115004307 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1399115004308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115004309 Walker A/P-loop; other site 1399115004310 ATP binding site [chemical binding]; other site 1399115004311 Q-loop/lid; other site 1399115004312 ABC transporter signature motif; other site 1399115004313 Walker B; other site 1399115004314 D-loop; other site 1399115004315 H-loop/switch region; other site 1399115004316 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1399115004317 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1399115004318 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1399115004319 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1399115004320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115004321 MarR family; Region: MarR_2; pfam12802 1399115004322 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115004323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115004324 dimerization interface [polypeptide binding]; other site 1399115004325 putative DNA binding site [nucleotide binding]; other site 1399115004326 putative Zn2+ binding site [ion binding]; other site 1399115004327 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1399115004328 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115004329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115004330 non-specific DNA binding site [nucleotide binding]; other site 1399115004331 salt bridge; other site 1399115004332 sequence-specific DNA binding site [nucleotide binding]; other site 1399115004333 Predicted transcriptional regulator [Transcription]; Region: COG1959 1399115004334 Transcriptional regulator; Region: Rrf2; pfam02082 1399115004335 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1399115004336 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115004337 NAD binding site [chemical binding]; other site 1399115004338 substrate binding site [chemical binding]; other site 1399115004339 putative active site [active] 1399115004340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115004342 Coenzyme A binding pocket [chemical binding]; other site 1399115004343 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1399115004344 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115004345 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1399115004346 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1399115004347 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1399115004348 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 1399115004349 NodB motif; other site 1399115004350 putative active site [active] 1399115004351 putative catalytic site [active] 1399115004352 putative Zn binding site [ion binding]; other site 1399115004353 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1399115004354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115004355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115004356 metal binding site [ion binding]; metal-binding site 1399115004357 active site 1399115004358 I-site; other site 1399115004359 Protein of unknown function (DUF402); Region: DUF402; cl00979 1399115004360 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1399115004361 nudix motif; other site 1399115004362 DinB superfamily; Region: DinB_2; pfam12867 1399115004363 Helix-turn-helix domain; Region: HTH_36; pfam13730 1399115004364 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1399115004365 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1399115004366 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1399115004367 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1399115004368 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1399115004369 Phage lysis protein, holin; Region: Phage_holin; cl04675 1399115004370 CHASE3 domain; Region: CHASE3; pfam05227 1399115004371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115004372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115004373 metal binding site [ion binding]; metal-binding site 1399115004374 active site 1399115004375 I-site; other site 1399115004376 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1399115004377 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1399115004378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115004379 catalytic residue [active] 1399115004380 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1399115004381 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1399115004382 DNA binding residues [nucleotide binding] 1399115004383 putative dimer interface [polypeptide binding]; other site 1399115004384 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1399115004385 classical (c) SDRs; Region: SDR_c; cd05233 1399115004386 NAD(P) binding site [chemical binding]; other site 1399115004387 active site 1399115004388 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1399115004389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115004390 PAS domain; Region: PAS_9; pfam13426 1399115004391 putative active site [active] 1399115004392 heme pocket [chemical binding]; other site 1399115004393 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115004394 dimer interface [polypeptide binding]; other site 1399115004395 putative CheW interface [polypeptide binding]; other site 1399115004396 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1399115004397 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1399115004398 H+ Antiporter protein; Region: 2A0121; TIGR00900 1399115004399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115004400 NAD(P) binding site [chemical binding]; other site 1399115004401 active site 1399115004402 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1399115004403 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1399115004404 heme-binding site [chemical binding]; other site 1399115004405 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1399115004406 FAD binding pocket [chemical binding]; other site 1399115004407 conserved FAD binding motif [chemical binding]; other site 1399115004408 phosphate binding motif [ion binding]; other site 1399115004409 beta-alpha-beta structure motif; other site 1399115004410 NAD binding pocket [chemical binding]; other site 1399115004411 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1399115004412 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1399115004413 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1399115004414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115004415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115004416 putative substrate translocation pore; other site 1399115004417 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115004418 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115004419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115004420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115004421 non-specific DNA binding site [nucleotide binding]; other site 1399115004422 salt bridge; other site 1399115004423 sequence-specific DNA binding site [nucleotide binding]; other site 1399115004424 hypothetical protein; Validated; Region: PRK07668 1399115004425 Predicted transcriptional regulators [Transcription]; Region: COG1695 1399115004426 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1399115004427 CAAX protease self-immunity; Region: Abi; pfam02517 1399115004428 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1399115004429 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1399115004430 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1399115004431 putative active site [active] 1399115004432 nucleotide binding site [chemical binding]; other site 1399115004433 nudix motif; other site 1399115004434 putative metal binding site [ion binding]; other site 1399115004435 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1399115004436 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1399115004437 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1399115004438 siderophore binding site; other site 1399115004439 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1399115004440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115004441 ABC-ATPase subunit interface; other site 1399115004442 dimer interface [polypeptide binding]; other site 1399115004443 putative PBP binding regions; other site 1399115004444 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1399115004445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115004446 ABC-ATPase subunit interface; other site 1399115004447 dimer interface [polypeptide binding]; other site 1399115004448 putative PBP binding regions; other site 1399115004449 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115004450 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115004451 Walker A/P-loop; other site 1399115004452 ATP binding site [chemical binding]; other site 1399115004453 Q-loop/lid; other site 1399115004454 ABC transporter signature motif; other site 1399115004455 Walker B; other site 1399115004456 D-loop; other site 1399115004457 H-loop/switch region; other site 1399115004458 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1399115004459 HCO3- transporter family; Region: HCO3_cotransp; pfam00955 1399115004460 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1399115004461 active site 1399115004462 P-loop; other site 1399115004463 phosphorylation site [posttranslational modification] 1399115004464 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1399115004465 methionine cluster; other site 1399115004466 active site 1399115004467 phosphorylation site [posttranslational modification] 1399115004468 metal binding site [ion binding]; metal-binding site 1399115004469 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1399115004470 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1399115004471 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1399115004472 beta-galactosidase; Region: BGL; TIGR03356 1399115004473 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1399115004474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115004475 DNA-binding site [nucleotide binding]; DNA binding site 1399115004476 UTRA domain; Region: UTRA; pfam07702 1399115004477 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1399115004478 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1399115004479 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 1399115004480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004481 Coenzyme A binding pocket [chemical binding]; other site 1399115004482 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1399115004483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115004484 putative metal binding site [ion binding]; other site 1399115004485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115004486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115004487 putative substrate translocation pore; other site 1399115004488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1399115004489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1399115004490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115004491 PAS domain; Region: PAS_9; pfam13426 1399115004492 putative active site [active] 1399115004493 heme pocket [chemical binding]; other site 1399115004494 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1399115004495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115004496 dimer interface [polypeptide binding]; other site 1399115004497 putative CheW interface [polypeptide binding]; other site 1399115004498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115004499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004500 Coenzyme A binding pocket [chemical binding]; other site 1399115004501 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115004502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115004503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004504 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115004505 Coenzyme A binding pocket [chemical binding]; other site 1399115004506 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1399115004507 active site 1399115004508 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1399115004509 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1399115004510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1399115004511 dimerization interface [polypeptide binding]; other site 1399115004512 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115004513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115004514 dimer interface [polypeptide binding]; other site 1399115004515 putative CheW interface [polypeptide binding]; other site 1399115004516 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115004517 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115004518 topology modulation protein; Reviewed; Region: PRK08118 1399115004519 AAA domain; Region: AAA_17; pfam13207 1399115004520 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1399115004521 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 1399115004522 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1399115004523 putative dimer interface [polypeptide binding]; other site 1399115004524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115004525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115004526 MarR family; Region: MarR_2; pfam12802 1399115004527 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1399115004528 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115004529 Coenzyme A binding pocket [chemical binding]; other site 1399115004530 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1399115004531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1399115004532 YusW-like protein; Region: YusW; pfam14039 1399115004533 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1399115004534 putative catalytic site [active] 1399115004535 putative metal binding site [ion binding]; other site 1399115004536 putative phosphate binding site [ion binding]; other site 1399115004537 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115004538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004539 Coenzyme A binding pocket [chemical binding]; other site 1399115004540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004541 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115004542 Coenzyme A binding pocket [chemical binding]; other site 1399115004543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115004544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115004545 non-specific DNA binding site [nucleotide binding]; other site 1399115004546 salt bridge; other site 1399115004547 sequence-specific DNA binding site [nucleotide binding]; other site 1399115004548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115004549 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1399115004550 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1399115004551 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1399115004552 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1399115004553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115004554 motif II; other site 1399115004555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115004556 putative substrate translocation pore; other site 1399115004557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115004558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115004559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115004560 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1399115004561 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1399115004562 Domain of unknown function DUF21; Region: DUF21; pfam01595 1399115004563 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1399115004564 Transporter associated domain; Region: CorC_HlyC; smart01091 1399115004565 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1399115004566 heme-binding site [chemical binding]; other site 1399115004567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115004568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115004569 dimer interface [polypeptide binding]; other site 1399115004570 putative CheW interface [polypeptide binding]; other site 1399115004571 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1399115004572 active site 1399115004573 substrate binding site [chemical binding]; other site 1399115004574 ATP binding site [chemical binding]; other site 1399115004575 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1399115004576 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1399115004577 active site 1399115004578 Zn binding site [ion binding]; other site 1399115004579 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1399115004580 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1399115004581 active site 1399115004582 catalytic site [active] 1399115004583 metal binding site [ion binding]; metal-binding site 1399115004584 dimer interface [polypeptide binding]; other site 1399115004585 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1399115004586 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1399115004587 catalytic site [active] 1399115004588 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1399115004589 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115004590 active site 1399115004591 substrate binding site [chemical binding]; other site 1399115004592 ATP binding site [chemical binding]; other site 1399115004593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1399115004594 TPR motif; other site 1399115004595 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1399115004596 binding surface 1399115004597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115004598 MarR family; Region: MarR; pfam01047 1399115004599 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1399115004600 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1399115004601 MarR family; Region: MarR; pfam01047 1399115004602 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1399115004603 Predicted membrane protein [Function unknown]; Region: COG3428 1399115004604 Bacterial PH domain; Region: DUF304; pfam03703 1399115004605 Bacterial PH domain; Region: DUF304; pfam03703 1399115004606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115004607 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1399115004608 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1399115004609 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1399115004610 TrkA-C domain; Region: TrkA_C; pfam02080 1399115004611 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1399115004612 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1399115004613 putative NAD(P) binding site [chemical binding]; other site 1399115004614 active site 1399115004615 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115004616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004617 Coenzyme A binding pocket [chemical binding]; other site 1399115004618 putative oxidoreductase; Provisional; Region: PRK10206 1399115004619 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1399115004620 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1399115004621 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115004622 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115004623 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1399115004624 putative active site [active] 1399115004625 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1399115004626 Imelysin; Region: Peptidase_M75; pfam09375 1399115004627 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1399115004628 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1399115004629 Cytochrome b562; Region: Cytochrom_B562; cl01546 1399115004630 Iron permease FTR1 family; Region: FTR1; cl00475 1399115004631 Heat induced stress protein YflT; Region: YflT; pfam11181 1399115004632 YCII-related domain; Region: YCII; cl00999 1399115004633 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1399115004634 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1399115004635 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1399115004636 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1399115004637 TAP-like protein; Region: Abhydrolase_4; pfam08386 1399115004638 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1399115004639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115004640 NAD(P) binding site [chemical binding]; other site 1399115004641 active site 1399115004642 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115004643 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115004644 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1399115004645 Protein of unknown function DUF58; Region: DUF58; pfam01882 1399115004646 MoxR-like ATPases [General function prediction only]; Region: COG0714 1399115004647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115004648 Walker A motif; other site 1399115004649 ATP binding site [chemical binding]; other site 1399115004650 Walker B motif; other site 1399115004651 arginine finger; other site 1399115004652 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1399115004653 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1399115004654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115004655 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1399115004656 catalytic core [active] 1399115004657 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 1399115004658 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1399115004659 nudix motif; other site 1399115004660 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1399115004661 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1399115004662 CAP-like domain; other site 1399115004663 active site 1399115004664 primary dimer interface [polypeptide binding]; other site 1399115004665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115004666 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115004667 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1399115004668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115004669 ATP binding site [chemical binding]; other site 1399115004670 Mg2+ binding site [ion binding]; other site 1399115004671 G-X-G motif; other site 1399115004672 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1399115004673 anchoring element; other site 1399115004674 dimer interface [polypeptide binding]; other site 1399115004675 ATP binding site [chemical binding]; other site 1399115004676 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1399115004677 active site 1399115004678 putative metal-binding site [ion binding]; other site 1399115004679 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1399115004680 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1399115004681 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1399115004682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1399115004683 active site 1399115004684 DNA binding site [nucleotide binding] 1399115004685 Int/Topo IB signature motif; other site 1399115004686 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1399115004687 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1399115004688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115004689 ATP binding site [chemical binding]; other site 1399115004690 putative Mg++ binding site [ion binding]; other site 1399115004691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115004692 nucleotide binding region [chemical binding]; other site 1399115004693 ATP-binding site [chemical binding]; other site 1399115004694 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 1399115004695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115004696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1399115004697 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1399115004698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115004699 catalytic residue [active] 1399115004700 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1399115004701 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1399115004702 5S rRNA interface [nucleotide binding]; other site 1399115004703 CTC domain interface [polypeptide binding]; other site 1399115004704 L16 interface [polypeptide binding]; other site 1399115004705 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1399115004706 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115004707 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1399115004708 Walker A/P-loop; other site 1399115004709 ATP binding site [chemical binding]; other site 1399115004710 Q-loop/lid; other site 1399115004711 ABC transporter signature motif; other site 1399115004712 Walker B; other site 1399115004713 D-loop; other site 1399115004714 H-loop/switch region; other site 1399115004715 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115004716 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1399115004717 Walker A/P-loop; other site 1399115004718 ATP binding site [chemical binding]; other site 1399115004719 Q-loop/lid; other site 1399115004720 ABC transporter signature motif; other site 1399115004721 Walker B; other site 1399115004722 D-loop; other site 1399115004723 H-loop/switch region; other site 1399115004724 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1399115004725 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1399115004726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115004727 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1399115004728 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1399115004729 TAP-like protein; Region: Abhydrolase_4; pfam08386 1399115004730 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1399115004731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004732 Coenzyme A binding pocket [chemical binding]; other site 1399115004733 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1399115004734 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1399115004735 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1399115004736 metal binding triad [ion binding]; metal-binding site 1399115004737 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1399115004738 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1399115004739 catalytic residues [active] 1399115004740 catalytic nucleophile [active] 1399115004741 Presynaptic Site I dimer interface [polypeptide binding]; other site 1399115004742 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1399115004743 Synaptic Flat tetramer interface [polypeptide binding]; other site 1399115004744 Synaptic Site I dimer interface [polypeptide binding]; other site 1399115004745 DNA binding site [nucleotide binding] 1399115004746 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1399115004747 DNA-binding interface [nucleotide binding]; DNA binding site 1399115004748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115004749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115004750 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1399115004751 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1399115004752 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1399115004753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1399115004754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1399115004755 Walker A/P-loop; other site 1399115004756 ATP binding site [chemical binding]; other site 1399115004757 Q-loop/lid; other site 1399115004758 ABC transporter signature motif; other site 1399115004759 Walker B; other site 1399115004760 D-loop; other site 1399115004761 H-loop/switch region; other site 1399115004762 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1399115004763 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1399115004764 Walker A/P-loop; other site 1399115004765 ATP binding site [chemical binding]; other site 1399115004766 Q-loop/lid; other site 1399115004767 ABC transporter signature motif; other site 1399115004768 Walker B; other site 1399115004769 D-loop; other site 1399115004770 H-loop/switch region; other site 1399115004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115004772 dimer interface [polypeptide binding]; other site 1399115004773 conserved gate region; other site 1399115004774 putative PBP binding loops; other site 1399115004775 ABC-ATPase subunit interface; other site 1399115004776 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1399115004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115004778 dimer interface [polypeptide binding]; other site 1399115004779 conserved gate region; other site 1399115004780 putative PBP binding loops; other site 1399115004781 ABC-ATPase subunit interface; other site 1399115004782 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1399115004783 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1399115004784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115004785 PAS domain; Region: PAS_9; pfam13426 1399115004786 putative active site [active] 1399115004787 heme pocket [chemical binding]; other site 1399115004788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115004789 dimer interface [polypeptide binding]; other site 1399115004790 putative CheW interface [polypeptide binding]; other site 1399115004791 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1399115004792 classical (c) SDRs; Region: SDR_c; cd05233 1399115004793 NAD(P) binding site [chemical binding]; other site 1399115004794 active site 1399115004795 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1399115004796 Asp23 family; Region: Asp23; pfam03780 1399115004797 Asp23 family; Region: Asp23; pfam03780 1399115004798 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1399115004799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115004800 NAD(P) binding site [chemical binding]; other site 1399115004801 active site 1399115004802 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1399115004803 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1399115004804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115004805 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115004806 Walker A/P-loop; other site 1399115004807 ATP binding site [chemical binding]; other site 1399115004808 Q-loop/lid; other site 1399115004809 ABC transporter signature motif; other site 1399115004810 Walker B; other site 1399115004811 D-loop; other site 1399115004812 H-loop/switch region; other site 1399115004813 PAS domain; Region: PAS_9; pfam13426 1399115004814 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1399115004815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115004816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115004817 metal binding site [ion binding]; metal-binding site 1399115004818 active site 1399115004819 I-site; other site 1399115004820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115004821 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1399115004822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115004823 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1399115004824 catalytic site [active] 1399115004825 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1399115004826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115004827 motif II; other site 1399115004828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004829 Coenzyme A binding pocket [chemical binding]; other site 1399115004830 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1399115004831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115004832 Coenzyme A binding pocket [chemical binding]; other site 1399115004833 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1399115004834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115004835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115004836 DNA binding residues [nucleotide binding] 1399115004837 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1399115004838 Beta-lactamase; Region: Beta-lactamase; pfam00144 1399115004839 TIR domain; Region: TIR_2; pfam13676 1399115004840 Predicted kinase [General function prediction only]; Region: COG0645 1399115004841 AAA domain; Region: AAA_17; pfam13207 1399115004842 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1399115004843 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115004844 active site 1399115004845 substrate binding site [chemical binding]; other site 1399115004846 ATP binding site [chemical binding]; other site 1399115004847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1399115004848 substrate binding site [chemical binding]; other site 1399115004849 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1399115004850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115004851 dimerization interface [polypeptide binding]; other site 1399115004852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115004853 dimer interface [polypeptide binding]; other site 1399115004854 phosphorylation site [posttranslational modification] 1399115004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115004856 ATP binding site [chemical binding]; other site 1399115004857 Mg2+ binding site [ion binding]; other site 1399115004858 G-X-G motif; other site 1399115004859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115004860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115004861 active site 1399115004862 phosphorylation site [posttranslational modification] 1399115004863 intermolecular recognition site; other site 1399115004864 dimerization interface [polypeptide binding]; other site 1399115004865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115004866 DNA binding site [nucleotide binding] 1399115004867 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1399115004868 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1399115004869 FtsX-like permease family; Region: FtsX; pfam02687 1399115004870 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115004871 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115004872 Walker A/P-loop; other site 1399115004873 ATP binding site [chemical binding]; other site 1399115004874 Q-loop/lid; other site 1399115004875 ABC transporter signature motif; other site 1399115004876 Walker B; other site 1399115004877 D-loop; other site 1399115004878 H-loop/switch region; other site 1399115004879 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1399115004880 HlyD family secretion protein; Region: HlyD_3; pfam13437 1399115004881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115004882 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115004883 Walker A/P-loop; other site 1399115004884 ATP binding site [chemical binding]; other site 1399115004885 Q-loop/lid; other site 1399115004886 ABC transporter signature motif; other site 1399115004887 Walker B; other site 1399115004888 D-loop; other site 1399115004889 H-loop/switch region; other site 1399115004890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1399115004891 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1399115004892 FtsX-like permease family; Region: FtsX; pfam02687 1399115004893 FtsX-like permease family; Region: FtsX; pfam02687 1399115004894 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1399115004895 nudix motif; other site 1399115004896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1399115004897 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1399115004898 FtsX-like permease family; Region: FtsX; pfam02687 1399115004899 FtsX-like permease family; Region: FtsX; pfam02687 1399115004900 hypothetical protein; Validated; Region: PRK06769 1399115004901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115004902 active site 1399115004903 motif I; other site 1399115004904 motif II; other site 1399115004905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115004906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115004907 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1399115004908 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1399115004909 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115004910 Walker A/P-loop; other site 1399115004911 ATP binding site [chemical binding]; other site 1399115004912 Q-loop/lid; other site 1399115004913 ABC transporter signature motif; other site 1399115004914 Walker B; other site 1399115004915 D-loop; other site 1399115004916 H-loop/switch region; other site 1399115004917 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1399115004918 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1399115004919 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 1399115004920 Predicted flavoprotein [General function prediction only]; Region: COG0431 1399115004921 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1399115004922 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1399115004923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115004924 Zn binding site [ion binding]; other site 1399115004925 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1399115004926 Zn binding site [ion binding]; other site 1399115004927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115004928 MarR family; Region: MarR; pfam01047 1399115004929 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1399115004930 dimer interface [polypeptide binding]; other site 1399115004931 FMN binding site [chemical binding]; other site 1399115004932 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115004933 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115004934 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1399115004935 active site 1399115004936 metal binding site [ion binding]; metal-binding site 1399115004937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115004938 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1399115004939 catalytic triad [active] 1399115004940 active site nucleophile [active] 1399115004941 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1399115004942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115004943 putative DNA binding site [nucleotide binding]; other site 1399115004944 putative Zn2+ binding site [ion binding]; other site 1399115004945 AsnC family; Region: AsnC_trans_reg; pfam01037 1399115004946 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1399115004947 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1399115004948 Predicted transcriptional regulators [Transcription]; Region: COG1695 1399115004949 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1399115004950 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1399115004951 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1399115004952 catalytic core [active] 1399115004953 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1399115004954 conserved cys residue [active] 1399115004955 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1399115004956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115004957 Walker A/P-loop; other site 1399115004958 ATP binding site [chemical binding]; other site 1399115004959 Q-loop/lid; other site 1399115004960 ABC transporter signature motif; other site 1399115004961 Walker B; other site 1399115004962 D-loop; other site 1399115004963 H-loop/switch region; other site 1399115004964 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 1399115004965 putative hydrophobic ligand binding site [chemical binding]; other site 1399115004966 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1399115004967 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1399115004968 catalytic core [active] 1399115004969 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1399115004970 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1399115004971 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1399115004972 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115004973 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1399115004974 NAD(P) binding site [chemical binding]; other site 1399115004975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1399115004976 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1399115004977 FtsX-like permease family; Region: FtsX; pfam02687 1399115004978 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115004979 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115004980 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1399115004981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1399115004982 FtsX-like permease family; Region: FtsX; pfam02687 1399115004983 FtsX-like permease family; Region: FtsX; pfam02687 1399115004984 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115004985 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115004986 Walker A/P-loop; other site 1399115004987 ATP binding site [chemical binding]; other site 1399115004988 Q-loop/lid; other site 1399115004989 ABC transporter signature motif; other site 1399115004990 Walker B; other site 1399115004991 D-loop; other site 1399115004992 H-loop/switch region; other site 1399115004993 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1399115004994 active site 1399115004995 catalytic motif [active] 1399115004996 Zn binding site [ion binding]; other site 1399115004997 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1399115004998 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 1399115004999 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1399115005000 Walker A/P-loop; other site 1399115005001 ATP binding site [chemical binding]; other site 1399115005002 Q-loop/lid; other site 1399115005003 ABC transporter signature motif; other site 1399115005004 Walker B; other site 1399115005005 D-loop; other site 1399115005006 H-loop/switch region; other site 1399115005007 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1399115005008 nudix motif; other site 1399115005009 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1399115005010 Zn binding site [ion binding]; other site 1399115005011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005012 non-specific DNA binding site [nucleotide binding]; other site 1399115005013 salt bridge; other site 1399115005014 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005015 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1399115005016 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1399115005017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115005018 NAD(P) binding site [chemical binding]; other site 1399115005019 active site 1399115005020 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115005021 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1399115005022 active site 1399115005023 ATP binding site [chemical binding]; other site 1399115005024 substrate binding site [chemical binding]; other site 1399115005025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115005026 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1399115005027 active site 1399115005028 metal binding site [ion binding]; metal-binding site 1399115005029 Predicted transcriptional regulators [Transcription]; Region: COG1695 1399115005030 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1399115005031 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1399115005032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005033 non-specific DNA binding site [nucleotide binding]; other site 1399115005034 salt bridge; other site 1399115005035 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005036 hypothetical protein; Provisional; Region: PRK09272 1399115005037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115005038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115005039 putative DNA binding site [nucleotide binding]; other site 1399115005040 putative Zn2+ binding site [ion binding]; other site 1399115005041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1399115005042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115005043 S-adenosylmethionine binding site [chemical binding]; other site 1399115005044 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 1399115005045 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1399115005046 putative hydrophobic ligand binding site [chemical binding]; other site 1399115005047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115005048 dimerization interface [polypeptide binding]; other site 1399115005049 putative DNA binding site [nucleotide binding]; other site 1399115005050 putative Zn2+ binding site [ion binding]; other site 1399115005051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115005052 NAD(P) binding site [chemical binding]; other site 1399115005053 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1399115005054 active site 1399115005055 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1399115005056 putative active site [active] 1399115005057 succinic semialdehyde dehydrogenase; Region: PLN02278 1399115005058 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1399115005059 tetramerization interface [polypeptide binding]; other site 1399115005060 NAD(P) binding site [chemical binding]; other site 1399115005061 catalytic residues [active] 1399115005062 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1399115005063 nudix motif; other site 1399115005064 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1399115005065 HTH domain; Region: HTH_11; pfam08279 1399115005066 WYL domain; Region: WYL; pfam13280 1399115005067 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1399115005068 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1399115005069 folate binding site [chemical binding]; other site 1399115005070 NADP+ binding site [chemical binding]; other site 1399115005071 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1399115005072 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1399115005073 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1399115005074 TrkA-C domain; Region: TrkA_C; pfam02080 1399115005075 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1399115005076 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1399115005077 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1399115005078 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1399115005079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115005080 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115005081 H+ Antiporter protein; Region: 2A0121; TIGR00900 1399115005082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115005083 putative substrate translocation pore; other site 1399115005084 Protein of unknown function (DUF402); Region: DUF402; cl00979 1399115005085 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1399115005086 beta-galactosidase; Region: BGL; TIGR03356 1399115005087 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1399115005088 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115005089 active site turn [active] 1399115005090 phosphorylation site [posttranslational modification] 1399115005091 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115005092 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1399115005093 HPr interaction site; other site 1399115005094 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1399115005095 active site 1399115005096 phosphorylation site [posttranslational modification] 1399115005097 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1399115005098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115005099 DNA-binding site [nucleotide binding]; DNA binding site 1399115005100 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1399115005101 proline/glycine betaine transporter; Provisional; Region: PRK10642 1399115005102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115005103 putative substrate translocation pore; other site 1399115005104 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1399115005105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115005106 motif II; other site 1399115005107 hypothetical protein; Provisional; Region: PRK06762 1399115005108 AAA domain; Region: AAA_33; pfam13671 1399115005109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115005110 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115005111 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1399115005112 active site 1399115005113 Predicted transcriptional regulator [Transcription]; Region: COG1959 1399115005114 Transcriptional regulator; Region: Rrf2; pfam02082 1399115005115 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1399115005116 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1399115005117 classical (c) SDRs; Region: SDR_c; cd05233 1399115005118 NAD(P) binding site [chemical binding]; other site 1399115005119 active site 1399115005120 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1399115005121 nudix motif; other site 1399115005122 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1399115005123 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115005124 putative hydrolase; Provisional; Region: PRK11460 1399115005125 RDD family; Region: RDD; pfam06271 1399115005126 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1399115005127 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1399115005128 putative NAD(P) binding site [chemical binding]; other site 1399115005129 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1399115005130 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1399115005131 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1399115005132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1399115005133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1399115005134 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1399115005135 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1399115005136 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1399115005137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115005138 NAD(P) binding site [chemical binding]; other site 1399115005139 active site 1399115005140 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1399115005141 Dynamin family; Region: Dynamin_N; pfam00350 1399115005142 G1 box; other site 1399115005143 GTP/Mg2+ binding site [chemical binding]; other site 1399115005144 G2 box; other site 1399115005145 Switch I region; other site 1399115005146 G3 box; other site 1399115005147 Switch II region; other site 1399115005148 G4 box; other site 1399115005149 G5 box; other site 1399115005150 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1399115005151 Dynamin family; Region: Dynamin_N; pfam00350 1399115005152 G1 box; other site 1399115005153 GTP/Mg2+ binding site [chemical binding]; other site 1399115005154 G2 box; other site 1399115005155 Switch I region; other site 1399115005156 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1399115005157 G3 box; other site 1399115005158 Switch II region; other site 1399115005159 GTP/Mg2+ binding site [chemical binding]; other site 1399115005160 G4 box; other site 1399115005161 G5 box; other site 1399115005162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115005163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115005164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1399115005165 dimerization interface [polypeptide binding]; other site 1399115005166 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1399115005167 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1399115005168 oligomer interface [polypeptide binding]; other site 1399115005169 metal binding site [ion binding]; metal-binding site 1399115005170 metal binding site [ion binding]; metal-binding site 1399115005171 putative Cl binding site [ion binding]; other site 1399115005172 aspartate ring; other site 1399115005173 basic sphincter; other site 1399115005174 hydrophobic gate; other site 1399115005175 periplasmic entrance; other site 1399115005176 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1399115005177 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1399115005178 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1399115005179 putative tRNA-binding site [nucleotide binding]; other site 1399115005180 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1399115005181 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1399115005182 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1399115005183 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1399115005184 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1399115005185 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1399115005186 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1399115005187 active site 1399115005188 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1399115005189 nudix motif; other site 1399115005190 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115005191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115005192 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115005193 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1399115005194 DNA-binding site [nucleotide binding]; DNA binding site 1399115005195 RNA-binding motif; other site 1399115005196 SnoaL-like domain; Region: SnoaL_3; pfam13474 1399115005197 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1399115005198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115005199 catalytic residue [active] 1399115005200 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1399115005201 putative ligand binding site [chemical binding]; other site 1399115005202 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1399115005203 putative NAD binding site [chemical binding]; other site 1399115005204 putative catalytic site [active] 1399115005205 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1399115005206 L-serine binding site [chemical binding]; other site 1399115005207 ACT domain interface; other site 1399115005208 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1399115005209 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1399115005210 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1399115005211 homodimer interface [polypeptide binding]; other site 1399115005212 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1399115005213 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1399115005214 active site 1399115005215 homodimer interface [polypeptide binding]; other site 1399115005216 catalytic site [active] 1399115005217 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1399115005218 hypothetical protein; Provisional; Region: PRK12378 1399115005219 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1399115005220 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1399115005221 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1399115005222 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1399115005223 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1399115005224 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1399115005225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1399115005226 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1399115005227 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1399115005228 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1399115005229 Transcriptional regulator; Region: Rrf2; cl17282 1399115005230 Predicted transcriptional regulator [Transcription]; Region: COG1959 1399115005231 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1399115005232 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1399115005233 active site 1399115005234 catalytic site [active] 1399115005235 metal binding site [ion binding]; metal-binding site 1399115005236 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1399115005237 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1399115005238 E3 interaction surface; other site 1399115005239 lipoyl attachment site [posttranslational modification]; other site 1399115005240 e3 binding domain; Region: E3_binding; pfam02817 1399115005241 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1399115005242 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1399115005243 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1399115005244 TPP-binding site [chemical binding]; other site 1399115005245 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1399115005246 dimer interface [polypeptide binding]; other site 1399115005247 PYR/PP interface [polypeptide binding]; other site 1399115005248 TPP binding site [chemical binding]; other site 1399115005249 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1399115005250 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1399115005251 Walker A/P-loop; other site 1399115005252 ATP binding site [chemical binding]; other site 1399115005253 Q-loop/lid; other site 1399115005254 ABC transporter signature motif; other site 1399115005255 Walker B; other site 1399115005256 D-loop; other site 1399115005257 H-loop/switch region; other site 1399115005258 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1399115005259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115005260 dimer interface [polypeptide binding]; other site 1399115005261 conserved gate region; other site 1399115005262 putative PBP binding loops; other site 1399115005263 ABC-ATPase subunit interface; other site 1399115005264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1399115005265 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1399115005266 substrate binding pocket [chemical binding]; other site 1399115005267 membrane-bound complex binding site; other site 1399115005268 hinge residues; other site 1399115005269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1399115005270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115005271 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1399115005272 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1399115005273 putative dimer interface [polypeptide binding]; other site 1399115005274 catalytic triad [active] 1399115005275 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1399115005276 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1399115005277 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1399115005278 NAD(P) binding site [chemical binding]; other site 1399115005279 catalytic residues [active] 1399115005280 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1399115005281 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1399115005282 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1399115005283 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1399115005284 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1399115005285 active site 1399115005286 phosphorylation site [posttranslational modification] 1399115005287 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1399115005288 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1399115005289 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1399115005290 active site 1399115005291 P-loop; other site 1399115005292 phosphorylation site [posttranslational modification] 1399115005293 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1399115005294 HTH domain; Region: HTH_11; pfam08279 1399115005295 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1399115005296 active site 1399115005297 P-loop; other site 1399115005298 phosphorylation site [posttranslational modification] 1399115005299 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1399115005300 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1399115005301 active site 1399115005302 P-loop; other site 1399115005303 phosphorylation site [posttranslational modification] 1399115005304 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1399115005305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115005306 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1399115005307 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1399115005308 active site 1399115005309 dimer interface [polypeptide binding]; other site 1399115005310 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1399115005311 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1399115005312 active site 1399115005313 FMN binding site [chemical binding]; other site 1399115005314 substrate binding site [chemical binding]; other site 1399115005315 3Fe-4S cluster binding site [ion binding]; other site 1399115005316 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1399115005317 domain interface; other site 1399115005318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1399115005319 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1399115005320 substrate binding pocket [chemical binding]; other site 1399115005321 membrane-bound complex binding site; other site 1399115005322 hinge residues; other site 1399115005323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115005324 dimer interface [polypeptide binding]; other site 1399115005325 conserved gate region; other site 1399115005326 putative PBP binding loops; other site 1399115005327 ABC-ATPase subunit interface; other site 1399115005328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115005329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115005330 metal binding site [ion binding]; metal-binding site 1399115005331 active site 1399115005332 I-site; other site 1399115005333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115005334 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1399115005335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005336 non-specific DNA binding site [nucleotide binding]; other site 1399115005337 salt bridge; other site 1399115005338 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115005340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005341 non-specific DNA binding site [nucleotide binding]; other site 1399115005342 salt bridge; other site 1399115005343 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115005345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005346 non-specific DNA binding site [nucleotide binding]; other site 1399115005347 salt bridge; other site 1399115005348 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115005350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005351 non-specific DNA binding site [nucleotide binding]; other site 1399115005352 salt bridge; other site 1399115005353 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005354 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115005355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115005356 non-specific DNA binding site [nucleotide binding]; other site 1399115005357 salt bridge; other site 1399115005358 sequence-specific DNA binding site [nucleotide binding]; other site 1399115005359 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1399115005360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1399115005361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115005362 homodimer interface [polypeptide binding]; other site 1399115005363 catalytic residue [active] 1399115005364 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1399115005365 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1399115005366 Na binding site [ion binding]; other site 1399115005367 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1399115005368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115005369 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1399115005370 PilZ domain; Region: PilZ; pfam07238 1399115005371 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1399115005372 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1399115005373 Ca binding site [ion binding]; other site 1399115005374 active site 1399115005375 catalytic site [active] 1399115005376 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1399115005377 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1399115005378 dimerization interface [polypeptide binding]; other site 1399115005379 active site 1399115005380 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1399115005381 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1399115005382 folate binding site [chemical binding]; other site 1399115005383 NADP+ binding site [chemical binding]; other site 1399115005384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115005385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115005386 metal binding site [ion binding]; metal-binding site 1399115005387 active site 1399115005388 I-site; other site 1399115005389 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1399115005390 Class II fumarases; Region: Fumarase_classII; cd01362 1399115005391 active site 1399115005392 tetramer interface [polypeptide binding]; other site 1399115005393 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1399115005394 RNA/DNA hybrid binding site [nucleotide binding]; other site 1399115005395 active site 1399115005396 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1399115005397 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1399115005398 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1399115005399 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1399115005400 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1399115005401 generic binding surface II; other site 1399115005402 generic binding surface I; other site 1399115005403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115005404 Zn2+ binding site [ion binding]; other site 1399115005405 Mg2+ binding site [ion binding]; other site 1399115005406 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1399115005407 active site 1399115005408 Zn binding site [ion binding]; other site 1399115005409 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1399115005410 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1399115005411 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1399115005412 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1399115005413 Na2 binding site [ion binding]; other site 1399115005414 putative substrate binding site 1 [chemical binding]; other site 1399115005415 Na binding site 1 [ion binding]; other site 1399115005416 putative substrate binding site 2 [chemical binding]; other site 1399115005417 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1399115005418 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1399115005419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115005420 dimer interface [polypeptide binding]; other site 1399115005421 conserved gate region; other site 1399115005422 ABC-ATPase subunit interface; other site 1399115005423 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1399115005424 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1399115005425 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1399115005426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1399115005427 Walker A/P-loop; other site 1399115005428 ATP binding site [chemical binding]; other site 1399115005429 Q-loop/lid; other site 1399115005430 ABC transporter signature motif; other site 1399115005431 Walker B; other site 1399115005432 D-loop; other site 1399115005433 H-loop/switch region; other site 1399115005434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1399115005435 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1399115005436 putative active site [active] 1399115005437 putative CoA binding site [chemical binding]; other site 1399115005438 nudix motif; other site 1399115005439 metal binding site [ion binding]; metal-binding site 1399115005440 YvfG protein; Region: YvfG; pfam09628 1399115005441 hypothetical protein; Provisional; Region: PRK06184 1399115005442 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1399115005443 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1399115005444 DivIVA protein; Region: DivIVA; pfam05103 1399115005445 DivIVA domain; Region: DivI1A_domain; TIGR03544 1399115005446 hypothetical protein; Provisional; Region: PRK13660 1399115005447 RNase_H superfamily; Region: RNase_H_2; pfam13482 1399115005448 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1399115005449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115005450 ATP binding site [chemical binding]; other site 1399115005451 putative Mg++ binding site [ion binding]; other site 1399115005452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115005453 nucleotide binding region [chemical binding]; other site 1399115005454 ATP-binding site [chemical binding]; other site 1399115005455 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1399115005456 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1399115005457 Transglycosylase; Region: Transgly; pfam00912 1399115005458 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1399115005459 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1399115005460 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1399115005461 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1399115005462 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1399115005463 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1399115005464 minor groove reading motif; other site 1399115005465 helix-hairpin-helix signature motif; other site 1399115005466 substrate binding pocket [chemical binding]; other site 1399115005467 active site 1399115005468 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1399115005469 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1399115005470 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1399115005471 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1399115005472 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1399115005473 putative dimer interface [polypeptide binding]; other site 1399115005474 putative anticodon binding site; other site 1399115005475 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1399115005476 homodimer interface [polypeptide binding]; other site 1399115005477 motif 1; other site 1399115005478 motif 2; other site 1399115005479 active site 1399115005480 motif 3; other site 1399115005481 aspartate aminotransferase; Provisional; Region: PRK05764 1399115005482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1399115005483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115005484 homodimer interface [polypeptide binding]; other site 1399115005485 catalytic residue [active] 1399115005486 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1399115005487 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1399115005488 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1399115005489 active site 1399115005490 catalytic site [active] 1399115005491 substrate binding site [chemical binding]; other site 1399115005492 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1399115005493 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1399115005494 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1399115005495 tetramerization interface [polypeptide binding]; other site 1399115005496 active site 1399115005497 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1399115005498 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1399115005499 active site 1399115005500 ATP-binding site [chemical binding]; other site 1399115005501 pantoate-binding site; other site 1399115005502 HXXH motif; other site 1399115005503 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1399115005504 active site 1399115005505 oligomerization interface [polypeptide binding]; other site 1399115005506 metal binding site [ion binding]; metal-binding site 1399115005507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115005508 dimerization interface [polypeptide binding]; other site 1399115005509 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1399115005510 putative DNA binding site [nucleotide binding]; other site 1399115005511 putative Zn2+ binding site [ion binding]; other site 1399115005512 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1399115005513 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1399115005514 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1399115005515 active site 1399115005516 NTP binding site [chemical binding]; other site 1399115005517 metal binding triad [ion binding]; metal-binding site 1399115005518 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1399115005519 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1399115005520 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1399115005521 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1399115005522 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115005523 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115005524 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115005525 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115005526 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1399115005527 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 1399115005528 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1399115005529 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1399115005530 cytochrome b6; Provisional; Region: PRK03735 1399115005531 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1399115005532 interchain domain interface [polypeptide binding]; other site 1399115005533 intrachain domain interface; other site 1399115005534 heme bH binding site [chemical binding]; other site 1399115005535 Qi binding site; other site 1399115005536 heme bL binding site [chemical binding]; other site 1399115005537 Qo binding site; other site 1399115005538 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1399115005539 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1399115005540 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1399115005541 iron-sulfur cluster [ion binding]; other site 1399115005542 [2Fe-2S] cluster binding site [ion binding]; other site 1399115005543 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1399115005544 hypothetical protein; Provisional; Region: PRK03636 1399115005545 UPF0302 domain; Region: UPF0302; pfam08864 1399115005546 IDEAL domain; Region: IDEAL; pfam08858 1399115005547 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1399115005548 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1399115005549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1399115005550 TPR motif; other site 1399115005551 binding surface 1399115005552 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1399115005553 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1399115005554 hinge; other site 1399115005555 active site 1399115005556 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1399115005557 active site 1399115005558 dimer interface [polypeptide binding]; other site 1399115005559 metal binding site [ion binding]; metal-binding site 1399115005560 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1399115005561 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1399115005562 Tetramer interface [polypeptide binding]; other site 1399115005563 active site 1399115005564 FMN-binding site [chemical binding]; other site 1399115005565 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1399115005566 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1399115005567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115005568 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1399115005569 active site 1399115005570 multimer interface [polypeptide binding]; other site 1399115005571 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1399115005572 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1399115005573 substrate binding pocket [chemical binding]; other site 1399115005574 chain length determination region; other site 1399115005575 substrate-Mg2+ binding site; other site 1399115005576 catalytic residues [active] 1399115005577 aspartate-rich region 1; other site 1399115005578 active site lid residues [active] 1399115005579 aspartate-rich region 2; other site 1399115005580 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1399115005581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115005582 S-adenosylmethionine binding site [chemical binding]; other site 1399115005583 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1399115005584 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1399115005585 IHF dimer interface [polypeptide binding]; other site 1399115005586 IHF - DNA interface [nucleotide binding]; other site 1399115005587 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1399115005588 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1399115005589 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1399115005590 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1399115005591 GTP-binding protein Der; Reviewed; Region: PRK00093 1399115005592 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1399115005593 G1 box; other site 1399115005594 GTP/Mg2+ binding site [chemical binding]; other site 1399115005595 Switch I region; other site 1399115005596 G2 box; other site 1399115005597 Switch II region; other site 1399115005598 G3 box; other site 1399115005599 G4 box; other site 1399115005600 G5 box; other site 1399115005601 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1399115005602 G1 box; other site 1399115005603 GTP/Mg2+ binding site [chemical binding]; other site 1399115005604 Switch I region; other site 1399115005605 G2 box; other site 1399115005606 G3 box; other site 1399115005607 Switch II region; other site 1399115005608 G4 box; other site 1399115005609 G5 box; other site 1399115005610 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1399115005611 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1399115005612 RNA binding site [nucleotide binding]; other site 1399115005613 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1399115005614 RNA binding site [nucleotide binding]; other site 1399115005615 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1399115005616 RNA binding site [nucleotide binding]; other site 1399115005617 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1399115005618 RNA binding site [nucleotide binding]; other site 1399115005619 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1399115005620 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1399115005621 putative acyl-acceptor binding pocket; other site 1399115005622 cytidylate kinase; Provisional; Region: cmk; PRK00023 1399115005623 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1399115005624 CMP-binding site; other site 1399115005625 The sites determining sugar specificity; other site 1399115005626 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1399115005627 PilZ domain; Region: PilZ; pfam07238 1399115005628 Protease prsW family; Region: PrsW-protease; pfam13367 1399115005629 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1399115005630 active site 1399115005631 homotetramer interface [polypeptide binding]; other site 1399115005632 homodimer interface [polypeptide binding]; other site 1399115005633 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1399115005634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1399115005635 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115005636 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1399115005637 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1399115005638 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1399115005639 NAD(P) binding site [chemical binding]; other site 1399115005640 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1399115005641 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1399115005642 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115005643 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1399115005644 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1399115005645 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1399115005646 DNA binding residues [nucleotide binding] 1399115005647 B12 binding domain; Region: B12-binding_2; pfam02607 1399115005648 B12 binding domain; Region: B12-binding; pfam02310 1399115005649 B12 binding site [chemical binding]; other site 1399115005650 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1399115005651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115005652 ATP binding site [chemical binding]; other site 1399115005653 putative Mg++ binding site [ion binding]; other site 1399115005654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115005655 nucleotide binding region [chemical binding]; other site 1399115005656 ATP-binding site [chemical binding]; other site 1399115005657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1399115005658 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1399115005659 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1399115005660 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1399115005661 TM-ABC transporter signature motif; other site 1399115005662 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1399115005663 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1399115005664 TM-ABC transporter signature motif; other site 1399115005665 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1399115005666 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1399115005667 Walker A/P-loop; other site 1399115005668 ATP binding site [chemical binding]; other site 1399115005669 Q-loop/lid; other site 1399115005670 ABC transporter signature motif; other site 1399115005671 Walker B; other site 1399115005672 D-loop; other site 1399115005673 H-loop/switch region; other site 1399115005674 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1399115005675 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1399115005676 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1399115005677 ligand binding site [chemical binding]; other site 1399115005678 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1399115005679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115005680 DNA-binding site [nucleotide binding]; DNA binding site 1399115005681 UTRA domain; Region: UTRA; pfam07702 1399115005682 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1399115005683 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1399115005684 ligand binding site [chemical binding]; other site 1399115005685 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1399115005686 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1399115005687 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1399115005688 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1399115005689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115005690 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1399115005691 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1399115005692 FemAB family; Region: FemAB; pfam02388 1399115005693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1399115005694 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1399115005695 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1399115005696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1399115005697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1399115005698 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1399115005699 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1399115005700 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1399115005701 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1399115005702 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1399115005703 RNase E interface [polypeptide binding]; other site 1399115005704 trimer interface [polypeptide binding]; other site 1399115005705 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1399115005706 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1399115005707 RNase E interface [polypeptide binding]; other site 1399115005708 trimer interface [polypeptide binding]; other site 1399115005709 active site 1399115005710 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1399115005711 putative nucleic acid binding region [nucleotide binding]; other site 1399115005712 G-X-X-G motif; other site 1399115005713 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1399115005714 RNA binding site [nucleotide binding]; other site 1399115005715 domain interface; other site 1399115005716 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1399115005717 16S/18S rRNA binding site [nucleotide binding]; other site 1399115005718 S13e-L30e interaction site [polypeptide binding]; other site 1399115005719 25S rRNA binding site [nucleotide binding]; other site 1399115005720 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1399115005721 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1399115005722 active site 1399115005723 Riboflavin kinase; Region: Flavokinase; smart00904 1399115005724 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1399115005725 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1399115005726 RNA binding site [nucleotide binding]; other site 1399115005727 active site 1399115005728 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1399115005729 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1399115005730 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1399115005731 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1399115005732 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1399115005733 G1 box; other site 1399115005734 putative GEF interaction site [polypeptide binding]; other site 1399115005735 GTP/Mg2+ binding site [chemical binding]; other site 1399115005736 Switch I region; other site 1399115005737 G2 box; other site 1399115005738 G3 box; other site 1399115005739 Switch II region; other site 1399115005740 G4 box; other site 1399115005741 G5 box; other site 1399115005742 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1399115005743 Translation-initiation factor 2; Region: IF-2; pfam11987 1399115005744 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1399115005745 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1399115005746 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1399115005747 putative RNA binding cleft [nucleotide binding]; other site 1399115005748 NusA N-terminal domain; Region: NusA_N; pfam08529 1399115005749 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1399115005750 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1399115005751 RNA binding site [nucleotide binding]; other site 1399115005752 homodimer interface [polypeptide binding]; other site 1399115005753 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1399115005754 G-X-X-G motif; other site 1399115005755 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1399115005756 G-X-X-G motif; other site 1399115005757 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1399115005758 Sm and related proteins; Region: Sm_like; cl00259 1399115005759 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1399115005760 putative oligomer interface [polypeptide binding]; other site 1399115005761 putative RNA binding site [nucleotide binding]; other site 1399115005762 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1399115005763 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1399115005764 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1399115005765 generic binding surface II; other site 1399115005766 generic binding surface I; other site 1399115005767 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1399115005768 active site 1399115005769 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1399115005770 active site 1399115005771 catalytic site [active] 1399115005772 substrate binding site [chemical binding]; other site 1399115005773 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1399115005774 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1399115005775 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1399115005776 dimer interface [polypeptide binding]; other site 1399115005777 motif 1; other site 1399115005778 active site 1399115005779 motif 2; other site 1399115005780 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1399115005781 putative deacylase active site [active] 1399115005782 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1399115005783 active site 1399115005784 motif 3; other site 1399115005785 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1399115005786 anticodon binding site; other site 1399115005787 RIP metalloprotease RseP; Region: TIGR00054 1399115005788 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1399115005789 active site 1399115005790 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1399115005791 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1399115005792 protein binding site [polypeptide binding]; other site 1399115005793 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1399115005794 putative substrate binding region [chemical binding]; other site 1399115005795 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1399115005796 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1399115005797 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1399115005798 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1399115005799 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1399115005800 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1399115005801 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1399115005802 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1399115005803 catalytic residue [active] 1399115005804 putative FPP diphosphate binding site; other site 1399115005805 putative FPP binding hydrophobic cleft; other site 1399115005806 dimer interface [polypeptide binding]; other site 1399115005807 putative IPP diphosphate binding site; other site 1399115005808 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1399115005809 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1399115005810 hinge region; other site 1399115005811 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1399115005812 putative nucleotide binding site [chemical binding]; other site 1399115005813 uridine monophosphate binding site [chemical binding]; other site 1399115005814 homohexameric interface [polypeptide binding]; other site 1399115005815 elongation factor Ts; Provisional; Region: tsf; PRK09377 1399115005816 UBA/TS-N domain; Region: UBA; pfam00627 1399115005817 Elongation factor TS; Region: EF_TS; pfam00889 1399115005818 Elongation factor TS; Region: EF_TS; pfam00889 1399115005819 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1399115005820 rRNA interaction site [nucleotide binding]; other site 1399115005821 S8 interaction site; other site 1399115005822 putative laminin-1 binding site; other site 1399115005823 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1399115005824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115005825 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1399115005826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115005827 DNA binding residues [nucleotide binding] 1399115005828 CheD chemotactic sensory transduction; Region: CheD; cl00810 1399115005829 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1399115005830 CheC-like family; Region: CheC; pfam04509 1399115005831 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1399115005832 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1399115005833 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1399115005834 putative binding surface; other site 1399115005835 active site 1399115005836 P2 response regulator binding domain; Region: P2; pfam07194 1399115005837 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1399115005838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115005839 ATP binding site [chemical binding]; other site 1399115005840 Mg2+ binding site [ion binding]; other site 1399115005841 G-X-G motif; other site 1399115005842 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1399115005843 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1399115005844 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1399115005845 P-loop; other site 1399115005846 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1399115005847 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1399115005848 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1399115005849 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1399115005850 FHIPEP family; Region: FHIPEP; pfam00771 1399115005851 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1399115005852 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1399115005853 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1399115005854 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1399115005855 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1399115005856 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1399115005857 Response regulator receiver domain; Region: Response_reg; pfam00072 1399115005858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115005859 active site 1399115005860 phosphorylation site [posttranslational modification] 1399115005861 intermolecular recognition site; other site 1399115005862 dimerization interface [polypeptide binding]; other site 1399115005863 flagellar motor switch protein; Validated; Region: PRK08119 1399115005864 CheC-like family; Region: CheC; pfam04509 1399115005865 CheC-like family; Region: CheC; pfam04509 1399115005866 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1399115005867 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1399115005868 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1399115005869 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1399115005870 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1399115005871 Flagellar protein (FlbD); Region: FlbD; pfam06289 1399115005872 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1399115005873 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1399115005874 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1399115005875 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1399115005876 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1399115005877 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1399115005878 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1399115005879 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1399115005880 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1399115005881 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1399115005882 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1399115005883 Walker A motif/ATP binding site; other site 1399115005884 Walker B motif; other site 1399115005885 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1399115005886 Flagellar assembly protein FliH; Region: FliH; pfam02108 1399115005887 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1399115005888 FliG C-terminal domain; Region: FliG_C; pfam01706 1399115005889 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1399115005890 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1399115005891 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1399115005892 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1399115005893 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1399115005894 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1399115005895 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1399115005896 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1399115005897 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1399115005898 transcriptional repressor CodY; Validated; Region: PRK04158 1399115005899 CodY GAF-like domain; Region: CodY; pfam06018 1399115005900 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1399115005901 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1399115005902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115005903 Walker A motif; other site 1399115005904 ATP binding site [chemical binding]; other site 1399115005905 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1399115005906 Walker B motif; other site 1399115005907 arginine finger; other site 1399115005908 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1399115005909 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1399115005910 active site 1399115005911 HslU subunit interaction site [polypeptide binding]; other site 1399115005912 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1399115005913 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1399115005914 active site 1399115005915 DNA binding site [nucleotide binding] 1399115005916 Int/Topo IB signature motif; other site 1399115005917 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1399115005918 Glucose inhibited division protein A; Region: GIDA; pfam01134 1399115005919 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1399115005920 DNA protecting protein DprA; Region: dprA; TIGR00732 1399115005921 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1399115005922 CoA binding domain; Region: CoA_binding; pfam02629 1399115005923 CoA-ligase; Region: Ligase_CoA; pfam00549 1399115005924 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1399115005925 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1399115005926 CoA-ligase; Region: Ligase_CoA; pfam00549 1399115005927 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1399115005928 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1399115005929 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1399115005930 RNA/DNA hybrid binding site [nucleotide binding]; other site 1399115005931 active site 1399115005932 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1399115005933 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1399115005934 GTP/Mg2+ binding site [chemical binding]; other site 1399115005935 G4 box; other site 1399115005936 G5 box; other site 1399115005937 G1 box; other site 1399115005938 Switch I region; other site 1399115005939 G2 box; other site 1399115005940 G3 box; other site 1399115005941 Switch II region; other site 1399115005942 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1399115005943 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1399115005944 Catalytic site [active] 1399115005945 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1399115005946 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1399115005947 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1399115005948 RimM N-terminal domain; Region: RimM; pfam01782 1399115005949 PRC-barrel domain; Region: PRC; pfam05239 1399115005950 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1399115005951 signal recognition particle protein; Provisional; Region: PRK10867 1399115005952 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1399115005953 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1399115005954 P loop; other site 1399115005955 GTP binding site [chemical binding]; other site 1399115005956 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1399115005957 putative DNA-binding protein; Validated; Region: PRK00118 1399115005958 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1399115005959 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1399115005960 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1399115005961 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1399115005962 P loop; other site 1399115005963 GTP binding site [chemical binding]; other site 1399115005964 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1399115005965 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1399115005966 Walker A/P-loop; other site 1399115005967 ATP binding site [chemical binding]; other site 1399115005968 Q-loop/lid; other site 1399115005969 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1399115005970 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1399115005971 ABC transporter signature motif; other site 1399115005972 Walker B; other site 1399115005973 D-loop; other site 1399115005974 H-loop/switch region; other site 1399115005975 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1399115005976 ribonuclease III; Reviewed; Region: rnc; PRK00102 1399115005977 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1399115005978 dimerization interface [polypeptide binding]; other site 1399115005979 active site 1399115005980 metal binding site [ion binding]; metal-binding site 1399115005981 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1399115005982 dsRNA binding site [nucleotide binding]; other site 1399115005983 acyl carrier protein; Provisional; Region: acpP; PRK00982 1399115005984 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1399115005985 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1399115005986 NAD(P) binding site [chemical binding]; other site 1399115005987 homotetramer interface [polypeptide binding]; other site 1399115005988 homodimer interface [polypeptide binding]; other site 1399115005989 active site 1399115005990 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1399115005991 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1399115005992 putative phosphate acyltransferase; Provisional; Region: PRK05331 1399115005993 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1399115005994 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1399115005995 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1399115005996 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1399115005997 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1399115005998 ssDNA binding site; other site 1399115005999 generic binding surface II; other site 1399115006000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115006001 ATP binding site [chemical binding]; other site 1399115006002 putative Mg++ binding site [ion binding]; other site 1399115006003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115006004 nucleotide binding region [chemical binding]; other site 1399115006005 ATP-binding site [chemical binding]; other site 1399115006006 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1399115006007 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1399115006008 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1399115006009 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1399115006010 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1399115006011 putative L-serine binding site [chemical binding]; other site 1399115006012 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1399115006013 DAK2 domain; Region: Dak2; pfam02734 1399115006014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1399115006015 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1399115006016 S-methylmethionine transporter; Provisional; Region: PRK11387 1399115006017 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1399115006018 Thiamine pyrophosphokinase; Region: TPK; cd07995 1399115006019 active site 1399115006020 dimerization interface [polypeptide binding]; other site 1399115006021 thiamine binding site [chemical binding]; other site 1399115006022 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1399115006023 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1399115006024 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1399115006025 substrate binding site [chemical binding]; other site 1399115006026 hexamer interface [polypeptide binding]; other site 1399115006027 metal binding site [ion binding]; metal-binding site 1399115006028 GTPase RsgA; Reviewed; Region: PRK00098 1399115006029 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1399115006030 RNA binding site [nucleotide binding]; other site 1399115006031 homodimer interface [polypeptide binding]; other site 1399115006032 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1399115006033 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1399115006034 GTP/Mg2+ binding site [chemical binding]; other site 1399115006035 G4 box; other site 1399115006036 G5 box; other site 1399115006037 G1 box; other site 1399115006038 Switch I region; other site 1399115006039 G2 box; other site 1399115006040 G3 box; other site 1399115006041 Switch II region; other site 1399115006042 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1399115006043 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1399115006044 active site 1399115006045 ATP binding site [chemical binding]; other site 1399115006046 substrate binding site [chemical binding]; other site 1399115006047 activation loop (A-loop); other site 1399115006048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1399115006049 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1399115006050 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1399115006051 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1399115006052 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1399115006053 Protein phosphatase 2C; Region: PP2C; pfam00481 1399115006054 active site 1399115006055 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1399115006056 NusB family; Region: NusB; pfam01029 1399115006057 putative RNA binding site [nucleotide binding]; other site 1399115006058 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1399115006059 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1399115006060 active site 1399115006061 catalytic residues [active] 1399115006062 metal binding site [ion binding]; metal-binding site 1399115006063 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1399115006064 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1399115006065 putative active site [active] 1399115006066 substrate binding site [chemical binding]; other site 1399115006067 putative cosubstrate binding site; other site 1399115006068 catalytic site [active] 1399115006069 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1399115006070 substrate binding site [chemical binding]; other site 1399115006071 primosome assembly protein PriA; Validated; Region: PRK05580 1399115006072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115006073 ATP binding site [chemical binding]; other site 1399115006074 putative Mg++ binding site [ion binding]; other site 1399115006075 nucleotide binding region [chemical binding]; other site 1399115006076 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1399115006077 ATP-binding site [chemical binding]; other site 1399115006078 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1399115006079 Flavoprotein; Region: Flavoprotein; pfam02441 1399115006080 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1399115006081 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1399115006082 Guanylate kinase; Region: Guanylate_kin; pfam00625 1399115006083 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1399115006084 catalytic site [active] 1399115006085 G-X2-G-X-G-K; other site 1399115006086 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1399115006087 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1399115006088 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1399115006089 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1399115006090 metal-dependent hydrolase; Provisional; Region: PRK00685 1399115006091 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115006092 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115006093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115006094 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1399115006095 active site 1399115006096 metal binding site [ion binding]; metal-binding site 1399115006097 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1399115006098 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115006099 putative NAD(P) binding site [chemical binding]; other site 1399115006100 substrate binding site [chemical binding]; other site 1399115006101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1399115006102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115006103 active site 1399115006104 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1399115006105 active site 1399115006106 dimer interface [polypeptide binding]; other site 1399115006107 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1399115006108 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1399115006109 heterodimer interface [polypeptide binding]; other site 1399115006110 active site 1399115006111 FMN binding site [chemical binding]; other site 1399115006112 homodimer interface [polypeptide binding]; other site 1399115006113 substrate binding site [chemical binding]; other site 1399115006114 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1399115006115 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1399115006116 FAD binding pocket [chemical binding]; other site 1399115006117 FAD binding motif [chemical binding]; other site 1399115006118 phosphate binding motif [ion binding]; other site 1399115006119 beta-alpha-beta structure motif; other site 1399115006120 NAD binding pocket [chemical binding]; other site 1399115006121 Iron coordination center [ion binding]; other site 1399115006122 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1399115006123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1399115006124 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1399115006125 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1399115006126 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1399115006127 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115006128 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1399115006129 IMP binding site; other site 1399115006130 dimer interface [polypeptide binding]; other site 1399115006131 interdomain contacts; other site 1399115006132 partial ornithine binding site; other site 1399115006133 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1399115006134 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1399115006135 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1399115006136 catalytic site [active] 1399115006137 subunit interface [polypeptide binding]; other site 1399115006138 dihydroorotase; Validated; Region: pyrC; PRK09357 1399115006139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1399115006140 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1399115006141 active site 1399115006142 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1399115006143 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1399115006144 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1399115006145 uracil-xanthine permease; Region: ncs2; TIGR00801 1399115006146 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1399115006147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115006148 active site 1399115006149 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1399115006150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115006151 RNA binding surface [nucleotide binding]; other site 1399115006152 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1399115006153 active site 1399115006154 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1399115006155 lipoprotein signal peptidase; Provisional; Region: PRK14787 1399115006156 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1399115006157 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1399115006158 active site 1399115006159 HIGH motif; other site 1399115006160 nucleotide binding site [chemical binding]; other site 1399115006161 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1399115006162 active site 1399115006163 KMSKS motif; other site 1399115006164 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1399115006165 tRNA binding surface [nucleotide binding]; other site 1399115006166 anticodon binding site; other site 1399115006167 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1399115006168 DivIVA protein; Region: DivIVA; pfam05103 1399115006169 DivIVA domain; Region: DivI1A_domain; TIGR03544 1399115006170 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1399115006171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115006172 RNA binding surface [nucleotide binding]; other site 1399115006173 YGGT family; Region: YGGT; pfam02325 1399115006174 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1399115006175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1399115006176 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1399115006177 catalytic residue [active] 1399115006178 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1399115006179 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1399115006180 cell division protein FtsZ; Validated; Region: PRK09330 1399115006181 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1399115006182 nucleotide binding site [chemical binding]; other site 1399115006183 SulA interaction site; other site 1399115006184 cell division protein FtsA; Region: ftsA; TIGR01174 1399115006185 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1399115006186 nucleotide binding site [chemical binding]; other site 1399115006187 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1399115006188 Cell division protein FtsA; Region: FtsA; pfam14450 1399115006189 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1399115006190 Cell division protein FtsQ; Region: FtsQ; pfam03799 1399115006191 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1399115006192 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1399115006193 active site 1399115006194 homodimer interface [polypeptide binding]; other site 1399115006195 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1399115006196 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1399115006197 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1399115006198 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1399115006199 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1399115006200 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1399115006201 Mg++ binding site [ion binding]; other site 1399115006202 putative catalytic motif [active] 1399115006203 putative substrate binding site [chemical binding]; other site 1399115006204 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1399115006205 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1399115006206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1399115006207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1399115006208 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1399115006209 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1399115006210 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1399115006211 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1399115006212 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1399115006213 Cell division protein FtsL; Region: FtsL; cl11433 1399115006214 MraW methylase family; Region: Methyltransf_5; pfam01795 1399115006215 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1399115006216 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1399115006217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1399115006218 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1399115006219 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1399115006220 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1399115006221 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1399115006222 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1399115006223 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1399115006224 hypothetical protein; Provisional; Region: PRK13670 1399115006225 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1399115006226 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1399115006227 protein binding site [polypeptide binding]; other site 1399115006228 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1399115006229 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1399115006230 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1399115006231 active site 1399115006232 (T/H)XGH motif; other site 1399115006233 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1399115006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115006235 S-adenosylmethionine binding site [chemical binding]; other site 1399115006236 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1399115006237 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1399115006238 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115006239 YugN-like family; Region: YugN; pfam08868 1399115006240 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1399115006241 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1399115006242 Cu(I) binding site [ion binding]; other site 1399115006243 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1399115006244 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1399115006245 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1399115006246 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1399115006247 Subunit I/III interface [polypeptide binding]; other site 1399115006248 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1399115006249 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1399115006250 D-pathway; other site 1399115006251 Putative ubiquinol binding site [chemical binding]; other site 1399115006252 Low-spin heme (heme b) binding site [chemical binding]; other site 1399115006253 Putative water exit pathway; other site 1399115006254 Binuclear center (heme o3/CuB) [ion binding]; other site 1399115006255 K-pathway; other site 1399115006256 Putative proton exit pathway; other site 1399115006257 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1399115006258 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1399115006259 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1399115006260 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1399115006261 UbiA prenyltransferase family; Region: UbiA; pfam01040 1399115006262 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1399115006263 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1399115006264 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1399115006265 DNA photolyase; Region: DNA_photolyase; pfam00875 1399115006266 pyruvate carboxylase; Reviewed; Region: PRK12999 1399115006267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1399115006268 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1399115006269 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1399115006270 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1399115006271 active site 1399115006272 catalytic residues [active] 1399115006273 metal binding site [ion binding]; metal-binding site 1399115006274 homodimer binding site [polypeptide binding]; other site 1399115006275 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1399115006276 carboxyltransferase (CT) interaction site; other site 1399115006277 biotinylation site [posttranslational modification]; other site 1399115006278 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1399115006279 hypothetical protein; Provisional; Region: PRK13666 1399115006280 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1399115006281 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1399115006282 putative active site [active] 1399115006283 PhoH-like protein; Region: PhoH; pfam02562 1399115006284 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1399115006285 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1399115006286 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1399115006287 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1399115006288 YlaH-like protein; Region: YlaH; pfam14036 1399115006289 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1399115006290 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1399115006291 G1 box; other site 1399115006292 putative GEF interaction site [polypeptide binding]; other site 1399115006293 GTP/Mg2+ binding site [chemical binding]; other site 1399115006294 Switch I region; other site 1399115006295 G2 box; other site 1399115006296 G3 box; other site 1399115006297 Switch II region; other site 1399115006298 G4 box; other site 1399115006299 G5 box; other site 1399115006300 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1399115006301 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1399115006302 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1399115006303 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1399115006304 active site 1399115006305 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1399115006306 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1399115006307 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1399115006308 homodimer interface [polypeptide binding]; other site 1399115006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115006310 catalytic residue [active] 1399115006311 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1399115006312 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1399115006313 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1399115006314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115006315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115006316 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115006317 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1399115006318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1399115006319 E3 interaction surface; other site 1399115006320 lipoyl attachment site [posttranslational modification]; other site 1399115006321 e3 binding domain; Region: E3_binding; pfam02817 1399115006322 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1399115006323 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1399115006324 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1399115006325 alpha subunit interface [polypeptide binding]; other site 1399115006326 TPP binding site [chemical binding]; other site 1399115006327 heterodimer interface [polypeptide binding]; other site 1399115006328 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1399115006329 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1399115006330 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1399115006331 TPP-binding site [chemical binding]; other site 1399115006332 tetramer interface [polypeptide binding]; other site 1399115006333 heterodimer interface [polypeptide binding]; other site 1399115006334 phosphorylation loop region [posttranslational modification] 1399115006335 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1399115006336 active site 1399115006337 catalytic residues [active] 1399115006338 metal binding site [ion binding]; metal-binding site 1399115006339 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1399115006340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1399115006341 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1399115006342 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1399115006343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115006344 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1399115006345 active site 1399115006346 motif I; other site 1399115006347 motif II; other site 1399115006348 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1399115006349 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1399115006350 TrkA-N domain; Region: TrkA_N; pfam02254 1399115006351 TrkA-C domain; Region: TrkA_C; pfam02080 1399115006352 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1399115006353 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1399115006354 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1399115006355 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1399115006356 metal binding site [ion binding]; metal-binding site 1399115006357 putative dimer interface [polypeptide binding]; other site 1399115006358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115006359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115006360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1399115006361 dimerization interface [polypeptide binding]; other site 1399115006362 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1399115006363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115006364 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1399115006365 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1399115006366 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1399115006367 homodimer interface [polypeptide binding]; other site 1399115006368 NAD binding pocket [chemical binding]; other site 1399115006369 ATP binding pocket [chemical binding]; other site 1399115006370 Mg binding site [ion binding]; other site 1399115006371 active-site loop [active] 1399115006372 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1399115006373 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1399115006374 Virulence factor; Region: Virulence_fact; pfam13769 1399115006375 HEAT repeats; Region: HEAT_2; pfam13646 1399115006376 HEAT repeats; Region: HEAT_2; pfam13646 1399115006377 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1399115006378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1399115006379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115006380 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1399115006381 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1399115006382 EDD domain protein, DegV family; Region: DegV; TIGR00762 1399115006383 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1399115006384 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1399115006385 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1399115006386 active site 1399115006387 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1399115006388 tetramer interfaces [polypeptide binding]; other site 1399115006389 binuclear metal-binding site [ion binding]; other site 1399115006390 hypothetical protein; Provisional; Region: PRK13679 1399115006391 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1399115006392 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1399115006393 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1399115006394 NAD binding site [chemical binding]; other site 1399115006395 homotetramer interface [polypeptide binding]; other site 1399115006396 homodimer interface [polypeptide binding]; other site 1399115006397 substrate binding site [chemical binding]; other site 1399115006398 active site 1399115006399 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1399115006400 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1399115006401 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1399115006402 active site 1399115006403 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1399115006404 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1399115006405 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1399115006406 synthetase active site [active] 1399115006407 NTP binding site [chemical binding]; other site 1399115006408 metal binding site [ion binding]; metal-binding site 1399115006409 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1399115006410 putative active site [active] 1399115006411 putative metal binding residues [ion binding]; other site 1399115006412 signature motif; other site 1399115006413 putative triphosphate binding site [ion binding]; other site 1399115006414 Thioredoxin; Region: Thioredoxin_5; pfam13743 1399115006415 oligoendopeptidase F; Region: pepF; TIGR00181 1399115006416 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1399115006417 active site 1399115006418 Zn binding site [ion binding]; other site 1399115006419 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1399115006420 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1399115006421 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1399115006422 putative active site [active] 1399115006423 catalytic site [active] 1399115006424 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1399115006425 putative active site [active] 1399115006426 catalytic site [active] 1399115006427 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1399115006428 classical (c) SDRs; Region: SDR_c; cd05233 1399115006429 NAD(P) binding site [chemical binding]; other site 1399115006430 active site 1399115006431 adaptor protein; Provisional; Region: PRK02315 1399115006432 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1399115006433 ArsC family; Region: ArsC; pfam03960 1399115006434 putative catalytic residues [active] 1399115006435 thiol/disulfide switch; other site 1399115006436 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1399115006437 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1399115006438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1399115006439 Walker A/P-loop; other site 1399115006440 ATP binding site [chemical binding]; other site 1399115006441 Q-loop/lid; other site 1399115006442 ABC transporter signature motif; other site 1399115006443 Walker B; other site 1399115006444 D-loop; other site 1399115006445 H-loop/switch region; other site 1399115006446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1399115006447 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1399115006448 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1399115006449 Walker A/P-loop; other site 1399115006450 ATP binding site [chemical binding]; other site 1399115006451 Q-loop/lid; other site 1399115006452 ABC transporter signature motif; other site 1399115006453 Walker B; other site 1399115006454 D-loop; other site 1399115006455 H-loop/switch region; other site 1399115006456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1399115006457 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1399115006458 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1399115006459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115006460 dimer interface [polypeptide binding]; other site 1399115006461 conserved gate region; other site 1399115006462 putative PBP binding loops; other site 1399115006463 ABC-ATPase subunit interface; other site 1399115006464 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1399115006465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115006466 dimer interface [polypeptide binding]; other site 1399115006467 conserved gate region; other site 1399115006468 putative PBP binding loops; other site 1399115006469 ABC-ATPase subunit interface; other site 1399115006470 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1399115006471 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1399115006472 peptide binding site [polypeptide binding]; other site 1399115006473 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1399115006474 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1399115006475 active site 1399115006476 HIGH motif; other site 1399115006477 dimer interface [polypeptide binding]; other site 1399115006478 KMSKS motif; other site 1399115006479 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1399115006480 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1399115006481 peptide binding site [polypeptide binding]; other site 1399115006482 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1399115006483 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1399115006484 peptide binding site [polypeptide binding]; other site 1399115006485 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1399115006486 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1399115006487 dimer interface [polypeptide binding]; other site 1399115006488 active site 1399115006489 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1399115006490 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1399115006491 dimer interface [polypeptide binding]; other site 1399115006492 active site 1399115006493 CoA binding pocket [chemical binding]; other site 1399115006494 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1399115006495 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1399115006496 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1399115006497 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1399115006498 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1399115006499 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1399115006500 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1399115006501 ATP-binding site [chemical binding]; other site 1399115006502 Sugar specificity; other site 1399115006503 Pyrimidine base specificity; other site 1399115006504 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1399115006505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115006506 S-adenosylmethionine binding site [chemical binding]; other site 1399115006507 YceG-like family; Region: YceG; pfam02618 1399115006508 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1399115006509 dimerization interface [polypeptide binding]; other site 1399115006510 hypothetical protein; Provisional; Region: PRK13678 1399115006511 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1399115006512 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1399115006513 hypothetical protein; Provisional; Region: PRK05473 1399115006514 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1399115006515 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1399115006516 motif 1; other site 1399115006517 active site 1399115006518 motif 2; other site 1399115006519 motif 3; other site 1399115006520 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1399115006521 DHHA1 domain; Region: DHHA1; pfam02272 1399115006522 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1399115006523 AAA domain; Region: AAA_30; pfam13604 1399115006524 Family description; Region: UvrD_C_2; pfam13538 1399115006525 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1399115006526 active site 1399115006527 metal binding site [ion binding]; metal-binding site 1399115006528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115006529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1399115006530 binding surface 1399115006531 TPR repeat; Region: TPR_11; pfam13414 1399115006532 TPR motif; other site 1399115006533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1399115006534 binding surface 1399115006535 TPR motif; other site 1399115006536 TPR repeat; Region: TPR_11; pfam13414 1399115006537 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1399115006538 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1399115006539 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1399115006540 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1399115006541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115006542 catalytic residue [active] 1399115006543 Predicted transcriptional regulator [Transcription]; Region: COG1959 1399115006544 Transcriptional regulator; Region: Rrf2; pfam02082 1399115006545 recombination factor protein RarA; Reviewed; Region: PRK13342 1399115006546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115006547 Walker A motif; other site 1399115006548 ATP binding site [chemical binding]; other site 1399115006549 Walker B motif; other site 1399115006550 arginine finger; other site 1399115006551 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1399115006552 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1399115006553 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1399115006554 putative ATP binding site [chemical binding]; other site 1399115006555 putative substrate interface [chemical binding]; other site 1399115006556 DNA photolyase; Region: DNA_photolyase; pfam00875 1399115006557 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 1399115006558 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1399115006559 active site 1399115006560 DNA binding site [nucleotide binding] 1399115006561 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1399115006562 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1399115006563 dimer interface [polypeptide binding]; other site 1399115006564 anticodon binding site; other site 1399115006565 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1399115006566 homodimer interface [polypeptide binding]; other site 1399115006567 motif 1; other site 1399115006568 active site 1399115006569 motif 2; other site 1399115006570 GAD domain; Region: GAD; pfam02938 1399115006571 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1399115006572 motif 3; other site 1399115006573 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1399115006574 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1399115006575 dimer interface [polypeptide binding]; other site 1399115006576 motif 1; other site 1399115006577 active site 1399115006578 motif 2; other site 1399115006579 motif 3; other site 1399115006580 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1399115006581 anticodon binding site; other site 1399115006582 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115006583 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1399115006584 putative active site [active] 1399115006585 dimerization interface [polypeptide binding]; other site 1399115006586 putative tRNAtyr binding site [nucleotide binding]; other site 1399115006587 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1399115006588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115006589 Zn2+ binding site [ion binding]; other site 1399115006590 Mg2+ binding site [ion binding]; other site 1399115006591 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1399115006592 synthetase active site [active] 1399115006593 NTP binding site [chemical binding]; other site 1399115006594 metal binding site [ion binding]; metal-binding site 1399115006595 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1399115006596 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1399115006597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115006598 active site 1399115006599 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1399115006600 DHH family; Region: DHH; pfam01368 1399115006601 DHHA1 domain; Region: DHHA1; pfam02272 1399115006602 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1399115006603 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1399115006604 Protein export membrane protein; Region: SecD_SecF; pfam02355 1399115006605 protein-export membrane protein SecD; Region: secD; TIGR01129 1399115006606 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1399115006607 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1399115006608 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1399115006609 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1399115006610 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1399115006611 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1399115006612 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1399115006613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115006614 Walker A motif; other site 1399115006615 ATP binding site [chemical binding]; other site 1399115006616 Walker B motif; other site 1399115006617 arginine finger; other site 1399115006618 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1399115006619 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1399115006620 RuvA N terminal domain; Region: RuvA_N; pfam01330 1399115006621 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1399115006622 DNA binding site [nucleotide binding] 1399115006623 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1399115006624 quinolinate synthetase; Provisional; Region: PRK09375 1399115006625 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1399115006626 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1399115006627 dimerization interface [polypeptide binding]; other site 1399115006628 active site 1399115006629 L-aspartate oxidase; Provisional; Region: PRK06175 1399115006630 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1399115006631 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1399115006632 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1399115006633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115006634 catalytic residue [active] 1399115006635 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1399115006636 HTH domain; Region: HTH_11; pfam08279 1399115006637 3H domain; Region: 3H; pfam02829 1399115006638 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1399115006639 Domain of unknown function DUF21; Region: DUF21; pfam01595 1399115006640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1399115006641 Transporter associated domain; Region: CorC_HlyC; pfam03471 1399115006642 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1399115006643 GTP1/OBG; Region: GTP1_OBG; pfam01018 1399115006644 Obg GTPase; Region: Obg; cd01898 1399115006645 G1 box; other site 1399115006646 GTP/Mg2+ binding site [chemical binding]; other site 1399115006647 Switch I region; other site 1399115006648 G2 box; other site 1399115006649 G3 box; other site 1399115006650 Switch II region; other site 1399115006651 G4 box; other site 1399115006652 G5 box; other site 1399115006653 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1399115006654 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1399115006655 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1399115006656 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1399115006657 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1399115006658 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1399115006659 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1399115006660 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1399115006661 Switch I; other site 1399115006662 Switch II; other site 1399115006663 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1399115006664 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1399115006665 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1399115006666 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1399115006667 rod shape-determining protein MreC; Region: MreC; pfam04085 1399115006668 rod shape-determining protein MreB; Provisional; Region: PRK13927 1399115006669 MreB and similar proteins; Region: MreB_like; cd10225 1399115006670 nucleotide binding site [chemical binding]; other site 1399115006671 Mg binding site [ion binding]; other site 1399115006672 putative protofilament interaction site [polypeptide binding]; other site 1399115006673 RodZ interaction site [polypeptide binding]; other site 1399115006674 DNA repair protein radc; Region: radc; TIGR00608 1399115006675 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1399115006676 MPN+ (JAMM) motif; other site 1399115006677 Zinc-binding site [ion binding]; other site 1399115006678 Maf-like protein; Region: Maf; pfam02545 1399115006679 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1399115006680 active site 1399115006681 dimer interface [polypeptide binding]; other site 1399115006682 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1399115006683 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1399115006684 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1399115006685 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1399115006686 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1399115006687 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1399115006688 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1399115006689 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1399115006690 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1399115006691 Walker A motif; other site 1399115006692 ATP binding site [chemical binding]; other site 1399115006693 Walker B motif; other site 1399115006694 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1399115006695 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1399115006696 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1399115006697 Walker A motif; other site 1399115006698 ATP binding site [chemical binding]; other site 1399115006699 Walker B motif; other site 1399115006700 VanW like protein; Region: VanW; pfam04294 1399115006701 G5 domain; Region: G5; pfam07501 1399115006702 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1399115006703 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1399115006704 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1399115006705 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1399115006706 active site 1399115006707 HIGH motif; other site 1399115006708 nucleotide binding site [chemical binding]; other site 1399115006709 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1399115006710 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1399115006711 active site 1399115006712 KMSKS motif; other site 1399115006713 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1399115006714 tRNA binding surface [nucleotide binding]; other site 1399115006715 anticodon binding site; other site 1399115006716 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1399115006717 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1399115006718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1399115006719 inhibitor-cofactor binding pocket; inhibition site 1399115006720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115006721 catalytic residue [active] 1399115006722 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1399115006723 dimer interface [polypeptide binding]; other site 1399115006724 active site 1399115006725 Schiff base residues; other site 1399115006726 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1399115006727 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1399115006728 active site 1399115006729 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1399115006730 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1399115006731 domain interfaces; other site 1399115006732 active site 1399115006733 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1399115006734 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1399115006735 tRNA; other site 1399115006736 putative tRNA binding site [nucleotide binding]; other site 1399115006737 putative NADP binding site [chemical binding]; other site 1399115006738 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1399115006739 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1399115006740 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1399115006741 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1399115006742 G1 box; other site 1399115006743 GTP/Mg2+ binding site [chemical binding]; other site 1399115006744 Switch I region; other site 1399115006745 G2 box; other site 1399115006746 G3 box; other site 1399115006747 Switch II region; other site 1399115006748 G4 box; other site 1399115006749 G5 box; other site 1399115006750 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1399115006751 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1399115006752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115006753 Walker A motif; other site 1399115006754 ATP binding site [chemical binding]; other site 1399115006755 Walker B motif; other site 1399115006756 arginine finger; other site 1399115006757 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1399115006758 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1399115006759 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1399115006760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115006761 Walker A motif; other site 1399115006762 ATP binding site [chemical binding]; other site 1399115006763 Walker B motif; other site 1399115006764 arginine finger; other site 1399115006765 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1399115006766 trigger factor; Provisional; Region: tig; PRK01490 1399115006767 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1399115006768 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1399115006769 hypothetical protein; Provisional; Region: PRK11281 1399115006770 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1399115006771 active site 1399115006772 metal binding site [ion binding]; metal-binding site 1399115006773 homotetramer interface [polypeptide binding]; other site 1399115006774 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1399115006775 active site 1399115006776 dimerization interface [polypeptide binding]; other site 1399115006777 ribonuclease PH; Reviewed; Region: rph; PRK00173 1399115006778 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1399115006779 hexamer interface [polypeptide binding]; other site 1399115006780 active site 1399115006781 glutamate racemase; Provisional; Region: PRK00865 1399115006782 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1399115006783 dimerization domain swap beta strand [polypeptide binding]; other site 1399115006784 regulatory protein interface [polypeptide binding]; other site 1399115006785 active site 1399115006786 regulatory phosphorylation site [posttranslational modification]; other site 1399115006787 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1399115006788 active site 1399115006789 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1399115006790 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1399115006791 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1399115006792 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1399115006793 L-aspartate oxidase; Provisional; Region: PRK06175 1399115006794 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1399115006795 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1399115006796 putative Iron-sulfur protein interface [polypeptide binding]; other site 1399115006797 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1399115006798 proximal heme binding site [chemical binding]; other site 1399115006799 distal heme binding site [chemical binding]; other site 1399115006800 putative dimer interface [polypeptide binding]; other site 1399115006801 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1399115006802 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1399115006803 pentamer interface [polypeptide binding]; other site 1399115006804 dodecaamer interface [polypeptide binding]; other site 1399115006805 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1399115006806 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1399115006807 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1399115006808 GIY-YIG motif/motif A; other site 1399115006809 active site 1399115006810 catalytic site [active] 1399115006811 putative DNA binding site [nucleotide binding]; other site 1399115006812 metal binding site [ion binding]; metal-binding site 1399115006813 UvrB/uvrC motif; Region: UVR; pfam02151 1399115006814 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1399115006815 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1399115006816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115006817 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115006818 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1399115006819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115006820 active site 1399115006821 metal binding site [ion binding]; metal-binding site 1399115006822 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1399115006823 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1399115006824 catalytic residues [active] 1399115006825 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1399115006826 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1399115006827 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1399115006828 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1399115006829 Ligand binding site [chemical binding]; other site 1399115006830 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1399115006831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115006832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115006833 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1399115006834 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1399115006835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1399115006836 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1399115006837 acyl-activating enzyme (AAE) consensus motif; other site 1399115006838 putative AMP binding site [chemical binding]; other site 1399115006839 putative active site [active] 1399115006840 putative CoA binding site [chemical binding]; other site 1399115006841 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115006842 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115006843 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115006844 Predicted membrane protein [Function unknown]; Region: COG3766 1399115006845 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1399115006846 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1399115006847 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1399115006848 MutS domain III; Region: MutS_III; pfam05192 1399115006849 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1399115006850 Walker A/P-loop; other site 1399115006851 ATP binding site [chemical binding]; other site 1399115006852 Q-loop/lid; other site 1399115006853 ABC transporter signature motif; other site 1399115006854 Walker B; other site 1399115006855 D-loop; other site 1399115006856 H-loop/switch region; other site 1399115006857 Smr domain; Region: Smr; pfam01713 1399115006858 hypothetical protein; Provisional; Region: PRK08609 1399115006859 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1399115006860 active site 1399115006861 primer binding site [nucleotide binding]; other site 1399115006862 NTP binding site [chemical binding]; other site 1399115006863 metal binding triad [ion binding]; metal-binding site 1399115006864 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1399115006865 active site 1399115006866 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1399115006867 Colicin V production protein; Region: Colicin_V; pfam02674 1399115006868 Cell division protein ZapA; Region: ZapA; cl01146 1399115006869 ribonuclease HIII; Provisional; Region: PRK00996 1399115006870 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1399115006871 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1399115006872 RNA/DNA hybrid binding site [nucleotide binding]; other site 1399115006873 active site 1399115006874 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1399115006875 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1399115006876 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1399115006877 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1399115006878 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115006879 MarR family; Region: MarR_2; pfam12802 1399115006880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115006881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115006882 putative substrate translocation pore; other site 1399115006883 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1399115006884 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1399115006885 putative tRNA-binding site [nucleotide binding]; other site 1399115006886 B3/4 domain; Region: B3_4; pfam03483 1399115006887 tRNA synthetase B5 domain; Region: B5; smart00874 1399115006888 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1399115006889 dimer interface [polypeptide binding]; other site 1399115006890 motif 1; other site 1399115006891 motif 3; other site 1399115006892 motif 2; other site 1399115006893 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1399115006894 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1399115006895 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1399115006896 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1399115006897 dimer interface [polypeptide binding]; other site 1399115006898 motif 1; other site 1399115006899 active site 1399115006900 motif 2; other site 1399115006901 motif 3; other site 1399115006902 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115006903 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1399115006904 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1399115006905 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1399115006906 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1399115006907 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1399115006908 oligomer interface [polypeptide binding]; other site 1399115006909 active site 1399115006910 metal binding site [ion binding]; metal-binding site 1399115006911 dUTPase; Region: dUTPase_2; pfam08761 1399115006912 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1399115006913 active site 1399115006914 homodimer interface [polypeptide binding]; other site 1399115006915 metal binding site [ion binding]; metal-binding site 1399115006916 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1399115006917 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1399115006918 23S rRNA binding site [nucleotide binding]; other site 1399115006919 L21 binding site [polypeptide binding]; other site 1399115006920 L13 binding site [polypeptide binding]; other site 1399115006921 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1399115006922 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1399115006923 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1399115006924 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1399115006925 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1399115006926 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1399115006927 tetramer interface [polypeptide binding]; other site 1399115006928 heme binding pocket [chemical binding]; other site 1399115006929 Right handed beta helix region; Region: Beta_helix; pfam13229 1399115006930 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1399115006931 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1399115006932 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1399115006933 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1399115006934 active site 1399115006935 dimer interface [polypeptide binding]; other site 1399115006936 motif 1; other site 1399115006937 motif 2; other site 1399115006938 motif 3; other site 1399115006939 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1399115006940 anticodon binding site; other site 1399115006941 primosomal protein DnaI; Reviewed; Region: PRK08939 1399115006942 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1399115006943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115006944 Walker A motif; other site 1399115006945 ATP binding site [chemical binding]; other site 1399115006946 Walker B motif; other site 1399115006947 arginine finger; other site 1399115006948 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1399115006949 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1399115006950 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1399115006951 ATP cone domain; Region: ATP-cone; pfam03477 1399115006952 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1399115006953 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1399115006954 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1399115006955 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1399115006956 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1399115006957 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1399115006958 CoA-binding site [chemical binding]; other site 1399115006959 ATP-binding [chemical binding]; other site 1399115006960 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1399115006961 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1399115006962 DNA binding site [nucleotide binding] 1399115006963 catalytic residue [active] 1399115006964 H2TH interface [polypeptide binding]; other site 1399115006965 putative catalytic residues [active] 1399115006966 turnover-facilitating residue; other site 1399115006967 intercalation triad [nucleotide binding]; other site 1399115006968 8OG recognition residue [nucleotide binding]; other site 1399115006969 putative reading head residues; other site 1399115006970 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1399115006971 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1399115006972 DNA polymerase I; Provisional; Region: PRK05755 1399115006973 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1399115006974 active site 1399115006975 metal binding site 1 [ion binding]; metal-binding site 1399115006976 putative 5' ssDNA interaction site; other site 1399115006977 metal binding site 3; metal-binding site 1399115006978 metal binding site 2 [ion binding]; metal-binding site 1399115006979 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1399115006980 putative DNA binding site [nucleotide binding]; other site 1399115006981 putative metal binding site [ion binding]; other site 1399115006982 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1399115006983 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1399115006984 active site 1399115006985 DNA binding site [nucleotide binding] 1399115006986 catalytic site [active] 1399115006987 HAMP domain; Region: HAMP; pfam00672 1399115006988 dimerization interface [polypeptide binding]; other site 1399115006989 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1399115006990 PAS domain; Region: PAS; smart00091 1399115006991 putative active site [active] 1399115006992 heme pocket [chemical binding]; other site 1399115006993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115006994 dimer interface [polypeptide binding]; other site 1399115006995 phosphorylation site [posttranslational modification] 1399115006996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115006997 ATP binding site [chemical binding]; other site 1399115006998 G-X-G motif; other site 1399115006999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115007000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115007001 active site 1399115007002 phosphorylation site [posttranslational modification] 1399115007003 intermolecular recognition site; other site 1399115007004 dimerization interface [polypeptide binding]; other site 1399115007005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115007006 DNA binding site [nucleotide binding] 1399115007007 Divergent PAP2 family; Region: DUF212; pfam02681 1399115007008 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1399115007009 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1399115007010 NAD binding site [chemical binding]; other site 1399115007011 catalytic Zn binding site [ion binding]; other site 1399115007012 structural Zn binding site [ion binding]; other site 1399115007013 malate dehydrogenase; Reviewed; Region: PRK06223 1399115007014 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1399115007015 NAD(P) binding site [chemical binding]; other site 1399115007016 dimer interface [polypeptide binding]; other site 1399115007017 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1399115007018 substrate binding site [chemical binding]; other site 1399115007019 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1399115007020 isocitrate dehydrogenase; Validated; Region: PRK07362 1399115007021 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1399115007022 dimer interface [polypeptide binding]; other site 1399115007023 Citrate synthase; Region: Citrate_synt; pfam00285 1399115007024 active site 1399115007025 citrylCoA binding site [chemical binding]; other site 1399115007026 oxalacetate/citrate binding site [chemical binding]; other site 1399115007027 coenzyme A binding site [chemical binding]; other site 1399115007028 catalytic triad [active] 1399115007029 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1399115007030 pyruvate kinase; Provisional; Region: PRK06354 1399115007031 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1399115007032 domain interfaces; other site 1399115007033 active site 1399115007034 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1399115007035 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1399115007036 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1399115007037 active site 1399115007038 ADP/pyrophosphate binding site [chemical binding]; other site 1399115007039 dimerization interface [polypeptide binding]; other site 1399115007040 allosteric effector site; other site 1399115007041 fructose-1,6-bisphosphate binding site; other site 1399115007042 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1399115007043 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1399115007044 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1399115007045 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1399115007046 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1399115007047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115007048 DNA-binding site [nucleotide binding]; DNA binding site 1399115007049 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1399115007050 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1399115007051 active site 1399115007052 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1399115007053 generic binding surface I; other site 1399115007054 generic binding surface II; other site 1399115007055 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1399115007056 DHH family; Region: DHH; pfam01368 1399115007057 DHHA1 domain; Region: DHHA1; pfam02272 1399115007058 YtpI-like protein; Region: YtpI; pfam14007 1399115007059 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1399115007060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115007061 DNA-binding site [nucleotide binding]; DNA binding site 1399115007062 DRTGG domain; Region: DRTGG; pfam07085 1399115007063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1399115007064 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1399115007065 active site 2 [active] 1399115007066 active site 1 [active] 1399115007067 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1399115007068 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1399115007069 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1399115007070 active site 1399115007071 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1399115007072 classical (c) SDRs; Region: SDR_c; cd05233 1399115007073 NAD(P) binding site [chemical binding]; other site 1399115007074 active site 1399115007075 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1399115007076 Ligand Binding Site [chemical binding]; other site 1399115007077 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115007078 3D domain; Region: 3D; cl01439 1399115007079 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1399115007080 propionate/acetate kinase; Provisional; Region: PRK12379 1399115007081 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1399115007082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115007083 S-adenosylmethionine binding site [chemical binding]; other site 1399115007084 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1399115007085 dimer interface [polypeptide binding]; other site 1399115007086 catalytic triad [active] 1399115007087 peroxidatic and resolving cysteines [active] 1399115007088 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1399115007089 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1399115007090 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1399115007091 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1399115007092 DNA binding residues [nucleotide binding] 1399115007093 dimer interface [polypeptide binding]; other site 1399115007094 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1399115007095 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1399115007096 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1399115007097 active site 1399115007098 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1399115007099 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1399115007100 GAF domain; Region: GAF_2; pfam13185 1399115007101 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1399115007102 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1399115007103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115007104 RNA binding surface [nucleotide binding]; other site 1399115007105 BioY family; Region: BioY; pfam02632 1399115007106 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1399115007107 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1399115007108 active site 1399115007109 HIGH motif; other site 1399115007110 dimer interface [polypeptide binding]; other site 1399115007111 KMSKS motif; other site 1399115007112 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115007113 RNA binding surface [nucleotide binding]; other site 1399115007114 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115007115 Transglycosylase; Region: Transgly; pfam00912 1399115007116 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1399115007117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1399115007118 acetyl-CoA synthetase; Provisional; Region: PRK04319 1399115007119 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1399115007120 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1399115007121 active site 1399115007122 acyl-activating enzyme (AAE) consensus motif; other site 1399115007123 putative CoA binding site [chemical binding]; other site 1399115007124 AMP binding site [chemical binding]; other site 1399115007125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007126 Coenzyme A binding pocket [chemical binding]; other site 1399115007127 FOG: CBS domain [General function prediction only]; Region: COG0517 1399115007128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1399115007129 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1399115007130 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1399115007131 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1399115007132 active site 1399115007133 Zn binding site [ion binding]; other site 1399115007134 YtkA-like; Region: YtkA; pfam13115 1399115007135 catabolite control protein A; Region: ccpA; TIGR01481 1399115007136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1399115007137 DNA binding site [nucleotide binding] 1399115007138 domain linker motif; other site 1399115007139 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1399115007140 dimerization interface [polypeptide binding]; other site 1399115007141 effector binding site; other site 1399115007142 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1399115007143 Chorismate mutase type II; Region: CM_2; cl00693 1399115007144 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1399115007145 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1399115007146 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1399115007147 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1399115007148 Ferritin-like domain; Region: Ferritin; pfam00210 1399115007149 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1399115007150 dimerization interface [polypeptide binding]; other site 1399115007151 DPS ferroxidase diiron center [ion binding]; other site 1399115007152 ion pore; other site 1399115007153 hypothetical protein; Provisional; Region: PRK04164 1399115007154 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115007155 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1399115007156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1399115007157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1399115007158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1399115007159 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1399115007160 putative tRNA-binding site [nucleotide binding]; other site 1399115007161 hypothetical protein; Provisional; Region: PRK13668 1399115007162 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1399115007163 catalytic residues [active] 1399115007164 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1399115007165 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1399115007166 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1399115007167 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1399115007168 oligomer interface [polypeptide binding]; other site 1399115007169 active site 1399115007170 metal binding site [ion binding]; metal-binding site 1399115007171 Predicted small secreted protein [Function unknown]; Region: COG5584 1399115007172 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1399115007173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115007174 S-adenosylmethionine binding site [chemical binding]; other site 1399115007175 acetolactate synthase; Reviewed; Region: PRK08617 1399115007176 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1399115007177 PYR/PP interface [polypeptide binding]; other site 1399115007178 dimer interface [polypeptide binding]; other site 1399115007179 TPP binding site [chemical binding]; other site 1399115007180 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1399115007181 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1399115007182 TPP-binding site [chemical binding]; other site 1399115007183 dimer interface [polypeptide binding]; other site 1399115007184 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1399115007185 Phosphotransferase enzyme family; Region: APH; pfam01636 1399115007186 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1399115007187 active site 1399115007188 substrate binding site [chemical binding]; other site 1399115007189 ATP binding site [chemical binding]; other site 1399115007190 pullulanase, type I; Region: pulA_typeI; TIGR02104 1399115007191 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1399115007192 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1399115007193 Ca binding site [ion binding]; other site 1399115007194 active site 1399115007195 catalytic site [active] 1399115007196 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1399115007197 sugar efflux transporter; Region: 2A0120; TIGR00899 1399115007198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115007199 putative substrate translocation pore; other site 1399115007200 dipeptidase PepV; Reviewed; Region: PRK07318 1399115007201 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1399115007202 active site 1399115007203 metal binding site [ion binding]; metal-binding site 1399115007204 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1399115007205 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1399115007206 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115007207 NAD(P) binding site [chemical binding]; other site 1399115007208 putative active site [active] 1399115007209 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1399115007210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1399115007211 RNA binding surface [nucleotide binding]; other site 1399115007212 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1399115007213 active site 1399115007214 uracil binding [chemical binding]; other site 1399115007215 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1399115007216 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1399115007217 HI0933-like protein; Region: HI0933_like; pfam03486 1399115007218 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1399115007219 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1399115007220 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1399115007221 HIGH motif; other site 1399115007222 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1399115007223 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1399115007224 active site 1399115007225 KMSKS motif; other site 1399115007226 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1399115007227 tRNA binding surface [nucleotide binding]; other site 1399115007228 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115007229 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1399115007230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115007231 motif II; other site 1399115007232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1399115007233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115007234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115007235 putative substrate translocation pore; other site 1399115007236 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1399115007237 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1399115007238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115007239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115007240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007241 Coenzyme A binding pocket [chemical binding]; other site 1399115007242 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1399115007243 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1399115007244 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1399115007245 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1399115007246 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1399115007247 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1399115007248 active site 1399115007249 substrate-binding site [chemical binding]; other site 1399115007250 metal-binding site [ion binding] 1399115007251 ATP binding site [chemical binding]; other site 1399115007252 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1399115007253 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115007254 Esterase/lipase [General function prediction only]; Region: COG1647 1399115007255 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1399115007256 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1399115007257 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1399115007258 nudix motif; other site 1399115007259 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1399115007260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1399115007261 active site 1399115007262 dimer interface [polypeptide binding]; other site 1399115007263 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1399115007264 dimer interface [polypeptide binding]; other site 1399115007265 active site 1399115007266 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1399115007267 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1399115007268 dimer interface [polypeptide binding]; other site 1399115007269 active site 1399115007270 metal binding site [ion binding]; metal-binding site 1399115007271 general stress protein 13; Validated; Region: PRK08059 1399115007272 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1399115007273 RNA binding site [nucleotide binding]; other site 1399115007274 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1399115007275 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1399115007276 dimer interface [polypeptide binding]; other site 1399115007277 putative radical transfer pathway; other site 1399115007278 diiron center [ion binding]; other site 1399115007279 tyrosyl radical; other site 1399115007280 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1399115007281 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 1399115007282 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1399115007283 active site 1399115007284 dimer interface [polypeptide binding]; other site 1399115007285 catalytic residues [active] 1399115007286 effector binding site; other site 1399115007287 R2 peptide binding site; other site 1399115007288 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1399115007289 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1399115007290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1399115007291 active site 1399115007292 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1399115007293 AsnC family; Region: AsnC_trans_reg; pfam01037 1399115007294 hypothetical protein; Validated; Region: PRK07682 1399115007295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1399115007296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115007297 homodimer interface [polypeptide binding]; other site 1399115007298 catalytic residue [active] 1399115007299 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1399115007300 homodimer interface [polypeptide binding]; other site 1399115007301 metal binding site [ion binding]; metal-binding site 1399115007302 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1399115007303 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1399115007304 Protein of unknown function (DUF429); Region: DUF429; cl12046 1399115007305 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1399115007306 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1399115007307 interface (dimer of trimers) [polypeptide binding]; other site 1399115007308 Substrate-binding/catalytic site; other site 1399115007309 Zn-binding sites [ion binding]; other site 1399115007310 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1399115007311 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1399115007312 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1399115007313 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1399115007314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115007315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115007316 putative substrate translocation pore; other site 1399115007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115007318 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1399115007319 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115007320 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115007321 active site turn [active] 1399115007322 phosphorylation site [posttranslational modification] 1399115007323 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1399115007324 HPr interaction site; other site 1399115007325 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1399115007326 active site 1399115007327 phosphorylation site [posttranslational modification] 1399115007328 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115007329 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1399115007330 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115007331 active site turn [active] 1399115007332 phosphorylation site [posttranslational modification] 1399115007333 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1399115007334 CAT RNA binding domain; Region: CAT_RBD; smart01061 1399115007335 PRD domain; Region: PRD; pfam00874 1399115007336 PRD domain; Region: PRD; pfam00874 1399115007337 Putative membrane protein; Region: YuiB; pfam14068 1399115007338 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1399115007339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115007340 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1399115007341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115007342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115007343 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115007344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007345 Coenzyme A binding pocket [chemical binding]; other site 1399115007346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115007347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007348 Coenzyme A binding pocket [chemical binding]; other site 1399115007349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115007350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1399115007351 NAD(P) binding site [chemical binding]; other site 1399115007352 active site 1399115007353 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1399115007354 Predicted membrane protein [Function unknown]; Region: COG3601 1399115007355 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1399115007356 hypothetical protein; Provisional; Region: PRK13669 1399115007357 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1399115007358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115007359 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 1399115007360 NifU-like domain; Region: NifU; cl00484 1399115007361 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1399115007362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115007363 active site 1399115007364 motif I; other site 1399115007365 motif II; other site 1399115007366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115007367 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1399115007368 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1399115007369 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1399115007370 putative active site [active] 1399115007371 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1399115007372 Heat induced stress protein YflT; Region: YflT; pfam11181 1399115007373 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1399115007374 lipoyl synthase; Provisional; Region: PRK05481 1399115007375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115007376 FeS/SAM binding site; other site 1399115007377 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1399115007378 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1399115007379 active site 1399115007380 metal binding site [ion binding]; metal-binding site 1399115007381 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1399115007382 Protein of unknown function DUF72; Region: DUF72; pfam01904 1399115007383 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1399115007384 RibD C-terminal domain; Region: RibD_C; cl17279 1399115007385 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1399115007386 FeS assembly protein SufB; Region: sufB; TIGR01980 1399115007387 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1399115007388 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1399115007389 trimerization site [polypeptide binding]; other site 1399115007390 active site 1399115007391 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1399115007392 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1399115007393 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1399115007394 catalytic residue [active] 1399115007395 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1399115007396 FeS assembly protein SufD; Region: sufD; TIGR01981 1399115007397 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1399115007398 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1399115007399 Walker A/P-loop; other site 1399115007400 ATP binding site [chemical binding]; other site 1399115007401 Q-loop/lid; other site 1399115007402 ABC transporter signature motif; other site 1399115007403 Walker B; other site 1399115007404 D-loop; other site 1399115007405 H-loop/switch region; other site 1399115007406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115007407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115007408 putative substrate translocation pore; other site 1399115007409 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1399115007410 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1399115007411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115007412 dimer interface [polypeptide binding]; other site 1399115007413 conserved gate region; other site 1399115007414 ABC-ATPase subunit interface; other site 1399115007415 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1399115007416 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1399115007417 Walker A/P-loop; other site 1399115007418 ATP binding site [chemical binding]; other site 1399115007419 Q-loop/lid; other site 1399115007420 ABC transporter signature motif; other site 1399115007421 Walker B; other site 1399115007422 D-loop; other site 1399115007423 H-loop/switch region; other site 1399115007424 NIL domain; Region: NIL; pfam09383 1399115007425 cystathionine beta-lyase; Provisional; Region: PRK07671 1399115007426 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1399115007427 homodimer interface [polypeptide binding]; other site 1399115007428 substrate-cofactor binding pocket; other site 1399115007429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115007430 catalytic residue [active] 1399115007431 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1399115007432 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1399115007433 dimer interface [polypeptide binding]; other site 1399115007434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115007435 catalytic residue [active] 1399115007436 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1399115007437 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1399115007438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115007439 S-adenosylmethionine binding site [chemical binding]; other site 1399115007440 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1399115007441 catalytic residues [active] 1399115007442 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1399115007443 lipoyl attachment site [posttranslational modification]; other site 1399115007444 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1399115007445 ArsC family; Region: ArsC; pfam03960 1399115007446 putative ArsC-like catalytic residues; other site 1399115007447 putative TRX-like catalytic residues [active] 1399115007448 DinB superfamily; Region: DinB_2; pfam12867 1399115007449 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1399115007450 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1399115007451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1399115007452 active site 1399115007453 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1399115007454 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1399115007455 dimer interface [polypeptide binding]; other site 1399115007456 active site 1399115007457 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1399115007458 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1399115007459 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1399115007460 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1399115007461 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1399115007462 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1399115007463 substrate binding site [chemical binding]; other site 1399115007464 oxyanion hole (OAH) forming residues; other site 1399115007465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115007466 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1399115007467 Proline dehydrogenase; Region: Pro_dh; cl03282 1399115007468 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1399115007469 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115007470 Haemolysin-III related; Region: HlyIII; cl03831 1399115007471 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1399115007472 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1399115007473 metal binding site [ion binding]; metal-binding site 1399115007474 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1399115007475 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1399115007476 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1399115007477 substrate binding site [chemical binding]; other site 1399115007478 glutamase interaction surface [polypeptide binding]; other site 1399115007479 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1399115007480 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1399115007481 catalytic residues [active] 1399115007482 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1399115007483 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1399115007484 putative active site [active] 1399115007485 oxyanion strand; other site 1399115007486 catalytic triad [active] 1399115007487 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1399115007488 putative active site pocket [active] 1399115007489 4-fold oligomerization interface [polypeptide binding]; other site 1399115007490 metal binding residues [ion binding]; metal-binding site 1399115007491 3-fold/trimer interface [polypeptide binding]; other site 1399115007492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1399115007493 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1399115007494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115007495 homodimer interface [polypeptide binding]; other site 1399115007496 catalytic residue [active] 1399115007497 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1399115007498 histidinol dehydrogenase; Region: hisD; TIGR00069 1399115007499 NAD binding site [chemical binding]; other site 1399115007500 dimerization interface [polypeptide binding]; other site 1399115007501 product binding site; other site 1399115007502 substrate binding site [chemical binding]; other site 1399115007503 zinc binding site [ion binding]; other site 1399115007504 catalytic residues [active] 1399115007505 ATP phosphoribosyltransferase; Region: HisG; cl15266 1399115007506 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1399115007507 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1399115007508 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1399115007509 motif 1; other site 1399115007510 dimer interface [polypeptide binding]; other site 1399115007511 active site 1399115007512 motif 2; other site 1399115007513 motif 3; other site 1399115007514 histidinol-phosphatase; Reviewed; Region: PRK08123 1399115007515 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1399115007516 active site 1399115007517 dimer interface [polypeptide binding]; other site 1399115007518 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1399115007519 tetramer interface [polypeptide binding]; other site 1399115007520 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1399115007521 active site 1399115007522 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1399115007523 active site 1399115007524 dimer interface [polypeptide binding]; other site 1399115007525 magnesium binding site [ion binding]; other site 1399115007526 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115007527 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115007528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115007529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007530 Coenzyme A binding pocket [chemical binding]; other site 1399115007531 Protein of unknown function DUF262; Region: DUF262; pfam03235 1399115007532 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1399115007533 Protein of unknown function DUF262; Region: DUF262; pfam03235 1399115007534 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1399115007535 SmpB-tmRNA interface; other site 1399115007536 ribonuclease R; Region: RNase_R; TIGR02063 1399115007537 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1399115007538 RNB domain; Region: RNB; pfam00773 1399115007539 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1399115007540 RNA binding site [nucleotide binding]; other site 1399115007541 Esterase/lipase [General function prediction only]; Region: COG1647 1399115007542 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1399115007543 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1399115007544 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1399115007545 ligand binding site [chemical binding]; other site 1399115007546 dimerization interface [polypeptide binding]; other site 1399115007547 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1399115007548 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1399115007549 TM-ABC transporter signature motif; other site 1399115007550 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1399115007551 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1399115007552 Walker A/P-loop; other site 1399115007553 ATP binding site [chemical binding]; other site 1399115007554 Q-loop/lid; other site 1399115007555 ABC transporter signature motif; other site 1399115007556 Walker B; other site 1399115007557 D-loop; other site 1399115007558 H-loop/switch region; other site 1399115007559 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1399115007560 D-ribose pyranase; Provisional; Region: PRK11797 1399115007561 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1399115007562 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1399115007563 substrate binding site [chemical binding]; other site 1399115007564 dimer interface [polypeptide binding]; other site 1399115007565 ATP binding site [chemical binding]; other site 1399115007566 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1399115007567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1399115007568 DNA binding site [nucleotide binding] 1399115007569 domain linker motif; other site 1399115007570 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1399115007571 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1399115007572 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1399115007573 homodimer interface [polypeptide binding]; other site 1399115007574 putative substrate binding pocket [chemical binding]; other site 1399115007575 diiron center [ion binding]; other site 1399115007576 enolase; Provisional; Region: eno; PRK00077 1399115007577 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1399115007578 dimer interface [polypeptide binding]; other site 1399115007579 metal binding site [ion binding]; metal-binding site 1399115007580 substrate binding pocket [chemical binding]; other site 1399115007581 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1399115007582 phosphoglyceromutase; Provisional; Region: PRK05434 1399115007583 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1399115007584 triosephosphate isomerase; Provisional; Region: PRK14565 1399115007585 substrate binding site [chemical binding]; other site 1399115007586 dimer interface [polypeptide binding]; other site 1399115007587 catalytic triad [active] 1399115007588 Phosphoglycerate kinase; Region: PGK; pfam00162 1399115007589 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1399115007590 substrate binding site [chemical binding]; other site 1399115007591 hinge regions; other site 1399115007592 ADP binding site [chemical binding]; other site 1399115007593 catalytic site [active] 1399115007594 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1399115007595 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1399115007596 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1399115007597 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1399115007598 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1399115007599 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1399115007600 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1399115007601 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1399115007602 Clp protease; Region: CLP_protease; pfam00574 1399115007603 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1399115007604 oligomer interface [polypeptide binding]; other site 1399115007605 active site residues [active] 1399115007606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1399115007607 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1399115007608 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1399115007609 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1399115007610 phosphate binding site [ion binding]; other site 1399115007611 putative substrate binding pocket [chemical binding]; other site 1399115007612 dimer interface [polypeptide binding]; other site 1399115007613 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1399115007614 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1399115007615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115007616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115007617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1399115007618 binding surface 1399115007619 TPR motif; other site 1399115007620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1399115007621 binding surface 1399115007622 TPR motif; other site 1399115007623 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1399115007624 Kinase associated protein B; Region: KapB; pfam08810 1399115007625 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1399115007626 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1399115007627 trimer interface [polypeptide binding]; other site 1399115007628 active site 1399115007629 substrate binding site [chemical binding]; other site 1399115007630 CoA binding site [chemical binding]; other site 1399115007631 pyrophosphatase PpaX; Provisional; Region: PRK13288 1399115007632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115007633 motif II; other site 1399115007634 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1399115007635 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1399115007636 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1399115007637 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1399115007638 Hpr binding site; other site 1399115007639 active site 1399115007640 homohexamer subunit interaction site [polypeptide binding]; other site 1399115007641 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1399115007642 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1399115007643 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1399115007644 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1399115007645 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1399115007646 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1399115007647 excinuclease ABC subunit B; Provisional; Region: PRK05298 1399115007648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115007649 ATP binding site [chemical binding]; other site 1399115007650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115007651 nucleotide binding region [chemical binding]; other site 1399115007652 ATP-binding site [chemical binding]; other site 1399115007653 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1399115007654 UvrB/uvrC motif; Region: UVR; pfam02151 1399115007655 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1399115007656 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1399115007657 C-terminal peptidase (prc); Region: prc; TIGR00225 1399115007658 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1399115007659 protein binding site [polypeptide binding]; other site 1399115007660 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1399115007661 Catalytic dyad [active] 1399115007662 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1399115007663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1399115007664 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1399115007665 Peptidase family M23; Region: Peptidase_M23; pfam01551 1399115007666 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1399115007667 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1399115007668 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1399115007669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115007670 Walker A/P-loop; other site 1399115007671 ATP binding site [chemical binding]; other site 1399115007672 Q-loop/lid; other site 1399115007673 ABC transporter signature motif; other site 1399115007674 Walker B; other site 1399115007675 D-loop; other site 1399115007676 H-loop/switch region; other site 1399115007677 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1399115007678 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1399115007679 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115007680 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115007681 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115007682 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115007683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007684 Coenzyme A binding pocket [chemical binding]; other site 1399115007685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115007686 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1399115007687 S-adenosylmethionine binding site [chemical binding]; other site 1399115007688 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1399115007689 PCRF domain; Region: PCRF; pfam03462 1399115007690 RF-1 domain; Region: RF-1; pfam00472 1399115007691 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1399115007692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1399115007693 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1399115007694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1399115007695 nucleotide binding region [chemical binding]; other site 1399115007696 ATP-binding site [chemical binding]; other site 1399115007697 SEC-C motif; Region: SEC-C; pfam02810 1399115007698 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1399115007699 30S subunit binding site; other site 1399115007700 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115007701 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1399115007702 DNA-binding site [nucleotide binding]; DNA binding site 1399115007703 RNA-binding motif; other site 1399115007704 ComK protein; Region: ComK; pfam06338 1399115007705 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1399115007706 Flagellar protein FliS; Region: FliS; cl00654 1399115007707 flagellin; Provisional; Region: PRK12804 1399115007708 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1399115007709 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1399115007710 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1399115007711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 1399115007712 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1399115007713 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115007714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115007715 metal binding site [ion binding]; metal-binding site 1399115007716 active site 1399115007717 I-site; other site 1399115007718 Quinolinate synthetase A protein; Region: NadA; cl00420 1399115007719 Flagellar protein FliS; Region: FliS; cl00654 1399115007720 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1399115007721 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1399115007722 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1399115007723 FlaG protein; Region: FlaG; cl00591 1399115007724 Helix-turn-helix domain; Region: HTH_28; pfam13518 1399115007725 pseudaminic acid synthase; Region: PseI; TIGR03586 1399115007726 NeuB family; Region: NeuB; pfam03102 1399115007727 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1399115007728 NeuB binding interface [polypeptide binding]; other site 1399115007729 putative substrate binding site [chemical binding]; other site 1399115007730 WbqC-like protein family; Region: WbqC; pfam08889 1399115007731 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1399115007732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1399115007733 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1399115007734 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1399115007735 ligand binding site; other site 1399115007736 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1399115007737 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1399115007738 inhibitor-cofactor binding pocket; inhibition site 1399115007739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115007740 catalytic residue [active] 1399115007741 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1399115007742 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1399115007743 NAD(P) binding site [chemical binding]; other site 1399115007744 homodimer interface [polypeptide binding]; other site 1399115007745 substrate binding site [chemical binding]; other site 1399115007746 active site 1399115007747 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1399115007748 flagellin; Provisional; Region: PRK12804 1399115007749 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1399115007750 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1399115007751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1399115007752 dimerization interface [polypeptide binding]; other site 1399115007753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115007754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115007755 dimer interface [polypeptide binding]; other site 1399115007756 putative CheW interface [polypeptide binding]; other site 1399115007757 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1399115007758 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1399115007759 peptide binding site [polypeptide binding]; other site 1399115007760 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115007761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007762 Coenzyme A binding pocket [chemical binding]; other site 1399115007763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1399115007764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115007765 Coenzyme A binding pocket [chemical binding]; other site 1399115007766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115007767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115007768 dimerization interface [polypeptide binding]; other site 1399115007769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115007770 dimer interface [polypeptide binding]; other site 1399115007771 phosphorylation site [posttranslational modification] 1399115007772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115007773 ATP binding site [chemical binding]; other site 1399115007774 Mg2+ binding site [ion binding]; other site 1399115007775 G-X-G motif; other site 1399115007776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115007777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115007778 active site 1399115007779 phosphorylation site [posttranslational modification] 1399115007780 intermolecular recognition site; other site 1399115007781 dimerization interface [polypeptide binding]; other site 1399115007782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115007783 DNA binding site [nucleotide binding] 1399115007784 PAS domain S-box; Region: sensory_box; TIGR00229 1399115007785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115007786 putative active site [active] 1399115007787 heme pocket [chemical binding]; other site 1399115007788 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1399115007789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115007790 putative active site [active] 1399115007791 heme pocket [chemical binding]; other site 1399115007792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115007793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115007794 metal binding site [ion binding]; metal-binding site 1399115007795 active site 1399115007796 I-site; other site 1399115007797 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115007798 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115007799 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115007800 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1399115007801 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115007802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1399115007803 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 1399115007804 substrate binding pocket [chemical binding]; other site 1399115007805 substrate-Mg2+ binding site; other site 1399115007806 aspartate-rich region 1; other site 1399115007807 aspartate-rich region 2; other site 1399115007808 carbon storage regulator; Provisional; Region: PRK01712 1399115007809 flagellar assembly protein FliW; Provisional; Region: PRK13285 1399115007810 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1399115007811 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1399115007812 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1399115007813 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1399115007814 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1399115007815 FlgN protein; Region: FlgN; pfam05130 1399115007816 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1399115007817 flagellar operon protein TIGR03826; Region: YvyF 1399115007818 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1399115007819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115007820 active site 1399115007821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115007822 ATP binding site [chemical binding]; other site 1399115007823 putative Mg++ binding site [ion binding]; other site 1399115007824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115007825 nucleotide binding region [chemical binding]; other site 1399115007826 ATP-binding site [chemical binding]; other site 1399115007827 EDD domain protein, DegV family; Region: DegV; TIGR00762 1399115007828 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1399115007829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1399115007830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115007831 active site 1399115007832 phosphorylation site [posttranslational modification] 1399115007833 intermolecular recognition site; other site 1399115007834 dimerization interface [polypeptide binding]; other site 1399115007835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1399115007836 DNA binding residues [nucleotide binding] 1399115007837 dimerization interface [polypeptide binding]; other site 1399115007838 Sensor protein DegS; Region: DegS; pfam05384 1399115007839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1399115007840 Histidine kinase; Region: HisKA_3; pfam07730 1399115007841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115007842 ATP binding site [chemical binding]; other site 1399115007843 Mg2+ binding site [ion binding]; other site 1399115007844 G-X-G motif; other site 1399115007845 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1399115007846 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1399115007847 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1399115007848 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1399115007849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115007850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115007851 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1399115007852 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1399115007853 Chromate transporter; Region: Chromate_transp; pfam02417 1399115007854 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1399115007855 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1399115007856 Mg++ binding site [ion binding]; other site 1399115007857 putative catalytic motif [active] 1399115007858 substrate binding site [chemical binding]; other site 1399115007859 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1399115007860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1399115007861 ATP binding site [chemical binding]; other site 1399115007862 putative Mg++ binding site [ion binding]; other site 1399115007863 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1399115007864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1399115007865 nucleotide binding region [chemical binding]; other site 1399115007866 ATP-binding site [chemical binding]; other site 1399115007867 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1399115007868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115007869 motif II; other site 1399115007870 Asp23 family; Region: Asp23; pfam03780 1399115007871 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1399115007872 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1399115007873 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1399115007874 active site 1399115007875 catalytic triad [active] 1399115007876 oxyanion hole [active] 1399115007877 Predicted esterase [General function prediction only]; Region: COG0400 1399115007878 putative hydrolase; Provisional; Region: PRK11460 1399115007879 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1399115007880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115007881 Zn binding site [ion binding]; other site 1399115007882 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1399115007883 Zn binding site [ion binding]; other site 1399115007884 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1399115007885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115007886 Walker A/P-loop; other site 1399115007887 ATP binding site [chemical binding]; other site 1399115007888 Q-loop/lid; other site 1399115007889 ABC transporter signature motif; other site 1399115007890 Walker B; other site 1399115007891 D-loop; other site 1399115007892 H-loop/switch region; other site 1399115007893 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1399115007894 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1399115007895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115007896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115007897 non-specific DNA binding site [nucleotide binding]; other site 1399115007898 salt bridge; other site 1399115007899 sequence-specific DNA binding site [nucleotide binding]; other site 1399115007900 FtsX-like permease family; Region: FtsX; pfam02687 1399115007901 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115007902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115007903 Walker A/P-loop; other site 1399115007904 ATP binding site [chemical binding]; other site 1399115007905 Q-loop/lid; other site 1399115007906 ABC transporter signature motif; other site 1399115007907 Walker B; other site 1399115007908 D-loop; other site 1399115007909 H-loop/switch region; other site 1399115007910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115007911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1399115007912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115007913 ATP binding site [chemical binding]; other site 1399115007914 Mg2+ binding site [ion binding]; other site 1399115007915 G-X-G motif; other site 1399115007916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115007917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115007918 active site 1399115007919 phosphorylation site [posttranslational modification] 1399115007920 intermolecular recognition site; other site 1399115007921 dimerization interface [polypeptide binding]; other site 1399115007922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115007923 DNA binding site [nucleotide binding] 1399115007924 FtsX-like permease family; Region: FtsX; pfam02687 1399115007925 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115007926 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115007927 Walker A/P-loop; other site 1399115007928 ATP binding site [chemical binding]; other site 1399115007929 Q-loop/lid; other site 1399115007930 ABC transporter signature motif; other site 1399115007931 Walker B; other site 1399115007932 D-loop; other site 1399115007933 H-loop/switch region; other site 1399115007934 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1399115007935 HPr interaction site; other site 1399115007936 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1399115007937 active site 1399115007938 phosphorylation site [posttranslational modification] 1399115007939 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1399115007940 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1399115007941 active site 1399115007942 Zn binding site [ion binding]; other site 1399115007943 PAS domain; Region: PAS; smart00091 1399115007944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115007945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115007946 metal binding site [ion binding]; metal-binding site 1399115007947 active site 1399115007948 I-site; other site 1399115007949 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115007950 FOG: CBS domain [General function prediction only]; Region: COG0517 1399115007951 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1399115007952 Cache domain; Region: Cache_1; pfam02743 1399115007953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115007954 dimerization interface [polypeptide binding]; other site 1399115007955 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1399115007956 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115007957 dimer interface [polypeptide binding]; other site 1399115007958 putative CheW interface [polypeptide binding]; other site 1399115007959 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1399115007960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1399115007961 active site 1399115007962 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1399115007963 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1399115007964 putative lipid kinase; Reviewed; Region: PRK13337 1399115007965 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1399115007966 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1399115007967 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1399115007968 GatB domain; Region: GatB_Yqey; smart00845 1399115007969 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1399115007970 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1399115007971 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1399115007972 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1399115007973 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1399115007974 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1399115007975 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1399115007976 Na binding site [ion binding]; other site 1399115007977 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1399115007978 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1399115007979 Glutamate binding site [chemical binding]; other site 1399115007980 homodimer interface [polypeptide binding]; other site 1399115007981 NAD binding site [chemical binding]; other site 1399115007982 catalytic residues [active] 1399115007983 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1399115007984 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1399115007985 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1399115007986 catalytic triad [active] 1399115007987 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1399115007988 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1399115007989 peptide binding site [polypeptide binding]; other site 1399115007990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115007991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115007992 metal binding site [ion binding]; metal-binding site 1399115007993 active site 1399115007994 I-site; other site 1399115007995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1399115007996 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1399115007997 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1399115007998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1399115007999 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1399115008000 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1399115008001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115008002 dimer interface [polypeptide binding]; other site 1399115008003 conserved gate region; other site 1399115008004 putative PBP binding loops; other site 1399115008005 ABC-ATPase subunit interface; other site 1399115008006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115008007 dimer interface [polypeptide binding]; other site 1399115008008 conserved gate region; other site 1399115008009 putative PBP binding loops; other site 1399115008010 ABC-ATPase subunit interface; other site 1399115008011 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1399115008012 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1399115008013 Walker A/P-loop; other site 1399115008014 ATP binding site [chemical binding]; other site 1399115008015 Q-loop/lid; other site 1399115008016 ABC transporter signature motif; other site 1399115008017 Walker B; other site 1399115008018 D-loop; other site 1399115008019 H-loop/switch region; other site 1399115008020 TOBE domain; Region: TOBE_2; pfam08402 1399115008021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115008022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115008023 non-specific DNA binding site [nucleotide binding]; other site 1399115008024 salt bridge; other site 1399115008025 sequence-specific DNA binding site [nucleotide binding]; other site 1399115008026 Cupin domain; Region: Cupin_2; pfam07883 1399115008027 EDD domain protein, DegV family; Region: DegV; TIGR00762 1399115008028 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1399115008029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1399115008030 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1399115008031 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1399115008032 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1399115008033 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115008034 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115008035 metal binding site [ion binding]; metal-binding site 1399115008036 active site 1399115008037 I-site; other site 1399115008038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115008039 Putative zinc-finger; Region: zf-HC2; pfam13490 1399115008040 putative anti-sigmaE protein; Provisional; Region: PRK13920 1399115008041 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1399115008042 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1399115008043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115008044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115008045 DNA binding residues [nucleotide binding] 1399115008046 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1399115008047 putative homodimer interface [polypeptide binding]; other site 1399115008048 putative homotetramer interface [polypeptide binding]; other site 1399115008049 putative metal binding site [ion binding]; other site 1399115008050 putative homodimer-homodimer interface [polypeptide binding]; other site 1399115008051 putative allosteric switch controlling residues; other site 1399115008052 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1399115008053 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1399115008054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1399115008055 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1399115008056 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1399115008057 Ca binding site [ion binding]; other site 1399115008058 active site 1399115008059 catalytic site [active] 1399115008060 transaminase; Reviewed; Region: PRK08068 1399115008061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1399115008062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115008063 homodimer interface [polypeptide binding]; other site 1399115008064 catalytic residue [active] 1399115008065 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1399115008066 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1399115008067 Walker A/P-loop; other site 1399115008068 ATP binding site [chemical binding]; other site 1399115008069 Q-loop/lid; other site 1399115008070 ABC transporter signature motif; other site 1399115008071 Walker B; other site 1399115008072 D-loop; other site 1399115008073 H-loop/switch region; other site 1399115008074 NIL domain; Region: NIL; pfam09383 1399115008075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115008076 dimer interface [polypeptide binding]; other site 1399115008077 conserved gate region; other site 1399115008078 ABC-ATPase subunit interface; other site 1399115008079 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1399115008080 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1399115008081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1399115008082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115008083 Coenzyme A binding pocket [chemical binding]; other site 1399115008084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1399115008085 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1399115008086 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1399115008087 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1399115008088 Fn3 associated; Region: Fn3_assoc; pfam13287 1399115008089 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1399115008090 generic binding surface II; other site 1399115008091 generic binding surface I; other site 1399115008092 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1399115008093 putative active site [active] 1399115008094 putative catalytic site [active] 1399115008095 putative Mg binding site IVb [ion binding]; other site 1399115008096 putative phosphate binding site [ion binding]; other site 1399115008097 putative DNA binding site [nucleotide binding]; other site 1399115008098 putative Mg binding site IVa [ion binding]; other site 1399115008099 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1399115008100 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1399115008101 catalytic residues [active] 1399115008102 Bacterial SH3 domain; Region: SH3_3; cl17532 1399115008103 Bacterial SH3 domain; Region: SH3_3; cl17532 1399115008104 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115008105 Bacterial SH3 domain; Region: SH3_3; cl17532 1399115008106 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1399115008107 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115008108 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1399115008109 Lysozyme subfamily 2; Region: LYZ2; smart00047 1399115008110 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1399115008111 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1399115008112 Ligand Binding Site [chemical binding]; other site 1399115008113 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1399115008114 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1399115008115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1399115008116 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1399115008117 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1399115008118 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1399115008119 catalytic residues [active] 1399115008120 dimer interface [polypeptide binding]; other site 1399115008121 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1399115008122 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1399115008123 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1399115008124 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1399115008125 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1399115008126 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1399115008127 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1399115008128 Bacterial SH3 domain; Region: SH3_3; cl17532 1399115008129 Bacterial SH3 domain; Region: SH3_3; cl17532 1399115008130 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1399115008131 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1399115008132 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1399115008133 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1399115008134 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1399115008135 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1399115008136 inhibitor-cofactor binding pocket; inhibition site 1399115008137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115008138 catalytic residue [active] 1399115008139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1399115008140 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1399115008141 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1399115008142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1399115008143 putative ADP-binding pocket [chemical binding]; other site 1399115008144 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1399115008145 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1399115008146 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1399115008147 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1399115008148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1399115008149 active site 1399115008150 AMP binding site [chemical binding]; other site 1399115008151 acyl-activating enzyme (AAE) consensus motif; other site 1399115008152 CoA binding site [chemical binding]; other site 1399115008153 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1399115008154 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1399115008155 putative NAD(P) binding site [chemical binding]; other site 1399115008156 active site 1399115008157 putative substrate binding site [chemical binding]; other site 1399115008158 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1399115008159 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1399115008160 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1399115008161 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1399115008162 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1399115008163 NAD(P) binding site [chemical binding]; other site 1399115008164 homodimer interface [polypeptide binding]; other site 1399115008165 substrate binding site [chemical binding]; other site 1399115008166 active site 1399115008167 Chain length determinant protein; Region: Wzz; cl15801 1399115008168 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1399115008169 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1399115008170 VanZ like family; Region: VanZ; pfam04892 1399115008171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115008172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115008173 non-specific DNA binding site [nucleotide binding]; other site 1399115008174 salt bridge; other site 1399115008175 sequence-specific DNA binding site [nucleotide binding]; other site 1399115008176 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115008177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115008178 non-specific DNA binding site [nucleotide binding]; other site 1399115008179 salt bridge; other site 1399115008180 sequence-specific DNA binding site [nucleotide binding]; other site 1399115008181 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1399115008182 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1399115008183 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1399115008184 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1399115008185 Walker A/P-loop; other site 1399115008186 ATP binding site [chemical binding]; other site 1399115008187 Q-loop/lid; other site 1399115008188 ABC transporter signature motif; other site 1399115008189 Walker B; other site 1399115008190 D-loop; other site 1399115008191 H-loop/switch region; other site 1399115008192 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1399115008193 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1399115008194 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1399115008195 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1399115008196 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1399115008197 active site 1399115008198 metal binding site [ion binding]; metal-binding site 1399115008199 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1399115008200 Peptidase family M48; Region: Peptidase_M48; cl12018 1399115008201 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1399115008202 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1399115008203 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1399115008204 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1399115008205 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1399115008206 putative di-iron ligands [ion binding]; other site 1399115008207 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1399115008208 UDP-glucose 4-epimerase; Region: PLN02240 1399115008209 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1399115008210 NAD binding site [chemical binding]; other site 1399115008211 homodimer interface [polypeptide binding]; other site 1399115008212 active site 1399115008213 substrate binding site [chemical binding]; other site 1399115008214 Predicted membrane protein [Function unknown]; Region: COG4267 1399115008215 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 1399115008216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1399115008217 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 1399115008218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 1399115008219 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 1399115008220 NodB motif; other site 1399115008221 putative active site [active] 1399115008222 putative catalytic site [active] 1399115008223 putative Zn binding site [ion binding]; other site 1399115008224 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1399115008225 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1399115008226 GAF domain; Region: GAF_3; pfam13492 1399115008227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115008228 metal binding site [ion binding]; metal-binding site 1399115008229 active site 1399115008230 I-site; other site 1399115008231 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1399115008232 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115008233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115008234 metal binding site [ion binding]; metal-binding site 1399115008235 active site 1399115008236 I-site; other site 1399115008237 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1399115008238 Nuclease-related domain; Region: NERD; pfam08378 1399115008239 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1399115008240 active site 1399115008241 tetramer interface; other site 1399115008242 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1399115008243 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1399115008244 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1399115008245 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1399115008246 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1399115008247 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1399115008248 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1399115008249 [2Fe-2S] cluster binding site [ion binding]; other site 1399115008250 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1399115008251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115008252 putative substrate translocation pore; other site 1399115008253 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1399115008254 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1399115008255 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 1399115008256 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 1399115008257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115008258 HAMP domain; Region: HAMP; pfam00672 1399115008259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008260 dimer interface [polypeptide binding]; other site 1399115008261 phosphorylation site [posttranslational modification] 1399115008262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008263 ATP binding site [chemical binding]; other site 1399115008264 Mg2+ binding site [ion binding]; other site 1399115008265 G-X-G motif; other site 1399115008266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115008267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115008268 active site 1399115008269 phosphorylation site [posttranslational modification] 1399115008270 intermolecular recognition site; other site 1399115008271 dimerization interface [polypeptide binding]; other site 1399115008272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115008273 DNA binding site [nucleotide binding] 1399115008274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115008275 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1399115008276 Walker A motif; other site 1399115008277 ATP binding site [chemical binding]; other site 1399115008278 Walker B motif; other site 1399115008279 arginine finger; other site 1399115008280 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1399115008281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115008282 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1399115008283 active site 1399115008284 DNA binding site [nucleotide binding] 1399115008285 Int/Topo IB signature motif; other site 1399115008286 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1399115008287 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1399115008288 active site 1399115008289 catalytic residues [active] 1399115008290 DNA binding site [nucleotide binding] 1399115008291 Int/Topo IB signature motif; other site 1399115008292 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1399115008293 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1399115008294 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1399115008295 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1399115008296 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1399115008297 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1399115008298 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1399115008299 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1399115008300 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1399115008301 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1399115008302 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1399115008303 DNA binding residues [nucleotide binding] 1399115008304 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1399115008305 active site 1399115008306 catalytic triad [active] 1399115008307 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1399115008308 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1399115008309 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1399115008310 active site 1399115008311 putative catalytic site [active] 1399115008312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115008313 putative Zn2+ binding site [ion binding]; other site 1399115008314 putative DNA binding site [nucleotide binding]; other site 1399115008315 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1399115008316 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1399115008317 CHASE3 domain; Region: CHASE3; cl05000 1399115008318 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1399115008319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008320 dimer interface [polypeptide binding]; other site 1399115008321 phosphorylation site [posttranslational modification] 1399115008322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008323 ATP binding site [chemical binding]; other site 1399115008324 Mg2+ binding site [ion binding]; other site 1399115008325 G-X-G motif; other site 1399115008326 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1399115008327 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1399115008328 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1399115008329 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1399115008330 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1399115008331 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1399115008332 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1399115008333 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1399115008334 PAS domain; Region: PAS_9; pfam13426 1399115008335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115008336 putative active site [active] 1399115008337 heme pocket [chemical binding]; other site 1399115008338 PAS fold; Region: PAS_3; pfam08447 1399115008339 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115008340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115008341 active site 1399115008342 I-site; other site 1399115008343 metal binding site [ion binding]; metal-binding site 1399115008344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1399115008345 drug efflux system protein MdtG; Provisional; Region: PRK09874 1399115008346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115008347 putative substrate translocation pore; other site 1399115008348 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1399115008349 MreB and similar proteins; Region: MreB_like; cd10225 1399115008350 nucleotide binding site [chemical binding]; other site 1399115008351 Mg binding site [ion binding]; other site 1399115008352 putative protofilament interaction site [polypeptide binding]; other site 1399115008353 RodZ interaction site [polypeptide binding]; other site 1399115008354 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1399115008355 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1399115008356 hinge; other site 1399115008357 active site 1399115008358 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1399115008359 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1399115008360 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1399115008361 gamma subunit interface [polypeptide binding]; other site 1399115008362 epsilon subunit interface [polypeptide binding]; other site 1399115008363 LBP interface [polypeptide binding]; other site 1399115008364 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1399115008365 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1399115008366 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1399115008367 alpha subunit interaction interface [polypeptide binding]; other site 1399115008368 Walker A motif; other site 1399115008369 ATP binding site [chemical binding]; other site 1399115008370 Walker B motif; other site 1399115008371 inhibitor binding site; inhibition site 1399115008372 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1399115008373 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1399115008374 core domain interface [polypeptide binding]; other site 1399115008375 delta subunit interface [polypeptide binding]; other site 1399115008376 epsilon subunit interface [polypeptide binding]; other site 1399115008377 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1399115008378 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1399115008379 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1399115008380 beta subunit interaction interface [polypeptide binding]; other site 1399115008381 Walker A motif; other site 1399115008382 ATP binding site [chemical binding]; other site 1399115008383 Walker B motif; other site 1399115008384 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1399115008385 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1399115008386 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1399115008387 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1399115008388 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1399115008389 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1399115008390 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1399115008391 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1399115008392 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1399115008393 active site 1399115008394 homodimer interface [polypeptide binding]; other site 1399115008395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1399115008396 active site 1399115008397 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1399115008398 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1399115008399 Walker A/P-loop; other site 1399115008400 ATP binding site [chemical binding]; other site 1399115008401 Q-loop/lid; other site 1399115008402 ABC transporter signature motif; other site 1399115008403 Walker B; other site 1399115008404 D-loop; other site 1399115008405 H-loop/switch region; other site 1399115008406 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1399115008407 FtsX-like permease family; Region: FtsX; pfam02687 1399115008408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115008409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115008410 dimerization interface [polypeptide binding]; other site 1399115008411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008412 dimer interface [polypeptide binding]; other site 1399115008413 phosphorylation site [posttranslational modification] 1399115008414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008415 ATP binding site [chemical binding]; other site 1399115008416 Mg2+ binding site [ion binding]; other site 1399115008417 G-X-G motif; other site 1399115008418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115008419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115008420 active site 1399115008421 phosphorylation site [posttranslational modification] 1399115008422 intermolecular recognition site; other site 1399115008423 dimerization interface [polypeptide binding]; other site 1399115008424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115008425 DNA binding site [nucleotide binding] 1399115008426 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1399115008427 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1399115008428 dimer interface [polypeptide binding]; other site 1399115008429 active site 1399115008430 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1399115008431 folate binding site [chemical binding]; other site 1399115008432 hypothetical protein; Provisional; Region: PRK13690 1399115008433 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1399115008434 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1399115008435 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1399115008436 active site 1399115008437 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1399115008438 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1399115008439 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1399115008440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115008441 S-adenosylmethionine binding site [chemical binding]; other site 1399115008442 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1399115008443 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1399115008444 RF-1 domain; Region: RF-1; pfam00472 1399115008445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1399115008446 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1399115008447 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1399115008448 nucleotide binding site [chemical binding]; other site 1399115008449 GrpE; Region: GrpE; pfam01025 1399115008450 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1399115008451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115008452 Walker A motif; other site 1399115008453 ATP binding site [chemical binding]; other site 1399115008454 Walker B motif; other site 1399115008455 arginine finger; other site 1399115008456 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1399115008457 HSP70 interaction site [polypeptide binding]; other site 1399115008458 DnaJ domain; Region: DnaJ; pfam00226 1399115008459 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1399115008460 Predicted transcriptional regulators [Transcription]; Region: COG1725 1399115008461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115008462 DNA-binding site [nucleotide binding]; DNA binding site 1399115008463 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115008464 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115008465 Walker A/P-loop; other site 1399115008466 ATP binding site [chemical binding]; other site 1399115008467 Q-loop/lid; other site 1399115008468 ABC transporter signature motif; other site 1399115008469 Walker B; other site 1399115008470 D-loop; other site 1399115008471 H-loop/switch region; other site 1399115008472 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1399115008473 dimer interface [polypeptide binding]; other site 1399115008474 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1399115008475 active site 1399115008476 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1399115008477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115008478 DNA-binding site [nucleotide binding]; DNA binding site 1399115008479 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1399115008480 UTRA domain; Region: UTRA; pfam07702 1399115008481 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1399115008482 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115008483 active site turn [active] 1399115008484 phosphorylation site [posttranslational modification] 1399115008485 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115008486 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1399115008487 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1399115008488 Ca binding site [ion binding]; other site 1399115008489 active site 1399115008490 catalytic site [active] 1399115008491 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1399115008492 amino acid carrier protein; Region: agcS; TIGR00835 1399115008493 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1399115008494 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1399115008495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115008496 dimerization interface [polypeptide binding]; other site 1399115008497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1399115008498 dimer interface [polypeptide binding]; other site 1399115008499 putative CheW interface [polypeptide binding]; other site 1399115008500 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1399115008501 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1399115008502 homopentamer interface [polypeptide binding]; other site 1399115008503 active site 1399115008504 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1399115008505 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1399115008506 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1399115008507 dimerization interface [polypeptide binding]; other site 1399115008508 active site 1399115008509 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1399115008510 Lumazine binding domain; Region: Lum_binding; pfam00677 1399115008511 Lumazine binding domain; Region: Lum_binding; pfam00677 1399115008512 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1399115008513 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1399115008514 catalytic motif [active] 1399115008515 Zn binding site [ion binding]; other site 1399115008516 RibD C-terminal domain; Region: RibD_C; pfam01872 1399115008517 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1399115008518 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1399115008519 metal binding site [ion binding]; metal-binding site 1399115008520 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1399115008521 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1399115008522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1399115008523 dimer interface [polypeptide binding]; other site 1399115008524 conserved gate region; other site 1399115008525 ABC-ATPase subunit interface; other site 1399115008526 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1399115008527 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1399115008528 Walker A/P-loop; other site 1399115008529 ATP binding site [chemical binding]; other site 1399115008530 Q-loop/lid; other site 1399115008531 ABC transporter signature motif; other site 1399115008532 Walker B; other site 1399115008533 D-loop; other site 1399115008534 H-loop/switch region; other site 1399115008535 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1399115008536 Esterase/lipase [General function prediction only]; Region: COG1647 1399115008537 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1399115008538 thymidine kinase; Provisional; Region: PRK04296 1399115008539 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1399115008540 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115008541 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1399115008542 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1399115008543 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1399115008544 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1399115008545 RNA binding site [nucleotide binding]; other site 1399115008546 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1399115008547 multimer interface [polypeptide binding]; other site 1399115008548 Walker A motif; other site 1399115008549 ATP binding site [chemical binding]; other site 1399115008550 Walker B motif; other site 1399115008551 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115008552 NlpC/P60 family; Region: NLPC_P60; pfam00877 1399115008553 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1399115008554 classical (c) SDRs; Region: SDR_c; cd05233 1399115008555 NAD(P) binding site [chemical binding]; other site 1399115008556 active site 1399115008557 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1399115008558 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1399115008559 putative active site [active] 1399115008560 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1399115008561 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1399115008562 hinge; other site 1399115008563 active site 1399115008564 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1399115008565 active site 1399115008566 intersubunit interactions; other site 1399115008567 catalytic residue [active] 1399115008568 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1399115008569 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1399115008570 intersubunit interface [polypeptide binding]; other site 1399115008571 active site 1399115008572 zinc binding site [ion binding]; other site 1399115008573 Na+ binding site [ion binding]; other site 1399115008574 Response regulator receiver domain; Region: Response_reg; pfam00072 1399115008575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115008576 active site 1399115008577 phosphorylation site [posttranslational modification] 1399115008578 intermolecular recognition site; other site 1399115008579 dimerization interface [polypeptide binding]; other site 1399115008580 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1399115008581 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1399115008582 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1399115008583 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1399115008584 beta-galactosidase; Region: BGL; TIGR03356 1399115008585 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1399115008586 active site 1399115008587 P-loop; other site 1399115008588 phosphorylation site [posttranslational modification] 1399115008589 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 1399115008590 active site 1399115008591 methionine cluster; other site 1399115008592 phosphorylation site [posttranslational modification] 1399115008593 metal binding site [ion binding]; metal-binding site 1399115008594 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1399115008595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115008596 DNA-binding site [nucleotide binding]; DNA binding site 1399115008597 UTRA domain; Region: UTRA; pfam07702 1399115008598 CTP synthetase; Validated; Region: pyrG; PRK05380 1399115008599 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1399115008600 Catalytic site [active] 1399115008601 active site 1399115008602 UTP binding site [chemical binding]; other site 1399115008603 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1399115008604 active site 1399115008605 putative oxyanion hole; other site 1399115008606 catalytic triad [active] 1399115008607 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1399115008608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1399115008609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115008610 Coenzyme A binding pocket [chemical binding]; other site 1399115008611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115008612 dimerization interface [polypeptide binding]; other site 1399115008613 putative DNA binding site [nucleotide binding]; other site 1399115008614 putative Zn2+ binding site [ion binding]; other site 1399115008615 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115008616 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1399115008617 Domain of unknown function (DUF336); Region: DUF336; cl01249 1399115008618 putative oxidoreductase; Provisional; Region: PRK11579 1399115008619 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1399115008620 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1399115008621 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1399115008622 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1399115008623 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1399115008624 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1399115008625 NADP binding site [chemical binding]; other site 1399115008626 active site 1399115008627 steroid binding site; other site 1399115008628 PAS domain S-box; Region: sensory_box; TIGR00229 1399115008629 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115008630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115008631 metal binding site [ion binding]; metal-binding site 1399115008632 active site 1399115008633 I-site; other site 1399115008634 Ion channel; Region: Ion_trans_2; pfam07885 1399115008635 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1399115008636 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1399115008637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1399115008638 Divalent cation transporter; Region: MgtE; pfam01769 1399115008639 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1399115008640 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1399115008641 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1399115008642 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115008643 dimer interface [polypeptide binding]; other site 1399115008644 ABC-ATPase subunit interface; other site 1399115008645 putative PBP binding regions; other site 1399115008646 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1399115008647 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1399115008648 metal binding site [ion binding]; metal-binding site 1399115008649 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 1399115008650 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1399115008651 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1399115008652 putative NAD(P) binding site [chemical binding]; other site 1399115008653 dimer interface [polypeptide binding]; other site 1399115008654 HAMP domain; Region: HAMP; pfam00672 1399115008655 dimerization interface [polypeptide binding]; other site 1399115008656 GAF domain; Region: GAF_3; pfam13492 1399115008657 PAS fold; Region: PAS; pfam00989 1399115008658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008659 dimer interface [polypeptide binding]; other site 1399115008660 phosphorylation site [posttranslational modification] 1399115008661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008662 ATP binding site [chemical binding]; other site 1399115008663 Mg2+ binding site [ion binding]; other site 1399115008664 G-X-G motif; other site 1399115008665 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1399115008666 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1399115008667 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1399115008668 Sulfatase; Region: Sulfatase; pfam00884 1399115008669 HEAT repeats; Region: HEAT_2; pfam13646 1399115008670 HEAT repeats; Region: HEAT_2; pfam13646 1399115008671 Lysine efflux permease [General function prediction only]; Region: COG1279 1399115008672 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1399115008673 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1399115008674 ring oligomerisation interface [polypeptide binding]; other site 1399115008675 ATP/Mg binding site [chemical binding]; other site 1399115008676 stacking interactions; other site 1399115008677 hinge regions; other site 1399115008678 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1399115008679 oligomerisation interface [polypeptide binding]; other site 1399115008680 mobile loop; other site 1399115008681 roof hairpin; other site 1399115008682 CAAX protease self-immunity; Region: Abi; pfam02517 1399115008683 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1399115008684 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1399115008685 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1399115008686 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1399115008687 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1399115008688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115008689 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1399115008690 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1399115008691 Walker A/P-loop; other site 1399115008692 ATP binding site [chemical binding]; other site 1399115008693 Q-loop/lid; other site 1399115008694 ABC transporter signature motif; other site 1399115008695 Walker B; other site 1399115008696 D-loop; other site 1399115008697 H-loop/switch region; other site 1399115008698 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1399115008699 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1399115008700 putative ligand binding residues [chemical binding]; other site 1399115008701 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1399115008702 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115008703 ABC-ATPase subunit interface; other site 1399115008704 dimer interface [polypeptide binding]; other site 1399115008705 putative PBP binding regions; other site 1399115008706 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1399115008707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1399115008708 ABC-ATPase subunit interface; other site 1399115008709 dimer interface [polypeptide binding]; other site 1399115008710 putative PBP binding regions; other site 1399115008711 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1399115008712 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1399115008713 putative active site [active] 1399115008714 catalytic triad [active] 1399115008715 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1399115008716 PA/protease or protease-like domain interface [polypeptide binding]; other site 1399115008717 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1399115008718 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1399115008719 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1399115008720 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1399115008721 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1399115008722 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1399115008723 CoA binding domain; Region: CoA_binding; pfam02629 1399115008724 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1399115008725 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115008726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115008727 Walker A/P-loop; other site 1399115008728 ATP binding site [chemical binding]; other site 1399115008729 Q-loop/lid; other site 1399115008730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115008731 ABC transporter signature motif; other site 1399115008732 Walker B; other site 1399115008733 D-loop; other site 1399115008734 ABC transporter; Region: ABC_tran_2; pfam12848 1399115008735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115008736 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1399115008737 Predicted membrane protein [Function unknown]; Region: COG2259 1399115008738 Predicted transcriptional regulators [Transcription]; Region: COG1733 1399115008739 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1399115008740 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1399115008741 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1399115008742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115008743 motif II; other site 1399115008744 UGMP family protein; Validated; Region: PRK09604 1399115008745 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1399115008746 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1399115008747 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1399115008748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115008749 Coenzyme A binding pocket [chemical binding]; other site 1399115008750 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1399115008751 Glycoprotease family; Region: Peptidase_M22; pfam00814 1399115008752 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1399115008753 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1399115008754 nudix motif; other site 1399115008755 hypothetical protein; Provisional; Region: PRK04351 1399115008756 SprT homologues; Region: SprT; cl01182 1399115008757 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1399115008758 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1399115008759 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1399115008760 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1399115008761 RNA binding site [nucleotide binding]; other site 1399115008762 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1399115008763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1399115008764 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1399115008765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1399115008766 DNA binding residues [nucleotide binding] 1399115008767 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1399115008768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008769 ATP binding site [chemical binding]; other site 1399115008770 Mg2+ binding site [ion binding]; other site 1399115008771 G-X-G motif; other site 1399115008772 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1399115008773 anti sigma factor interaction site; other site 1399115008774 regulatory phosphorylation site [posttranslational modification]; other site 1399115008775 PemK-like protein; Region: PemK; pfam02452 1399115008776 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1399115008777 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1399115008778 active site 1399115008779 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1399115008780 dimer interface [polypeptide binding]; other site 1399115008781 substrate binding site [chemical binding]; other site 1399115008782 catalytic residues [active] 1399115008783 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1399115008784 Rhomboid family; Region: Rhomboid; pfam01694 1399115008785 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1399115008786 aromatic arch; other site 1399115008787 DCoH dimer interaction site [polypeptide binding]; other site 1399115008788 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1399115008789 DCoH tetramer interaction site [polypeptide binding]; other site 1399115008790 substrate binding site [chemical binding]; other site 1399115008791 Isochorismatase family; Region: Isochorismatase; pfam00857 1399115008792 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1399115008793 catalytic triad [active] 1399115008794 conserved cis-peptide bond; other site 1399115008795 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1399115008796 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1399115008797 active site 1399115008798 YwpF-like protein; Region: YwpF; pfam14183 1399115008799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1399115008800 catalytic core [active] 1399115008801 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1399115008802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1399115008803 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1399115008804 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1399115008805 intersubunit interface [polypeptide binding]; other site 1399115008806 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1399115008807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115008808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115008809 active site 1399115008810 catalytic tetrad [active] 1399115008811 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1399115008812 amino acid carrier protein; Region: agcS; TIGR00835 1399115008813 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1399115008814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115008815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115008816 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115008817 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1399115008818 active site residue [active] 1399115008819 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 1399115008820 CPxP motif; other site 1399115008821 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1399115008822 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1399115008823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115008824 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1399115008825 NAD(P) binding site [chemical binding]; other site 1399115008826 active site 1399115008827 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1399115008828 Sulfatase; Region: Sulfatase; cl17466 1399115008829 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1399115008830 Ligand binding site; other site 1399115008831 Putative Catalytic site; other site 1399115008832 DXD motif; other site 1399115008833 Iron permease FTR1 family; Region: FTR1; cl00475 1399115008834 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1399115008835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1399115008836 Coenzyme A binding pocket [chemical binding]; other site 1399115008837 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1399115008838 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115008839 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1399115008840 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1399115008841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115008842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115008843 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115008844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1399115008845 active site 1399115008846 metal binding site [ion binding]; metal-binding site 1399115008847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115008848 oxidoreductase; Provisional; Region: PRK07985 1399115008849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115008850 NAD(P) binding site [chemical binding]; other site 1399115008851 active site 1399115008852 maltose O-acetyltransferase; Provisional; Region: PRK10092 1399115008853 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1399115008854 active site 1399115008855 substrate binding site [chemical binding]; other site 1399115008856 trimer interface [polypeptide binding]; other site 1399115008857 CoA binding site [chemical binding]; other site 1399115008858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115008859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115008860 active site 1399115008861 phosphorylation site [posttranslational modification] 1399115008862 intermolecular recognition site; other site 1399115008863 dimerization interface [polypeptide binding]; other site 1399115008864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115008865 DNA binding site [nucleotide binding] 1399115008866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115008867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115008868 dimerization interface [polypeptide binding]; other site 1399115008869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008870 dimer interface [polypeptide binding]; other site 1399115008871 phosphorylation site [posttranslational modification] 1399115008872 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1399115008873 ATP binding site [chemical binding]; other site 1399115008874 Mg2+ binding site [ion binding]; other site 1399115008875 G-X-G motif; other site 1399115008876 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1399115008877 Peptidase family M50; Region: Peptidase_M50; pfam02163 1399115008878 active site 1399115008879 putative substrate binding region [chemical binding]; other site 1399115008880 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1399115008881 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1399115008882 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1399115008883 active site 1399115008884 catalytic site [active] 1399115008885 substrate binding site [chemical binding]; other site 1399115008886 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1399115008887 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1399115008888 putative active site [active] 1399115008889 putative FMN binding site [chemical binding]; other site 1399115008890 putative substrate binding site [chemical binding]; other site 1399115008891 putative catalytic residue [active] 1399115008892 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1399115008893 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1399115008894 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1399115008895 YycC-like protein; Region: YycC; pfam14174 1399115008896 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1399115008897 active site 1399115008898 pullulanase, type I; Region: pulA_typeI; TIGR02104 1399115008899 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1399115008900 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1399115008901 Ca binding site [ion binding]; other site 1399115008902 active site 1399115008903 catalytic site [active] 1399115008904 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1399115008905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1399115008906 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1399115008907 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1399115008908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1399115008909 NAD(P) binding site [chemical binding]; other site 1399115008910 active site 1399115008911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1399115008912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1399115008913 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1399115008914 putative dimerization interface [polypeptide binding]; other site 1399115008915 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1399115008916 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1399115008917 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1399115008918 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1399115008919 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1399115008920 active site 1399115008921 HIGH motif; other site 1399115008922 KMSK motif region; other site 1399115008923 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1399115008924 tRNA binding surface [nucleotide binding]; other site 1399115008925 anticodon binding site; other site 1399115008926 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1399115008927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1399115008928 metal binding site [ion binding]; metal-binding site 1399115008929 active site 1399115008930 I-site; other site 1399115008931 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1399115008932 Putative esterase; Region: Esterase; pfam00756 1399115008933 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1399115008934 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1399115008935 active site residue [active] 1399115008936 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1399115008937 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1399115008938 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1399115008939 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1399115008940 Na binding site [ion binding]; other site 1399115008941 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1399115008942 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1399115008943 amino acid carrier protein; Region: agcS; TIGR00835 1399115008944 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1399115008945 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1399115008946 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1399115008947 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1399115008948 hexamer interface [polypeptide binding]; other site 1399115008949 ligand binding site [chemical binding]; other site 1399115008950 putative active site [active] 1399115008951 NAD(P) binding site [chemical binding]; other site 1399115008952 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1399115008953 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1399115008954 Restriction endonuclease; Region: Mrr_cat; pfam04471 1399115008955 PAS domain; Region: PAS_9; pfam13426 1399115008956 PAS domain S-box; Region: sensory_box; TIGR00229 1399115008957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1399115008958 putative active site [active] 1399115008959 heme pocket [chemical binding]; other site 1399115008960 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1399115008961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008962 dimer interface [polypeptide binding]; other site 1399115008963 phosphorylation site [posttranslational modification] 1399115008964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008965 ATP binding site [chemical binding]; other site 1399115008966 Mg2+ binding site [ion binding]; other site 1399115008967 G-X-G motif; other site 1399115008968 thioester reductase domain; Region: Thioester-redct; TIGR01746 1399115008969 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1399115008970 putative NAD(P) binding site [chemical binding]; other site 1399115008971 active site 1399115008972 putative substrate binding site [chemical binding]; other site 1399115008973 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1399115008974 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1399115008975 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1399115008976 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1399115008977 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1399115008978 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1399115008979 ligand binding site [chemical binding]; other site 1399115008980 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1399115008981 mercuric reductase; Validated; Region: PRK06370 1399115008982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115008983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1399115008984 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1399115008985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115008986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115008987 dimerization interface [polypeptide binding]; other site 1399115008988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115008989 dimer interface [polypeptide binding]; other site 1399115008990 phosphorylation site [posttranslational modification] 1399115008991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115008992 ATP binding site [chemical binding]; other site 1399115008993 Mg2+ binding site [ion binding]; other site 1399115008994 G-X-G motif; other site 1399115008995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115008996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115008997 active site 1399115008998 phosphorylation site [posttranslational modification] 1399115008999 intermolecular recognition site; other site 1399115009000 dimerization interface [polypeptide binding]; other site 1399115009001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115009002 DNA binding site [nucleotide binding] 1399115009003 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1399115009004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1399115009005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115009006 motif II; other site 1399115009007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1399115009008 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1399115009009 ligand binding site [chemical binding]; other site 1399115009010 active site 1399115009011 UGI interface [polypeptide binding]; other site 1399115009012 catalytic site [active] 1399115009013 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1399115009014 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1399115009015 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1399115009016 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1399115009017 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115009018 MarR family; Region: MarR; pfam01047 1399115009019 MarR family; Region: MarR_2; cl17246 1399115009020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1399115009021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1399115009022 DNA binding site [nucleotide binding] 1399115009023 domain linker motif; other site 1399115009024 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1399115009025 putative dimerization interface [polypeptide binding]; other site 1399115009026 putative ligand binding site [chemical binding]; other site 1399115009027 Bacterial SH3 domain; Region: SH3_3; pfam08239 1399115009028 NlpC/P60 family; Region: NLPC_P60; pfam00877 1399115009029 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1399115009030 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1399115009031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1399115009032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1399115009033 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1399115009034 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1399115009035 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1399115009036 FOG: CBS domain [General function prediction only]; Region: COG0517 1399115009037 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1399115009038 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1399115009039 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1399115009040 dimer interface [polypeptide binding]; other site 1399115009041 substrate binding site [chemical binding]; other site 1399115009042 ATP binding site [chemical binding]; other site 1399115009043 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1399115009044 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1399115009045 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1399115009046 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1399115009047 Ligand Binding Site [chemical binding]; other site 1399115009048 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1399115009049 active site 1399115009050 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1399115009051 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1399115009052 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1399115009053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1399115009054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1399115009055 non-specific DNA binding site [nucleotide binding]; other site 1399115009056 salt bridge; other site 1399115009057 sequence-specific DNA binding site [nucleotide binding]; other site 1399115009058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115009059 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1399115009060 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115009061 active site turn [active] 1399115009062 phosphorylation site [posttranslational modification] 1399115009063 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1399115009064 putative catalytic site [active] 1399115009065 putative metal binding site [ion binding]; other site 1399115009066 putative phosphate binding site [ion binding]; other site 1399115009067 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1399115009068 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1399115009069 active site turn [active] 1399115009070 phosphorylation site [posttranslational modification] 1399115009071 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1399115009072 CAT RNA binding domain; Region: CAT_RBD; smart01061 1399115009073 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1399115009074 PRD domain; Region: PRD; pfam00874 1399115009075 PRD domain; Region: PRD; pfam00874 1399115009076 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1399115009077 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1399115009078 putative substrate binding site [chemical binding]; other site 1399115009079 putative ATP binding site [chemical binding]; other site 1399115009080 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1399115009081 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1399115009082 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1399115009083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115009084 putative substrate translocation pore; other site 1399115009085 POT family; Region: PTR2; pfam00854 1399115009086 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1399115009087 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1399115009088 NAD binding site [chemical binding]; other site 1399115009089 active site 1399115009090 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1399115009091 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1399115009092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115009093 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115009094 ABC transporter; Region: ABC_tran_2; pfam12848 1399115009095 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115009096 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1399115009097 ApbE family; Region: ApbE; pfam02424 1399115009098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115009099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115009100 active site 1399115009101 phosphorylation site [posttranslational modification] 1399115009102 intermolecular recognition site; other site 1399115009103 dimerization interface [polypeptide binding]; other site 1399115009104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115009105 DNA binding site [nucleotide binding] 1399115009106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1399115009107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115009108 dimer interface [polypeptide binding]; other site 1399115009109 phosphorylation site [posttranslational modification] 1399115009110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115009111 ATP binding site [chemical binding]; other site 1399115009112 Mg2+ binding site [ion binding]; other site 1399115009113 G-X-G motif; other site 1399115009114 helicase 45; Provisional; Region: PTZ00424 1399115009115 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1399115009116 ATP binding site [chemical binding]; other site 1399115009117 Mg++ binding site [ion binding]; other site 1399115009118 motif III; other site 1399115009119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115009120 nucleotide binding region [chemical binding]; other site 1399115009121 ATP-binding site [chemical binding]; other site 1399115009122 integral membrane protein; Region: integ_memb_HG; TIGR03954 1399115009123 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1399115009124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115009125 Zn binding site [ion binding]; other site 1399115009126 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1399115009127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1399115009128 Zn binding site [ion binding]; other site 1399115009129 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115009130 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1399115009131 DNA-binding site [nucleotide binding]; DNA binding site 1399115009132 RNA-binding motif; other site 1399115009133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1399115009134 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1399115009135 HAMP domain; Region: HAMP; pfam00672 1399115009136 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1399115009137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115009138 Zn2+ binding site [ion binding]; other site 1399115009139 Mg2+ binding site [ion binding]; other site 1399115009140 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1399115009141 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1399115009142 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1399115009143 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1399115009144 active site 1399115009145 Zn binding site [ion binding]; other site 1399115009146 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1399115009147 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1399115009148 NADP binding site [chemical binding]; other site 1399115009149 dimer interface [polypeptide binding]; other site 1399115009150 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1399115009151 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1399115009152 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1399115009153 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1399115009154 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 1399115009155 Predicted membrane protein [Function unknown]; Region: COG1288 1399115009156 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1399115009157 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1399115009158 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1399115009159 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115009160 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115009161 active site 1399115009162 catalytic tetrad [active] 1399115009163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1399115009164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1399115009165 active site 1399115009166 catalytic tetrad [active] 1399115009167 OsmC-like protein; Region: OsmC; cl00767 1399115009168 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1399115009169 PLD-like domain; Region: PLDc_2; pfam13091 1399115009170 putative homodimer interface [polypeptide binding]; other site 1399115009171 putative active site [active] 1399115009172 catalytic site [active] 1399115009173 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1399115009174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1399115009175 ATP binding site [chemical binding]; other site 1399115009176 putative Mg++ binding site [ion binding]; other site 1399115009177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115009178 nucleotide binding region [chemical binding]; other site 1399115009179 ATP-binding site [chemical binding]; other site 1399115009180 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1399115009181 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1399115009182 active site 1399115009183 8-oxo-dGMP binding site [chemical binding]; other site 1399115009184 nudix motif; other site 1399115009185 metal binding site [ion binding]; metal-binding site 1399115009186 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1399115009187 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1399115009188 putative RNA binding site [nucleotide binding]; other site 1399115009189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115009190 S-adenosylmethionine binding site [chemical binding]; other site 1399115009191 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1399115009192 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1399115009193 putative NAD(P) binding site [chemical binding]; other site 1399115009194 peptidase T; Region: peptidase-T; TIGR01882 1399115009195 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1399115009196 metal binding site [ion binding]; metal-binding site 1399115009197 dimer interface [polypeptide binding]; other site 1399115009198 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1399115009199 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1399115009200 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1399115009201 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1399115009202 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1399115009203 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1399115009204 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1399115009205 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115009206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115009207 ABC transporter; Region: ABC_tran_2; pfam12848 1399115009208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1399115009209 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1399115009210 nudix motif; other site 1399115009211 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1399115009212 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1399115009213 hydrophobic ligand binding site; other site 1399115009214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1399115009215 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1399115009216 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1399115009217 active site 1399115009218 dimer interface [polypeptide binding]; other site 1399115009219 non-prolyl cis peptide bond; other site 1399115009220 insertion regions; other site 1399115009221 Protein of unknown function (DUF975); Region: DUF975; cl10504 1399115009222 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1399115009223 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1399115009224 Predicted membrane protein [Function unknown]; Region: COG2364 1399115009225 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1399115009226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1399115009227 putative DNA binding site [nucleotide binding]; other site 1399115009228 putative Zn2+ binding site [ion binding]; other site 1399115009229 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1399115009230 dimer interface [polypeptide binding]; other site 1399115009231 FMN binding site [chemical binding]; other site 1399115009232 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1399115009233 dimer interface [polypeptide binding]; other site 1399115009234 FMN binding site [chemical binding]; other site 1399115009235 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1399115009236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1399115009237 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1399115009238 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1399115009239 ATP binding site [chemical binding]; other site 1399115009240 Mg++ binding site [ion binding]; other site 1399115009241 motif III; other site 1399115009242 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1399115009243 nucleotide binding region [chemical binding]; other site 1399115009244 ATP-binding site [chemical binding]; other site 1399115009245 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1399115009246 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1399115009247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1399115009248 FeS/SAM binding site; other site 1399115009249 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1399115009250 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1399115009251 Walker A/P-loop; other site 1399115009252 ATP binding site [chemical binding]; other site 1399115009253 Q-loop/lid; other site 1399115009254 ABC transporter signature motif; other site 1399115009255 Walker B; other site 1399115009256 D-loop; other site 1399115009257 H-loop/switch region; other site 1399115009258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115009259 S-adenosylmethionine binding site [chemical binding]; other site 1399115009260 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315 1399115009261 heat shock protein 90; Provisional; Region: PRK05218 1399115009262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115009263 ATP binding site [chemical binding]; other site 1399115009264 Mg2+ binding site [ion binding]; other site 1399115009265 G-X-G motif; other site 1399115009266 short chain dehydrogenase; Validated; Region: PRK08589 1399115009267 classical (c) SDRs; Region: SDR_c; cd05233 1399115009268 NAD(P) binding site [chemical binding]; other site 1399115009269 active site 1399115009270 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1399115009271 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1399115009272 metal binding site [ion binding]; metal-binding site 1399115009273 dimer interface [polypeptide binding]; other site 1399115009274 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1399115009275 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1399115009276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115009277 putative substrate translocation pore; other site 1399115009278 FOG: CBS domain [General function prediction only]; Region: COG0517 1399115009279 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 1399115009280 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1399115009281 MarR family; Region: MarR; pfam01047 1399115009282 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1399115009283 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1399115009284 S-methylmethionine transporter; Provisional; Region: PRK11387 1399115009285 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1399115009286 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1399115009287 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1399115009288 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1399115009289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115009290 DNA-binding site [nucleotide binding]; DNA binding site 1399115009291 FCD domain; Region: FCD; pfam07729 1399115009292 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1399115009293 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1399115009294 N- and C-terminal domain interface [polypeptide binding]; other site 1399115009295 active site 1399115009296 catalytic site [active] 1399115009297 metal binding site [ion binding]; metal-binding site 1399115009298 carbohydrate binding site [chemical binding]; other site 1399115009299 ATP binding site [chemical binding]; other site 1399115009300 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1399115009301 gluconate transporter; Region: gntP; TIGR00791 1399115009302 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1399115009303 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1399115009304 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1399115009305 peroxiredoxin; Region: AhpC; TIGR03137 1399115009306 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1399115009307 dimer interface [polypeptide binding]; other site 1399115009308 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1399115009309 catalytic triad [active] 1399115009310 peroxidatic and resolving cysteines [active] 1399115009311 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1399115009312 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1399115009313 catalytic residue [active] 1399115009314 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1399115009315 catalytic residues [active] 1399115009316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1399115009317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1399115009318 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1399115009319 malate:quinone oxidoreductase; Validated; Region: PRK05257 1399115009320 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1399115009321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1399115009322 active site 1399115009323 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1399115009324 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1399115009325 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1399115009326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1399115009327 catalytic core [active] 1399115009328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1399115009329 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1399115009330 putative substrate translocation pore; other site 1399115009331 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 1399115009332 nudix motif; other site 1399115009333 Tubby C 2; Region: Tub_2; cl02043 1399115009334 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1399115009335 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1399115009336 FMN binding site [chemical binding]; other site 1399115009337 active site 1399115009338 catalytic residues [active] 1399115009339 substrate binding site [chemical binding]; other site 1399115009340 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1399115009341 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1399115009342 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1399115009343 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1399115009344 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1399115009345 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1399115009346 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1399115009347 substrate binding pocket [chemical binding]; other site 1399115009348 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1399115009349 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 1399115009350 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1399115009351 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1399115009352 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1399115009353 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1399115009354 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1399115009355 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1399115009356 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1399115009357 protein binding site [polypeptide binding]; other site 1399115009358 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1399115009359 YycH protein; Region: YycI; pfam09648 1399115009360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1399115009361 YycH protein; Region: YycH; pfam07435 1399115009362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1399115009363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1399115009364 dimerization interface [polypeptide binding]; other site 1399115009365 PAS domain; Region: PAS; smart00091 1399115009366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1399115009367 dimer interface [polypeptide binding]; other site 1399115009368 phosphorylation site [posttranslational modification] 1399115009369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115009370 ATP binding site [chemical binding]; other site 1399115009371 Mg2+ binding site [ion binding]; other site 1399115009372 G-X-G motif; other site 1399115009373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1399115009374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1399115009375 active site 1399115009376 phosphorylation site [posttranslational modification] 1399115009377 intermolecular recognition site; other site 1399115009378 dimerization interface [polypeptide binding]; other site 1399115009379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1399115009380 DNA binding site [nucleotide binding] 1399115009381 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1399115009382 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1399115009383 GDP-binding site [chemical binding]; other site 1399115009384 ACT binding site; other site 1399115009385 IMP binding site; other site 1399115009386 replicative DNA helicase; Provisional; Region: PRK05748 1399115009387 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1399115009388 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1399115009389 Walker A motif; other site 1399115009390 ATP binding site [chemical binding]; other site 1399115009391 Walker B motif; other site 1399115009392 DNA binding loops [nucleotide binding] 1399115009393 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1399115009394 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1399115009395 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1399115009396 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1399115009397 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1399115009398 DHH family; Region: DHH; pfam01368 1399115009399 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1399115009400 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1399115009401 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1399115009402 dimer interface [polypeptide binding]; other site 1399115009403 ssDNA binding site [nucleotide binding]; other site 1399115009404 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1399115009405 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1399115009406 GTP-binding protein YchF; Reviewed; Region: PRK09601 1399115009407 YchF GTPase; Region: YchF; cd01900 1399115009408 G1 box; other site 1399115009409 GTP/Mg2+ binding site [chemical binding]; other site 1399115009410 Switch I region; other site 1399115009411 G2 box; other site 1399115009412 Switch II region; other site 1399115009413 G3 box; other site 1399115009414 G4 box; other site 1399115009415 G5 box; other site 1399115009416 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1399115009417 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1399115009418 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1399115009419 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1399115009420 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1399115009421 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1399115009422 ParB-like nuclease domain; Region: ParB; smart00470 1399115009423 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1399115009424 ParB-like nuclease domain; Region: ParB; smart00470 1399115009425 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1399115009426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1399115009427 S-adenosylmethionine binding site [chemical binding]; other site 1399115009428 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1399115009429 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1399115009430 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1399115009431 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1399115009432 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1399115009433 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1399115009434 G1 box; other site 1399115009435 GTP/Mg2+ binding site [chemical binding]; other site 1399115009436 Switch I region; other site 1399115009437 G2 box; other site 1399115009438 Switch II region; other site 1399115009439 G3 box; other site 1399115009440 G4 box; other site 1399115009441 G5 box; other site 1399115009442 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1399115009443 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1399115009444 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1399115009445 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1399115009446 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1399115009447 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1399115009448 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1399115009449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115009450 Walker A motif; other site 1399115009451 ATP binding site [chemical binding]; other site 1399115009452 Walker B motif; other site 1399115009453 arginine finger; other site 1399115009454 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1399115009455 DnaA box-binding interface [nucleotide binding]; other site 1399115009456 DNA polymerase III subunit beta; Validated; Region: PRK05643 1399115009457 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1399115009458 putative DNA binding surface [nucleotide binding]; other site 1399115009459 dimer interface [polypeptide binding]; other site 1399115009460 beta-clamp/clamp loader binding surface; other site 1399115009461 beta-clamp/translesion DNA polymerase binding surface; other site 1399115009462 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1399115009463 recombination protein F; Reviewed; Region: recF; PRK00064 1399115009464 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1399115009465 Walker A/P-loop; other site 1399115009466 ATP binding site [chemical binding]; other site 1399115009467 Q-loop/lid; other site 1399115009468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1399115009469 ABC transporter signature motif; other site 1399115009470 Walker B; other site 1399115009471 D-loop; other site 1399115009472 H-loop/switch region; other site 1399115009473 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1399115009474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1399115009475 Mg2+ binding site [ion binding]; other site 1399115009476 G-X-G motif; other site 1399115009477 Pleckstrin homology-like domain; Region: PH-like; cl17171 1399115009478 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1399115009479 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1399115009480 anchoring element; other site 1399115009481 dimer interface [polypeptide binding]; other site 1399115009482 ATP binding site [chemical binding]; other site 1399115009483 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1399115009484 active site 1399115009485 putative metal-binding site [ion binding]; other site 1399115009486 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1399115009487 DNA gyrase subunit A; Validated; Region: PRK05560 1399115009488 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1399115009489 CAP-like domain; other site 1399115009490 active site 1399115009491 primary dimer interface [polypeptide binding]; other site 1399115009492 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115009493 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115009494 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115009495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115009496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1399115009497 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1399115009498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1399115009499 Zn2+ binding site [ion binding]; other site 1399115009500 Mg2+ binding site [ion binding]; other site 1399115009501 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1399115009502 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1399115009503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1399115009504 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1399115009505 active site 1399115009506 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1399115009507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1399115009508 DNA-binding site [nucleotide binding]; DNA binding site 1399115009509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1399115009510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1399115009511 homodimer interface [polypeptide binding]; other site 1399115009512 catalytic residue [active] 1399115009513 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 1399115009514 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1399115009515 phosphate binding site [ion binding]; other site 1399115009516 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1399115009517 predicted active site [active] 1399115009518 catalytic triad [active] 1399115009519 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1399115009520 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1399115009521 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1399115009522 T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch. 1399115009523 seryl-tRNA synthetase; Provisional; Region: PRK05431 1399115009524 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1399115009525 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1399115009526 dimer interface [polypeptide binding]; other site 1399115009527 active site 1399115009528 motif 1; other site 1399115009529 motif 2; other site 1399115009530 motif 3; other site 1399115009531 DinB superfamily; Region: DinB_2; pfam12867 1399115009532 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1399115009533 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1399115009534 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1399115009535 Substrate-binding site [chemical binding]; other site 1399115009536 Substrate specificity [chemical binding]; other site 1399115009537 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1399115009538 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1399115009539 Substrate-binding site [chemical binding]; other site 1399115009540 Substrate specificity [chemical binding]; other site 1399115009541 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1399115009542 nucleoside/Zn binding site; other site 1399115009543 dimer interface [polypeptide binding]; other site 1399115009544 catalytic motif [active] 1399115009545 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1399115009546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1399115009547 Walker A motif; other site 1399115009548 ATP binding site [chemical binding]; other site 1399115009549 Walker B motif; other site 1399115009550 arginine finger; other site 1399115009551 hypothetical protein; Validated; Region: PRK00153 1399115009552 recombination protein RecR; Reviewed; Region: recR; PRK00076 1399115009553 RecR protein; Region: RecR; pfam02132 1399115009554 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1399115009555 putative active site [active] 1399115009556 putative metal-binding site [ion binding]; other site 1399115009557 tetramer interface [polypeptide binding]; other site 1399115009558 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704