-- dump date 20140619_092351 -- class Genbank::misc_feature -- table misc_feature_note -- id note 262543000001 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 262543000002 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 262543000003 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 262543000004 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 262543000005 DnaA N-terminal domain; Region: DnaA_N; pfam11638 262543000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543000007 Walker A motif; other site 262543000008 ATP binding site [chemical binding]; other site 262543000009 Walker B motif; other site 262543000010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 262543000011 arginine finger; other site 262543000012 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 262543000013 DnaA box-binding interface [nucleotide binding]; other site 262543000014 DNA polymerase III subunit beta; Validated; Region: PRK05643 262543000015 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 262543000016 putative DNA binding surface [nucleotide binding]; other site 262543000017 dimer interface [polypeptide binding]; other site 262543000018 beta-clamp/clamp loader binding surface; other site 262543000019 beta-clamp/translesion DNA polymerase binding surface; other site 262543000020 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 262543000021 recombination protein F; Reviewed; Region: recF; PRK00064 262543000022 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 262543000023 Walker A/P-loop; other site 262543000024 ATP binding site [chemical binding]; other site 262543000025 Q-loop/lid; other site 262543000026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543000027 ABC transporter signature motif; other site 262543000028 Walker B; other site 262543000029 D-loop; other site 262543000030 H-loop/switch region; other site 262543000031 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 262543000032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543000033 Mg2+ binding site [ion binding]; other site 262543000034 G-X-G motif; other site 262543000035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 262543000036 anchoring element; other site 262543000037 dimer interface [polypeptide binding]; other site 262543000038 ATP binding site [chemical binding]; other site 262543000039 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 262543000040 active site 262543000041 putative metal-binding site [ion binding]; other site 262543000042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 262543000043 DNA gyrase subunit A; Validated; Region: PRK05560 262543000044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 262543000045 CAP-like domain; other site 262543000046 active site 262543000047 primary dimer interface [polypeptide binding]; other site 262543000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543000053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543000054 Zn2+ binding site [ion binding]; other site 262543000055 Mg2+ binding site [ion binding]; other site 262543000056 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 262543000057 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262543000058 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 262543000059 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 262543000060 active site 262543000061 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 262543000062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543000063 DNA-binding site [nucleotide binding]; DNA binding site 262543000064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262543000065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543000066 homodimer interface [polypeptide binding]; other site 262543000067 catalytic residue [active] 262543000068 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 262543000069 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 262543000070 phosphate binding site [ion binding]; other site 262543000071 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 262543000072 predicted active site [active] 262543000073 catalytic triad [active] 262543000074 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 262543000075 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 262543000076 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 262543000077 seryl-tRNA synthetase; Provisional; Region: PRK05431 262543000078 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 262543000079 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 262543000080 dimer interface [polypeptide binding]; other site 262543000081 active site 262543000082 motif 1; other site 262543000083 motif 2; other site 262543000084 motif 3; other site 262543000085 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 262543000086 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 262543000087 Substrate-binding site [chemical binding]; other site 262543000088 Substrate specificity [chemical binding]; other site 262543000089 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 262543000090 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 262543000091 Substrate-binding site [chemical binding]; other site 262543000092 Substrate specificity [chemical binding]; other site 262543000093 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 262543000094 nucleoside/Zn binding site; other site 262543000095 dimer interface [polypeptide binding]; other site 262543000096 catalytic motif [active] 262543000097 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 262543000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543000099 Walker A motif; other site 262543000100 ATP binding site [chemical binding]; other site 262543000101 Walker B motif; other site 262543000102 arginine finger; other site 262543000103 hypothetical protein; Validated; Region: PRK00153 262543000104 recombination protein RecR; Reviewed; Region: recR; PRK00076 262543000105 RecR protein; Region: RecR; pfam02132 262543000106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 262543000107 putative active site [active] 262543000108 putative metal-binding site [ion binding]; other site 262543000109 tetramer interface [polypeptide binding]; other site 262543000110 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 262543000111 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262543000112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543000113 catalytic residue [active] 262543000114 thymidylate kinase; Validated; Region: tmk; PRK00698 262543000115 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 262543000116 TMP-binding site; other site 262543000117 ATP-binding site [chemical binding]; other site 262543000118 Protein of unknown function (DUF970); Region: DUF970; pfam06153 262543000119 DNA polymerase III subunit delta'; Validated; Region: PRK08058 262543000120 DNA polymerase III subunit delta'; Validated; Region: PRK08485 262543000121 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 262543000122 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 262543000123 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262543000124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543000125 S-adenosylmethionine binding site [chemical binding]; other site 262543000126 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 262543000127 GIY-YIG motif/motif A; other site 262543000128 putative active site [active] 262543000129 putative metal binding site [ion binding]; other site 262543000130 Predicted methyltransferases [General function prediction only]; Region: COG0313 262543000131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 262543000132 putative SAM binding site [chemical binding]; other site 262543000133 putative homodimer interface [polypeptide binding]; other site 262543000134 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 262543000135 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262543000136 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 262543000137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 262543000138 active site 262543000139 HIGH motif; other site 262543000140 KMSKS motif; other site 262543000141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 262543000142 tRNA binding surface [nucleotide binding]; other site 262543000143 anticodon binding site; other site 262543000144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 262543000145 dimer interface [polypeptide binding]; other site 262543000146 putative tRNA-binding site [nucleotide binding]; other site 262543000147 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 262543000148 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 262543000149 active site 262543000150 Domain of unknown function (DUF348); Region: DUF348; pfam03990 262543000151 Domain of unknown function (DUF348); Region: DUF348; pfam03990 262543000152 Domain of unknown function (DUF348); Region: DUF348; pfam03990 262543000153 G5 domain; Region: G5; pfam07501 262543000154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 262543000155 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 262543000156 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 262543000157 putative active site [active] 262543000158 putative metal binding site [ion binding]; other site 262543000159 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 262543000160 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 262543000161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543000162 S-adenosylmethionine binding site [chemical binding]; other site 262543000163 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 262543000164 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 262543000165 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 262543000166 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 262543000167 pur operon repressor; Provisional; Region: PRK09213 262543000168 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 262543000169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543000170 active site 262543000171 regulatory protein SpoVG; Reviewed; Region: PRK13259 262543000172 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 262543000173 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 262543000174 Substrate binding site; other site 262543000175 Mg++ binding site; other site 262543000176 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 262543000177 active site 262543000178 substrate binding site [chemical binding]; other site 262543000179 CoA binding site [chemical binding]; other site 262543000180 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 262543000181 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 262543000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543000183 active site 262543000184 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 262543000185 putative active site [active] 262543000186 catalytic residue [active] 262543000187 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 262543000188 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 262543000189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543000190 ATP binding site [chemical binding]; other site 262543000191 putative Mg++ binding site [ion binding]; other site 262543000192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543000193 nucleotide binding region [chemical binding]; other site 262543000194 ATP-binding site [chemical binding]; other site 262543000195 TRCF domain; Region: TRCF; pfam03461 262543000196 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 262543000197 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 262543000198 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 262543000199 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 262543000200 putative SAM binding site [chemical binding]; other site 262543000201 putative homodimer interface [polypeptide binding]; other site 262543000202 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 262543000203 homodimer interface [polypeptide binding]; other site 262543000204 metal binding site [ion binding]; metal-binding site 262543000205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 262543000206 homodimer interface [polypeptide binding]; other site 262543000207 active site 262543000208 putative chemical substrate binding site [chemical binding]; other site 262543000209 metal binding site [ion binding]; metal-binding site 262543000210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543000211 RNA binding surface [nucleotide binding]; other site 262543000212 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 262543000213 Septum formation initiator; Region: DivIC; pfam04977 262543000214 hypothetical protein; Provisional; Region: PRK08582 262543000215 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 262543000216 RNA binding site [nucleotide binding]; other site 262543000217 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 262543000218 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 262543000219 Ligand Binding Site [chemical binding]; other site 262543000220 TilS substrate C-terminal domain; Region: TilS_C; smart00977 262543000221 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543000222 active site 262543000223 FtsH Extracellular; Region: FtsH_ext; pfam06480 262543000224 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 262543000225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543000226 Walker A motif; other site 262543000227 ATP binding site [chemical binding]; other site 262543000228 Walker B motif; other site 262543000229 arginine finger; other site 262543000230 Peptidase family M41; Region: Peptidase_M41; pfam01434 262543000231 pantothenate kinase; Reviewed; Region: PRK13318 262543000232 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 262543000233 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 262543000234 dimerization interface [polypeptide binding]; other site 262543000235 domain crossover interface; other site 262543000236 redox-dependent activation switch; other site 262543000237 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 262543000238 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 262543000239 dimer interface [polypeptide binding]; other site 262543000240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543000241 catalytic residue [active] 262543000242 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 262543000243 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 262543000244 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 262543000245 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 262543000246 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 262543000247 glutamine binding [chemical binding]; other site 262543000248 catalytic triad [active] 262543000249 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 262543000250 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 262543000251 homodimer interface [polypeptide binding]; other site 262543000252 substrate-cofactor binding pocket; other site 262543000253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543000254 catalytic residue [active] 262543000255 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 262543000256 dihydropteroate synthase; Region: DHPS; TIGR01496 262543000257 substrate binding pocket [chemical binding]; other site 262543000258 dimer interface [polypeptide binding]; other site 262543000259 inhibitor binding site; inhibition site 262543000260 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 262543000261 homooctamer interface [polypeptide binding]; other site 262543000262 active site 262543000263 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 262543000264 catalytic center binding site [active] 262543000265 ATP binding site [chemical binding]; other site 262543000266 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 262543000267 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 262543000268 FMN binding site [chemical binding]; other site 262543000269 active site 262543000270 catalytic residues [active] 262543000271 substrate binding site [chemical binding]; other site 262543000272 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 262543000273 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 262543000274 dimer interface [polypeptide binding]; other site 262543000275 putative anticodon binding site; other site 262543000276 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 262543000277 motif 1; other site 262543000278 active site 262543000279 motif 2; other site 262543000280 motif 3; other site 262543000281 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 262543000282 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 262543000283 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 262543000284 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 262543000285 ADP binding site [chemical binding]; other site 262543000286 phosphagen binding site; other site 262543000287 substrate specificity loop; other site 262543000288 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 262543000289 Clp amino terminal domain; Region: Clp_N; pfam02861 262543000290 Clp amino terminal domain; Region: Clp_N; pfam02861 262543000291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543000292 Walker A motif; other site 262543000293 ATP binding site [chemical binding]; other site 262543000294 Walker B motif; other site 262543000295 arginine finger; other site 262543000296 UvrB/uvrC motif; Region: UVR; pfam02151 262543000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543000298 Walker A motif; other site 262543000299 ATP binding site [chemical binding]; other site 262543000300 Walker B motif; other site 262543000301 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 262543000302 DNA repair protein RadA; Provisional; Region: PRK11823 262543000303 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 262543000304 Walker A motif/ATP binding site; other site 262543000305 ATP binding site [chemical binding]; other site 262543000306 Walker B motif; other site 262543000307 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 262543000308 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 262543000309 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 262543000310 putative active site [active] 262543000311 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 262543000312 substrate binding site; other site 262543000313 dimer interface; other site 262543000314 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 262543000315 homotrimer interaction site [polypeptide binding]; other site 262543000316 zinc binding site [ion binding]; other site 262543000317 CDP-binding sites; other site 262543000318 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 262543000319 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 262543000320 HIGH motif; other site 262543000321 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 262543000322 active site 262543000323 KMSKS motif; other site 262543000324 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 262543000325 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 262543000326 trimer interface [polypeptide binding]; other site 262543000327 active site 262543000328 substrate binding site [chemical binding]; other site 262543000329 CoA binding site [chemical binding]; other site 262543000330 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 262543000331 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 262543000332 active site 262543000333 HIGH motif; other site 262543000334 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 262543000335 KMSKS motif; other site 262543000336 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262543000337 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 262543000338 active site 262543000339 metal binding site [ion binding]; metal-binding site 262543000340 dimerization interface [polypeptide binding]; other site 262543000341 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 262543000342 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 262543000343 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262543000344 YacP-like NYN domain; Region: NYN_YacP; pfam05991 262543000345 RNA polymerase factor sigma-70; Validated; Region: PRK08295 262543000346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543000347 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 262543000348 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 262543000349 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 262543000350 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 262543000351 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 262543000352 putative homodimer interface [polypeptide binding]; other site 262543000353 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 262543000354 heterodimer interface [polypeptide binding]; other site 262543000355 homodimer interface [polypeptide binding]; other site 262543000356 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 262543000357 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 262543000358 23S rRNA interface [nucleotide binding]; other site 262543000359 L7/L12 interface [polypeptide binding]; other site 262543000360 putative thiostrepton binding site; other site 262543000361 L25 interface [polypeptide binding]; other site 262543000362 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 262543000363 mRNA/rRNA interface [nucleotide binding]; other site 262543000364 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 262543000365 23S rRNA interface [nucleotide binding]; other site 262543000366 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 262543000367 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 262543000368 peripheral dimer interface [polypeptide binding]; other site 262543000369 core dimer interface [polypeptide binding]; other site 262543000370 L10 interface [polypeptide binding]; other site 262543000371 L11 interface [polypeptide binding]; other site 262543000372 putative EF-Tu interaction site [polypeptide binding]; other site 262543000373 putative EF-G interaction site [polypeptide binding]; other site 262543000374 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 262543000375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543000376 S-adenosylmethionine binding site [chemical binding]; other site 262543000377 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 262543000378 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 262543000379 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 262543000380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262543000381 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262543000382 RPB10 interaction site [polypeptide binding]; other site 262543000383 RPB1 interaction site [polypeptide binding]; other site 262543000384 RPB11 interaction site [polypeptide binding]; other site 262543000385 RPB3 interaction site [polypeptide binding]; other site 262543000386 RPB12 interaction site [polypeptide binding]; other site 262543000387 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 262543000388 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 262543000389 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 262543000390 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 262543000391 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 262543000392 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 262543000393 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 262543000394 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 262543000395 G-loop; other site 262543000396 DNA binding site [nucleotide binding] 262543000397 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 262543000398 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 262543000399 S17 interaction site [polypeptide binding]; other site 262543000400 S8 interaction site; other site 262543000401 16S rRNA interaction site [nucleotide binding]; other site 262543000402 streptomycin interaction site [chemical binding]; other site 262543000403 23S rRNA interaction site [nucleotide binding]; other site 262543000404 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 262543000405 30S ribosomal protein S7; Validated; Region: PRK05302 262543000406 elongation factor G; Reviewed; Region: PRK00007 262543000407 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 262543000408 G1 box; other site 262543000409 putative GEF interaction site [polypeptide binding]; other site 262543000410 GTP/Mg2+ binding site [chemical binding]; other site 262543000411 Switch I region; other site 262543000412 G2 box; other site 262543000413 G3 box; other site 262543000414 Switch II region; other site 262543000415 G4 box; other site 262543000416 G5 box; other site 262543000417 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 262543000418 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 262543000419 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 262543000420 elongation factor Tu; Reviewed; Region: PRK00049 262543000421 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 262543000422 G1 box; other site 262543000423 GEF interaction site [polypeptide binding]; other site 262543000424 GTP/Mg2+ binding site [chemical binding]; other site 262543000425 Switch I region; other site 262543000426 G2 box; other site 262543000427 G3 box; other site 262543000428 Switch II region; other site 262543000429 G4 box; other site 262543000430 G5 box; other site 262543000431 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 262543000432 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 262543000433 Antibiotic Binding Site [chemical binding]; other site 262543000434 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 262543000435 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 262543000436 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 262543000437 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 262543000438 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 262543000439 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 262543000440 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 262543000441 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 262543000442 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 262543000443 putative translocon binding site; other site 262543000444 protein-rRNA interface [nucleotide binding]; other site 262543000445 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 262543000446 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 262543000447 G-X-X-G motif; other site 262543000448 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 262543000449 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 262543000450 23S rRNA interface [nucleotide binding]; other site 262543000451 5S rRNA interface [nucleotide binding]; other site 262543000452 putative antibiotic binding site [chemical binding]; other site 262543000453 L25 interface [polypeptide binding]; other site 262543000454 L27 interface [polypeptide binding]; other site 262543000455 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 262543000456 23S rRNA interface [nucleotide binding]; other site 262543000457 putative translocon interaction site; other site 262543000458 signal recognition particle (SRP54) interaction site; other site 262543000459 L23 interface [polypeptide binding]; other site 262543000460 trigger factor interaction site; other site 262543000461 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 262543000462 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 262543000463 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 262543000464 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 262543000465 RNA binding site [nucleotide binding]; other site 262543000466 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 262543000467 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 262543000468 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 262543000469 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 262543000470 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 262543000471 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 262543000472 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262543000473 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262543000474 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 262543000475 5S rRNA interface [nucleotide binding]; other site 262543000476 L27 interface [polypeptide binding]; other site 262543000477 23S rRNA interface [nucleotide binding]; other site 262543000478 L5 interface [polypeptide binding]; other site 262543000479 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 262543000480 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 262543000481 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 262543000482 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 262543000483 23S rRNA binding site [nucleotide binding]; other site 262543000484 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 262543000485 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 262543000486 SecY translocase; Region: SecY; pfam00344 262543000487 adenylate kinase; Reviewed; Region: adk; PRK00279 262543000488 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 262543000489 AMP-binding site [chemical binding]; other site 262543000490 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 262543000491 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262543000492 active site 262543000493 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 262543000494 rRNA binding site [nucleotide binding]; other site 262543000495 predicted 30S ribosome binding site; other site 262543000496 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 262543000497 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 262543000498 30S ribosomal protein S13; Region: bact_S13; TIGR03631 262543000499 30S ribosomal protein S11; Validated; Region: PRK05309 262543000500 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 262543000501 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 262543000502 alphaNTD - beta interaction site [polypeptide binding]; other site 262543000503 alphaNTD homodimer interface [polypeptide binding]; other site 262543000504 alphaNTD - beta' interaction site [polypeptide binding]; other site 262543000505 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 262543000506 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 262543000507 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 262543000508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262543000509 Walker A/P-loop; other site 262543000510 ATP binding site [chemical binding]; other site 262543000511 Q-loop/lid; other site 262543000512 ABC transporter signature motif; other site 262543000513 Walker B; other site 262543000514 D-loop; other site 262543000515 H-loop/switch region; other site 262543000516 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 262543000517 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262543000518 Walker A/P-loop; other site 262543000519 ATP binding site [chemical binding]; other site 262543000520 Q-loop/lid; other site 262543000521 ABC transporter signature motif; other site 262543000522 Walker B; other site 262543000523 D-loop; other site 262543000524 H-loop/switch region; other site 262543000525 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 262543000526 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 262543000527 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 262543000528 dimerization interface 3.5A [polypeptide binding]; other site 262543000529 active site 262543000530 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 262543000531 23S rRNA interface [nucleotide binding]; other site 262543000532 L3 interface [polypeptide binding]; other site 262543000533 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 262543000534 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 262543000535 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262543000536 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 262543000537 Domain of unknown function DUF59; Region: DUF59; pfam01883 262543000538 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 262543000539 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 262543000540 Walker A motif; other site 262543000541 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 262543000542 Arginase family; Region: Arginase; cd09989 262543000543 agmatinase; Region: agmatinase; TIGR01230 262543000544 active site 262543000545 Mn binding site [ion binding]; other site 262543000546 oligomer interface [polypeptide binding]; other site 262543000547 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 262543000548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543000549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543000550 DNA binding residues [nucleotide binding] 262543000551 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 262543000552 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 262543000553 Uncharacterized conserved protein [Function unknown]; Region: COG1624 262543000554 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 262543000555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 262543000556 YbbR-like protein; Region: YbbR; pfam07949 262543000557 YbbR-like protein; Region: YbbR; pfam07949 262543000558 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 262543000559 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 262543000560 active site 262543000561 substrate binding site [chemical binding]; other site 262543000562 metal binding site [ion binding]; metal-binding site 262543000563 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 262543000564 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 262543000565 glutaminase active site [active] 262543000566 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 262543000567 dimer interface [polypeptide binding]; other site 262543000568 active site 262543000569 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 262543000570 dimer interface [polypeptide binding]; other site 262543000571 active site 262543000572 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 262543000573 putative NAD(P) binding site [chemical binding]; other site 262543000574 homodimer interface [polypeptide binding]; other site 262543000575 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 262543000576 Isochorismatase family; Region: Isochorismatase; pfam00857 262543000577 catalytic triad [active] 262543000578 conserved cis-peptide bond; other site 262543000579 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 262543000580 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 262543000581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 262543000582 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 262543000583 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 262543000584 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 262543000585 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 262543000586 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 262543000587 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 262543000588 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 262543000589 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 262543000590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543000591 Predicted transcriptional regulators [Transcription]; Region: COG1733 262543000592 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 262543000593 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262543000594 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 262543000595 NADP binding site [chemical binding]; other site 262543000596 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 262543000597 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 262543000598 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 262543000599 PhnA protein; Region: PhnA; pfam03831 262543000600 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543000601 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262543000602 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262543000603 ligand binding site [chemical binding]; other site 262543000604 flexible hinge region; other site 262543000605 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 262543000606 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543000607 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 262543000608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543000609 active site 262543000610 motif I; other site 262543000611 motif II; other site 262543000612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543000613 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543000614 Coenzyme A binding pocket [chemical binding]; other site 262543000615 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 262543000616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543000617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543000618 DNA binding residues [nucleotide binding] 262543000619 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 262543000620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543000621 Coenzyme A binding pocket [chemical binding]; other site 262543000622 Dynamin family; Region: Dynamin_N; pfam00350 262543000623 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 262543000624 G1 box; other site 262543000625 GTP/Mg2+ binding site [chemical binding]; other site 262543000626 Switch I region; other site 262543000627 G2 box; other site 262543000628 Switch II region; other site 262543000629 G3 box; other site 262543000630 G4 box; other site 262543000631 G5 box; other site 262543000632 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 262543000633 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543000634 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262543000635 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543000636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543000637 dimer interface [polypeptide binding]; other site 262543000638 putative CheW interface [polypeptide binding]; other site 262543000639 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 262543000640 Predicted metalloprotease [General function prediction only]; Region: COG2321 262543000641 SnoaL-like domain; Region: SnoaL_2; pfam12680 262543000642 Rrf2 family protein; Region: rrf2_super; TIGR00738 262543000643 Transcriptional regulator; Region: Rrf2; pfam02082 262543000644 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543000645 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 262543000646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543000647 Walker A/P-loop; other site 262543000648 ATP binding site [chemical binding]; other site 262543000649 Q-loop/lid; other site 262543000650 ABC transporter signature motif; other site 262543000651 Walker B; other site 262543000652 D-loop; other site 262543000653 H-loop/switch region; other site 262543000654 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 262543000655 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543000656 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 262543000657 Walker A/P-loop; other site 262543000658 ATP binding site [chemical binding]; other site 262543000659 Q-loop/lid; other site 262543000660 ABC transporter signature motif; other site 262543000661 Walker B; other site 262543000662 D-loop; other site 262543000663 H-loop/switch region; other site 262543000664 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262543000665 Putative cyclase; Region: Cyclase; cl00814 262543000666 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 262543000667 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 262543000668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262543000669 kynureninase; Region: kynureninase; TIGR01814 262543000670 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543000671 catalytic residue [active] 262543000672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262543000673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543000674 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 262543000675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543000676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543000677 putative substrate translocation pore; other site 262543000678 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 262543000679 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262543000680 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543000681 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543000682 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 262543000683 substrate binding site; other site 262543000684 dimer interface; other site 262543000685 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 262543000686 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262543000687 putative NAD(P) binding site [chemical binding]; other site 262543000688 putative catalytic Zn binding site [ion binding]; other site 262543000689 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543000690 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543000691 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 262543000692 putative FMN binding site [chemical binding]; other site 262543000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543000694 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262543000695 putative substrate translocation pore; other site 262543000696 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 262543000697 HlyD family secretion protein; Region: HlyD_3; pfam13437 262543000698 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 262543000699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543000700 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 262543000701 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543000702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543000703 metal binding site [ion binding]; metal-binding site 262543000704 active site 262543000705 I-site; other site 262543000706 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543000707 MarR family; Region: MarR; pfam01047 262543000708 lysine transporter; Provisional; Region: PRK10836 262543000709 methionine sulfoxide reductase A; Provisional; Region: PRK14054 262543000710 methionine sulfoxide reductase B; Provisional; Region: PRK00222 262543000711 SelR domain; Region: SelR; pfam01641 262543000712 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 262543000713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 262543000714 amino acid transporter; Region: 2A0306; TIGR00909 262543000715 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 262543000716 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 262543000717 putative oxidoreductase; Provisional; Region: PRK11579 262543000718 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262543000719 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 262543000720 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 262543000721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543000722 NAD(P) binding site [chemical binding]; other site 262543000723 active site 262543000724 Staphylococcal nuclease homologues; Region: SNc; smart00318 262543000725 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 262543000726 Catalytic site; other site 262543000727 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 262543000728 Cation efflux family; Region: Cation_efflux; pfam01545 262543000729 glucose-1-dehydrogenase; Provisional; Region: PRK08936 262543000730 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 262543000731 NAD binding site [chemical binding]; other site 262543000732 homodimer interface [polypeptide binding]; other site 262543000733 active site 262543000734 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 262543000735 ABC1 family; Region: ABC1; cl17513 262543000736 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 262543000737 Predicted membrane protein [Function unknown]; Region: COG2860 262543000738 UPF0126 domain; Region: UPF0126; pfam03458 262543000739 UPF0126 domain; Region: UPF0126; pfam03458 262543000740 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 262543000741 putative heme peroxidase; Provisional; Region: PRK12276 262543000742 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 262543000743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543000744 active site 262543000745 xanthine permease; Region: pbuX; TIGR03173 262543000746 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 262543000747 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543000748 active site residue [active] 262543000749 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 262543000750 Cache domain; Region: Cache_1; pfam02743 262543000751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543000752 dimerization interface [polypeptide binding]; other site 262543000753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543000754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543000755 dimer interface [polypeptide binding]; other site 262543000756 putative CheW interface [polypeptide binding]; other site 262543000757 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 262543000758 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 262543000759 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 262543000760 Carbon starvation protein CstA; Region: CstA; pfam02554 262543000761 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 262543000762 two-component response regulator; Provisional; Region: PRK14084 262543000763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543000764 active site 262543000765 phosphorylation site [posttranslational modification] 262543000766 intermolecular recognition site; other site 262543000767 dimerization interface [polypeptide binding]; other site 262543000768 LytTr DNA-binding domain; Region: LytTR; smart00850 262543000769 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 262543000770 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 262543000771 GAF domain; Region: GAF; cl17456 262543000772 Histidine kinase; Region: His_kinase; pfam06580 262543000773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543000774 ATP binding site [chemical binding]; other site 262543000775 Mg2+ binding site [ion binding]; other site 262543000776 G-X-G motif; other site 262543000777 putative GTP cyclohydrolase; Provisional; Region: PRK13674 262543000778 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 262543000779 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 262543000780 HD domain; Region: HD_3; pfam13023 262543000781 HD domain; Region: HD_3; cl17350 262543000782 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 262543000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543000784 putative substrate translocation pore; other site 262543000785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 262543000786 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 262543000787 EDD domain protein, DegV family; Region: DegV; TIGR00762 262543000788 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 262543000789 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 262543000790 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 262543000791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543000792 Zn2+ binding site [ion binding]; other site 262543000793 Mg2+ binding site [ion binding]; other site 262543000794 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262543000795 Phosphotransferase enzyme family; Region: APH; pfam01636 262543000796 active site 262543000797 ATP binding site [chemical binding]; other site 262543000798 substrate binding site [chemical binding]; other site 262543000799 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 262543000800 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 262543000801 Nucleoside recognition; Region: Gate; pfam07670 262543000802 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 262543000803 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 262543000804 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262543000805 NAD binding site [chemical binding]; other site 262543000806 substrate binding site [chemical binding]; other site 262543000807 putative active site [active] 262543000808 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 262543000809 active site 1 [active] 262543000810 dimer interface [polypeptide binding]; other site 262543000811 hexamer interface [polypeptide binding]; other site 262543000812 active site 2 [active] 262543000813 YwhD family; Region: YwhD; pfam08741 262543000814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 262543000815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 262543000816 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 262543000817 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 262543000818 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262543000819 putative active site [active] 262543000820 putative metal binding site [ion binding]; other site 262543000821 BCCT family transporter; Region: BCCT; pfam02028 262543000822 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 262543000823 dimer interface [polypeptide binding]; other site 262543000824 FMN binding site [chemical binding]; other site 262543000825 spermidine synthase; Provisional; Region: PRK00811 262543000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543000827 agmatinase; Region: agmatinase; TIGR01230 262543000828 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 262543000829 putative active site [active] 262543000830 Mn binding site [ion binding]; other site 262543000831 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 262543000832 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 262543000833 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 262543000834 active site 262543000835 putative catalytic site [active] 262543000836 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 262543000837 heme-binding site [chemical binding]; other site 262543000838 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543000839 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543000840 dimer interface [polypeptide binding]; other site 262543000841 putative CheW interface [polypeptide binding]; other site 262543000842 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543000843 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543000844 Integrase core domain; Region: rve; pfam00665 262543000845 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262543000846 metal-binding site [ion binding] 262543000847 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262543000848 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262543000849 metal-binding site [ion binding] 262543000850 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262543000851 Soluble P-type ATPase [General function prediction only]; Region: COG4087 262543000852 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262543000853 putative homodimer interface [polypeptide binding]; other site 262543000854 putative homotetramer interface [polypeptide binding]; other site 262543000855 putative allosteric switch controlling residues; other site 262543000856 putative metal binding site [ion binding]; other site 262543000857 putative homodimer-homodimer interface [polypeptide binding]; other site 262543000858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543000859 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262543000860 putative substrate translocation pore; other site 262543000861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543000862 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 262543000863 acetolactate synthase; Reviewed; Region: PRK08322 262543000864 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262543000865 PYR/PP interface [polypeptide binding]; other site 262543000866 dimer interface [polypeptide binding]; other site 262543000867 TPP binding site [chemical binding]; other site 262543000868 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262543000869 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 262543000870 TPP-binding site [chemical binding]; other site 262543000871 succinic semialdehyde dehydrogenase; Region: PLN02278 262543000872 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 262543000873 tetramerization interface [polypeptide binding]; other site 262543000874 NAD(P) binding site [chemical binding]; other site 262543000875 catalytic residues [active] 262543000876 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 262543000877 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 262543000878 Ca binding site [ion binding]; other site 262543000879 active site 262543000880 catalytic site [active] 262543000881 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 262543000882 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 262543000883 nudix motif; other site 262543000884 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262543000885 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543000886 NAD(P) binding site [chemical binding]; other site 262543000887 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 262543000888 4Fe-4S binding domain; Region: Fer4; cl02805 262543000889 Cysteine-rich domain; Region: CCG; pfam02754 262543000890 Cysteine-rich domain; Region: CCG; pfam02754 262543000891 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 262543000892 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 262543000893 DNA binding residues [nucleotide binding] 262543000894 putative dimer interface [polypeptide binding]; other site 262543000895 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262543000896 Domain of unknown function DUF21; Region: DUF21; pfam01595 262543000897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262543000898 Transporter associated domain; Region: CorC_HlyC; smart01091 262543000899 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 262543000900 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 262543000901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543000902 ATP binding site [chemical binding]; other site 262543000903 Mg2+ binding site [ion binding]; other site 262543000904 G-X-G motif; other site 262543000905 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 262543000906 active site 262543000907 catalytic residues [active] 262543000908 EDD domain protein, DegV family; Region: DegV; TIGR00762 262543000909 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 262543000910 CrcB-like protein; Region: CRCB; cl09114 262543000911 CrcB-like protein; Region: CRCB; cl09114 262543000912 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543000913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543000914 dimer interface [polypeptide binding]; other site 262543000915 putative CheW interface [polypeptide binding]; other site 262543000916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543000917 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 262543000918 putative NAD(P) binding site [chemical binding]; other site 262543000919 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 262543000920 active site 262543000921 NTP binding site [chemical binding]; other site 262543000922 metal binding triad [ion binding]; metal-binding site 262543000923 antibiotic binding site [chemical binding]; other site 262543000924 Predicted transcriptional regulators [Transcription]; Region: COG1733 262543000925 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 262543000926 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 262543000927 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 262543000928 putative metal binding site [ion binding]; other site 262543000929 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262543000930 active site 262543000931 NIPSNAP; Region: NIPSNAP; pfam07978 262543000932 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 262543000933 nudix motif; other site 262543000934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262543000935 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543000936 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 262543000937 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 262543000938 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 262543000939 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 262543000940 YtkA-like; Region: YtkA; pfam13115 262543000941 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262543000942 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 262543000943 catalytic triad [active] 262543000944 catalytic triad [active] 262543000945 oxyanion hole [active] 262543000946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262543000947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543000948 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 262543000949 ATP binding site [chemical binding]; other site 262543000950 Mg2+ binding site [ion binding]; other site 262543000951 G-X-G motif; other site 262543000952 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 262543000953 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 262543000954 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 262543000955 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 262543000956 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262543000957 DNA binding site [nucleotide binding] 262543000958 active site 262543000959 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 262543000960 AAA domain; Region: AAA_18; pfam13238 262543000961 AAA domain; Region: AAA_17; pfam13207 262543000962 NUMOD4 motif; Region: NUMOD4; pfam07463 262543000963 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 262543000964 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543000965 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543000966 metal binding site [ion binding]; metal-binding site 262543000967 active site 262543000968 I-site; other site 262543000969 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 262543000970 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 262543000971 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 262543000972 nudix motif; other site 262543000973 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 262543000974 catalytic triad [active] 262543000975 active site nucleophile [active] 262543000976 Predicted transcriptional regulators [Transcription]; Region: COG1695 262543000977 Transcriptional regulator PadR-like family; Region: PadR; cl17335 262543000978 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 262543000979 homotrimer interaction site [polypeptide binding]; other site 262543000980 putative active site [active] 262543000981 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 262543000982 metal binding site [ion binding]; metal-binding site 262543000983 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 262543000984 PLD-like domain; Region: PLDc_2; pfam13091 262543000985 putative homodimer interface [polypeptide binding]; other site 262543000986 putative active site [active] 262543000987 catalytic site [active] 262543000988 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262543000989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543000990 ATP binding site [chemical binding]; other site 262543000991 putative Mg++ binding site [ion binding]; other site 262543000992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543000993 nucleotide binding region [chemical binding]; other site 262543000994 ATP-binding site [chemical binding]; other site 262543000995 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 262543000996 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 262543000997 Methyltransferase domain; Region: Methyltransf_26; pfam13659 262543000998 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 262543000999 TIGR02687 family protein; Region: TIGR02687 262543001000 PglZ domain; Region: PglZ; pfam08665 262543001001 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 262543001002 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 262543001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543001004 AAA domain; Region: AAA_23; pfam13476 262543001005 Walker A/P-loop; other site 262543001006 ATP binding site [chemical binding]; other site 262543001007 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 262543001008 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262543001009 active site 262543001010 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 262543001011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543001012 dimer interface [polypeptide binding]; other site 262543001013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262543001014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262543001015 DNA binding site [nucleotide binding] 262543001016 domain linker motif; other site 262543001017 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 262543001018 dimerization interface [polypeptide binding]; other site 262543001019 ligand binding site [chemical binding]; other site 262543001020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543001021 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543001022 Probable transposase; Region: OrfB_IS605; pfam01385 262543001023 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543001024 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 262543001025 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 262543001026 Peptidase family M28; Region: Peptidase_M28; pfam04389 262543001027 metal binding site [ion binding]; metal-binding site 262543001028 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 262543001029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543001030 TPR repeat; Region: TPR_11; pfam13414 262543001031 TPR motif; other site 262543001032 binding surface 262543001033 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543001034 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543001035 Integrase core domain; Region: rve; pfam00665 262543001036 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 262543001037 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262543001038 catalytic residues [active] 262543001039 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 262543001040 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 262543001041 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 262543001042 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543001043 MarR family; Region: MarR_2; pfam12802 262543001044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262543001045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543001046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543001047 Walker A/P-loop; other site 262543001048 ATP binding site [chemical binding]; other site 262543001049 Q-loop/lid; other site 262543001050 ABC transporter signature motif; other site 262543001051 Walker B; other site 262543001052 D-loop; other site 262543001053 H-loop/switch region; other site 262543001054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262543001055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543001056 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 262543001057 Walker A/P-loop; other site 262543001058 ATP binding site [chemical binding]; other site 262543001059 Q-loop/lid; other site 262543001060 ABC transporter signature motif; other site 262543001061 Walker B; other site 262543001062 D-loop; other site 262543001063 H-loop/switch region; other site 262543001064 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543001065 active site residue [active] 262543001066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262543001067 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543001068 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543001069 active site residue [active] 262543001070 Conserved TM helix; Region: TM_helix; pfam05552 262543001071 Conserved TM helix; Region: TM_helix; pfam05552 262543001072 Conserved TM helix; Region: TM_helix; pfam05552 262543001073 amino acid transporter; Region: 2A0306; TIGR00909 262543001074 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 262543001075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543001076 Coenzyme A binding pocket [chemical binding]; other site 262543001077 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 262543001078 nudix motif; other site 262543001079 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 262543001080 active site 262543001081 dimer interface [polypeptide binding]; other site 262543001082 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 262543001083 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 262543001084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543001085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543001086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262543001087 dimerization interface [polypeptide binding]; other site 262543001088 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 262543001089 putative homodimer interface [polypeptide binding]; other site 262543001090 putative homotetramer interface [polypeptide binding]; other site 262543001091 putative metal binding site [ion binding]; other site 262543001092 putative homodimer-homodimer interface [polypeptide binding]; other site 262543001093 putative allosteric switch controlling residues; other site 262543001094 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 262543001095 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543001096 active site residue [active] 262543001097 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543001098 active site residue [active] 262543001099 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 262543001100 CPxP motif; other site 262543001101 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543001102 active site residue [active] 262543001103 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 262543001104 active site residue [active] 262543001105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543001106 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 262543001107 CPxP motif; other site 262543001108 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 262543001109 Domain of unknown function DUF302; Region: DUF302; cl01364 262543001110 methionine sulfoxide reductase A; Provisional; Region: PRK14054 262543001111 methionine sulfoxide reductase B; Provisional; Region: PRK00222 262543001112 SelR domain; Region: SelR; pfam01641 262543001113 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 262543001114 active site 262543001115 catalytic triad [active] 262543001116 GAF domain; Region: GAF_3; pfam13492 262543001117 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 262543001118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543001119 dimer interface [polypeptide binding]; other site 262543001120 phosphorylation site [posttranslational modification] 262543001121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543001122 ATP binding site [chemical binding]; other site 262543001123 Mg2+ binding site [ion binding]; other site 262543001124 G-X-G motif; other site 262543001125 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543001126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543001127 metal binding site [ion binding]; metal-binding site 262543001128 active site 262543001129 I-site; other site 262543001130 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 262543001131 Heat induced stress protein YflT; Region: YflT; pfam11181 262543001132 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262543001133 Ligand Binding Site [chemical binding]; other site 262543001134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543001135 MarR family; Region: MarR_2; pfam12802 262543001136 Transport protein; Region: actII; TIGR00833 262543001137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543001138 Transcriptional regulators [Transcription]; Region: MarR; COG1846 262543001139 MarR family; Region: MarR_2; pfam12802 262543001140 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262543001141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 262543001142 nucleotide binding site [chemical binding]; other site 262543001143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 262543001144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262543001145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543001146 dimer interface [polypeptide binding]; other site 262543001147 conserved gate region; other site 262543001148 putative PBP binding loops; other site 262543001149 ABC-ATPase subunit interface; other site 262543001150 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262543001151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543001152 dimer interface [polypeptide binding]; other site 262543001153 conserved gate region; other site 262543001154 putative PBP binding loops; other site 262543001155 ABC-ATPase subunit interface; other site 262543001156 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 262543001157 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 262543001158 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 262543001159 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 262543001160 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 262543001161 Melibiase; Region: Melibiase; pfam02065 262543001162 galactokinase; Provisional; Region: PRK05322 262543001163 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 262543001164 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 262543001165 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 262543001166 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 262543001167 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 262543001168 NAD binding site [chemical binding]; other site 262543001169 homodimer interface [polypeptide binding]; other site 262543001170 active site 262543001171 substrate binding site [chemical binding]; other site 262543001172 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 262543001173 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 262543001174 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 262543001175 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 262543001176 active site 262543001177 catalytic residues [active] 262543001178 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 262543001179 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 262543001180 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262543001181 DNA binding site [nucleotide binding] 262543001182 active site 262543001183 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 262543001184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543001185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543001186 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543001187 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 262543001188 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262543001189 E3 interaction surface; other site 262543001190 lipoyl attachment site [posttranslational modification]; other site 262543001191 e3 binding domain; Region: E3_binding; pfam02817 262543001192 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262543001193 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262543001194 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262543001195 alpha subunit interface [polypeptide binding]; other site 262543001196 TPP binding site [chemical binding]; other site 262543001197 heterodimer interface [polypeptide binding]; other site 262543001198 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262543001199 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 262543001200 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262543001201 TPP-binding site [chemical binding]; other site 262543001202 tetramer interface [polypeptide binding]; other site 262543001203 heterodimer interface [polypeptide binding]; other site 262543001204 phosphorylation loop region [posttranslational modification] 262543001205 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 262543001206 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 262543001207 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 262543001208 NAD binding site [chemical binding]; other site 262543001209 Phe binding site; other site 262543001210 Predicted thioesterase [General function prediction only]; Region: COG5496 262543001211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262543001212 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 262543001213 acyl-activating enzyme (AAE) consensus motif; other site 262543001214 AMP binding site [chemical binding]; other site 262543001215 active site 262543001216 CoA binding site [chemical binding]; other site 262543001217 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 262543001218 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 262543001219 Phenylacetic acid degradation B; Region: PaaB; cl01371 262543001220 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 262543001221 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 262543001222 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 262543001223 conserved hypothetical protein; Region: TIGR02118 262543001224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262543001225 enoyl-CoA hydratase; Provisional; Region: PRK05862 262543001226 substrate binding site [chemical binding]; other site 262543001227 oxyanion hole (OAH) forming residues; other site 262543001228 trimer interface [polypeptide binding]; other site 262543001229 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262543001230 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262543001231 NAD(P) binding site [chemical binding]; other site 262543001232 catalytic residues [active] 262543001233 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 262543001234 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262543001235 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262543001236 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 262543001237 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262543001238 dimer interface [polypeptide binding]; other site 262543001239 active site 262543001240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262543001241 enoyl-CoA hydratase; Provisional; Region: PRK07657 262543001242 substrate binding site [chemical binding]; other site 262543001243 oxyanion hole (OAH) forming residues; other site 262543001244 trimer interface [polypeptide binding]; other site 262543001245 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 262543001246 PaaX-like protein; Region: PaaX; pfam07848 262543001247 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 262543001248 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 262543001249 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 262543001250 trimer interface [polypeptide binding]; other site 262543001251 putative metal binding site [ion binding]; other site 262543001252 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 262543001253 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262543001254 FMN binding site [chemical binding]; other site 262543001255 substrate binding site [chemical binding]; other site 262543001256 putative catalytic residue [active] 262543001257 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543001258 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543001259 methionine sulfoxide reductase A; Provisional; Region: PRK14054 262543001260 Uncharacterized conserved protein [Function unknown]; Region: COG1359 262543001261 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262543001262 NlpC/P60 family; Region: NLPC_P60; pfam00877 262543001263 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543001264 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262543001265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543001266 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 262543001267 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 262543001268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543001269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543001270 active site 262543001271 catalytic tetrad [active] 262543001272 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 262543001273 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 262543001274 putative active site [active] 262543001275 metal binding site [ion binding]; metal-binding site 262543001276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543001277 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 262543001278 Repair protein; Region: Repair_PSII; pfam04536 262543001279 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 262543001280 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 262543001281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262543001282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262543001283 metal-binding site [ion binding] 262543001284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262543001285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 262543001286 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 262543001287 YolD-like protein; Region: YolD; pfam08863 262543001288 DNA polymerase IV; Reviewed; Region: PRK03103 262543001289 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 262543001290 active site 262543001291 DNA binding site [nucleotide binding] 262543001292 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 262543001293 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 262543001294 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 262543001295 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262543001296 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 262543001297 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 262543001298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543001299 Coenzyme A binding pocket [chemical binding]; other site 262543001300 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 262543001301 Cupin domain; Region: Cupin_2; pfam07883 262543001302 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 262543001303 intersubunit interface [polypeptide binding]; other site 262543001304 active site 262543001305 Zn2+ binding site [ion binding]; other site 262543001306 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 262543001307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543001308 motif II; other site 262543001309 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 262543001310 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 262543001311 dimer interface [polypeptide binding]; other site 262543001312 active site 262543001313 catalytic residue [active] 262543001314 metal binding site [ion binding]; metal-binding site 262543001315 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 262543001316 Phosphotransferase enzyme family; Region: APH; pfam01636 262543001317 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 262543001318 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 262543001319 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 262543001320 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 262543001321 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 262543001322 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 262543001323 Walker A/P-loop; other site 262543001324 ATP binding site [chemical binding]; other site 262543001325 Q-loop/lid; other site 262543001326 ABC transporter signature motif; other site 262543001327 Walker B; other site 262543001328 D-loop; other site 262543001329 H-loop/switch region; other site 262543001330 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 262543001331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262543001332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 262543001333 TM-ABC transporter signature motif; other site 262543001334 MoxR-like ATPases [General function prediction only]; Region: COG0714 262543001335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543001336 Walker A motif; other site 262543001337 ATP binding site [chemical binding]; other site 262543001338 Walker B motif; other site 262543001339 arginine finger; other site 262543001340 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262543001341 Protein of unknown function DUF58; Region: DUF58; pfam01882 262543001342 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 262543001343 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 262543001344 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 262543001345 GMP synthase; Reviewed; Region: guaA; PRK00074 262543001346 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 262543001347 AMP/PPi binding site [chemical binding]; other site 262543001348 candidate oxyanion hole; other site 262543001349 catalytic triad [active] 262543001350 potential glutamine specificity residues [chemical binding]; other site 262543001351 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 262543001352 ATP Binding subdomain [chemical binding]; other site 262543001353 Ligand Binding sites [chemical binding]; other site 262543001354 Dimerization subdomain; other site 262543001355 Heat induced stress protein YflT; Region: YflT; pfam11181 262543001356 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 262543001357 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 262543001358 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262543001359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543001360 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543001361 Probable transposase; Region: OrfB_IS605; pfam01385 262543001362 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543001363 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 262543001364 Proline dehydrogenase; Region: Pro_dh; cl03282 262543001365 NETI protein; Region: NETI; pfam14044 262543001366 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 262543001367 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 262543001368 ATP-grasp domain; Region: ATP-grasp; pfam02222 262543001369 adenylosuccinate lyase; Provisional; Region: PRK07492 262543001370 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 262543001371 tetramer interface [polypeptide binding]; other site 262543001372 active site 262543001373 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 262543001374 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 262543001375 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 262543001376 ATP binding site [chemical binding]; other site 262543001377 active site 262543001378 substrate binding site [chemical binding]; other site 262543001379 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 262543001380 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 262543001381 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 262543001382 putative active site [active] 262543001383 catalytic triad [active] 262543001384 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 262543001385 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 262543001386 dimerization interface [polypeptide binding]; other site 262543001387 ATP binding site [chemical binding]; other site 262543001388 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 262543001389 dimerization interface [polypeptide binding]; other site 262543001390 ATP binding site [chemical binding]; other site 262543001391 amidophosphoribosyltransferase; Provisional; Region: PRK07631 262543001392 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 262543001393 active site 262543001394 tetramer interface [polypeptide binding]; other site 262543001395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543001396 active site 262543001397 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 262543001398 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 262543001399 dimerization interface [polypeptide binding]; other site 262543001400 putative ATP binding site [chemical binding]; other site 262543001401 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 262543001402 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 262543001403 active site 262543001404 substrate binding site [chemical binding]; other site 262543001405 cosubstrate binding site; other site 262543001406 catalytic site [active] 262543001407 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 262543001408 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 262543001409 purine monophosphate binding site [chemical binding]; other site 262543001410 dimer interface [polypeptide binding]; other site 262543001411 putative catalytic residues [active] 262543001412 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 262543001413 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 262543001414 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 262543001415 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 262543001416 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 262543001417 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 262543001418 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 262543001419 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262543001420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262543001421 active site 262543001422 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 262543001423 Trp repressor protein; Region: Trp_repressor; cl17266 262543001424 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 262543001425 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 262543001426 PcrB family; Region: PcrB; pfam01884 262543001427 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 262543001428 substrate binding site [chemical binding]; other site 262543001429 putative active site [active] 262543001430 dimer interface [polypeptide binding]; other site 262543001431 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 262543001432 Part of AAA domain; Region: AAA_19; pfam13245 262543001433 Family description; Region: UvrD_C_2; pfam13538 262543001434 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 262543001435 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 262543001436 nucleotide binding pocket [chemical binding]; other site 262543001437 K-X-D-G motif; other site 262543001438 catalytic site [active] 262543001439 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 262543001440 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 262543001441 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 262543001442 Dimer interface [polypeptide binding]; other site 262543001443 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 262543001444 active site 262543001445 catalytic site [active] 262543001446 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 262543001447 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 262543001448 putative dimer interface [polypeptide binding]; other site 262543001449 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 262543001450 putative dimer interface [polypeptide binding]; other site 262543001451 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 262543001452 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 262543001453 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 262543001454 putative active site [active] 262543001455 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 262543001456 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 262543001457 metal binding site [ion binding]; metal-binding site 262543001458 dimer interface [polypeptide binding]; other site 262543001459 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 262543001460 chaperone protein DnaJ; Provisional; Region: PRK14299 262543001461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 262543001462 HSP70 interaction site [polypeptide binding]; other site 262543001463 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 262543001464 dimer interface [polypeptide binding]; other site 262543001465 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 262543001466 Clp amino terminal domain; Region: Clp_N; pfam02861 262543001467 Clp amino terminal domain; Region: Clp_N; pfam02861 262543001468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543001469 Walker A motif; other site 262543001470 ATP binding site [chemical binding]; other site 262543001471 Walker B motif; other site 262543001472 arginine finger; other site 262543001473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543001474 Walker A motif; other site 262543001475 ATP binding site [chemical binding]; other site 262543001476 Walker B motif; other site 262543001477 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 262543001478 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 262543001479 glutaminase A; Region: Gln_ase; TIGR03814 262543001480 CHAD domain; Region: CHAD; pfam05235 262543001481 multidrug efflux protein; Reviewed; Region: PRK01766 262543001482 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 262543001483 cation binding site [ion binding]; other site 262543001484 Predicted integral membrane protein [Function unknown]; Region: COG0392 262543001485 Uncharacterized conserved protein [Function unknown]; Region: COG2898 262543001486 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 262543001487 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 262543001488 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 262543001489 active site 262543001490 dimer interface [polypeptide binding]; other site 262543001491 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 262543001492 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 262543001493 active site 262543001494 trimer interface [polypeptide binding]; other site 262543001495 allosteric site; other site 262543001496 active site lid [active] 262543001497 hexamer (dimer of trimers) interface [polypeptide binding]; other site 262543001498 Transcriptional regulator [Transcription]; Region: LytR; COG1316 262543001499 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262543001500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543001501 DNA-binding site [nucleotide binding]; DNA binding site 262543001502 UTRA domain; Region: UTRA; pfam07702 262543001503 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 262543001504 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 262543001505 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 262543001506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543001507 Coenzyme A binding pocket [chemical binding]; other site 262543001508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543001509 argininosuccinate synthase; Provisional; Region: PRK13820 262543001510 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 262543001511 ANP binding site [chemical binding]; other site 262543001512 Substrate Binding Site II [chemical binding]; other site 262543001513 Substrate Binding Site I [chemical binding]; other site 262543001514 argininosuccinate lyase; Provisional; Region: PRK00855 262543001515 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 262543001516 active sites [active] 262543001517 tetramer interface [polypeptide binding]; other site 262543001518 aspartate kinase; Reviewed; Region: PRK06635 262543001519 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 262543001520 putative nucleotide binding site [chemical binding]; other site 262543001521 putative catalytic residues [active] 262543001522 putative Mg ion binding site [ion binding]; other site 262543001523 putative aspartate binding site [chemical binding]; other site 262543001524 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 262543001525 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 262543001526 putative allosteric regulatory residue; other site 262543001527 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 262543001528 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 262543001529 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 262543001530 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262543001531 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 262543001532 dimer interface [polypeptide binding]; other site 262543001533 active site 262543001534 catalytic residue [active] 262543001535 dihydrodipicolinate reductase; Provisional; Region: PRK00048 262543001536 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262543001537 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 262543001538 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 262543001539 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 262543001540 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 262543001541 trimer interface [polypeptide binding]; other site 262543001542 active site 262543001543 substrate binding site [chemical binding]; other site 262543001544 CoA binding site [chemical binding]; other site 262543001545 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 262543001546 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 262543001547 homodimer interface [polypeptide binding]; other site 262543001548 substrate-cofactor binding pocket; other site 262543001549 catalytic residue [active] 262543001550 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 262543001551 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 262543001552 active site 262543001553 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262543001554 dimer interface [polypeptide binding]; other site 262543001555 substrate binding site [chemical binding]; other site 262543001556 catalytic residues [active] 262543001557 diaminopimelate decarboxylase; Region: lysA; TIGR01048 262543001558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 262543001559 active site 262543001560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262543001561 substrate binding site [chemical binding]; other site 262543001562 catalytic residues [active] 262543001563 dimer interface [polypeptide binding]; other site 262543001564 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 262543001565 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 262543001566 NodB motif; other site 262543001567 active site 262543001568 catalytic site [active] 262543001569 metal binding site [ion binding]; metal-binding site 262543001570 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 262543001571 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 262543001572 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 262543001573 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 262543001574 Walker A/P-loop; other site 262543001575 ATP binding site [chemical binding]; other site 262543001576 Q-loop/lid; other site 262543001577 ABC transporter signature motif; other site 262543001578 Walker B; other site 262543001579 D-loop; other site 262543001580 H-loop/switch region; other site 262543001581 FOG: CBS domain [General function prediction only]; Region: COG0517 262543001582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 262543001583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543001584 dimer interface [polypeptide binding]; other site 262543001585 conserved gate region; other site 262543001586 putative PBP binding loops; other site 262543001587 ABC-ATPase subunit interface; other site 262543001588 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 262543001589 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 262543001590 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 262543001591 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 262543001592 trimer interface [polypeptide binding]; other site 262543001593 putative metal binding site [ion binding]; other site 262543001594 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 262543001595 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262543001596 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 262543001597 active site 262543001598 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 262543001599 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262543001600 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 262543001601 peptide binding site [polypeptide binding]; other site 262543001602 MgtC family; Region: MgtC; pfam02308 262543001603 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 262543001604 PAS fold; Region: PAS; pfam00989 262543001605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543001606 putative active site [active] 262543001607 heme pocket [chemical binding]; other site 262543001608 PAS domain; Region: PAS_9; pfam13426 262543001609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543001610 putative active site [active] 262543001611 heme pocket [chemical binding]; other site 262543001612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543001613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543001614 metal binding site [ion binding]; metal-binding site 262543001615 active site 262543001616 I-site; other site 262543001617 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543001618 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 262543001619 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262543001620 inhibitor-cofactor binding pocket; inhibition site 262543001621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543001622 catalytic residue [active] 262543001623 CsbD-like; Region: CsbD; pfam05532 262543001624 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 262543001625 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543001626 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543001627 active site turn [active] 262543001628 phosphorylation site [posttranslational modification] 262543001629 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 262543001630 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 262543001631 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 262543001632 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 262543001633 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 262543001634 NodB motif; other site 262543001635 active site 262543001636 catalytic site [active] 262543001637 Zn binding site [ion binding]; other site 262543001638 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543001639 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543001640 Integrase core domain; Region: rve; pfam00665 262543001641 YhfH-like protein; Region: YhfH; pfam14149 262543001642 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 262543001643 dimer interface [polypeptide binding]; other site 262543001644 FMN binding site [chemical binding]; other site 262543001645 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 262543001646 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 262543001647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543001648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543001649 dimerization interface [polypeptide binding]; other site 262543001650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543001651 dimer interface [polypeptide binding]; other site 262543001652 phosphorylation site [posttranslational modification] 262543001653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543001654 ATP binding site [chemical binding]; other site 262543001655 Mg2+ binding site [ion binding]; other site 262543001656 G-X-G motif; other site 262543001657 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543001658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543001659 active site 262543001660 phosphorylation site [posttranslational modification] 262543001661 intermolecular recognition site; other site 262543001662 dimerization interface [polypeptide binding]; other site 262543001663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543001664 DNA binding site [nucleotide binding] 262543001665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262543001666 catalytic core [active] 262543001667 phytoene desaturase; Region: crtI_fam; TIGR02734 262543001668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543001669 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 262543001670 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543001671 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 262543001672 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 262543001673 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 262543001674 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 262543001675 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 262543001676 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 262543001677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262543001678 active site 262543001679 metal binding site [ion binding]; metal-binding site 262543001680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262543001681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543001682 Predicted membrane protein [Function unknown]; Region: COG1511 262543001683 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 262543001684 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 262543001685 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 262543001686 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543001687 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 262543001688 NADP binding site [chemical binding]; other site 262543001689 dimer interface [polypeptide binding]; other site 262543001690 Uncharacterized conserved protein [Function unknown]; Region: COG0759 262543001691 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 262543001692 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 262543001693 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262543001694 NAD(P) binding site [chemical binding]; other site 262543001695 catalytic residues [active] 262543001696 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 262543001697 Predicted membrane protein [Function unknown]; Region: COG4325 262543001698 Protein of unknown function (DUF456); Region: DUF456; pfam04306 262543001699 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262543001700 Domain of unknown function DUF21; Region: DUF21; pfam01595 262543001701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262543001702 Transporter associated domain; Region: CorC_HlyC; smart01091 262543001703 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 262543001704 intracellular protease, PfpI family; Region: PfpI; TIGR01382 262543001705 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 262543001706 proposed catalytic triad [active] 262543001707 conserved cys residue [active] 262543001708 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 262543001709 dimer interface [polypeptide binding]; other site 262543001710 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543001711 substrate binding site [chemical binding]; other site 262543001712 metal binding site [ion binding]; metal-binding site 262543001713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 262543001714 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543001715 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543001716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 262543001717 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 262543001718 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543001719 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543001720 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 262543001721 dimer interface [polypeptide binding]; other site 262543001722 substrate binding site [chemical binding]; other site 262543001723 ATP binding site [chemical binding]; other site 262543001724 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 262543001725 substrate binding site [chemical binding]; other site 262543001726 multimerization interface [polypeptide binding]; other site 262543001727 ATP binding site [chemical binding]; other site 262543001728 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 262543001729 thiamine phosphate binding site [chemical binding]; other site 262543001730 active site 262543001731 pyrophosphate binding site [ion binding]; other site 262543001732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543001733 dimerization interface [polypeptide binding]; other site 262543001734 putative DNA binding site [nucleotide binding]; other site 262543001735 putative Zn2+ binding site [ion binding]; other site 262543001736 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543001737 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543001738 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543001739 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 262543001740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 262543001741 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543001742 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543001743 Winged helix-turn helix; Region: HTH_29; pfam13551 262543001744 putative transposase OrfB; Reviewed; Region: PHA02517 262543001745 HTH-like domain; Region: HTH_21; pfam13276 262543001746 Integrase core domain; Region: rve; pfam00665 262543001747 Integrase core domain; Region: rve_3; pfam13683 262543001748 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 262543001749 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 262543001750 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 262543001751 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 262543001752 FAD binding domain; Region: FAD_binding_4; pfam01565 262543001753 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 262543001754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543001755 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262543001756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543001757 Coenzyme A binding pocket [chemical binding]; other site 262543001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543001759 Coenzyme A binding pocket [chemical binding]; other site 262543001760 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 262543001761 dimer interface [polypeptide binding]; other site 262543001762 FMN binding site [chemical binding]; other site 262543001763 NADPH bind site [chemical binding]; other site 262543001764 Transcriptional regulator [Transcription]; Region: LytR; COG1316 262543001765 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 262543001766 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262543001767 NAD(P) binding site [chemical binding]; other site 262543001768 putative active site [active] 262543001769 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 262543001770 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262543001771 catalytic residues [active] 262543001772 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 262543001773 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 262543001774 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 262543001775 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 262543001776 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 262543001777 heterotetramer interface [polypeptide binding]; other site 262543001778 active site pocket [active] 262543001779 cleavage site 262543001780 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 262543001781 nucleotide binding site [chemical binding]; other site 262543001782 N-acetyl-L-glutamate binding site [chemical binding]; other site 262543001783 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 262543001784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262543001785 inhibitor-cofactor binding pocket; inhibition site 262543001786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543001787 catalytic residue [active] 262543001788 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 262543001789 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 262543001790 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 262543001791 catalytic site [active] 262543001792 subunit interface [polypeptide binding]; other site 262543001793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262543001794 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 262543001795 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543001796 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 262543001797 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 262543001798 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262543001799 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 262543001800 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543001801 ornithine carbamoyltransferase; Provisional; Region: PRK00779 262543001802 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 262543001803 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 262543001804 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543001805 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 262543001806 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 262543001807 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543001808 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 262543001809 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 262543001810 Potassium binding sites [ion binding]; other site 262543001811 Cesium cation binding sites [ion binding]; other site 262543001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543001813 dimer interface [polypeptide binding]; other site 262543001814 conserved gate region; other site 262543001815 putative PBP binding loops; other site 262543001816 ABC-ATPase subunit interface; other site 262543001817 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262543001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543001819 dimer interface [polypeptide binding]; other site 262543001820 conserved gate region; other site 262543001821 putative PBP binding loops; other site 262543001822 ABC-ATPase subunit interface; other site 262543001823 asparagine synthetase AsnA; Provisional; Region: PRK05425 262543001824 motif 1; other site 262543001825 dimer interface [polypeptide binding]; other site 262543001826 active site 262543001827 motif 2; other site 262543001828 motif 3; other site 262543001829 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262543001830 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543001831 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 262543001832 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 262543001833 TrkA-C domain; Region: TrkA_C; pfam02080 262543001834 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 262543001835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262543001836 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 262543001837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543001838 dimerization interface [polypeptide binding]; other site 262543001839 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 262543001840 Histidine kinase; Region: His_kinase; pfam06580 262543001841 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 262543001842 ATP binding site [chemical binding]; other site 262543001843 G-X-G motif; other site 262543001844 Response regulator receiver domain; Region: Response_reg; pfam00072 262543001845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543001846 active site 262543001847 phosphorylation site [posttranslational modification] 262543001848 intermolecular recognition site; other site 262543001849 dimerization interface [polypeptide binding]; other site 262543001850 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 262543001851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262543001852 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 262543001853 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 262543001854 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 262543001855 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 262543001856 NAD(P) binding site [chemical binding]; other site 262543001857 catalytic residues [active] 262543001858 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543001859 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543001860 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262543001861 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 262543001862 active site 262543001863 nucleotide binding site [chemical binding]; other site 262543001864 HIGH motif; other site 262543001865 KMSKS motif; other site 262543001866 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543001867 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543001868 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262543001869 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262543001870 ligand binding site [chemical binding]; other site 262543001871 flexible hinge region; other site 262543001872 putative switch regulator; other site 262543001873 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 262543001874 non-specific DNA interactions [nucleotide binding]; other site 262543001875 DNA binding site [nucleotide binding] 262543001876 sequence specific DNA binding site [nucleotide binding]; other site 262543001877 putative cAMP binding site [chemical binding]; other site 262543001878 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 262543001879 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 262543001880 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 262543001881 Putative D-pathway homolog; other site 262543001882 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 262543001883 Low-spin heme binding site [chemical binding]; other site 262543001884 Subunit I/II interface [polypeptide binding]; other site 262543001885 Putative Q-pathway; other site 262543001886 Putative alternate electron transfer pathway; other site 262543001887 Putative water exit pathway; other site 262543001888 Binuclear center (active site) [active] 262543001889 Putative K-pathway homolog; other site 262543001890 Putative proton exit pathway; other site 262543001891 Subunit I/IIa interface [polypeptide binding]; other site 262543001892 Electron transfer pathway; other site 262543001893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262543001894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543001895 active site 262543001896 phosphorylation site [posttranslational modification] 262543001897 intermolecular recognition site; other site 262543001898 dimerization interface [polypeptide binding]; other site 262543001899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262543001900 DNA binding residues [nucleotide binding] 262543001901 dimerization interface [polypeptide binding]; other site 262543001902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262543001903 Histidine kinase; Region: HisKA_3; pfam07730 262543001904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543001905 ATP binding site [chemical binding]; other site 262543001906 Mg2+ binding site [ion binding]; other site 262543001907 G-X-G motif; other site 262543001908 Predicted membrane protein [Function unknown]; Region: COG4758 262543001909 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 262543001910 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 262543001911 GTPase RsgA; Reviewed; Region: PRK01889 262543001912 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 262543001913 RNA binding site [nucleotide binding]; other site 262543001914 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 262543001915 GTPase/Zn-binding domain interface [polypeptide binding]; other site 262543001916 GTP/Mg2+ binding site [chemical binding]; other site 262543001917 G4 box; other site 262543001918 G5 box; other site 262543001919 G1 box; other site 262543001920 Switch I region; other site 262543001921 G2 box; other site 262543001922 G3 box; other site 262543001923 Switch II region; other site 262543001924 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262543001925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543001926 Walker A/P-loop; other site 262543001927 ATP binding site [chemical binding]; other site 262543001928 Q-loop/lid; other site 262543001929 ABC transporter signature motif; other site 262543001930 Walker B; other site 262543001931 D-loop; other site 262543001932 H-loop/switch region; other site 262543001933 ABC transporter; Region: ABC_tran_2; pfam12848 262543001934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543001935 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 262543001936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543001937 FeS/SAM binding site; other site 262543001938 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 262543001939 Pyruvate formate lyase 1; Region: PFL1; cd01678 262543001940 coenzyme A binding site [chemical binding]; other site 262543001941 active site 262543001942 catalytic residues [active] 262543001943 glycine loop; other site 262543001944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 262543001945 DEAD-like helicases superfamily; Region: DEXDc; smart00487 262543001946 ATP binding site [chemical binding]; other site 262543001947 putative Mg++ binding site [ion binding]; other site 262543001948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543001949 nucleotide binding region [chemical binding]; other site 262543001950 ATP-binding site [chemical binding]; other site 262543001951 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543001952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543001953 metal binding site [ion binding]; metal-binding site 262543001954 active site 262543001955 I-site; other site 262543001956 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262543001957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543001958 Walker A/P-loop; other site 262543001959 ATP binding site [chemical binding]; other site 262543001960 ABC transporter signature motif; other site 262543001961 Walker B; other site 262543001962 D-loop; other site 262543001963 H-loop/switch region; other site 262543001964 ABC transporter; Region: ABC_tran_2; pfam12848 262543001965 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543001966 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262543001967 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262543001968 putative acyl-acceptor binding pocket; other site 262543001969 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 262543001970 S1 domain; Region: S1_2; pfam13509 262543001971 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 262543001972 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262543001973 ATP binding site [chemical binding]; other site 262543001974 Mg++ binding site [ion binding]; other site 262543001975 motif III; other site 262543001976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543001977 nucleotide binding region [chemical binding]; other site 262543001978 ATP-binding site [chemical binding]; other site 262543001979 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543001980 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 262543001981 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262543001982 active site 262543001983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 262543001984 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543001985 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543001986 Winged helix-turn helix; Region: HTH_29; pfam13551 262543001987 putative transposase OrfB; Reviewed; Region: PHA02517 262543001988 HTH-like domain; Region: HTH_21; pfam13276 262543001989 Integrase core domain; Region: rve; pfam00665 262543001990 Integrase core domain; Region: rve_3; pfam13683 262543001991 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 262543001992 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 262543001993 active site 262543001994 octamer interface [polypeptide binding]; other site 262543001995 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 262543001996 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 262543001997 acyl-activating enzyme (AAE) consensus motif; other site 262543001998 putative AMP binding site [chemical binding]; other site 262543001999 putative active site [active] 262543002000 putative CoA binding site [chemical binding]; other site 262543002001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262543002002 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 262543002003 substrate binding site [chemical binding]; other site 262543002004 oxyanion hole (OAH) forming residues; other site 262543002005 trimer interface [polypeptide binding]; other site 262543002006 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543002007 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 262543002008 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 262543002009 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 262543002010 dimer interface [polypeptide binding]; other site 262543002011 tetramer interface [polypeptide binding]; other site 262543002012 PYR/PP interface [polypeptide binding]; other site 262543002013 TPP binding site [chemical binding]; other site 262543002014 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 262543002015 TPP-binding site; other site 262543002016 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 262543002017 chorismate binding enzyme; Region: Chorismate_bind; cl10555 262543002018 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 262543002019 UbiA prenyltransferase family; Region: UbiA; pfam01040 262543002020 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 262543002021 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262543002022 substrate binding site [chemical binding]; other site 262543002023 ATP binding site [chemical binding]; other site 262543002024 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 262543002025 nudix motif; other site 262543002026 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 262543002027 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262543002028 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262543002029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543002030 motif II; other site 262543002031 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 262543002032 EamA-like transporter family; Region: EamA; pfam00892 262543002033 EamA-like transporter family; Region: EamA; pfam00892 262543002034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543002035 putative substrate translocation pore; other site 262543002036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543002037 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 262543002038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543002039 FeS/SAM binding site; other site 262543002040 YfkB-like domain; Region: YfkB; pfam08756 262543002041 TRAM domain; Region: TRAM; pfam01938 262543002042 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 262543002043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543002044 S-adenosylmethionine binding site [chemical binding]; other site 262543002045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543002046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543002047 active site 262543002048 catalytic tetrad [active] 262543002049 Uncharacterized conserved protein [Function unknown]; Region: COG0398 262543002050 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543002051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543002052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543002053 dimerization interface [polypeptide binding]; other site 262543002054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543002055 dimer interface [polypeptide binding]; other site 262543002056 phosphorylation site [posttranslational modification] 262543002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543002058 ATP binding site [chemical binding]; other site 262543002059 Mg2+ binding site [ion binding]; other site 262543002060 G-X-G motif; other site 262543002061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543002062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543002063 active site 262543002064 phosphorylation site [posttranslational modification] 262543002065 intermolecular recognition site; other site 262543002066 dimerization interface [polypeptide binding]; other site 262543002067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543002068 DNA binding site [nucleotide binding] 262543002069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543002070 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262543002071 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 262543002072 active site 262543002073 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 262543002074 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 262543002075 putative NAD(P) binding site [chemical binding]; other site 262543002076 putative active site [active] 262543002077 RecX family; Region: RecX; cl00936 262543002078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543002079 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 262543002080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543002081 Walker A/P-loop; other site 262543002082 ATP binding site [chemical binding]; other site 262543002083 Q-loop/lid; other site 262543002084 ABC transporter signature motif; other site 262543002085 Walker B; other site 262543002086 D-loop; other site 262543002087 H-loop/switch region; other site 262543002088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543002089 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 262543002090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262543002091 Walker A/P-loop; other site 262543002092 ATP binding site [chemical binding]; other site 262543002093 Q-loop/lid; other site 262543002094 ABC transporter signature motif; other site 262543002095 Walker B; other site 262543002096 D-loop; other site 262543002097 H-loop/switch region; other site 262543002098 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 262543002099 WVELL protein; Region: WVELL; pfam14043 262543002100 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 262543002101 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 262543002102 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262543002103 minor groove reading motif; other site 262543002104 helix-hairpin-helix signature motif; other site 262543002105 substrate binding pocket [chemical binding]; other site 262543002106 active site 262543002107 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 262543002108 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 262543002109 DNA binding and oxoG recognition site [nucleotide binding] 262543002110 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262543002111 hydrophobic ligand binding site; other site 262543002112 hypothetical protein; Provisional; Region: PRK13662 262543002113 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262543002114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543002115 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 262543002116 Walker A/P-loop; other site 262543002117 ATP binding site [chemical binding]; other site 262543002118 Q-loop/lid; other site 262543002119 ABC transporter signature motif; other site 262543002120 Walker B; other site 262543002121 D-loop; other site 262543002122 H-loop/switch region; other site 262543002123 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 262543002124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262543002125 inhibitor-cofactor binding pocket; inhibition site 262543002126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543002127 catalytic residue [active] 262543002128 ferric uptake regulator; Provisional; Region: fur; PRK09462 262543002129 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262543002130 metal binding site 2 [ion binding]; metal-binding site 262543002131 putative DNA binding helix; other site 262543002132 metal binding site 1 [ion binding]; metal-binding site 262543002133 dimer interface [polypeptide binding]; other site 262543002134 structural Zn2+ binding site [ion binding]; other site 262543002135 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 262543002136 epoxyqueuosine reductase; Region: TIGR00276 262543002137 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 262543002138 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 262543002139 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262543002140 DNA binding site [nucleotide binding] 262543002141 active site 262543002142 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 262543002143 Transglycosylase; Region: Transgly; pfam00912 262543002144 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 262543002145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 262543002146 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 262543002147 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 262543002148 ligand binding site; other site 262543002149 oligomer interface; other site 262543002150 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 262543002151 dimer interface [polypeptide binding]; other site 262543002152 N-terminal domain interface [polypeptide binding]; other site 262543002153 sulfate 1 binding site; other site 262543002154 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 262543002155 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 262543002156 ligand binding site; other site 262543002157 oligomer interface; other site 262543002158 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 262543002159 dimer interface [polypeptide binding]; other site 262543002160 N-terminal domain interface [polypeptide binding]; other site 262543002161 sulfate 1 binding site; other site 262543002162 glycogen synthase; Provisional; Region: glgA; PRK00654 262543002163 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 262543002164 ADP-binding pocket [chemical binding]; other site 262543002165 homodimer interface [polypeptide binding]; other site 262543002166 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 262543002167 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 262543002168 active site pocket [active] 262543002169 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262543002170 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 262543002171 active site residue [active] 262543002172 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262543002173 active site residue [active] 262543002174 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 262543002175 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 262543002176 active site 262543002177 substrate binding site [chemical binding]; other site 262543002178 metal binding site [ion binding]; metal-binding site 262543002179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543002180 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543002181 active site 262543002182 catalytic tetrad [active] 262543002183 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 262543002184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543002185 dimer interface [polypeptide binding]; other site 262543002186 conserved gate region; other site 262543002187 putative PBP binding loops; other site 262543002188 ABC-ATPase subunit interface; other site 262543002189 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262543002190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262543002191 substrate binding pocket [chemical binding]; other site 262543002192 membrane-bound complex binding site; other site 262543002193 hinge residues; other site 262543002194 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 262543002195 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 262543002196 Walker A/P-loop; other site 262543002197 ATP binding site [chemical binding]; other site 262543002198 Q-loop/lid; other site 262543002199 ABC transporter signature motif; other site 262543002200 Walker B; other site 262543002201 D-loop; other site 262543002202 H-loop/switch region; other site 262543002203 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 262543002204 active site 262543002205 homotetramer interface [polypeptide binding]; other site 262543002206 TOBE domain; Region: TOBE; pfam03459 262543002207 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 262543002208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 262543002209 hypothetical protein; Provisional; Region: PRK13676 262543002210 YhzD-like protein; Region: YhzD; pfam14120 262543002211 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262543002212 active site 262543002213 DNA polymerase IV; Validated; Region: PRK02406 262543002214 DNA binding site [nucleotide binding] 262543002215 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 262543002216 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 262543002217 oligomer interface [polypeptide binding]; other site 262543002218 Cl binding site [ion binding]; other site 262543002219 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 262543002220 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 262543002221 generic binding surface II; other site 262543002222 generic binding surface I; other site 262543002223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543002224 Zn2+ binding site [ion binding]; other site 262543002225 Mg2+ binding site [ion binding]; other site 262543002226 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 262543002227 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 262543002228 active site 262543002229 FMN binding site [chemical binding]; other site 262543002230 substrate binding site [chemical binding]; other site 262543002231 homotetramer interface [polypeptide binding]; other site 262543002232 catalytic residue [active] 262543002233 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 262543002234 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 262543002235 transcriptional regulator Hpr; Provisional; Region: PRK13777 262543002236 MarR family; Region: MarR; pfam01047 262543002237 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 262543002238 HIT family signature motif; other site 262543002239 catalytic residue [active] 262543002240 Predicted membrane protein [Function unknown]; Region: COG2261 262543002241 Predicted membrane protein [Function unknown]; Region: COG2261 262543002242 Predicted membrane protein [Function unknown]; Region: COG2261 262543002243 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262543002244 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262543002245 Walker A/P-loop; other site 262543002246 ATP binding site [chemical binding]; other site 262543002247 Q-loop/lid; other site 262543002248 ABC transporter signature motif; other site 262543002249 Walker B; other site 262543002250 D-loop; other site 262543002251 H-loop/switch region; other site 262543002252 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 262543002253 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 262543002254 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 262543002255 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262543002256 DNA binding residues [nucleotide binding] 262543002257 putative dimer interface [polypeptide binding]; other site 262543002258 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 262543002259 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 262543002260 substrate binding site [chemical binding]; other site 262543002261 active site 262543002262 ferrochelatase; Provisional; Region: PRK12435 262543002263 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 262543002264 C-terminal domain interface [polypeptide binding]; other site 262543002265 active site 262543002266 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 262543002267 active site 262543002268 N-terminal domain interface [polypeptide binding]; other site 262543002269 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 262543002270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543002271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543002272 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 262543002273 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262543002274 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 262543002275 putative active site [active] 262543002276 catalytic site [active] 262543002277 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 262543002278 putative active site [active] 262543002279 catalytic site [active] 262543002280 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262543002281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543002282 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 262543002283 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 262543002284 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 262543002285 Part of AAA domain; Region: AAA_19; pfam13245 262543002286 Family description; Region: UvrD_C_2; pfam13538 262543002287 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543002288 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262543002289 Coenzyme A binding pocket [chemical binding]; other site 262543002290 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 262543002291 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 262543002292 substrate binding [chemical binding]; other site 262543002293 active site 262543002294 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 262543002295 HAMP domain; Region: HAMP; pfam00672 262543002296 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543002297 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543002298 metal binding site [ion binding]; metal-binding site 262543002299 active site 262543002300 I-site; other site 262543002301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543002302 Coenzyme A binding pocket [chemical binding]; other site 262543002303 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262543002304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543002305 Walker A/P-loop; other site 262543002306 ATP binding site [chemical binding]; other site 262543002307 Q-loop/lid; other site 262543002308 ABC transporter signature motif; other site 262543002309 Walker B; other site 262543002310 D-loop; other site 262543002311 H-loop/switch region; other site 262543002312 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 262543002313 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 262543002314 Predicted membrane protein [Function unknown]; Region: COG2364 262543002315 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 262543002316 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 262543002317 amphipathic channel; other site 262543002318 Asn-Pro-Ala signature motifs; other site 262543002319 glycerol kinase; Provisional; Region: glpK; PRK00047 262543002320 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 262543002321 N- and C-terminal domain interface [polypeptide binding]; other site 262543002322 active site 262543002323 MgATP binding site [chemical binding]; other site 262543002324 catalytic site [active] 262543002325 metal binding site [ion binding]; metal-binding site 262543002326 glycerol binding site [chemical binding]; other site 262543002327 homotetramer interface [polypeptide binding]; other site 262543002328 homodimer interface [polypeptide binding]; other site 262543002329 FBP binding site [chemical binding]; other site 262543002330 protein IIAGlc interface [polypeptide binding]; other site 262543002331 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 262543002332 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 262543002333 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 262543002334 catalytic residues [active] 262543002335 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 262543002336 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 262543002337 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 262543002338 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 262543002339 short chain dehydrogenase; Provisional; Region: PRK06701 262543002340 NAD binding site [chemical binding]; other site 262543002341 metal binding site [ion binding]; metal-binding site 262543002342 active site 262543002343 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 262543002344 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 262543002345 acyl-activating enzyme (AAE) consensus motif; other site 262543002346 putative AMP binding site [chemical binding]; other site 262543002347 putative active site [active] 262543002348 putative CoA binding site [chemical binding]; other site 262543002349 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 262543002350 active site 262543002351 dimer interfaces [polypeptide binding]; other site 262543002352 catalytic residues [active] 262543002353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543002354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543002355 active site 262543002356 phosphorylation site [posttranslational modification] 262543002357 intermolecular recognition site; other site 262543002358 dimerization interface [polypeptide binding]; other site 262543002359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543002360 DNA binding site [nucleotide binding] 262543002361 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 262543002362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543002363 dimerization interface [polypeptide binding]; other site 262543002364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543002365 dimer interface [polypeptide binding]; other site 262543002366 phosphorylation site [posttranslational modification] 262543002367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543002368 ATP binding site [chemical binding]; other site 262543002369 Mg2+ binding site [ion binding]; other site 262543002370 G-X-G motif; other site 262543002371 ComK protein; Region: ComK; cl11560 262543002372 Domain of unknown function (DUF370); Region: DUF370; cl00898 262543002373 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 262543002374 apolar tunnel; other site 262543002375 heme binding site [chemical binding]; other site 262543002376 dimerization interface [polypeptide binding]; other site 262543002377 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 262543002378 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 262543002379 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 262543002380 Part of AAA domain; Region: AAA_19; pfam13245 262543002381 Family description; Region: UvrD_C_2; pfam13538 262543002382 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 262543002383 Response regulator receiver domain; Region: Response_reg; pfam00072 262543002384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543002385 active site 262543002386 phosphorylation site [posttranslational modification] 262543002387 intermolecular recognition site; other site 262543002388 dimerization interface [polypeptide binding]; other site 262543002389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543002390 dimerization interface [polypeptide binding]; other site 262543002391 GAF domain; Region: GAF_3; pfam13492 262543002392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543002393 dimer interface [polypeptide binding]; other site 262543002394 phosphorylation site [posttranslational modification] 262543002395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543002396 ATP binding site [chemical binding]; other site 262543002397 G-X-G motif; other site 262543002398 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 262543002399 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262543002400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543002401 S-adenosylmethionine binding site [chemical binding]; other site 262543002402 phytoene desaturase; Region: crtI_fam; TIGR02734 262543002403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543002404 phytoene desaturase; Region: crtI_fam; TIGR02734 262543002405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543002406 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 262543002407 active site lid residues [active] 262543002408 substrate binding pocket [chemical binding]; other site 262543002409 catalytic residues [active] 262543002410 substrate-Mg2+ binding site; other site 262543002411 aspartate-rich region 1; other site 262543002412 aspartate-rich region 2; other site 262543002413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543002414 phytoene desaturase; Region: crtI_fam; TIGR02734 262543002415 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 262543002416 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 262543002417 active site 262543002418 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 262543002419 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262543002420 putative acyl-acceptor binding pocket; other site 262543002421 Protein of unknown function (DUF422); Region: DUF422; cl00991 262543002422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543002423 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543002424 Probable transposase; Region: OrfB_IS605; pfam01385 262543002425 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543002426 Transposase IS200 like; Region: Y1_Tnp; pfam01797 262543002427 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 262543002428 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 262543002429 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 262543002430 putative deacylase active site [active] 262543002431 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 262543002432 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 262543002433 enoyl-CoA hydratase; Provisional; Region: PRK06688 262543002434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262543002435 substrate binding site [chemical binding]; other site 262543002436 oxyanion hole (OAH) forming residues; other site 262543002437 trimer interface [polypeptide binding]; other site 262543002438 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 262543002439 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 262543002440 maltodextrin glucosidase; Provisional; Region: PRK10785 262543002441 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 262543002442 homodimer interface [polypeptide binding]; other site 262543002443 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 262543002444 active site 262543002445 homodimer interface [polypeptide binding]; other site 262543002446 catalytic site [active] 262543002447 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 262543002448 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 262543002449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262543002450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543002451 dimer interface [polypeptide binding]; other site 262543002452 conserved gate region; other site 262543002453 ABC-ATPase subunit interface; other site 262543002454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262543002455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543002456 dimer interface [polypeptide binding]; other site 262543002457 conserved gate region; other site 262543002458 putative PBP binding loops; other site 262543002459 ABC-ATPase subunit interface; other site 262543002460 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 262543002461 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 262543002462 active site 262543002463 catalytic site [active] 262543002464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262543002465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262543002466 DNA binding site [nucleotide binding] 262543002467 domain linker motif; other site 262543002468 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 262543002469 putative dimerization interface [polypeptide binding]; other site 262543002470 putative ligand binding site [chemical binding]; other site 262543002471 maltose phosphorylase; Provisional; Region: PRK13807 262543002472 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 262543002473 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 262543002474 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 262543002475 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543002476 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543002477 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543002478 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543002479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543002480 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262543002481 active site 262543002482 motif I; other site 262543002483 motif II; other site 262543002484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543002485 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 262543002486 isoaspartyl dipeptidase; Provisional; Region: PRK10657 262543002487 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262543002488 active site 262543002489 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262543002490 catalytic residues [active] 262543002491 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 262543002492 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 262543002493 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 262543002494 transmembrane helices; other site 262543002495 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 262543002496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543002497 motif II; other site 262543002498 GTPase YqeH; Provisional; Region: PRK13796 262543002499 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 262543002500 GTP/Mg2+ binding site [chemical binding]; other site 262543002501 G4 box; other site 262543002502 G5 box; other site 262543002503 G1 box; other site 262543002504 Switch I region; other site 262543002505 G2 box; other site 262543002506 G3 box; other site 262543002507 Switch II region; other site 262543002508 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 262543002509 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 262543002510 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 262543002511 shikimate binding site; other site 262543002512 NAD(P) binding site [chemical binding]; other site 262543002513 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 262543002514 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 262543002515 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 262543002516 active site 262543002517 (T/H)XGH motif; other site 262543002518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543002519 Zn2+ binding site [ion binding]; other site 262543002520 Mg2+ binding site [ion binding]; other site 262543002521 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 262543002522 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262543002523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543002524 S-adenosylmethionine binding site [chemical binding]; other site 262543002525 SLBB domain; Region: SLBB; pfam10531 262543002526 comEA protein; Region: comE; TIGR01259 262543002527 Helix-hairpin-helix motif; Region: HHH; pfam00633 262543002528 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 262543002529 Competence protein; Region: Competence; pfam03772 262543002530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543002531 YqzM-like protein; Region: YqzM; pfam14141 262543002532 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 262543002533 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 262543002534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543002535 Coenzyme A binding pocket [chemical binding]; other site 262543002536 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 262543002537 GTP-binding protein LepA; Provisional; Region: PRK05433 262543002538 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 262543002539 G1 box; other site 262543002540 putative GEF interaction site [polypeptide binding]; other site 262543002541 GTP/Mg2+ binding site [chemical binding]; other site 262543002542 Switch I region; other site 262543002543 G2 box; other site 262543002544 G3 box; other site 262543002545 Switch II region; other site 262543002546 G4 box; other site 262543002547 G5 box; other site 262543002548 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 262543002549 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 262543002550 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 262543002551 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 262543002552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543002553 FeS/SAM binding site; other site 262543002554 HemN C-terminal domain; Region: HemN_C; pfam06969 262543002555 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 262543002556 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 262543002557 heat shock protein GrpE; Provisional; Region: PRK14140 262543002558 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 262543002559 dimer interface [polypeptide binding]; other site 262543002560 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 262543002561 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 262543002562 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 262543002563 nucleotide binding site [chemical binding]; other site 262543002564 NEF interaction site [polypeptide binding]; other site 262543002565 SBD interface [polypeptide binding]; other site 262543002566 chaperone protein DnaJ; Provisional; Region: PRK14280 262543002567 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 262543002568 HSP70 interaction site [polypeptide binding]; other site 262543002569 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 262543002570 Zn binding sites [ion binding]; other site 262543002571 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 262543002572 dimer interface [polypeptide binding]; other site 262543002573 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 262543002574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543002575 S-adenosylmethionine binding site [chemical binding]; other site 262543002576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 262543002577 RNA methyltransferase, RsmE family; Region: TIGR00046 262543002578 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 262543002579 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 262543002580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543002581 FeS/SAM binding site; other site 262543002582 TRAM domain; Region: TRAM; cl01282 262543002583 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 262543002584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543002585 RNA binding surface [nucleotide binding]; other site 262543002586 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 262543002587 probable active site [active] 262543002588 Predicted permeases [General function prediction only]; Region: RarD; COG2962 262543002589 EamA-like transporter family; Region: EamA; pfam00892 262543002590 Predicted permeases [General function prediction only]; Region: RarD; COG2962 262543002591 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 262543002592 intersubunit interface [polypeptide binding]; other site 262543002593 active site 262543002594 catalytic residue [active] 262543002595 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 262543002596 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 262543002597 ligand binding site [chemical binding]; other site 262543002598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543002599 dimerization interface [polypeptide binding]; other site 262543002600 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543002601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543002602 dimer interface [polypeptide binding]; other site 262543002603 putative CheW interface [polypeptide binding]; other site 262543002604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 262543002605 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543002606 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543002607 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262543002608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543002609 NAD(P) binding site [chemical binding]; other site 262543002610 active site 262543002611 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 262543002612 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262543002613 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262543002614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543002615 motif II; other site 262543002616 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 262543002617 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 262543002618 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 262543002619 Prostaglandin dehydrogenases; Region: PGDH; cd05288 262543002620 NAD(P) binding site [chemical binding]; other site 262543002621 substrate binding site [chemical binding]; other site 262543002622 dimer interface [polypeptide binding]; other site 262543002623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 262543002624 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 262543002625 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262543002626 active site 262543002627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543002628 S-adenosylmethionine binding site [chemical binding]; other site 262543002629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543002630 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 262543002631 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262543002632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543002633 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 262543002634 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 262543002635 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262543002636 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 262543002637 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 262543002638 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 262543002639 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 262543002640 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 262543002641 Walker A/P-loop; other site 262543002642 ATP binding site [chemical binding]; other site 262543002643 Q-loop/lid; other site 262543002644 ABC transporter signature motif; other site 262543002645 Walker B; other site 262543002646 D-loop; other site 262543002647 H-loop/switch region; other site 262543002648 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 262543002649 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 262543002650 active site 262543002651 homodimer interface [polypeptide binding]; other site 262543002652 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 262543002653 DHHW protein; Region: DHHW; pfam14286 262543002654 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262543002655 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 262543002656 carbohydrate binding site [chemical binding]; other site 262543002657 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 262543002658 carbohydrate binding site [chemical binding]; other site 262543002659 pullulanase, type I; Region: pulA_typeI; TIGR02104 262543002660 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 262543002661 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 262543002662 Ca binding site [ion binding]; other site 262543002663 active site 262543002664 catalytic site [active] 262543002665 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 262543002666 Yqey-like protein; Region: YqeY; pfam09424 262543002667 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 262543002668 hypothetical protein; Provisional; Region: PRK13665 262543002669 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 262543002670 PhoH-like protein; Region: PhoH; pfam02562 262543002671 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 262543002672 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 262543002673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543002674 Zn2+ binding site [ion binding]; other site 262543002675 Mg2+ binding site [ion binding]; other site 262543002676 metal-binding heat shock protein; Provisional; Region: PRK00016 262543002677 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 262543002678 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 262543002679 active site 262543002680 catalytic motif [active] 262543002681 Zn binding site [ion binding]; other site 262543002682 GTPase Era; Reviewed; Region: era; PRK00089 262543002683 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 262543002684 G1 box; other site 262543002685 GTP/Mg2+ binding site [chemical binding]; other site 262543002686 Switch I region; other site 262543002687 G2 box; other site 262543002688 Switch II region; other site 262543002689 G3 box; other site 262543002690 G4 box; other site 262543002691 G5 box; other site 262543002692 KH domain; Region: KH_2; pfam07650 262543002693 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 262543002694 Recombination protein O N terminal; Region: RecO_N; pfam11967 262543002695 Recombination protein O C terminal; Region: RecO_C; pfam02565 262543002696 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 262543002697 dimer interface [polypeptide binding]; other site 262543002698 motif 1; other site 262543002699 active site 262543002700 motif 2; other site 262543002701 motif 3; other site 262543002702 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 262543002703 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262543002704 HTH domain; Region: HTH_11; pfam08279 262543002705 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 262543002706 FOG: CBS domain [General function prediction only]; Region: COG0517 262543002707 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 262543002708 DNA primase; Validated; Region: dnaG; PRK05667 262543002709 CHC2 zinc finger; Region: zf-CHC2; pfam01807 262543002710 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 262543002711 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 262543002712 active site 262543002713 metal binding site [ion binding]; metal-binding site 262543002714 interdomain interaction site; other site 262543002715 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 262543002716 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 262543002717 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 262543002718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543002719 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262543002720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543002721 DNA binding residues [nucleotide binding] 262543002722 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 262543002723 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 262543002724 Family of unknown function (DUF633); Region: DUF633; pfam04816 262543002725 Uncharacterized conserved protein [Function unknown]; Region: COG0327 262543002726 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 262543002727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 262543002728 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 262543002729 Uncharacterized conserved protein [Function unknown]; Region: COG0327 262543002730 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 262543002731 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 262543002732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543002733 HAMP domain; Region: HAMP; pfam00672 262543002734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543002735 dimer interface [polypeptide binding]; other site 262543002736 phosphorylation site [posttranslational modification] 262543002737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543002738 ATP binding site [chemical binding]; other site 262543002739 Mg2+ binding site [ion binding]; other site 262543002740 G-X-G motif; other site 262543002741 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 262543002742 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 262543002743 ligand binding site [chemical binding]; other site 262543002744 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 262543002745 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262543002746 ATP binding site [chemical binding]; other site 262543002747 Mg++ binding site [ion binding]; other site 262543002748 motif III; other site 262543002749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543002750 nucleotide binding region [chemical binding]; other site 262543002751 ATP-binding site [chemical binding]; other site 262543002752 endonuclease IV; Provisional; Region: PRK01060 262543002753 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 262543002754 AP (apurinic/apyrimidinic) site pocket; other site 262543002755 DNA interaction; other site 262543002756 Metal-binding active site; metal-binding site 262543002757 FeoA domain; Region: FeoA; pfam04023 262543002758 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 262543002759 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 262543002760 G1 box; other site 262543002761 GTP/Mg2+ binding site [chemical binding]; other site 262543002762 Switch I region; other site 262543002763 G2 box; other site 262543002764 G3 box; other site 262543002765 Switch II region; other site 262543002766 G4 box; other site 262543002767 G5 box; other site 262543002768 Nucleoside recognition; Region: Gate; pfam07670 262543002769 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 262543002770 Nucleoside recognition; Region: Gate; pfam07670 262543002771 polyphosphate kinase; Provisional; Region: PRK05443 262543002772 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 262543002773 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 262543002774 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 262543002775 putative domain interface [polypeptide binding]; other site 262543002776 putative active site [active] 262543002777 catalytic site [active] 262543002778 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 262543002779 putative domain interface [polypeptide binding]; other site 262543002780 putative active site [active] 262543002781 catalytic site [active] 262543002782 exopolyphosphatase; Region: exo_poly_only; TIGR03706 262543002783 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 262543002784 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262543002785 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 262543002786 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 262543002787 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543002788 ABC-ATPase subunit interface; other site 262543002789 dimer interface [polypeptide binding]; other site 262543002790 putative PBP binding regions; other site 262543002791 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262543002792 metal binding site 2 [ion binding]; metal-binding site 262543002793 putative DNA binding helix; other site 262543002794 metal binding site 1 [ion binding]; metal-binding site 262543002795 dimer interface [polypeptide binding]; other site 262543002796 structural Zn2+ binding site [ion binding]; other site 262543002797 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 262543002798 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 262543002799 putative substrate binding site [chemical binding]; other site 262543002800 putative ATP binding site [chemical binding]; other site 262543002801 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 262543002802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543002803 Uncharacterized conserved protein [Function unknown]; Region: COG5663 262543002804 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 262543002805 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 262543002806 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 262543002807 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 262543002808 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 262543002809 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 262543002810 PhoU domain; Region: PhoU; pfam01895 262543002811 PhoU domain; Region: PhoU; pfam01895 262543002812 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 262543002813 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 262543002814 active site 262543002815 Na/Ca binding site [ion binding]; other site 262543002816 catalytic site [active] 262543002817 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 262543002818 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 262543002819 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 262543002820 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262543002821 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 262543002822 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 262543002823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262543002824 PBP superfamily domain; Region: PBP_like_2; cl17296 262543002825 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 262543002826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543002827 dimer interface [polypeptide binding]; other site 262543002828 conserved gate region; other site 262543002829 putative PBP binding loops; other site 262543002830 ABC-ATPase subunit interface; other site 262543002831 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 262543002832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543002833 dimer interface [polypeptide binding]; other site 262543002834 conserved gate region; other site 262543002835 putative PBP binding loops; other site 262543002836 ABC-ATPase subunit interface; other site 262543002837 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 262543002838 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 262543002839 Walker A/P-loop; other site 262543002840 ATP binding site [chemical binding]; other site 262543002841 Q-loop/lid; other site 262543002842 ABC transporter signature motif; other site 262543002843 Walker B; other site 262543002844 D-loop; other site 262543002845 H-loop/switch region; other site 262543002846 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 262543002847 PhoU domain; Region: PhoU; pfam01895 262543002848 PhoU domain; Region: PhoU; pfam01895 262543002849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 262543002850 Uncharacterized conserved protein [Function unknown]; Region: COG1543 262543002851 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 262543002852 active site 262543002853 substrate binding site [chemical binding]; other site 262543002854 catalytic site [active] 262543002855 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 262543002856 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262543002857 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 262543002858 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 262543002859 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 262543002860 Integral membrane protein DUF92; Region: DUF92; pfam01940 262543002861 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 262543002862 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 262543002863 NAD binding site [chemical binding]; other site 262543002864 dimer interface [polypeptide binding]; other site 262543002865 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262543002866 substrate binding site [chemical binding]; other site 262543002867 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 262543002868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543002869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543002870 Coenzyme A binding pocket [chemical binding]; other site 262543002871 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262543002872 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 262543002873 putative oligomer interface [polypeptide binding]; other site 262543002874 putative active site [active] 262543002875 metal binding site [ion binding]; metal-binding site 262543002876 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 262543002877 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 262543002878 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 262543002879 nucleotide binding site [chemical binding]; other site 262543002880 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 262543002881 Sulfatase; Region: Sulfatase; pfam00884 262543002882 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 262543002883 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 262543002884 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 262543002885 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 262543002886 ArsC family; Region: ArsC; pfam03960 262543002887 putative catalytic residues [active] 262543002888 thiol/disulfide switch; other site 262543002889 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262543002890 Walker A motif; other site 262543002891 ATP binding site [chemical binding]; other site 262543002892 Walker B motif; other site 262543002893 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 262543002894 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 262543002895 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 262543002896 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 262543002897 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 262543002898 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 262543002899 ADP binding site [chemical binding]; other site 262543002900 magnesium binding site [ion binding]; other site 262543002901 putative shikimate binding site; other site 262543002902 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 262543002903 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 262543002904 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 262543002905 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 262543002906 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 262543002907 tetramer interface [polypeptide binding]; other site 262543002908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543002909 catalytic residue [active] 262543002910 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 262543002911 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 262543002912 tetramer interface [polypeptide binding]; other site 262543002913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543002914 catalytic residue [active] 262543002915 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262543002916 active site residue [active] 262543002917 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 262543002918 manganese transport transcriptional regulator; Provisional; Region: PRK03902 262543002919 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 262543002920 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 262543002921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543002922 active site 262543002923 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 262543002924 Dehydroquinase class II; Region: DHquinase_II; pfam01220 262543002925 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 262543002926 active site 262543002927 trimer interface [polypeptide binding]; other site 262543002928 dimer interface [polypeptide binding]; other site 262543002929 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262543002930 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262543002931 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 262543002932 active site 262543002933 elongation factor P; Validated; Region: PRK00529 262543002934 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 262543002935 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 262543002936 RNA binding site [nucleotide binding]; other site 262543002937 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 262543002938 RNA binding site [nucleotide binding]; other site 262543002939 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 262543002940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262543002941 carboxyltransferase (CT) interaction site; other site 262543002942 biotinylation site [posttranslational modification]; other site 262543002943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 262543002944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262543002945 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543002946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 262543002947 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 262543002948 putative RNA binding site [nucleotide binding]; other site 262543002949 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 262543002950 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 262543002951 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 262543002952 homodimer interface [polypeptide binding]; other site 262543002953 NADP binding site [chemical binding]; other site 262543002954 substrate binding site [chemical binding]; other site 262543002955 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 262543002956 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 262543002957 generic binding surface II; other site 262543002958 generic binding surface I; other site 262543002959 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 262543002960 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262543002961 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262543002962 substrate binding pocket [chemical binding]; other site 262543002963 chain length determination region; other site 262543002964 substrate-Mg2+ binding site; other site 262543002965 catalytic residues [active] 262543002966 aspartate-rich region 1; other site 262543002967 active site lid residues [active] 262543002968 aspartate-rich region 2; other site 262543002969 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 262543002970 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 262543002971 TPP-binding site; other site 262543002972 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262543002973 PYR/PP interface [polypeptide binding]; other site 262543002974 dimer interface [polypeptide binding]; other site 262543002975 TPP binding site [chemical binding]; other site 262543002976 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262543002977 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 262543002978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543002979 RNA binding surface [nucleotide binding]; other site 262543002980 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 262543002981 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 262543002982 arginine repressor; Provisional; Region: PRK04280 262543002983 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 262543002984 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 262543002985 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 262543002986 Walker A/P-loop; other site 262543002987 ATP binding site [chemical binding]; other site 262543002988 Q-loop/lid; other site 262543002989 UDP-glycosyltransferase; Region: PLN02534 262543002990 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 262543002991 Q-loop/lid; other site 262543002992 ABC transporter signature motif; other site 262543002993 Walker B; other site 262543002994 D-loop; other site 262543002995 H-loop/switch region; other site 262543002996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543002997 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 262543002998 active site 262543002999 phosphorylation site [posttranslational modification] 262543003000 intermolecular recognition site; other site 262543003001 dimerization interface [polypeptide binding]; other site 262543003002 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 262543003003 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 262543003004 PAS domain S-box; Region: sensory_box; TIGR00229 262543003005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543003006 putative active site [active] 262543003007 heme pocket [chemical binding]; other site 262543003008 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 262543003009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543003010 Walker A motif; other site 262543003011 ATP binding site [chemical binding]; other site 262543003012 Walker B motif; other site 262543003013 arginine finger; other site 262543003014 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 262543003015 phosphate butyryltransferase; Validated; Region: PRK07742 262543003016 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 262543003017 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 262543003018 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 262543003019 NAD binding site [chemical binding]; other site 262543003020 Phe binding site; other site 262543003021 butyrate kinase; Provisional; Region: PRK03011 262543003022 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 262543003023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543003024 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543003025 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 262543003026 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262543003027 tetramer interface [polypeptide binding]; other site 262543003028 TPP-binding site [chemical binding]; other site 262543003029 heterodimer interface [polypeptide binding]; other site 262543003030 phosphorylation loop region [posttranslational modification] 262543003031 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262543003032 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262543003033 alpha subunit interface [polypeptide binding]; other site 262543003034 TPP binding site [chemical binding]; other site 262543003035 heterodimer interface [polypeptide binding]; other site 262543003036 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262543003037 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 262543003038 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262543003039 E3 interaction surface; other site 262543003040 lipoyl attachment site [posttranslational modification]; other site 262543003041 e3 binding domain; Region: E3_binding; pfam02817 262543003042 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262543003043 anthranilate synthase component I; Provisional; Region: PRK13570 262543003044 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 262543003045 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 262543003046 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 262543003047 Glutamine amidotransferase class-I; Region: GATase; pfam00117 262543003048 glutamine binding [chemical binding]; other site 262543003049 catalytic triad [active] 262543003050 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 262543003051 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262543003052 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262543003053 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 262543003054 active site 262543003055 ribulose/triose binding site [chemical binding]; other site 262543003056 phosphate binding site [ion binding]; other site 262543003057 substrate (anthranilate) binding pocket [chemical binding]; other site 262543003058 product (indole) binding pocket [chemical binding]; other site 262543003059 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 262543003060 active site 262543003061 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 262543003062 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 262543003063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543003064 catalytic residue [active] 262543003065 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 262543003066 substrate binding site [chemical binding]; other site 262543003067 active site 262543003068 catalytic residues [active] 262543003069 heterodimer interface [polypeptide binding]; other site 262543003070 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 262543003071 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262543003072 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 262543003073 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262543003074 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003075 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543003076 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543003077 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 262543003078 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 262543003079 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 262543003080 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 262543003081 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262543003082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543003083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543003084 ABC transporter; Region: ABC_tran_2; pfam12848 262543003085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543003086 Predicted secreted protein [Function unknown]; Region: COG4086 262543003087 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 262543003088 Putative transcription activator [Transcription]; Region: TenA; COG0819 262543003089 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 262543003090 SpoOM protein; Region: Spo0M; pfam07070 262543003091 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262543003092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543003093 S-adenosylmethionine binding site [chemical binding]; other site 262543003094 Disulphide isomerase; Region: Disulph_isomer; pfam06491 262543003095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262543003096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262543003097 substrate binding pocket [chemical binding]; other site 262543003098 membrane-bound complex binding site; other site 262543003099 hinge residues; other site 262543003100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543003101 dimer interface [polypeptide binding]; other site 262543003102 conserved gate region; other site 262543003103 putative PBP binding loops; other site 262543003104 ABC-ATPase subunit interface; other site 262543003105 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262543003106 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 262543003107 Walker A/P-loop; other site 262543003108 ATP binding site [chemical binding]; other site 262543003109 Q-loop/lid; other site 262543003110 ABC transporter signature motif; other site 262543003111 Walker B; other site 262543003112 D-loop; other site 262543003113 H-loop/switch region; other site 262543003114 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 262543003115 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543003116 Zn2+ binding site [ion binding]; other site 262543003117 Mg2+ binding site [ion binding]; other site 262543003118 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 262543003119 short chain dehydrogenase; Provisional; Region: PRK07677 262543003120 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 262543003121 NAD(P) binding site [chemical binding]; other site 262543003122 substrate binding site [chemical binding]; other site 262543003123 homotetramer interface [polypeptide binding]; other site 262543003124 active site 262543003125 homodimer interface [polypeptide binding]; other site 262543003126 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 262543003127 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 262543003128 DHHA2 domain; Region: DHHA2; pfam02833 262543003129 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 262543003130 Predicted membrane protein [Function unknown]; Region: COG4129 262543003131 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 262543003132 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 262543003133 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 262543003134 peptidase T-like protein; Region: PepT-like; TIGR01883 262543003135 metal binding site [ion binding]; metal-binding site 262543003136 putative dimer interface [polypeptide binding]; other site 262543003137 ribonuclease Z; Region: RNase_Z; TIGR02651 262543003138 murein transglycosylase A; Provisional; Region: mltA; PRK11162 262543003139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543003140 ABC transporter signature motif; other site 262543003141 Walker B; other site 262543003142 D-loop; other site 262543003143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 262543003144 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 262543003145 Walker A/P-loop; other site 262543003146 ATP binding site [chemical binding]; other site 262543003147 Q-loop/lid; other site 262543003148 ABC transporter signature motif; other site 262543003149 Walker B; other site 262543003150 D-loop; other site 262543003151 H-loop/switch region; other site 262543003152 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262543003153 classical (c) SDRs; Region: SDR_c; cd05233 262543003154 NAD(P) binding site [chemical binding]; other site 262543003155 active site 262543003156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543003157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003159 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 262543003160 EamA-like transporter family; Region: EamA; pfam00892 262543003161 DNA topoisomerase III; Provisional; Region: PRK07726 262543003162 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 262543003163 active site 262543003164 putative interdomain interaction site [polypeptide binding]; other site 262543003165 putative metal-binding site [ion binding]; other site 262543003166 putative nucleotide binding site [chemical binding]; other site 262543003167 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 262543003168 domain I; other site 262543003169 DNA binding groove [nucleotide binding] 262543003170 phosphate binding site [ion binding]; other site 262543003171 domain II; other site 262543003172 domain III; other site 262543003173 nucleotide binding site [chemical binding]; other site 262543003174 catalytic site [active] 262543003175 domain IV; other site 262543003176 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 262543003177 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 262543003178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543003179 dimerization interface [polypeptide binding]; other site 262543003180 GAF domain; Region: GAF_3; pfam13492 262543003181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543003182 dimer interface [polypeptide binding]; other site 262543003183 phosphorylation site [posttranslational modification] 262543003184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543003185 ATP binding site [chemical binding]; other site 262543003186 Mg2+ binding site [ion binding]; other site 262543003187 G-X-G motif; other site 262543003188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003189 putative substrate translocation pore; other site 262543003190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543003191 H+ Antiporter protein; Region: 2A0121; TIGR00900 262543003192 ABC-2 type transporter; Region: ABC2_membrane; cl17235 262543003193 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 262543003194 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 262543003195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262543003196 Walker A/P-loop; other site 262543003197 ATP binding site [chemical binding]; other site 262543003198 Q-loop/lid; other site 262543003199 ABC transporter signature motif; other site 262543003200 Walker B; other site 262543003201 D-loop; other site 262543003202 H-loop/switch region; other site 262543003203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543003205 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262543003206 FAD binding domain; Region: FAD_binding_4; pfam01565 262543003207 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 262543003208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262543003209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543003210 dimer interface [polypeptide binding]; other site 262543003211 conserved gate region; other site 262543003212 putative PBP binding loops; other site 262543003213 ABC-ATPase subunit interface; other site 262543003214 Protein of unknown function DUF58; Region: DUF58; pfam01882 262543003215 MoxR-like ATPases [General function prediction only]; Region: COG0714 262543003216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543003217 Walker A motif; other site 262543003218 ATP binding site [chemical binding]; other site 262543003219 Walker B motif; other site 262543003220 arginine finger; other site 262543003221 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 262543003222 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262543003223 NAD binding site [chemical binding]; other site 262543003224 substrate binding site [chemical binding]; other site 262543003225 putative active site [active] 262543003226 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 262543003227 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 262543003228 active site 262543003229 Na/Ca binding site [ion binding]; other site 262543003230 catalytic site [active] 262543003231 Endonuclease I; Region: Endonuclease_1; pfam04231 262543003232 Uncharacterized conserved protein [Function unknown]; Region: COG1434 262543003233 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 262543003234 putative active site [active] 262543003235 Response regulator receiver domain; Region: Response_reg; pfam00072 262543003236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543003237 active site 262543003238 phosphorylation site [posttranslational modification] 262543003239 intermolecular recognition site; other site 262543003240 dimerization interface [polypeptide binding]; other site 262543003241 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 262543003242 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 262543003243 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 262543003244 Cl binding site [ion binding]; other site 262543003245 oligomer interface [polypeptide binding]; other site 262543003246 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543003247 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543003248 Integrase core domain; Region: rve; pfam00665 262543003249 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 262543003250 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 262543003251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543003252 active site 262543003253 phosphorylation site [posttranslational modification] 262543003254 intermolecular recognition site; other site 262543003255 dimerization interface [polypeptide binding]; other site 262543003256 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 262543003257 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 262543003258 tetrameric interface [polypeptide binding]; other site 262543003259 activator binding site; other site 262543003260 NADP binding site [chemical binding]; other site 262543003261 substrate binding site [chemical binding]; other site 262543003262 catalytic residues [active] 262543003263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543003264 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262543003265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543003266 NAD(P) binding site [chemical binding]; other site 262543003267 active site 262543003268 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 262543003269 hypothetical protein; Provisional; Region: PRK11622 262543003270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543003271 dimer interface [polypeptide binding]; other site 262543003272 conserved gate region; other site 262543003273 putative PBP binding loops; other site 262543003274 ABC-ATPase subunit interface; other site 262543003275 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262543003276 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 262543003277 Walker A/P-loop; other site 262543003278 ATP binding site [chemical binding]; other site 262543003279 Q-loop/lid; other site 262543003280 ABC transporter signature motif; other site 262543003281 Walker B; other site 262543003282 D-loop; other site 262543003283 H-loop/switch region; other site 262543003284 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 262543003285 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 262543003286 nudix motif; other site 262543003287 Predicted transcriptional regulators [Transcription]; Region: COG1695 262543003288 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 262543003289 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 262543003290 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 262543003291 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 262543003292 potential catalytic triad [active] 262543003293 conserved cys residue [active] 262543003294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543003295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543003296 active site 262543003297 catalytic tetrad [active] 262543003298 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 262543003299 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 262543003300 dimer interface [polypeptide binding]; other site 262543003301 ADP-ribose binding site [chemical binding]; other site 262543003302 active site 262543003303 nudix motif; other site 262543003304 metal binding site [ion binding]; metal-binding site 262543003305 ferric uptake regulator; Provisional; Region: fur; PRK09462 262543003306 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262543003307 metal binding site 2 [ion binding]; metal-binding site 262543003308 putative DNA binding helix; other site 262543003309 metal binding site 1 [ion binding]; metal-binding site 262543003310 dimer interface [polypeptide binding]; other site 262543003311 structural Zn2+ binding site [ion binding]; other site 262543003312 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 262543003313 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 262543003314 active site 262543003315 Int/Topo IB signature motif; other site 262543003316 phosphopentomutase; Provisional; Region: PRK05362 262543003317 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 262543003318 purine nucleoside phosphorylase; Provisional; Region: PRK08202 262543003319 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 262543003320 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262543003321 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262543003322 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 262543003323 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 262543003324 putative dimer interface [polypeptide binding]; other site 262543003325 catalytic triad [active] 262543003326 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262543003327 active site 262543003328 intracellular protease, PfpI family; Region: PfpI; TIGR01382 262543003329 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 262543003330 proposed catalytic triad [active] 262543003331 conserved cys residue [active] 262543003332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 262543003333 Domain of unknown function (DUF309); Region: DUF309; pfam03745 262543003334 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 262543003335 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 262543003336 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 262543003337 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543003338 RNA binding surface [nucleotide binding]; other site 262543003339 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 262543003340 active site 262543003341 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 262543003342 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 262543003343 catalytic residues [active] 262543003344 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 262543003345 ResB-like family; Region: ResB; pfam05140 262543003346 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 262543003347 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 262543003348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543003349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543003350 active site 262543003351 phosphorylation site [posttranslational modification] 262543003352 intermolecular recognition site; other site 262543003353 dimerization interface [polypeptide binding]; other site 262543003354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543003355 DNA binding site [nucleotide binding] 262543003356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 262543003357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543003358 dimerization interface [polypeptide binding]; other site 262543003359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543003360 dimer interface [polypeptide binding]; other site 262543003361 phosphorylation site [posttranslational modification] 262543003362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543003363 ATP binding site [chemical binding]; other site 262543003364 Mg2+ binding site [ion binding]; other site 262543003365 G-X-G motif; other site 262543003366 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 262543003367 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 262543003368 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 262543003369 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 262543003370 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 262543003371 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 262543003372 classical (c) SDRs; Region: SDR_c; cd05233 262543003373 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262543003374 NAD(P) binding site [chemical binding]; other site 262543003375 active site 262543003376 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 262543003377 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 262543003378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543003379 non-specific DNA binding site [nucleotide binding]; other site 262543003380 salt bridge; other site 262543003381 sequence-specific DNA binding site [nucleotide binding]; other site 262543003382 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 262543003383 competence damage-inducible protein A; Provisional; Region: PRK00549 262543003384 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 262543003385 putative MPT binding site; other site 262543003386 Competence-damaged protein; Region: CinA; pfam02464 262543003387 recombinase A; Provisional; Region: recA; PRK09354 262543003388 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 262543003389 hexamer interface [polypeptide binding]; other site 262543003390 Walker A motif; other site 262543003391 ATP binding site [chemical binding]; other site 262543003392 Walker B motif; other site 262543003393 phosphodiesterase; Provisional; Region: PRK12704 262543003394 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543003395 Zn2+ binding site [ion binding]; other site 262543003396 Mg2+ binding site [ion binding]; other site 262543003397 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 262543003398 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262543003399 putative active site [active] 262543003400 metal binding site [ion binding]; metal-binding site 262543003401 homodimer binding site [polypeptide binding]; other site 262543003402 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 262543003403 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 262543003404 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 262543003405 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 262543003406 dimer interface [polypeptide binding]; other site 262543003407 PYR/PP interface [polypeptide binding]; other site 262543003408 TPP binding site [chemical binding]; other site 262543003409 substrate binding site [chemical binding]; other site 262543003410 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 262543003411 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 262543003412 TPP-binding site [chemical binding]; other site 262543003413 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 262543003414 Threonine dehydrogenase; Region: TDH; cd05281 262543003415 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 262543003416 structural Zn binding site [ion binding]; other site 262543003417 catalytic Zn binding site [ion binding]; other site 262543003418 tetramer interface [polypeptide binding]; other site 262543003419 NADP binding site [chemical binding]; other site 262543003420 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 262543003421 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 262543003422 substrate-cofactor binding pocket; other site 262543003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543003424 catalytic residue [active] 262543003425 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 262543003426 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 262543003427 Walker A/P-loop; other site 262543003428 ATP binding site [chemical binding]; other site 262543003429 Q-loop/lid; other site 262543003430 ABC transporter signature motif; other site 262543003431 Walker B; other site 262543003432 D-loop; other site 262543003433 H-loop/switch region; other site 262543003434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 262543003435 ABC-ATPase subunit interface; other site 262543003436 dimer interface [polypeptide binding]; other site 262543003437 putative PBP binding regions; other site 262543003438 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 262543003439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543003440 ABC-ATPase subunit interface; other site 262543003441 dimer interface [polypeptide binding]; other site 262543003442 putative PBP binding regions; other site 262543003443 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 262543003444 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 262543003445 intersubunit interface [polypeptide binding]; other site 262543003446 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 262543003447 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 262543003448 PGAP1-like protein; Region: PGAP1; pfam07819 262543003449 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 262543003450 Protein of unknown function (DUF445); Region: DUF445; pfam04286 262543003451 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 262543003452 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262543003453 minor groove reading motif; other site 262543003454 helix-hairpin-helix signature motif; other site 262543003455 substrate binding pocket [chemical binding]; other site 262543003456 active site 262543003457 Predicted membrane protein [Function unknown]; Region: COG4550 262543003458 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 262543003459 MutS domain I; Region: MutS_I; pfam01624 262543003460 MutS domain II; Region: MutS_II; pfam05188 262543003461 MutS domain III; Region: MutS_III; pfam05192 262543003462 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 262543003463 Walker A/P-loop; other site 262543003464 ATP binding site [chemical binding]; other site 262543003465 Q-loop/lid; other site 262543003466 ABC transporter signature motif; other site 262543003467 Walker B; other site 262543003468 D-loop; other site 262543003469 H-loop/switch region; other site 262543003470 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 262543003471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543003472 ATP binding site [chemical binding]; other site 262543003473 Mg2+ binding site [ion binding]; other site 262543003474 G-X-G motif; other site 262543003475 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 262543003476 ATP binding site [chemical binding]; other site 262543003477 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 262543003478 LrgB-like family; Region: LrgB; cl00596 262543003479 AAA domain; Region: AAA_18; pfam13238 262543003480 Shikimate kinase; Region: SKI; pfam01202 262543003481 GAF domain; Region: GAF_3; pfam13492 262543003482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543003483 dimer interface [polypeptide binding]; other site 262543003484 phosphorylation site [posttranslational modification] 262543003485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543003486 ATP binding site [chemical binding]; other site 262543003487 Mg2+ binding site [ion binding]; other site 262543003488 G-X-G motif; other site 262543003489 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 262543003490 Class III ribonucleotide reductase; Region: RNR_III; cd01675 262543003491 effector binding site; other site 262543003492 active site 262543003493 Zn binding site [ion binding]; other site 262543003494 glycine loop; other site 262543003495 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 262543003496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543003497 FeS/SAM binding site; other site 262543003498 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262543003499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003500 putative substrate translocation pore; other site 262543003501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262543003503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543003504 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 262543003505 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 262543003506 Sulfate transporter family; Region: Sulfate_transp; pfam00916 262543003507 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 262543003508 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 262543003509 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 262543003510 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 262543003511 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 262543003512 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 262543003513 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 262543003514 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 262543003515 putative substrate binding site [chemical binding]; other site 262543003516 putative ATP binding site [chemical binding]; other site 262543003517 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 262543003518 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 262543003519 active site 262543003520 phosphorylation site [posttranslational modification] 262543003521 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 262543003522 active site 262543003523 P-loop; other site 262543003524 phosphorylation site [posttranslational modification] 262543003525 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 262543003526 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 262543003527 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 262543003528 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 262543003529 cofactor binding site; other site 262543003530 metal binding site [ion binding]; metal-binding site 262543003531 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 262543003532 putative nucleotide binding site [chemical binding]; other site 262543003533 putative metal binding site [ion binding]; other site 262543003534 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262543003535 DNA binding site [nucleotide binding] 262543003536 active site 262543003537 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 262543003538 Cation efflux family; Region: Cation_efflux; pfam01545 262543003539 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 262543003540 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 262543003541 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 262543003542 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 262543003543 H+ Antiporter protein; Region: 2A0121; TIGR00900 262543003544 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543003545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543003546 non-specific DNA binding site [nucleotide binding]; other site 262543003547 salt bridge; other site 262543003548 sequence-specific DNA binding site [nucleotide binding]; other site 262543003549 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003550 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003551 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003552 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262543003553 NlpC/P60 family; Region: NLPC_P60; pfam00877 262543003554 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262543003555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543003556 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 262543003557 Walker A/P-loop; other site 262543003558 ATP binding site [chemical binding]; other site 262543003559 Q-loop/lid; other site 262543003560 ABC transporter signature motif; other site 262543003561 Walker B; other site 262543003562 D-loop; other site 262543003563 H-loop/switch region; other site 262543003564 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 262543003565 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 262543003566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543003567 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262543003568 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262543003569 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 262543003570 protein binding site [polypeptide binding]; other site 262543003571 Predicted membrane protein [Function unknown]; Region: COG4270 262543003572 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 262543003573 active site 262543003574 catalytic triad [active] 262543003575 oxyanion hole [active] 262543003576 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262543003577 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 262543003578 Walker A/P-loop; other site 262543003579 ATP binding site [chemical binding]; other site 262543003580 Q-loop/lid; other site 262543003581 ABC transporter signature motif; other site 262543003582 Walker B; other site 262543003583 D-loop; other site 262543003584 H-loop/switch region; other site 262543003585 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 262543003586 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 262543003587 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 262543003588 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 262543003589 bacterial Hfq-like; Region: Hfq; cd01716 262543003590 hexamer interface [polypeptide binding]; other site 262543003591 Sm1 motif; other site 262543003592 RNA binding site [nucleotide binding]; other site 262543003593 Sm2 motif; other site 262543003594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262543003595 active site 262543003596 Int/Topo IB signature motif; other site 262543003597 DNA binding site [nucleotide binding] 262543003598 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 262543003599 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 262543003600 HflX GTPase family; Region: HflX; cd01878 262543003601 G1 box; other site 262543003602 GTP/Mg2+ binding site [chemical binding]; other site 262543003603 Switch I region; other site 262543003604 G2 box; other site 262543003605 G3 box; other site 262543003606 Switch II region; other site 262543003607 G4 box; other site 262543003608 G5 box; other site 262543003609 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 262543003610 Aluminium resistance protein; Region: Alum_res; pfam06838 262543003611 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 262543003612 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262543003613 DNA binding residues [nucleotide binding] 262543003614 putative dimer interface [polypeptide binding]; other site 262543003615 glutamine synthetase, type I; Region: GlnA; TIGR00653 262543003616 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262543003617 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262543003618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543003619 Coenzyme A binding pocket [chemical binding]; other site 262543003620 Predicted membrane protein [Function unknown]; Region: COG4392 262543003621 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 262543003622 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 262543003623 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 262543003624 DAK2 domain; Region: Dak2; cl03685 262543003625 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 262543003626 glycerol kinase; Provisional; Region: glpK; PRK00047 262543003627 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 262543003628 N- and C-terminal domain interface [polypeptide binding]; other site 262543003629 active site 262543003630 MgATP binding site [chemical binding]; other site 262543003631 catalytic site [active] 262543003632 metal binding site [ion binding]; metal-binding site 262543003633 glycerol binding site [chemical binding]; other site 262543003634 homotetramer interface [polypeptide binding]; other site 262543003635 homodimer interface [polypeptide binding]; other site 262543003636 FBP binding site [chemical binding]; other site 262543003637 protein IIAGlc interface [polypeptide binding]; other site 262543003638 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 262543003639 amphipathic channel; other site 262543003640 Asn-Pro-Ala signature motifs; other site 262543003641 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 262543003642 LexA repressor; Validated; Region: PRK00215 262543003643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543003644 putative DNA binding site [nucleotide binding]; other site 262543003645 putative Zn2+ binding site [ion binding]; other site 262543003646 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 262543003647 Catalytic site [active] 262543003648 cell division suppressor protein YneA; Provisional; Region: PRK14125 262543003649 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 262543003650 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 262543003651 catalytic residues [active] 262543003652 catalytic nucleophile [active] 262543003653 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 262543003654 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 262543003655 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 262543003656 TPP-binding site [chemical binding]; other site 262543003657 dimer interface [polypeptide binding]; other site 262543003658 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262543003659 PYR/PP interface [polypeptide binding]; other site 262543003660 dimer interface [polypeptide binding]; other site 262543003661 TPP binding site [chemical binding]; other site 262543003662 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262543003663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 262543003664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543003665 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 262543003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543003667 Walker A/P-loop; other site 262543003668 ATP binding site [chemical binding]; other site 262543003669 Q-loop/lid; other site 262543003670 ABC transporter signature motif; other site 262543003671 Walker B; other site 262543003672 D-loop; other site 262543003673 H-loop/switch region; other site 262543003674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262543003675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543003676 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 262543003677 Walker A/P-loop; other site 262543003678 ATP binding site [chemical binding]; other site 262543003679 Q-loop/lid; other site 262543003680 ABC transporter signature motif; other site 262543003681 Walker B; other site 262543003682 D-loop; other site 262543003683 H-loop/switch region; other site 262543003684 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003685 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003686 3D domain; Region: 3D; cl01439 262543003687 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262543003688 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 262543003689 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 262543003690 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 262543003691 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 262543003692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543003693 dimer interface [polypeptide binding]; other site 262543003694 putative metal binding site [ion binding]; other site 262543003695 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 262543003696 putative dimer interface [polypeptide binding]; other site 262543003697 catalytic triad [active] 262543003698 Rrf2 family protein; Region: rrf2_super; TIGR00738 262543003699 Transcriptional regulator; Region: Rrf2; pfam02082 262543003700 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 262543003701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543003702 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543003703 Probable transposase; Region: OrfB_IS605; pfam01385 262543003704 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543003705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543003707 putative substrate translocation pore; other site 262543003708 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 262543003709 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 262543003710 G1 box; other site 262543003711 putative GEF interaction site [polypeptide binding]; other site 262543003712 GTP/Mg2+ binding site [chemical binding]; other site 262543003713 Switch I region; other site 262543003714 G2 box; other site 262543003715 G3 box; other site 262543003716 Switch II region; other site 262543003717 G4 box; other site 262543003718 G5 box; other site 262543003719 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 262543003720 Heat induced stress protein YflT; Region: YflT; pfam11181 262543003721 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262543003722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262543003723 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 262543003724 putative uracil/xanthine transporter; Provisional; Region: PRK11412 262543003725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543003726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543003727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543003728 dimerization interface [polypeptide binding]; other site 262543003729 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 262543003730 hypothetical protein; Reviewed; Region: PRK09588 262543003731 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543003732 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543003733 Integrase core domain; Region: rve; pfam00665 262543003734 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 262543003735 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 262543003736 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 262543003737 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 262543003738 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543003739 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543003740 Integrase core domain; Region: rve; pfam00665 262543003741 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 262543003742 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262543003743 active site 262543003744 metal binding site [ion binding]; metal-binding site 262543003745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543003746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543003747 Isochorismatase family; Region: Isochorismatase; pfam00857 262543003748 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262543003749 catalytic triad [active] 262543003750 conserved cis-peptide bond; other site 262543003751 Predicted flavoprotein [General function prediction only]; Region: COG0431 262543003752 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262543003753 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 262543003754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543003755 Zn binding site [ion binding]; other site 262543003756 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 262543003757 Zn binding site [ion binding]; other site 262543003758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543003759 MarR family; Region: MarR; pfam01047 262543003760 MarR family; Region: MarR_2; cl17246 262543003761 Esterase/lipase [General function prediction only]; Region: COG1647 262543003762 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543003763 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 262543003764 active site 262543003765 NTP binding site [chemical binding]; other site 262543003766 metal binding triad [ion binding]; metal-binding site 262543003767 antibiotic binding site [chemical binding]; other site 262543003768 Haemolysin E (HlyE); Region: HlyE; cl11627 262543003769 aconitate hydratase; Validated; Region: PRK09277 262543003770 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 262543003771 substrate binding site [chemical binding]; other site 262543003772 ligand binding site [chemical binding]; other site 262543003773 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 262543003774 substrate binding site [chemical binding]; other site 262543003775 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 262543003776 stage V sporulation protein K; Region: spore_V_K; TIGR02881 262543003777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543003778 Walker A motif; other site 262543003779 ATP binding site [chemical binding]; other site 262543003780 Walker B motif; other site 262543003781 arginine finger; other site 262543003782 stage V sporulation protein K; Region: spore_V_K; TIGR02881 262543003783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543003784 Walker A motif; other site 262543003785 ATP binding site [chemical binding]; other site 262543003786 Walker B motif; other site 262543003787 arginine finger; other site 262543003788 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 262543003789 active site 262543003790 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 262543003791 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 262543003792 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 262543003793 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 262543003794 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 262543003795 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 262543003796 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 262543003797 Protein of unknown function (DUF975); Region: DUF975; cl10504 262543003798 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 262543003799 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262543003800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262543003801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262543003802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543003803 Walker A/P-loop; other site 262543003804 ATP binding site [chemical binding]; other site 262543003805 Q-loop/lid; other site 262543003806 ABC transporter signature motif; other site 262543003807 Walker B; other site 262543003808 D-loop; other site 262543003809 H-loop/switch region; other site 262543003810 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 262543003811 GAF domain; Region: GAF_3; pfam13492 262543003812 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 262543003813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543003814 dimer interface [polypeptide binding]; other site 262543003815 phosphorylation site [posttranslational modification] 262543003816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543003817 ATP binding site [chemical binding]; other site 262543003818 Mg2+ binding site [ion binding]; other site 262543003819 G-X-G motif; other site 262543003820 GAF domain; Region: GAF; pfam01590 262543003821 GAF domain; Region: GAF_2; pfam13185 262543003822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543003823 metal binding site [ion binding]; metal-binding site 262543003824 active site 262543003825 I-site; other site 262543003826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543003827 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 262543003828 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 262543003829 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 262543003830 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 262543003831 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 262543003832 Transposase IS200 like; Region: Y1_Tnp; pfam01797 262543003833 Probable transposase; Region: OrfB_IS605; pfam01385 262543003834 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543003835 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 262543003836 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 262543003837 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 262543003838 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 262543003839 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262543003840 active site 262543003841 dimer interface [polypeptide binding]; other site 262543003842 Predicted membrane protein [Function unknown]; Region: COG3766 262543003843 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 262543003844 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 262543003845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543003846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543003847 metal binding site [ion binding]; metal-binding site 262543003848 active site 262543003849 I-site; other site 262543003850 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 262543003851 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 262543003852 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 262543003853 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 262543003854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543003855 NAD(P) binding site [chemical binding]; other site 262543003856 active site 262543003857 putative acyltransferase; Provisional; Region: PRK05790 262543003858 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262543003859 dimer interface [polypeptide binding]; other site 262543003860 active site 262543003861 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262543003862 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 262543003863 Walker A/P-loop; other site 262543003864 ATP binding site [chemical binding]; other site 262543003865 Q-loop/lid; other site 262543003866 ABC transporter signature motif; other site 262543003867 Walker B; other site 262543003868 D-loop; other site 262543003869 H-loop/switch region; other site 262543003870 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 262543003871 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 262543003872 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 262543003873 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 262543003874 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 262543003875 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 262543003876 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 262543003877 dimer interface [polypeptide binding]; other site 262543003878 active site 262543003879 metal binding site [ion binding]; metal-binding site 262543003880 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 262543003881 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 262543003882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 262543003883 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 262543003884 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 262543003885 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003886 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543003887 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543003888 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543003889 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543003890 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543003891 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 262543003892 nudix motif; other site 262543003893 short chain dehydrogenase; Provisional; Region: PRK06701 262543003894 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 262543003895 NAD binding site [chemical binding]; other site 262543003896 metal binding site [ion binding]; metal-binding site 262543003897 active site 262543003898 Predicted transcriptional regulators [Transcription]; Region: COG1725 262543003899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543003900 DNA-binding site [nucleotide binding]; DNA binding site 262543003901 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262543003902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543003903 Walker A/P-loop; other site 262543003904 ATP binding site [chemical binding]; other site 262543003905 Q-loop/lid; other site 262543003906 ABC transporter signature motif; other site 262543003907 Walker B; other site 262543003908 D-loop; other site 262543003909 H-loop/switch region; other site 262543003910 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262543003911 NlpC/P60 family; Region: NLPC_P60; pfam00877 262543003912 MFS transport protein AraJ; Provisional; Region: PRK10091 262543003913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543003914 putative substrate translocation pore; other site 262543003915 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 262543003916 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 262543003917 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 262543003918 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 262543003919 thiamine phosphate binding site [chemical binding]; other site 262543003920 active site 262543003921 pyrophosphate binding site [ion binding]; other site 262543003922 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 262543003923 hydroxyglutarate oxidase; Provisional; Region: PRK11728 262543003924 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 262543003925 thiS-thiF/thiG interaction site; other site 262543003926 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 262543003927 ThiS interaction site; other site 262543003928 putative active site [active] 262543003929 tetramer interface [polypeptide binding]; other site 262543003930 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 262543003931 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 262543003932 ATP binding site [chemical binding]; other site 262543003933 substrate interface [chemical binding]; other site 262543003934 hypothetical protein; Provisional; Region: PRK07758 262543003935 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 262543003936 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 262543003937 active site 262543003938 metal binding site [ion binding]; metal-binding site 262543003939 DNA binding site [nucleotide binding] 262543003940 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 262543003941 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 262543003942 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 262543003943 Walker A/P-loop; other site 262543003944 ATP binding site [chemical binding]; other site 262543003945 Q-loop/lid; other site 262543003946 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 262543003947 ABC transporter signature motif; other site 262543003948 Walker B; other site 262543003949 D-loop; other site 262543003950 H-loop/switch region; other site 262543003951 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 262543003952 Bax inhibitor 1 like; Region: BaxI_1; cl17691 262543003953 Rrf2 family protein; Region: rrf2_super; TIGR00738 262543003954 Transcriptional regulator; Region: Rrf2; pfam02082 262543003955 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 262543003956 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 262543003957 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 262543003958 dimanganese center [ion binding]; other site 262543003959 Isochorismatase family; Region: Isochorismatase; pfam00857 262543003960 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262543003961 catalytic triad [active] 262543003962 conserved cis-peptide bond; other site 262543003963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543003964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543003965 dimer interface [polypeptide binding]; other site 262543003966 phosphorylation site [posttranslational modification] 262543003967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543003968 ATP binding site [chemical binding]; other site 262543003969 Mg2+ binding site [ion binding]; other site 262543003970 G-X-G motif; other site 262543003971 Rrf2 family protein; Region: rrf2_super; TIGR00738 262543003972 Transcriptional regulator; Region: Rrf2; pfam02082 262543003973 hypothetical protein; Provisional; Region: PRK06771 262543003974 Nuclease-related domain; Region: NERD; pfam08378 262543003975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543003976 MarR family; Region: MarR_2; pfam12802 262543003977 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 262543003978 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 262543003979 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 262543003980 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 262543003981 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262543003982 NAD(P) binding site [chemical binding]; other site 262543003983 putative active site [active] 262543003984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262543003985 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262543003986 substrate binding pocket [chemical binding]; other site 262543003987 membrane-bound complex binding site; other site 262543003988 hinge residues; other site 262543003989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543003990 Walker A/P-loop; other site 262543003991 ATP binding site [chemical binding]; other site 262543003992 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 262543003993 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262543003994 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543003995 Predicted permease [General function prediction only]; Region: COG2056 262543003996 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 262543003997 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 262543003998 active site clefts [active] 262543003999 zinc binding site [ion binding]; other site 262543004000 dimer interface [polypeptide binding]; other site 262543004001 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 262543004002 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 262543004003 putative catalytic cysteine [active] 262543004004 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 262543004005 putative active site [active] 262543004006 metal binding site [ion binding]; metal-binding site 262543004007 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 262543004008 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 262543004009 active site 262543004010 metal binding site [ion binding]; metal-binding site 262543004011 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 262543004012 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 262543004013 DinB family; Region: DinB; cl17821 262543004014 DinB superfamily; Region: DinB_2; pfam12867 262543004015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262543004016 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 262543004017 catalytic site [active] 262543004018 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262543004019 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 262543004020 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 262543004021 cardiolipin synthetase; Reviewed; Region: PRK12452 262543004022 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262543004023 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 262543004024 putative active site [active] 262543004025 catalytic site [active] 262543004026 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 262543004027 putative active site [active] 262543004028 catalytic site [active] 262543004029 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 262543004030 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 262543004031 putative active site [active] 262543004032 putative catalytic site [active] 262543004033 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 262543004034 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 262543004035 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262543004036 catalytic residue [active] 262543004037 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 262543004038 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 262543004039 Ion channel; Region: Ion_trans_2; pfam07885 262543004040 TrkA-N domain; Region: TrkA_N; pfam02254 262543004041 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262543004042 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 262543004043 active site 262543004044 catalytic residues [active] 262543004045 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 262543004046 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 262543004047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543004048 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 262543004049 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 262543004050 Protein of unknown function (DUF444); Region: DUF444; cl17371 262543004051 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 262543004052 EamA-like transporter family; Region: EamA; pfam00892 262543004053 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 262543004054 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 262543004055 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 262543004056 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 262543004057 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 262543004058 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 262543004059 catalytic residues [active] 262543004060 dimer interface [polypeptide binding]; other site 262543004061 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 262543004062 EamA-like transporter family; Region: EamA; pfam00892 262543004063 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 262543004064 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 262543004065 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 262543004066 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 262543004067 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 262543004068 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 262543004069 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 262543004070 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 262543004071 excinuclease ABC subunit A; Provisional; Region: PRK00635 262543004072 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543004073 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543004074 Integrase core domain; Region: rve; pfam00665 262543004075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543004076 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543004077 Probable transposase; Region: OrfB_IS605; pfam01385 262543004078 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 262543004079 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 262543004080 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 262543004081 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 262543004082 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 262543004083 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 262543004084 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 262543004085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543004086 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543004087 Probable transposase; Region: OrfB_IS605; pfam01385 262543004088 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543004089 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 262543004090 serine/threonine transporter SstT; Provisional; Region: PRK13628 262543004091 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 262543004092 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 262543004093 Predicted transcriptional regulators [Transcription]; Region: COG1733 262543004094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543004095 dimerization interface [polypeptide binding]; other site 262543004096 putative DNA binding site [nucleotide binding]; other site 262543004097 putative Zn2+ binding site [ion binding]; other site 262543004098 LysE type translocator; Region: LysE; cl00565 262543004099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543004100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543004101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543004102 dimerization interface [polypeptide binding]; other site 262543004103 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262543004104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262543004105 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 262543004106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543004107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543004108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543004109 N-acetylneuraminate lyase; Region: nanA; TIGR00683 262543004110 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 262543004111 inhibitor site; inhibition site 262543004112 active site 262543004113 dimer interface [polypeptide binding]; other site 262543004114 catalytic residue [active] 262543004115 Uncharacterized conserved protein [Function unknown]; Region: COG1359 262543004116 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 262543004117 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 262543004118 potential catalytic triad [active] 262543004119 conserved cys residue [active] 262543004120 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 262543004121 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 262543004122 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 262543004123 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 262543004124 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 262543004125 putative active site [active] 262543004126 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 262543004127 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543004128 active site turn [active] 262543004129 phosphorylation site [posttranslational modification] 262543004130 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543004131 Uncharacterized conserved protein [Function unknown]; Region: COG3589 262543004132 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 262543004133 topology modulation protein; Reviewed; Region: PRK08118 262543004134 AAA domain; Region: AAA_17; pfam13207 262543004135 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543004136 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262543004137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543004138 active site 262543004139 metal binding site [ion binding]; metal-binding site 262543004140 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 262543004141 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 262543004142 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 262543004143 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 262543004144 substrate binding site [chemical binding]; other site 262543004145 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 262543004146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543004147 dimer interface [polypeptide binding]; other site 262543004148 conserved gate region; other site 262543004149 putative PBP binding loops; other site 262543004150 ABC-ATPase subunit interface; other site 262543004151 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 262543004152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543004153 dimer interface [polypeptide binding]; other site 262543004154 conserved gate region; other site 262543004155 putative PBP binding loops; other site 262543004156 ABC-ATPase subunit interface; other site 262543004157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262543004158 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 262543004159 Walker A/P-loop; other site 262543004160 ATP binding site [chemical binding]; other site 262543004161 Q-loop/lid; other site 262543004162 ABC transporter signature motif; other site 262543004163 Walker B; other site 262543004164 D-loop; other site 262543004165 H-loop/switch region; other site 262543004166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262543004167 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 262543004168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262543004169 Walker A/P-loop; other site 262543004170 ATP binding site [chemical binding]; other site 262543004171 Q-loop/lid; other site 262543004172 ABC transporter signature motif; other site 262543004173 Walker B; other site 262543004174 D-loop; other site 262543004175 H-loop/switch region; other site 262543004176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543004177 non-specific DNA binding site [nucleotide binding]; other site 262543004178 salt bridge; other site 262543004179 sequence-specific DNA binding site [nucleotide binding]; other site 262543004180 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543004181 MarR family; Region: MarR_2; pfam12802 262543004182 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262543004183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543004184 MarR family; Region: MarR; pfam01047 262543004185 MarR family; Region: MarR_2; cl17246 262543004186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543004187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004188 Coenzyme A binding pocket [chemical binding]; other site 262543004189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004190 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262543004191 NAD(P) binding site [chemical binding]; other site 262543004192 active site 262543004193 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262543004194 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543004195 MarR family; Region: MarR_2; pfam12802 262543004196 DinB superfamily; Region: DinB_2; pfam12867 262543004197 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 262543004198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543004199 H+ Antiporter protein; Region: 2A0121; TIGR00900 262543004200 putative substrate translocation pore; other site 262543004201 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543004202 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262543004203 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 262543004204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543004205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543004206 metal binding site [ion binding]; metal-binding site 262543004207 active site 262543004208 I-site; other site 262543004209 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 262543004210 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 262543004211 Helix-turn-helix domain; Region: HTH_36; pfam13730 262543004212 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 262543004213 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 262543004214 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 262543004215 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 262543004216 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262543004217 Phage lysis protein, holin; Region: Phage_holin; pfam04688 262543004218 CHASE3 domain; Region: CHASE3; cl05000 262543004219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543004220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543004221 metal binding site [ion binding]; metal-binding site 262543004222 active site 262543004223 I-site; other site 262543004224 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262543004225 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 262543004226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543004227 catalytic residue [active] 262543004228 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 262543004229 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262543004230 DNA binding residues [nucleotide binding] 262543004231 putative dimer interface [polypeptide binding]; other site 262543004232 sepiapterin reductase; Region: sepiapter_red; TIGR01500 262543004233 classical (c) SDRs; Region: SDR_c; cd05233 262543004234 NAD(P) binding site [chemical binding]; other site 262543004235 active site 262543004236 H+ Antiporter protein; Region: 2A0121; TIGR00900 262543004237 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 262543004238 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 262543004239 heme-binding site [chemical binding]; other site 262543004240 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 262543004241 FAD binding pocket [chemical binding]; other site 262543004242 FAD binding motif [chemical binding]; other site 262543004243 phosphate binding motif [ion binding]; other site 262543004244 beta-alpha-beta structure motif; other site 262543004245 NAD binding pocket [chemical binding]; other site 262543004246 Heme binding pocket [chemical binding]; other site 262543004247 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 262543004248 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 262543004249 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262543004250 RRXRR protein; Region: RRXRR; pfam14239 262543004251 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262543004252 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 262543004253 active site 262543004254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543004256 Transcriptional regulators [Transcription]; Region: GntR; COG1802 262543004257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543004258 DNA-binding site [nucleotide binding]; DNA binding site 262543004259 FCD domain; Region: FCD; pfam07729 262543004260 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 262543004261 Protein of unknown function (DUF554); Region: DUF554; pfam04474 262543004262 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 262543004263 putative active site [active] 262543004264 nucleotide binding site [chemical binding]; other site 262543004265 nudix motif; other site 262543004266 putative metal binding site [ion binding]; other site 262543004267 N-acetyltransferase; Region: Acetyltransf_2; cl00949 262543004268 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 262543004269 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 262543004270 siderophore binding site; other site 262543004271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543004272 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 262543004273 ABC-ATPase subunit interface; other site 262543004274 dimer interface [polypeptide binding]; other site 262543004275 putative PBP binding regions; other site 262543004276 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 262543004277 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543004278 ABC-ATPase subunit interface; other site 262543004279 dimer interface [polypeptide binding]; other site 262543004280 putative PBP binding regions; other site 262543004281 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262543004282 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 262543004283 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543004284 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543004285 metal binding site [ion binding]; metal-binding site 262543004286 active site 262543004287 I-site; other site 262543004288 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 262543004289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543004290 putative metal binding site [ion binding]; other site 262543004291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543004292 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 262543004293 putative substrate translocation pore; other site 262543004294 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262543004295 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 262543004296 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 262543004297 active site pocket [active] 262543004298 oxyanion hole [active] 262543004299 catalytic triad [active] 262543004300 active site nucleophile [active] 262543004301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 262543004302 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 262543004303 Fic family protein [Function unknown]; Region: COG3177 262543004304 Fic/DOC family; Region: Fic; pfam02661 262543004305 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 262543004306 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262543004307 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 262543004308 putative active site [active] 262543004309 catalytic site [active] 262543004310 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 262543004311 putative active site [active] 262543004312 catalytic site [active] 262543004313 Domain of unknown function DUF20; Region: UPF0118; pfam01594 262543004314 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 262543004315 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543004316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543004317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004318 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 262543004319 Coenzyme A binding pocket [chemical binding]; other site 262543004320 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 262543004321 active site 262543004322 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 262543004323 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 262543004324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543004325 dimerization interface [polypeptide binding]; other site 262543004326 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543004327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543004328 dimer interface [polypeptide binding]; other site 262543004329 putative CheW interface [polypeptide binding]; other site 262543004330 MerC mercury resistance protein; Region: MerC; cl03934 262543004331 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 262543004332 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 262543004333 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543004334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004335 Coenzyme A binding pocket [chemical binding]; other site 262543004336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543004337 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 262543004338 putative dimer interface [polypeptide binding]; other site 262543004339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543004340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543004341 dimerization interface [polypeptide binding]; other site 262543004342 putative DNA binding site [nucleotide binding]; other site 262543004343 putative Zn2+ binding site [ion binding]; other site 262543004344 arsenical pump membrane protein; Provisional; Region: PRK15445 262543004345 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 262543004346 transmembrane helices; other site 262543004347 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 262543004348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543004349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543004350 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543004351 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 262543004352 active site residue [active] 262543004353 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 262543004354 YusW-like protein; Region: YusW; pfam14039 262543004355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 262543004356 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543004357 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543004358 Winged helix-turn helix; Region: HTH_29; pfam13551 262543004359 putative transposase OrfB; Reviewed; Region: PHA02517 262543004360 HTH-like domain; Region: HTH_21; pfam13276 262543004361 Integrase core domain; Region: rve; pfam00665 262543004362 Integrase core domain; Region: rve_3; pfam13683 262543004363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543004364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004365 Coenzyme A binding pocket [chemical binding]; other site 262543004366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543004367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543004368 non-specific DNA binding site [nucleotide binding]; other site 262543004369 salt bridge; other site 262543004370 sequence-specific DNA binding site [nucleotide binding]; other site 262543004371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543004372 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543004373 Probable transposase; Region: OrfB_IS605; pfam01385 262543004374 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543004375 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 262543004376 nudix motif; other site 262543004377 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262543004378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543004379 motif I; other site 262543004380 active site 262543004381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543004382 putative substrate translocation pore; other site 262543004383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543004384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262543004385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543004386 proline/glycine betaine transporter; Provisional; Region: PRK10642 262543004387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543004388 putative substrate translocation pore; other site 262543004389 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262543004390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543004391 DNA-binding site [nucleotide binding]; DNA binding site 262543004392 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 262543004393 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 262543004394 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543004395 active site turn [active] 262543004396 phosphorylation site [posttranslational modification] 262543004397 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543004398 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 262543004399 HPr interaction site; other site 262543004400 glycerol kinase (GK) interaction site [polypeptide binding]; other site 262543004401 active site 262543004402 phosphorylation site [posttranslational modification] 262543004403 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 262543004404 beta-galactosidase; Region: BGL; TIGR03356 262543004405 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 262543004406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 262543004407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543004408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543004409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543004410 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 262543004411 catalytic triad [active] 262543004412 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 262543004413 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 262543004414 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 262543004415 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 262543004416 TrkA-C domain; Region: TrkA_C; pfam02080 262543004417 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 262543004418 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 262543004419 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543004420 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 262543004421 putative NAD(P) binding site [chemical binding]; other site 262543004422 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 262543004423 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 262543004424 folate binding site [chemical binding]; other site 262543004425 NADP+ binding site [chemical binding]; other site 262543004426 Predicted transcriptional regulator [Transcription]; Region: COG2378 262543004427 HTH domain; Region: HTH_11; pfam08279 262543004428 WYL domain; Region: WYL; pfam13280 262543004429 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 262543004430 succinic semialdehyde dehydrogenase; Region: PLN02278 262543004431 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 262543004432 tetramerization interface [polypeptide binding]; other site 262543004433 NAD(P) binding site [chemical binding]; other site 262543004434 catalytic residues [active] 262543004435 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 262543004436 Phosphotransferase enzyme family; Region: APH; pfam01636 262543004437 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262543004438 active site 262543004439 ATP binding site [chemical binding]; other site 262543004440 short chain dehydrogenase; Provisional; Region: PRK08303 262543004441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004442 NAD(P) binding site [chemical binding]; other site 262543004443 active site 262543004444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004445 tropinone reductase; Provisional; Region: PRK09242 262543004446 NAD(P) binding site [chemical binding]; other site 262543004447 active site 262543004448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543004449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543004450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543004451 dimerization interface [polypeptide binding]; other site 262543004452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543004453 dimerization interface [polypeptide binding]; other site 262543004454 putative DNA binding site [nucleotide binding]; other site 262543004455 putative Zn2+ binding site [ion binding]; other site 262543004456 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 262543004457 heme-binding site [chemical binding]; other site 262543004458 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543004459 dimer interface [polypeptide binding]; other site 262543004460 putative CheW interface [polypeptide binding]; other site 262543004461 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 262543004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004463 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 262543004464 NAD(P) binding site [chemical binding]; other site 262543004465 active site 262543004466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543004467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543004468 putative substrate translocation pore; other site 262543004469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543004470 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262543004471 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543004472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004473 Coenzyme A binding pocket [chemical binding]; other site 262543004474 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 262543004475 nudix motif; other site 262543004476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543004477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004478 Coenzyme A binding pocket [chemical binding]; other site 262543004479 YCII-related domain; Region: YCII; cl00999 262543004480 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262543004481 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 262543004482 Walker A/P-loop; other site 262543004483 ATP binding site [chemical binding]; other site 262543004484 Q-loop/lid; other site 262543004485 ABC transporter signature motif; other site 262543004486 Walker B; other site 262543004487 D-loop; other site 262543004488 H-loop/switch region; other site 262543004489 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 262543004490 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262543004491 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543004492 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543004493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 262543004494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 262543004495 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 262543004496 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 262543004497 FtsX-like permease family; Region: FtsX; pfam02687 262543004498 FtsX-like permease family; Region: FtsX; pfam02687 262543004499 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 262543004500 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 262543004501 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543004502 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262543004503 active site 262543004504 metal binding site [ion binding]; metal-binding site 262543004505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543004506 dimerization interface [polypeptide binding]; other site 262543004507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543004508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543004509 dimer interface [polypeptide binding]; other site 262543004510 putative CheW interface [polypeptide binding]; other site 262543004511 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 262543004512 DinB superfamily; Region: DinB_2; pfam12867 262543004513 Right handed beta helix region; Region: Beta_helix; pfam13229 262543004514 PspC domain; Region: PspC; pfam04024 262543004515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262543004516 active site 262543004517 metal binding site [ion binding]; metal-binding site 262543004518 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543004519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543004520 PAS domain; Region: PAS_9; pfam13426 262543004521 putative active site [active] 262543004522 heme pocket [chemical binding]; other site 262543004523 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 262543004524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543004525 dimer interface [polypeptide binding]; other site 262543004526 putative CheW interface [polypeptide binding]; other site 262543004527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543004528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004529 Coenzyme A binding pocket [chemical binding]; other site 262543004530 H+ Antiporter protein; Region: 2A0121; TIGR00900 262543004531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543004532 dimerization interface [polypeptide binding]; other site 262543004533 putative DNA binding site [nucleotide binding]; other site 262543004534 putative Zn2+ binding site [ion binding]; other site 262543004535 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 262543004536 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 262543004537 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 262543004538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543004539 putative DNA binding site [nucleotide binding]; other site 262543004540 putative Zn2+ binding site [ion binding]; other site 262543004541 AsnC family; Region: AsnC_trans_reg; pfam01037 262543004542 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 262543004543 Peptidase family M50; Region: Peptidase_M50; pfam02163 262543004544 active site 262543004545 putative substrate binding region [chemical binding]; other site 262543004546 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543004547 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262543004548 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 262543004549 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 262543004550 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543004551 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 262543004552 putative NAD(P) binding site [chemical binding]; other site 262543004553 Phosphotransferase enzyme family; Region: APH; pfam01636 262543004554 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 262543004555 active site 262543004556 ATP binding site [chemical binding]; other site 262543004557 AAA domain; Region: AAA_17; cl17253 262543004558 Ion channel; Region: Ion_trans_2; pfam07885 262543004559 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 262543004560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543004561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543004562 DNA binding residues [nucleotide binding] 262543004563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543004564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004565 Coenzyme A binding pocket [chemical binding]; other site 262543004566 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 262543004567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543004568 motif II; other site 262543004569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262543004570 PGAP1-like protein; Region: PGAP1; pfam07819 262543004571 PAS fold; Region: PAS_3; pfam08447 262543004572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543004573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543004574 metal binding site [ion binding]; metal-binding site 262543004575 active site 262543004576 I-site; other site 262543004577 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262543004578 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262543004579 Walker A/P-loop; other site 262543004580 ATP binding site [chemical binding]; other site 262543004581 Q-loop/lid; other site 262543004582 ABC transporter signature motif; other site 262543004583 Walker B; other site 262543004584 D-loop; other site 262543004585 H-loop/switch region; other site 262543004586 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262543004587 hypothetical protein; Provisional; Region: PRK06474 262543004588 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 262543004589 multiple promoter invertase; Provisional; Region: mpi; PRK13413 262543004590 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 262543004591 catalytic residues [active] 262543004592 catalytic nucleophile [active] 262543004593 Presynaptic Site I dimer interface [polypeptide binding]; other site 262543004594 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 262543004595 Synaptic Flat tetramer interface [polypeptide binding]; other site 262543004596 Synaptic Site I dimer interface [polypeptide binding]; other site 262543004597 DNA binding site [nucleotide binding] 262543004598 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 262543004599 DNA-binding interface [nucleotide binding]; DNA binding site 262543004600 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 262543004601 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262543004602 NAD binding site [chemical binding]; other site 262543004603 substrate binding site [chemical binding]; other site 262543004604 putative active site [active] 262543004605 Predicted transcriptional regulator [Transcription]; Region: COG1959 262543004606 Transcriptional regulator; Region: Rrf2; pfam02082 262543004607 Transcriptional regulator; Region: Rrf2; cl17282 262543004608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262543004609 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262543004610 Walker A/P-loop; other site 262543004611 ATP binding site [chemical binding]; other site 262543004612 Q-loop/lid; other site 262543004613 ABC transporter signature motif; other site 262543004614 Walker B; other site 262543004615 D-loop; other site 262543004616 H-loop/switch region; other site 262543004617 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 262543004618 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262543004619 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 262543004620 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 262543004621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004622 NAD(P) binding site [chemical binding]; other site 262543004623 active site 262543004624 Asp23 family; Region: Asp23; pfam03780 262543004625 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 262543004626 Asp23 family; Region: Asp23; pfam03780 262543004627 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262543004628 classical (c) SDRs; Region: SDR_c; cd05233 262543004629 NAD(P) binding site [chemical binding]; other site 262543004630 active site 262543004631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543004632 PAS domain; Region: PAS_9; pfam13426 262543004633 putative active site [active] 262543004634 heme pocket [chemical binding]; other site 262543004635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543004636 dimer interface [polypeptide binding]; other site 262543004637 putative CheW interface [polypeptide binding]; other site 262543004638 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 262543004639 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 262543004640 active site 262543004641 NTP binding site [chemical binding]; other site 262543004642 metal binding triad [ion binding]; metal-binding site 262543004643 antibiotic binding site [chemical binding]; other site 262543004644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004645 Coenzyme A binding pocket [chemical binding]; other site 262543004646 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262543004647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543004648 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543004649 Probable transposase; Region: OrfB_IS605; pfam01385 262543004650 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543004651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262543004652 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 262543004653 TAP-like protein; Region: Abhydrolase_4; pfam08386 262543004654 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 262543004655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543004656 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 262543004657 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262543004658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262543004659 Walker A/P-loop; other site 262543004660 ATP binding site [chemical binding]; other site 262543004661 Q-loop/lid; other site 262543004662 ABC transporter signature motif; other site 262543004663 Walker B; other site 262543004664 D-loop; other site 262543004665 H-loop/switch region; other site 262543004666 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262543004667 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262543004668 Walker A/P-loop; other site 262543004669 ATP binding site [chemical binding]; other site 262543004670 Q-loop/lid; other site 262543004671 ABC transporter signature motif; other site 262543004672 Walker B; other site 262543004673 D-loop; other site 262543004674 H-loop/switch region; other site 262543004675 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 262543004676 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 262543004677 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 262543004678 5S rRNA interface [nucleotide binding]; other site 262543004679 CTC domain interface [polypeptide binding]; other site 262543004680 L16 interface [polypeptide binding]; other site 262543004681 SWIM zinc finger; Region: SWIM; pfam04434 262543004682 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 262543004683 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 262543004684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543004685 ATP binding site [chemical binding]; other site 262543004686 putative Mg++ binding site [ion binding]; other site 262543004687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543004688 nucleotide binding region [chemical binding]; other site 262543004689 ATP-binding site [chemical binding]; other site 262543004690 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 262543004691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262543004692 active site 262543004693 DNA binding site [nucleotide binding] 262543004694 Int/Topo IB signature motif; other site 262543004695 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 262543004696 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 262543004697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543004698 ATP binding site [chemical binding]; other site 262543004699 Mg2+ binding site [ion binding]; other site 262543004700 G-X-G motif; other site 262543004701 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 262543004702 anchoring element; other site 262543004703 dimer interface [polypeptide binding]; other site 262543004704 ATP binding site [chemical binding]; other site 262543004705 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 262543004706 active site 262543004707 putative metal-binding site [ion binding]; other site 262543004708 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 262543004709 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 262543004710 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 262543004711 CAP-like domain; other site 262543004712 active site 262543004713 primary dimer interface [polypeptide binding]; other site 262543004714 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543004715 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262543004716 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 262543004717 nudix motif; other site 262543004718 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 262543004719 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262543004720 catalytic core [active] 262543004721 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 262543004722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 262543004723 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 262543004724 MoxR-like ATPases [General function prediction only]; Region: COG0714 262543004725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543004726 Walker A motif; other site 262543004727 ATP binding site [chemical binding]; other site 262543004728 Walker B motif; other site 262543004729 arginine finger; other site 262543004730 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262543004731 Protein of unknown function DUF58; Region: DUF58; pfam01882 262543004732 Predicted transcriptional regulator [Transcription]; Region: COG2378 262543004733 WYL domain; Region: WYL; pfam13280 262543004734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262543004735 Heat induced stress protein YflT; Region: YflT; pfam11181 262543004736 Iron permease FTR1 family; Region: FTR1; cl00475 262543004737 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 262543004738 Imelysin; Region: Peptidase_M75; pfam09375 262543004739 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 262543004740 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543004741 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543004742 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 262543004743 putative active site [active] 262543004744 putative oxidoreductase; Provisional; Region: PRK10206 262543004745 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262543004746 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 262543004747 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 262543004748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543004749 Coenzyme A binding pocket [chemical binding]; other site 262543004750 short chain dehydrogenase; Provisional; Region: PRK06197 262543004751 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262543004752 putative NAD(P) binding site [chemical binding]; other site 262543004753 active site 262543004754 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 262543004755 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 262543004756 TrkA-C domain; Region: TrkA_C; pfam02080 262543004757 Protein phosphatase 2C; Region: PP2C_2; pfam13672 262543004758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543004759 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262543004760 Predicted membrane protein [Function unknown]; Region: COG3428 262543004761 Bacterial PH domain; Region: DUF304; pfam03703 262543004762 Bacterial PH domain; Region: DUF304; pfam03703 262543004763 Uncharacterized conserved protein [Function unknown]; Region: COG3402 262543004764 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543004765 MarR family; Region: MarR; pfam01047 262543004766 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 262543004767 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 262543004768 synthetase active site [active] 262543004769 NTP binding site [chemical binding]; other site 262543004770 metal binding site [ion binding]; metal-binding site 262543004771 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543004772 MarR family; Region: MarR; pfam01047 262543004773 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543004774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543004775 TPR motif; other site 262543004776 Tetratrico peptide repeat; Region: TPR_5; pfam12688 262543004777 binding surface 262543004778 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262543004779 active site 262543004780 ATP binding site [chemical binding]; other site 262543004781 Phosphotransferase enzyme family; Region: APH; pfam01636 262543004782 substrate binding site [chemical binding]; other site 262543004783 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 262543004784 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 262543004785 catalytic site [active] 262543004786 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 262543004787 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 262543004788 active site 262543004789 catalytic site [active] 262543004790 metal binding site [ion binding]; metal-binding site 262543004791 dimer interface [polypeptide binding]; other site 262543004792 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 262543004793 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 262543004794 active site 262543004795 Zn binding site [ion binding]; other site 262543004796 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262543004797 active site 262543004798 substrate binding site [chemical binding]; other site 262543004799 ATP binding site [chemical binding]; other site 262543004800 Transposase IS200 like; Region: Y1_Tnp; pfam01797 262543004801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543004802 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543004803 Probable transposase; Region: OrfB_IS605; pfam01385 262543004804 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543004805 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 262543004806 pentamer interface [polypeptide binding]; other site 262543004807 dodecaamer interface [polypeptide binding]; other site 262543004808 YCII-related domain; Region: YCII; cl00999 262543004809 Creatinine amidohydrolase; Region: Creatininase; pfam02633 262543004810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262543004811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543004812 S-adenosylmethionine binding site [chemical binding]; other site 262543004813 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262543004814 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 262543004815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543004816 motif II; other site 262543004817 Protein of unknown function (DUF402); Region: DUF402; cl00979 262543004818 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 262543004819 classical (c) SDRs; Region: SDR_c; cd05233 262543004820 NAD(P) binding site [chemical binding]; other site 262543004821 active site 262543004822 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 262543004823 nudix motif; other site 262543004824 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 262543004825 Uncharacterized conserved protein [Function unknown]; Region: COG4925 262543004826 maltose O-acetyltransferase; Provisional; Region: PRK10092 262543004827 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 262543004828 active site 262543004829 substrate binding site [chemical binding]; other site 262543004830 trimer interface [polypeptide binding]; other site 262543004831 CoA binding site [chemical binding]; other site 262543004832 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 262543004833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004834 NAD(P) binding site [chemical binding]; other site 262543004835 active site 262543004836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543004837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543004838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543004839 dimerization interface [polypeptide binding]; other site 262543004840 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 262543004841 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 262543004842 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 262543004843 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 262543004844 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262543004845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543004846 dimer interface [polypeptide binding]; other site 262543004847 conserved gate region; other site 262543004848 putative PBP binding loops; other site 262543004849 ABC-ATPase subunit interface; other site 262543004850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543004851 dimer interface [polypeptide binding]; other site 262543004852 conserved gate region; other site 262543004853 ABC-ATPase subunit interface; other site 262543004854 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 262543004855 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262543004856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262543004857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262543004858 DNA binding site [nucleotide binding] 262543004859 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 262543004860 putative dimerization interface [polypeptide binding]; other site 262543004861 putative ligand binding site [chemical binding]; other site 262543004862 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 262543004863 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 262543004864 active site 262543004865 catalytic residues [active] 262543004866 RDD family; Region: RDD; pfam06271 262543004867 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 262543004868 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 262543004869 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 262543004870 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 262543004871 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262543004872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543004873 NAD(P) binding site [chemical binding]; other site 262543004874 active site 262543004875 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 262543004876 Dynamin family; Region: Dynamin_N; pfam00350 262543004877 G1 box; other site 262543004878 GTP/Mg2+ binding site [chemical binding]; other site 262543004879 G2 box; other site 262543004880 Switch I region; other site 262543004881 G3 box; other site 262543004882 Switch II region; other site 262543004883 G4 box; other site 262543004884 G5 box; other site 262543004885 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 262543004886 Dynamin family; Region: Dynamin_N; pfam00350 262543004887 G1 box; other site 262543004888 GTP/Mg2+ binding site [chemical binding]; other site 262543004889 G2 box; other site 262543004890 Switch I region; other site 262543004891 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 262543004892 G3 box; other site 262543004893 Switch II region; other site 262543004894 GTP/Mg2+ binding site [chemical binding]; other site 262543004895 G4 box; other site 262543004896 G5 box; other site 262543004897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543004898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543004899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543004900 dimerization interface [polypeptide binding]; other site 262543004901 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 262543004902 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 262543004903 oligomer interface [polypeptide binding]; other site 262543004904 metal binding site [ion binding]; metal-binding site 262543004905 metal binding site [ion binding]; metal-binding site 262543004906 putative Cl binding site [ion binding]; other site 262543004907 aspartate ring; other site 262543004908 basic sphincter; other site 262543004909 hydrophobic gate; other site 262543004910 periplasmic entrance; other site 262543004911 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262543004912 hydroxyglutarate oxidase; Provisional; Region: PRK11728 262543004913 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 262543004914 putative tRNA-binding site [nucleotide binding]; other site 262543004915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 262543004916 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543004917 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543004918 Winged helix-turn helix; Region: HTH_29; pfam13551 262543004919 putative transposase OrfB; Reviewed; Region: PHA02517 262543004920 HTH-like domain; Region: HTH_21; pfam13276 262543004921 Integrase core domain; Region: rve; pfam00665 262543004922 Integrase core domain; Region: rve_3; pfam13683 262543004923 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 262543004924 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 262543004925 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 262543004926 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 262543004927 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 262543004928 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 262543004929 active site 262543004930 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543004932 RNA polymerase sigma factor; Provisional; Region: PRK12515 262543004933 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262543004934 DNA-binding site [nucleotide binding]; DNA binding site 262543004935 RNA-binding motif; other site 262543004936 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262543004937 DNA-binding site [nucleotide binding]; DNA binding site 262543004938 RNA-binding motif; other site 262543004939 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262543004940 DNA-binding site [nucleotide binding]; DNA binding site 262543004941 RNA-binding motif; other site 262543004942 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262543004943 DNA-binding site [nucleotide binding]; DNA binding site 262543004944 RNA-binding motif; other site 262543004945 SnoaL-like domain; Region: SnoaL_3; pfam13474 262543004946 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 262543004947 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543004948 catalytic residue [active] 262543004949 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 262543004950 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 262543004951 putative ligand binding site [chemical binding]; other site 262543004952 putative NAD binding site [chemical binding]; other site 262543004953 putative catalytic site [active] 262543004954 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 262543004955 L-serine binding site [chemical binding]; other site 262543004956 ACT domain interface; other site 262543004957 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 262543004958 Uncharacterized conserved protein [Function unknown]; Region: COG4198 262543004959 maltodextrin glucosidase; Provisional; Region: PRK10785 262543004960 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 262543004961 homodimer interface [polypeptide binding]; other site 262543004962 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 262543004963 active site 262543004964 homodimer interface [polypeptide binding]; other site 262543004965 catalytic site [active] 262543004966 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 262543004967 hypothetical protein; Provisional; Region: PRK12378 262543004968 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 262543004969 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 262543004970 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 262543004971 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 262543004972 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 262543004973 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 262543004974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 262543004975 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 262543004976 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 262543004977 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 262543004978 Transcriptional regulator; Region: Rrf2; cl17282 262543004979 Rrf2 family protein; Region: rrf2_super; TIGR00738 262543004980 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 262543004981 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 262543004982 active site 262543004983 catalytic site [active] 262543004984 metal binding site [ion binding]; metal-binding site 262543004985 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262543004986 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 262543004987 E3 interaction surface; other site 262543004988 lipoyl attachment site [posttranslational modification]; other site 262543004989 e3 binding domain; Region: E3_binding; pfam02817 262543004990 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262543004991 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 262543004992 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 262543004993 TPP-binding site [chemical binding]; other site 262543004994 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 262543004995 dimer interface [polypeptide binding]; other site 262543004996 PYR/PP interface [polypeptide binding]; other site 262543004997 TPP binding site [chemical binding]; other site 262543004998 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262543004999 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 262543005000 Walker A/P-loop; other site 262543005001 ATP binding site [chemical binding]; other site 262543005002 Q-loop/lid; other site 262543005003 ABC transporter signature motif; other site 262543005004 Walker B; other site 262543005005 D-loop; other site 262543005006 H-loop/switch region; other site 262543005007 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 262543005008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543005009 dimer interface [polypeptide binding]; other site 262543005010 conserved gate region; other site 262543005011 putative PBP binding loops; other site 262543005012 ABC-ATPase subunit interface; other site 262543005013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262543005014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262543005015 substrate binding pocket [chemical binding]; other site 262543005016 membrane-bound complex binding site; other site 262543005017 hinge residues; other site 262543005018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543005019 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262543005020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262543005021 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 262543005022 putative dimer interface [polypeptide binding]; other site 262543005023 catalytic triad [active] 262543005024 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262543005025 catalytic residues [active] 262543005026 Protein of unknown function (DUF779); Region: DUF779; pfam05610 262543005027 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 262543005028 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262543005029 NAD(P) binding site [chemical binding]; other site 262543005030 catalytic residues [active] 262543005031 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 262543005032 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 262543005033 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262543005034 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262543005035 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 262543005036 active site 262543005037 phosphorylation site [posttranslational modification] 262543005038 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 262543005039 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 262543005040 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 262543005041 active site 262543005042 P-loop; other site 262543005043 phosphorylation site [posttranslational modification] 262543005044 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 262543005045 active site 262543005046 P-loop; other site 262543005047 phosphorylation site [posttranslational modification] 262543005048 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 262543005049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543005050 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 262543005051 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 262543005052 active site 262543005053 dimer interface [polypeptide binding]; other site 262543005054 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 262543005055 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 262543005056 active site 262543005057 FMN binding site [chemical binding]; other site 262543005058 substrate binding site [chemical binding]; other site 262543005059 3Fe-4S cluster binding site [ion binding]; other site 262543005060 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 262543005061 domain interface; other site 262543005062 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262543005063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262543005064 substrate binding pocket [chemical binding]; other site 262543005065 membrane-bound complex binding site; other site 262543005066 hinge residues; other site 262543005067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543005068 dimer interface [polypeptide binding]; other site 262543005069 conserved gate region; other site 262543005070 putative PBP binding loops; other site 262543005071 ABC-ATPase subunit interface; other site 262543005072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543005073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543005074 metal binding site [ion binding]; metal-binding site 262543005075 active site 262543005076 I-site; other site 262543005077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543005078 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262543005079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543005080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543005081 non-specific DNA binding site [nucleotide binding]; other site 262543005082 salt bridge; other site 262543005083 sequence-specific DNA binding site [nucleotide binding]; other site 262543005084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543005085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543005086 non-specific DNA binding site [nucleotide binding]; other site 262543005087 salt bridge; other site 262543005088 sequence-specific DNA binding site [nucleotide binding]; other site 262543005089 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 262543005090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262543005091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543005092 homodimer interface [polypeptide binding]; other site 262543005093 catalytic residue [active] 262543005094 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 262543005095 Na binding site [ion binding]; other site 262543005096 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 262543005097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543005098 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 262543005099 PilZ domain; Region: PilZ; pfam07238 262543005100 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 262543005101 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 262543005102 Ca binding site [ion binding]; other site 262543005103 active site 262543005104 catalytic site [active] 262543005105 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 262543005106 thymidylate synthase; Reviewed; Region: thyA; PRK01827 262543005107 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 262543005108 dimerization interface [polypeptide binding]; other site 262543005109 active site 262543005110 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 262543005111 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 262543005112 folate binding site [chemical binding]; other site 262543005113 NADP+ binding site [chemical binding]; other site 262543005114 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543005115 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543005116 metal binding site [ion binding]; metal-binding site 262543005117 active site 262543005118 I-site; other site 262543005119 fumarate hydratase; Reviewed; Region: fumC; PRK00485 262543005120 Class II fumarases; Region: Fumarase_classII; cd01362 262543005121 active site 262543005122 tetramer interface [polypeptide binding]; other site 262543005123 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262543005124 Domain of unknown function DUF21; Region: DUF21; pfam01595 262543005125 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262543005126 Transporter associated domain; Region: CorC_HlyC; smart01091 262543005127 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 262543005128 RNA/DNA hybrid binding site [nucleotide binding]; other site 262543005129 active site 262543005130 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262543005131 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262543005132 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 262543005133 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 262543005134 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 262543005135 generic binding surface II; other site 262543005136 generic binding surface I; other site 262543005137 HD domain; Region: HD; pfam01966 262543005138 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 262543005139 active site 262543005140 Zn binding site [ion binding]; other site 262543005141 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 262543005142 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 262543005143 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 262543005144 Na2 binding site [ion binding]; other site 262543005145 putative substrate binding site 1 [chemical binding]; other site 262543005146 Na binding site 1 [ion binding]; other site 262543005147 putative substrate binding site 2 [chemical binding]; other site 262543005148 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 262543005149 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 262543005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543005151 dimer interface [polypeptide binding]; other site 262543005152 conserved gate region; other site 262543005153 ABC-ATPase subunit interface; other site 262543005154 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 262543005155 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 262543005156 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262543005157 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 262543005158 Walker A/P-loop; other site 262543005159 ATP binding site [chemical binding]; other site 262543005160 Q-loop/lid; other site 262543005161 ABC transporter signature motif; other site 262543005162 Walker B; other site 262543005163 D-loop; other site 262543005164 H-loop/switch region; other site 262543005165 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 262543005166 putative active site [active] 262543005167 putative CoA binding site [chemical binding]; other site 262543005168 nudix motif; other site 262543005169 metal binding site [ion binding]; metal-binding site 262543005170 YvfG protein; Region: YvfG; pfam09628 262543005171 hypothetical protein; Provisional; Region: PRK06184 262543005172 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262543005173 cell division protein GpsB; Provisional; Region: PRK14127 262543005174 DivIVA domain; Region: DivI1A_domain; TIGR03544 262543005175 hypothetical protein; Provisional; Region: PRK13660 262543005176 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 262543005177 RNase_H superfamily; Region: RNase_H_2; pfam13482 262543005178 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 262543005179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543005180 ATP binding site [chemical binding]; other site 262543005181 putative Mg++ binding site [ion binding]; other site 262543005182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543005183 nucleotide binding region [chemical binding]; other site 262543005184 ATP-binding site [chemical binding]; other site 262543005185 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 262543005186 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 262543005187 Transglycosylase; Region: Transgly; pfam00912 262543005188 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 262543005189 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 262543005190 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 262543005191 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 262543005192 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 262543005193 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262543005194 minor groove reading motif; other site 262543005195 helix-hairpin-helix signature motif; other site 262543005196 substrate binding pocket [chemical binding]; other site 262543005197 active site 262543005198 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 262543005199 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 262543005200 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 262543005201 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 262543005202 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 262543005203 putative dimer interface [polypeptide binding]; other site 262543005204 putative anticodon binding site; other site 262543005205 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 262543005206 homodimer interface [polypeptide binding]; other site 262543005207 motif 1; other site 262543005208 motif 2; other site 262543005209 active site 262543005210 motif 3; other site 262543005211 aspartate aminotransferase; Provisional; Region: PRK05764 262543005212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262543005213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543005214 homodimer interface [polypeptide binding]; other site 262543005215 catalytic residue [active] 262543005216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 262543005217 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 262543005218 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 262543005219 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262543005220 active site 262543005221 catalytic site [active] 262543005222 substrate binding site [chemical binding]; other site 262543005223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 262543005224 ATP binding site [chemical binding]; other site 262543005225 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 262543005226 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 262543005227 tetramerization interface [polypeptide binding]; other site 262543005228 active site 262543005229 pantoate--beta-alanine ligase; Region: panC; TIGR00018 262543005230 Pantoate-beta-alanine ligase; Region: PanC; cd00560 262543005231 active site 262543005232 ATP-binding site [chemical binding]; other site 262543005233 pantoate-binding site; other site 262543005234 HXXH motif; other site 262543005235 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 262543005236 active site 262543005237 oligomerization interface [polypeptide binding]; other site 262543005238 metal binding site [ion binding]; metal-binding site 262543005239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543005240 putative DNA binding site [nucleotide binding]; other site 262543005241 putative Zn2+ binding site [ion binding]; other site 262543005242 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 262543005243 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 262543005244 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 262543005245 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 262543005246 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 262543005247 active site 262543005248 NTP binding site [chemical binding]; other site 262543005249 metal binding triad [ion binding]; metal-binding site 262543005250 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 262543005251 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 262543005252 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 262543005253 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 262543005254 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543005255 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543005256 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543005257 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 262543005258 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 262543005259 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 262543005260 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 262543005261 cytochrome b6; Provisional; Region: PRK03735 262543005262 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 262543005263 interchain domain interface [polypeptide binding]; other site 262543005264 intrachain domain interface; other site 262543005265 heme bH binding site [chemical binding]; other site 262543005266 Qi binding site; other site 262543005267 heme bL binding site [chemical binding]; other site 262543005268 Qo binding site; other site 262543005269 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 262543005270 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 262543005271 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 262543005272 iron-sulfur cluster [ion binding]; other site 262543005273 [2Fe-2S] cluster binding site [ion binding]; other site 262543005274 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 262543005275 hypothetical protein; Provisional; Region: PRK03636 262543005276 UPF0302 domain; Region: UPF0302; pfam08864 262543005277 IDEAL domain; Region: IDEAL; pfam08858 262543005278 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 262543005279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543005280 TPR motif; other site 262543005281 binding surface 262543005282 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 262543005283 Tetratricopeptide repeat; Region: TPR_16; pfam13432 262543005284 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 262543005285 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 262543005286 hinge; other site 262543005287 active site 262543005288 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 262543005289 active site 262543005290 dimer interface [polypeptide binding]; other site 262543005291 metal binding site [ion binding]; metal-binding site 262543005292 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 262543005293 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 262543005294 Tetramer interface [polypeptide binding]; other site 262543005295 active site 262543005296 FMN-binding site [chemical binding]; other site 262543005297 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 262543005298 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 262543005299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543005300 S-adenosylmethionine binding site [chemical binding]; other site 262543005301 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 262543005302 active site 262543005303 multimer interface [polypeptide binding]; other site 262543005304 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262543005305 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262543005306 substrate binding pocket [chemical binding]; other site 262543005307 chain length determination region; other site 262543005308 substrate-Mg2+ binding site; other site 262543005309 catalytic residues [active] 262543005310 aspartate-rich region 1; other site 262543005311 active site lid residues [active] 262543005312 aspartate-rich region 2; other site 262543005313 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 262543005314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543005315 S-adenosylmethionine binding site [chemical binding]; other site 262543005316 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 262543005317 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 262543005318 IHF dimer interface [polypeptide binding]; other site 262543005319 IHF - DNA interface [nucleotide binding]; other site 262543005320 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 262543005321 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 262543005322 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 262543005323 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 262543005324 GTP-binding protein Der; Reviewed; Region: PRK00093 262543005325 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 262543005326 G1 box; other site 262543005327 GTP/Mg2+ binding site [chemical binding]; other site 262543005328 Switch I region; other site 262543005329 G2 box; other site 262543005330 Switch II region; other site 262543005331 G3 box; other site 262543005332 G4 box; other site 262543005333 G5 box; other site 262543005334 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 262543005335 G1 box; other site 262543005336 GTP/Mg2+ binding site [chemical binding]; other site 262543005337 Switch I region; other site 262543005338 G2 box; other site 262543005339 G3 box; other site 262543005340 Switch II region; other site 262543005341 G4 box; other site 262543005342 G5 box; other site 262543005343 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 262543005344 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 262543005345 RNA binding site [nucleotide binding]; other site 262543005346 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 262543005347 RNA binding site [nucleotide binding]; other site 262543005348 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 262543005349 RNA binding site [nucleotide binding]; other site 262543005350 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 262543005351 RNA binding site [nucleotide binding]; other site 262543005352 domain interface; other site 262543005353 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262543005354 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262543005355 putative acyl-acceptor binding pocket; other site 262543005356 cytidylate kinase; Provisional; Region: cmk; PRK00023 262543005357 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 262543005358 CMP-binding site; other site 262543005359 The sites determining sugar specificity; other site 262543005360 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 262543005361 Flagellar protein YcgR; Region: YcgR_2; pfam12945 262543005362 PilZ domain; Region: PilZ; pfam07238 262543005363 Protease prsW family; Region: PrsW-protease; pfam13367 262543005364 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 262543005365 active site 262543005366 homodimer interface [polypeptide binding]; other site 262543005367 homotetramer interface [polypeptide binding]; other site 262543005368 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 262543005369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262543005370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543005371 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 262543005372 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 262543005373 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 262543005374 NAD(P) binding site [chemical binding]; other site 262543005375 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 262543005376 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 262543005377 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543005378 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 262543005379 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 262543005380 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262543005381 DNA binding residues [nucleotide binding] 262543005382 B12 binding domain; Region: B12-binding_2; pfam02607 262543005383 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 262543005384 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 262543005385 B12 binding site [chemical binding]; other site 262543005386 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 262543005387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543005388 ATP binding site [chemical binding]; other site 262543005389 putative Mg++ binding site [ion binding]; other site 262543005390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543005391 nucleotide binding region [chemical binding]; other site 262543005392 ATP-binding site [chemical binding]; other site 262543005393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 262543005394 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262543005395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262543005396 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 262543005397 TM-ABC transporter signature motif; other site 262543005398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262543005399 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 262543005400 TM-ABC transporter signature motif; other site 262543005401 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 262543005402 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 262543005403 Walker A/P-loop; other site 262543005404 ATP binding site [chemical binding]; other site 262543005405 Q-loop/lid; other site 262543005406 ABC transporter signature motif; other site 262543005407 Walker B; other site 262543005408 D-loop; other site 262543005409 H-loop/switch region; other site 262543005410 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 262543005411 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 262543005412 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 262543005413 ligand binding site [chemical binding]; other site 262543005414 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262543005415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543005416 DNA-binding site [nucleotide binding]; DNA binding site 262543005417 UTRA domain; Region: UTRA; pfam07702 262543005418 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 262543005419 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 262543005420 ligand binding site [chemical binding]; other site 262543005421 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 262543005422 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262543005423 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 262543005424 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 262543005425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543005426 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 262543005427 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 262543005428 FemAB family; Region: FemAB; pfam02388 262543005429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 262543005430 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 262543005431 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262543005432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262543005433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262543005434 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 262543005435 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 262543005436 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 262543005437 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 262543005438 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 262543005439 RNase E interface [polypeptide binding]; other site 262543005440 trimer interface [polypeptide binding]; other site 262543005441 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 262543005442 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 262543005443 RNase E interface [polypeptide binding]; other site 262543005444 trimer interface [polypeptide binding]; other site 262543005445 active site 262543005446 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 262543005447 putative nucleic acid binding region [nucleotide binding]; other site 262543005448 G-X-X-G motif; other site 262543005449 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 262543005450 RNA binding site [nucleotide binding]; other site 262543005451 domain interface; other site 262543005452 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 262543005453 16S/18S rRNA binding site [nucleotide binding]; other site 262543005454 S13e-L30e interaction site [polypeptide binding]; other site 262543005455 25S rRNA binding site [nucleotide binding]; other site 262543005456 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 262543005457 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 262543005458 active site 262543005459 Riboflavin kinase; Region: Flavokinase; smart00904 262543005460 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 262543005461 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 262543005462 RNA binding site [nucleotide binding]; other site 262543005463 active site 262543005464 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 262543005465 translation initiation factor IF-2; Validated; Region: infB; PRK05306 262543005466 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262543005467 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262543005468 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 262543005469 G1 box; other site 262543005470 putative GEF interaction site [polypeptide binding]; other site 262543005471 GTP/Mg2+ binding site [chemical binding]; other site 262543005472 Switch I region; other site 262543005473 G2 box; other site 262543005474 G3 box; other site 262543005475 Switch II region; other site 262543005476 G4 box; other site 262543005477 G5 box; other site 262543005478 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 262543005479 Translation-initiation factor 2; Region: IF-2; pfam11987 262543005480 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 262543005481 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 262543005482 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 262543005483 putative RNA binding cleft [nucleotide binding]; other site 262543005484 transcription termination factor NusA; Region: NusA; TIGR01953 262543005485 NusA N-terminal domain; Region: NusA_N; pfam08529 262543005486 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 262543005487 RNA binding site [nucleotide binding]; other site 262543005488 homodimer interface [polypeptide binding]; other site 262543005489 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 262543005490 G-X-X-G motif; other site 262543005491 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 262543005492 G-X-X-G motif; other site 262543005493 ribosome maturation protein RimP; Reviewed; Region: PRK00092 262543005494 Sm and related proteins; Region: Sm_like; cl00259 262543005495 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 262543005496 putative oligomer interface [polypeptide binding]; other site 262543005497 putative RNA binding site [nucleotide binding]; other site 262543005498 DNA polymerase III PolC; Validated; Region: polC; PRK00448 262543005499 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 262543005500 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 262543005501 generic binding surface II; other site 262543005502 generic binding surface I; other site 262543005503 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 262543005504 active site 262543005505 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262543005506 active site 262543005507 catalytic site [active] 262543005508 substrate binding site [chemical binding]; other site 262543005509 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 262543005510 prolyl-tRNA synthetase; Provisional; Region: PRK09194 262543005511 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 262543005512 dimer interface [polypeptide binding]; other site 262543005513 motif 1; other site 262543005514 active site 262543005515 motif 2; other site 262543005516 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 262543005517 putative deacylase active site [active] 262543005518 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262543005519 active site 262543005520 motif 3; other site 262543005521 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 262543005522 anticodon binding site; other site 262543005523 RIP metalloprotease RseP; Region: TIGR00054 262543005524 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 262543005525 active site 262543005526 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 262543005527 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 262543005528 protein binding site [polypeptide binding]; other site 262543005529 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 262543005530 putative substrate binding region [chemical binding]; other site 262543005531 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 262543005532 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 262543005533 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 262543005534 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 262543005535 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 262543005536 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 262543005537 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 262543005538 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 262543005539 catalytic residue [active] 262543005540 putative FPP diphosphate binding site; other site 262543005541 putative FPP binding hydrophobic cleft; other site 262543005542 dimer interface [polypeptide binding]; other site 262543005543 putative IPP diphosphate binding site; other site 262543005544 ribosome recycling factor; Reviewed; Region: frr; PRK00083 262543005545 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 262543005546 hinge region; other site 262543005547 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 262543005548 putative nucleotide binding site [chemical binding]; other site 262543005549 uridine monophosphate binding site [chemical binding]; other site 262543005550 homohexameric interface [polypeptide binding]; other site 262543005551 elongation factor Ts; Provisional; Region: tsf; PRK09377 262543005552 UBA/TS-N domain; Region: UBA; pfam00627 262543005553 Elongation factor TS; Region: EF_TS; pfam00889 262543005554 Elongation factor TS; Region: EF_TS; pfam00889 262543005555 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 262543005556 rRNA interaction site [nucleotide binding]; other site 262543005557 S8 interaction site; other site 262543005558 putative laminin-1 binding site; other site 262543005559 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 262543005560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543005561 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262543005562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543005563 DNA binding residues [nucleotide binding] 262543005564 CheD chemotactic sensory transduction; Region: CheD; cl00810 262543005565 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 262543005566 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 262543005567 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 262543005568 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 262543005569 putative binding surface; other site 262543005570 active site 262543005571 P2 response regulator binding domain; Region: P2; pfam07194 262543005572 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 262543005573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543005574 ATP binding site [chemical binding]; other site 262543005575 Mg2+ binding site [ion binding]; other site 262543005576 G-X-G motif; other site 262543005577 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 262543005578 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262543005579 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 262543005580 P-loop; other site 262543005581 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 262543005582 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 262543005583 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262543005584 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 262543005585 FHIPEP family; Region: FHIPEP; pfam00771 262543005586 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 262543005587 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 262543005588 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 262543005589 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 262543005590 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 262543005591 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 262543005592 Response regulator receiver domain; Region: Response_reg; pfam00072 262543005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543005594 active site 262543005595 phosphorylation site [posttranslational modification] 262543005596 intermolecular recognition site; other site 262543005597 dimerization interface [polypeptide binding]; other site 262543005598 flagellar motor switch protein; Validated; Region: PRK08119 262543005599 CheC-like family; Region: CheC; pfam04509 262543005600 CheC-like family; Region: CheC; pfam04509 262543005601 flagellar motor switch protein FliN; Region: fliN; TIGR02480 262543005602 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 262543005603 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 262543005604 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 262543005605 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 262543005606 Flagellar protein (FlbD); Region: FlbD; pfam06289 262543005607 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 262543005608 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 262543005609 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 262543005610 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 262543005611 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 262543005612 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 262543005613 MgtE intracellular N domain; Region: MgtE_N; pfam03448 262543005614 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 262543005615 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 262543005616 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 262543005617 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 262543005618 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 262543005619 Walker A motif/ATP binding site; other site 262543005620 Walker B motif; other site 262543005621 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 262543005622 Flagellar assembly protein FliH; Region: FliH; pfam02108 262543005623 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 262543005624 FliG C-terminal domain; Region: FliG_C; pfam01706 262543005625 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 262543005626 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 262543005627 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 262543005628 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 262543005629 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 262543005630 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 262543005631 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 262543005632 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 262543005633 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 262543005634 transcriptional repressor CodY; Validated; Region: PRK04158 262543005635 CodY GAF-like domain; Region: CodY; pfam06018 262543005636 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 262543005637 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 262543005638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543005639 Walker A motif; other site 262543005640 ATP binding site [chemical binding]; other site 262543005641 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 262543005642 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 262543005643 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 262543005644 active site 262543005645 HslU subunit interaction site [polypeptide binding]; other site 262543005646 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 262543005647 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262543005648 active site 262543005649 DNA binding site [nucleotide binding] 262543005650 Int/Topo IB signature motif; other site 262543005651 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 262543005652 Glucose inhibited division protein A; Region: GIDA; pfam01134 262543005653 DNA topoisomerase I; Validated; Region: PRK05582 262543005654 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 262543005655 active site 262543005656 interdomain interaction site; other site 262543005657 putative metal-binding site [ion binding]; other site 262543005658 nucleotide binding site [chemical binding]; other site 262543005659 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 262543005660 domain I; other site 262543005661 DNA binding groove [nucleotide binding] 262543005662 phosphate binding site [ion binding]; other site 262543005663 domain II; other site 262543005664 domain III; other site 262543005665 nucleotide binding site [chemical binding]; other site 262543005666 catalytic site [active] 262543005667 domain IV; other site 262543005668 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 262543005669 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 262543005670 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 262543005671 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 262543005672 DNA protecting protein DprA; Region: dprA; TIGR00732 262543005673 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 262543005674 CoA binding domain; Region: CoA_binding; pfam02629 262543005675 CoA-ligase; Region: Ligase_CoA; pfam00549 262543005676 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 262543005677 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 262543005678 CoA-ligase; Region: Ligase_CoA; pfam00549 262543005679 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 262543005680 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 262543005681 RNA/DNA hybrid binding site [nucleotide binding]; other site 262543005682 active site 262543005683 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 262543005684 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 262543005685 GTP/Mg2+ binding site [chemical binding]; other site 262543005686 G4 box; other site 262543005687 G5 box; other site 262543005688 G1 box; other site 262543005689 Switch I region; other site 262543005690 G2 box; other site 262543005691 G3 box; other site 262543005692 Switch II region; other site 262543005693 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 262543005694 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262543005695 Catalytic site [active] 262543005696 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262543005697 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 262543005698 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 262543005699 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 262543005700 RimM N-terminal domain; Region: RimM; pfam01782 262543005701 PRC-barrel domain; Region: PRC; pfam05239 262543005702 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 262543005703 signal recognition particle protein; Provisional; Region: PRK10867 262543005704 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 262543005705 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 262543005706 P loop; other site 262543005707 GTP binding site [chemical binding]; other site 262543005708 Signal peptide binding domain; Region: SRP_SPB; pfam02978 262543005709 putative DNA-binding protein; Validated; Region: PRK00118 262543005710 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 262543005711 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 262543005712 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 262543005713 P loop; other site 262543005714 GTP binding site [chemical binding]; other site 262543005715 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 262543005716 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 262543005717 Walker A/P-loop; other site 262543005718 ATP binding site [chemical binding]; other site 262543005719 Q-loop/lid; other site 262543005720 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 262543005721 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 262543005722 ABC transporter signature motif; other site 262543005723 Walker B; other site 262543005724 D-loop; other site 262543005725 H-loop/switch region; other site 262543005726 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 262543005727 ribonuclease III; Reviewed; Region: rnc; PRK00102 262543005728 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 262543005729 dimerization interface [polypeptide binding]; other site 262543005730 active site 262543005731 metal binding site [ion binding]; metal-binding site 262543005732 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 262543005733 dsRNA binding site [nucleotide binding]; other site 262543005734 acyl carrier protein; Provisional; Region: acpP; PRK00982 262543005735 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262543005736 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 262543005737 NAD(P) binding site [chemical binding]; other site 262543005738 homotetramer interface [polypeptide binding]; other site 262543005739 homodimer interface [polypeptide binding]; other site 262543005740 active site 262543005741 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 262543005742 putative phosphate acyltransferase; Provisional; Region: PRK05331 262543005743 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 262543005744 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 262543005745 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 262543005746 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 262543005747 ssDNA binding site; other site 262543005748 generic binding surface II; other site 262543005749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543005750 ATP binding site [chemical binding]; other site 262543005751 putative Mg++ binding site [ion binding]; other site 262543005752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543005753 nucleotide binding region [chemical binding]; other site 262543005754 ATP-binding site [chemical binding]; other site 262543005755 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 262543005756 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 262543005757 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 262543005758 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 262543005759 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 262543005760 putative L-serine binding site [chemical binding]; other site 262543005761 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 262543005762 DAK2 domain; Region: Dak2; pfam02734 262543005763 Asp23 family; Region: Asp23; pfam03780 262543005764 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 262543005765 S-methylmethionine transporter; Provisional; Region: PRK11387 262543005766 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 262543005767 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 262543005768 Thiamine pyrophosphokinase; Region: TPK; cd07995 262543005769 active site 262543005770 dimerization interface [polypeptide binding]; other site 262543005771 thiamine binding site [chemical binding]; other site 262543005772 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 262543005773 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 262543005774 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 262543005775 substrate binding site [chemical binding]; other site 262543005776 hexamer interface [polypeptide binding]; other site 262543005777 metal binding site [ion binding]; metal-binding site 262543005778 GTPase RsgA; Reviewed; Region: PRK00098 262543005779 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 262543005780 RNA binding site [nucleotide binding]; other site 262543005781 homodimer interface [polypeptide binding]; other site 262543005782 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 262543005783 GTPase/Zn-binding domain interface [polypeptide binding]; other site 262543005784 GTP/Mg2+ binding site [chemical binding]; other site 262543005785 G4 box; other site 262543005786 G5 box; other site 262543005787 G1 box; other site 262543005788 Switch I region; other site 262543005789 G2 box; other site 262543005790 G3 box; other site 262543005791 Switch II region; other site 262543005792 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262543005793 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262543005794 active site 262543005795 ATP binding site [chemical binding]; other site 262543005796 substrate binding site [chemical binding]; other site 262543005797 activation loop (A-loop); other site 262543005798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 262543005799 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262543005800 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262543005801 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262543005802 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 262543005803 Protein phosphatase 2C; Region: PP2C; pfam00481 262543005804 active site 262543005805 16S rRNA methyltransferase B; Provisional; Region: PRK14902 262543005806 NusB family; Region: NusB; pfam01029 262543005807 putative RNA binding site [nucleotide binding]; other site 262543005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543005809 S-adenosylmethionine binding site [chemical binding]; other site 262543005810 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 262543005811 active site 262543005812 catalytic residues [active] 262543005813 metal binding site [ion binding]; metal-binding site 262543005814 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 262543005815 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 262543005816 putative active site [active] 262543005817 substrate binding site [chemical binding]; other site 262543005818 putative cosubstrate binding site; other site 262543005819 catalytic site [active] 262543005820 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 262543005821 substrate binding site [chemical binding]; other site 262543005822 primosome assembly protein PriA; Validated; Region: PRK05580 262543005823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543005824 ATP binding site [chemical binding]; other site 262543005825 putative Mg++ binding site [ion binding]; other site 262543005826 helicase superfamily c-terminal domain; Region: HELICc; smart00490 262543005827 nucleotide binding region [chemical binding]; other site 262543005828 ATP-binding site [chemical binding]; other site 262543005829 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 262543005830 Flavoprotein; Region: Flavoprotein; pfam02441 262543005831 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 262543005832 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 262543005833 Guanylate kinase; Region: Guanylate_kin; pfam00625 262543005834 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 262543005835 catalytic site [active] 262543005836 G-X2-G-X-G-K; other site 262543005837 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 262543005838 Domain of unknown function (DUF814); Region: DUF814; pfam05670 262543005839 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 262543005840 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 262543005841 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262543005842 metal-dependent hydrolase; Provisional; Region: PRK00685 262543005843 Predicted transcriptional regulators [Transcription]; Region: COG1733 262543005844 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 262543005845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543005846 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262543005847 active site 262543005848 metal binding site [ion binding]; metal-binding site 262543005849 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 262543005850 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543005851 putative NAD(P) binding site [chemical binding]; other site 262543005852 substrate binding site [chemical binding]; other site 262543005853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 262543005854 Coenzyme A binding pocket [chemical binding]; other site 262543005855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543005856 active site 262543005857 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 262543005858 active site 262543005859 dimer interface [polypeptide binding]; other site 262543005860 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 262543005861 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 262543005862 heterodimer interface [polypeptide binding]; other site 262543005863 active site 262543005864 FMN binding site [chemical binding]; other site 262543005865 homodimer interface [polypeptide binding]; other site 262543005866 substrate binding site [chemical binding]; other site 262543005867 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 262543005868 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 262543005869 FAD binding pocket [chemical binding]; other site 262543005870 FAD binding motif [chemical binding]; other site 262543005871 phosphate binding motif [ion binding]; other site 262543005872 beta-alpha-beta structure motif; other site 262543005873 NAD binding pocket [chemical binding]; other site 262543005874 Iron coordination center [ion binding]; other site 262543005875 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 262543005876 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262543005877 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 262543005878 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 262543005879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262543005880 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543005881 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 262543005882 IMP binding site; other site 262543005883 dimer interface [polypeptide binding]; other site 262543005884 interdomain contacts; other site 262543005885 partial ornithine binding site; other site 262543005886 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 262543005887 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 262543005888 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 262543005889 catalytic site [active] 262543005890 subunit interface [polypeptide binding]; other site 262543005891 dihydroorotase; Validated; Region: pyrC; PRK09357 262543005892 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262543005893 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 262543005894 active site 262543005895 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 262543005896 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 262543005897 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 262543005898 uracil transporter; Provisional; Region: PRK10720 262543005899 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 262543005900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543005901 active site 262543005902 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 262543005903 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543005904 RNA binding surface [nucleotide binding]; other site 262543005905 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 262543005906 active site 262543005907 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 262543005908 lipoprotein signal peptidase; Provisional; Region: PRK14787 262543005909 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 262543005910 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262543005911 active site 262543005912 HIGH motif; other site 262543005913 nucleotide binding site [chemical binding]; other site 262543005914 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 262543005915 active site 262543005916 KMSKS motif; other site 262543005917 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 262543005918 tRNA binding surface [nucleotide binding]; other site 262543005919 anticodon binding site; other site 262543005920 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262543005921 DivIVA protein; Region: DivIVA; pfam05103 262543005922 DivIVA domain; Region: DivI1A_domain; TIGR03544 262543005923 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 262543005924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543005925 RNA binding surface [nucleotide binding]; other site 262543005926 YGGT family; Region: YGGT; pfam02325 262543005927 Protein of unknown function (DUF552); Region: DUF552; pfam04472 262543005928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 262543005929 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262543005930 catalytic residue [active] 262543005931 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 262543005932 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 262543005933 cell division protein FtsZ; Validated; Region: PRK09330 262543005934 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 262543005935 nucleotide binding site [chemical binding]; other site 262543005936 SulA interaction site; other site 262543005937 cell division protein FtsA; Region: ftsA; TIGR01174 262543005938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 262543005939 nucleotide binding site [chemical binding]; other site 262543005940 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 262543005941 Cell division protein FtsA; Region: FtsA; pfam14450 262543005942 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 262543005943 Cell division protein FtsQ; Region: FtsQ; pfam03799 262543005944 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 262543005945 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 262543005946 active site 262543005947 homodimer interface [polypeptide binding]; other site 262543005948 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 262543005949 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262543005950 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262543005951 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 262543005952 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 262543005953 Mg++ binding site [ion binding]; other site 262543005954 putative catalytic motif [active] 262543005955 putative substrate binding site [chemical binding]; other site 262543005956 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 262543005957 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262543005958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262543005959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262543005960 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262543005961 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 262543005962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262543005963 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 262543005964 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 262543005965 Cell division protein FtsL; Region: FtsL; cl11433 262543005966 MraW methylase family; Region: Methyltransf_5; pfam01795 262543005967 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 262543005968 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 262543005969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 262543005970 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 262543005971 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 262543005972 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 262543005973 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 262543005974 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 262543005975 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 262543005976 hypothetical protein; Provisional; Region: PRK13670 262543005977 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 262543005978 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 262543005979 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 262543005980 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262543005981 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 262543005982 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 262543005983 active site 262543005984 (T/H)XGH motif; other site 262543005985 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 262543005986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543005987 S-adenosylmethionine binding site [chemical binding]; other site 262543005988 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 262543005989 Protein of unknown function (DUF964); Region: DUF964; pfam06133 262543005990 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543005991 YugN-like family; Region: YugN; pfam08868 262543005992 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 262543005993 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 262543005994 Cu(I) binding site [ion binding]; other site 262543005995 Protein of unknown function (DUF420); Region: DUF420; pfam04238 262543005996 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 262543005997 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 262543005998 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 262543005999 Subunit I/III interface [polypeptide binding]; other site 262543006000 Subunit III/IV interface [polypeptide binding]; other site 262543006001 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 262543006002 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 262543006003 D-pathway; other site 262543006004 Putative ubiquinol binding site [chemical binding]; other site 262543006005 Low-spin heme (heme b) binding site [chemical binding]; other site 262543006006 Putative water exit pathway; other site 262543006007 Binuclear center (heme o3/CuB) [ion binding]; other site 262543006008 K-pathway; other site 262543006009 Putative proton exit pathway; other site 262543006010 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 262543006011 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 262543006012 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 262543006013 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 262543006014 UbiA prenyltransferase family; Region: UbiA; pfam01040 262543006015 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 262543006016 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 262543006017 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 262543006018 DNA photolyase; Region: DNA_photolyase; pfam00875 262543006019 pyruvate carboxylase; Reviewed; Region: PRK12999 262543006020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262543006021 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 262543006022 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 262543006023 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 262543006024 active site 262543006025 catalytic residues [active] 262543006026 metal binding site [ion binding]; metal-binding site 262543006027 homodimer binding site [polypeptide binding]; other site 262543006028 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262543006029 carboxyltransferase (CT) interaction site; other site 262543006030 biotinylation site [posttranslational modification]; other site 262543006031 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 262543006032 hypothetical protein; Provisional; Region: PRK13666 262543006033 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 262543006034 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 262543006035 putative active site [active] 262543006036 PhoH-like protein; Region: PhoH; pfam02562 262543006037 hypothetical protein; Provisional; Region: PRK06733 262543006038 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 262543006039 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 262543006040 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 262543006041 YlaH-like protein; Region: YlaH; pfam14036 262543006042 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 262543006043 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 262543006044 G1 box; other site 262543006045 putative GEF interaction site [polypeptide binding]; other site 262543006046 GTP/Mg2+ binding site [chemical binding]; other site 262543006047 Switch I region; other site 262543006048 G2 box; other site 262543006049 G3 box; other site 262543006050 Switch II region; other site 262543006051 G4 box; other site 262543006052 G5 box; other site 262543006053 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 262543006054 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 262543006055 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 262543006056 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 262543006057 active site 262543006058 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 262543006059 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 262543006060 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 262543006061 homodimer interface [polypeptide binding]; other site 262543006062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543006063 catalytic residue [active] 262543006064 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 262543006065 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 262543006066 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 262543006067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543006068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543006069 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543006070 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 262543006071 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262543006072 E3 interaction surface; other site 262543006073 lipoyl attachment site [posttranslational modification]; other site 262543006074 e3 binding domain; Region: E3_binding; pfam02817 262543006075 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262543006076 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262543006077 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262543006078 alpha subunit interface [polypeptide binding]; other site 262543006079 TPP binding site [chemical binding]; other site 262543006080 heterodimer interface [polypeptide binding]; other site 262543006081 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262543006082 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 262543006083 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262543006084 TPP-binding site [chemical binding]; other site 262543006085 tetramer interface [polypeptide binding]; other site 262543006086 heterodimer interface [polypeptide binding]; other site 262543006087 phosphorylation loop region [posttranslational modification] 262543006088 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 262543006089 active site 262543006090 catalytic residues [active] 262543006091 metal binding site [ion binding]; metal-binding site 262543006092 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 262543006093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 262543006094 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 262543006095 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 262543006096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543006097 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262543006098 active site 262543006099 motif I; other site 262543006100 motif II; other site 262543006101 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262543006102 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262543006103 TrkA-N domain; Region: TrkA_N; pfam02254 262543006104 TrkA-C domain; Region: TrkA_C; pfam02080 262543006105 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 262543006106 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 262543006107 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 262543006108 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 262543006109 metal binding site [ion binding]; metal-binding site 262543006110 putative dimer interface [polypeptide binding]; other site 262543006111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543006112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543006113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262543006114 dimerization interface [polypeptide binding]; other site 262543006115 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 262543006116 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 262543006117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262543006118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543006119 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 262543006120 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 262543006121 homodimer interface [polypeptide binding]; other site 262543006122 NAD binding pocket [chemical binding]; other site 262543006123 ATP binding pocket [chemical binding]; other site 262543006124 Mg binding site [ion binding]; other site 262543006125 active-site loop [active] 262543006126 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 262543006127 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 262543006128 Virulence factor; Region: Virulence_fact; pfam13769 262543006129 HEAT repeats; Region: HEAT_2; pfam13646 262543006130 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 262543006131 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262543006132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543006133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262543006134 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 262543006135 EDD domain protein, DegV family; Region: DegV; TIGR00762 262543006136 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 262543006137 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 262543006138 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 262543006139 active site 262543006140 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 262543006141 tetramer interfaces [polypeptide binding]; other site 262543006142 binuclear metal-binding site [ion binding]; other site 262543006143 hypothetical protein; Provisional; Region: PRK13679 262543006144 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 262543006145 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 262543006146 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 262543006147 NAD binding site [chemical binding]; other site 262543006148 homotetramer interface [polypeptide binding]; other site 262543006149 homodimer interface [polypeptide binding]; other site 262543006150 substrate binding site [chemical binding]; other site 262543006151 active site 262543006152 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 262543006153 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 262543006154 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 262543006155 active site 262543006156 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 262543006157 ATP-NAD kinase; Region: NAD_kinase; pfam01513 262543006158 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 262543006159 synthetase active site [active] 262543006160 NTP binding site [chemical binding]; other site 262543006161 metal binding site [ion binding]; metal-binding site 262543006162 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 262543006163 putative active site [active] 262543006164 putative metal binding residues [ion binding]; other site 262543006165 signature motif; other site 262543006166 putative triphosphate binding site [ion binding]; other site 262543006167 Thioredoxin; Region: Thioredoxin_5; pfam13743 262543006168 oligoendopeptidase F; Region: pepF; TIGR00181 262543006169 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 262543006170 active site 262543006171 Zn binding site [ion binding]; other site 262543006172 Competence protein CoiA-like family; Region: CoiA; cl11541 262543006173 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 262543006174 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262543006175 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 262543006176 putative active site [active] 262543006177 catalytic site [active] 262543006178 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 262543006179 putative active site [active] 262543006180 catalytic site [active] 262543006181 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 262543006182 classical (c) SDRs; Region: SDR_c; cd05233 262543006183 NAD(P) binding site [chemical binding]; other site 262543006184 active site 262543006185 adaptor protein; Provisional; Region: PRK02315 262543006186 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 262543006187 ArsC family; Region: ArsC; pfam03960 262543006188 putative catalytic residues [active] 262543006189 thiol/disulfide switch; other site 262543006190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 262543006191 Zn2+ binding site [ion binding]; other site 262543006192 Mg2+ binding site [ion binding]; other site 262543006193 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 262543006194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262543006195 Walker A/P-loop; other site 262543006196 ATP binding site [chemical binding]; other site 262543006197 Q-loop/lid; other site 262543006198 ABC transporter signature motif; other site 262543006199 Walker B; other site 262543006200 D-loop; other site 262543006201 H-loop/switch region; other site 262543006202 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262543006203 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 262543006204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262543006205 Walker A/P-loop; other site 262543006206 ATP binding site [chemical binding]; other site 262543006207 Q-loop/lid; other site 262543006208 ABC transporter signature motif; other site 262543006209 Walker B; other site 262543006210 D-loop; other site 262543006211 H-loop/switch region; other site 262543006212 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 262543006213 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 262543006214 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 262543006215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543006216 dimer interface [polypeptide binding]; other site 262543006217 conserved gate region; other site 262543006218 putative PBP binding loops; other site 262543006219 ABC-ATPase subunit interface; other site 262543006220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262543006221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543006222 dimer interface [polypeptide binding]; other site 262543006223 conserved gate region; other site 262543006224 putative PBP binding loops; other site 262543006225 ABC-ATPase subunit interface; other site 262543006226 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262543006227 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 262543006228 peptide binding site [polypeptide binding]; other site 262543006229 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 262543006230 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 262543006231 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 262543006232 active site 262543006233 HIGH motif; other site 262543006234 dimer interface [polypeptide binding]; other site 262543006235 KMSKS motif; other site 262543006236 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543006237 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543006238 Integrase core domain; Region: rve; pfam00665 262543006239 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262543006240 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 262543006241 peptide binding site [polypeptide binding]; other site 262543006242 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543006243 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543006244 Integrase core domain; Region: rve; pfam00665 262543006245 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 262543006246 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262543006247 dimer interface [polypeptide binding]; other site 262543006248 active site 262543006249 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 262543006250 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 262543006251 dimer interface [polypeptide binding]; other site 262543006252 active site 262543006253 CoA binding pocket [chemical binding]; other site 262543006254 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 262543006255 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 262543006256 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 262543006257 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 262543006258 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 262543006259 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 262543006260 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 262543006261 ATP-binding site [chemical binding]; other site 262543006262 Sugar specificity; other site 262543006263 Pyrimidine base specificity; other site 262543006264 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262543006265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543006266 S-adenosylmethionine binding site [chemical binding]; other site 262543006267 YceG-like family; Region: YceG; pfam02618 262543006268 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 262543006269 dimerization interface [polypeptide binding]; other site 262543006270 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 262543006271 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 262543006272 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 262543006273 hypothetical protein; Provisional; Region: PRK05473 262543006274 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 262543006275 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 262543006276 motif 1; other site 262543006277 active site 262543006278 motif 2; other site 262543006279 motif 3; other site 262543006280 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 262543006281 DHHA1 domain; Region: DHHA1; pfam02272 262543006282 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 262543006283 AAA domain; Region: AAA_30; pfam13604 262543006284 Family description; Region: UvrD_C_2; pfam13538 262543006285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262543006286 active site 262543006287 metal binding site [ion binding]; metal-binding site 262543006288 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543006289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543006290 binding surface 262543006291 TPR repeat; Region: TPR_11; pfam13414 262543006292 TPR motif; other site 262543006293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 262543006294 binding surface 262543006295 TPR motif; other site 262543006296 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 262543006297 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 262543006298 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 262543006299 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 262543006300 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543006301 catalytic residue [active] 262543006302 Rrf2 family protein; Region: rrf2_super; TIGR00738 262543006303 Transcriptional regulator; Region: Rrf2; pfam02082 262543006304 recombination factor protein RarA; Reviewed; Region: PRK13342 262543006305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543006306 Walker A motif; other site 262543006307 ATP binding site [chemical binding]; other site 262543006308 Walker B motif; other site 262543006309 arginine finger; other site 262543006310 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 262543006311 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 262543006312 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 262543006313 putative ATP binding site [chemical binding]; other site 262543006314 putative substrate interface [chemical binding]; other site 262543006315 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 262543006316 DNA photolyase; Region: DNA_photolyase; pfam00875 262543006317 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 262543006318 active site 262543006319 DNA binding site [nucleotide binding] 262543006320 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 262543006321 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 262543006322 dimer interface [polypeptide binding]; other site 262543006323 anticodon binding site; other site 262543006324 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 262543006325 homodimer interface [polypeptide binding]; other site 262543006326 motif 1; other site 262543006327 active site 262543006328 motif 2; other site 262543006329 GAD domain; Region: GAD; pfam02938 262543006330 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262543006331 active site 262543006332 motif 3; other site 262543006333 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 262543006334 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 262543006335 dimer interface [polypeptide binding]; other site 262543006336 motif 1; other site 262543006337 active site 262543006338 motif 2; other site 262543006339 motif 3; other site 262543006340 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 262543006341 anticodon binding site; other site 262543006342 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 262543006343 putative active site [active] 262543006344 dimerization interface [polypeptide binding]; other site 262543006345 putative tRNAtyr binding site [nucleotide binding]; other site 262543006346 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 262543006347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543006348 Zn2+ binding site [ion binding]; other site 262543006349 Mg2+ binding site [ion binding]; other site 262543006350 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 262543006351 synthetase active site [active] 262543006352 NTP binding site [chemical binding]; other site 262543006353 metal binding site [ion binding]; metal-binding site 262543006354 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 262543006355 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 262543006356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543006357 active site 262543006358 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 262543006359 DHH family; Region: DHH; pfam01368 262543006360 DHHA1 domain; Region: DHHA1; pfam02272 262543006361 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 262543006362 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 262543006363 Protein export membrane protein; Region: SecD_SecF; pfam02355 262543006364 protein-export membrane protein SecD; Region: secD; TIGR01129 262543006365 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 262543006366 Preprotein translocase subunit; Region: YajC; pfam02699 262543006367 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 262543006368 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 262543006369 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 262543006370 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 262543006371 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 262543006372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543006373 Walker A motif; other site 262543006374 ATP binding site [chemical binding]; other site 262543006375 Walker B motif; other site 262543006376 arginine finger; other site 262543006377 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 262543006378 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 262543006379 RuvA N terminal domain; Region: RuvA_N; pfam01330 262543006380 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 262543006381 quinolinate synthetase; Provisional; Region: PRK09375 262543006382 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 262543006383 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 262543006384 dimerization interface [polypeptide binding]; other site 262543006385 active site 262543006386 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 262543006387 L-aspartate oxidase; Provisional; Region: PRK06175 262543006388 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262543006389 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 262543006390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543006391 catalytic residue [active] 262543006392 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 262543006393 HTH domain; Region: HTH_11; pfam08279 262543006394 3H domain; Region: 3H; pfam02829 262543006395 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262543006396 Domain of unknown function DUF21; Region: DUF21; pfam01595 262543006397 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262543006398 Transporter associated domain; Region: CorC_HlyC; smart01091 262543006399 GTPase CgtA; Reviewed; Region: obgE; PRK12297 262543006400 GTP1/OBG; Region: GTP1_OBG; pfam01018 262543006401 Obg GTPase; Region: Obg; cd01898 262543006402 G1 box; other site 262543006403 GTP/Mg2+ binding site [chemical binding]; other site 262543006404 Switch I region; other site 262543006405 G2 box; other site 262543006406 G3 box; other site 262543006407 Switch II region; other site 262543006408 G4 box; other site 262543006409 G5 box; other site 262543006410 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 262543006411 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 262543006412 Protein of unknown function (DUF464); Region: DUF464; pfam04327 262543006413 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 262543006414 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 262543006415 Ribosomal protein L21 leader as predicted by Rfam(RF 00559), score 39.95 262543006416 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 262543006417 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 262543006418 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 262543006419 Switch I; other site 262543006420 Switch II; other site 262543006421 septum formation inhibitor; Reviewed; Region: minC; PRK00513 262543006422 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 262543006423 rod shape-determining protein MreC; Provisional; Region: PRK13922 262543006424 rod shape-determining protein MreC; Region: MreC; pfam04085 262543006425 rod shape-determining protein MreB; Provisional; Region: PRK13927 262543006426 MreB and similar proteins; Region: MreB_like; cd10225 262543006427 nucleotide binding site [chemical binding]; other site 262543006428 Mg binding site [ion binding]; other site 262543006429 putative protofilament interaction site [polypeptide binding]; other site 262543006430 RodZ interaction site [polypeptide binding]; other site 262543006431 hypothetical protein; Reviewed; Region: PRK00024 262543006432 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 262543006433 MPN+ (JAMM) motif; other site 262543006434 Zinc-binding site [ion binding]; other site 262543006435 Maf-like protein; Region: Maf; pfam02545 262543006436 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 262543006437 active site 262543006438 dimer interface [polypeptide binding]; other site 262543006439 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 262543006440 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 262543006441 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 262543006442 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 262543006443 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 262543006444 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 262543006445 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 262543006446 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 262543006447 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262543006448 Walker A motif; other site 262543006449 ATP binding site [chemical binding]; other site 262543006450 Walker B motif; other site 262543006451 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 262543006452 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 262543006453 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 262543006454 Walker A motif; other site 262543006455 ATP binding site [chemical binding]; other site 262543006456 Walker B motif; other site 262543006457 VanW like protein; Region: VanW; pfam04294 262543006458 G5 domain; Region: G5; pfam07501 262543006459 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 262543006460 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 262543006461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262543006462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262543006463 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 262543006464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262543006465 active site 262543006466 HIGH motif; other site 262543006467 nucleotide binding site [chemical binding]; other site 262543006468 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 262543006469 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 262543006470 active site 262543006471 KMSKS motif; other site 262543006472 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 262543006473 tRNA binding surface [nucleotide binding]; other site 262543006474 anticodon binding site; other site 262543006475 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 262543006476 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 262543006477 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262543006478 inhibitor-cofactor binding pocket; inhibition site 262543006479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543006480 catalytic residue [active] 262543006481 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 262543006482 dimer interface [polypeptide binding]; other site 262543006483 active site 262543006484 Schiff base residues; other site 262543006485 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 262543006486 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 262543006487 active site 262543006488 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 262543006489 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 262543006490 domain interfaces; other site 262543006491 active site 262543006492 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 262543006493 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 262543006494 tRNA; other site 262543006495 putative tRNA binding site [nucleotide binding]; other site 262543006496 putative NADP binding site [chemical binding]; other site 262543006497 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 262543006498 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 262543006499 Domain of unknown function DUF20; Region: UPF0118; pfam01594 262543006500 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 262543006501 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 262543006502 DXD motif; other site 262543006503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543006504 Response regulator receiver domain; Region: Response_reg; pfam00072 262543006505 active site 262543006506 phosphorylation site [posttranslational modification] 262543006507 intermolecular recognition site; other site 262543006508 dimerization interface [polypeptide binding]; other site 262543006509 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 262543006510 G1 box; other site 262543006511 GTP/Mg2+ binding site [chemical binding]; other site 262543006512 Switch I region; other site 262543006513 G2 box; other site 262543006514 G3 box; other site 262543006515 Switch II region; other site 262543006516 G4 box; other site 262543006517 G5 box; other site 262543006518 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 262543006519 Found in ATP-dependent protease La (LON); Region: LON; smart00464 262543006520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543006521 Walker A motif; other site 262543006522 ATP binding site [chemical binding]; other site 262543006523 Walker B motif; other site 262543006524 arginine finger; other site 262543006525 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262543006526 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 262543006527 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 262543006528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543006529 Walker A motif; other site 262543006530 ATP binding site [chemical binding]; other site 262543006531 Walker B motif; other site 262543006532 arginine finger; other site 262543006533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 262543006534 trigger factor; Provisional; Region: tig; PRK01490 262543006535 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 262543006536 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 262543006537 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 262543006538 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 262543006539 active site 262543006540 metal binding site [ion binding]; metal-binding site 262543006541 homotetramer interface [polypeptide binding]; other site 262543006542 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 262543006543 active site 262543006544 dimerization interface [polypeptide binding]; other site 262543006545 ribonuclease PH; Reviewed; Region: rph; PRK00173 262543006546 Ribonuclease PH; Region: RNase_PH_bact; cd11362 262543006547 hexamer interface [polypeptide binding]; other site 262543006548 active site 262543006549 glutamate racemase; Provisional; Region: PRK00865 262543006550 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 262543006551 dimerization domain swap beta strand [polypeptide binding]; other site 262543006552 regulatory protein interface [polypeptide binding]; other site 262543006553 active site 262543006554 regulatory phosphorylation site [posttranslational modification]; other site 262543006555 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 262543006556 active site 262543006557 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 262543006558 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 262543006559 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 262543006560 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 262543006561 L-aspartate oxidase; Provisional; Region: PRK06175 262543006562 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 262543006563 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 262543006564 putative Iron-sulfur protein interface [polypeptide binding]; other site 262543006565 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 262543006566 proximal heme binding site [chemical binding]; other site 262543006567 distal heme binding site [chemical binding]; other site 262543006568 putative dimer interface [polypeptide binding]; other site 262543006569 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 262543006570 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 262543006571 pentamer interface [polypeptide binding]; other site 262543006572 dodecaamer interface [polypeptide binding]; other site 262543006573 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 262543006574 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 262543006575 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 262543006576 GIY-YIG motif/motif A; other site 262543006577 active site 262543006578 catalytic site [active] 262543006579 putative DNA binding site [nucleotide binding]; other site 262543006580 metal binding site [ion binding]; metal-binding site 262543006581 UvrB/uvrC motif; Region: UVR; pfam02151 262543006582 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 262543006583 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 262543006584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543006585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543006586 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543006587 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262543006588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543006589 active site 262543006590 metal binding site [ion binding]; metal-binding site 262543006591 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262543006592 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262543006593 catalytic residues [active] 262543006594 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 262543006595 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 262543006596 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 262543006597 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 262543006598 Ligand binding site [chemical binding]; other site 262543006599 Electron transfer flavoprotein domain; Region: ETF; pfam01012 262543006600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262543006601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543006602 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 262543006603 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 262543006604 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 262543006605 acyl-activating enzyme (AAE) consensus motif; other site 262543006606 putative AMP binding site [chemical binding]; other site 262543006607 putative active site [active] 262543006608 putative CoA binding site [chemical binding]; other site 262543006609 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543006610 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543006611 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543006612 Predicted membrane protein [Function unknown]; Region: COG3766 262543006613 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 262543006614 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 262543006615 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 262543006616 MutS domain III; Region: MutS_III; pfam05192 262543006617 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 262543006618 Walker A/P-loop; other site 262543006619 ATP binding site [chemical binding]; other site 262543006620 Q-loop/lid; other site 262543006621 ABC transporter signature motif; other site 262543006622 Walker B; other site 262543006623 D-loop; other site 262543006624 H-loop/switch region; other site 262543006625 Smr domain; Region: Smr; pfam01713 262543006626 hypothetical protein; Provisional; Region: PRK08609 262543006627 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 262543006628 active site 262543006629 primer binding site [nucleotide binding]; other site 262543006630 NTP binding site [chemical binding]; other site 262543006631 metal binding triad [ion binding]; metal-binding site 262543006632 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 262543006633 active site 262543006634 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 262543006635 Colicin V production protein; Region: Colicin_V; pfam02674 262543006636 Cell division protein ZapA; Region: ZapA; cl01146 262543006637 ribonuclease HIII; Provisional; Region: PRK00996 262543006638 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 262543006639 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 262543006640 RNA/DNA hybrid binding site [nucleotide binding]; other site 262543006641 active site 262543006642 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 262543006643 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262543006644 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262543006645 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262543006646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543006647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543006648 active site 262543006649 phosphorylation site [posttranslational modification] 262543006650 intermolecular recognition site; other site 262543006651 dimerization interface [polypeptide binding]; other site 262543006652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543006653 DNA binding site [nucleotide binding] 262543006654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543006655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543006656 dimerization interface [polypeptide binding]; other site 262543006657 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 262543006658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543006659 dimer interface [polypeptide binding]; other site 262543006660 phosphorylation site [posttranslational modification] 262543006661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543006662 ATP binding site [chemical binding]; other site 262543006663 Mg2+ binding site [ion binding]; other site 262543006664 G-X-G motif; other site 262543006665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543006666 MarR family; Region: MarR_2; pfam12802 262543006667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543006668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543006669 putative substrate translocation pore; other site 262543006670 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262543006671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262543006672 Walker A/P-loop; other site 262543006673 ATP binding site [chemical binding]; other site 262543006674 Q-loop/lid; other site 262543006675 ABC transporter signature motif; other site 262543006676 Walker B; other site 262543006677 D-loop; other site 262543006678 H-loop/switch region; other site 262543006679 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 262543006680 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 262543006681 FtsX-like permease family; Region: FtsX; pfam02687 262543006682 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 262543006683 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 262543006684 putative tRNA-binding site [nucleotide binding]; other site 262543006685 B3/4 domain; Region: B3_4; pfam03483 262543006686 tRNA synthetase B5 domain; Region: B5; smart00874 262543006687 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 262543006688 dimer interface [polypeptide binding]; other site 262543006689 motif 1; other site 262543006690 motif 3; other site 262543006691 motif 2; other site 262543006692 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 262543006693 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 262543006694 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 262543006695 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 262543006696 dimer interface [polypeptide binding]; other site 262543006697 motif 1; other site 262543006698 active site 262543006699 motif 2; other site 262543006700 motif 3; other site 262543006701 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262543006702 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 262543006703 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262543006704 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262543006705 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 262543006706 oligomer interface [polypeptide binding]; other site 262543006707 active site 262543006708 metal binding site [ion binding]; metal-binding site 262543006709 dUTPase; Region: dUTPase_2; pfam08761 262543006710 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 262543006711 active site 262543006712 homodimer interface [polypeptide binding]; other site 262543006713 metal binding site [ion binding]; metal-binding site 262543006714 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 262543006715 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 262543006716 23S rRNA binding site [nucleotide binding]; other site 262543006717 L21 binding site [polypeptide binding]; other site 262543006718 L13 binding site [polypeptide binding]; other site 262543006719 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 262543006720 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 262543006721 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 262543006722 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 262543006723 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 262543006724 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 262543006725 tetramer interface [polypeptide binding]; other site 262543006726 heme binding pocket [chemical binding]; other site 262543006727 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 262543006728 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 262543006729 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 262543006730 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 262543006731 active site 262543006732 dimer interface [polypeptide binding]; other site 262543006733 motif 1; other site 262543006734 motif 2; other site 262543006735 motif 3; other site 262543006736 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 262543006737 anticodon binding site; other site 262543006738 primosomal protein DnaI; Reviewed; Region: PRK08939 262543006739 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 262543006740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262543006741 Walker A motif; other site 262543006742 ATP binding site [chemical binding]; other site 262543006743 Walker B motif; other site 262543006744 arginine finger; other site 262543006745 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 262543006746 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 262543006747 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 262543006748 ATP cone domain; Region: ATP-cone; pfam03477 262543006749 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 262543006750 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 262543006751 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 262543006752 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 262543006753 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 262543006754 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 262543006755 CoA-binding site [chemical binding]; other site 262543006756 ATP-binding [chemical binding]; other site 262543006757 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 262543006758 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 262543006759 DNA binding site [nucleotide binding] 262543006760 catalytic residue [active] 262543006761 H2TH interface [polypeptide binding]; other site 262543006762 putative catalytic residues [active] 262543006763 turnover-facilitating residue; other site 262543006764 intercalation triad [nucleotide binding]; other site 262543006765 8OG recognition residue [nucleotide binding]; other site 262543006766 putative reading head residues; other site 262543006767 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262543006768 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262543006769 DNA polymerase I; Provisional; Region: PRK05755 262543006770 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 262543006771 active site 262543006772 metal binding site 1 [ion binding]; metal-binding site 262543006773 putative 5' ssDNA interaction site; other site 262543006774 metal binding site 3; metal-binding site 262543006775 metal binding site 2 [ion binding]; metal-binding site 262543006776 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 262543006777 putative DNA binding site [nucleotide binding]; other site 262543006778 putative metal binding site [ion binding]; other site 262543006779 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 262543006780 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 262543006781 active site 262543006782 DNA binding site [nucleotide binding] 262543006783 catalytic site [active] 262543006784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543006785 dimerization interface [polypeptide binding]; other site 262543006786 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 262543006787 PAS domain; Region: PAS; smart00091 262543006788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543006789 dimer interface [polypeptide binding]; other site 262543006790 phosphorylation site [posttranslational modification] 262543006791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543006792 ATP binding site [chemical binding]; other site 262543006793 G-X-G motif; other site 262543006794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543006795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543006796 active site 262543006797 phosphorylation site [posttranslational modification] 262543006798 intermolecular recognition site; other site 262543006799 dimerization interface [polypeptide binding]; other site 262543006800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543006801 DNA binding site [nucleotide binding] 262543006802 Divergent PAP2 family; Region: DUF212; pfam02681 262543006803 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 262543006804 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262543006805 NAD binding site [chemical binding]; other site 262543006806 catalytic Zn binding site [ion binding]; other site 262543006807 structural Zn binding site [ion binding]; other site 262543006808 malate dehydrogenase; Reviewed; Region: PRK06223 262543006809 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 262543006810 NAD(P) binding site [chemical binding]; other site 262543006811 dimer interface [polypeptide binding]; other site 262543006812 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262543006813 substrate binding site [chemical binding]; other site 262543006814 isocitrate dehydrogenase; Reviewed; Region: PRK07006 262543006815 isocitrate dehydrogenase; Validated; Region: PRK07362 262543006816 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 262543006817 dimer interface [polypeptide binding]; other site 262543006818 Citrate synthase; Region: Citrate_synt; pfam00285 262543006819 active site 262543006820 citrylCoA binding site [chemical binding]; other site 262543006821 oxalacetate/citrate binding site [chemical binding]; other site 262543006822 coenzyme A binding site [chemical binding]; other site 262543006823 catalytic triad [active] 262543006824 Protein of unknown function (DUF441); Region: DUF441; pfam04284 262543006825 pyruvate kinase; Provisional; Region: PRK06354 262543006826 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 262543006827 domain interfaces; other site 262543006828 active site 262543006829 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 262543006830 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 262543006831 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 262543006832 active site 262543006833 ADP/pyrophosphate binding site [chemical binding]; other site 262543006834 dimerization interface [polypeptide binding]; other site 262543006835 allosteric effector site; other site 262543006836 fructose-1,6-bisphosphate binding site; other site 262543006837 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 262543006838 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 262543006839 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 262543006840 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262543006841 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262543006842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543006843 DNA-binding site [nucleotide binding]; DNA binding site 262543006844 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 262543006845 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 262543006846 active site 262543006847 PHP Thumb interface [polypeptide binding]; other site 262543006848 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 262543006849 generic binding surface I; other site 262543006850 generic binding surface II; other site 262543006851 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 262543006852 DHH family; Region: DHH; pfam01368 262543006853 DHHA1 domain; Region: DHHA1; pfam02272 262543006854 YtpI-like protein; Region: YtpI; pfam14007 262543006855 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 262543006856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 262543006857 DNA-binding site [nucleotide binding]; DNA binding site 262543006858 DRTGG domain; Region: DRTGG; pfam07085 262543006859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 262543006860 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 262543006861 active site 2 [active] 262543006862 active site 1 [active] 262543006863 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262543006864 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262543006865 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 262543006866 active site 262543006867 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 262543006868 classical (c) SDRs; Region: SDR_c; cd05233 262543006869 NAD(P) binding site [chemical binding]; other site 262543006870 active site 262543006871 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262543006872 Ligand Binding Site [chemical binding]; other site 262543006873 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543006874 3D domain; Region: 3D; cl01439 262543006875 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543006876 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543006877 Integrase core domain; Region: rve; pfam00665 262543006878 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 262543006879 propionate/acetate kinase; Provisional; Region: PRK12379 262543006880 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 262543006881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543006882 S-adenosylmethionine binding site [chemical binding]; other site 262543006883 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 262543006884 dimer interface [polypeptide binding]; other site 262543006885 catalytic triad [active] 262543006886 peroxidatic and resolving cysteines [active] 262543006887 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 262543006888 ATP-NAD kinase; Region: NAD_kinase; pfam01513 262543006889 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 262543006890 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 262543006891 active site 262543006892 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 262543006893 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 262543006894 GAF domain; Region: GAF_2; pfam13185 262543006895 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 262543006896 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 262543006897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543006898 RNA binding surface [nucleotide binding]; other site 262543006899 BioY family; Region: BioY; pfam02632 262543006900 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 262543006901 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 262543006902 active site 262543006903 HIGH motif; other site 262543006904 dimer interface [polypeptide binding]; other site 262543006905 KMSKS motif; other site 262543006906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543006907 RNA binding surface [nucleotide binding]; other site 262543006908 Transglycosylase; Region: Transgly; pfam00912 262543006909 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 262543006910 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 262543006911 acetyl-CoA synthetase; Provisional; Region: PRK04319 262543006912 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 262543006913 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 262543006914 active site 262543006915 acyl-activating enzyme (AAE) consensus motif; other site 262543006916 putative CoA binding site [chemical binding]; other site 262543006917 AMP binding site [chemical binding]; other site 262543006918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543006919 Coenzyme A binding pocket [chemical binding]; other site 262543006920 FOG: CBS domain [General function prediction only]; Region: COG0517 262543006921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 262543006922 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 262543006923 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 262543006924 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 262543006925 active site 262543006926 Zn binding site [ion binding]; other site 262543006927 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 262543006928 YtkA-like; Region: YtkA; pfam13115 262543006929 catabolite control protein A; Region: ccpA; TIGR01481 262543006930 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262543006931 DNA binding site [nucleotide binding] 262543006932 domain linker motif; other site 262543006933 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 262543006934 dimerization interface [polypeptide binding]; other site 262543006935 effector binding site; other site 262543006936 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 262543006937 Chorismate mutase type II; Region: CM_2; cl00693 262543006938 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 262543006939 YtxH-like protein; Region: YtxH; cl02079 262543006940 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 262543006941 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 262543006942 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 262543006943 Ferritin-like domain; Region: Ferritin; pfam00210 262543006944 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 262543006945 dimerization interface [polypeptide binding]; other site 262543006946 DPS ferroxidase diiron center [ion binding]; other site 262543006947 ion pore; other site 262543006948 hypothetical protein; Provisional; Region: PRK04164 262543006949 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543006950 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 262543006951 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262543006952 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262543006953 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262543006954 ribonuclease E; Reviewed; Region: rne; PRK10811 262543006955 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 262543006956 putative tRNA-binding site [nucleotide binding]; other site 262543006957 hypothetical protein; Provisional; Region: PRK13668 262543006958 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262543006959 catalytic residues [active] 262543006960 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 262543006961 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 262543006962 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262543006963 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 262543006964 oligomer interface [polypeptide binding]; other site 262543006965 active site 262543006966 metal binding site [ion binding]; metal-binding site 262543006967 Predicted small secreted protein [Function unknown]; Region: COG5584 262543006968 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 262543006969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543006970 S-adenosylmethionine binding site [chemical binding]; other site 262543006971 acetolactate synthase; Reviewed; Region: PRK08617 262543006972 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262543006973 PYR/PP interface [polypeptide binding]; other site 262543006974 dimer interface [polypeptide binding]; other site 262543006975 TPP binding site [chemical binding]; other site 262543006976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262543006977 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 262543006978 TPP-binding site [chemical binding]; other site 262543006979 dimer interface [polypeptide binding]; other site 262543006980 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 262543006981 Phosphotransferase enzyme family; Region: APH; pfam01636 262543006982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 262543006983 active site 262543006984 substrate binding site [chemical binding]; other site 262543006985 ATP binding site [chemical binding]; other site 262543006986 pullulanase, type I; Region: pulA_typeI; TIGR02104 262543006987 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 262543006988 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 262543006989 Ca binding site [ion binding]; other site 262543006990 active site 262543006991 catalytic site [active] 262543006992 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 262543006993 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 262543006994 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 262543006995 sugar efflux transporter; Region: 2A0120; TIGR00899 262543006996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543006997 putative substrate translocation pore; other site 262543006998 dipeptidase PepV; Reviewed; Region: PRK07318 262543006999 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 262543007000 active site 262543007001 metal binding site [ion binding]; metal-binding site 262543007002 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 262543007003 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 262543007004 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262543007005 NAD(P) binding site [chemical binding]; other site 262543007006 putative active site [active] 262543007007 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 262543007008 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262543007009 RNA binding surface [nucleotide binding]; other site 262543007010 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 262543007011 active site 262543007012 uracil binding [chemical binding]; other site 262543007013 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 262543007014 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 262543007015 HI0933-like protein; Region: HI0933_like; pfam03486 262543007016 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 262543007017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543007018 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 262543007019 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 262543007020 HIGH motif; other site 262543007021 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 262543007022 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 262543007023 active site 262543007024 KMSKS motif; other site 262543007025 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 262543007026 tRNA binding surface [nucleotide binding]; other site 262543007027 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 262543007028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543007029 motif II; other site 262543007030 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 262543007031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543007032 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543007033 putative substrate translocation pore; other site 262543007034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262543007035 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 262543007036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 262543007037 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543007038 Helix-turn-helix domain; Region: HTH_28; pfam13518 262543007039 Winged helix-turn helix; Region: HTH_29; pfam13551 262543007040 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262543007041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543007042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007043 Coenzyme A binding pocket [chemical binding]; other site 262543007044 S-adenosylmethionine synthetase; Validated; Region: PRK05250 262543007045 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 262543007046 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 262543007047 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 262543007048 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 262543007049 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 262543007050 active site 262543007051 substrate-binding site [chemical binding]; other site 262543007052 metal-binding site [ion binding] 262543007053 ATP binding site [chemical binding]; other site 262543007054 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 262543007055 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543007056 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262543007057 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262543007058 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 262543007059 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 262543007060 nudix motif; other site 262543007061 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 262543007062 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 262543007063 active site 262543007064 dimer interface [polypeptide binding]; other site 262543007065 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 262543007066 dimer interface [polypeptide binding]; other site 262543007067 active site 262543007068 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 262543007069 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 262543007070 dimer interface [polypeptide binding]; other site 262543007071 active site 262543007072 metal binding site [ion binding]; metal-binding site 262543007073 general stress protein 13; Validated; Region: PRK08059 262543007074 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 262543007075 RNA binding site [nucleotide binding]; other site 262543007076 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 262543007077 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 262543007078 dimer interface [polypeptide binding]; other site 262543007079 putative radical transfer pathway; other site 262543007080 diiron center [ion binding]; other site 262543007081 tyrosyl radical; other site 262543007082 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262543007083 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 262543007084 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 262543007085 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 262543007086 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 262543007087 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 262543007088 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 262543007089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262543007090 active site 262543007091 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262543007092 AsnC family; Region: AsnC_trans_reg; pfam01037 262543007093 hypothetical protein; Validated; Region: PRK07682 262543007094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262543007095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543007096 homodimer interface [polypeptide binding]; other site 262543007097 catalytic residue [active] 262543007098 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 262543007099 homodimer interface [polypeptide binding]; other site 262543007100 metal binding site [ion binding]; metal-binding site 262543007101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 262543007102 metal binding site [ion binding]; metal-binding site 262543007103 Domain of unknown function DUF20; Region: UPF0118; pfam01594 262543007104 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 262543007105 Protein of unknown function (DUF429); Region: DUF429; pfam04250 262543007106 multifunctional aminopeptidase A; Provisional; Region: PRK00913 262543007107 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 262543007108 interface (dimer of trimers) [polypeptide binding]; other site 262543007109 Substrate-binding/catalytic site; other site 262543007110 Zn-binding sites [ion binding]; other site 262543007111 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 262543007112 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 262543007113 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 262543007114 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 262543007115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543007117 putative substrate translocation pore; other site 262543007118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543007119 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 262543007120 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543007121 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543007122 active site turn [active] 262543007123 phosphorylation site [posttranslational modification] 262543007124 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 262543007125 HPr interaction site; other site 262543007126 glycerol kinase (GK) interaction site [polypeptide binding]; other site 262543007127 active site 262543007128 phosphorylation site [posttranslational modification] 262543007129 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543007130 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 262543007131 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543007132 active site turn [active] 262543007133 phosphorylation site [posttranslational modification] 262543007134 transcriptional antiterminator BglG; Provisional; Region: PRK09772 262543007135 CAT RNA binding domain; Region: CAT_RBD; smart01061 262543007136 PRD domain; Region: PRD; pfam00874 262543007137 PRD domain; Region: PRD; pfam00874 262543007138 Putative membrane protein; Region: YuiB; pfam14068 262543007139 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262543007140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543007141 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 262543007142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543007143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543007144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543007145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007146 Coenzyme A binding pocket [chemical binding]; other site 262543007147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543007149 Coenzyme A binding pocket [chemical binding]; other site 262543007150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543007151 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262543007152 NAD(P) binding site [chemical binding]; other site 262543007153 active site 262543007154 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 262543007155 Predicted membrane protein [Function unknown]; Region: COG3601 262543007156 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 262543007157 hypothetical protein; Provisional; Region: PRK13669 262543007158 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262543007159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543007160 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 262543007161 NifU-like domain; Region: NifU; cl00484 262543007162 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 262543007163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543007164 active site 262543007165 motif I; other site 262543007166 motif II; other site 262543007167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543007168 Uncharacterized conserved protein [Function unknown]; Region: COG2445 262543007169 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 262543007170 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 262543007171 putative active site [active] 262543007172 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 262543007173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 262543007174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 262543007175 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 262543007176 Heat induced stress protein YflT; Region: YflT; pfam11181 262543007177 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 262543007178 lipoyl synthase; Provisional; Region: PRK05481 262543007179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543007180 FeS/SAM binding site; other site 262543007181 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 262543007182 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 262543007183 active site 262543007184 metal binding site [ion binding]; metal-binding site 262543007185 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 262543007186 Protein of unknown function DUF72; Region: DUF72; pfam01904 262543007187 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 262543007188 FeS assembly protein SufB; Region: sufB; TIGR01980 262543007189 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 262543007190 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 262543007191 trimerization site [polypeptide binding]; other site 262543007192 active site 262543007193 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262543007194 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 262543007195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262543007196 catalytic residue [active] 262543007197 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 262543007198 FeS assembly protein SufD; Region: sufD; TIGR01981 262543007199 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 262543007200 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 262543007201 Walker A/P-loop; other site 262543007202 ATP binding site [chemical binding]; other site 262543007203 Q-loop/lid; other site 262543007204 ABC transporter signature motif; other site 262543007205 Walker B; other site 262543007206 D-loop; other site 262543007207 H-loop/switch region; other site 262543007208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543007209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262543007210 putative substrate translocation pore; other site 262543007211 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 262543007212 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 262543007213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543007214 dimer interface [polypeptide binding]; other site 262543007215 conserved gate region; other site 262543007216 ABC-ATPase subunit interface; other site 262543007217 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 262543007218 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 262543007219 Walker A/P-loop; other site 262543007220 ATP binding site [chemical binding]; other site 262543007221 Q-loop/lid; other site 262543007222 ABC transporter signature motif; other site 262543007223 Walker B; other site 262543007224 D-loop; other site 262543007225 H-loop/switch region; other site 262543007226 NIL domain; Region: NIL; pfam09383 262543007227 cystathionine beta-lyase; Provisional; Region: PRK07671 262543007228 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262543007229 homodimer interface [polypeptide binding]; other site 262543007230 substrate-cofactor binding pocket; other site 262543007231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543007232 catalytic residue [active] 262543007233 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 262543007234 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 262543007235 dimer interface [polypeptide binding]; other site 262543007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543007237 catalytic residue [active] 262543007238 S-ribosylhomocysteinase; Provisional; Region: PRK02260 262543007239 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262543007240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543007241 S-adenosylmethionine binding site [chemical binding]; other site 262543007242 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262543007243 catalytic residues [active] 262543007244 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 262543007245 lipoyl attachment site [posttranslational modification]; other site 262543007246 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 262543007247 ArsC family; Region: ArsC; pfam03960 262543007248 putative ArsC-like catalytic residues; other site 262543007249 putative TRX-like catalytic residues [active] 262543007250 DinB superfamily; Region: DinB_2; pfam12867 262543007251 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 262543007252 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262543007253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262543007254 active site 262543007255 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 262543007256 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262543007257 dimer interface [polypeptide binding]; other site 262543007258 active site 262543007259 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262543007260 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 262543007261 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262543007262 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262543007263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262543007264 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262543007265 substrate binding site [chemical binding]; other site 262543007266 oxyanion hole (OAH) forming residues; other site 262543007267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262543007268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543007269 S-adenosylmethionine binding site [chemical binding]; other site 262543007270 Proline dehydrogenase; Region: Pro_dh; cl03282 262543007271 Uncharacterized conserved protein [Function unknown]; Region: COG0398 262543007272 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543007273 Haemolysin-III related; Region: HlyIII; cl03831 262543007274 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 262543007275 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 262543007276 metal binding site [ion binding]; metal-binding site 262543007277 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 262543007278 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 262543007279 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 262543007280 substrate binding site [chemical binding]; other site 262543007281 glutamase interaction surface [polypeptide binding]; other site 262543007282 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 262543007283 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 262543007284 catalytic residues [active] 262543007285 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 262543007286 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 262543007287 putative active site [active] 262543007288 oxyanion strand; other site 262543007289 catalytic triad [active] 262543007290 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 262543007291 putative active site pocket [active] 262543007292 4-fold oligomerization interface [polypeptide binding]; other site 262543007293 metal binding residues [ion binding]; metal-binding site 262543007294 3-fold/trimer interface [polypeptide binding]; other site 262543007295 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 262543007296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262543007297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543007298 homodimer interface [polypeptide binding]; other site 262543007299 catalytic residue [active] 262543007300 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 262543007301 histidinol dehydrogenase; Region: hisD; TIGR00069 262543007302 NAD binding site [chemical binding]; other site 262543007303 dimerization interface [polypeptide binding]; other site 262543007304 product binding site; other site 262543007305 substrate binding site [chemical binding]; other site 262543007306 zinc binding site [ion binding]; other site 262543007307 catalytic residues [active] 262543007308 ATP phosphoribosyltransferase; Region: HisG; cl15266 262543007309 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 262543007310 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 262543007311 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262543007312 motif 1; other site 262543007313 dimer interface [polypeptide binding]; other site 262543007314 active site 262543007315 motif 2; other site 262543007316 motif 3; other site 262543007317 histidinol-phosphatase; Reviewed; Region: PRK08123 262543007318 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 262543007319 active site 262543007320 dimer interface [polypeptide binding]; other site 262543007321 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 262543007322 tetramer interface [polypeptide binding]; other site 262543007323 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 262543007324 active site 262543007325 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 262543007326 active site 262543007327 dimer interface [polypeptide binding]; other site 262543007328 magnesium binding site [ion binding]; other site 262543007329 Predicted transcriptional regulators [Transcription]; Region: COG1733 262543007330 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 262543007331 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543007332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007333 Coenzyme A binding pocket [chemical binding]; other site 262543007334 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 262543007335 DNA methylase; Region: N6_N4_Mtase; pfam01555 262543007336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543007337 non-specific DNA binding site [nucleotide binding]; other site 262543007338 salt bridge; other site 262543007339 sequence-specific DNA binding site [nucleotide binding]; other site 262543007340 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 262543007341 AIPR protein; Region: AIPR; pfam10592 262543007342 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 262543007343 SmpB-tmRNA interface; other site 262543007344 ribonuclease R; Region: RNase_R; TIGR02063 262543007345 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 262543007346 RNB domain; Region: RNB; pfam00773 262543007347 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 262543007348 RNA binding site [nucleotide binding]; other site 262543007349 Esterase/lipase [General function prediction only]; Region: COG1647 262543007350 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 262543007351 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 262543007352 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 262543007353 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 262543007354 ligand binding site [chemical binding]; other site 262543007355 dimerization interface [polypeptide binding]; other site 262543007356 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262543007357 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 262543007358 TM-ABC transporter signature motif; other site 262543007359 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 262543007360 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 262543007361 Walker A/P-loop; other site 262543007362 ATP binding site [chemical binding]; other site 262543007363 Q-loop/lid; other site 262543007364 ABC transporter signature motif; other site 262543007365 Walker B; other site 262543007366 D-loop; other site 262543007367 H-loop/switch region; other site 262543007368 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 262543007369 D-ribose pyranase; Provisional; Region: PRK11797 262543007370 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262543007371 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 262543007372 substrate binding site [chemical binding]; other site 262543007373 dimer interface [polypeptide binding]; other site 262543007374 ATP binding site [chemical binding]; other site 262543007375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262543007376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262543007377 DNA binding site [nucleotide binding] 262543007378 domain linker motif; other site 262543007379 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 262543007380 dimerization interface [polypeptide binding]; other site 262543007381 ligand binding site [chemical binding]; other site 262543007382 sodium binding site [ion binding]; other site 262543007383 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 262543007384 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 262543007385 homodimer interface [polypeptide binding]; other site 262543007386 putative substrate binding pocket [chemical binding]; other site 262543007387 diiron center [ion binding]; other site 262543007388 enolase; Provisional; Region: eno; PRK00077 262543007389 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 262543007390 dimer interface [polypeptide binding]; other site 262543007391 metal binding site [ion binding]; metal-binding site 262543007392 substrate binding pocket [chemical binding]; other site 262543007393 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 262543007394 phosphoglyceromutase; Provisional; Region: PRK05434 262543007395 triosephosphate isomerase; Provisional; Region: PRK14567 262543007396 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 262543007397 substrate binding site [chemical binding]; other site 262543007398 dimer interface [polypeptide binding]; other site 262543007399 catalytic triad [active] 262543007400 Phosphoglycerate kinase; Region: PGK; pfam00162 262543007401 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 262543007402 substrate binding site [chemical binding]; other site 262543007403 hinge regions; other site 262543007404 ADP binding site [chemical binding]; other site 262543007405 catalytic site [active] 262543007406 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 262543007407 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 262543007408 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 262543007409 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 262543007410 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 262543007411 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 262543007412 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 262543007413 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 262543007414 Clp protease; Region: CLP_protease; pfam00574 262543007415 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 262543007416 oligomer interface [polypeptide binding]; other site 262543007417 active site residues [active] 262543007418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 262543007419 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 262543007420 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 262543007421 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 262543007422 phosphate binding site [ion binding]; other site 262543007423 putative substrate binding pocket [chemical binding]; other site 262543007424 dimer interface [polypeptide binding]; other site 262543007425 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 262543007426 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 262543007427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543007428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543007429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543007430 binding surface 262543007431 TPR motif; other site 262543007432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543007433 binding surface 262543007434 TPR motif; other site 262543007435 Kinase associated protein B; Region: KapB; pfam08810 262543007436 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 262543007437 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 262543007438 trimer interface [polypeptide binding]; other site 262543007439 active site 262543007440 substrate binding site [chemical binding]; other site 262543007441 CoA binding site [chemical binding]; other site 262543007442 pyrophosphatase PpaX; Provisional; Region: PRK13288 262543007443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543007444 motif II; other site 262543007445 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 262543007446 HPr kinase/phosphorylase; Provisional; Region: PRK05428 262543007447 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 262543007448 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 262543007449 Hpr binding site; other site 262543007450 active site 262543007451 homohexamer subunit interaction site [polypeptide binding]; other site 262543007452 Uncharacterized conserved protein [Function unknown]; Region: COG3595 262543007453 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 262543007454 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 262543007455 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 262543007456 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 262543007457 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 262543007458 excinuclease ABC subunit B; Provisional; Region: PRK05298 262543007459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543007460 ATP binding site [chemical binding]; other site 262543007461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543007462 nucleotide binding region [chemical binding]; other site 262543007463 ATP-binding site [chemical binding]; other site 262543007464 Ultra-violet resistance protein B; Region: UvrB; pfam12344 262543007465 UvrB/uvrC motif; Region: UVR; pfam02151 262543007466 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 262543007467 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 262543007468 C-terminal peptidase (prc); Region: prc; TIGR00225 262543007469 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 262543007470 protein binding site [polypeptide binding]; other site 262543007471 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 262543007472 Catalytic dyad [active] 262543007473 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262543007474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 262543007475 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262543007476 Peptidase family M23; Region: Peptidase_M23; pfam01551 262543007477 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 262543007478 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 262543007479 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 262543007480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262543007481 Walker A/P-loop; other site 262543007482 ATP binding site [chemical binding]; other site 262543007483 Q-loop/lid; other site 262543007484 ABC transporter signature motif; other site 262543007485 Walker B; other site 262543007486 D-loop; other site 262543007487 H-loop/switch region; other site 262543007488 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 262543007489 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 262543007490 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543007491 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543007492 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543007493 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543007494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007495 Coenzyme A binding pocket [chemical binding]; other site 262543007496 peptide chain release factor 2; Validated; Region: prfB; PRK00578 262543007497 This domain is found in peptide chain release factors; Region: PCRF; smart00937 262543007498 RF-1 domain; Region: RF-1; pfam00472 262543007499 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 262543007500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 262543007501 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 262543007502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 262543007503 nucleotide binding region [chemical binding]; other site 262543007504 ATP-binding site [chemical binding]; other site 262543007505 SEC-C motif; Region: SEC-C; pfam02810 262543007506 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 262543007507 30S subunit binding site; other site 262543007508 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262543007509 DNA-binding site [nucleotide binding]; DNA binding site 262543007510 RNA-binding motif; other site 262543007511 ComK protein; Region: ComK; pfam06338 262543007512 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 262543007513 Flagellar protein FliS; Region: FliS; cl00654 262543007514 flagellin; Provisional; Region: PRK12804 262543007515 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 262543007516 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 262543007517 Protein of unknown function (DUF327); Region: DUF327; pfam03885 262543007518 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 262543007519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 262543007520 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543007521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543007522 metal binding site [ion binding]; metal-binding site 262543007523 active site 262543007524 I-site; other site 262543007525 Flagellar protein FliS; Region: FliS; cl00654 262543007526 flagellar capping protein; Validated; Region: fliD; PRK07737 262543007527 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 262543007528 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 262543007529 FlaG protein; Region: FlaG; cl00591 262543007530 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 262543007531 flagellin; Provisional; Region: PRK12804 262543007532 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 262543007533 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 262543007534 HAMP domain; Region: HAMP; pfam00672 262543007535 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543007536 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543007537 dimer interface [polypeptide binding]; other site 262543007538 putative CheW interface [polypeptide binding]; other site 262543007539 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262543007540 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 262543007541 peptide binding site [polypeptide binding]; other site 262543007542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007543 Coenzyme A binding pocket [chemical binding]; other site 262543007544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262543007545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543007546 Coenzyme A binding pocket [chemical binding]; other site 262543007547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543007548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543007549 dimerization interface [polypeptide binding]; other site 262543007550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543007551 dimer interface [polypeptide binding]; other site 262543007552 phosphorylation site [posttranslational modification] 262543007553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543007554 ATP binding site [chemical binding]; other site 262543007555 Mg2+ binding site [ion binding]; other site 262543007556 G-X-G motif; other site 262543007557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543007558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543007559 active site 262543007560 phosphorylation site [posttranslational modification] 262543007561 intermolecular recognition site; other site 262543007562 dimerization interface [polypeptide binding]; other site 262543007563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543007564 DNA binding site [nucleotide binding] 262543007565 PAS domain S-box; Region: sensory_box; TIGR00229 262543007566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543007567 putative active site [active] 262543007568 heme pocket [chemical binding]; other site 262543007569 PAS domain S-box; Region: sensory_box; TIGR00229 262543007570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543007571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543007572 metal binding site [ion binding]; metal-binding site 262543007573 active site 262543007574 I-site; other site 262543007575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543007576 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543007577 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543007578 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543007579 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 262543007580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262543007581 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262543007582 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 262543007583 substrate binding pocket [chemical binding]; other site 262543007584 substrate-Mg2+ binding site; other site 262543007585 aspartate-rich region 1; other site 262543007586 aspartate-rich region 2; other site 262543007587 carbon storage regulator; Provisional; Region: PRK01712 262543007588 FliW protein; Region: FliW; cl00740 262543007589 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 262543007590 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 262543007591 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 262543007592 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 262543007593 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 262543007594 FlgN protein; Region: FlgN; pfam05130 262543007595 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 262543007596 flagellar operon protein TIGR03826; Region: YvyF 262543007597 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 262543007598 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543007599 active site 262543007600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543007601 ATP binding site [chemical binding]; other site 262543007602 putative Mg++ binding site [ion binding]; other site 262543007603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543007604 nucleotide binding region [chemical binding]; other site 262543007605 ATP-binding site [chemical binding]; other site 262543007606 EDD domain protein, DegV family; Region: DegV; TIGR00762 262543007607 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 262543007608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262543007609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543007610 active site 262543007611 phosphorylation site [posttranslational modification] 262543007612 intermolecular recognition site; other site 262543007613 dimerization interface [polypeptide binding]; other site 262543007614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262543007615 DNA binding residues [nucleotide binding] 262543007616 dimerization interface [polypeptide binding]; other site 262543007617 Sensor protein DegS; Region: DegS; pfam05384 262543007618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262543007619 Histidine kinase; Region: HisKA_3; pfam07730 262543007620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543007621 ATP binding site [chemical binding]; other site 262543007622 Mg2+ binding site [ion binding]; other site 262543007623 G-X-G motif; other site 262543007624 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 262543007625 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 262543007626 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 262543007627 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262543007628 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 262543007629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 262543007630 Coenzyme A binding pocket [chemical binding]; other site 262543007631 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 262543007632 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 262543007633 Chromate transporter; Region: Chromate_transp; pfam02417 262543007634 Predicted membrane protein [Function unknown]; Region: COG2311 262543007635 Protein of unknown function (DUF418); Region: DUF418; cl12135 262543007636 Protein of unknown function (DUF418); Region: DUF418; pfam04235 262543007637 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 262543007638 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 262543007639 Mg++ binding site [ion binding]; other site 262543007640 putative catalytic motif [active] 262543007641 substrate binding site [chemical binding]; other site 262543007642 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007643 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007644 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007645 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 262543007646 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262543007647 active site 262543007648 metal binding site [ion binding]; metal-binding site 262543007649 beta-phosphoglucomutase; Region: bPGM; TIGR01990 262543007650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543007651 motif II; other site 262543007652 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 262543007653 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 262543007654 nucleotide binding region [chemical binding]; other site 262543007655 helicase superfamily c-terminal domain; Region: HELICc; smart00490 262543007656 ATP-binding site [chemical binding]; other site 262543007657 Asp23 family; Region: Asp23; pfam03780 262543007658 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 262543007659 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262543007660 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 262543007661 active site 262543007662 catalytic triad [active] 262543007663 oxyanion hole [active] 262543007664 Predicted esterase [General function prediction only]; Region: COG0400 262543007665 putative hydrolase; Provisional; Region: PRK11460 262543007666 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 262543007667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543007668 Zn binding site [ion binding]; other site 262543007669 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 262543007670 Zn binding site [ion binding]; other site 262543007671 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 262543007672 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 262543007673 Walker A/P-loop; other site 262543007674 ATP binding site [chemical binding]; other site 262543007675 Q-loop/lid; other site 262543007676 ABC transporter signature motif; other site 262543007677 Walker B; other site 262543007678 D-loop; other site 262543007679 H-loop/switch region; other site 262543007680 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 262543007681 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 262543007682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543007683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543007684 non-specific DNA binding site [nucleotide binding]; other site 262543007685 salt bridge; other site 262543007686 sequence-specific DNA binding site [nucleotide binding]; other site 262543007687 FtsX-like permease family; Region: FtsX; pfam02687 262543007688 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262543007689 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262543007690 Walker A/P-loop; other site 262543007691 ATP binding site [chemical binding]; other site 262543007692 Q-loop/lid; other site 262543007693 ABC transporter signature motif; other site 262543007694 Walker B; other site 262543007695 D-loop; other site 262543007696 H-loop/switch region; other site 262543007697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543007698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 262543007699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543007700 ATP binding site [chemical binding]; other site 262543007701 Mg2+ binding site [ion binding]; other site 262543007702 G-X-G motif; other site 262543007703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543007704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543007705 active site 262543007706 phosphorylation site [posttranslational modification] 262543007707 intermolecular recognition site; other site 262543007708 dimerization interface [polypeptide binding]; other site 262543007709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543007710 DNA binding site [nucleotide binding] 262543007711 FtsX-like permease family; Region: FtsX; pfam02687 262543007712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262543007713 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262543007714 Walker A/P-loop; other site 262543007715 ATP binding site [chemical binding]; other site 262543007716 Q-loop/lid; other site 262543007717 ABC transporter signature motif; other site 262543007718 Walker B; other site 262543007719 D-loop; other site 262543007720 H-loop/switch region; other site 262543007721 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 262543007722 HPr interaction site; other site 262543007723 glycerol kinase (GK) interaction site [polypeptide binding]; other site 262543007724 active site 262543007725 phosphorylation site [posttranslational modification] 262543007726 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 262543007727 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 262543007728 active site 262543007729 Zn binding site [ion binding]; other site 262543007730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543007731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543007732 metal binding site [ion binding]; metal-binding site 262543007733 active site 262543007734 I-site; other site 262543007735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543007736 FOG: CBS domain [General function prediction only]; Region: COG0517 262543007737 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 262543007738 Cache domain; Region: Cache_1; pfam02743 262543007739 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543007740 dimerization interface [polypeptide binding]; other site 262543007741 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 262543007742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262543007743 dimer interface [polypeptide binding]; other site 262543007744 putative CheW interface [polypeptide binding]; other site 262543007745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262543007746 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543007747 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543007748 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 262543007749 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 262543007750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543007751 S-adenosylmethionine binding site [chemical binding]; other site 262543007752 putative lipid kinase; Reviewed; Region: PRK13337 262543007753 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 262543007754 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 262543007755 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 262543007756 GatB domain; Region: GatB_Yqey; smart00845 262543007757 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 262543007758 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 262543007759 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 262543007760 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 262543007761 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 262543007762 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 262543007763 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 262543007764 Na binding site [ion binding]; other site 262543007765 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 262543007766 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 262543007767 Glutamate binding site [chemical binding]; other site 262543007768 homodimer interface [polypeptide binding]; other site 262543007769 NAD binding site [chemical binding]; other site 262543007770 catalytic residues [active] 262543007771 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 262543007772 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 262543007773 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 262543007774 catalytic triad [active] 262543007775 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262543007776 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 262543007777 peptide binding site [polypeptide binding]; other site 262543007778 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543007779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543007780 metal binding site [ion binding]; metal-binding site 262543007781 active site 262543007782 I-site; other site 262543007783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 262543007784 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 262543007785 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 262543007786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 262543007787 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 262543007788 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 262543007789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 262543007790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543007791 dimer interface [polypeptide binding]; other site 262543007792 conserved gate region; other site 262543007793 putative PBP binding loops; other site 262543007794 ABC-ATPase subunit interface; other site 262543007795 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 262543007796 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 262543007797 Walker A/P-loop; other site 262543007798 ATP binding site [chemical binding]; other site 262543007799 Q-loop/lid; other site 262543007800 ABC transporter signature motif; other site 262543007801 Walker B; other site 262543007802 D-loop; other site 262543007803 H-loop/switch region; other site 262543007804 TOBE domain; Region: TOBE_2; pfam08402 262543007805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543007806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543007807 non-specific DNA binding site [nucleotide binding]; other site 262543007808 salt bridge; other site 262543007809 sequence-specific DNA binding site [nucleotide binding]; other site 262543007810 Cupin domain; Region: Cupin_2; pfam07883 262543007811 EDD domain protein, DegV family; Region: DegV; TIGR00762 262543007812 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 262543007813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 262543007814 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 262543007815 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 262543007816 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 262543007817 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543007818 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543007819 metal binding site [ion binding]; metal-binding site 262543007820 active site 262543007821 I-site; other site 262543007822 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543007823 Putative zinc-finger; Region: zf-HC2; pfam13490 262543007824 Anti-sigma-K factor rskA; Region: RskA; pfam10099 262543007825 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 262543007826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543007827 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543007828 DNA binding residues [nucleotide binding] 262543007829 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 262543007830 putative homodimer interface [polypeptide binding]; other site 262543007831 putative homotetramer interface [polypeptide binding]; other site 262543007832 putative metal binding site [ion binding]; other site 262543007833 putative homodimer-homodimer interface [polypeptide binding]; other site 262543007834 putative allosteric switch controlling residues; other site 262543007835 Uncharacterized conserved protein [Function unknown]; Region: COG2353 262543007836 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 262543007837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262543007838 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 262543007839 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 262543007840 Ca binding site [ion binding]; other site 262543007841 active site 262543007842 catalytic site [active] 262543007843 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 262543007844 transaminase; Reviewed; Region: PRK08068 262543007845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262543007846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543007847 homodimer interface [polypeptide binding]; other site 262543007848 catalytic residue [active] 262543007849 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 262543007850 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 262543007851 Walker A/P-loop; other site 262543007852 ATP binding site [chemical binding]; other site 262543007853 Q-loop/lid; other site 262543007854 ABC transporter signature motif; other site 262543007855 Walker B; other site 262543007856 D-loop; other site 262543007857 H-loop/switch region; other site 262543007858 NIL domain; Region: NIL; pfam09383 262543007859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543007860 dimer interface [polypeptide binding]; other site 262543007861 conserved gate region; other site 262543007862 ABC-ATPase subunit interface; other site 262543007863 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 262543007864 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 262543007865 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 262543007866 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 262543007867 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 262543007868 Fn3 associated; Region: Fn3_assoc; pfam13287 262543007869 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 262543007870 generic binding surface II; other site 262543007871 generic binding surface I; other site 262543007872 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 262543007873 putative active site [active] 262543007874 putative catalytic site [active] 262543007875 putative Mg binding site IVb [ion binding]; other site 262543007876 putative phosphate binding site [ion binding]; other site 262543007877 putative DNA binding site [nucleotide binding]; other site 262543007878 putative Mg binding site IVa [ion binding]; other site 262543007879 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 262543007880 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 262543007881 catalytic residues [active] 262543007882 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007883 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007884 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007885 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 262543007886 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543007887 Bacterial SH3 domain; Region: SH3_3; cl17532 262543007888 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 262543007889 Lysozyme subfamily 2; Region: LYZ2; smart00047 262543007890 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 262543007891 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 262543007892 Ligand Binding Site [chemical binding]; other site 262543007893 K+-transporting ATPase, c chain; Region: KdpC; cl00944 262543007894 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 262543007895 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262543007896 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 262543007897 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 262543007898 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 262543007899 catalytic residues [active] 262543007900 dimer interface [polypeptide binding]; other site 262543007901 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 262543007902 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543007903 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543007904 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543007905 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543007906 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 262543007907 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262543007908 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 262543007909 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 262543007910 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 262543007911 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 262543007912 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262543007913 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 262543007914 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 262543007915 inhibitor-cofactor binding pocket; inhibition site 262543007916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262543007917 catalytic residue [active] 262543007918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 262543007919 Bacterial sugar transferase; Region: Bac_transf; pfam02397 262543007920 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 262543007921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543007922 putative ADP-binding pocket [chemical binding]; other site 262543007923 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262543007924 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 262543007925 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262543007926 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 262543007927 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 262543007928 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 262543007929 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262543007930 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 262543007931 putative NAD(P) binding site [chemical binding]; other site 262543007932 active site 262543007933 putative substrate binding site [chemical binding]; other site 262543007934 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 262543007935 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 262543007936 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 262543007937 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 262543007938 NAD(P) binding site [chemical binding]; other site 262543007939 homodimer interface [polypeptide binding]; other site 262543007940 substrate binding site [chemical binding]; other site 262543007941 active site 262543007942 Chain length determinant protein; Region: Wzz; cl15801 262543007943 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 262543007944 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 262543007945 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 262543007946 VanZ like family; Region: VanZ; pfam04892 262543007947 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543007948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543007949 non-specific DNA binding site [nucleotide binding]; other site 262543007950 salt bridge; other site 262543007951 sequence-specific DNA binding site [nucleotide binding]; other site 262543007952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262543007953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543007954 non-specific DNA binding site [nucleotide binding]; other site 262543007955 salt bridge; other site 262543007956 sequence-specific DNA binding site [nucleotide binding]; other site 262543007957 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 262543007958 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 262543007959 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 262543007960 active site 262543007961 tetramer interface; other site 262543007962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 262543007963 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 262543007964 Walker A/P-loop; other site 262543007965 ATP binding site [chemical binding]; other site 262543007966 Q-loop/lid; other site 262543007967 ABC transporter signature motif; other site 262543007968 Walker B; other site 262543007969 D-loop; other site 262543007970 H-loop/switch region; other site 262543007971 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 262543007972 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 262543007973 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 262543007974 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 262543007975 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262543007976 active site 262543007977 metal binding site [ion binding]; metal-binding site 262543007978 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 262543007979 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 262543007980 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 262543007981 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 262543007982 Predicted integral membrane protein [Function unknown]; Region: COG5652 262543007983 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 262543007984 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 262543007985 putative di-iron ligands [ion binding]; other site 262543007986 Domain of unknown function (DUF955); Region: DUF955; cl01076 262543007987 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262543007988 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 262543007989 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 262543007990 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 262543007991 [2Fe-2S] cluster binding site [ion binding]; other site 262543007992 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 262543007993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543007994 putative substrate translocation pore; other site 262543007995 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 262543007996 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 262543007997 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 262543007998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543007999 HAMP domain; Region: HAMP; pfam00672 262543008000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008001 dimer interface [polypeptide binding]; other site 262543008002 phosphorylation site [posttranslational modification] 262543008003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008004 ATP binding site [chemical binding]; other site 262543008005 Mg2+ binding site [ion binding]; other site 262543008006 G-X-G motif; other site 262543008007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543008008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543008009 active site 262543008010 phosphorylation site [posttranslational modification] 262543008011 intermolecular recognition site; other site 262543008012 dimerization interface [polypeptide binding]; other site 262543008013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543008014 DNA binding site [nucleotide binding] 262543008015 Fn3 associated; Region: Fn3_assoc; pfam13287 262543008016 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 262543008017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543008018 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543008019 Probable transposase; Region: OrfB_IS605; pfam01385 262543008020 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543008021 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 262543008022 Double zinc ribbon; Region: DZR; pfam12773 262543008023 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 262543008024 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 262543008025 Double zinc ribbon; Region: DZR; pfam12773 262543008026 Predicted membrane protein [Function unknown]; Region: COG4640 262543008027 PAS domain; Region: PAS_9; pfam13426 262543008028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 262543008029 putative active site [active] 262543008030 heme pocket [chemical binding]; other site 262543008031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543008032 PAS fold; Region: PAS_3; pfam08447 262543008033 putative active site [active] 262543008034 heme pocket [chemical binding]; other site 262543008035 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543008036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543008037 metal binding site [ion binding]; metal-binding site 262543008038 active site 262543008039 I-site; other site 262543008040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543008041 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 262543008042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543008043 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 262543008044 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262543008045 active site 262543008046 DNA binding site [nucleotide binding] 262543008047 Int/Topo IB signature motif; other site 262543008048 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 262543008049 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262543008050 active site 262543008051 DNA binding site [nucleotide binding] 262543008052 Int/Topo IB signature motif; other site 262543008053 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 262543008054 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 262543008055 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262543008056 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 262543008057 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262543008058 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 262543008059 putative NAD(P) binding site [chemical binding]; other site 262543008060 active site 262543008061 putative substrate binding site [chemical binding]; other site 262543008062 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 262543008063 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 262543008064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543008065 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 262543008066 putative ADP-binding pocket [chemical binding]; other site 262543008067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543008068 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 262543008069 putative ADP-binding pocket [chemical binding]; other site 262543008070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262543008071 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 262543008072 putative ADP-binding pocket [chemical binding]; other site 262543008073 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 262543008074 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 262543008075 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262543008076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543008077 NAD(P) binding site [chemical binding]; other site 262543008078 active site 262543008079 Bacterial sugar transferase; Region: Bac_transf; pfam02397 262543008080 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 262543008081 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 262543008082 NAD(P) binding site [chemical binding]; other site 262543008083 homodimer interface [polypeptide binding]; other site 262543008084 substrate binding site [chemical binding]; other site 262543008085 active site 262543008086 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 262543008087 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 262543008088 active site 262543008089 tetramer interface; other site 262543008090 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 262543008091 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 262543008092 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262543008093 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 262543008094 Chain length determinant protein; Region: Wzz; cl15801 262543008095 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262543008096 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 262543008097 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 262543008098 active site 262543008099 catalytic triad [active] 262543008100 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 262543008101 active site 262543008102 catalytic triad [active] 262543008103 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262543008104 Helix-turn-helix domain; Region: HTH_38; pfam13936 262543008105 Integrase core domain; Region: rve; pfam00665 262543008106 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 262543008107 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 262543008108 active site 262543008109 catalytic site [active] 262543008110 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 262543008111 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 262543008112 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262543008113 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262543008114 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 262543008115 Pirin; Region: Pirin; pfam02678 262543008116 Pirin-related protein [General function prediction only]; Region: COG1741 262543008117 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 262543008118 Helix-turn-helix domain; Region: HTH_17; pfam12728 262543008119 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 262543008120 dimerization interface [polypeptide binding]; other site 262543008121 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 262543008122 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 262543008123 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 262543008124 active site 262543008125 putative catalytic site [active] 262543008126 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 262543008127 MarR family; Region: MarR_2; cl17246 262543008128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 262543008129 Domain of unknown function DUF20; Region: UPF0118; pfam01594 262543008130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 262543008131 GAF domain; Region: GAF_3; pfam13492 262543008132 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 262543008133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008134 dimer interface [polypeptide binding]; other site 262543008135 phosphorylation site [posttranslational modification] 262543008136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008137 ATP binding site [chemical binding]; other site 262543008138 Mg2+ binding site [ion binding]; other site 262543008139 G-X-G motif; other site 262543008140 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 262543008141 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262543008142 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 262543008143 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 262543008144 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 262543008145 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 262543008146 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 262543008147 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 262543008148 PAS domain S-box; Region: sensory_box; TIGR00229 262543008149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543008150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543008151 metal binding site [ion binding]; metal-binding site 262543008152 active site 262543008153 I-site; other site 262543008154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543008155 drug efflux system protein MdtG; Provisional; Region: PRK09874 262543008156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543008157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543008158 putative substrate translocation pore; other site 262543008159 rod shape-determining protein Mbl; Provisional; Region: PRK13928 262543008160 MreB and similar proteins; Region: MreB_like; cd10225 262543008161 nucleotide binding site [chemical binding]; other site 262543008162 Mg binding site [ion binding]; other site 262543008163 putative protofilament interaction site [polypeptide binding]; other site 262543008164 RodZ interaction site [polypeptide binding]; other site 262543008165 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 262543008166 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 262543008167 hinge; other site 262543008168 active site 262543008169 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 262543008170 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 262543008171 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 262543008172 gamma subunit interface [polypeptide binding]; other site 262543008173 epsilon subunit interface [polypeptide binding]; other site 262543008174 LBP interface [polypeptide binding]; other site 262543008175 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 262543008176 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 262543008177 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 262543008178 alpha subunit interaction interface [polypeptide binding]; other site 262543008179 Walker A motif; other site 262543008180 ATP binding site [chemical binding]; other site 262543008181 Walker B motif; other site 262543008182 inhibitor binding site; inhibition site 262543008183 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262543008184 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 262543008185 core domain interface [polypeptide binding]; other site 262543008186 delta subunit interface [polypeptide binding]; other site 262543008187 epsilon subunit interface [polypeptide binding]; other site 262543008188 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 262543008189 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 262543008190 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 262543008191 beta subunit interaction interface [polypeptide binding]; other site 262543008192 Walker A motif; other site 262543008193 ATP binding site [chemical binding]; other site 262543008194 Walker B motif; other site 262543008195 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262543008196 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 262543008197 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 262543008198 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 262543008199 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 262543008200 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 262543008201 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 262543008202 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 262543008203 ATP synthase I chain; Region: ATP_synt_I; pfam03899 262543008204 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 262543008205 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 262543008206 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 262543008207 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 262543008208 active site 262543008209 homodimer interface [polypeptide binding]; other site 262543008210 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262543008211 active site 262543008212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262543008213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262543008214 Walker A/P-loop; other site 262543008215 ATP binding site [chemical binding]; other site 262543008216 Q-loop/lid; other site 262543008217 ABC transporter signature motif; other site 262543008218 Walker B; other site 262543008219 D-loop; other site 262543008220 H-loop/switch region; other site 262543008221 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 262543008222 FtsX-like permease family; Region: FtsX; pfam02687 262543008223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543008224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543008225 dimerization interface [polypeptide binding]; other site 262543008226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008227 dimer interface [polypeptide binding]; other site 262543008228 phosphorylation site [posttranslational modification] 262543008229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008230 ATP binding site [chemical binding]; other site 262543008231 Mg2+ binding site [ion binding]; other site 262543008232 G-X-G motif; other site 262543008233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543008234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543008235 active site 262543008236 phosphorylation site [posttranslational modification] 262543008237 intermolecular recognition site; other site 262543008238 dimerization interface [polypeptide binding]; other site 262543008239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543008240 DNA binding site [nucleotide binding] 262543008241 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 262543008242 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 262543008243 dimer interface [polypeptide binding]; other site 262543008244 active site 262543008245 glycine-pyridoxal phosphate binding site [chemical binding]; other site 262543008246 folate binding site [chemical binding]; other site 262543008247 hypothetical protein; Provisional; Region: PRK13690 262543008248 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 262543008249 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 262543008250 Low molecular weight phosphatase family; Region: LMWPc; cd00115 262543008251 active site 262543008252 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 262543008253 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 262543008254 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 262543008255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543008256 S-adenosylmethionine binding site [chemical binding]; other site 262543008257 peptide chain release factor 1; Validated; Region: prfA; PRK00591 262543008258 This domain is found in peptide chain release factors; Region: PCRF; smart00937 262543008259 RF-1 domain; Region: RF-1; pfam00472 262543008260 AAA domain; Region: AAA_33; pfam13671 262543008261 AAA domain; Region: AAA_17; pfam13207 262543008262 Predicted transcriptional regulators [Transcription]; Region: COG1725 262543008263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543008264 DNA-binding site [nucleotide binding]; DNA binding site 262543008265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262543008266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262543008267 Walker A/P-loop; other site 262543008268 ATP binding site [chemical binding]; other site 262543008269 Q-loop/lid; other site 262543008270 ABC transporter signature motif; other site 262543008271 Walker B; other site 262543008272 D-loop; other site 262543008273 H-loop/switch region; other site 262543008274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543008275 DNA-binding site [nucleotide binding]; DNA binding site 262543008276 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 262543008277 UTRA domain; Region: UTRA; pfam07702 262543008278 PAS domain S-box; Region: sensory_box; TIGR00229 262543008279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543008280 putative active site [active] 262543008281 heme pocket [chemical binding]; other site 262543008282 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 262543008283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543008284 putative active site [active] 262543008285 heme pocket [chemical binding]; other site 262543008286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543008287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543008288 metal binding site [ion binding]; metal-binding site 262543008289 active site 262543008290 I-site; other site 262543008291 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543008292 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 262543008293 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543008294 active site turn [active] 262543008295 phosphorylation site [posttranslational modification] 262543008296 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543008297 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 262543008298 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 262543008299 Ca binding site [ion binding]; other site 262543008300 active site 262543008301 catalytic site [active] 262543008302 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 262543008303 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 262543008304 amino acid carrier protein; Region: agcS; TIGR00835 262543008305 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 262543008306 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 262543008307 dimer interface [polypeptide binding]; other site 262543008308 Alkaline phosphatase homologues; Region: alkPPc; smart00098 262543008309 active site 262543008310 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 262543008311 PAS domain S-box; Region: sensory_box; TIGR00229 262543008312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543008313 putative active site [active] 262543008314 heme pocket [chemical binding]; other site 262543008315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543008316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543008317 metal binding site [ion binding]; metal-binding site 262543008318 active site 262543008319 I-site; other site 262543008320 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262543008321 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 262543008322 homopentamer interface [polypeptide binding]; other site 262543008323 active site 262543008324 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 262543008325 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 262543008326 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 262543008327 dimerization interface [polypeptide binding]; other site 262543008328 active site 262543008329 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 262543008330 Lumazine binding domain; Region: Lum_binding; pfam00677 262543008331 Lumazine binding domain; Region: Lum_binding; pfam00677 262543008332 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 262543008333 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 262543008334 catalytic motif [active] 262543008335 Zn binding site [ion binding]; other site 262543008336 RibD C-terminal domain; Region: RibD_C; pfam01872 262543008337 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 262543008338 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 262543008339 metal binding site [ion binding]; metal-binding site 262543008340 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 262543008341 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 262543008342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262543008343 dimer interface [polypeptide binding]; other site 262543008344 conserved gate region; other site 262543008345 ABC-ATPase subunit interface; other site 262543008346 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 262543008347 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 262543008348 Walker A/P-loop; other site 262543008349 ATP binding site [chemical binding]; other site 262543008350 Q-loop/lid; other site 262543008351 ABC transporter signature motif; other site 262543008352 Walker B; other site 262543008353 D-loop; other site 262543008354 H-loop/switch region; other site 262543008355 NIL domain; Region: NIL; pfam09383 262543008356 Esterase/lipase [General function prediction only]; Region: COG1647 262543008357 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262543008358 thymidine kinase; Provisional; Region: PRK04296 262543008359 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262543008360 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543008361 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 262543008362 transcription termination factor Rho; Provisional; Region: rho; PRK09376 262543008363 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 262543008364 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 262543008365 RNA binding site [nucleotide binding]; other site 262543008366 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 262543008367 multimer interface [polypeptide binding]; other site 262543008368 Walker A motif; other site 262543008369 ATP binding site [chemical binding]; other site 262543008370 Walker B motif; other site 262543008371 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543008372 NlpC/P60 family; Region: NLPC_P60; pfam00877 262543008373 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262543008374 classical (c) SDRs; Region: SDR_c; cd05233 262543008375 NAD(P) binding site [chemical binding]; other site 262543008376 active site 262543008377 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 262543008378 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 262543008379 putative active site [active] 262543008380 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 262543008381 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 262543008382 hinge; other site 262543008383 active site 262543008384 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 262543008385 active site 262543008386 intersubunit interactions; other site 262543008387 catalytic residue [active] 262543008388 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 262543008389 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 262543008390 intersubunit interface [polypeptide binding]; other site 262543008391 active site 262543008392 zinc binding site [ion binding]; other site 262543008393 Na+ binding site [ion binding]; other site 262543008394 Response regulator receiver domain; Region: Response_reg; pfam00072 262543008395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543008396 active site 262543008397 phosphorylation site [posttranslational modification] 262543008398 intermolecular recognition site; other site 262543008399 dimerization interface [polypeptide binding]; other site 262543008400 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 262543008401 CTP synthetase; Validated; Region: pyrG; PRK05380 262543008402 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 262543008403 Catalytic site [active] 262543008404 active site 262543008405 UTP binding site [chemical binding]; other site 262543008406 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 262543008407 active site 262543008408 putative oxyanion hole; other site 262543008409 catalytic triad [active] 262543008410 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 262543008411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543008412 Coenzyme A binding pocket [chemical binding]; other site 262543008413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543008414 dimerization interface [polypeptide binding]; other site 262543008415 putative DNA binding site [nucleotide binding]; other site 262543008416 putative Zn2+ binding site [ion binding]; other site 262543008417 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543008418 Protein of unknown function, DUF606; Region: DUF606; pfam04657 262543008419 Domain of unknown function (DUF336); Region: DUF336; cl01249 262543008420 putative oxidoreductase; Provisional; Region: PRK11579 262543008421 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262543008422 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 262543008423 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 262543008424 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 262543008425 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 262543008426 short chain dehydrogenase; Provisional; Region: PRK08219 262543008427 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 262543008428 NADP binding site [chemical binding]; other site 262543008429 active site 262543008430 steroid binding site; other site 262543008431 Ion channel; Region: Ion_trans_2; pfam07885 262543008432 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 262543008433 MgtE intracellular N domain; Region: MgtE_N; pfam03448 262543008434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 262543008435 Divalent cation transporter; Region: MgtE; pfam01769 262543008436 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 262543008437 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 262543008438 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 262543008439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543008440 dimer interface [polypeptide binding]; other site 262543008441 ABC-ATPase subunit interface; other site 262543008442 putative PBP binding regions; other site 262543008443 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 262543008444 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 262543008445 metal binding site [ion binding]; metal-binding site 262543008446 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 262543008447 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 262543008448 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 262543008449 putative NAD(P) binding site [chemical binding]; other site 262543008450 dimer interface [polypeptide binding]; other site 262543008451 HAMP domain; Region: HAMP; pfam00672 262543008452 dimerization interface [polypeptide binding]; other site 262543008453 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 262543008454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008455 dimer interface [polypeptide binding]; other site 262543008456 phosphorylation site [posttranslational modification] 262543008457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008458 ATP binding site [chemical binding]; other site 262543008459 Mg2+ binding site [ion binding]; other site 262543008460 G-X-G motif; other site 262543008461 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262543008462 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262543008463 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 262543008464 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262543008465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543008466 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543008467 Probable transposase; Region: OrfB_IS605; pfam01385 262543008468 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543008469 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 262543008470 Sulfatase; Region: Sulfatase; pfam00884 262543008471 HEAT repeats; Region: HEAT_2; pfam13646 262543008472 HEAT repeats; Region: HEAT_2; pfam13646 262543008473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543008474 Coenzyme A binding pocket [chemical binding]; other site 262543008475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262543008476 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 262543008477 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 262543008478 ring oligomerisation interface [polypeptide binding]; other site 262543008479 ATP/Mg binding site [chemical binding]; other site 262543008480 stacking interactions; other site 262543008481 hinge regions; other site 262543008482 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 262543008483 oligomerisation interface [polypeptide binding]; other site 262543008484 mobile loop; other site 262543008485 roof hairpin; other site 262543008486 CAAX protease self-immunity; Region: Abi; pfam02517 262543008487 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 262543008488 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 262543008489 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 262543008490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543008491 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262543008492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 262543008493 Walker A/P-loop; other site 262543008494 ATP binding site [chemical binding]; other site 262543008495 Q-loop/lid; other site 262543008496 ABC transporter signature motif; other site 262543008497 Walker B; other site 262543008498 D-loop; other site 262543008499 H-loop/switch region; other site 262543008500 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 262543008501 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 262543008502 putative ligand binding residues [chemical binding]; other site 262543008503 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 262543008504 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543008505 dimer interface [polypeptide binding]; other site 262543008506 putative PBP binding regions; other site 262543008507 ABC-ATPase subunit interface; other site 262543008508 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 262543008509 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262543008510 ABC-ATPase subunit interface; other site 262543008511 dimer interface [polypeptide binding]; other site 262543008512 putative PBP binding regions; other site 262543008513 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 262543008514 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 262543008515 putative active site [active] 262543008516 catalytic triad [active] 262543008517 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 262543008518 PA/protease or protease-like domain interface [polypeptide binding]; other site 262543008519 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 262543008520 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 262543008521 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 262543008522 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 262543008523 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 262543008524 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 262543008525 CoA binding domain; Region: CoA_binding; pfam02629 262543008526 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262543008527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543008528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543008529 ABC transporter; Region: ABC_tran_2; pfam12848 262543008530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543008531 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 262543008532 Predicted membrane protein [Function unknown]; Region: COG2259 262543008533 Predicted transcriptional regulators [Transcription]; Region: COG1733 262543008534 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 262543008535 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262543008536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543008537 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543008538 Probable transposase; Region: OrfB_IS605; pfam01385 262543008539 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543008540 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262543008541 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543008542 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 262543008543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543008544 motif II; other site 262543008545 UGMP family protein; Validated; Region: PRK09604 262543008546 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 262543008547 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 262543008548 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 262543008549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543008550 Coenzyme A binding pocket [chemical binding]; other site 262543008551 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 262543008552 Glycoprotease family; Region: Peptidase_M22; pfam00814 262543008553 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 262543008554 hypothetical protein; Provisional; Region: PRK04351 262543008555 SprT homologues; Region: SprT; cl01182 262543008556 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 262543008557 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 262543008558 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 262543008559 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 262543008560 RNA binding site [nucleotide binding]; other site 262543008561 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 262543008562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262543008563 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262543008564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262543008565 DNA binding residues [nucleotide binding] 262543008566 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 262543008567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008568 ATP binding site [chemical binding]; other site 262543008569 Mg2+ binding site [ion binding]; other site 262543008570 G-X-G motif; other site 262543008571 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262543008572 anti sigma factor interaction site; other site 262543008573 regulatory phosphorylation site [posttranslational modification]; other site 262543008574 PemK-like protein; Region: PemK; pfam02452 262543008575 alanine racemase; Reviewed; Region: alr; PRK00053 262543008576 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 262543008577 active site 262543008578 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262543008579 dimer interface [polypeptide binding]; other site 262543008580 substrate binding site [chemical binding]; other site 262543008581 catalytic residues [active] 262543008582 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 262543008583 Rhomboid family; Region: Rhomboid; pfam01694 262543008584 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 262543008585 aromatic arch; other site 262543008586 DCoH dimer interaction site [polypeptide binding]; other site 262543008587 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 262543008588 DCoH tetramer interaction site [polypeptide binding]; other site 262543008589 substrate binding site [chemical binding]; other site 262543008590 Isochorismatase family; Region: Isochorismatase; pfam00857 262543008591 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262543008592 catalytic triad [active] 262543008593 conserved cis-peptide bond; other site 262543008594 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 262543008595 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 262543008596 active site 262543008597 YwpF-like protein; Region: YwpF; pfam14183 262543008598 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262543008599 catalytic core [active] 262543008600 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262543008601 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262543008602 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 262543008603 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 262543008604 intersubunit interface [polypeptide binding]; other site 262543008605 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 262543008606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543008607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543008608 active site 262543008609 catalytic tetrad [active] 262543008610 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 262543008611 amino acid carrier protein; Region: agcS; TIGR00835 262543008612 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 262543008613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543008614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543008615 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543008616 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 262543008617 active site residue [active] 262543008618 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 262543008619 CPxP motif; other site 262543008620 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 262543008621 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 262543008622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262543008623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543008624 NAD(P) binding site [chemical binding]; other site 262543008625 active site 262543008626 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 262543008627 Sulfatase; Region: Sulfatase; cl17466 262543008628 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 262543008629 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 262543008630 Ligand binding site; other site 262543008631 Putative Catalytic site; other site 262543008632 DXD motif; other site 262543008633 Iron permease FTR1 family; Region: FTR1; cl00475 262543008634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 262543008635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262543008636 Coenzyme A binding pocket [chemical binding]; other site 262543008637 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262543008638 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543008639 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 262543008640 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 262543008641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543008642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543008643 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543008644 oxidoreductase; Provisional; Region: PRK07985 262543008645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543008646 NAD(P) binding site [chemical binding]; other site 262543008647 active site 262543008648 maltose O-acetyltransferase; Provisional; Region: PRK10092 262543008649 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 262543008650 active site 262543008651 substrate binding site [chemical binding]; other site 262543008652 trimer interface [polypeptide binding]; other site 262543008653 CoA binding site [chemical binding]; other site 262543008654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543008655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543008656 active site 262543008657 phosphorylation site [posttranslational modification] 262543008658 intermolecular recognition site; other site 262543008659 dimerization interface [polypeptide binding]; other site 262543008660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543008661 DNA binding site [nucleotide binding] 262543008662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543008663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543008664 dimerization interface [polypeptide binding]; other site 262543008665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008666 dimer interface [polypeptide binding]; other site 262543008667 phosphorylation site [posttranslational modification] 262543008668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008669 ATP binding site [chemical binding]; other site 262543008670 Mg2+ binding site [ion binding]; other site 262543008671 G-X-G motif; other site 262543008672 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 262543008673 Peptidase family M50; Region: Peptidase_M50; pfam02163 262543008674 active site 262543008675 putative substrate binding region [chemical binding]; other site 262543008676 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 262543008677 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 262543008678 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 262543008679 active site 262543008680 catalytic site [active] 262543008681 substrate binding site [chemical binding]; other site 262543008682 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 262543008683 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 262543008684 putative active site [active] 262543008685 putative FMN binding site [chemical binding]; other site 262543008686 putative substrate binding site [chemical binding]; other site 262543008687 putative catalytic residue [active] 262543008688 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 262543008689 Protein export membrane protein; Region: SecD_SecF; cl14618 262543008690 YycC-like protein; Region: YycC; pfam14174 262543008691 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 262543008692 active site 262543008693 pullulanase, type I; Region: pulA_typeI; TIGR02104 262543008694 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 262543008695 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 262543008696 Ca binding site [ion binding]; other site 262543008697 active site 262543008698 catalytic site [active] 262543008699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 262543008700 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 262543008701 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 262543008702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543008703 NAD(P) binding site [chemical binding]; other site 262543008704 active site 262543008705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262543008706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262543008707 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 262543008708 putative dimerization interface [polypeptide binding]; other site 262543008709 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 262543008710 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 262543008711 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 262543008712 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 262543008713 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 262543008714 active site 262543008715 HIGH motif; other site 262543008716 KMSK motif region; other site 262543008717 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 262543008718 tRNA binding surface [nucleotide binding]; other site 262543008719 anticodon binding site; other site 262543008720 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262543008721 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262543008722 metal binding site [ion binding]; metal-binding site 262543008723 active site 262543008724 I-site; other site 262543008725 Putative esterase; Region: Esterase; pfam00756 262543008726 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 262543008727 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 262543008728 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 262543008729 active site residue [active] 262543008730 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 262543008731 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262543008732 Protein of unknown function, DUF485; Region: DUF485; pfam04341 262543008733 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 262543008734 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 262543008735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 262543008736 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 262543008737 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 262543008738 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 262543008739 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 262543008740 hexamer interface [polypeptide binding]; other site 262543008741 ligand binding site [chemical binding]; other site 262543008742 putative active site [active] 262543008743 NAD(P) binding site [chemical binding]; other site 262543008744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 262543008745 binding surface 262543008746 Tetratricopeptide repeat; Region: TPR_16; pfam13432 262543008747 TPR motif; other site 262543008748 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 262543008749 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 262543008750 Restriction endonuclease; Region: Mrr_cat; pfam04471 262543008751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543008752 PAS domain; Region: PAS_9; pfam13426 262543008753 putative active site [active] 262543008754 heme pocket [chemical binding]; other site 262543008755 PAS domain S-box; Region: sensory_box; TIGR00229 262543008756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262543008757 putative active site [active] 262543008758 heme pocket [chemical binding]; other site 262543008759 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 262543008760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008761 dimer interface [polypeptide binding]; other site 262543008762 phosphorylation site [posttranslational modification] 262543008763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008764 ATP binding site [chemical binding]; other site 262543008765 Mg2+ binding site [ion binding]; other site 262543008766 G-X-G motif; other site 262543008767 thioester reductase domain; Region: Thioester-redct; TIGR01746 262543008768 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 262543008769 putative NAD(P) binding site [chemical binding]; other site 262543008770 active site 262543008771 putative substrate binding site [chemical binding]; other site 262543008772 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262543008773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262543008774 NAD(P) binding site [chemical binding]; other site 262543008775 active site 262543008776 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 262543008777 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 262543008778 flagellar motor protein MotA; Validated; Region: PRK08124 262543008779 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 262543008780 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 262543008781 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 262543008782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 262543008783 ligand binding site [chemical binding]; other site 262543008784 Protein of unknown function (DUF420); Region: DUF420; pfam04238 262543008785 mercuric reductase; Validated; Region: PRK06370 262543008786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543008787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262543008788 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 262543008789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543008790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543008791 dimerization interface [polypeptide binding]; other site 262543008792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008793 dimer interface [polypeptide binding]; other site 262543008794 phosphorylation site [posttranslational modification] 262543008795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008796 ATP binding site [chemical binding]; other site 262543008797 Mg2+ binding site [ion binding]; other site 262543008798 G-X-G motif; other site 262543008799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543008800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543008801 active site 262543008802 phosphorylation site [posttranslational modification] 262543008803 intermolecular recognition site; other site 262543008804 dimerization interface [polypeptide binding]; other site 262543008805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543008806 DNA binding site [nucleotide binding] 262543008807 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262543008808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262543008809 motif II; other site 262543008810 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262543008811 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 262543008812 ligand binding site [chemical binding]; other site 262543008813 active site 262543008814 UGI interface [polypeptide binding]; other site 262543008815 catalytic site [active] 262543008816 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 262543008817 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 262543008818 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262543008819 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262543008820 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543008821 MarR family; Region: MarR; pfam01047 262543008822 MarR family; Region: MarR_2; cl17246 262543008823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262543008824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262543008825 DNA binding site [nucleotide binding] 262543008826 domain linker motif; other site 262543008827 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 262543008828 putative dimerization interface [polypeptide binding]; other site 262543008829 putative ligand binding site [chemical binding]; other site 262543008830 Bacterial SH3 domain; Region: SH3_3; pfam08239 262543008831 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262543008832 NlpC/P60 family; Region: NLPC_P60; pfam00877 262543008833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 262543008834 Protein export membrane protein; Region: SecD_SecF; cl14618 262543008835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262543008836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262543008837 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 262543008838 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 262543008839 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 262543008840 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 262543008841 FOG: CBS domain [General function prediction only]; Region: COG0517 262543008842 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 262543008843 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 262543008844 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 262543008845 dimer interface [polypeptide binding]; other site 262543008846 substrate binding site [chemical binding]; other site 262543008847 ATP binding site [chemical binding]; other site 262543008848 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 262543008849 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262543008850 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 262543008851 Ligand Binding Site [chemical binding]; other site 262543008852 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 262543008853 active site 262543008854 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 262543008855 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 262543008856 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 262543008857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262543008858 non-specific DNA binding site [nucleotide binding]; other site 262543008859 salt bridge; other site 262543008860 sequence-specific DNA binding site [nucleotide binding]; other site 262543008861 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543008862 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 262543008863 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543008864 active site turn [active] 262543008865 phosphorylation site [posttranslational modification] 262543008866 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 262543008867 putative catalytic site [active] 262543008868 putative metal binding site [ion binding]; other site 262543008869 putative phosphate binding site [ion binding]; other site 262543008870 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 262543008871 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262543008872 active site turn [active] 262543008873 phosphorylation site [posttranslational modification] 262543008874 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262543008875 CAT RNA binding domain; Region: CAT_RBD; smart01061 262543008876 PRD domain; Region: PRD; pfam00874 262543008877 PRD domain; Region: PRD; pfam00874 262543008878 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262543008879 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 262543008880 putative substrate binding site [chemical binding]; other site 262543008881 putative ATP binding site [chemical binding]; other site 262543008882 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262543008883 putative uracil/xanthine transporter; Provisional; Region: PRK11412 262543008884 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 262543008885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543008886 putative substrate translocation pore; other site 262543008887 POT family; Region: PTR2; cl17359 262543008888 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 262543008889 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262543008890 NAD binding site [chemical binding]; other site 262543008891 active site 262543008892 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 262543008893 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262543008894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543008895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543008896 ABC transporter; Region: ABC_tran_2; pfam12848 262543008897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543008898 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262543008899 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 262543008900 ApbE family; Region: ApbE; pfam02424 262543008901 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543008902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543008903 active site 262543008904 phosphorylation site [posttranslational modification] 262543008905 intermolecular recognition site; other site 262543008906 dimerization interface [polypeptide binding]; other site 262543008907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543008908 DNA binding site [nucleotide binding] 262543008909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262543008910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543008911 dimer interface [polypeptide binding]; other site 262543008912 phosphorylation site [posttranslational modification] 262543008913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543008914 ATP binding site [chemical binding]; other site 262543008915 Mg2+ binding site [ion binding]; other site 262543008916 G-X-G motif; other site 262543008917 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 262543008918 helicase 45; Provisional; Region: PTZ00424 262543008919 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262543008920 ATP binding site [chemical binding]; other site 262543008921 Mg++ binding site [ion binding]; other site 262543008922 motif III; other site 262543008923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543008924 nucleotide binding region [chemical binding]; other site 262543008925 ATP-binding site [chemical binding]; other site 262543008926 integral membrane protein; Region: integ_memb_HG; TIGR03954 262543008927 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 262543008928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543008929 Zn binding site [ion binding]; other site 262543008930 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 262543008931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262543008932 Zn binding site [ion binding]; other site 262543008933 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262543008934 DNA-binding site [nucleotide binding]; DNA binding site 262543008935 RNA-binding motif; other site 262543008936 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 262543008937 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 262543008938 HAMP domain; Region: HAMP; pfam00672 262543008939 dimerization interface [polypeptide binding]; other site 262543008940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262543008941 Zn2+ binding site [ion binding]; other site 262543008942 Mg2+ binding site [ion binding]; other site 262543008943 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 262543008944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 262543008945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 262543008946 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 262543008947 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 262543008948 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 262543008949 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 262543008950 active site 262543008951 Zn binding site [ion binding]; other site 262543008952 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 262543008953 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 262543008954 NADP binding site [chemical binding]; other site 262543008955 dimer interface [polypeptide binding]; other site 262543008956 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 262543008957 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 262543008958 Uncharacterized conserved protein [Function unknown]; Region: COG3342 262543008959 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 262543008960 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 262543008961 Predicted membrane protein [Function unknown]; Region: COG1288 262543008962 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 262543008963 Uncharacterized conserved protein [Function unknown]; Region: COG1359 262543008964 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 262543008965 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543008966 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543008967 active site 262543008968 catalytic tetrad [active] 262543008969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262543008970 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262543008971 active site 262543008972 catalytic tetrad [active] 262543008973 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 262543008974 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 262543008975 PLD-like domain; Region: PLDc_2; pfam13091 262543008976 putative homodimer interface [polypeptide binding]; other site 262543008977 putative active site [active] 262543008978 catalytic site [active] 262543008979 DEAD-like helicases superfamily; Region: DEXDc; smart00487 262543008980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262543008981 ATP binding site [chemical binding]; other site 262543008982 putative Mg++ binding site [ion binding]; other site 262543008983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543008984 nucleotide binding region [chemical binding]; other site 262543008985 ATP-binding site [chemical binding]; other site 262543008986 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 262543008987 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 262543008988 active site 262543008989 8-oxo-dGMP binding site [chemical binding]; other site 262543008990 nudix motif; other site 262543008991 metal binding site [ion binding]; metal-binding site 262543008992 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 262543008993 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 262543008994 putative RNA binding site [nucleotide binding]; other site 262543008995 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 262543008996 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262543008997 putative NAD(P) binding site [chemical binding]; other site 262543008998 peptidase T; Region: peptidase-T; TIGR01882 262543008999 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 262543009000 metal binding site [ion binding]; metal-binding site 262543009001 dimer interface [polypeptide binding]; other site 262543009002 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 262543009003 SPFH domain / Band 7 family; Region: Band_7; pfam01145 262543009004 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 262543009005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543009006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543009007 ABC transporter; Region: ABC_tran_2; pfam12848 262543009008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262543009009 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 262543009010 nudix motif; other site 262543009011 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262543009012 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 262543009013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262543009014 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 262543009015 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 262543009016 active site 262543009017 dimer interface [polypeptide binding]; other site 262543009018 non-prolyl cis peptide bond; other site 262543009019 insertion regions; other site 262543009020 Protein of unknown function (DUF975); Region: DUF975; cl10504 262543009021 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 262543009022 Protein of unknown function (DUF817); Region: DUF817; pfam05675 262543009023 Predicted membrane protein [Function unknown]; Region: COG2364 262543009024 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543009025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262543009026 putative DNA binding site [nucleotide binding]; other site 262543009027 putative Zn2+ binding site [ion binding]; other site 262543009028 MarR family; Region: MarR_2; cl17246 262543009029 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 262543009030 dimer interface [polypeptide binding]; other site 262543009031 FMN binding site [chemical binding]; other site 262543009032 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 262543009033 dimer interface [polypeptide binding]; other site 262543009034 FMN binding site [chemical binding]; other site 262543009035 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 262543009036 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262543009037 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 262543009038 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262543009039 ATP binding site [chemical binding]; other site 262543009040 Mg++ binding site [ion binding]; other site 262543009041 motif III; other site 262543009042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262543009043 nucleotide binding region [chemical binding]; other site 262543009044 ATP-binding site [chemical binding]; other site 262543009045 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 262543009046 RNA binding site [nucleotide binding]; other site 262543009047 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 262543009048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262543009049 FeS/SAM binding site; other site 262543009050 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262543009051 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262543009052 Walker A/P-loop; other site 262543009053 ATP binding site [chemical binding]; other site 262543009054 Q-loop/lid; other site 262543009055 ABC transporter signature motif; other site 262543009056 Walker B; other site 262543009057 D-loop; other site 262543009058 H-loop/switch region; other site 262543009059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543009060 S-adenosylmethionine binding site [chemical binding]; other site 262543009061 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315 262543009062 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 262543009063 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 262543009064 heat shock protein 90; Provisional; Region: PRK05218 262543009065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543009066 ATP binding site [chemical binding]; other site 262543009067 Mg2+ binding site [ion binding]; other site 262543009068 G-X-G motif; other site 262543009069 short chain dehydrogenase; Validated; Region: PRK08589 262543009070 classical (c) SDRs; Region: SDR_c; cd05233 262543009071 NAD(P) binding site [chemical binding]; other site 262543009072 active site 262543009073 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 262543009074 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 262543009075 metal binding site [ion binding]; metal-binding site 262543009076 dimer interface [polypeptide binding]; other site 262543009077 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 262543009078 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 262543009079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262543009080 putative substrate translocation pore; other site 262543009081 FOG: CBS domain [General function prediction only]; Region: COG0517 262543009082 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 262543009083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262543009084 MarR family; Region: MarR_2; pfam12802 262543009085 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 262543009086 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 262543009087 S-methylmethionine transporter; Provisional; Region: PRK11387 262543009088 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 262543009089 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 262543009090 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 262543009091 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 262543009092 Transcriptional regulators [Transcription]; Region: GntR; COG1802 262543009093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262543009094 DNA-binding site [nucleotide binding]; DNA binding site 262543009095 FCD domain; Region: FCD; pfam07729 262543009096 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 262543009097 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 262543009098 N- and C-terminal domain interface [polypeptide binding]; other site 262543009099 active site 262543009100 catalytic site [active] 262543009101 metal binding site [ion binding]; metal-binding site 262543009102 carbohydrate binding site [chemical binding]; other site 262543009103 ATP binding site [chemical binding]; other site 262543009104 fructuronate transporter; Provisional; Region: PRK10034; cl15264 262543009105 gluconate transporter; Region: gntP; TIGR00791 262543009106 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262543009107 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 262543009108 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 262543009109 peroxiredoxin; Region: AhpC; TIGR03137 262543009110 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 262543009111 dimer interface [polypeptide binding]; other site 262543009112 decamer (pentamer of dimers) interface [polypeptide binding]; other site 262543009113 catalytic triad [active] 262543009114 peroxidatic and resolving cysteines [active] 262543009115 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 262543009116 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 262543009117 catalytic residue [active] 262543009118 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 262543009119 catalytic residues [active] 262543009120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262543009121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262543009122 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 262543009123 malate:quinone oxidoreductase; Validated; Region: PRK05257 262543009124 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 262543009125 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 262543009126 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262543009127 catalytic core [active] 262543009128 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 262543009129 nudix motif; other site 262543009130 Tubby C 2; Region: Tub_2; cl02043 262543009131 Tubby C 2; Region: Tub_2; cl02043 262543009132 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 262543009133 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 262543009134 FMN binding site [chemical binding]; other site 262543009135 active site 262543009136 catalytic residues [active] 262543009137 substrate binding site [chemical binding]; other site 262543009138 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 262543009139 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 262543009140 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 262543009141 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 262543009142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262543009143 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262543009144 substrate binding pocket [chemical binding]; other site 262543009145 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 262543009146 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 262543009147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 262543009148 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 262543009149 Probable transposase; Region: OrfB_IS605; pfam01385 262543009150 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 262543009151 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 262543009152 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 262543009153 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262543009154 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262543009155 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 262543009156 protein binding site [polypeptide binding]; other site 262543009157 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 262543009158 YycH protein; Region: YycI; pfam09648 262543009159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 262543009160 YycH protein; Region: YycH; pfam07435 262543009161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 262543009162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262543009163 dimerization interface [polypeptide binding]; other site 262543009164 PAS domain; Region: PAS; smart00091 262543009165 putative active site [active] 262543009166 heme pocket [chemical binding]; other site 262543009167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262543009168 dimer interface [polypeptide binding]; other site 262543009169 phosphorylation site [posttranslational modification] 262543009170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262543009171 ATP binding site [chemical binding]; other site 262543009172 Mg2+ binding site [ion binding]; other site 262543009173 G-X-G motif; other site 262543009174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262543009175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262543009176 active site 262543009177 phosphorylation site [posttranslational modification] 262543009178 intermolecular recognition site; other site 262543009179 dimerization interface [polypeptide binding]; other site 262543009180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262543009181 DNA binding site [nucleotide binding] 262543009182 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 262543009183 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 262543009184 GDP-binding site [chemical binding]; other site 262543009185 ACT binding site; other site 262543009186 IMP binding site; other site 262543009187 replicative DNA helicase; Provisional; Region: PRK05748 262543009188 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 262543009189 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 262543009190 Walker A motif; other site 262543009191 ATP binding site [chemical binding]; other site 262543009192 Walker B motif; other site 262543009193 DNA binding loops [nucleotide binding] 262543009194 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 262543009195 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 262543009196 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 262543009197 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 262543009198 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 262543009199 DHH family; Region: DHH; pfam01368 262543009200 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 262543009201 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 262543009202 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 262543009203 dimer interface [polypeptide binding]; other site 262543009204 ssDNA binding site [nucleotide binding]; other site 262543009205 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262543009206 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 262543009207 GTP-binding protein YchF; Reviewed; Region: PRK09601 262543009208 YchF GTPase; Region: YchF; cd01900 262543009209 G1 box; other site 262543009210 GTP/Mg2+ binding site [chemical binding]; other site 262543009211 Switch I region; other site 262543009212 G2 box; other site 262543009213 Switch II region; other site 262543009214 G3 box; other site 262543009215 G4 box; other site 262543009216 G5 box; other site 262543009217 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 262543009218 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 262543009219 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 262543009220 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262543009221 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 262543009222 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 262543009223 ParB-like nuclease domain; Region: ParB; smart00470 262543009224 KorB domain; Region: KorB; pfam08535 262543009225 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 262543009226 ParB-like nuclease domain; Region: ParB; smart00470 262543009227 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 262543009228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262543009229 S-adenosylmethionine binding site [chemical binding]; other site 262543009230 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 262543009231 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 262543009232 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 262543009233 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 262543009234 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 262543009235 trmE is a tRNA modification GTPase; Region: trmE; cd04164 262543009236 G1 box; other site 262543009237 GTP/Mg2+ binding site [chemical binding]; other site 262543009238 Switch I region; other site 262543009239 G2 box; other site 262543009240 Switch II region; other site 262543009241 G3 box; other site 262543009242 G4 box; other site 262543009243 G5 box; other site 262543009244 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 262543009245 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 262543009246 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 262543009247 ribonuclease P; Reviewed; Region: rnpA; PRK00499 262543009248 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399