-- dump date   	20140619_092426
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
718252000001	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252000002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252000003	P-loop; other site
718252000004	Magnesium ion binding site [ion binding]; other site
718252000005	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252000006	Magnesium ion binding site [ion binding]; other site
718252000007	Protein of unknown function (DUF3848); Region: DUF3848; pfam12959
718252000008	Protein of unknown function (DUF3848); Region: DUF3848; pfam12959
718252000009	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
718252000010	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
718252000011	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
718252000012	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252000013	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252000014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252000015	non-specific DNA binding site [nucleotide binding]; other site
718252000016	salt bridge; other site
718252000017	sequence-specific DNA binding site [nucleotide binding]; other site
718252000018	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
718252000019	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
718252000020	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
718252000021	Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691
718252000022	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
718252000023	Predicted transcriptional regulator [Transcription]; Region: COG2378
718252000024	WYL domain; Region: WYL; pfam13280
718252000025	Domain of unknown function (DUF955); Region: DUF955; pfam06114
718252000026	PemK-like protein; Region: PemK; pfam02452
718252000027	Helix-turn-helix domain; Region: HTH_17; cl17695
718252000028	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252000029	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718252000030	Int/Topo IB signature motif; other site
718252000031	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
718252000032	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
718252000033	putative interdomain interaction site [polypeptide binding]; other site
718252000034	DNA topoisomerase III; Provisional; Region: PRK07726
718252000035	active site
718252000036	putative metal-binding site [ion binding]; other site
718252000037	putative nucleotide binding site [chemical binding]; other site
718252000038	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
718252000039	domain I; other site
718252000040	DNA binding groove [nucleotide binding]
718252000041	phosphate binding site [ion binding]; other site
718252000042	domain II; other site
718252000043	domain III; other site
718252000044	nucleotide binding site [chemical binding]; other site
718252000045	catalytic site [active]
718252000046	domain IV; other site
718252000047	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252000048	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
718252000049	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252000050	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252000051	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
718252000052	Phage tail tube protein FII; Region: Phage_tube; cl01390
718252000053	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
718252000054	SAP domain; Region: SAP; cl02640
718252000055	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
718252000056	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
718252000057	oligomer interface [polypeptide binding]; other site
718252000058	active site residues [active]
718252000059	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
718252000060	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
718252000061	ParB-like nuclease domain; Region: ParB; smart00470
718252000062	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
718252000063	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
718252000064	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
718252000065	Ligand Binding Site [chemical binding]; other site
718252000066	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
718252000067	ParB-like nuclease domain; Region: ParB; smart00470
718252000068	The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022
718252000069	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
718252000070	ParB-like nuclease domain; Region: ParB; smart00470
718252000071	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
718252000072	EAP30/Vps36 family; Region: EAP30; pfam04157
718252000073	3D domain; Region: 3D; cl01439
718252000074	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
718252000075	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
718252000076	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718252000077	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718252000078	dimer interface [polypeptide binding]; other site
718252000079	ssDNA binding site [nucleotide binding]; other site
718252000080	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718252000081	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
718252000082	AAA domain; Region: AAA_24; pfam13479
718252000083	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
718252000084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
718252000085	non-specific DNA binding site [nucleotide binding]; other site
718252000086	salt bridge; other site
718252000087	sequence-specific DNA binding site [nucleotide binding]; other site
718252000088	Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620
718252000089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252000090	non-specific DNA binding site [nucleotide binding]; other site
718252000091	salt bridge; other site
718252000092	sequence-specific DNA binding site [nucleotide binding]; other site
718252000093	Short C-terminal domain; Region: SHOCT; pfam09851
718252000094	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252000095	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252000096	catalytic residues [active]
718252000097	catalytic nucleophile [active]
718252000098	Recombinase; Region: Recombinase; pfam07508
718252000099	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252000100	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718252000101	S-formylglutathione hydrolase; Region: PLN02442
718252000102	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
718252000103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252000104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252000105	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252000106	dimerization interface [polypeptide binding]; other site
718252000107	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
718252000108	DNA binding site [nucleotide binding]
718252000109	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
718252000110	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
718252000111	NAD binding site [chemical binding]; other site
718252000112	ligand binding site [chemical binding]; other site
718252000113	catalytic site [active]
718252000114	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
718252000115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252000116	active site
718252000117	phosphorylation site [posttranslational modification]
718252000118	intermolecular recognition site; other site
718252000119	dimerization interface [polypeptide binding]; other site
718252000120	LytTr DNA-binding domain; Region: LytTR; smart00850
718252000121	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718252000122	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718252000123	metal binding site [ion binding]; metal-binding site
718252000124	active site
718252000125	I-site; other site
718252000126	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
718252000127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252000128	active site
718252000129	phosphorylation site [posttranslational modification]
718252000130	intermolecular recognition site; other site
718252000131	dimerization interface [polypeptide binding]; other site
718252000132	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252000133	Zn2+ binding site [ion binding]; other site
718252000134	Mg2+ binding site [ion binding]; other site
718252000135	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
718252000136	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
718252000137	dimer interface [polypeptide binding]; other site
718252000138	active site
718252000139	metal binding site [ion binding]; metal-binding site
718252000140	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
718252000141	ATP synthase subunit C; Region: ATP-synt_C; cl00466
718252000142	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
718252000143	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
718252000144	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
718252000145	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718252000146	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
718252000147	beta subunit interaction interface [polypeptide binding]; other site
718252000148	Walker A motif; other site
718252000149	ATP binding site [chemical binding]; other site
718252000150	Walker B motif; other site
718252000151	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718252000152	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
718252000153	core domain interface [polypeptide binding]; other site
718252000154	delta subunit interface [polypeptide binding]; other site
718252000155	epsilon subunit interface [polypeptide binding]; other site
718252000156	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
718252000157	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718252000158	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
718252000159	alpha subunit interaction interface [polypeptide binding]; other site
718252000160	Walker A motif; other site
718252000161	ATP binding site [chemical binding]; other site
718252000162	Walker B motif; other site
718252000163	inhibitor binding site; inhibition site
718252000164	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718252000165	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
718252000166	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
718252000167	gamma subunit interface [polypeptide binding]; other site
718252000168	epsilon subunit interface [polypeptide binding]; other site
718252000169	LBP interface [polypeptide binding]; other site
718252000170	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
718252000171	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
718252000172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
718252000173	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
718252000174	ApbE family; Region: ApbE; pfam02424
718252000175	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
718252000176	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
718252000177	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
718252000178	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
718252000179	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
718252000180	putative deacylase active site [active]
718252000181	AIR carboxylase; Region: AIRC; pfam00731
718252000182	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
718252000183	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
718252000184	active site
718252000185	tetramer interface [polypeptide binding]; other site
718252000186	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252000187	active site
718252000188	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
718252000189	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
718252000190	dimerization interface [polypeptide binding]; other site
718252000191	putative ATP binding site [chemical binding]; other site
718252000192	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
718252000193	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
718252000194	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
718252000195	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
718252000196	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
718252000197	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
718252000198	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
718252000199	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
718252000200	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
718252000201	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
718252000202	dimerization interface [polypeptide binding]; other site
718252000203	ATP binding site [chemical binding]; other site
718252000204	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
718252000205	dimerization interface [polypeptide binding]; other site
718252000206	ATP binding site [chemical binding]; other site
718252000207	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
718252000208	putative active site [active]
718252000209	catalytic triad [active]
718252000210	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
718252000211	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
718252000212	tetramer interface [polypeptide binding]; other site
718252000213	active site
718252000214	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
718252000215	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252000216	RNA binding surface [nucleotide binding]; other site
718252000217	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
718252000218	active site
718252000219	uracil binding [chemical binding]; other site
718252000220	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
718252000221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252000222	Walker A/P-loop; other site
718252000223	ATP binding site [chemical binding]; other site
718252000224	Q-loop/lid; other site
718252000225	ABC transporter signature motif; other site
718252000226	Walker B; other site
718252000227	D-loop; other site
718252000228	H-loop/switch region; other site
718252000229	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
718252000230	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
718252000231	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
718252000232	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
718252000233	protein binding site [polypeptide binding]; other site
718252000234	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
718252000235	Catalytic dyad [active]
718252000236	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
718252000237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252000238	S-adenosylmethionine binding site [chemical binding]; other site
718252000239	PBP superfamily domain; Region: PBP_like_2; cl17296
718252000240	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252000241	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718252000242	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
718252000243	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
718252000244	putative sugar binding sites [chemical binding]; other site
718252000245	Q-X-W motif; other site
718252000246	CTP synthetase; Validated; Region: pyrG; PRK05380
718252000247	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
718252000248	Catalytic site [active]
718252000249	active site
718252000250	UTP binding site [chemical binding]; other site
718252000251	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
718252000252	active site
718252000253	putative oxyanion hole; other site
718252000254	catalytic triad [active]
718252000255	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
718252000256	ANTAR domain; Region: ANTAR; pfam03861
718252000257	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
718252000258	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
718252000259	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
718252000260	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
718252000261	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
718252000262	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
718252000263	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
718252000264	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
718252000265	putative RNA binding site [nucleotide binding]; other site
718252000266	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718252000267	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
718252000268	putative active site [active]
718252000269	putative metal binding residues [ion binding]; other site
718252000270	signature motif; other site
718252000271	putative dimer interface [polypeptide binding]; other site
718252000272	putative phosphate binding site [ion binding]; other site
718252000273	Predicted membrane protein [Function unknown]; Region: COG1511
718252000274	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
718252000275	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
718252000276	active site
718252000277	nucleophile elbow; other site
718252000278	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252000279	active site
718252000280	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
718252000281	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718252000282	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718252000283	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
718252000284	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
718252000285	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
718252000286	putative active site [active]
718252000287	cell division protein FtsZ; Region: ftsZ; TIGR00065
718252000288	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
718252000289	nucleotide binding site [chemical binding]; other site
718252000290	SulA interaction site; other site
718252000291	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
718252000292	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
718252000293	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
718252000294	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718252000295	active site
718252000296	metal binding site [ion binding]; metal-binding site
718252000297	DNA binding site [nucleotide binding]
718252000298	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
718252000299	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
718252000300	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252000301	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252000302	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
718252000303	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
718252000304	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
718252000305	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
718252000306	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
718252000307	AsnC family; Region: AsnC_trans_reg; pfam01037
718252000308	hypothetical protein; Validated; Region: PRK07682
718252000309	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718252000310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252000311	homodimer interface [polypeptide binding]; other site
718252000312	catalytic residue [active]
718252000313	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
718252000314	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718252000315	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
718252000316	active site
718252000317	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
718252000318	Family description; Region: UvrD_C_2; pfam13538
718252000319	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
718252000320	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
718252000321	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
718252000322	23S rRNA binding site [nucleotide binding]; other site
718252000323	L21 binding site [polypeptide binding]; other site
718252000324	L13 binding site [polypeptide binding]; other site
718252000325	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
718252000326	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
718252000327	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718252000328	DNA topoisomerase I; Validated; Region: PRK05582
718252000329	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
718252000330	active site
718252000331	interdomain interaction site; other site
718252000332	putative metal-binding site [ion binding]; other site
718252000333	nucleotide binding site [chemical binding]; other site
718252000334	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
718252000335	domain I; other site
718252000336	DNA binding groove [nucleotide binding]
718252000337	phosphate binding site [ion binding]; other site
718252000338	domain II; other site
718252000339	domain III; other site
718252000340	nucleotide binding site [chemical binding]; other site
718252000341	catalytic site [active]
718252000342	domain IV; other site
718252000343	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718252000344	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718252000345	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
718252000346	Glucose inhibited division protein A; Region: GIDA; pfam01134
718252000347	ribonuclease III; Reviewed; Region: rnc; PRK00102
718252000348	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
718252000349	dimerization interface [polypeptide binding]; other site
718252000350	active site
718252000351	metal binding site [ion binding]; metal-binding site
718252000352	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
718252000353	dsRNA binding site [nucleotide binding]; other site
718252000354	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
718252000355	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
718252000356	Walker A/P-loop; other site
718252000357	ATP binding site [chemical binding]; other site
718252000358	Q-loop/lid; other site
718252000359	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
718252000360	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
718252000361	ABC transporter signature motif; other site
718252000362	Walker B; other site
718252000363	D-loop; other site
718252000364	H-loop/switch region; other site
718252000365	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
718252000366	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
718252000367	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
718252000368	P loop; other site
718252000369	GTP binding site [chemical binding]; other site
718252000370	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
718252000371	active site
718252000372	dimerization interface [polypeptide binding]; other site
718252000373	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
718252000374	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
718252000375	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
718252000376	active site
718252000377	(T/H)XGH motif; other site
718252000378	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252000379	Zn2+ binding site [ion binding]; other site
718252000380	Mg2+ binding site [ion binding]; other site
718252000381	Oligomerisation domain; Region: Oligomerisation; pfam02410
718252000382	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
718252000383	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
718252000384	HIGH motif; other site
718252000385	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
718252000386	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718252000387	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718252000388	active site
718252000389	KMSKS motif; other site
718252000390	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
718252000391	tRNA binding surface [nucleotide binding]; other site
718252000392	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
718252000393	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
718252000394	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252000395	active site
718252000396	motif I; other site
718252000397	motif II; other site
718252000398	elongation factor P; Validated; Region: PRK00529
718252000399	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
718252000400	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
718252000401	RNA binding site [nucleotide binding]; other site
718252000402	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
718252000403	RNA binding site [nucleotide binding]; other site
718252000404	chaperone protein DnaJ; Provisional; Region: PRK14291
718252000405	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
718252000406	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
718252000407	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718252000408	active site
718252000409	HIGH motif; other site
718252000410	nucleotide binding site [chemical binding]; other site
718252000411	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
718252000412	KMSK motif region; other site
718252000413	tRNA binding surface [nucleotide binding]; other site
718252000414	DALR anticodon binding domain; Region: DALR_1; smart00836
718252000415	anticodon binding site; other site
718252000416	glutamate racemase; Provisional; Region: PRK00865
718252000417	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
718252000418	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
718252000419	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
718252000420	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
718252000421	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
718252000422	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
718252000423	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
718252000424	putative homodimer interface [polypeptide binding]; other site
718252000425	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
718252000426	heterodimer interface [polypeptide binding]; other site
718252000427	homodimer interface [polypeptide binding]; other site
718252000428	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
718252000429	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
718252000430	23S rRNA interface [nucleotide binding]; other site
718252000431	L7/L12 interface [polypeptide binding]; other site
718252000432	putative thiostrepton binding site; other site
718252000433	L25 interface [polypeptide binding]; other site
718252000434	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
718252000435	mRNA/rRNA interface [nucleotide binding]; other site
718252000436	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
718252000437	23S rRNA interface [nucleotide binding]; other site
718252000438	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
718252000439	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
718252000440	L11 interface [polypeptide binding]; other site
718252000441	putative EF-Tu interaction site [polypeptide binding]; other site
718252000442	putative EF-G interaction site [polypeptide binding]; other site
718252000443	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
718252000444	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
718252000445	Potassium binding sites [ion binding]; other site
718252000446	Cesium cation binding sites [ion binding]; other site
718252000447	Stage II sporulation protein; Region: SpoIID; pfam08486
718252000448	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
718252000449	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
718252000450	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
718252000451	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
718252000452	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
718252000453	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718252000454	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
718252000455	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
718252000456	Phosphoglycerate kinase; Region: PGK; pfam00162
718252000457	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
718252000458	substrate binding site [chemical binding]; other site
718252000459	hinge regions; other site
718252000460	ADP binding site [chemical binding]; other site
718252000461	catalytic site [active]
718252000462	triosephosphate isomerase; Provisional; Region: PRK14567
718252000463	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
718252000464	substrate binding site [chemical binding]; other site
718252000465	dimer interface [polypeptide binding]; other site
718252000466	catalytic triad [active]
718252000467	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
718252000468	phosphoglyceromutase; Provisional; Region: PRK05434
718252000469	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
718252000470	4Fe-4S binding domain; Region: Fer4; pfam00037
718252000471	4Fe-4S binding domain; Region: Fer4; pfam00037
718252000472	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
718252000473	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
718252000474	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718252000475	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252000476	FeS/SAM binding site; other site
718252000477	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718252000478	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718252000479	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
718252000480	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
718252000481	active site
718252000482	dimer interface [polypeptide binding]; other site
718252000483	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
718252000484	dimer interface [polypeptide binding]; other site
718252000485	active site
718252000486	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718252000487	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
718252000488	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
718252000489	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
718252000490	Protein of unknown function (DUF512); Region: DUF512; pfam04459
718252000491	GTP-binding protein Der; Reviewed; Region: PRK00093
718252000492	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
718252000493	G1 box; other site
718252000494	GTP/Mg2+ binding site [chemical binding]; other site
718252000495	Switch I region; other site
718252000496	G2 box; other site
718252000497	Switch II region; other site
718252000498	G3 box; other site
718252000499	G4 box; other site
718252000500	G5 box; other site
718252000501	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
718252000502	G1 box; other site
718252000503	GTP/Mg2+ binding site [chemical binding]; other site
718252000504	Switch I region; other site
718252000505	G2 box; other site
718252000506	G3 box; other site
718252000507	Switch II region; other site
718252000508	G4 box; other site
718252000509	G5 box; other site
718252000510	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
718252000511	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
718252000512	homotrimer interaction site [polypeptide binding]; other site
718252000513	putative active site [active]
718252000514	Helicase associated domain; Region: HA; pfam03457
718252000515	Helicase associated domain; Region: HA; pfam03457
718252000516	Helicase associated domain; Region: HA; pfam03457
718252000517	Helicase associated domain; Region: HA; pfam03457
718252000518	Helicase associated domain; Region: HA; pfam03457
718252000519	Helicase associated domain; Region: HA; pfam03457
718252000520	Helicase associated domain; Region: HA; pfam03457
718252000521	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
718252000522	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
718252000523	active site
718252000524	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
718252000525	active site
718252000526	N-terminal domain interface [polypeptide binding]; other site
718252000527	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
718252000528	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
718252000529	intersubunit interface [polypeptide binding]; other site
718252000530	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
718252000531	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718252000532	ABC-ATPase subunit  interface; other site
718252000533	dimer interface [polypeptide binding]; other site
718252000534	putative PBP binding regions; other site
718252000535	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718252000536	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718252000537	Walker A/P-loop; other site
718252000538	ATP binding site [chemical binding]; other site
718252000539	Q-loop/lid; other site
718252000540	ABC transporter signature motif; other site
718252000541	Walker B; other site
718252000542	D-loop; other site
718252000543	H-loop/switch region; other site
718252000544	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
718252000545	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
718252000546	active site
718252000547	SAM binding site [chemical binding]; other site
718252000548	homodimer interface [polypeptide binding]; other site
718252000549	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
718252000550	active site
718252000551	SAM binding site [chemical binding]; other site
718252000552	homodimer interface [polypeptide binding]; other site
718252000553	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
718252000554	active site
718252000555	SAM binding site [chemical binding]; other site
718252000556	homodimer interface [polypeptide binding]; other site
718252000557	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
718252000558	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
718252000559	active site
718252000560	putative homodimer interface [polypeptide binding]; other site
718252000561	SAM binding site [chemical binding]; other site
718252000562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
718252000563	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
718252000564	S-adenosylmethionine binding site [chemical binding]; other site
718252000565	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
718252000566	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718252000567	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
718252000568	catalytic triad [active]
718252000569	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
718252000570	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
718252000571	active site pocket [active]
718252000572	putative dimer interface [polypeptide binding]; other site
718252000573	putative cataytic base [active]
718252000574	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
718252000575	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
718252000576	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718252000577	catalytic core [active]
718252000578	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
718252000579	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
718252000580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718252000581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252000582	homodimer interface [polypeptide binding]; other site
718252000583	catalytic residue [active]
718252000584	cobyric acid synthase; Provisional; Region: PRK00784
718252000585	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718252000586	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
718252000587	catalytic triad [active]
718252000588	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
718252000589	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252000590	Coenzyme A binding pocket [chemical binding]; other site
718252000591	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
718252000592	metal ion-dependent adhesion site (MIDAS); other site
718252000593	MoxR-like ATPases [General function prediction only]; Region: COG0714
718252000594	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
718252000595	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718252000596	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
718252000597	Helix-turn-helix domain; Region: HTH_16; pfam12645
718252000598	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
718252000599	active site
718252000600	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
718252000601	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
718252000602	dimer interface [polypeptide binding]; other site
718252000603	active site
718252000604	metal binding site [ion binding]; metal-binding site
718252000605	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
718252000606	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718252000607	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718252000608	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718252000609	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252000610	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252000611	metal-binding site [ion binding]
718252000612	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
718252000613	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
718252000614	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
718252000615	putative active site [active]
718252000616	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
718252000617	DEAD_2; Region: DEAD_2; pfam06733
718252000618	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
718252000619	hypothetical protein; Provisional; Region: PRK06851
718252000620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
718252000621	Walker A motif; other site
718252000622	ATP binding site [chemical binding]; other site
718252000623	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
718252000624	Fe-S cluster binding site [ion binding]; other site
718252000625	active site
718252000626	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
718252000627	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
718252000628	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252000629	non-specific DNA binding site [nucleotide binding]; other site
718252000630	salt bridge; other site
718252000631	sequence-specific DNA binding site [nucleotide binding]; other site
718252000632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718252000633	Transposase; Region: HTH_Tnp_1; cl17663
718252000634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
718252000635	HTH-like domain; Region: HTH_21; pfam13276
718252000636	Integrase core domain; Region: rve; pfam00665
718252000637	Integrase core domain; Region: rve_3; pfam13683
718252000638	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
718252000639	SmpB-tmRNA interface; other site
718252000640	recombination protein RecR; Reviewed; Region: recR; PRK00076
718252000641	RecR protein; Region: RecR; pfam02132
718252000642	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
718252000643	putative active site [active]
718252000644	putative metal-binding site [ion binding]; other site
718252000645	tetramer interface [polypeptide binding]; other site
718252000646	hypothetical protein; Validated; Region: PRK00153
718252000647	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
718252000648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252000649	Walker A motif; other site
718252000650	ATP binding site [chemical binding]; other site
718252000651	Walker B motif; other site
718252000652	arginine finger; other site
718252000653	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
718252000654	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
718252000655	catalytic triad [active]
718252000656	active site nucleophile [active]
718252000657	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252000658	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252000659	catalytic residues [active]
718252000660	catalytic nucleophile [active]
718252000661	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
718252000662	DNA methylase; Region: N6_N4_Mtase; pfam01555
718252000663	DNA methylase; Region: N6_N4_Mtase; cl17433
718252000664	helicase superfamily c-terminal domain; Region: HELICc; smart00490
718252000665	ATP-binding site [chemical binding]; other site
718252000666	ParB-like nuclease domain; Region: ParBc; pfam02195
718252000667	Antirestriction protein (ArdA); Region: ArdA; pfam07275
718252000668	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252000669	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
718252000670	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252000671	Walker A motif; other site
718252000672	ATP binding site [chemical binding]; other site
718252000673	Walker B motif; other site
718252000674	Maff2 family; Region: Maff2; pfam12750
718252000675	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
718252000676	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
718252000677	DNA methylase; Region: N6_N4_Mtase; cl17433
718252000678	DNA methylase; Region: N6_N4_Mtase; pfam01555
718252000679	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
718252000680	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252000681	active site
718252000682	DNA binding site [nucleotide binding]
718252000683	Int/Topo IB signature motif; other site
718252000684	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252000685	active site
718252000686	DNA binding site [nucleotide binding]
718252000687	Int/Topo IB signature motif; other site
718252000688	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252000689	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252000690	Type II intron maturase; Region: Intron_maturas2; pfam01348
718252000691	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
718252000692	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252000693	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
718252000694	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
718252000695	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
718252000696	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252000697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
718252000698	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718252000699	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252000700	Presynaptic Site I dimer interface [polypeptide binding]; other site
718252000701	catalytic residues [active]
718252000702	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
718252000703	Synaptic Flat tetramer interface [polypeptide binding]; other site
718252000704	Synaptic Site I dimer interface [polypeptide binding]; other site
718252000705	DNA binding site [nucleotide binding]
718252000706	Recombinase; Region: Recombinase; pfam07508
718252000707	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252000708	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718252000709	PLD-like domain; Region: PLDc_2; pfam13091
718252000710	putative active site [active]
718252000711	catalytic site [active]
718252000712	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
718252000713	putative active site [active]
718252000714	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252000715	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
718252000716	ATP binding site [chemical binding]; other site
718252000717	putative Mg++ binding site [ion binding]; other site
718252000718	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252000719	nucleotide binding region [chemical binding]; other site
718252000720	ATP-binding site [chemical binding]; other site
718252000721	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
718252000722	PLD-like domain; Region: PLDc_2; pfam13091
718252000723	homodimer interface [polypeptide binding]; other site
718252000724	putative active site [active]
718252000725	catalytic site [active]
718252000726	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
718252000727	catalytic triad [active]
718252000728	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
718252000729	conserved cis-peptide bond; other site
718252000730	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
718252000731	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
718252000732	DNA binding residues [nucleotide binding]
718252000733	dimer interface [polypeptide binding]; other site
718252000734	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
718252000735	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
718252000736	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
718252000737	non-heme iron binding site [ion binding]; other site
718252000738	dimer interface [polypeptide binding]; other site
718252000739	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
718252000740	non-heme iron binding site [ion binding]; other site
718252000741	Protein of unknown function (DUF523); Region: DUF523; pfam04463
718252000742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252000743	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718252000744	active site
718252000745	motif I; other site
718252000746	motif II; other site
718252000747	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718252000748	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
718252000749	Low molecular weight phosphatase family; Region: LMWPc; cd00115
718252000750	active site
718252000751	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
718252000752	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718252000753	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cd02407
718252000754	peptidyl-tRNA hydrolase; Provisional; Region: PRK04322
718252000755	dimer interface [polypeptide binding]; other site
718252000756	putative active site [active]
718252000757	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
718252000758	Uncharacterized conserved protein [Function unknown]; Region: COG1479
718252000759	Protein of unknown function DUF262; Region: DUF262; pfam03235
718252000760	Uncharacterized conserved protein [Function unknown]; Region: COG3472
718252000761	purine nucleoside phosphorylase; Provisional; Region: PRK08202
718252000762	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
718252000763	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252000764	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718252000765	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
718252000766	putative dimer interface [polypeptide binding]; other site
718252000767	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
718252000768	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718252000769	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
718252000770	active site
718252000771	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
718252000772	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
718252000773	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
718252000774	Walker A/P-loop; other site
718252000775	ATP binding site [chemical binding]; other site
718252000776	Q-loop/lid; other site
718252000777	ABC transporter signature motif; other site
718252000778	Walker B; other site
718252000779	D-loop; other site
718252000780	H-loop/switch region; other site
718252000781	FeS assembly protein SufB; Region: sufB; TIGR01980
718252000782	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
718252000783	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
718252000784	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
718252000785	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
718252000786	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
718252000787	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252000788	catalytic residue [active]
718252000789	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
718252000790	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
718252000791	trimerization site [polypeptide binding]; other site
718252000792	active site
718252000793	Resolvase, N terminal domain; Region: Resolvase; smart00857
718252000794	catalytic nucleophile [active]
718252000795	methionine sulfoxide reductase A; Provisional; Region: PRK05528
718252000796	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252000797	Zn2+ binding site [ion binding]; other site
718252000798	Mg2+ binding site [ion binding]; other site
718252000799	Fic family protein [Function unknown]; Region: COG3177
718252000800	Fic/DOC family; Region: Fic; pfam02661
718252000801	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
718252000802	active site
718252000803	8-oxo-dGMP binding site [chemical binding]; other site
718252000804	nudix motif; other site
718252000805	metal binding site [ion binding]; metal-binding site
718252000806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718252000807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718252000808	MFS/sugar transport protein; Region: MFS_2; pfam13347
718252000809	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718252000810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252000811	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252000812	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252000813	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252000814	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252000815	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252000816	PemK-like protein; Region: PemK; pfam02452
718252000817	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718252000818	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
718252000819	putative dimer interface [polypeptide binding]; other site
718252000820	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252000821	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252000822	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718252000823	Walker A/P-loop; other site
718252000824	ATP binding site [chemical binding]; other site
718252000825	Q-loop/lid; other site
718252000826	ABC transporter signature motif; other site
718252000827	Walker B; other site
718252000828	D-loop; other site
718252000829	H-loop/switch region; other site
718252000830	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
718252000831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252000832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252000833	Walker A/P-loop; other site
718252000834	ATP binding site [chemical binding]; other site
718252000835	Q-loop/lid; other site
718252000836	ABC transporter signature motif; other site
718252000837	Walker B; other site
718252000838	D-loop; other site
718252000839	H-loop/switch region; other site
718252000840	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
718252000841	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718252000842	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252000843	catalytic residue [active]
718252000844	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718252000845	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
718252000846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252000847	FeS/SAM binding site; other site
718252000848	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718252000849	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
718252000850	Helix-turn-helix domain; Region: HTH_38; pfam13936
718252000851	HD domain; Region: HD; pfam01966
718252000852	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252000853	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252000854	catalytic residues [active]
718252000855	catalytic nucleophile [active]
718252000856	Recombinase; Region: Recombinase; pfam07508
718252000857	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252000858	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252000859	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252000860	DNA binding residues [nucleotide binding]
718252000861	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
718252000862	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
718252000863	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
718252000864	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252000865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252000866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252000867	Walker A/P-loop; other site
718252000868	ATP binding site [chemical binding]; other site
718252000869	Q-loop/lid; other site
718252000870	ABC transporter signature motif; other site
718252000871	Walker B; other site
718252000872	D-loop; other site
718252000873	H-loop/switch region; other site
718252000874	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252000875	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252000876	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
718252000877	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252000878	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252000879	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252000880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252000881	non-specific DNA binding site [nucleotide binding]; other site
718252000882	salt bridge; other site
718252000883	sequence-specific DNA binding site [nucleotide binding]; other site
718252000884	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252000885	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252000886	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
718252000887	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252000888	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252000889	PrgI family protein; Region: PrgI; pfam12666
718252000890	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
718252000891	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
718252000892	DNA methylase; Region: N6_N4_Mtase; pfam01555
718252000893	SpoVG; Region: SpoVG; cl00915
718252000894	hypothetical protein; Validated; Region: PRK08116
718252000895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252000896	Walker A motif; other site
718252000897	ATP binding site [chemical binding]; other site
718252000898	Walker B motif; other site
718252000899	arginine finger; other site
718252000900	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718252000901	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
718252000902	T-DNA border endonuclease VirD1; Region: VirD1; cl17530
718252000903	Helix-turn-helix domain; Region: HTH_16; pfam12645
718252000904	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252000905	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
718252000906	DNA binding residues [nucleotide binding]
718252000907	Methyltransferase domain; Region: Methyltransf_31; pfam13847
718252000908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252000909	S-adenosylmethionine binding site [chemical binding]; other site
718252000910	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
718252000911	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
718252000912	G1 box; other site
718252000913	putative GEF interaction site [polypeptide binding]; other site
718252000914	GTP/Mg2+ binding site [chemical binding]; other site
718252000915	Switch I region; other site
718252000916	G2 box; other site
718252000917	G3 box; other site
718252000918	Switch II region; other site
718252000919	G4 box; other site
718252000920	G5 box; other site
718252000921	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
718252000922	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
718252000923	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
718252000924	Maff2 family; Region: Maff2; pfam12750
718252000925	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
718252000926	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252000927	Walker A motif; other site
718252000928	ATP binding site [chemical binding]; other site
718252000929	Walker B motif; other site
718252000930	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252000931	Antirestriction protein (ArdA); Region: ArdA; pfam07275
718252000932	ParB-like nuclease domain; Region: ParBc; pfam02195
718252000933	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
718252000934	sequence-specific DNA binding site [nucleotide binding]; other site
718252000935	salt bridge; other site
718252000936	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
718252000937	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
718252000938	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
718252000939	active site
718252000940	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
718252000941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252000942	Walker A motif; other site
718252000943	ATP binding site [chemical binding]; other site
718252000944	Walker B motif; other site
718252000945	arginine finger; other site
718252000946	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252000947	Walker A motif; other site
718252000948	ATP binding site [chemical binding]; other site
718252000949	Walker B motif; other site
718252000950	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718252000951	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
718252000952	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
718252000953	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
718252000954	active site
718252000955	FMN binding site [chemical binding]; other site
718252000956	substrate binding site [chemical binding]; other site
718252000957	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718252000958	MarR family; Region: MarR_2; pfam12802
718252000959	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
718252000960	oligomerisation interface [polypeptide binding]; other site
718252000961	mobile loop; other site
718252000962	roof hairpin; other site
718252000963	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
718252000964	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
718252000965	ring oligomerisation interface [polypeptide binding]; other site
718252000966	ATP/Mg binding site [chemical binding]; other site
718252000967	stacking interactions; other site
718252000968	hinge regions; other site
718252000969	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
718252000970	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718252000971	Preprotein translocase SecG subunit; Region: SecG; cl09123
718252000972	ribonuclease R; Region: RNase_R; TIGR02063
718252000973	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
718252000974	RNB domain; Region: RNB; pfam00773
718252000975	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
718252000976	RNA binding site [nucleotide binding]; other site
718252000977	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718252000978	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252000979	Coenzyme A binding pocket [chemical binding]; other site
718252000980	myosin-cross-reactive antigen; Provisional; Region: PRK13977
718252000981	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
718252000982	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
718252000983	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
718252000984	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718252000985	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718252000986	dimer interface [polypeptide binding]; other site
718252000987	ssDNA binding site [nucleotide binding]; other site
718252000988	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718252000989	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
718252000990	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
718252000991	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
718252000992	active site
718252000993	tetramer interface; other site
718252000994	Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446
718252000995	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
718252000996	peptide chain release factor 2; Validated; Region: prfB; PRK00578
718252000997	PCRF domain; Region: PCRF; pfam03462
718252000998	RF-1 domain; Region: RF-1; pfam00472
718252000999	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
718252001000	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
718252001001	EDD domain protein, DegV family; Region: DegV; TIGR00762
718252001002	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718252001003	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
718252001004	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
718252001005	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
718252001006	putative active site [active]
718252001007	catalytic site [active]
718252001008	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
718252001009	putative active site [active]
718252001010	catalytic site [active]
718252001011	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718252001012	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718252001013	substrate binding pocket [chemical binding]; other site
718252001014	membrane-bound complex binding site; other site
718252001015	hinge residues; other site
718252001016	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
718252001017	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718252001018	Walker A/P-loop; other site
718252001019	ATP binding site [chemical binding]; other site
718252001020	Q-loop/lid; other site
718252001021	ABC transporter signature motif; other site
718252001022	Walker B; other site
718252001023	D-loop; other site
718252001024	H-loop/switch region; other site
718252001025	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252001026	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718252001027	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
718252001028	AAA domain; Region: AAA_30; pfam13604
718252001029	Family description; Region: UvrD_C_2; pfam13538
718252001030	rod shape-determining protein MreB; Provisional; Region: PRK13930
718252001031	MreB and similar proteins; Region: MreB_like; cd10225
718252001032	putative protofilament interaction site [polypeptide binding]; other site
718252001033	nucleotide binding site [chemical binding]; other site
718252001034	RodZ interaction site [polypeptide binding]; other site
718252001035	Mg binding site [ion binding]; other site
718252001036	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
718252001037	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
718252001038	Part of AAA domain; Region: AAA_19; pfam13245
718252001039	Family description; Region: UvrD_C_2; pfam13538
718252001040	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
718252001041	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
718252001042	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
718252001043	TMP-binding site; other site
718252001044	ATP-binding site [chemical binding]; other site
718252001045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718252001046	YceG-like family; Region: YceG; pfam02618
718252001047	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
718252001048	dimerization interface [polypeptide binding]; other site
718252001049	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718252001050	Peptidase family U32; Region: Peptidase_U32; pfam01136
718252001051	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
718252001052	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
718252001053	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
718252001054	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
718252001055	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718252001056	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718252001057	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252001058	DNA-binding site [nucleotide binding]; DNA binding site
718252001059	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718252001060	UTRA domain; Region: UTRA; pfam07702
718252001061	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718252001062	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252001063	6-phosphofructokinase; Provisional; Region: PRK14072
718252001064	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718252001065	active site
718252001066	ADP/pyrophosphate binding site [chemical binding]; other site
718252001067	dimerization interface [polypeptide binding]; other site
718252001068	allosteric effector site; other site
718252001069	fructose-1,6-bisphosphate binding site; other site
718252001070	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
718252001071	active site
718252001072	ADP/pyrophosphate binding site [chemical binding]; other site
718252001073	allosteric effector site; other site
718252001074	dimerization interface [polypeptide binding]; other site
718252001075	fructose-1,6-bisphosphate binding site; other site
718252001076	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718252001077	active site
718252001078	catalytic triad [active]
718252001079	oxyanion hole [active]
718252001080	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
718252001081	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
718252001082	G1 box; other site
718252001083	putative GEF interaction site [polypeptide binding]; other site
718252001084	GTP/Mg2+ binding site [chemical binding]; other site
718252001085	Switch I region; other site
718252001086	G2 box; other site
718252001087	G3 box; other site
718252001088	Switch II region; other site
718252001089	G4 box; other site
718252001090	G5 box; other site
718252001091	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
718252001092	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
718252001093	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
718252001094	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
718252001095	Beta-Casp domain; Region: Beta-Casp; smart01027
718252001096	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
718252001097	Peptidase M15; Region: Peptidase_M15_3; cl01194
718252001098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
718252001099	RelB antitoxin; Region: RelB; cl01171
718252001100	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
718252001101	putative nucleotide binding site [chemical binding]; other site
718252001102	uridine monophosphate binding site [chemical binding]; other site
718252001103	homohexameric interface [polypeptide binding]; other site
718252001104	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
718252001105	ribosome recycling factor; Reviewed; Region: frr; PRK00083
718252001106	hinge region; other site
718252001107	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
718252001108	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
718252001109	catalytic residue [active]
718252001110	putative FPP diphosphate  binding site; other site
718252001111	putative FPP binding hydrophobic cleft; other site
718252001112	dimer interface [polypeptide binding]; other site
718252001113	putative IPP diphosphate binding site; other site
718252001114	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
718252001115	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
718252001116	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
718252001117	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
718252001118	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
718252001119	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
718252001120	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
718252001121	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
718252001122	active site
718252001123	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
718252001124	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
718252001125	putative substrate binding region [chemical binding]; other site
718252001126	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
718252001127	GcpE protein; Region: GcpE; pfam04551
718252001128	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
718252001129	DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176
718252001130	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
718252001131	generic binding surface II; other site
718252001132	generic binding surface I; other site
718252001133	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
718252001134	active site
718252001135	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
718252001136	active site
718252001137	catalytic site [active]
718252001138	substrate binding site [chemical binding]; other site
718252001139	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
718252001140	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
718252001141	DAK2 domain; Region: Dak2; pfam02734
718252001142	Asp23 family; Region: Asp23; pfam03780
718252001143	FOG: CBS domain [General function prediction only]; Region: COG0517
718252001144	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
718252001145	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
718252001146	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718252001147	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718252001148	PhoU domain; Region: PhoU; pfam01895
718252001149	PhoU domain; Region: PhoU; pfam01895
718252001150	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
718252001151	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
718252001152	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
718252001153	homoserine kinase; Provisional; Region: PRK01212
718252001154	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718252001155	aspartate kinase; Reviewed; Region: PRK06635
718252001156	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
718252001157	putative nucleotide binding site [chemical binding]; other site
718252001158	putative catalytic residues [active]
718252001159	putative Mg ion binding site [ion binding]; other site
718252001160	putative aspartate binding site [chemical binding]; other site
718252001161	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
718252001162	putative allosteric regulatory site; other site
718252001163	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
718252001164	putative allosteric regulatory residue; other site
718252001165	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
718252001166	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
718252001167	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718252001168	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
718252001169	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
718252001170	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718252001171	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
718252001172	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
718252001173	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
718252001174	GTPase CgtA; Reviewed; Region: obgE; PRK12297
718252001175	GTP1/OBG; Region: GTP1_OBG; pfam01018
718252001176	Obg GTPase; Region: Obg; cd01898
718252001177	G1 box; other site
718252001178	GTP/Mg2+ binding site [chemical binding]; other site
718252001179	Switch I region; other site
718252001180	G2 box; other site
718252001181	G3 box; other site
718252001182	Switch II region; other site
718252001183	G4 box; other site
718252001184	G5 box; other site
718252001185	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
718252001186	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
718252001187	active site
718252001188	metal binding site [ion binding]; metal-binding site
718252001189	dimerization interface [polypeptide binding]; other site
718252001190	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
718252001191	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
718252001192	Uncharacterized conserved protein [Function unknown]; Region: COG3270
718252001193	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
718252001194	hypothetical protein; Validated; Region: PRK00110
718252001195	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718252001196	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
718252001197	active site
718252001198	ATP binding site [chemical binding]; other site
718252001199	substrate binding site [chemical binding]; other site
718252001200	activation loop (A-loop); other site
718252001201	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718252001202	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718252001203	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
718252001204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
718252001205	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
718252001206	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
718252001207	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
718252001208	Peptidase family M50; Region: Peptidase_M50; pfam02163
718252001209	active site
718252001210	putative substrate binding region [chemical binding]; other site
718252001211	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
718252001212	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
718252001213	RelB antitoxin; Region: RelB; cl01171
718252001214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
718252001215	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
718252001216	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
718252001217	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252001218	RNA binding surface [nucleotide binding]; other site
718252001219	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
718252001220	active site
718252001221	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
718252001222	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718252001223	carboxyltransferase (CT) interaction site; other site
718252001224	biotinylation site [posttranslational modification]; other site
718252001225	oxaloacetate decarboxylase; Provisional; Region: PRK12331
718252001226	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
718252001227	active site
718252001228	catalytic residues [active]
718252001229	metal binding site [ion binding]; metal-binding site
718252001230	homodimer binding site [polypeptide binding]; other site
718252001231	hypothetical protein; Provisional; Region: PRK11820
718252001232	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
718252001233	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
718252001234	Domain of unknown function (DUF370); Region: DUF370; cl00898
718252001235	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
718252001236	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
718252001237	catalytic site [active]
718252001238	G-X2-G-X-G-K; other site
718252001239	primosome assembly protein PriA; Validated; Region: PRK05580
718252001240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252001241	ATP binding site [chemical binding]; other site
718252001242	putative Mg++ binding site [ion binding]; other site
718252001243	helicase superfamily c-terminal domain; Region: HELICc; smart00490
718252001244	ATP-binding site [chemical binding]; other site
718252001245	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
718252001246	active site
718252001247	catalytic residues [active]
718252001248	metal binding site [ion binding]; metal-binding site
718252001249	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
718252001250	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
718252001251	putative active site [active]
718252001252	substrate binding site [chemical binding]; other site
718252001253	putative cosubstrate binding site; other site
718252001254	catalytic site [active]
718252001255	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
718252001256	substrate binding site [chemical binding]; other site
718252001257	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
718252001258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252001259	FeS/SAM binding site; other site
718252001260	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
718252001261	active site
718252001262	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
718252001263	Catalytic domain of Protein Kinases; Region: PKc; cd00180
718252001264	active site
718252001265	ATP binding site [chemical binding]; other site
718252001266	substrate binding site [chemical binding]; other site
718252001267	activation loop (A-loop); other site
718252001268	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718252001269	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718252001270	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
718252001271	GTPase RsgA; Reviewed; Region: PRK00098
718252001272	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
718252001273	RNA binding site [nucleotide binding]; other site
718252001274	homodimer interface [polypeptide binding]; other site
718252001275	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
718252001276	GTPase/Zn-binding domain interface [polypeptide binding]; other site
718252001277	GTP/Mg2+ binding site [chemical binding]; other site
718252001278	G4 box; other site
718252001279	G5 box; other site
718252001280	G1 box; other site
718252001281	Switch I region; other site
718252001282	G2 box; other site
718252001283	G3 box; other site
718252001284	Switch II region; other site
718252001285	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
718252001286	Thiamine pyrophosphokinase; Region: TPK; cd07995
718252001287	active site
718252001288	dimerization interface [polypeptide binding]; other site
718252001289	thiamine binding site [chemical binding]; other site
718252001290	AAA domain; Region: AAA_25; pfam13481
718252001291	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252001292	Walker A motif; other site
718252001293	ATP binding site [chemical binding]; other site
718252001294	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
718252001295	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
718252001296	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718252001297	xanthine permease; Region: pbuX; TIGR03173
718252001298	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
718252001299	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718252001300	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
718252001301	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252001302	motif II; other site
718252001303	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
718252001304	Sulfatase; Region: Sulfatase; pfam00884
718252001305	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
718252001306	rRNA interaction site [nucleotide binding]; other site
718252001307	S8 interaction site; other site
718252001308	putative laminin-1 binding site; other site
718252001309	elongation factor Ts; Provisional; Region: tsf; PRK09377
718252001310	UBA/TS-N domain; Region: UBA; pfam00627
718252001311	Elongation factor TS; Region: EF_TS; pfam00889
718252001312	Elongation factor TS; Region: EF_TS; pfam00889
718252001313	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252001314	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718252001315	Coenzyme A binding pocket [chemical binding]; other site
718252001316	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
718252001317	Carbon starvation protein CstA; Region: CstA; pfam02554
718252001318	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
718252001319	Trp repressor protein; Region: Trp_repressor; cl17266
718252001320	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718252001321	active site
718252001322	catalytic triad [active]
718252001323	oxyanion hole [active]
718252001324	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
718252001325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252001326	motif II; other site
718252001327	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
718252001328	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718252001329	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718252001330	ABC transporter; Region: ABC_tran_2; pfam12848
718252001331	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718252001332	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
718252001333	Found in ATP-dependent protease La (LON); Region: LON; smart00464
718252001334	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
718252001335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252001336	Walker A motif; other site
718252001337	ATP binding site [chemical binding]; other site
718252001338	Walker B motif; other site
718252001339	arginine finger; other site
718252001340	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
718252001341	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
718252001342	G1 box; other site
718252001343	GTP/Mg2+ binding site [chemical binding]; other site
718252001344	Switch I region; other site
718252001345	G2 box; other site
718252001346	G3 box; other site
718252001347	Switch II region; other site
718252001348	G4 box; other site
718252001349	G5 box; other site
718252001350	Methyltransferase domain; Region: Methyltransf_23; pfam13489
718252001351	Methyltransferase domain; Region: Methyltransf_18; pfam12847
718252001352	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
718252001353	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
718252001354	dimerization interface [polypeptide binding]; other site
718252001355	domain crossover interface; other site
718252001356	redox-dependent activation switch; other site
718252001357	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
718252001358	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
718252001359	Phage lysis protein, holin; Region: Phage_holin; cl04675
718252001360	RelB antitoxin; Region: RelB; cl01171
718252001361	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
718252001362	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
718252001363	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
718252001364	Minor capsid protein; Region: Minor_capsid_2; pfam11114
718252001365	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
718252001366	expansin A; Provisional; Region: PLN00050
718252001367	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
718252001368	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
718252001369	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
718252001370	DNA methylase; Region: N6_N4_Mtase; pfam01555
718252001371	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718252001372	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718252001373	dimer interface [polypeptide binding]; other site
718252001374	ssDNA binding site [nucleotide binding]; other site
718252001375	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718252001376	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
718252001377	Helix-turn-helix domain; Region: HTH_17; cl17695
718252001378	Prophage antirepressor [Transcription]; Region: COG3617
718252001379	BRO family, N-terminal domain; Region: Bro-N; smart01040
718252001380	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
718252001381	non-specific DNA binding site [nucleotide binding]; other site
718252001382	salt bridge; other site
718252001383	sequence-specific DNA binding site [nucleotide binding]; other site
718252001384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252001385	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
718252001386	non-specific DNA binding site [nucleotide binding]; other site
718252001387	salt bridge; other site
718252001388	sequence-specific DNA binding site [nucleotide binding]; other site
718252001389	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718252001390	Catalytic site [active]
718252001391	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
718252001392	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
718252001393	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252001394	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
718252001395	Ligand Binding Site [chemical binding]; other site
718252001396	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
718252001397	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
718252001398	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252001399	catalytic residue [active]
718252001400	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
718252001401	Rubredoxin [Energy production and conversion]; Region: COG1773
718252001402	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
718252001403	iron binding site [ion binding]; other site
718252001404	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
718252001405	Rubrerythrin [Energy production and conversion]; Region: COG1592
718252001406	diiron binding motif [ion binding]; other site
718252001407	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
718252001408	Ligand binding site; other site
718252001409	metal-binding site
718252001410	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
718252001411	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
718252001412	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
718252001413	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718252001414	catalytic loop [active]
718252001415	iron binding site [ion binding]; other site
718252001416	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
718252001417	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
718252001418	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
718252001419	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
718252001420	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
718252001421	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
718252001422	selenophosphate synthetase; Provisional; Region: PRK00943
718252001423	dimerization interface [polypeptide binding]; other site
718252001424	putative ATP binding site [chemical binding]; other site
718252001425	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
718252001426	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
718252001427	CPxP  motif; other site
718252001428	DsrE/DsrF-like family; Region: DrsE; pfam02635
718252001429	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
718252001430	XdhC Rossmann domain; Region: XdhC_C; pfam13478
718252001431	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
718252001432	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
718252001433	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
718252001434	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
718252001435	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
718252001436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718252001437	NAD(P) binding site [chemical binding]; other site
718252001438	active site
718252001439	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
718252001440	AzlC protein; Region: AzlC; pfam03591
718252001441	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
718252001442	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718252001443	minor groove reading motif; other site
718252001444	helix-hairpin-helix signature motif; other site
718252001445	substrate binding pocket [chemical binding]; other site
718252001446	active site
718252001447	recombination factor protein RarA; Reviewed; Region: PRK13342
718252001448	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252001449	Walker A motif; other site
718252001450	ATP binding site [chemical binding]; other site
718252001451	Walker B motif; other site
718252001452	arginine finger; other site
718252001453	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
718252001454	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
718252001455	metal binding site 2 [ion binding]; metal-binding site
718252001456	putative DNA binding helix; other site
718252001457	metal binding site 1 [ion binding]; metal-binding site
718252001458	dimer interface [polypeptide binding]; other site
718252001459	structural Zn2+ binding site [ion binding]; other site
718252001460	Protein of unknown function (DUF964); Region: DUF964; cl01483
718252001461	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
718252001462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252001463	ATP binding site [chemical binding]; other site
718252001464	Mg2+ binding site [ion binding]; other site
718252001465	G-X-G motif; other site
718252001466	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
718252001467	ATP binding site [chemical binding]; other site
718252001468	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
718252001469	Protein of unknown function (DUF552); Region: DUF552; pfam04472
718252001470	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
718252001471	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252001472	RNA binding surface [nucleotide binding]; other site
718252001473	DivIVA protein; Region: DivIVA; pfam05103
718252001474	DivIVA domain; Region: DivI1A_domain; TIGR03544
718252001475	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
718252001476	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
718252001477	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718252001478	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252001479	RNA binding surface [nucleotide binding]; other site
718252001480	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718252001481	active site
718252001482	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
718252001483	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
718252001484	polyphosphate kinase; Provisional; Region: PRK05443
718252001485	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
718252001486	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
718252001487	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718252001488	putative active site [active]
718252001489	catalytic site [active]
718252001490	Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169
718252001491	putative domain interface [polypeptide binding]; other site
718252001492	putative active site [active]
718252001493	catalytic site [active]
718252001494	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
718252001495	active site
718252001496	putative substrate binding region [chemical binding]; other site
718252001497	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
718252001498	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
718252001499	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
718252001500	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
718252001501	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
718252001502	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
718252001503	Catalytic site [active]
718252001504	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
718252001505	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
718252001506	GTP/Mg2+ binding site [chemical binding]; other site
718252001507	G4 box; other site
718252001508	G5 box; other site
718252001509	G1 box; other site
718252001510	Switch I region; other site
718252001511	G2 box; other site
718252001512	Protein of unknown function (DUF1647); Region: DUF1647; pfam07801
718252001513	G3 box; other site
718252001514	Switch II region; other site
718252001515	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
718252001516	RNA/DNA hybrid binding site [nucleotide binding]; other site
718252001517	active site
718252001518	hypothetical protein; Reviewed; Region: PRK12497
718252001519	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
718252001520	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
718252001521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252001522	catalytic residue [active]
718252001523	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
718252001524	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718252001525	active site
718252001526	metal binding site [ion binding]; metal-binding site
718252001527	trigger factor; Provisional; Region: tig; PRK01490
718252001528	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718252001529	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718252001530	Clp protease; Region: CLP_protease; pfam00574
718252001531	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
718252001532	oligomer interface [polypeptide binding]; other site
718252001533	active site residues [active]
718252001534	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
718252001535	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
718252001536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252001537	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
718252001538	Walker A motif; other site
718252001539	ATP binding site [chemical binding]; other site
718252001540	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718252001541	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
718252001542	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718252001543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252001544	catalytic residue [active]
718252001545	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
718252001546	Protein export membrane protein; Region: SecD_SecF; cl14618
718252001547	Protein export membrane protein; Region: SecD_SecF; cl14618
718252001548	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
718252001549	ATP cone domain; Region: ATP-cone; pfam03477
718252001550	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
718252001551	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252001552	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252001553	dimer interface [polypeptide binding]; other site
718252001554	phosphorylation site [posttranslational modification]
718252001555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252001556	ATP binding site [chemical binding]; other site
718252001557	Mg2+ binding site [ion binding]; other site
718252001558	G-X-G motif; other site
718252001559	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252001560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252001561	active site
718252001562	phosphorylation site [posttranslational modification]
718252001563	intermolecular recognition site; other site
718252001564	dimerization interface [polypeptide binding]; other site
718252001565	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252001566	DNA binding site [nucleotide binding]
718252001567	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
718252001568	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718252001569	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718252001570	PhoU domain; Region: PhoU; pfam01895
718252001571	PhoU domain; Region: PhoU; pfam01895
718252001572	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
718252001573	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
718252001574	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
718252001575	Hpr binding site; other site
718252001576	active site
718252001577	homohexamer subunit interaction site [polypeptide binding]; other site
718252001578	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
718252001579	FAD binding domain; Region: FAD_binding_4; pfam01565
718252001580	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
718252001581	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
718252001582	AAA domain; Region: AAA_33; pfam13671
718252001583	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
718252001584	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
718252001585	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
718252001586	active site
718252001587	PHP Thumb interface [polypeptide binding]; other site
718252001588	metal binding site [ion binding]; metal-binding site
718252001589	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
718252001590	generic binding surface II; other site
718252001591	generic binding surface I; other site
718252001592	6-phosphofructokinase; Provisional; Region: PRK03202
718252001593	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718252001594	active site
718252001595	ADP/pyrophosphate binding site [chemical binding]; other site
718252001596	dimerization interface [polypeptide binding]; other site
718252001597	allosteric effector site; other site
718252001598	fructose-1,6-bisphosphate binding site; other site
718252001599	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
718252001600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252001601	Walker A motif; other site
718252001602	ATP binding site [chemical binding]; other site
718252001603	Walker B motif; other site
718252001604	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
718252001605	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
718252001606	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
718252001607	Asp23 family; Region: Asp23; pfam03780
718252001608	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
718252001609	putative RNA binding site [nucleotide binding]; other site
718252001610	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
718252001611	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
718252001612	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
718252001613	substrate binding pocket [chemical binding]; other site
718252001614	chain length determination region; other site
718252001615	substrate-Mg2+ binding site; other site
718252001616	catalytic residues [active]
718252001617	aspartate-rich region 1; other site
718252001618	active site lid residues [active]
718252001619	aspartate-rich region 2; other site
718252001620	Divergent PAP2 family; Region: DUF212; pfam02681
718252001621	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
718252001622	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
718252001623	TPP-binding site; other site
718252001624	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718252001625	PYR/PP interface [polypeptide binding]; other site
718252001626	dimer interface [polypeptide binding]; other site
718252001627	TPP binding site [chemical binding]; other site
718252001628	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718252001629	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
718252001630	ATP-NAD kinase; Region: NAD_kinase; pfam01513
718252001631	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
718252001632	arginine repressor; Provisional; Region: argR; PRK00441
718252001633	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
718252001634	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
718252001635	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
718252001636	Walker A/P-loop; other site
718252001637	ATP binding site [chemical binding]; other site
718252001638	Q-loop/lid; other site
718252001639	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
718252001640	Q-loop/lid; other site
718252001641	ABC transporter signature motif; other site
718252001642	Walker B; other site
718252001643	D-loop; other site
718252001644	H-loop/switch region; other site
718252001645	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
718252001646	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
718252001647	active site
718252001648	HIGH motif; other site
718252001649	dimer interface [polypeptide binding]; other site
718252001650	KMSKS motif; other site
718252001651	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252001652	RNA binding surface [nucleotide binding]; other site
718252001653	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
718252001654	putative allosteric regulatory site; other site
718252001655	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
718252001656	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
718252001657	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
718252001658	putative active site [active]
718252001659	putative metal binding site [ion binding]; other site
718252001660	dihydrodipicolinate reductase; Provisional; Region: PRK00048
718252001661	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
718252001662	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
718252001663	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
718252001664	dihydrodipicolinate synthase; Region: dapA; TIGR00674
718252001665	dimer interface [polypeptide binding]; other site
718252001666	active site
718252001667	catalytic residue [active]
718252001668	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
718252001669	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718252001670	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
718252001671	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
718252001672	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
718252001673	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
718252001674	Preprotein translocase subunit; Region: YajC; pfam02699
718252001675	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
718252001676	DNA repair protein RadA; Provisional; Region: PRK11823
718252001677	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252001678	Walker A motif; other site
718252001679	ATP binding site [chemical binding]; other site
718252001680	Walker B motif; other site
718252001681	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
718252001682	Recombination protein O N terminal; Region: RecO_N; pfam11967
718252001683	DNA repair protein RecO; Region: reco; TIGR00613
718252001684	Recombination protein O C terminal; Region: RecO_C; pfam02565
718252001685	metal-binding heat shock protein; Provisional; Region: PRK00016
718252001686	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
718252001687	PhoH-like protein; Region: PhoH; pfam02562
718252001688	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
718252001689	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
718252001690	active site
718252001691	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
718252001692	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
718252001693	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
718252001694	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
718252001695	active site
718252001696	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
718252001697	active site 2 [active]
718252001698	active site 1 [active]
718252001699	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
718252001700	active site 2 [active]
718252001701	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
718252001702	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
718252001703	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718252001704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001705	dimer interface [polypeptide binding]; other site
718252001706	conserved gate region; other site
718252001707	putative PBP binding loops; other site
718252001708	ABC-ATPase subunit interface; other site
718252001709	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
718252001710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001711	dimer interface [polypeptide binding]; other site
718252001712	conserved gate region; other site
718252001713	putative PBP binding loops; other site
718252001714	ABC-ATPase subunit interface; other site
718252001715	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
718252001716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252001717	Walker A/P-loop; other site
718252001718	ATP binding site [chemical binding]; other site
718252001719	Q-loop/lid; other site
718252001720	ABC transporter signature motif; other site
718252001721	Walker B; other site
718252001722	D-loop; other site
718252001723	H-loop/switch region; other site
718252001724	TOBE domain; Region: TOBE_2; pfam08402
718252001725	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
718252001726	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
718252001727	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
718252001728	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
718252001729	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
718252001730	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
718252001731	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718252001732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252001733	active site
718252001734	phosphorylation site [posttranslational modification]
718252001735	intermolecular recognition site; other site
718252001736	dimerization interface [polypeptide binding]; other site
718252001737	LytTr DNA-binding domain; Region: LytTR; smart00850
718252001738	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
718252001739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252001740	active site
718252001741	phosphorylation site [posttranslational modification]
718252001742	intermolecular recognition site; other site
718252001743	dimerization interface [polypeptide binding]; other site
718252001744	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
718252001745	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
718252001746	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
718252001747	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
718252001748	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
718252001749	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
718252001750	oligomer interface [polypeptide binding]; other site
718252001751	putative active site [active]
718252001752	metal binding site [ion binding]; metal-binding site
718252001753	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718252001754	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718252001755	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718252001756	catalytic residue [active]
718252001757	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
718252001758	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
718252001759	CoA-binding site [chemical binding]; other site
718252001760	ATP-binding [chemical binding]; other site
718252001761	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
718252001762	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
718252001763	peptide chain release factor 1; Validated; Region: prfA; PRK00591
718252001764	PCRF domain; Region: PCRF; pfam03462
718252001765	RF-1 domain; Region: RF-1; pfam00472
718252001766	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
718252001767	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
718252001768	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
718252001769	RNA binding site [nucleotide binding]; other site
718252001770	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
718252001771	RNA binding site [nucleotide binding]; other site
718252001772	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
718252001773	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
718252001774	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252001775	active site
718252001776	DNA binding site [nucleotide binding]
718252001777	Int/Topo IB signature motif; other site
718252001778	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252001779	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
718252001780	DNA binding residues [nucleotide binding]
718252001781	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252001782	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252001783	non-specific DNA binding site [nucleotide binding]; other site
718252001784	salt bridge; other site
718252001785	sequence-specific DNA binding site [nucleotide binding]; other site
718252001786	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252001787	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252001788	DNA binding site [nucleotide binding]
718252001789	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
718252001790	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
718252001791	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718252001792	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252001793	Walker A/P-loop; other site
718252001794	ATP binding site [chemical binding]; other site
718252001795	Q-loop/lid; other site
718252001796	ABC transporter signature motif; other site
718252001797	Walker B; other site
718252001798	D-loop; other site
718252001799	H-loop/switch region; other site
718252001800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252001801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252001802	dimer interface [polypeptide binding]; other site
718252001803	phosphorylation site [posttranslational modification]
718252001804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252001805	ATP binding site [chemical binding]; other site
718252001806	Mg2+ binding site [ion binding]; other site
718252001807	G-X-G motif; other site
718252001808	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252001809	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252001810	catalytic residues [active]
718252001811	catalytic nucleophile [active]
718252001812	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
718252001813	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
718252001814	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718252001815	Helix-turn-helix domain; Region: HTH_16; pfam12645
718252001816	Putative zinc-finger; Region: zf-HC2; pfam13490
718252001817	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
718252001818	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252001819	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252001820	DNA binding residues [nucleotide binding]
718252001821	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
718252001822	active site
718252001823	catalytic site [active]
718252001824	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718252001825	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
718252001826	putative substrate binding site [chemical binding]; other site
718252001827	putative ATP binding site [chemical binding]; other site
718252001828	Protein of unknown function, DUF624; Region: DUF624; pfam04854
718252001829	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718252001830	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718252001831	DNA binding site [nucleotide binding]
718252001832	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718252001833	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718252001834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001835	dimer interface [polypeptide binding]; other site
718252001836	conserved gate region; other site
718252001837	ABC-ATPase subunit interface; other site
718252001838	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252001839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001840	dimer interface [polypeptide binding]; other site
718252001841	conserved gate region; other site
718252001842	putative PBP binding loops; other site
718252001843	ABC-ATPase subunit interface; other site
718252001844	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252001845	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
718252001846	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
718252001847	substrate binding [chemical binding]; other site
718252001848	active site
718252001849	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
718252001850	Protein of unknown function, DUF624; Region: DUF624; pfam04854
718252001851	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
718252001852	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
718252001853	Ca binding site [ion binding]; other site
718252001854	active site
718252001855	catalytic site [active]
718252001856	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
718252001857	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
718252001858	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718252001859	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
718252001860	trimer interface [polypeptide binding]; other site
718252001861	active site
718252001862	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
718252001863	catalytic site [active]
718252001864	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252001865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001866	dimer interface [polypeptide binding]; other site
718252001867	conserved gate region; other site
718252001868	putative PBP binding loops; other site
718252001869	ABC-ATPase subunit interface; other site
718252001870	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718252001871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001872	dimer interface [polypeptide binding]; other site
718252001873	conserved gate region; other site
718252001874	putative PBP binding loops; other site
718252001875	ABC-ATPase subunit interface; other site
718252001876	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252001877	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718252001878	Domain of unknown function (DUF955); Region: DUF955; pfam06114
718252001879	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718252001880	galactonate dehydratase; Provisional; Region: PRK14017
718252001881	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718252001882	active site pocket [active]
718252001883	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718252001884	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718252001885	transmembrane helices; other site
718252001886	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252001887	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252001888	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252001889	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252001890	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718252001891	putative catalytic residues [active]
718252001892	catalytic nucleophile [active]
718252001893	Recombinase; Region: Recombinase; pfam07508
718252001894	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252001895	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718252001896	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252001897	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
718252001898	chaperone protein HchA; Provisional; Region: PRK04155
718252001899	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718252001900	ParB-like nuclease domain; Region: ParBc; pfam02195
718252001901	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718252001902	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252001903	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252001904	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252001905	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252001906	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252001907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252001908	non-specific DNA binding site [nucleotide binding]; other site
718252001909	salt bridge; other site
718252001910	sequence-specific DNA binding site [nucleotide binding]; other site
718252001911	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
718252001912	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718252001913	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
718252001914	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
718252001915	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
718252001916	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252001917	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
718252001918	YodL-like; Region: YodL; pfam14191
718252001919	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
718252001920	DNA topoisomerase III; Provisional; Region: PRK07726
718252001921	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
718252001922	active site
718252001923	putative interdomain interaction site [polypeptide binding]; other site
718252001924	putative metal-binding site [ion binding]; other site
718252001925	putative nucleotide binding site [chemical binding]; other site
718252001926	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
718252001927	domain I; other site
718252001928	DNA binding groove [nucleotide binding]
718252001929	phosphate binding site [ion binding]; other site
718252001930	domain II; other site
718252001931	domain III; other site
718252001932	nucleotide binding site [chemical binding]; other site
718252001933	catalytic site [active]
718252001934	domain IV; other site
718252001935	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
718252001936	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
718252001937	AAA domain; Region: AAA_14; pfam13173
718252001938	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252001939	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252001940	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252001941	Maff2 family; Region: Maff2; pfam12750
718252001942	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252001943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252001944	non-specific DNA binding site [nucleotide binding]; other site
718252001945	salt bridge; other site
718252001946	sequence-specific DNA binding site [nucleotide binding]; other site
718252001947	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
718252001948	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252001949	Walker A motif; other site
718252001950	ATP binding site [chemical binding]; other site
718252001951	Walker B motif; other site
718252001952	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252001953	ParB-like nuclease domain; Region: ParBc; pfam02195
718252001954	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252001955	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252001956	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252001957	P-loop; other site
718252001958	Magnesium ion binding site [ion binding]; other site
718252001959	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252001960	Magnesium ion binding site [ion binding]; other site
718252001961	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
718252001962	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
718252001963	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
718252001964	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718252001965	active site
718252001966	catalytic tetrad [active]
718252001967	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252001968	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
718252001969	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
718252001970	FMN binding site [chemical binding]; other site
718252001971	active site
718252001972	catalytic residues [active]
718252001973	substrate binding site [chemical binding]; other site
718252001974	5'-nucleotidase; Provisional; Region: PRK03826
718252001975	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
718252001976	Domain of unknown function, B. Theta Gene description (DUF3873); Region: DUF3873; pfam12989
718252001977	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252001978	Zn2+ binding site [ion binding]; other site
718252001979	Mg2+ binding site [ion binding]; other site
718252001980	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
718252001981	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718252001982	Predicted membrane protein [Function unknown]; Region: COG3601
718252001983	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718252001984	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252001985	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718252001986	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
718252001987	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
718252001988	Mg++ binding site [ion binding]; other site
718252001989	putative catalytic motif [active]
718252001990	putative substrate binding site [chemical binding]; other site
718252001991	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718252001992	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718252001993	substrate binding pocket [chemical binding]; other site
718252001994	membrane-bound complex binding site; other site
718252001995	hinge residues; other site
718252001996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252001997	dimer interface [polypeptide binding]; other site
718252001998	conserved gate region; other site
718252001999	putative PBP binding loops; other site
718252002000	ABC-ATPase subunit interface; other site
718252002001	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718252002002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252002003	dimer interface [polypeptide binding]; other site
718252002004	conserved gate region; other site
718252002005	ABC-ATPase subunit interface; other site
718252002006	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
718252002007	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
718252002008	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
718252002009	homodimer interface [polypeptide binding]; other site
718252002010	NADP binding site [chemical binding]; other site
718252002011	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
718252002012	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
718252002013	S-ribosylhomocysteinase; Provisional; Region: PRK02260
718252002014	pyruvate kinase; Provisional; Region: PRK06354
718252002015	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
718252002016	domain interfaces; other site
718252002017	active site
718252002018	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
718252002019	phosphopentomutase; Provisional; Region: PRK05362
718252002020	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
718252002021	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
718252002022	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
718252002023	NAD synthetase; Reviewed; Region: nadE; PRK02628
718252002024	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
718252002025	multimer interface [polypeptide binding]; other site
718252002026	active site
718252002027	catalytic triad [active]
718252002028	protein interface 1 [polypeptide binding]; other site
718252002029	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
718252002030	homodimer interface [polypeptide binding]; other site
718252002031	NAD binding pocket [chemical binding]; other site
718252002032	ATP binding pocket [chemical binding]; other site
718252002033	Mg binding site [ion binding]; other site
718252002034	active-site loop [active]
718252002035	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718252002036	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718252002037	active site
718252002038	Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813
718252002039	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
718252002040	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718252002041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252002042	Coenzyme A binding pocket [chemical binding]; other site
718252002043	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
718252002044	active site
718252002045	catalytic motif [active]
718252002046	Zn binding site [ion binding]; other site
718252002047	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
718252002048	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718252002049	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718252002050	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
718252002051	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
718252002052	TM-ABC transporter signature motif; other site
718252002053	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718252002054	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
718252002055	TM-ABC transporter signature motif; other site
718252002056	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718252002057	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
718252002058	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
718252002059	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
718252002060	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
718252002061	TrkA-N domain; Region: TrkA_N; pfam02254
718252002062	TrkA-C domain; Region: TrkA_C; pfam02080
718252002063	TrkA-N domain; Region: TrkA_N; pfam02254
718252002064	TrkA-C domain; Region: TrkA_C; pfam02080
718252002065	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
718252002066	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
718252002067	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
718252002068	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
718252002069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252002070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
718252002071	Walker A motif; other site
718252002072	ATP binding site [chemical binding]; other site
718252002073	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
718252002074	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
718252002075	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
718252002076	active site
718252002077	substrate binding site [chemical binding]; other site
718252002078	metal binding site [ion binding]; metal-binding site
718252002079	TIGR00159 family protein; Region: TIGR00159
718252002080	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
718252002081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
718252002082	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
718252002083	Tetrahydromethanopterin S-methyltransferase, subunit D; Region: MtrD; cl01676
718252002084	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
718252002085	DHH family; Region: DHH; pfam01368
718252002086	DHHA1 domain; Region: DHHA1; pfam02272
718252002087	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
718252002088	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252002089	Zn2+ binding site [ion binding]; other site
718252002090	Mg2+ binding site [ion binding]; other site
718252002091	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718252002092	synthetase active site [active]
718252002093	NTP binding site [chemical binding]; other site
718252002094	metal binding site [ion binding]; metal-binding site
718252002095	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
718252002096	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
718252002097	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
718252002098	putative active site [active]
718252002099	dimerization interface [polypeptide binding]; other site
718252002100	putative tRNAtyr binding site [nucleotide binding]; other site
718252002101	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718252002102	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
718252002103	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
718252002104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252002105	FeS/SAM binding site; other site
718252002106	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
718252002107	active site
718252002108	Double zinc ribbon; Region: DZR; pfam12773
718252002109	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
718252002110	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
718252002111	homodimer interface [polypeptide binding]; other site
718252002112	metal binding site [ion binding]; metal-binding site
718252002113	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
718252002114	metal binding site [ion binding]; metal-binding site
718252002115	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718252002116	IHF - DNA interface [nucleotide binding]; other site
718252002117	IHF dimer interface [polypeptide binding]; other site
718252002118	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252002119	RNA binding surface [nucleotide binding]; other site
718252002120	YabP family; Region: YabP; pfam07873
718252002121	Septum formation initiator; Region: DivIC; cl17659
718252002122	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
718252002123	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
718252002124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
718252002125	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
718252002126	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
718252002127	glutaminase active site [active]
718252002128	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
718252002129	dimer interface [polypeptide binding]; other site
718252002130	active site
718252002131	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718252002132	dimer interface [polypeptide binding]; other site
718252002133	active site
718252002134	Bacterial Ig-like domain 2; Region: BID_2; smart00635
718252002135	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718252002136	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718252002137	HlyD family secretion protein; Region: HlyD_3; pfam13437
718252002138	galactinol-raffinose galactosyltransferase/ghydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02982
718252002139	Predicted ATPase [General function prediction only]; Region: COG3910
718252002140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252002141	Walker A/P-loop; other site
718252002142	ATP binding site [chemical binding]; other site
718252002143	Q-loop/lid; other site
718252002144	ABC transporter signature motif; other site
718252002145	Walker B; other site
718252002146	D-loop; other site
718252002147	H-loop/switch region; other site
718252002148	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
718252002149	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
718252002150	YodL-like; Region: YodL; pfam14191
718252002151	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252002152	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252002153	P-loop; other site
718252002154	Magnesium ion binding site [ion binding]; other site
718252002155	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252002156	Magnesium ion binding site [ion binding]; other site
718252002157	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
718252002158	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
718252002159	23S rRNA interface [nucleotide binding]; other site
718252002160	L3 interface [polypeptide binding]; other site
718252002161	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
718252002162	Ligand Binding Site [chemical binding]; other site
718252002163	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
718252002164	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
718252002165	active site
718252002166	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718252002167	dimer interface [polypeptide binding]; other site
718252002168	substrate binding site [chemical binding]; other site
718252002169	catalytic residues [active]
718252002170	GTP-binding protein LepA; Provisional; Region: PRK05433
718252002171	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
718252002172	G1 box; other site
718252002173	putative GEF interaction site [polypeptide binding]; other site
718252002174	GTP/Mg2+ binding site [chemical binding]; other site
718252002175	Switch I region; other site
718252002176	G2 box; other site
718252002177	G3 box; other site
718252002178	Switch II region; other site
718252002179	G4 box; other site
718252002180	G5 box; other site
718252002181	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
718252002182	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
718252002183	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
718252002184	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718252002185	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718252002186	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718252002187	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
718252002188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252002189	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
718252002190	FeS/SAM binding site; other site
718252002191	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
718252002192	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718252002193	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
718252002194	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718252002195	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718252002196	active site
718252002197	O-Antigen ligase; Region: Wzy_C; pfam04932
718252002198	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
718252002199	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718252002200	putative active site [active]
718252002201	putative metal binding site [ion binding]; other site
718252002202	Chain length determinant protein; Region: Wzz; cl15801
718252002203	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718252002204	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718252002205	metal binding site [ion binding]; metal-binding site
718252002206	active site
718252002207	I-site; other site
718252002208	Helix-turn-helix domain; Region: HTH_28; pfam13518
718252002209	Integrase core domain; Region: rve_2; pfam13333
718252002210	D-mannonate oxidoreductase; Provisional; Region: PRK08277
718252002211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718252002212	NAD(P) binding site [chemical binding]; other site
718252002213	active site
718252002214	MFS/sugar transport protein; Region: MFS_2; pfam13347
718252002215	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718252002216	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252002217	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252002218	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252002219	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718252002220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252002221	active site
718252002222	phosphorylation site [posttranslational modification]
718252002223	intermolecular recognition site; other site
718252002224	dimerization interface [polypeptide binding]; other site
718252002225	LytTr DNA-binding domain; Region: LytTR; smart00850
718252002226	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718252002227	active site
718252002228	catalytic triad [active]
718252002229	oxyanion hole [active]
718252002230	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718252002231	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718252002232	nucleotide binding site [chemical binding]; other site
718252002233	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
718252002234	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
718252002235	putative active site cavity [active]
718252002236	Domain of unknown function (DUF386); Region: DUF386; cl01047
718252002237	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
718252002238	Class I aldolases; Region: Aldolase_Class_I; cl17187
718252002239	catalytic residue [active]
718252002240	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252002241	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252002242	dimer interface [polypeptide binding]; other site
718252002243	conserved gate region; other site
718252002244	putative PBP binding loops; other site
718252002245	ABC-ATPase subunit interface; other site
718252002246	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252002247	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718252002248	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718252002249	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718252002250	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718252002251	putative active site [active]
718252002252	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
718252002253	Histidine kinase; Region: His_kinase; pfam06580
718252002254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252002255	ATP binding site [chemical binding]; other site
718252002256	Mg2+ binding site [ion binding]; other site
718252002257	G-X-G motif; other site
718252002258	Response regulator receiver domain; Region: Response_reg; pfam00072
718252002259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252002260	active site
718252002261	phosphorylation site [posttranslational modification]
718252002262	intermolecular recognition site; other site
718252002263	dimerization interface [polypeptide binding]; other site
718252002264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252002265	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252002266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252002267	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
718252002268	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718252002269	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
718252002270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252002271	Walker A/P-loop; other site
718252002272	ATP binding site [chemical binding]; other site
718252002273	Q-loop/lid; other site
718252002274	ABC transporter signature motif; other site
718252002275	Walker B; other site
718252002276	D-loop; other site
718252002277	H-loop/switch region; other site
718252002278	TOBE domain; Region: TOBE_2; pfam08402
718252002279	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
718252002280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252002281	dimer interface [polypeptide binding]; other site
718252002282	conserved gate region; other site
718252002283	putative PBP binding loops; other site
718252002284	ABC-ATPase subunit interface; other site
718252002285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252002286	dimer interface [polypeptide binding]; other site
718252002287	conserved gate region; other site
718252002288	putative PBP binding loops; other site
718252002289	ABC-ATPase subunit interface; other site
718252002290	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
718252002291	CoenzymeA binding site [chemical binding]; other site
718252002292	subunit interaction site [polypeptide binding]; other site
718252002293	PHB binding site; other site
718252002294	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
718252002295	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
718252002296	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
718252002297	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
718252002298	Propionate catabolism activator; Region: PrpR_N; pfam06506
718252002299	PAS fold; Region: PAS; pfam00989
718252002300	PAS domain; Region: PAS; smart00091
718252002301	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
718252002302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252002303	Walker A motif; other site
718252002304	ATP binding site [chemical binding]; other site
718252002305	Walker B motif; other site
718252002306	arginine finger; other site
718252002307	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
718252002308	DNA-binding interface [nucleotide binding]; DNA binding site
718252002309	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
718252002310	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718252002311	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718252002312	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
718252002313	CoA-transferase family III; Region: CoA_transf_3; pfam02515
718252002314	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
718252002315	active site
718252002316	catalytic residues [active]
718252002317	metal binding site [ion binding]; metal-binding site
718252002318	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
718252002319	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
718252002320	Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596
718252002321	Predicted transcriptional regulators [Transcription]; Region: COG1725
718252002322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252002323	DNA-binding site [nucleotide binding]; DNA binding site
718252002324	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718252002325	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718252002326	Walker A/P-loop; other site
718252002327	ATP binding site [chemical binding]; other site
718252002328	Q-loop/lid; other site
718252002329	ABC transporter signature motif; other site
718252002330	Walker B; other site
718252002331	D-loop; other site
718252002332	H-loop/switch region; other site
718252002333	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
718252002334	VanZ like family; Region: VanZ; cl01971
718252002335	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252002336	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252002337	DNA binding residues [nucleotide binding]
718252002338	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252002339	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718252002340	catalytic residues [active]
718252002341	catalytic nucleophile [active]
718252002342	Presynaptic Site I dimer interface [polypeptide binding]; other site
718252002343	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
718252002344	Synaptic Flat tetramer interface [polypeptide binding]; other site
718252002345	Synaptic Site I dimer interface [polypeptide binding]; other site
718252002346	DNA binding site [nucleotide binding]
718252002347	Recombinase; Region: Recombinase; pfam07508
718252002348	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252002349	Helix-turn-helix domain; Region: HTH_28; pfam13518
718252002350	Peptidase family C69; Region: Peptidase_C69; cl17793
718252002351	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
718252002352	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
718252002353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
718252002354	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
718252002355	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
718252002356	RloB-like protein; Region: RloB; pfam13707
718252002357	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252002358	AAA domain; Region: AAA_21; pfam13304
718252002359	Walker A/P-loop; other site
718252002360	ATP binding site [chemical binding]; other site
718252002361	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252002362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002363	non-specific DNA binding site [nucleotide binding]; other site
718252002364	salt bridge; other site
718252002365	sequence-specific DNA binding site [nucleotide binding]; other site
718252002366	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718252002367	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
718252002368	AAA domain; Region: AAA_21; pfam13304
718252002369	pyruvate phosphate dikinase; Provisional; Region: PRK09279
718252002370	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
718252002371	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718252002372	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718252002373	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
718252002374	active site
718252002375	substrate binding site [chemical binding]; other site
718252002376	CoA binding site [chemical binding]; other site
718252002377	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
718252002378	putative active site [active]
718252002379	catalytic residue [active]
718252002380	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
718252002381	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
718252002382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252002383	ATP binding site [chemical binding]; other site
718252002384	putative Mg++ binding site [ion binding]; other site
718252002385	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252002386	nucleotide binding region [chemical binding]; other site
718252002387	ATP-binding site [chemical binding]; other site
718252002388	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
718252002389	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252002390	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252002391	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252002392	aspartate aminotransferase; Provisional; Region: PRK06836
718252002393	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718252002394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252002395	homodimer interface [polypeptide binding]; other site
718252002396	catalytic residue [active]
718252002397	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
718252002398	Cation efflux family; Region: Cation_efflux; pfam01545
718252002399	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718252002400	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
718252002401	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718252002402	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718252002403	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718252002404	dimerization domain swap beta strand [polypeptide binding]; other site
718252002405	regulatory protein interface [polypeptide binding]; other site
718252002406	active site
718252002407	regulatory phosphorylation site [posttranslational modification]; other site
718252002408	K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927
718252002409	putative pectinesterase; Region: PLN02432; cl01911
718252002410	Pectinesterase; Region: Pectinesterase; pfam01095
718252002411	stage II sporulation protein E; Region: spore_II_E; TIGR02865
718252002412	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
718252002413	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
718252002414	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
718252002415	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
718252002416	active site
718252002417	HIGH motif; other site
718252002418	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
718252002419	active site
718252002420	KMSKS motif; other site
718252002421	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
718252002422	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
718252002423	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
718252002424	Protein of unknown function DUF45; Region: DUF45; pfam01863
718252002425	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718252002426	EamA-like transporter family; Region: EamA; pfam00892
718252002427	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
718252002428	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252002429	active site
718252002430	DNA binding site [nucleotide binding]
718252002431	Int/Topo IB signature motif; other site
718252002432	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718252002433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252002434	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252002435	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252002436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252002437	Walker A/P-loop; other site
718252002438	ATP binding site [chemical binding]; other site
718252002439	Q-loop/lid; other site
718252002440	ABC transporter signature motif; other site
718252002441	Walker B; other site
718252002442	D-loop; other site
718252002443	H-loop/switch region; other site
718252002444	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
718252002445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252002446	dimer interface [polypeptide binding]; other site
718252002447	conserved gate region; other site
718252002448	putative PBP binding loops; other site
718252002449	ABC-ATPase subunit interface; other site
718252002450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252002451	ABC transporter signature motif; other site
718252002452	Walker B; other site
718252002453	D-loop; other site
718252002454	H-loop/switch region; other site
718252002455	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
718252002456	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252002457	Walker A/P-loop; other site
718252002458	ATP binding site [chemical binding]; other site
718252002459	Q-loop/lid; other site
718252002460	ABC transporter signature motif; other site
718252002461	Walker B; other site
718252002462	D-loop; other site
718252002463	H-loop/switch region; other site
718252002464	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
718252002465	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718252002466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718252002467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718252002468	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
718252002469	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
718252002470	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
718252002471	G1 box; other site
718252002472	GTP/Mg2+ binding site [chemical binding]; other site
718252002473	Switch I region; other site
718252002474	G2 box; other site
718252002475	G3 box; other site
718252002476	Switch II region; other site
718252002477	G4 box; other site
718252002478	G5 box; other site
718252002479	Nucleoside recognition; Region: Gate; pfam07670
718252002480	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
718252002481	Nucleoside recognition; Region: Gate; pfam07670
718252002482	FeoC like transcriptional regulator; Region: FeoC; cl17677
718252002483	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252002484	metal-binding site [ion binding]
718252002485	Transposase; Region: DEDD_Tnp_IS110; pfam01548
718252002486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
718252002487	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
718252002488	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252002489	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252002490	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252002491	Walker A/P-loop; other site
718252002492	ATP binding site [chemical binding]; other site
718252002493	Q-loop/lid; other site
718252002494	ABC transporter signature motif; other site
718252002495	Walker B; other site
718252002496	D-loop; other site
718252002497	H-loop/switch region; other site
718252002498	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252002499	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252002500	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252002501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252002502	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
718252002503	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718252002504	HipA-like C-terminal domain; Region: HipA_C; pfam07804
718252002505	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252002506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252002507	ATP binding site [chemical binding]; other site
718252002508	G-X-G motif; other site
718252002509	Response regulator receiver domain; Region: Response_reg; pfam00072
718252002510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252002511	active site
718252002512	phosphorylation site [posttranslational modification]
718252002513	intermolecular recognition site; other site
718252002514	dimerization interface [polypeptide binding]; other site
718252002515	CHASE domain; Region: CHASE; cl01369
718252002516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252002517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252002518	dimer interface [polypeptide binding]; other site
718252002519	phosphorylation site [posttranslational modification]
718252002520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002521	non-specific DNA binding site [nucleotide binding]; other site
718252002522	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
718252002523	salt bridge; other site
718252002524	sequence-specific DNA binding site [nucleotide binding]; other site
718252002525	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718252002526	Catalytic site [active]
718252002527	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
718252002528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252002529	FeS/SAM binding site; other site
718252002530	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
718252002531	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
718252002532	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
718252002533	active site
718252002534	WYL domain; Region: WYL; pfam13280
718252002535	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
718252002536	prephenate dehydrogenase; Validated; Region: PRK08507
718252002537	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
718252002538	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
718252002539	hinge; other site
718252002540	active site
718252002541	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
718252002542	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
718252002543	Dehydroquinase class II; Region: DHquinase_II; pfam01220
718252002544	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
718252002545	trimer interface [polypeptide binding]; other site
718252002546	active site
718252002547	dimer interface [polypeptide binding]; other site
718252002548	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
718252002549	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
718252002550	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
718252002551	shikimate binding site; other site
718252002552	NAD(P) binding site [chemical binding]; other site
718252002553	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
718252002554	Shikimate kinase; Region: SKI; pfam01202
718252002555	ADP binding site [chemical binding]; other site
718252002556	magnesium binding site [ion binding]; other site
718252002557	putative shikimate binding site; other site
718252002558	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
718252002559	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
718252002560	Tetramer interface [polypeptide binding]; other site
718252002561	active site
718252002562	FMN-binding site [chemical binding]; other site
718252002563	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
718252002564	active site
718252002565	dimer interface [polypeptide binding]; other site
718252002566	metal binding site [ion binding]; metal-binding site
718252002567	hypothetical protein; Provisional; Region: PRK07248
718252002568	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
718252002569	Prephenate dehydratase; Region: PDT; pfam00800
718252002570	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
718252002571	putative L-Phe binding site [chemical binding]; other site
718252002572	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
718252002573	Protein of unknown function, DUF624; Region: DUF624; cl02369
718252002574	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
718252002575	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
718252002576	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
718252002577	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
718252002578	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718252002579	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718252002580	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718252002581	putative active site [active]
718252002582	stage V sporulation protein K; Region: spore_V_K; TIGR02881
718252002583	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
718252002584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252002585	Walker A motif; other site
718252002586	ATP binding site [chemical binding]; other site
718252002587	Walker B motif; other site
718252002588	arginine finger; other site
718252002589	pullulanase, type I; Region: pulA_typeI; TIGR02104
718252002590	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
718252002591	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
718252002592	Ca binding site [ion binding]; other site
718252002593	active site
718252002594	catalytic site [active]
718252002595	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
718252002596	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
718252002597	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718252002598	protein binding site [polypeptide binding]; other site
718252002599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252002600	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718252002601	Coenzyme A binding pocket [chemical binding]; other site
718252002602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252002603	S-adenosylmethionine binding site [chemical binding]; other site
718252002604	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
718252002605	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
718252002606	G1 box; other site
718252002607	putative GEF interaction site [polypeptide binding]; other site
718252002608	GTP/Mg2+ binding site [chemical binding]; other site
718252002609	Switch I region; other site
718252002610	G2 box; other site
718252002611	G3 box; other site
718252002612	Switch II region; other site
718252002613	G4 box; other site
718252002614	G5 box; other site
718252002615	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
718252002616	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718252002617	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718252002618	active site
718252002619	catalytic tetrad [active]
718252002620	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718252002621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252002622	Coenzyme A binding pocket [chemical binding]; other site
718252002623	Peptidase family M23; Region: Peptidase_M23; pfam01551
718252002624	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
718252002625	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
718252002626	putative dimer interface [polypeptide binding]; other site
718252002627	putative anticodon binding site; other site
718252002628	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
718252002629	homodimer interface [polypeptide binding]; other site
718252002630	motif 1; other site
718252002631	motif 2; other site
718252002632	active site
718252002633	motif 3; other site
718252002634	stage II sporulation protein P; Region: spore_II_P; TIGR02867
718252002635	Germination protease; Region: Peptidase_A25; cl04057
718252002636	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
718252002637	SpoVA protein; Region: SpoVA; cl04298
718252002638	SpoVA protein; Region: SpoVA; cl04298
718252002639	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
718252002640	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
718252002641	DHHW protein; Region: DHHW; pfam14286
718252002642	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
718252002643	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718252002644	HSP70 interaction site [polypeptide binding]; other site
718252002645	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
718252002646	substrate binding site [polypeptide binding]; other site
718252002647	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
718252002648	Zn binding sites [ion binding]; other site
718252002649	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
718252002650	dimer interface [polypeptide binding]; other site
718252002651	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
718252002652	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
718252002653	nucleotide binding site [chemical binding]; other site
718252002654	NEF interaction site [polypeptide binding]; other site
718252002655	SBD interface [polypeptide binding]; other site
718252002656	GrpE; Region: GrpE; pfam01025
718252002657	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
718252002658	dimer interface [polypeptide binding]; other site
718252002659	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
718252002660	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
718252002661	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
718252002662	Flagellar L-ring protein; Region: FlgH; cl17277
718252002663	stage V sporulation protein T; Region: spore_V_T; TIGR02851
718252002664	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
718252002665	flavoprotein, HI0933 family; Region: TIGR00275
718252002666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718252002667	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718252002668	amino acid carrier protein; Region: agcS; TIGR00835
718252002669	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
718252002670	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252002671	DNA-binding site [nucleotide binding]; DNA binding site
718252002672	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718252002673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252002674	homodimer interface [polypeptide binding]; other site
718252002675	catalytic residue [active]
718252002676	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
718252002677	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
718252002678	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252002679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002680	non-specific DNA binding site [nucleotide binding]; other site
718252002681	salt bridge; other site
718252002682	sequence-specific DNA binding site [nucleotide binding]; other site
718252002683	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
718252002684	Methyltransferase domain; Region: Methyltransf_11; pfam08241
718252002685	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718252002686	DEAD-like helicases superfamily; Region: DEXDc; smart00487
718252002687	ATP binding site [chemical binding]; other site
718252002688	Mg++ binding site [ion binding]; other site
718252002689	motif III; other site
718252002690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252002691	nucleotide binding region [chemical binding]; other site
718252002692	ATP-binding site [chemical binding]; other site
718252002693	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
718252002694	Putative glycosyl hydrolase domain; Region: DUF4015; cl17870
718252002695	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
718252002696	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
718252002697	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
718252002698	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
718252002699	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
718252002700	substrate binding site [chemical binding]; other site
718252002701	hexamer interface [polypeptide binding]; other site
718252002702	metal binding site [ion binding]; metal-binding site
718252002703	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252002704	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252002705	dimerization interface [polypeptide binding]; other site
718252002706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252002707	dimer interface [polypeptide binding]; other site
718252002708	phosphorylation site [posttranslational modification]
718252002709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252002710	ATP binding site [chemical binding]; other site
718252002711	Mg2+ binding site [ion binding]; other site
718252002712	G-X-G motif; other site
718252002713	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252002714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252002715	active site
718252002716	phosphorylation site [posttranslational modification]
718252002717	intermolecular recognition site; other site
718252002718	dimerization interface [polypeptide binding]; other site
718252002719	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252002720	DNA binding site [nucleotide binding]
718252002721	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002722	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252002723	non-specific DNA binding site [nucleotide binding]; other site
718252002724	salt bridge; other site
718252002725	sequence-specific DNA binding site [nucleotide binding]; other site
718252002726	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252002727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002728	non-specific DNA binding site [nucleotide binding]; other site
718252002729	salt bridge; other site
718252002730	sequence-specific DNA binding site [nucleotide binding]; other site
718252002731	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
718252002732	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718252002733	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
718252002734	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
718252002735	homotrimer interaction site [polypeptide binding]; other site
718252002736	putative active site [active]
718252002737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
718252002738	YheO-like PAS domain; Region: PAS_6; pfam08348
718252002739	HTH domain; Region: HTH_22; pfam13309
718252002740	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
718252002741	AAA domain; Region: AAA_14; pfam13173
718252002742	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252002743	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252002744	catalytic residues [active]
718252002745	catalytic nucleophile [active]
718252002746	Recombinase; Region: Recombinase; pfam07508
718252002747	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
718252002748	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718252002749	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
718252002750	DNA methylase; Region: N6_N4_Mtase; pfam01555
718252002751	DNA methylase; Region: N6_N4_Mtase; cl17433
718252002752	Prophage antirepressor [Transcription]; Region: COG3617
718252002753	BRO family, N-terminal domain; Region: Bro-N; smart01040
718252002754	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
718252002755	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252002756	Maff2 family; Region: Maff2; pfam12750
718252002757	Maff2 family; Region: Maff2; pfam12750
718252002758	MT-A70; Region: MT-A70; cl01947
718252002759	PrgI family protein; Region: PrgI; pfam12666
718252002760	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252002761	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252002762	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
718252002763	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252002764	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
718252002765	Ligand Binding Site [chemical binding]; other site
718252002766	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
718252002767	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
718252002768	MutS domain I; Region: MutS_I; pfam01624
718252002769	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
718252002770	Antirestriction protein (ArdA); Region: ArdA; pfam07275
718252002771	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
718252002772	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
718252002773	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252002774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002775	non-specific DNA binding site [nucleotide binding]; other site
718252002776	salt bridge; other site
718252002777	sequence-specific DNA binding site [nucleotide binding]; other site
718252002778	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
718252002779	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
718252002780	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
718252002781	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
718252002782	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
718252002783	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252002784	ATP binding site [chemical binding]; other site
718252002785	putative Mg++ binding site [ion binding]; other site
718252002786	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
718252002787	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718252002788	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
718252002789	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718252002790	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
718252002791	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252002792	active site
718252002793	DNA binding site [nucleotide binding]
718252002794	Int/Topo IB signature motif; other site
718252002795	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
718252002796	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718252002797	HsdM N-terminal domain; Region: HsdM_N; pfam12161
718252002798	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
718252002799	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718252002800	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
718252002801	non-specific DNA binding site [nucleotide binding]; other site
718252002802	salt bridge; other site
718252002803	sequence-specific DNA binding site [nucleotide binding]; other site
718252002804	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
718252002805	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
718252002806	metal ion-dependent adhesion site (MIDAS); other site
718252002807	DNA polymerase IV; Reviewed; Region: PRK03103
718252002808	Y-family of DNA polymerases; Region: PolY; cl12025
718252002809	active site
718252002810	DNA binding site [nucleotide binding]
718252002811	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
718252002812	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
718252002813	putative ADP-ribose binding site [chemical binding]; other site
718252002814	putative active site [active]
718252002815	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718252002816	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252002817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002818	non-specific DNA binding site [nucleotide binding]; other site
718252002819	salt bridge; other site
718252002820	sequence-specific DNA binding site [nucleotide binding]; other site
718252002821	Domain of unknown function (DUF955); Region: DUF955; cl01076
718252002822	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252002823	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252002824	catalytic residues [active]
718252002825	catalytic nucleophile [active]
718252002826	Recombinase; Region: Recombinase; pfam07508
718252002827	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252002828	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252002829	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252002830	catalytic residues [active]
718252002831	catalytic nucleophile [active]
718252002832	Recombinase; Region: Recombinase; pfam07508
718252002833	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252002834	Resolvase, N terminal domain; Region: Resolvase; smart00857
718252002835	Helix-turn-helix domain; Region: HTH_17; cl17695
718252002836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252002837	Walker A motif; other site
718252002838	ATP binding site [chemical binding]; other site
718252002839	Walker B motif; other site
718252002840	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
718252002841	GTP-binding protein YchF; Reviewed; Region: PRK09601
718252002842	YchF GTPase; Region: YchF; cd01900
718252002843	G1 box; other site
718252002844	GTP/Mg2+ binding site [chemical binding]; other site
718252002845	Switch I region; other site
718252002846	G2 box; other site
718252002847	Switch II region; other site
718252002848	G3 box; other site
718252002849	G4 box; other site
718252002850	G5 box; other site
718252002851	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
718252002852	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
718252002853	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718252002854	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718252002855	metal binding site [ion binding]; metal-binding site
718252002856	active site
718252002857	I-site; other site
718252002858	4-alpha-glucanotransferase; Provisional; Region: PRK14508
718252002859	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
718252002860	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
718252002861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252002862	S-adenosylmethionine binding site [chemical binding]; other site
718252002863	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718252002864	active site
718252002865	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
718252002866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718252002867	NAD(P) binding site [chemical binding]; other site
718252002868	active site
718252002869	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
718252002870	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
718252002871	NADP binding site [chemical binding]; other site
718252002872	homodimer interface [polypeptide binding]; other site
718252002873	active site
718252002874	hypothetical protein; Provisional; Region: PRK09273
718252002875	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
718252002876	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
718252002877	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
718252002878	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
718252002879	Cl- selectivity filter; other site
718252002880	Cl- binding residues [ion binding]; other site
718252002881	pore gating glutamate residue; other site
718252002882	dimer interface [polypeptide binding]; other site
718252002883	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
718252002884	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
718252002885	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
718252002886	active site
718252002887	dimer interface [polypeptide binding]; other site
718252002888	motif 1; other site
718252002889	motif 2; other site
718252002890	motif 3; other site
718252002891	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
718252002892	anticodon binding site; other site
718252002893	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
718252002894	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
718252002895	active site
718252002896	HIGH motif; other site
718252002897	dimer interface [polypeptide binding]; other site
718252002898	KMSKS motif; other site
718252002899	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
718252002900	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
718252002901	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
718252002902	active site
718252002903	substrate-binding site [chemical binding]; other site
718252002904	metal-binding site [ion binding]
718252002905	ATP binding site [chemical binding]; other site
718252002906	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252002907	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718252002908	Walker A/P-loop; other site
718252002909	ATP binding site [chemical binding]; other site
718252002910	Q-loop/lid; other site
718252002911	ABC transporter signature motif; other site
718252002912	Walker B; other site
718252002913	D-loop; other site
718252002914	H-loop/switch region; other site
718252002915	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
718252002916	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718252002917	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718252002918	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718252002919	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718252002920	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
718252002921	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718252002922	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718252002923	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
718252002924	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
718252002925	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
718252002926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252002927	active site
718252002928	phosphorylation site [posttranslational modification]
718252002929	intermolecular recognition site; other site
718252002930	dimerization interface [polypeptide binding]; other site
718252002931	LytTr DNA-binding domain; Region: LytTR; pfam04397
718252002932	S-layer homology domain; Region: SLH; pfam00395
718252002933	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718252002934	FtsX-like permease family; Region: FtsX; pfam02687
718252002935	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718252002936	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718252002937	Walker A/P-loop; other site
718252002938	ATP binding site [chemical binding]; other site
718252002939	Q-loop/lid; other site
718252002940	ABC transporter signature motif; other site
718252002941	Walker B; other site
718252002942	D-loop; other site
718252002943	H-loop/switch region; other site
718252002944	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
718252002945	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
718252002946	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718252002947	HlyD family secretion protein; Region: HlyD_3; pfam13437
718252002948	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
718252002949	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252002950	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252002951	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252002952	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252002953	non-specific DNA binding site [nucleotide binding]; other site
718252002954	salt bridge; other site
718252002955	sequence-specific DNA binding site [nucleotide binding]; other site
718252002956	Helix-turn-helix domain; Region: HTH_17; cl17695
718252002957	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252002958	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252002959	active site
718252002960	DNA binding site [nucleotide binding]
718252002961	Int/Topo IB signature motif; other site
718252002962	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
718252002963	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718252002964	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718252002965	nucleotide binding site [chemical binding]; other site
718252002966	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
718252002967	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
718252002968	inhibitor binding site; inhibition site
718252002969	catalytic Zn binding site [ion binding]; other site
718252002970	structural Zn binding site [ion binding]; other site
718252002971	NADP binding site [chemical binding]; other site
718252002972	tetramer interface [polypeptide binding]; other site
718252002973	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
718252002974	active site
718252002975	metal binding site [ion binding]; metal-binding site
718252002976	MFS/sugar transport protein; Region: MFS_2; pfam13347
718252002977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718252002978	putative substrate translocation pore; other site
718252002979	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718252002980	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
718252002981	putative substrate binding site [chemical binding]; other site
718252002982	putative ATP binding site [chemical binding]; other site
718252002983	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
718252002984	regulatory protein interface [polypeptide binding]; other site
718252002985	regulatory phosphorylation site [posttranslational modification]; other site
718252002986	D5 N terminal like; Region: D5_N; cl07360
718252002987	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
718252002988	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252002989	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252002990	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252002991	active site
718252002992	DNA binding site [nucleotide binding]
718252002993	Int/Topo IB signature motif; other site
718252002994	Transposase; Region: DEDD_Tnp_IS110; pfam01548
718252002995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
718252002996	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
718252002997	Helix-turn-helix domain; Region: HTH_36; pfam13730
718252002998	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252002999	Protein of unknown function (DUF3848); Region: DUF3848; pfam12959
718252003000	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
718252003001	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
718252003002	Divergent AAA domain; Region: AAA_4; pfam04326
718252003003	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
718252003004	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252003005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
718252003006	sequence-specific DNA binding site [nucleotide binding]; other site
718252003007	salt bridge; other site
718252003008	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252003009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252003010	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718252003011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003012	dimer interface [polypeptide binding]; other site
718252003013	conserved gate region; other site
718252003014	putative PBP binding loops; other site
718252003015	ABC-ATPase subunit interface; other site
718252003016	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
718252003017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003018	dimer interface [polypeptide binding]; other site
718252003019	conserved gate region; other site
718252003020	putative PBP binding loops; other site
718252003021	ABC-ATPase subunit interface; other site
718252003022	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
718252003023	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
718252003024	substrate binding site [chemical binding]; other site
718252003025	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252003026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252003027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252003028	Walker A/P-loop; other site
718252003029	ATP binding site [chemical binding]; other site
718252003030	Q-loop/lid; other site
718252003031	ABC transporter signature motif; other site
718252003032	Walker B; other site
718252003033	D-loop; other site
718252003034	H-loop/switch region; other site
718252003035	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252003036	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252003037	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252003038	Walker A/P-loop; other site
718252003039	ATP binding site [chemical binding]; other site
718252003040	Q-loop/lid; other site
718252003041	ABC transporter signature motif; other site
718252003042	Walker B; other site
718252003043	D-loop; other site
718252003044	H-loop/switch region; other site
718252003045	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
718252003046	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
718252003047	Helix-turn-helix domain; Region: HTH_16; pfam12645
718252003048	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252003049	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
718252003050	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252003051	active site
718252003052	DNA binding site [nucleotide binding]
718252003053	Int/Topo IB signature motif; other site
718252003054	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718252003055	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718252003056	glycogen branching enzyme; Provisional; Region: PRK12313
718252003057	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
718252003058	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
718252003059	active site
718252003060	catalytic site [active]
718252003061	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
718252003062	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
718252003063	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
718252003064	ligand binding site; other site
718252003065	oligomer interface; other site
718252003066	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
718252003067	dimer interface [polypeptide binding]; other site
718252003068	N-terminal domain interface [polypeptide binding]; other site
718252003069	sulfate 1 binding site; other site
718252003070	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
718252003071	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
718252003072	ligand binding site; other site
718252003073	oligomer interface; other site
718252003074	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
718252003075	dimer interface [polypeptide binding]; other site
718252003076	N-terminal domain interface [polypeptide binding]; other site
718252003077	sulfate 1 binding site; other site
718252003078	glycogen synthase; Provisional; Region: glgA; PRK00654
718252003079	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
718252003080	ADP-binding pocket [chemical binding]; other site
718252003081	homodimer interface [polypeptide binding]; other site
718252003082	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
718252003083	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
718252003084	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
718252003085	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
718252003086	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
718252003087	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
718252003088	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
718252003089	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
718252003090	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
718252003091	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718252003092	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
718252003093	beta subunit interaction interface [polypeptide binding]; other site
718252003094	Walker A motif; other site
718252003095	ATP binding site [chemical binding]; other site
718252003096	Walker B motif; other site
718252003097	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718252003098	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
718252003099	core domain interface [polypeptide binding]; other site
718252003100	delta subunit interface [polypeptide binding]; other site
718252003101	epsilon subunit interface [polypeptide binding]; other site
718252003102	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
718252003103	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718252003104	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
718252003105	alpha subunit interaction interface [polypeptide binding]; other site
718252003106	Walker A motif; other site
718252003107	ATP binding site [chemical binding]; other site
718252003108	Walker B motif; other site
718252003109	inhibitor binding site; inhibition site
718252003110	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718252003111	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
718252003112	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
718252003113	gamma subunit interface [polypeptide binding]; other site
718252003114	epsilon subunit interface [polypeptide binding]; other site
718252003115	LBP interface [polypeptide binding]; other site
718252003116	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
718252003117	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
718252003118	ATP-binding site [chemical binding]; other site
718252003119	Sugar specificity; other site
718252003120	Pyrimidine base specificity; other site
718252003121	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
718252003122	putative active site [active]
718252003123	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
718252003124	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
718252003125	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
718252003126	putative active site [active]
718252003127	catalytic site [active]
718252003128	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
718252003129	putative active site [active]
718252003130	catalytic site [active]
718252003131	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718252003132	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718252003133	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
718252003134	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
718252003135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718252003136	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
718252003137	Predicted nucleotidyltransferase [General function prediction only]; Region: COG1323
718252003138	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
718252003139	propionate/acetate kinase; Provisional; Region: PRK12379
718252003140	Probable zinc-binding domain; Region: zf-trcl; pfam13451
718252003141	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
718252003142	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
718252003143	Uncharacterized conserved protein [Function unknown]; Region: COG0327
718252003144	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
718252003145	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
718252003146	Domain of unknown function (DUF814); Region: DUF814; pfam05670
718252003147	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252003148	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252003149	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252003150	DNA binding residues [nucleotide binding]
718252003151	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
718252003152	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
718252003153	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
718252003154	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
718252003155	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
718252003156	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
718252003157	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
718252003158	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
718252003159	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
718252003160	protein-rRNA interface [nucleotide binding]; other site
718252003161	putative translocon binding site; other site
718252003162	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
718252003163	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
718252003164	G-X-X-G motif; other site
718252003165	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
718252003166	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
718252003167	23S rRNA interface [nucleotide binding]; other site
718252003168	5S rRNA interface [nucleotide binding]; other site
718252003169	putative antibiotic binding site [chemical binding]; other site
718252003170	L25 interface [polypeptide binding]; other site
718252003171	L27 interface [polypeptide binding]; other site
718252003172	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
718252003173	23S rRNA interface [nucleotide binding]; other site
718252003174	putative translocon interaction site; other site
718252003175	signal recognition particle (SRP54) interaction site; other site
718252003176	L23 interface [polypeptide binding]; other site
718252003177	trigger factor interaction site; other site
718252003178	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
718252003179	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
718252003180	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
718252003181	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
718252003182	RNA binding site [nucleotide binding]; other site
718252003183	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
718252003184	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
718252003185	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
718252003186	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
718252003187	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
718252003188	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
718252003189	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
718252003190	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
718252003191	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
718252003192	5S rRNA interface [nucleotide binding]; other site
718252003193	L27 interface [polypeptide binding]; other site
718252003194	23S rRNA interface [nucleotide binding]; other site
718252003195	L5 interface [polypeptide binding]; other site
718252003196	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
718252003197	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
718252003198	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
718252003199	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
718252003200	23S rRNA binding site [nucleotide binding]; other site
718252003201	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
718252003202	adenylate kinase; Reviewed; Region: adk; PRK00279
718252003203	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
718252003204	AMP-binding site [chemical binding]; other site
718252003205	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
718252003206	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
718252003207	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
718252003208	30S ribosomal protein S13; Region: bact_S13; TIGR03631
718252003209	30S ribosomal protein S11; Validated; Region: PRK05309
718252003210	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
718252003211	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
718252003212	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252003213	RNA binding surface [nucleotide binding]; other site
718252003214	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
718252003215	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
718252003216	alphaNTD - beta interaction site [polypeptide binding]; other site
718252003217	alphaNTD homodimer interface [polypeptide binding]; other site
718252003218	alphaNTD - beta' interaction site [polypeptide binding]; other site
718252003219	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
718252003220	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
718252003221	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252003222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252003223	active site
718252003224	phosphorylation site [posttranslational modification]
718252003225	intermolecular recognition site; other site
718252003226	dimerization interface [polypeptide binding]; other site
718252003227	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252003228	DNA binding site [nucleotide binding]
718252003229	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252003230	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252003231	dimerization interface [polypeptide binding]; other site
718252003232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252003233	dimer interface [polypeptide binding]; other site
718252003234	phosphorylation site [posttranslational modification]
718252003235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252003236	ATP binding site [chemical binding]; other site
718252003237	Mg2+ binding site [ion binding]; other site
718252003238	G-X-G motif; other site
718252003239	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
718252003240	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
718252003241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252003242	S-adenosylmethionine binding site [chemical binding]; other site
718252003243	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
718252003244	recombinase A; Provisional; Region: recA; PRK09354
718252003245	hexamer interface [polypeptide binding]; other site
718252003246	Walker A motif; other site
718252003247	ATP binding site [chemical binding]; other site
718252003248	Walker B motif; other site
718252003249	recombination regulator RecX; Reviewed; Region: recX; PRK00117
718252003250	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
718252003251	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718252003252	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252003253	FeS/SAM binding site; other site
718252003254	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
718252003255	asparagine synthetase AsnA; Provisional; Region: PRK05425
718252003256	motif 1; other site
718252003257	dimer interface [polypeptide binding]; other site
718252003258	active site
718252003259	motif 2; other site
718252003260	motif 3; other site
718252003261	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718252003262	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
718252003263	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
718252003264	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
718252003265	active site
718252003266	HIGH motif; other site
718252003267	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
718252003268	KMSKS motif; other site
718252003269	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
718252003270	tRNA binding surface [nucleotide binding]; other site
718252003271	anticodon binding site; other site
718252003272	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718252003273	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718252003274	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718252003275	metal binding site [ion binding]; metal-binding site
718252003276	active site
718252003277	I-site; other site
718252003278	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718252003279	LrgB-like family; Region: LrgB; pfam04172
718252003280	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718252003281	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
718252003282	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718252003283	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718252003284	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
718252003285	nudix motif; other site
718252003286	SnoaL-like domain; Region: SnoaL_2; pfam12680
718252003287	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
718252003288	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
718252003289	active site
718252003290	Zn binding site [ion binding]; other site
718252003291	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
718252003292	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718252003293	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
718252003294	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718252003295	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718252003296	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252003297	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718252003298	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
718252003299	active site
718252003300	putative catalytic site [active]
718252003301	DNA binding site [nucleotide binding]
718252003302	putative phosphate binding site [ion binding]; other site
718252003303	metal binding site A [ion binding]; metal-binding site
718252003304	AP binding site [nucleotide binding]; other site
718252003305	metal binding site B [ion binding]; metal-binding site
718252003306	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
718252003307	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
718252003308	dipeptidase PepV; Reviewed; Region: PRK07318
718252003309	active site
718252003310	metal binding site [ion binding]; metal-binding site
718252003311	serine O-acetyltransferase; Region: cysE; TIGR01172
718252003312	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
718252003313	trimer interface [polypeptide binding]; other site
718252003314	active site
718252003315	substrate binding site [chemical binding]; other site
718252003316	CoA binding site [chemical binding]; other site
718252003317	dihydroorotase; Validated; Region: pyrC; PRK09357
718252003318	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718252003319	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
718252003320	active site
718252003321	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
718252003322	active site
718252003323	dimer interface [polypeptide binding]; other site
718252003324	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
718252003325	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
718252003326	FAD binding pocket [chemical binding]; other site
718252003327	FAD binding motif [chemical binding]; other site
718252003328	phosphate binding motif [ion binding]; other site
718252003329	beta-alpha-beta structure motif; other site
718252003330	NAD binding pocket [chemical binding]; other site
718252003331	Iron coordination center [ion binding]; other site
718252003332	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
718252003333	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
718252003334	heterodimer interface [polypeptide binding]; other site
718252003335	active site
718252003336	FMN binding site [chemical binding]; other site
718252003337	homodimer interface [polypeptide binding]; other site
718252003338	substrate binding site [chemical binding]; other site
718252003339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252003340	active site
718252003341	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
718252003342	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
718252003343	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
718252003344	catalytic site [active]
718252003345	subunit interface [polypeptide binding]; other site
718252003346	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
718252003347	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718252003348	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
718252003349	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
718252003350	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718252003351	ATP-grasp domain; Region: ATP-grasp_4; cl17255
718252003352	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
718252003353	IMP binding site; other site
718252003354	dimer interface [polypeptide binding]; other site
718252003355	interdomain contacts; other site
718252003356	partial ornithine binding site; other site
718252003357	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718252003358	IHF dimer interface [polypeptide binding]; other site
718252003359	IHF - DNA interface [nucleotide binding]; other site
718252003360	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718252003361	DEAD-like helicases superfamily; Region: DEXDc; smart00487
718252003362	ATP binding site [chemical binding]; other site
718252003363	Mg++ binding site [ion binding]; other site
718252003364	motif III; other site
718252003365	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252003366	nucleotide binding region [chemical binding]; other site
718252003367	ATP-binding site [chemical binding]; other site
718252003368	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
718252003369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718252003370	ATP binding site [chemical binding]; other site
718252003371	putative Mg++ binding site [ion binding]; other site
718252003372	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
718252003373	SEC-C motif; Region: SEC-C; pfam02810
718252003374	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
718252003375	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
718252003376	metal binding site [ion binding]; metal-binding site
718252003377	dimer interface [polypeptide binding]; other site
718252003378	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718252003379	active site
718252003380	catalytic triad [active]
718252003381	oxyanion hole [active]
718252003382	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
718252003383	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
718252003384	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
718252003385	Ligand Binding Site [chemical binding]; other site
718252003386	competence damage-inducible protein A; Provisional; Region: PRK00549
718252003387	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
718252003388	putative MPT binding site; other site
718252003389	Competence-damaged protein; Region: CinA; pfam02464
718252003390	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
718252003391	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252003392	Walker A/P-loop; other site
718252003393	ATP binding site [chemical binding]; other site
718252003394	Q-loop/lid; other site
718252003395	ABC transporter signature motif; other site
718252003396	Walker B; other site
718252003397	D-loop; other site
718252003398	H-loop/switch region; other site
718252003399	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252003400	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718252003401	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252003402	Walker A/P-loop; other site
718252003403	ATP binding site [chemical binding]; other site
718252003404	Q-loop/lid; other site
718252003405	ABC transporter signature motif; other site
718252003406	Walker B; other site
718252003407	D-loop; other site
718252003408	H-loop/switch region; other site
718252003409	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252003410	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
718252003411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003412	dimer interface [polypeptide binding]; other site
718252003413	conserved gate region; other site
718252003414	putative PBP binding loops; other site
718252003415	ABC-ATPase subunit interface; other site
718252003416	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718252003417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003418	dimer interface [polypeptide binding]; other site
718252003419	conserved gate region; other site
718252003420	putative PBP binding loops; other site
718252003421	ABC-ATPase subunit interface; other site
718252003422	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
718252003423	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
718252003424	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718252003425	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718252003426	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718252003427	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718252003428	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
718252003429	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
718252003430	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
718252003431	G1 box; other site
718252003432	putative GEF interaction site [polypeptide binding]; other site
718252003433	GTP/Mg2+ binding site [chemical binding]; other site
718252003434	Switch I region; other site
718252003435	G2 box; other site
718252003436	G3 box; other site
718252003437	Switch II region; other site
718252003438	G4 box; other site
718252003439	G5 box; other site
718252003440	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
718252003441	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
718252003442	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
718252003443	YacP-like NYN domain; Region: NYN_YacP; pfam05991
718252003444	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
718252003445	putative substrate binding site [chemical binding]; other site
718252003446	putative ATP binding site [chemical binding]; other site
718252003447	NAD-dependent deacetylase; Provisional; Region: PRK00481
718252003448	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
718252003449	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003450	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
718252003451	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003452	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003453	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
718252003454	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003455	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003456	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
718252003457	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003458	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718252003459	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
718252003460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252003461	dimer interface [polypeptide binding]; other site
718252003462	phosphorylation site [posttranslational modification]
718252003463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252003464	ATP binding site [chemical binding]; other site
718252003465	Mg2+ binding site [ion binding]; other site
718252003466	G-X-G motif; other site
718252003467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252003468	Response regulator receiver domain; Region: Response_reg; pfam00072
718252003469	active site
718252003470	phosphorylation site [posttranslational modification]
718252003471	intermolecular recognition site; other site
718252003472	dimerization interface [polypeptide binding]; other site
718252003473	Response regulator receiver domain; Region: Response_reg; pfam00072
718252003474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252003475	active site
718252003476	phosphorylation site [posttranslational modification]
718252003477	intermolecular recognition site; other site
718252003478	dimerization interface [polypeptide binding]; other site
718252003479	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718252003480	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718252003481	substrate binding pocket [chemical binding]; other site
718252003482	membrane-bound complex binding site; other site
718252003483	hinge residues; other site
718252003484	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252003485	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252003486	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252003487	catalytic residues [active]
718252003488	catalytic nucleophile [active]
718252003489	Recombinase; Region: Recombinase; pfam07508
718252003490	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252003491	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
718252003492	active site
718252003493	catalytic residues [active]
718252003494	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
718252003495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718252003496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252003497	homodimer interface [polypeptide binding]; other site
718252003498	catalytic residue [active]
718252003499	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
718252003500	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718252003501	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718252003502	acyl carrier protein; Provisional; Region: acpP; PRK00982
718252003503	prolyl-tRNA synthetase; Provisional; Region: PRK08661
718252003504	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
718252003505	dimer interface [polypeptide binding]; other site
718252003506	motif 1; other site
718252003507	active site
718252003508	motif 2; other site
718252003509	motif 3; other site
718252003510	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
718252003511	anticodon binding site; other site
718252003512	zinc-binding site [ion binding]; other site
718252003513	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
718252003514	MgtE intracellular N domain; Region: MgtE_N; pfam03448
718252003515	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
718252003516	Divalent cation transporter; Region: MgtE; pfam01769
718252003517	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252003518	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252003519	non-specific DNA binding site [nucleotide binding]; other site
718252003520	salt bridge; other site
718252003521	sequence-specific DNA binding site [nucleotide binding]; other site
718252003522	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
718252003523	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
718252003524	non-heme iron binding site [ion binding]; other site
718252003525	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718252003526	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252003527	Coenzyme A binding pocket [chemical binding]; other site
718252003528	Domain of unknown function (DUF386); Region: DUF386; cl01047
718252003529	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
718252003530	HflK protein; Region: hflK; TIGR01933
718252003531	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
718252003532	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
718252003533	active site
718252003534	homodimer interface [polypeptide binding]; other site
718252003535	catalytic site [active]
718252003536	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
718252003537	homodimer interface [polypeptide binding]; other site
718252003538	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
718252003539	active site pocket [active]
718252003540	Protein of unknown function (DUF972); Region: DUF972; pfam06156
718252003541	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718252003542	Peptidase family U32; Region: Peptidase_U32; pfam01136
718252003543	Collagenase; Region: DUF3656; pfam12392
718252003544	Peptidase family U32; Region: Peptidase_U32; cl03113
718252003545	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
718252003546	trimer interface [polypeptide binding]; other site
718252003547	active site
718252003548	Maf-like protein; Region: Maf; pfam02545
718252003549	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
718252003550	active site
718252003551	dimer interface [polypeptide binding]; other site
718252003552	rod shape-determining protein MreB; Provisional; Region: PRK13927
718252003553	MreB and similar proteins; Region: MreB_like; cd10225
718252003554	nucleotide binding site [chemical binding]; other site
718252003555	Mg binding site [ion binding]; other site
718252003556	putative protofilament interaction site [polypeptide binding]; other site
718252003557	RodZ interaction site [polypeptide binding]; other site
718252003558	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718252003559	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718252003560	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
718252003561	active site
718252003562	dimer interfaces [polypeptide binding]; other site
718252003563	catalytic residues [active]
718252003564	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
718252003565	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
718252003566	RNA/DNA hybrid binding site [nucleotide binding]; other site
718252003567	active site
718252003568	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
718252003569	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718252003570	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
718252003571	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
718252003572	DHH family; Region: DHH; pfam01368
718252003573	DHHA1 domain; Region: DHHA1; pfam02272
718252003574	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
718252003575	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718252003576	UDP-galactopyranose mutase; Region: GLF; pfam03275
718252003577	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
718252003578	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
718252003579	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
718252003580	replicative DNA helicase; Region: DnaB; TIGR00665
718252003581	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
718252003582	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
718252003583	Walker A motif; other site
718252003584	ATP binding site [chemical binding]; other site
718252003585	Walker B motif; other site
718252003586	DNA binding loops [nucleotide binding]
718252003587	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
718252003588	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
718252003589	Ligand Binding Site [chemical binding]; other site
718252003590	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
718252003591	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252003592	active site
718252003593	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
718252003594	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
718252003595	histidyl-tRNA synthetase; Region: hisS; TIGR00442
718252003596	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
718252003597	dimer interface [polypeptide binding]; other site
718252003598	motif 1; other site
718252003599	active site
718252003600	motif 2; other site
718252003601	motif 3; other site
718252003602	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
718252003603	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
718252003604	GGGtGRT protein; Region: GGGtGRT; pfam14057
718252003605	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
718252003606	L-aspartate oxidase; Provisional; Region: PRK06175
718252003607	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
718252003608	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
718252003609	E3 interaction surface; other site
718252003610	lipoyl attachment site [posttranslational modification]; other site
718252003611	HlyD family secretion protein; Region: HlyD_3; pfam13437
718252003612	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718252003613	carboxyltransferase (CT) interaction site; other site
718252003614	biotinylation site [posttranslational modification]; other site
718252003615	HlyD family secretion protein; Region: HlyD_3; pfam13437
718252003616	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718252003617	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718252003618	Walker A/P-loop; other site
718252003619	ATP binding site [chemical binding]; other site
718252003620	Q-loop/lid; other site
718252003621	ABC transporter signature motif; other site
718252003622	Walker B; other site
718252003623	D-loop; other site
718252003624	H-loop/switch region; other site
718252003625	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718252003626	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718252003627	FtsX-like permease family; Region: FtsX; pfam02687
718252003628	S-layer homology domain; Region: SLH; pfam00395
718252003629	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
718252003630	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252003631	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252003632	non-specific DNA binding site [nucleotide binding]; other site
718252003633	salt bridge; other site
718252003634	sequence-specific DNA binding site [nucleotide binding]; other site
718252003635	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252003636	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252003637	non-specific DNA binding site [nucleotide binding]; other site
718252003638	salt bridge; other site
718252003639	sequence-specific DNA binding site [nucleotide binding]; other site
718252003640	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252003641	Zn2+ binding site [ion binding]; other site
718252003642	Mg2+ binding site [ion binding]; other site
718252003643	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718252003644	DNA binding site [nucleotide binding]
718252003645	substrate interaction site [chemical binding]; other site
718252003646	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718252003647	3D domain; Region: 3D; cl01439
718252003648	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
718252003649	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
718252003650	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
718252003651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252003652	S-adenosylmethionine binding site [chemical binding]; other site
718252003653	Methyltransferase domain; Region: Methyltransf_27; pfam13708
718252003654	Uncharacterized conserved protein [Function unknown]; Region: COG5484
718252003655	Phage terminase small subunit; Region: Phage_terminase; pfam10668
718252003656	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
718252003657	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
718252003658	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
718252003659	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
718252003660	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
718252003661	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
718252003662	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
718252003663	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
718252003664	Phage tail tube protein FII; Region: Phage_tube; cl01390
718252003665	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
718252003666	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
718252003667	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
718252003668	baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596
718252003669	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
718252003670	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
718252003671	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
718252003672	flagellin; Validated; Region: PRK08026
718252003673	Peptidase M15; Region: Peptidase_M15_3; cl01194
718252003674	Domain of unknown function (DUF955); Region: DUF955; cl01076
718252003675	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
718252003676	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
718252003677	HsdM N-terminal domain; Region: HsdM_N; pfam12161
718252003678	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
718252003679	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718252003680	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
718252003681	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
718252003682	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
718252003683	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252003684	ATP binding site [chemical binding]; other site
718252003685	putative Mg++ binding site [ion binding]; other site
718252003686	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
718252003687	Caspase domain; Region: Peptidase_C14; pfam00656
718252003688	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252003689	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252003690	catalytic residues [active]
718252003691	catalytic nucleophile [active]
718252003692	Recombinase; Region: Recombinase; pfam07508
718252003693	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252003694	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
718252003695	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252003696	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252003697	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252003698	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
718252003699	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252003700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003701	dimer interface [polypeptide binding]; other site
718252003702	conserved gate region; other site
718252003703	putative PBP binding loops; other site
718252003704	ABC-ATPase subunit interface; other site
718252003705	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252003706	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718252003707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252003708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252003709	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
718252003710	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252003711	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718252003712	Walker A/P-loop; other site
718252003713	ATP binding site [chemical binding]; other site
718252003714	Q-loop/lid; other site
718252003715	ABC transporter signature motif; other site
718252003716	Walker B; other site
718252003717	D-loop; other site
718252003718	H-loop/switch region; other site
718252003719	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718252003720	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
718252003721	Predicted transcriptional regulators [Transcription]; Region: COG1695
718252003722	Transcriptional regulator PadR-like family; Region: PadR; cl17335
718252003723	MFS/sugar transport protein; Region: MFS_2; pfam13347
718252003724	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718252003725	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
718252003726	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
718252003727	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718252003728	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718252003729	Walker A/P-loop; other site
718252003730	ATP binding site [chemical binding]; other site
718252003731	Q-loop/lid; other site
718252003732	ABC transporter signature motif; other site
718252003733	Walker B; other site
718252003734	D-loop; other site
718252003735	H-loop/switch region; other site
718252003736	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252003737	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252003738	DNA binding residues [nucleotide binding]
718252003739	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718252003740	Beta-lactamase; Region: Beta-lactamase; pfam00144
718252003741	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
718252003742	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
718252003743	DNA binding residues [nucleotide binding]
718252003744	drug binding residues [chemical binding]; other site
718252003745	dimer interface [polypeptide binding]; other site
718252003746	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
718252003747	PemK-like protein; Region: PemK; pfam02452
718252003748	CAT RNA binding domain; Region: CAT_RBD; smart01061
718252003749	PRD domain; Region: PRD; pfam00874
718252003750	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718252003751	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
718252003752	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718252003753	active site turn [active]
718252003754	phosphorylation site [posttranslational modification]
718252003755	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
718252003756	HPr interaction site; other site
718252003757	glycerol kinase (GK) interaction site [polypeptide binding]; other site
718252003758	active site
718252003759	phosphorylation site [posttranslational modification]
718252003760	Chromate transporter; Region: Chromate_transp; pfam02417
718252003761	Chromate transporter; Region: Chromate_transp; pfam02417
718252003762	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
718252003763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252003764	FeS/SAM binding site; other site
718252003765	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718252003766	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252003767	DNA-binding site [nucleotide binding]; DNA binding site
718252003768	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718252003769	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718252003770	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718252003771	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
718252003772	Sulfatase; Region: Sulfatase; cl17466
718252003773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
718252003774	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
718252003775	DNA polymerase IV; Reviewed; Region: PRK03103
718252003776	Y-family of DNA polymerases; Region: PolY; cl12025
718252003777	active site
718252003778	DNA binding site [nucleotide binding]
718252003779	YolD-like protein; Region: YolD; pfam08863
718252003780	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
718252003781	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
718252003782	non-heme iron binding site [ion binding]; other site
718252003783	dimer interface [polypeptide binding]; other site
718252003784	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
718252003785	non-heme iron binding site [ion binding]; other site
718252003786	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
718252003787	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718252003788	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
718252003789	putative dimer interface [polypeptide binding]; other site
718252003790	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718252003791	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718252003792	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
718252003793	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718252003794	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
718252003795	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
718252003796	Isochorismatase family; Region: Isochorismatase; pfam00857
718252003797	catalytic triad [active]
718252003798	conserved cis-peptide bond; other site
718252003799	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252003800	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
718252003801	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
718252003802	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718252003803	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252003804	ABC transporter signature motif; other site
718252003805	Walker B; other site
718252003806	D-loop; other site
718252003807	Low molecular weight phosphatase family; Region: LMWPc; cl00105
718252003808	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
718252003809	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
718252003810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252003811	S-adenosylmethionine binding site [chemical binding]; other site
718252003812	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
718252003813	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
718252003814	Regulator protein PHA-1; Region: PHA-1; pfam06542
718252003815	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
718252003816	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718252003817	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
718252003818	transmembrane helices; other site
718252003819	Membrane transport protein; Region: Mem_trans; cl09117
718252003820	Integrase core domain; Region: rve; pfam00665
718252003821	Integrase core domain; Region: rve_2; pfam13333
718252003822	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252003823	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252003824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252003825	Walker A/P-loop; other site
718252003826	ATP binding site [chemical binding]; other site
718252003827	Q-loop/lid; other site
718252003828	ABC transporter signature motif; other site
718252003829	Walker B; other site
718252003830	D-loop; other site
718252003831	H-loop/switch region; other site
718252003832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718252003833	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718252003834	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
718252003835	EDD domain protein, DegV family; Region: DegV; TIGR00762
718252003836	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718252003837	QueT transporter; Region: QueT; pfam06177
718252003838	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252003839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252003840	non-specific DNA binding site [nucleotide binding]; other site
718252003841	salt bridge; other site
718252003842	sequence-specific DNA binding site [nucleotide binding]; other site
718252003843	Flagellin N-methylase; Region: FliB; cl00497
718252003844	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
718252003845	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
718252003846	zinc binding site [ion binding]; other site
718252003847	putative ligand binding site [chemical binding]; other site
718252003848	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718252003849	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
718252003850	TM-ABC transporter signature motif; other site
718252003851	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
718252003852	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252003853	Walker A/P-loop; other site
718252003854	ATP binding site [chemical binding]; other site
718252003855	Q-loop/lid; other site
718252003856	ABC transporter signature motif; other site
718252003857	Walker B; other site
718252003858	D-loop; other site
718252003859	H-loop/switch region; other site
718252003860	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
718252003861	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
718252003862	dimer interface [polypeptide binding]; other site
718252003863	active site
718252003864	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718252003865	catalytic residues [active]
718252003866	substrate binding site [chemical binding]; other site
718252003867	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
718252003868	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
718252003869	NAD(P) binding pocket [chemical binding]; other site
718252003870	agmatinase; Region: agmatinase; TIGR01230
718252003871	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
718252003872	putative active site [active]
718252003873	Mn binding site [ion binding]; other site
718252003874	spermidine synthase; Provisional; Region: PRK00811
718252003875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252003876	S-adenosylmethionine binding site [chemical binding]; other site
718252003877	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
718252003878	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718252003879	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252003880	catalytic residue [active]
718252003881	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718252003882	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718252003883	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718252003884	substrate binding site [chemical binding]; other site
718252003885	ATP binding site [chemical binding]; other site
718252003886	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
718252003887	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
718252003888	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
718252003889	active site
718252003890	metal binding site [ion binding]; metal-binding site
718252003891	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
718252003892	glycerol kinase; Provisional; Region: glpK; PRK00047
718252003893	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
718252003894	N- and C-terminal domain interface [polypeptide binding]; other site
718252003895	active site
718252003896	MgATP binding site [chemical binding]; other site
718252003897	catalytic site [active]
718252003898	metal binding site [ion binding]; metal-binding site
718252003899	glycerol binding site [chemical binding]; other site
718252003900	homotetramer interface [polypeptide binding]; other site
718252003901	homodimer interface [polypeptide binding]; other site
718252003902	FBP binding site [chemical binding]; other site
718252003903	protein IIAGlc interface [polypeptide binding]; other site
718252003904	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252003905	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252003906	catalytic residues [active]
718252003907	catalytic nucleophile [active]
718252003908	Recombinase; Region: Recombinase; pfam07508
718252003909	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252003910	Virulence protein [General function prediction only]; Region: COG3943
718252003911	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
718252003912	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
718252003913	D5 N terminal like; Region: D5_N; smart00885
718252003914	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
718252003915	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
718252003916	CHC2 zinc finger; Region: zf-CHC2; cl17510
718252003917	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252003918	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252003919	non-specific DNA binding site [nucleotide binding]; other site
718252003920	salt bridge; other site
718252003921	sequence-specific DNA binding site [nucleotide binding]; other site
718252003922	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
718252003923	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
718252003924	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
718252003925	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252003926	ATP binding site [chemical binding]; other site
718252003927	putative Mg++ binding site [ion binding]; other site
718252003928	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252003929	nucleotide binding region [chemical binding]; other site
718252003930	ATP-binding site [chemical binding]; other site
718252003931	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
718252003932	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
718252003933	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718252003934	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718252003935	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
718252003936	HsdM N-terminal domain; Region: HsdM_N; pfam12161
718252003937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
718252003938	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
718252003939	non-specific DNA binding site [nucleotide binding]; other site
718252003940	salt bridge; other site
718252003941	sequence-specific DNA binding site [nucleotide binding]; other site
718252003942	TRAM domain; Region: TRAM; pfam01938
718252003943	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
718252003944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252003945	S-adenosylmethionine binding site [chemical binding]; other site
718252003946	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718252003947	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252003948	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252003949	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252003950	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
718252003951	galactokinase; Provisional; Region: PRK00555
718252003952	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718252003953	4-alpha-glucanotransferase; Provisional; Region: PRK14508
718252003954	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252003955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003956	dimer interface [polypeptide binding]; other site
718252003957	conserved gate region; other site
718252003958	putative PBP binding loops; other site
718252003959	ABC-ATPase subunit interface; other site
718252003960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252003961	dimer interface [polypeptide binding]; other site
718252003962	conserved gate region; other site
718252003963	putative PBP binding loops; other site
718252003964	ABC-ATPase subunit interface; other site
718252003965	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718252003966	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718252003967	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718252003968	DNA binding site [nucleotide binding]
718252003969	domain linker motif; other site
718252003970	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
718252003971	ligand binding site [chemical binding]; other site
718252003972	dimerization interface [polypeptide binding]; other site
718252003973	FtsX-like permease family; Region: FtsX; pfam02687
718252003974	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718252003975	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718252003976	Walker A/P-loop; other site
718252003977	ATP binding site [chemical binding]; other site
718252003978	Q-loop/lid; other site
718252003979	ABC transporter signature motif; other site
718252003980	Walker B; other site
718252003981	D-loop; other site
718252003982	H-loop/switch region; other site
718252003983	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
718252003984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
718252003985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
718252003986	hypothetical protein; Provisional; Region: PRK13663
718252003987	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
718252003988	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
718252003989	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718252003990	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
718252003991	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
718252003992	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
718252003993	galactokinase; Provisional; Region: PRK05101
718252003994	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
718252003995	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718252003996	heat shock protein 90; Provisional; Region: PRK05218
718252003997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252003998	ATP binding site [chemical binding]; other site
718252003999	Mg2+ binding site [ion binding]; other site
718252004000	G-X-G motif; other site
718252004001	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
718252004002	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718252004003	HD domain; Region: HD; pfam01966
718252004004	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
718252004005	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252004006	Coenzyme A binding pocket [chemical binding]; other site
718252004007	histidinol-phosphatase; Provisional; Region: PRK07328
718252004008	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
718252004009	active site
718252004010	dimer interface [polypeptide binding]; other site
718252004011	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
718252004012	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718252004013	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
718252004014	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
718252004015	RmuC family; Region: RmuC; pfam02646
718252004016	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
718252004017	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718252004018	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718252004019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718252004020	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
718252004021	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
718252004022	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
718252004023	dimer interface [polypeptide binding]; other site
718252004024	motif 1; other site
718252004025	active site
718252004026	motif 2; other site
718252004027	motif 3; other site
718252004028	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
718252004029	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
718252004030	putative tRNA-binding site [nucleotide binding]; other site
718252004031	B3/4 domain; Region: B3_4; pfam03483
718252004032	tRNA synthetase B5 domain; Region: B5; pfam03484
718252004033	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
718252004034	dimer interface [polypeptide binding]; other site
718252004035	motif 1; other site
718252004036	motif 3; other site
718252004037	motif 2; other site
718252004038	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
718252004039	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
718252004040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252004041	Zn2+ binding site [ion binding]; other site
718252004042	Mg2+ binding site [ion binding]; other site
718252004043	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
718252004044	DNA primase; Validated; Region: dnaG; PRK05667
718252004045	CHC2 zinc finger; Region: zf-CHC2; pfam01807
718252004046	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
718252004047	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
718252004048	active site
718252004049	metal binding site [ion binding]; metal-binding site
718252004050	interdomain interaction site; other site
718252004051	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
718252004052	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
718252004053	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
718252004054	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
718252004055	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252004056	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718252004057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252004058	DNA binding residues [nucleotide binding]
718252004059	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
718252004060	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
718252004061	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
718252004062	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
718252004063	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
718252004064	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
718252004065	RPB1 interaction site [polypeptide binding]; other site
718252004066	RPB10 interaction site [polypeptide binding]; other site
718252004067	RPB11 interaction site [polypeptide binding]; other site
718252004068	RPB3 interaction site [polypeptide binding]; other site
718252004069	RPB12 interaction site [polypeptide binding]; other site
718252004070	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
718252004071	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
718252004072	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
718252004073	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
718252004074	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
718252004075	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
718252004076	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
718252004077	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
718252004078	DNA binding site [nucleotide binding]
718252004079	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
718252004080	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
718252004081	S17 interaction site [polypeptide binding]; other site
718252004082	S8 interaction site; other site
718252004083	16S rRNA interaction site [nucleotide binding]; other site
718252004084	streptomycin interaction site [chemical binding]; other site
718252004085	23S rRNA interaction site [nucleotide binding]; other site
718252004086	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
718252004087	30S ribosomal protein S7; Validated; Region: PRK05302
718252004088	elongation factor G; Reviewed; Region: PRK00007
718252004089	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
718252004090	G1 box; other site
718252004091	putative GEF interaction site [polypeptide binding]; other site
718252004092	GTP/Mg2+ binding site [chemical binding]; other site
718252004093	Switch I region; other site
718252004094	G2 box; other site
718252004095	G3 box; other site
718252004096	Switch II region; other site
718252004097	G4 box; other site
718252004098	G5 box; other site
718252004099	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
718252004100	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
718252004101	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
718252004102	elongation factor Tu; Reviewed; Region: PRK00049
718252004103	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
718252004104	G1 box; other site
718252004105	GEF interaction site [polypeptide binding]; other site
718252004106	GTP/Mg2+ binding site [chemical binding]; other site
718252004107	Switch I region; other site
718252004108	G2 box; other site
718252004109	G3 box; other site
718252004110	Switch II region; other site
718252004111	G4 box; other site
718252004112	G5 box; other site
718252004113	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
718252004114	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
718252004115	Antibiotic Binding Site [chemical binding]; other site
718252004116	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
718252004117	Cupin domain; Region: Cupin_2; cl17218
718252004118	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
718252004119	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
718252004120	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
718252004121	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
718252004122	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
718252004123	Na2 binding site [ion binding]; other site
718252004124	putative substrate binding site 1 [chemical binding]; other site
718252004125	Na binding site 1 [ion binding]; other site
718252004126	putative substrate binding site 2 [chemical binding]; other site
718252004127	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
718252004128	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718252004129	substrate binding site [chemical binding]; other site
718252004130	ATP binding site [chemical binding]; other site
718252004131	DNA replication protein DnaC; Validated; Region: PRK06835
718252004132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252004133	Walker A motif; other site
718252004134	ATP binding site [chemical binding]; other site
718252004135	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
718252004136	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
718252004137	TSCPD domain; Region: TSCPD; cl14834
718252004138	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
718252004139	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
718252004140	active site
718252004141	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
718252004142	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252004143	Coenzyme A binding pocket [chemical binding]; other site
718252004144	YoaP-like; Region: YoaP; pfam14268
718252004145	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718252004146	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
718252004147	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
718252004148	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
718252004149	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252004150	DNA binding residues [nucleotide binding]
718252004151	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252004152	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252004153	DNA binding residues [nucleotide binding]
718252004154	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252004155	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252004156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252004157	Walker A/P-loop; other site
718252004158	ATP binding site [chemical binding]; other site
718252004159	Q-loop/lid; other site
718252004160	ABC transporter signature motif; other site
718252004161	Walker B; other site
718252004162	D-loop; other site
718252004163	H-loop/switch region; other site
718252004164	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718252004165	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252004166	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718252004167	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718252004168	Walker A/P-loop; other site
718252004169	ATP binding site [chemical binding]; other site
718252004170	Q-loop/lid; other site
718252004171	ABC transporter signature motif; other site
718252004172	Walker B; other site
718252004173	D-loop; other site
718252004174	H-loop/switch region; other site
718252004175	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718252004176	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
718252004177	Walker A/P-loop; other site
718252004178	ATP binding site [chemical binding]; other site
718252004179	Q-loop/lid; other site
718252004180	ABC transporter signature motif; other site
718252004181	Walker B; other site
718252004182	D-loop; other site
718252004183	H-loop/switch region; other site
718252004184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252004185	non-specific DNA binding site [nucleotide binding]; other site
718252004186	salt bridge; other site
718252004187	sequence-specific DNA binding site [nucleotide binding]; other site
718252004188	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252004189	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
718252004190	putative FMN binding site [chemical binding]; other site
718252004191	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
718252004192	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718252004193	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718252004194	active site
718252004195	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718252004196	active site
718252004197	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
718252004198	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
718252004199	Dimer interface [polypeptide binding]; other site
718252004200	anticodon binding site; other site
718252004201	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718252004202	motif 1; other site
718252004203	dimer interface [polypeptide binding]; other site
718252004204	active site
718252004205	motif 2; other site
718252004206	motif 3; other site
718252004207	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718252004208	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252004209	metal-binding site [ion binding]
718252004210	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718252004211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252004212	motif II; other site
718252004213	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252004214	metal-binding site [ion binding]
718252004215	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
718252004216	putative homodimer interface [polypeptide binding]; other site
718252004217	putative homotetramer interface [polypeptide binding]; other site
718252004218	putative allosteric switch controlling residues; other site
718252004219	putative metal binding site [ion binding]; other site
718252004220	putative homodimer-homodimer interface [polypeptide binding]; other site
718252004221	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
718252004222	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718252004223	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
718252004224	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
718252004225	active site
718252004226	dimer interface [polypeptide binding]; other site
718252004227	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
718252004228	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
718252004229	active site
718252004230	FMN binding site [chemical binding]; other site
718252004231	substrate binding site [chemical binding]; other site
718252004232	3Fe-4S cluster binding site [ion binding]; other site
718252004233	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
718252004234	domain interface; other site
718252004235	hybrid cluster protein; Provisional; Region: PRK05290
718252004236	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252004237	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252004238	ACS interaction site; other site
718252004239	CODH interaction site; other site
718252004240	metal cluster binding site [ion binding]; other site
718252004241	glutamate dehydrogenase; Provisional; Region: PRK09414
718252004242	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
718252004243	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
718252004244	NAD(P) binding site [chemical binding]; other site
718252004245	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718252004246	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
718252004247	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
718252004248	active site
718252004249	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718252004250	substrate binding site [chemical binding]; other site
718252004251	catalytic residues [active]
718252004252	dimer interface [polypeptide binding]; other site
718252004253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252004254	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718252004255	active site
718252004256	motif I; other site
718252004257	motif II; other site
718252004258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252004259	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718252004260	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718252004261	active site
718252004262	hypothetical protein; Reviewed; Region: PRK00024
718252004263	Helix-hairpin-helix motif; Region: HHH; pfam00633
718252004264	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
718252004265	MPN+ (JAMM) motif; other site
718252004266	Zinc-binding site [ion binding]; other site
718252004267	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
718252004268	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
718252004269	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252004270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252004271	dimer interface [polypeptide binding]; other site
718252004272	conserved gate region; other site
718252004273	putative PBP binding loops; other site
718252004274	ABC-ATPase subunit interface; other site
718252004275	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718252004276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252004277	dimer interface [polypeptide binding]; other site
718252004278	conserved gate region; other site
718252004279	putative PBP binding loops; other site
718252004280	ABC-ATPase subunit interface; other site
718252004281	carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850
718252004282	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718252004283	Cupin domain; Region: Cupin_2; pfam07883
718252004284	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718252004285	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252004286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252004287	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
718252004288	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252004289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252004290	active site
718252004291	phosphorylation site [posttranslational modification]
718252004292	intermolecular recognition site; other site
718252004293	dimerization interface [polypeptide binding]; other site
718252004294	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252004295	DNA binding site [nucleotide binding]
718252004296	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
718252004297	Ligand Binding Site [chemical binding]; other site
718252004298	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
718252004299	GAF domain; Region: GAF_3; pfam13492
718252004300	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
718252004301	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252004302	dimer interface [polypeptide binding]; other site
718252004303	phosphorylation site [posttranslational modification]
718252004304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252004305	ATP binding site [chemical binding]; other site
718252004306	Mg2+ binding site [ion binding]; other site
718252004307	G-X-G motif; other site
718252004308	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
718252004309	TrkA-N domain; Region: TrkA_N; pfam02254
718252004310	TrkA-C domain; Region: TrkA_C; pfam02080
718252004311	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
718252004312	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
718252004313	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718252004314	ParB-like nuclease domain; Region: ParBc; pfam02195
718252004315	MobA/MobL family; Region: MobA_MobL; pfam03389
718252004316	CHC2 zinc finger; Region: zf-CHC2; cl17510
718252004317	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
718252004318	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
718252004319	active site
718252004320	metal binding site [ion binding]; metal-binding site
718252004321	interdomain interaction site; other site
718252004322	AAA domain; Region: AAA_25; pfam13481
718252004323	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252004324	Walker A motif; other site
718252004325	ATP binding site [chemical binding]; other site
718252004326	Walker B motif; other site
718252004327	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
718252004328	DNA binding residues [nucleotide binding]
718252004329	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
718252004330	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252004331	Walker A motif; other site
718252004332	ATP binding site [chemical binding]; other site
718252004333	Walker B motif; other site
718252004334	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718252004335	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718252004336	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718252004337	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
718252004338	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
718252004339	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718252004340	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252004341	motif II; other site
718252004342	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
718252004343	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
718252004344	putative active site [active]
718252004345	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718252004346	dimer interface [polypeptide binding]; other site
718252004347	active site
718252004348	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
718252004349	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
718252004350	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
718252004351	active site
718252004352	phosphorylation site [posttranslational modification]
718252004353	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
718252004354	active pocket/dimerization site; other site
718252004355	active site
718252004356	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718252004357	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252004358	DNA-binding site [nucleotide binding]; DNA binding site
718252004359	UTRA domain; Region: UTRA; pfam07702
718252004360	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252004361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252004362	non-specific DNA binding site [nucleotide binding]; other site
718252004363	salt bridge; other site
718252004364	sequence-specific DNA binding site [nucleotide binding]; other site
718252004365	CHC2 zinc finger; Region: zf-CHC2; cl17510
718252004366	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
718252004367	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252004368	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252004369	active site
718252004370	DNA binding site [nucleotide binding]
718252004371	Int/Topo IB signature motif; other site
718252004372	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718252004373	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
718252004374	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
718252004375	L-serine binding site [chemical binding]; other site
718252004376	trigger factor; Provisional; Region: tig; PRK01490
718252004377	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718252004378	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718252004379	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
718252004380	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
718252004381	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718252004382	MarR family; Region: MarR_2; pfam12802
718252004383	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
718252004384	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
718252004385	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
718252004386	G1 box; other site
718252004387	GTP/Mg2+ binding site [chemical binding]; other site
718252004388	Switch I region; other site
718252004389	G2 box; other site
718252004390	G3 box; other site
718252004391	Switch II region; other site
718252004392	G4 box; other site
718252004393	G5 box; other site
718252004394	Nucleoside recognition; Region: Gate; pfam07670
718252004395	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
718252004396	Nucleoside recognition; Region: Gate; pfam07670
718252004397	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
718252004398	UDP-glucose 4-epimerase; Region: PLN02240
718252004399	NAD binding site [chemical binding]; other site
718252004400	homodimer interface [polypeptide binding]; other site
718252004401	active site
718252004402	substrate binding site [chemical binding]; other site
718252004403	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
718252004404	active site
718252004405	catalytic residues [active]
718252004406	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
718252004407	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
718252004408	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
718252004409	4Fe-4S binding domain; Region: Fer4; cl02805
718252004410	putative methyltransferase; Provisional; Region: PRK14967
718252004411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252004412	S-adenosylmethionine binding site [chemical binding]; other site
718252004413	Predicted methyltransferases [General function prediction only]; Region: COG0313
718252004414	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
718252004415	putative SAM binding site [chemical binding]; other site
718252004416	putative homodimer interface [polypeptide binding]; other site
718252004417	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
718252004418	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
718252004419	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
718252004420	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
718252004421	DNA polymerase III subunit delta'; Validated; Region: PRK08485
718252004422	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
718252004423	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718252004424	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
718252004425	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718252004426	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718252004427	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
718252004428	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
718252004429	trimer interface [polypeptide binding]; other site
718252004430	putative metal binding site [ion binding]; other site
718252004431	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
718252004432	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
718252004433	dimer interface [polypeptide binding]; other site
718252004434	PYR/PP interface [polypeptide binding]; other site
718252004435	TPP binding site [chemical binding]; other site
718252004436	substrate binding site [chemical binding]; other site
718252004437	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718252004438	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
718252004439	Domain of unknown function; Region: EKR; pfam10371
718252004440	4Fe-4S binding domain; Region: Fer4_6; pfam12837
718252004441	4Fe-4S binding domain; Region: Fer4; pfam00037
718252004442	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
718252004443	TPP-binding site [chemical binding]; other site
718252004444	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
718252004445	dimer interface [polypeptide binding]; other site
718252004446	ADP-ribose binding site [chemical binding]; other site
718252004447	active site
718252004448	nudix motif; other site
718252004449	metal binding site [ion binding]; metal-binding site
718252004450	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718252004451	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252004452	DNA-binding site [nucleotide binding]; DNA binding site
718252004453	FCD domain; Region: FCD; pfam07729
718252004454	Predicted membrane protein [Function unknown]; Region: COG1971
718252004455	Domain of unknown function DUF; Region: DUF204; pfam02659
718252004456	DNA gyrase subunit A; Validated; Region: PRK05560
718252004457	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
718252004458	CAP-like domain; other site
718252004459	active site
718252004460	primary dimer interface [polypeptide binding]; other site
718252004461	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718252004462	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718252004463	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718252004464	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718252004465	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718252004466	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718252004467	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
718252004468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252004469	ATP binding site [chemical binding]; other site
718252004470	Mg2+ binding site [ion binding]; other site
718252004471	G-X-G motif; other site
718252004472	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
718252004473	anchoring element; other site
718252004474	dimer interface [polypeptide binding]; other site
718252004475	ATP binding site [chemical binding]; other site
718252004476	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
718252004477	active site
718252004478	putative metal-binding site [ion binding]; other site
718252004479	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
718252004480	recombination protein F; Reviewed; Region: recF; PRK00064
718252004481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252004482	Walker A/P-loop; other site
718252004483	ATP binding site [chemical binding]; other site
718252004484	Q-loop/lid; other site
718252004485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252004486	ABC transporter signature motif; other site
718252004487	Walker B; other site
718252004488	D-loop; other site
718252004489	H-loop/switch region; other site
718252004490	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718252004491	RNA binding surface [nucleotide binding]; other site
718252004492	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
718252004493	DnaA N-terminal domain; Region: DnaA_N; pfam11638
718252004494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252004495	Walker A motif; other site
718252004496	ATP binding site [chemical binding]; other site
718252004497	Walker B motif; other site
718252004498	arginine finger; other site
718252004499	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
718252004500	DnaA box-binding interface [nucleotide binding]; other site
718252004501	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
718252004502	ribonuclease P; Reviewed; Region: rnpA; PRK00499
718252004503	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
718252004504	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
718252004505	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
718252004506	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
718252004507	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
718252004508	G-X-X-G motif; other site
718252004509	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
718252004510	RxxxH motif; other site
718252004511	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
718252004512	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
718252004513	active site
718252004514	metal binding site [ion binding]; metal-binding site
718252004515	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718252004516	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
718252004517	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
718252004518	trmE is a tRNA modification GTPase; Region: trmE; cd04164
718252004519	G1 box; other site
718252004520	GTP/Mg2+ binding site [chemical binding]; other site
718252004521	Switch I region; other site
718252004522	G2 box; other site
718252004523	Switch II region; other site
718252004524	G3 box; other site
718252004525	G4 box; other site
718252004526	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
718252004527	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
718252004528	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
718252004529	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
718252004530	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
718252004531	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
718252004532	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
718252004533	ParB-like nuclease domain; Region: ParB; smart00470
718252004534	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718252004535	ParB-like nuclease domain; Region: ParB; smart00470
718252004536	seryl-tRNA synthetase; Provisional; Region: PRK05431
718252004537	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
718252004538	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718252004539	motif 1; other site
718252004540	dimer interface [polypeptide binding]; other site
718252004541	active site
718252004542	motif 2; other site
718252004543	motif 3; other site
718252004544	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
718252004545	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
718252004546	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
718252004547	classical (c) SDRs; Region: SDR_c; cd05233
718252004548	NAD(P) binding site [chemical binding]; other site
718252004549	active site
718252004550	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
718252004551	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252004552	motif II; other site
718252004553	Bacterial PH domain; Region: DUF304; cl01348
718252004554	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
718252004555	TrkA-N domain; Region: TrkA_N; pfam02254
718252004556	TrkA-C domain; Region: TrkA_C; pfam02080
718252004557	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
718252004558	TrkA-N domain; Region: TrkA_N; pfam02254
718252004559	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
718252004560	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
718252004561	Uncharacterized conserved protein [Function unknown]; Region: COG2006
718252004562	4Fe-4S binding domain; Region: Fer4; pfam00037
718252004563	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
718252004564	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
718252004565	active site
718252004566	metal binding site [ion binding]; metal-binding site
718252004567	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
718252004568	active site
718252004569	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
718252004570	Carbon starvation protein CstA; Region: CstA; pfam02554
718252004571	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
718252004572	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
718252004573	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718252004574	catalytic core [active]
718252004575	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252004576	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718252004577	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
718252004578	AAA domain; Region: AAA_23; pfam13476
718252004579	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
718252004580	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
718252004581	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
718252004582	DRTGG domain; Region: DRTGG; pfam07085
718252004583	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
718252004584	DHHA2 domain; Region: DHHA2; pfam02833
718252004585	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252004586	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718252004587	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252004588	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718252004589	Type III pantothenate kinase; Region: Pan_kinase; cl17198
718252004590	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
718252004591	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
718252004592	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
718252004593	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
718252004594	Ligand binding site [chemical binding]; other site
718252004595	Electron transfer flavoprotein domain; Region: ETF; pfam01012
718252004596	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
718252004597	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
718252004598	FAD binding site [chemical binding]; other site
718252004599	homotetramer interface [polypeptide binding]; other site
718252004600	substrate binding pocket [chemical binding]; other site
718252004601	catalytic base [active]
718252004602	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
718252004603	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
718252004604	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
718252004605	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
718252004606	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
718252004607	substrate binding site [chemical binding]; other site
718252004608	oxyanion hole (OAH) forming residues; other site
718252004609	trimer interface [polypeptide binding]; other site
718252004610	putative acyltransferase; Provisional; Region: PRK05790
718252004611	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
718252004612	dimer interface [polypeptide binding]; other site
718252004613	active site
718252004614	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
718252004615	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
718252004616	active site
718252004617	(T/H)XGH motif; other site
718252004618	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
718252004619	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
718252004620	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
718252004621	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
718252004622	Domain of unknown function DUF20; Region: UPF0118; pfam01594
718252004623	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
718252004624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252004625	FeS/SAM binding site; other site
718252004626	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
718252004627	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718252004628	pyrroline-5-carboxylate reductase; Region: PLN02688
718252004629	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
718252004630	gamma-glutamyl kinase; Provisional; Region: PRK05429
718252004631	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
718252004632	nucleotide binding site [chemical binding]; other site
718252004633	homotetrameric interface [polypeptide binding]; other site
718252004634	putative phosphate binding site [ion binding]; other site
718252004635	putative allosteric binding site; other site
718252004636	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
718252004637	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
718252004638	putative catalytic cysteine [active]
718252004639	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
718252004640	substrate binding site [chemical binding]; other site
718252004641	FMN-binding domain; Region: FMN_bind; pfam04205
718252004642	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
718252004643	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252004644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252004645	active site
718252004646	phosphorylation site [posttranslational modification]
718252004647	intermolecular recognition site; other site
718252004648	dimerization interface [polypeptide binding]; other site
718252004649	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252004650	DNA binding site [nucleotide binding]
718252004651	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252004652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252004653	ATP binding site [chemical binding]; other site
718252004654	Mg2+ binding site [ion binding]; other site
718252004655	G-X-G motif; other site
718252004656	Aluminium resistance protein; Region: Alum_res; pfam06838
718252004657	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
718252004658	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710
718252004659	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718252004660	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718252004661	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
718252004662	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
718252004663	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
718252004664	dimer interface [polypeptide binding]; other site
718252004665	active site
718252004666	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
718252004667	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
718252004668	NAD(P) binding site [chemical binding]; other site
718252004669	homotetramer interface [polypeptide binding]; other site
718252004670	homodimer interface [polypeptide binding]; other site
718252004671	active site
718252004672	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
718252004673	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
718252004674	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
718252004675	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
718252004676	FMN binding site [chemical binding]; other site
718252004677	substrate binding site [chemical binding]; other site
718252004678	putative catalytic residue [active]
718252004679	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
718252004680	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
718252004681	FMN binding site [chemical binding]; other site
718252004682	substrate binding site [chemical binding]; other site
718252004683	putative catalytic residue [active]
718252004684	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
718252004685	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
718252004686	dimer interface [polypeptide binding]; other site
718252004687	active site
718252004688	CoA binding pocket [chemical binding]; other site
718252004689	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
718252004690	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
718252004691	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
718252004692	Ribosomal L32p protein family; Region: Ribosomal_L32p; pfam01783
718252004693	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
718252004694	acyl carrier protein; Provisional; Region: acpP; PRK00982
718252004695	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
718252004696	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718252004697	putative metal binding site [ion binding]; other site
718252004698	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718252004699	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718252004700	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252004701	Pleckstrin homology-like domain; Region: PH-like; cl17171
718252004702	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
718252004703	Predicted permeases [General function prediction only]; Region: COG0679
718252004704	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
718252004705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252004706	Coenzyme A binding pocket [chemical binding]; other site
718252004707	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252004708	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252004709	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
718252004710	Walker A/P-loop; other site
718252004711	ATP binding site [chemical binding]; other site
718252004712	Q-loop/lid; other site
718252004713	ABC transporter signature motif; other site
718252004714	Walker B; other site
718252004715	D-loop; other site
718252004716	H-loop/switch region; other site
718252004717	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
718252004718	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
718252004719	FAD binding pocket [chemical binding]; other site
718252004720	FAD binding motif [chemical binding]; other site
718252004721	phosphate binding motif [ion binding]; other site
718252004722	beta-alpha-beta structure motif; other site
718252004723	NAD binding pocket [chemical binding]; other site
718252004724	Iron coordination center [ion binding]; other site
718252004725	putative oxidoreductase; Provisional; Region: PRK12831
718252004726	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252004727	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718252004728	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
718252004729	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718252004730	NAD binding site [chemical binding]; other site
718252004731	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718252004732	endonuclease III; Region: ENDO3c; smart00478
718252004733	minor groove reading motif; other site
718252004734	helix-hairpin-helix signature motif; other site
718252004735	substrate binding pocket [chemical binding]; other site
718252004736	active site
718252004737	GMP synthase; Reviewed; Region: guaA; PRK00074
718252004738	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
718252004739	AMP/PPi binding site [chemical binding]; other site
718252004740	candidate oxyanion hole; other site
718252004741	catalytic triad [active]
718252004742	potential glutamine specificity residues [chemical binding]; other site
718252004743	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
718252004744	ATP Binding subdomain [chemical binding]; other site
718252004745	Ligand Binding sites [chemical binding]; other site
718252004746	Dimerization subdomain; other site
718252004747	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
718252004748	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
718252004749	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
718252004750	Na2 binding site [ion binding]; other site
718252004751	putative substrate binding site 1 [chemical binding]; other site
718252004752	Na binding site 1 [ion binding]; other site
718252004753	putative substrate binding site 2 [chemical binding]; other site
718252004754	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
718252004755	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
718252004756	active site
718252004757	metal binding site [ion binding]; metal-binding site
718252004758	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
718252004759	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252004760	active site
718252004761	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
718252004762	nucleotide binding site/active site [active]
718252004763	HIT family signature motif; other site
718252004764	catalytic residue [active]
718252004765	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
718252004766	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
718252004767	motif 1; other site
718252004768	active site
718252004769	motif 2; other site
718252004770	motif 3; other site
718252004771	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
718252004772	DHHA1 domain; Region: DHHA1; pfam02272
718252004773	Nuclease-related domain; Region: NERD; pfam08378
718252004774	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718252004775	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
718252004776	active site
718252004777	substrate binding site [chemical binding]; other site
718252004778	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
718252004779	FMN binding site [chemical binding]; other site
718252004780	putative catalytic residues [active]
718252004781	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
718252004782	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
718252004783	catalytic triad [active]
718252004784	topology modulation protein; Provisional; Region: PRK07261
718252004785	AAA domain; Region: AAA_17; pfam13207
718252004786	Ferredoxin [Energy production and conversion]; Region: COG1146
718252004787	4Fe-4S binding domain; Region: Fer4_6; pfam12837
718252004788	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
718252004789	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
718252004790	putative active site [active]
718252004791	(T/H)XGH motif; other site
718252004792	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
718252004793	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
718252004794	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252004795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252004796	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252004797	dimerization interface [polypeptide binding]; other site
718252004798	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
718252004799	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
718252004800	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718252004801	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
718252004802	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
718252004803	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
718252004804	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
718252004805	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
718252004806	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
718252004807	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
718252004808	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
718252004809	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718252004810	minor groove reading motif; other site
718252004811	helix-hairpin-helix signature motif; other site
718252004812	active site
718252004813	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252004814	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252004815	catalytic residues [active]
718252004816	catalytic nucleophile [active]
718252004817	Recombinase; Region: Recombinase; pfam07508
718252004818	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252004819	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252004820	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
718252004821	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
718252004822	peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost
718252004823	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718252004824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252004825	Walker A/P-loop; other site
718252004826	ATP binding site [chemical binding]; other site
718252004827	Q-loop/lid; other site
718252004828	ABC transporter signature motif; other site
718252004829	Walker B; other site
718252004830	D-loop; other site
718252004831	H-loop/switch region; other site
718252004832	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252004833	hypothetical protein; Provisional; Region: PRK12472
718252004834	Predicted ATPase [General function prediction only]; Region: COG3910
718252004835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252004836	Walker A/P-loop; other site
718252004837	ATP binding site [chemical binding]; other site
718252004838	Q-loop/lid; other site
718252004839	ABC transporter signature motif; other site
718252004840	Walker B; other site
718252004841	D-loop; other site
718252004842	H-loop/switch region; other site
718252004843	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
718252004844	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
718252004845	YodL-like; Region: YodL; pfam14191
718252004846	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252004847	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
718252004848	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252004849	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252004850	AAA-like domain; Region: AAA_10; pfam12846
718252004851	Domain of unknown function DUF87; Region: DUF87; pfam01935
718252004852	Maff2 family; Region: Maff2; pfam12750
718252004853	Maff2 family; Region: Maff2; pfam12750
718252004854	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
718252004855	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252004856	Walker A motif; other site
718252004857	ATP binding site [chemical binding]; other site
718252004858	Walker B motif; other site
718252004859	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
718252004860	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
718252004861	ParB-like nuclease domain; Region: ParBc; pfam02195
718252004862	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252004863	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252004864	P-loop; other site
718252004865	Magnesium ion binding site [ion binding]; other site
718252004866	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252004867	Magnesium ion binding site [ion binding]; other site
718252004868	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718252004869	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
718252004870	active site
718252004871	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718252004872	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252004873	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252004874	Magnesium ion binding site [ion binding]; other site
718252004875	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252004876	catalytic nucleophile [active]
718252004877	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252004878	Virulence protein [General function prediction only]; Region: COG3943
718252004879	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
718252004880	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
718252004881	Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683
718252004882	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
718252004883	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252004884	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718252004885	putative catalytic residues [active]
718252004886	catalytic nucleophile [active]
718252004887	Recombinase; Region: Recombinase; pfam07508
718252004888	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252004889	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718252004890	MobA/MobL family; Region: MobA_MobL; pfam03389
718252004891	LemA family; Region: LemA; cl00742
718252004892	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
718252004893	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
718252004894	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252004895	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
718252004896	catalytic residues [active]
718252004897	Recombinase; Region: Recombinase; pfam07508
718252004898	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252004899	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718252004900	Maff2 family; Region: Maff2; pfam12750
718252004901	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252004902	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252004903	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252004904	non-specific DNA binding site [nucleotide binding]; other site
718252004905	salt bridge; other site
718252004906	sequence-specific DNA binding site [nucleotide binding]; other site
718252004907	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718252004908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
718252004909	putative Zn2+ binding site [ion binding]; other site
718252004910	putative DNA binding site [nucleotide binding]; other site
718252004911	MobA/MobL family; Region: MobA_MobL; pfam03389
718252004912	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252004913	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718252004914	putative catalytic residues [active]
718252004915	catalytic nucleophile [active]
718252004916	Recombinase; Region: Recombinase; pfam07508
718252004917	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252004918	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718252004919	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
718252004920	AAA-like domain; Region: AAA_10; pfam12846
718252004921	Domain of unknown function DUF87; Region: DUF87; pfam01935
718252004922	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
718252004923	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
718252004924	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
718252004925	metal binding site [ion binding]; metal-binding site
718252004926	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
718252004927	MobA/MobL family; Region: MobA_MobL; pfam03389
718252004928	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252004929	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718252004930	putative catalytic residues [active]
718252004931	catalytic nucleophile [active]
718252004932	Recombinase; Region: Recombinase; pfam07508
718252004933	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252004934	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718252004935	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
718252004936	ATP cone domain; Region: ATP-cone; pfam03477
718252004937	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
718252004938	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
718252004939	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
718252004940	DEAD-like helicases superfamily; Region: DEXDc; smart00487
718252004941	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252004942	ATP binding site [chemical binding]; other site
718252004943	putative Mg++ binding site [ion binding]; other site
718252004944	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252004945	nucleotide binding region [chemical binding]; other site
718252004946	ATP-binding site [chemical binding]; other site
718252004947	HRDC domain; Region: HRDC; pfam00570
718252004948	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718252004949	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718252004950	active site
718252004951	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
718252004952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252004953	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718252004954	Walker A motif; other site
718252004955	ATP binding site [chemical binding]; other site
718252004956	Walker B motif; other site
718252004957	arginine finger; other site
718252004958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252004959	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718252004960	Walker A motif; other site
718252004961	ATP binding site [chemical binding]; other site
718252004962	Walker B motif; other site
718252004963	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718252004964	translocation protein TolB; Provisional; Region: tolB; PRK01742
718252004965	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
718252004966	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
718252004967	dimerization interface 3.5A [polypeptide binding]; other site
718252004968	active site
718252004969	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
718252004970	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
718252004971	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718252004972	Walker A/P-loop; other site
718252004973	ATP binding site [chemical binding]; other site
718252004974	Q-loop/lid; other site
718252004975	ABC transporter signature motif; other site
718252004976	Walker B; other site
718252004977	D-loop; other site
718252004978	H-loop/switch region; other site
718252004979	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
718252004980	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718252004981	Walker A/P-loop; other site
718252004982	ATP binding site [chemical binding]; other site
718252004983	Q-loop/lid; other site
718252004984	ABC transporter signature motif; other site
718252004985	Walker B; other site
718252004986	D-loop; other site
718252004987	H-loop/switch region; other site
718252004988	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
718252004989	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
718252004990	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
718252004991	active site
718252004992	substrate binding site [chemical binding]; other site
718252004993	metal binding site [ion binding]; metal-binding site
718252004994	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
718252004995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252004996	Walker A motif; other site
718252004997	ATP binding site [chemical binding]; other site
718252004998	Walker B motif; other site
718252004999	arginine finger; other site
718252005000	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
718252005001	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
718252005002	RuvA N terminal domain; Region: RuvA_N; pfam01330
718252005003	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
718252005004	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
718252005005	putative active site [active]
718252005006	putative NTP binding site [chemical binding]; other site
718252005007	putative nucleic acid binding site [nucleotide binding]; other site
718252005008	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252005009	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718252005010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718252005011	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718252005012	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
718252005013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252005014	FeS/SAM binding site; other site
718252005015	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
718252005016	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
718252005017	FMN binding site [chemical binding]; other site
718252005018	active site
718252005019	catalytic residues [active]
718252005020	substrate binding site [chemical binding]; other site
718252005021	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
718252005022	PemK-like protein; Region: PemK; pfam02452
718252005023	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
718252005024	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
718252005025	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
718252005026	Fumarase C-terminus; Region: Fumerase_C; cl00795
718252005027	fumarate hydratase; Provisional; Region: PRK06246
718252005028	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
718252005029	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
718252005030	Malic enzyme, N-terminal domain; Region: malic; pfam00390
718252005031	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
718252005032	putative NAD(P) binding site [chemical binding]; other site
718252005033	Rrf2 family protein; Region: rrf2_super; TIGR00738
718252005034	Transcriptional regulator; Region: Rrf2; cl17282
718252005035	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
718252005036	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
718252005037	dimer interface [polypeptide binding]; other site
718252005038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252005039	catalytic residue [active]
718252005040	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
718252005041	Clp amino terminal domain; Region: Clp_N; pfam02861
718252005042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252005043	Walker A motif; other site
718252005044	ATP binding site [chemical binding]; other site
718252005045	Walker B motif; other site
718252005046	arginine finger; other site
718252005047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252005048	Walker A motif; other site
718252005049	ATP binding site [chemical binding]; other site
718252005050	Walker B motif; other site
718252005051	arginine finger; other site
718252005052	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
718252005053	EDD domain protein, DegV family; Region: DegV; TIGR00762
718252005054	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718252005055	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
718252005056	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
718252005057	GDP-binding site [chemical binding]; other site
718252005058	ACT binding site; other site
718252005059	IMP binding site; other site
718252005060	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
718252005061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718252005062	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
718252005063	putative substrate translocation pore; other site
718252005064	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
718252005065	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718252005066	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252005067	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
718252005068	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
718252005069	electron transport complex RsxE subunit; Provisional; Region: PRK12405
718252005070	FMN-binding domain; Region: FMN_bind; cl01081
718252005071	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
718252005072	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
718252005073	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252005074	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
718252005075	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
718252005076	Probable Catalytic site; other site
718252005077	metal-binding site
718252005078	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718252005079	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
718252005080	Probable Catalytic site; other site
718252005081	metal-binding site
718252005082	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
718252005083	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
718252005084	Walker A/P-loop; other site
718252005085	ATP binding site [chemical binding]; other site
718252005086	Q-loop/lid; other site
718252005087	ABC transporter signature motif; other site
718252005088	Walker B; other site
718252005089	D-loop; other site
718252005090	H-loop/switch region; other site
718252005091	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
718252005092	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718252005093	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718252005094	Flavoprotein; Region: Flavoprotein; cl08021
718252005095	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
718252005096	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
718252005097	trimerization site [polypeptide binding]; other site
718252005098	active site
718252005099	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
718252005100	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
718252005101	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252005102	catalytic residue [active]
718252005103	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
718252005104	active site residue [active]
718252005105	Transcriptional regulator; Region: Rrf2; cl17282
718252005106	Rrf2 family protein; Region: rrf2_super; TIGR00738
718252005107	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
718252005108	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
718252005109	NADP binding site [chemical binding]; other site
718252005110	homodimer interface [polypeptide binding]; other site
718252005111	active site
718252005112	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
718252005113	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718252005114	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718252005115	substrate binding site [chemical binding]; other site
718252005116	ATP binding site [chemical binding]; other site
718252005117	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
718252005118	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
718252005119	active site
718252005120	intersubunit interface [polypeptide binding]; other site
718252005121	catalytic residue [active]
718252005122	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
718252005123	active site
718252005124	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
718252005125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252005126	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718252005127	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
718252005128	active site
718252005129	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718252005130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252005131	DNA-binding site [nucleotide binding]; DNA binding site
718252005132	FCD domain; Region: FCD; pfam07729
718252005133	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
718252005134	active site
718252005135	catalytic residues [active]
718252005136	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
718252005137	galactarate dehydratase; Region: galactar-dH20; TIGR03248
718252005138	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
718252005139	altronate oxidoreductase; Provisional; Region: PRK03643
718252005140	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718252005141	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718252005142	Glucuronate isomerase; Region: UxaC; pfam02614
718252005143	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
718252005144	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
718252005145	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718252005146	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718252005147	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718252005148	Tubby C 2; Region: Tub_2; cl02043
718252005149	SWIM zinc finger; Region: SWIM; pfam04434
718252005150	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
718252005151	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
718252005152	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252005153	ATP binding site [chemical binding]; other site
718252005154	putative Mg++ binding site [ion binding]; other site
718252005155	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252005156	nucleotide binding region [chemical binding]; other site
718252005157	ATP-binding site [chemical binding]; other site
718252005158	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718252005159	NlpC/P60 family; Region: NLPC_P60; pfam00877
718252005160	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
718252005161	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
718252005162	active site
718252005163	dimer interface [polypeptide binding]; other site
718252005164	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
718252005165	hypothetical protein; Provisional; Region: PRK10621
718252005166	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
718252005167	EDD domain protein, DegV family; Region: DegV; TIGR00762
718252005168	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
718252005169	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
718252005170	nucleoside/Zn binding site; other site
718252005171	dimer interface [polypeptide binding]; other site
718252005172	catalytic motif [active]
718252005173	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
718252005174	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
718252005175	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252005176	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718252005177	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252005178	DNA binding residues [nucleotide binding]
718252005179	Sel1 repeat; Region: Sel1; cl02723
718252005180	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
718252005181	active site residue [active]
718252005182	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
718252005183	metal binding site 2 [ion binding]; metal-binding site
718252005184	putative DNA binding helix; other site
718252005185	metal binding site 1 [ion binding]; metal-binding site
718252005186	dimer interface [polypeptide binding]; other site
718252005187	structural Zn2+ binding site [ion binding]; other site
718252005188	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
718252005189	Ferritin-like domain; Region: Ferritin; pfam00210
718252005190	ferroxidase diiron center [ion binding]; other site
718252005191	peroxiredoxin; Region: AhpC; TIGR03137
718252005192	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
718252005193	dimer interface [polypeptide binding]; other site
718252005194	decamer (pentamer of dimers) interface [polypeptide binding]; other site
718252005195	catalytic triad [active]
718252005196	peroxidatic and resolving cysteines [active]
718252005197	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
718252005198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718252005199	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718252005200	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
718252005201	catalytic residue [active]
718252005202	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
718252005203	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718252005204	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718252005205	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
718252005206	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
718252005207	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718252005208	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718252005209	Q-loop/lid; other site
718252005210	ABC transporter signature motif; other site
718252005211	Walker B; other site
718252005212	D-loop; other site
718252005213	H-loop/switch region; other site
718252005214	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718252005215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252005216	Walker A/P-loop; other site
718252005217	ATP binding site [chemical binding]; other site
718252005218	Q-loop/lid; other site
718252005219	ABC transporter signature motif; other site
718252005220	Walker B; other site
718252005221	D-loop; other site
718252005222	H-loop/switch region; other site
718252005223	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252005224	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252005225	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252005226	Walker A/P-loop; other site
718252005227	ATP binding site [chemical binding]; other site
718252005228	Q-loop/lid; other site
718252005229	ABC transporter signature motif; other site
718252005230	Walker B; other site
718252005231	D-loop; other site
718252005232	H-loop/switch region; other site
718252005233	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252005234	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252005235	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252005236	Walker A/P-loop; other site
718252005237	ATP binding site [chemical binding]; other site
718252005238	Q-loop/lid; other site
718252005239	ABC transporter signature motif; other site
718252005240	Walker B; other site
718252005241	D-loop; other site
718252005242	H-loop/switch region; other site
718252005243	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
718252005244	conserved hypothetical integral membrane protein TIGR02185; Region: Trep_Strep
718252005245	Cobalt transport protein; Region: CbiQ; cl00463
718252005246	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718252005247	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718252005248	Walker A/P-loop; other site
718252005249	ATP binding site [chemical binding]; other site
718252005250	Q-loop/lid; other site
718252005251	ABC transporter signature motif; other site
718252005252	Walker B; other site
718252005253	D-loop; other site
718252005254	H-loop/switch region; other site
718252005255	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
718252005256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252005257	Walker A/P-loop; other site
718252005258	ATP binding site [chemical binding]; other site
718252005259	Q-loop/lid; other site
718252005260	ABC transporter signature motif; other site
718252005261	Walker B; other site
718252005262	D-loop; other site
718252005263	H-loop/switch region; other site
718252005264	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252005265	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252005266	dimerization interface [polypeptide binding]; other site
718252005267	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252005268	dimer interface [polypeptide binding]; other site
718252005269	phosphorylation site [posttranslational modification]
718252005270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252005271	ATP binding site [chemical binding]; other site
718252005272	Mg2+ binding site [ion binding]; other site
718252005273	G-X-G motif; other site
718252005274	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252005275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252005276	active site
718252005277	phosphorylation site [posttranslational modification]
718252005278	intermolecular recognition site; other site
718252005279	dimerization interface [polypeptide binding]; other site
718252005280	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252005281	DNA binding site [nucleotide binding]
718252005282	4Fe-4S binding domain; Region: Fer4_5; pfam12801
718252005283	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
718252005284	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718252005285	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
718252005286	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
718252005287	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718252005288	catalytic residues [active]
718252005289	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
718252005290	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
718252005291	SelR domain; Region: SelR; pfam01641
718252005292	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
718252005293	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718252005294	active site
718252005295	HIGH motif; other site
718252005296	nucleotide binding site [chemical binding]; other site
718252005297	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718252005298	active site
718252005299	KMSKS motif; other site
718252005300	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
718252005301	FMN-binding domain; Region: FMN_bind; pfam04205
718252005302	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718252005303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252005304	Walker A motif; other site
718252005305	ATP binding site [chemical binding]; other site
718252005306	Walker B motif; other site
718252005307	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
718252005308	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252005309	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252005310	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252005311	DNA binding residues [nucleotide binding]
718252005312	ornithine carbamoyltransferase; Validated; Region: PRK02102
718252005313	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718252005314	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718252005315	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
718252005316	catalytic motif [active]
718252005317	Zn binding site [ion binding]; other site
718252005318	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
718252005319	elongation factor G; Reviewed; Region: PRK12740
718252005320	G1 box; other site
718252005321	putative GEF interaction site [polypeptide binding]; other site
718252005322	GTP/Mg2+ binding site [chemical binding]; other site
718252005323	Switch I region; other site
718252005324	G2 box; other site
718252005325	G3 box; other site
718252005326	Switch II region; other site
718252005327	G4 box; other site
718252005328	G5 box; other site
718252005329	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
718252005330	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
718252005331	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
718252005332	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
718252005333	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
718252005334	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
718252005335	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
718252005336	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
718252005337	dimer interface [polypeptide binding]; other site
718252005338	putative anticodon binding site; other site
718252005339	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
718252005340	motif 1; other site
718252005341	active site
718252005342	motif 2; other site
718252005343	motif 3; other site
718252005344	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
718252005345	Low molecular weight phosphatase family; Region: LMWPc; cd00115
718252005346	active site
718252005347	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252005348	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252005349	DNA binding site [nucleotide binding]
718252005350	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
718252005351	homopentamer interface [polypeptide binding]; other site
718252005352	active site
718252005353	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
718252005354	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
718252005355	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
718252005356	dimerization interface [polypeptide binding]; other site
718252005357	active site
718252005358	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
718252005359	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
718252005360	catalytic motif [active]
718252005361	Zn binding site [ion binding]; other site
718252005362	RibD C-terminal domain; Region: RibD_C; cl17279
718252005363	D5 N terminal like; Region: D5_N; cl07360
718252005364	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
718252005365	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
718252005366	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718252005367	ABC-ATPase subunit  interface; other site
718252005368	dimer interface [polypeptide binding]; other site
718252005369	putative PBP binding regions; other site
718252005370	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
718252005371	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
718252005372	Abi-like protein; Region: Abi_2; cl01988
718252005373	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
718252005374	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718252005375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252005376	non-specific DNA binding site [nucleotide binding]; other site
718252005377	salt bridge; other site
718252005378	sequence-specific DNA binding site [nucleotide binding]; other site
718252005379	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
718252005380	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
718252005381	DctM-like transporters; Region: DctM; pfam06808
718252005382	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
718252005383	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
718252005384	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
718252005385	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
718252005386	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
718252005387	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718252005388	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252005389	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252005390	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252005391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252005392	dimer interface [polypeptide binding]; other site
718252005393	conserved gate region; other site
718252005394	putative PBP binding loops; other site
718252005395	ABC-ATPase subunit interface; other site
718252005396	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718252005397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252005398	dimer interface [polypeptide binding]; other site
718252005399	conserved gate region; other site
718252005400	putative PBP binding loops; other site
718252005401	ABC-ATPase subunit interface; other site
718252005402	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718252005403	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718252005404	thymidine kinase; Provisional; Region: PRK04296
718252005405	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
718252005406	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
718252005407	CoA binding domain; Region: CoA_binding; pfam02629
718252005408	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
718252005409	active site
718252005410	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
718252005411	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
718252005412	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
718252005413	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
718252005414	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
718252005415	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
718252005416	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
718252005417	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
718252005418	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
718252005419	putative active site [active]
718252005420	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
718252005421	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252005422	motif II; other site
718252005423	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252005424	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
718252005425	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
718252005426	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
718252005427	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718252005428	homodimer interface [polypeptide binding]; other site
718252005429	substrate-cofactor binding pocket; other site
718252005430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252005431	catalytic residue [active]
718252005432	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
718252005433	ribonuclease Z; Reviewed; Region: PRK00055
718252005434	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
718252005435	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
718252005436	active site
718252005437	NTP binding site [chemical binding]; other site
718252005438	metal binding triad [ion binding]; metal-binding site
718252005439	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
718252005440	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
718252005441	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
718252005442	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
718252005443	Ligand Binding Site [chemical binding]; other site
718252005444	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
718252005445	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
718252005446	putative ATP binding site [chemical binding]; other site
718252005447	putative substrate interface [chemical binding]; other site
718252005448	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
718252005449	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718252005450	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
718252005451	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718252005452	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
718252005453	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
718252005454	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
718252005455	acyl-activating enzyme (AAE) consensus motif; other site
718252005456	putative AMP binding site [chemical binding]; other site
718252005457	putative active site [active]
718252005458	putative CoA binding site [chemical binding]; other site
718252005459	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
718252005460	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
718252005461	acyl-activating enzyme (AAE) consensus motif; other site
718252005462	AMP binding site [chemical binding]; other site
718252005463	active site
718252005464	CoA binding site [chemical binding]; other site
718252005465	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
718252005466	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
718252005467	Alkaline phosphatase homologues; Region: alkPPc; smart00098
718252005468	active site
718252005469	dimer interface [polypeptide binding]; other site
718252005470	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
718252005471	HTH domain; Region: HTH_11; cl17392
718252005472	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
718252005473	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
718252005474	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
718252005475	Chromate transporter; Region: Chromate_transp; pfam02417
718252005476	Chromate transporter; Region: Chromate_transp; pfam02417
718252005477	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252005478	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718252005479	YcxB-like protein; Region: YcxB; pfam14317
718252005480	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252005481	dimerization interface [polypeptide binding]; other site
718252005482	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
718252005483	Histidine kinase; Region: His_kinase; pfam06580
718252005484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252005485	ATP binding site [chemical binding]; other site
718252005486	Mg2+ binding site [ion binding]; other site
718252005487	G-X-G motif; other site
718252005488	Response regulator receiver domain; Region: Response_reg; pfam00072
718252005489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252005490	active site
718252005491	phosphorylation site [posttranslational modification]
718252005492	intermolecular recognition site; other site
718252005493	dimerization interface [polypeptide binding]; other site
718252005494	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252005495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252005496	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718252005497	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
718252005498	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718252005499	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
718252005500	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
718252005501	DctM-like transporters; Region: DctM; pfam06808
718252005502	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
718252005503	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
718252005504	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718252005505	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252005506	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718252005507	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
718252005508	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
718252005509	Walker A/P-loop; other site
718252005510	ATP binding site [chemical binding]; other site
718252005511	Q-loop/lid; other site
718252005512	ABC transporter signature motif; other site
718252005513	Walker B; other site
718252005514	D-loop; other site
718252005515	H-loop/switch region; other site
718252005516	TOBE domain; Region: TOBE_2; pfam08402
718252005517	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
718252005518	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718252005519	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718252005520	mannonate dehydratase; Provisional; Region: PRK03906
718252005521	mannonate dehydratase; Region: uxuA; TIGR00695
718252005522	enolase; Provisional; Region: eno; PRK00077
718252005523	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
718252005524	dimer interface [polypeptide binding]; other site
718252005525	metal binding site [ion binding]; metal-binding site
718252005526	substrate binding pocket [chemical binding]; other site
718252005527	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
718252005528	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
718252005529	putative ligand binding site [chemical binding]; other site
718252005530	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718252005531	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
718252005532	TM-ABC transporter signature motif; other site
718252005533	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
718252005534	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
718252005535	TM-ABC transporter signature motif; other site
718252005536	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
718252005537	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
718252005538	Walker A/P-loop; other site
718252005539	ATP binding site [chemical binding]; other site
718252005540	Q-loop/lid; other site
718252005541	ABC transporter signature motif; other site
718252005542	Walker B; other site
718252005543	D-loop; other site
718252005544	H-loop/switch region; other site
718252005545	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
718252005546	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
718252005547	Walker A/P-loop; other site
718252005548	ATP binding site [chemical binding]; other site
718252005549	Q-loop/lid; other site
718252005550	ABC transporter signature motif; other site
718252005551	Walker B; other site
718252005552	D-loop; other site
718252005553	H-loop/switch region; other site
718252005554	Predicted transcriptional regulators [Transcription]; Region: COG1733
718252005555	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
718252005556	Cupin domain; Region: Cupin_2; cl17218
718252005557	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
718252005558	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252005559	FeS/SAM binding site; other site
718252005560	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
718252005561	Pyruvate formate lyase 1; Region: PFL1; cd01678
718252005562	coenzyme A binding site [chemical binding]; other site
718252005563	active site
718252005564	catalytic residues [active]
718252005565	glycine loop; other site
718252005566	The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921
718252005567	Dehydratase family; Region: ILVD_EDD; pfam00920
718252005568	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
718252005569	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
718252005570	GntP family permease; Region: GntP_permease; pfam02447
718252005571	fructuronate transporter; Provisional; Region: PRK10034; cl15264
718252005572	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
718252005573	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718252005574	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718252005575	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718252005576	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718252005577	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252005578	DNA-binding site [nucleotide binding]; DNA binding site
718252005579	FCD domain; Region: FCD; pfam07729
718252005580	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
718252005581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252005582	S-adenosylmethionine binding site [chemical binding]; other site
718252005583	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
718252005584	Penicillinase repressor; Region: Pencillinase_R; pfam03965
718252005585	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
718252005586	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252005587	catalytic residue [active]
718252005588	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
718252005589	putative ligand binding site [chemical binding]; other site
718252005590	putative NAD binding site [chemical binding]; other site
718252005591	putative catalytic site [active]
718252005592	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
718252005593	L-serine binding site [chemical binding]; other site
718252005594	ACT domain interface; other site
718252005595	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252005596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252005597	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252005598	dimerization interface [polypeptide binding]; other site
718252005599	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
718252005600	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718252005601	transmembrane helices; other site
718252005602	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718252005603	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718252005604	HSP70 interaction site [polypeptide binding]; other site
718252005605	Tetratricopeptide repeat; Region: TPR_16; pfam13432
718252005606	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
718252005607	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252005608	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252005609	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252005610	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
718252005611	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718252005612	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
718252005613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252005614	S-adenosylmethionine binding site [chemical binding]; other site
718252005615	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
718252005616	MraW methylase family; Region: Methyltransf_5; pfam01795
718252005617	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
718252005618	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
718252005619	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718252005620	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718252005621	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718252005622	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
718252005623	Mg++ binding site [ion binding]; other site
718252005624	putative catalytic motif [active]
718252005625	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
718252005626	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
718252005627	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
718252005628	active site
718252005629	homodimer interface [polypeptide binding]; other site
718252005630	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
718252005631	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
718252005632	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718252005633	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718252005634	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718252005635	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718252005636	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718252005637	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718252005638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252005639	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718252005640	active site
718252005641	motif I; other site
718252005642	motif II; other site
718252005643	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718252005644	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
718252005645	active site
718252005646	catalytic site [active]
718252005647	substrate binding site [chemical binding]; other site
718252005648	Uncharacterized conserved protein [Function unknown]; Region: COG0398
718252005649	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
718252005650	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252005651	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252005652	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
718252005653	Walker A/P-loop; other site
718252005654	ATP binding site [chemical binding]; other site
718252005655	Q-loop/lid; other site
718252005656	ABC transporter signature motif; other site
718252005657	Walker B; other site
718252005658	D-loop; other site
718252005659	H-loop/switch region; other site
718252005660	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252005661	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252005662	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252005663	Walker A/P-loop; other site
718252005664	ATP binding site [chemical binding]; other site
718252005665	Q-loop/lid; other site
718252005666	ABC transporter signature motif; other site
718252005667	Walker B; other site
718252005668	D-loop; other site
718252005669	H-loop/switch region; other site
718252005670	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718252005671	MarR family; Region: MarR_2; pfam12802
718252005672	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
718252005673	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
718252005674	active site
718252005675	catalytic site [active]
718252005676	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
718252005677	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
718252005678	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
718252005679	ATP binding site [chemical binding]; other site
718252005680	active site
718252005681	substrate binding site [chemical binding]; other site
718252005682	Uncharacterized conserved protein [Function unknown]; Region: COG1284
718252005683	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
718252005684	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
718252005685	citrate lyase subunit gamma; Provisional; Region: PRK13253
718252005686	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
718252005687	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
718252005688	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252005689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252005690	active site
718252005691	phosphorylation site [posttranslational modification]
718252005692	intermolecular recognition site; other site
718252005693	dimerization interface [polypeptide binding]; other site
718252005694	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252005695	DNA binding site [nucleotide binding]
718252005696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252005697	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252005698	dimer interface [polypeptide binding]; other site
718252005699	phosphorylation site [posttranslational modification]
718252005700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252005701	ATP binding site [chemical binding]; other site
718252005702	Mg2+ binding site [ion binding]; other site
718252005703	G-X-G motif; other site
718252005704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252005705	active site
718252005706	phosphorylation site [posttranslational modification]
718252005707	intermolecular recognition site; other site
718252005708	dimerization interface [polypeptide binding]; other site
718252005709	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
718252005710	Citrate transporter; Region: CitMHS; pfam03600
718252005711	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
718252005712	active site clefts [active]
718252005713	zinc binding site [ion binding]; other site
718252005714	dimer interface [polypeptide binding]; other site
718252005715	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
718252005716	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718252005717	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
718252005718	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
718252005719	HPr interaction site; other site
718252005720	glycerol kinase (GK) interaction site [polypeptide binding]; other site
718252005721	active site
718252005722	phosphorylation site [posttranslational modification]
718252005723	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
718252005724	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718252005725	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718252005726	catalytic residue [active]
718252005727	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
718252005728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252005729	dimer interface [polypeptide binding]; other site
718252005730	phosphorylation site [posttranslational modification]
718252005731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252005732	ATP binding site [chemical binding]; other site
718252005733	Mg2+ binding site [ion binding]; other site
718252005734	G-X-G motif; other site
718252005735	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252005736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252005737	active site
718252005738	phosphorylation site [posttranslational modification]
718252005739	intermolecular recognition site; other site
718252005740	dimerization interface [polypeptide binding]; other site
718252005741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252005742	DNA binding site [nucleotide binding]
718252005743	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
718252005744	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
718252005745	transmembrane helices; other site
718252005746	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
718252005747	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
718252005748	intersubunit interface [polypeptide binding]; other site
718252005749	active site
718252005750	zinc binding site [ion binding]; other site
718252005751	Na+ binding site [ion binding]; other site
718252005752	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
718252005753	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
718252005754	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718252005755	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718252005756	Rubrerythrin [Energy production and conversion]; Region: COG1592
718252005757	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
718252005758	binuclear metal center [ion binding]; other site
718252005759	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
718252005760	iron binding site [ion binding]; other site
718252005761	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718252005762	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
718252005763	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718252005764	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718252005765	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718252005766	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252005767	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252005768	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252005769	dimerization interface [polypeptide binding]; other site
718252005770	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
718252005771	homodimer interaction site [polypeptide binding]; other site
718252005772	cofactor binding site; other site
718252005773	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252005774	non-specific DNA binding site [nucleotide binding]; other site
718252005775	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
718252005776	salt bridge; other site
718252005777	sequence-specific DNA binding site [nucleotide binding]; other site
718252005778	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718252005779	Catalytic site [active]
718252005780	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
718252005781	non-specific DNA binding site [nucleotide binding]; other site
718252005782	salt bridge; other site
718252005783	sequence-specific DNA binding site [nucleotide binding]; other site
718252005784	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
718252005785	conserved cys residue [active]
718252005786	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
718252005787	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
718252005788	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
718252005789	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
718252005790	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
718252005791	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718252005792	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
718252005793	putative L-serine binding site [chemical binding]; other site
718252005794	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718252005795	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
718252005796	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252005797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252005798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252005799	dimerization interface [polypeptide binding]; other site
718252005800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252005801	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718252005802	Walker A motif; other site
718252005803	ATP binding site [chemical binding]; other site
718252005804	Walker B motif; other site
718252005805	arginine finger; other site
718252005806	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527
718252005807	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718252005808	PYR/PP interface [polypeptide binding]; other site
718252005809	dimer interface [polypeptide binding]; other site
718252005810	TPP binding site [chemical binding]; other site
718252005811	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718252005812	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
718252005813	TPP-binding site [chemical binding]; other site
718252005814	dimer interface [polypeptide binding]; other site
718252005815	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
718252005816	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
718252005817	putative valine binding site [chemical binding]; other site
718252005818	dimer interface [polypeptide binding]; other site
718252005819	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
718252005820	ketol-acid reductoisomerase; Provisional; Region: PRK05479
718252005821	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
718252005822	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
718252005823	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
718252005824	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
718252005825	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
718252005826	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
718252005827	Glycoprotease family; Region: Peptidase_M22; pfam00814
718252005828	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
718252005829	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252005830	active site
718252005831	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
718252005832	Flavoprotein; Region: Flavoprotein; pfam02441
718252005833	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
718252005834	Type III pantothenate kinase; Region: Pan_kinase; cl17198
718252005835	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718252005836	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718252005837	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718252005838	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718252005839	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
718252005840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252005841	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
718252005842	Walker A/P-loop; other site
718252005843	ATP binding site [chemical binding]; other site
718252005844	Q-loop/lid; other site
718252005845	ABC transporter signature motif; other site
718252005846	Walker B; other site
718252005847	D-loop; other site
718252005848	H-loop/switch region; other site
718252005849	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718252005850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252005851	dimer interface [polypeptide binding]; other site
718252005852	conserved gate region; other site
718252005853	putative PBP binding loops; other site
718252005854	ABC-ATPase subunit interface; other site
718252005855	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718252005856	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
718252005857	MOSC domain; Region: MOSC; pfam03473
718252005858	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
718252005859	MPT binding site; other site
718252005860	trimer interface [polypeptide binding]; other site
718252005861	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
718252005862	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252005863	FeS/SAM binding site; other site
718252005864	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
718252005865	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
718252005866	trimer interface [polypeptide binding]; other site
718252005867	dimer interface [polypeptide binding]; other site
718252005868	putative active site [active]
718252005869	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
718252005870	putative MPT binding site; other site
718252005871	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
718252005872	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
718252005873	dimer interface [polypeptide binding]; other site
718252005874	putative functional site; other site
718252005875	putative MPT binding site; other site
718252005876	hypothetical protein; Provisional; Region: PRK09947
718252005877	putative oxidoreductase; Provisional; Region: PRK09849
718252005878	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
718252005879	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
718252005880	hypothetical protein; Provisional; Region: PRK09898
718252005881	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252005882	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252005883	FMN-binding domain; Region: FMN_bind; pfam04205
718252005884	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
718252005885	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
718252005886	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
718252005887	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
718252005888	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718252005889	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252005890	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252005891	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
718252005892	Walker A/P-loop; other site
718252005893	ATP binding site [chemical binding]; other site
718252005894	Q-loop/lid; other site
718252005895	ABC transporter signature motif; other site
718252005896	Walker B; other site
718252005897	D-loop; other site
718252005898	H-loop/switch region; other site
718252005899	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
718252005900	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718252005901	nucleotide binding site [chemical binding]; other site
718252005902	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
718252005903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252005904	Walker A motif; other site
718252005905	ATP binding site [chemical binding]; other site
718252005906	Walker B motif; other site
718252005907	arginine finger; other site
718252005908	Peptidase family M41; Region: Peptidase_M41; pfam01434
718252005909	2-isopropylmalate synthase; Validated; Region: PRK03739
718252005910	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
718252005911	active site
718252005912	catalytic residues [active]
718252005913	metal binding site [ion binding]; metal-binding site
718252005914	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
718252005915	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
718252005916	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
718252005917	substrate binding site [chemical binding]; other site
718252005918	ligand binding site [chemical binding]; other site
718252005919	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
718252005920	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
718252005921	substrate binding site [chemical binding]; other site
718252005922	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
718252005923	tartrate dehydrogenase; Provisional; Region: PRK08194
718252005924	threonine dehydratase; Provisional; Region: PRK08198
718252005925	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
718252005926	tetramer interface [polypeptide binding]; other site
718252005927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252005928	catalytic residue [active]
718252005929	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
718252005930	C2 domain; Region: C2; cl14603
718252005931	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
718252005932	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
718252005933	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
718252005934	dimer interface [polypeptide binding]; other site
718252005935	substrate binding site [chemical binding]; other site
718252005936	ATP binding site [chemical binding]; other site
718252005937	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
718252005938	thiamine phosphate binding site [chemical binding]; other site
718252005939	active site
718252005940	pyrophosphate binding site [ion binding]; other site
718252005941	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
718252005942	substrate binding site [chemical binding]; other site
718252005943	multimerization interface [polypeptide binding]; other site
718252005944	ATP binding site [chemical binding]; other site
718252005945	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
718252005946	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
718252005947	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
718252005948	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
718252005949	iron binding site [ion binding]; other site
718252005950	Repair protein; Region: Repair_PSII; pfam04536
718252005951	6-phosphofructokinase; Provisional; Region: PRK03202
718252005952	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718252005953	active site
718252005954	ADP/pyrophosphate binding site [chemical binding]; other site
718252005955	dimerization interface [polypeptide binding]; other site
718252005956	allosteric effector site; other site
718252005957	fructose-1,6-bisphosphate binding site; other site
718252005958	CAAX protease self-immunity; Region: Abi; pfam02517
718252005959	UGMP family protein; Validated; Region: PRK09604
718252005960	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
718252005961	DNA polymerase I; Provisional; Region: PRK05755
718252005962	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
718252005963	active site
718252005964	metal binding site 1 [ion binding]; metal-binding site
718252005965	putative 5' ssDNA interaction site; other site
718252005966	metal binding site 3; metal-binding site
718252005967	metal binding site 2 [ion binding]; metal-binding site
718252005968	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
718252005969	putative DNA binding site [nucleotide binding]; other site
718252005970	putative metal binding site [ion binding]; other site
718252005971	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
718252005972	active site
718252005973	substrate binding site [chemical binding]; other site
718252005974	catalytic site [active]
718252005975	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
718252005976	active site
718252005977	DNA binding site [nucleotide binding]
718252005978	catalytic site [active]
718252005979	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
718252005980	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
718252005981	ArsC family; Region: ArsC; pfam03960
718252005982	catalytic residue [active]
718252005983	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718252005984	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
718252005985	Probable Catalytic site; other site
718252005986	metal-binding site
718252005987	Predicted transcriptional regulators [Transcription]; Region: COG1725
718252005988	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252005989	DNA-binding site [nucleotide binding]; DNA binding site
718252005990	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
718252005991	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718252005992	Walker A/P-loop; other site
718252005993	ATP binding site [chemical binding]; other site
718252005994	Q-loop/lid; other site
718252005995	ABC transporter signature motif; other site
718252005996	Walker B; other site
718252005997	D-loop; other site
718252005998	H-loop/switch region; other site
718252005999	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718252006000	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718252006001	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
718252006002	TM-ABC transporter signature motif; other site
718252006003	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
718252006004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006005	Walker A/P-loop; other site
718252006006	ATP binding site [chemical binding]; other site
718252006007	Q-loop/lid; other site
718252006008	ABC transporter signature motif; other site
718252006009	Walker B; other site
718252006010	D-loop; other site
718252006011	H-loop/switch region; other site
718252006012	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718252006013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006014	dimer interface [polypeptide binding]; other site
718252006015	conserved gate region; other site
718252006016	putative PBP binding loops; other site
718252006017	ABC-ATPase subunit interface; other site
718252006018	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718252006019	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718252006020	substrate binding pocket [chemical binding]; other site
718252006021	membrane-bound complex binding site; other site
718252006022	hinge residues; other site
718252006023	Nitroreductase family; Region: Nitroreductase; pfam00881
718252006024	FMN binding site [chemical binding]; other site
718252006025	dimer interface [polypeptide binding]; other site
718252006026	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
718252006027	Uncharacterized conserved protein [Function unknown]; Region: COG2966
718252006028	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
718252006029	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
718252006030	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
718252006031	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718252006032	Probable Catalytic site; other site
718252006033	metal-binding site
718252006034	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718252006035	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
718252006036	Probable Catalytic site; other site
718252006037	metal-binding site
718252006038	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
718252006039	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
718252006040	substrate binding site; other site
718252006041	tetramer interface; other site
718252006042	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
718252006043	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
718252006044	NADP binding site [chemical binding]; other site
718252006045	active site
718252006046	putative substrate binding site [chemical binding]; other site
718252006047	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
718252006048	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
718252006049	NAD binding site [chemical binding]; other site
718252006050	substrate binding site [chemical binding]; other site
718252006051	homodimer interface [polypeptide binding]; other site
718252006052	active site
718252006053	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718252006054	putative efflux protein, MATE family; Region: matE; TIGR00797
718252006055	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
718252006056	putative DNA-binding protein; Validated; Region: PRK00118
718252006057	signal recognition particle protein; Provisional; Region: PRK10867
718252006058	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
718252006059	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
718252006060	P loop; other site
718252006061	GTP binding site [chemical binding]; other site
718252006062	Signal peptide binding domain; Region: SRP_SPB; pfam02978
718252006063	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
718252006064	KH domain; Region: KH_4; pfam13083
718252006065	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
718252006066	RimM N-terminal domain; Region: RimM; pfam01782
718252006067	PRC-barrel domain; Region: PRC; pfam05239
718252006068	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
718252006069	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718252006070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252006071	Coenzyme A binding pocket [chemical binding]; other site
718252006072	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718252006073	dimerization domain swap beta strand [polypeptide binding]; other site
718252006074	regulatory protein interface [polypeptide binding]; other site
718252006075	active site
718252006076	regulatory phosphorylation site [posttranslational modification]; other site
718252006077	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
718252006078	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
718252006079	GIY-YIG motif/motif A; other site
718252006080	active site
718252006081	catalytic site [active]
718252006082	putative DNA binding site [nucleotide binding]; other site
718252006083	metal binding site [ion binding]; metal-binding site
718252006084	UvrB/uvrC motif; Region: UVR; pfam02151
718252006085	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
718252006086	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
718252006087	DNA binding site [nucleotide binding]
718252006088	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
718252006089	Peptidase family C69; Region: Peptidase_C69; pfam03577
718252006090	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718252006091	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718252006092	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718252006093	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
718252006094	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
718252006095	putative substrate binding site [chemical binding]; other site
718252006096	putative ATP binding site [chemical binding]; other site
718252006097	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
718252006098	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718252006099	active site
718252006100	phosphorylation site [posttranslational modification]
718252006101	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718252006102	active site
718252006103	P-loop; other site
718252006104	phosphorylation site [posttranslational modification]
718252006105	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
718252006106	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
718252006107	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718252006108	putative DNA binding site [nucleotide binding]; other site
718252006109	putative Zn2+ binding site [ion binding]; other site
718252006110	AsnC family; Region: AsnC_trans_reg; pfam01037
718252006111	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
718252006112	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
718252006113	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718252006114	catalytic triad [active]
718252006115	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
718252006116	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
718252006117	acyl-activating enzyme (AAE) consensus motif; other site
718252006118	AMP binding site [chemical binding]; other site
718252006119	active site
718252006120	CoA binding site [chemical binding]; other site
718252006121	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
718252006122	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252006123	Walker A/P-loop; other site
718252006124	ATP binding site [chemical binding]; other site
718252006125	Q-loop/lid; other site
718252006126	ABC transporter signature motif; other site
718252006127	Walker B; other site
718252006128	D-loop; other site
718252006129	H-loop/switch region; other site
718252006130	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252006131	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718252006132	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252006133	Walker A/P-loop; other site
718252006134	ATP binding site [chemical binding]; other site
718252006135	Q-loop/lid; other site
718252006136	ABC transporter signature motif; other site
718252006137	Walker B; other site
718252006138	D-loop; other site
718252006139	H-loop/switch region; other site
718252006140	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252006141	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
718252006142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006143	dimer interface [polypeptide binding]; other site
718252006144	conserved gate region; other site
718252006145	putative PBP binding loops; other site
718252006146	ABC-ATPase subunit interface; other site
718252006147	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718252006148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006149	dimer interface [polypeptide binding]; other site
718252006150	conserved gate region; other site
718252006151	putative PBP binding loops; other site
718252006152	ABC-ATPase subunit interface; other site
718252006153	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718252006154	Ferredoxin [Energy production and conversion]; Region: COG1146
718252006155	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718252006156	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
718252006157	trigger factor; Region: tig; TIGR00115
718252006158	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718252006159	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718252006160	glycogen branching enzyme; Provisional; Region: PRK12313
718252006161	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
718252006162	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
718252006163	active site
718252006164	catalytic site [active]
718252006165	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
718252006166	Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353
718252006167	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
718252006168	active site
718252006169	catalytic site [active]
718252006170	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
718252006171	HTH domain; Region: HTH_11; pfam08279
718252006172	3H domain; Region: 3H; pfam02829
718252006173	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
718252006174	peptidase T; Region: peptidase-T; TIGR01882
718252006175	metal binding site [ion binding]; metal-binding site
718252006176	dimer interface [polypeptide binding]; other site
718252006177	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
718252006178	active site
718252006179	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
718252006180	FeoA domain; Region: FeoA; pfam04023
718252006181	FeoA domain; Region: FeoA; pfam04023
718252006182	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
718252006183	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
718252006184	G1 box; other site
718252006185	GTP/Mg2+ binding site [chemical binding]; other site
718252006186	Switch I region; other site
718252006187	G2 box; other site
718252006188	G3 box; other site
718252006189	Switch II region; other site
718252006190	G4 box; other site
718252006191	G5 box; other site
718252006192	Nucleoside recognition; Region: Gate; pfam07670
718252006193	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
718252006194	Nucleoside recognition; Region: Gate; pfam07670
718252006195	MarR family; Region: MarR_2; pfam12802
718252006196	HflX GTPase family; Region: HflX; cd01878
718252006197	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
718252006198	G1 box; other site
718252006199	GTP/Mg2+ binding site [chemical binding]; other site
718252006200	Switch I region; other site
718252006201	G2 box; other site
718252006202	G3 box; other site
718252006203	Switch II region; other site
718252006204	G4 box; other site
718252006205	G5 box; other site
718252006206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718252006207	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718252006208	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
718252006209	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
718252006210	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
718252006211	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
718252006212	FAD binding site [chemical binding]; other site
718252006213	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
718252006214	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718252006215	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
718252006216	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718252006217	active site
718252006218	HIGH motif; other site
718252006219	nucleotide binding site [chemical binding]; other site
718252006220	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
718252006221	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
718252006222	active site
718252006223	KMSKS motif; other site
718252006224	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
718252006225	tRNA binding surface [nucleotide binding]; other site
718252006226	anticodon binding site; other site
718252006227	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
718252006228	Predicted integral membrane protein [Function unknown]; Region: COG5652
718252006229	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
718252006230	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
718252006231	anti sigma factor interaction site; other site
718252006232	regulatory phosphorylation site [posttranslational modification]; other site
718252006233	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
718252006234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252006235	ATP binding site [chemical binding]; other site
718252006236	Mg2+ binding site [ion binding]; other site
718252006237	G-X-G motif; other site
718252006238	RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885
718252006239	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252006240	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718252006241	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252006242	DNA binding residues [nucleotide binding]
718252006243	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252006244	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
718252006245	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718252006246	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
718252006247	DEAD-like helicases superfamily; Region: DEXDc; smart00487
718252006248	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252006249	ATP binding site [chemical binding]; other site
718252006250	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
718252006251	helicase superfamily c-terminal domain; Region: HELICc; smart00490
718252006252	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
718252006253	active site
718252006254	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
718252006255	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
718252006256	phosphopeptide binding site; other site
718252006257	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
718252006258	active site
718252006259	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
718252006260	Catalytic domain of Protein Kinases; Region: PKc; cd00180
718252006261	active site
718252006262	ATP binding site [chemical binding]; other site
718252006263	substrate binding site [chemical binding]; other site
718252006264	activation loop (A-loop); other site
718252006265	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718252006266	binding surface
718252006267	TPR motif; other site
718252006268	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
718252006269	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
718252006270	phosphopeptide binding site; other site
718252006271	Protein of unknown function (DUF975); Region: DUF975; cl10504
718252006272	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
718252006273	phosphopeptide binding site; other site
718252006274	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
718252006275	phosphopeptide binding site; other site
718252006276	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252006277	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252006278	non-specific DNA binding site [nucleotide binding]; other site
718252006279	salt bridge; other site
718252006280	sequence-specific DNA binding site [nucleotide binding]; other site
718252006281	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
718252006282	GAF domain; Region: GAF; pfam01590
718252006283	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
718252006284	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
718252006285	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
718252006286	Stage III sporulation protein D; Region: SpoIIID; pfam12116
718252006287	sporulation sigma factor SigG; Reviewed; Region: PRK08215
718252006288	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252006289	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718252006290	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252006291	DNA binding residues [nucleotide binding]
718252006292	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
718252006293	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
718252006294	putative active site [active]
718252006295	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252006296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006297	Walker A/P-loop; other site
718252006298	ATP binding site [chemical binding]; other site
718252006299	Q-loop/lid; other site
718252006300	ABC transporter signature motif; other site
718252006301	Walker B; other site
718252006302	D-loop; other site
718252006303	H-loop/switch region; other site
718252006304	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252006305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252006306	active site
718252006307	phosphorylation site [posttranslational modification]
718252006308	intermolecular recognition site; other site
718252006309	dimerization interface [polypeptide binding]; other site
718252006310	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252006311	DNA binding site [nucleotide binding]
718252006312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252006313	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252006314	dimer interface [polypeptide binding]; other site
718252006315	phosphorylation site [posttranslational modification]
718252006316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252006317	ATP binding site [chemical binding]; other site
718252006318	Mg2+ binding site [ion binding]; other site
718252006319	G-X-G motif; other site
718252006320	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718252006321	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718252006322	Walker A/P-loop; other site
718252006323	ATP binding site [chemical binding]; other site
718252006324	Q-loop/lid; other site
718252006325	ABC transporter signature motif; other site
718252006326	Walker B; other site
718252006327	D-loop; other site
718252006328	H-loop/switch region; other site
718252006329	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718252006330	FtsX-like permease family; Region: FtsX; pfam02687
718252006331	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718252006332	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718252006333	FtsX-like permease family; Region: FtsX; pfam02687
718252006334	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252006335	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252006336	catalytic residues [active]
718252006337	catalytic nucleophile [active]
718252006338	Recombinase; Region: Recombinase; pfam07508
718252006339	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252006340	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252006341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252006342	non-specific DNA binding site [nucleotide binding]; other site
718252006343	salt bridge; other site
718252006344	sequence-specific DNA binding site [nucleotide binding]; other site
718252006345	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718252006346	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718252006347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252006348	DNA-binding site [nucleotide binding]; DNA binding site
718252006349	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
718252006350	galactonate dehydratase; Provisional; Region: PRK14017
718252006351	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718252006352	active site pocket [active]
718252006353	galactonate dehydratase; Provisional; Region: PRK14017
718252006354	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718252006355	active site pocket [active]
718252006356	Amino acid permease; Region: AA_permease_2; pfam13520
718252006357	galactonate dehydratase; Provisional; Region: PRK14017
718252006358	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718252006359	active site pocket [active]
718252006360	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
718252006361	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
718252006362	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
718252006363	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
718252006364	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718252006365	nucleotide binding site [chemical binding]; other site
718252006366	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
718252006367	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
718252006368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
718252006369	Cupin domain; Region: Cupin_2; pfam07883
718252006370	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
718252006371	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718252006372	Walker A/P-loop; other site
718252006373	ATP binding site [chemical binding]; other site
718252006374	Q-loop/lid; other site
718252006375	ABC transporter signature motif; other site
718252006376	Walker B; other site
718252006377	D-loop; other site
718252006378	H-loop/switch region; other site
718252006379	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718252006380	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718252006381	ABC-ATPase subunit  interface; other site
718252006382	dimer interface [polypeptide binding]; other site
718252006383	putative PBP binding regions; other site
718252006384	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
718252006385	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
718252006386	intersubunit interface [polypeptide binding]; other site
718252006387	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
718252006388	Methyltransferase domain; Region: Methyltransf_31; pfam13847
718252006389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252006390	S-adenosylmethionine binding site [chemical binding]; other site
718252006391	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718252006392	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
718252006393	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
718252006394	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252006395	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252006396	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252006397	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252006398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006399	Walker A/P-loop; other site
718252006400	ATP binding site [chemical binding]; other site
718252006401	Q-loop/lid; other site
718252006402	ABC transporter signature motif; other site
718252006403	Walker B; other site
718252006404	D-loop; other site
718252006405	H-loop/switch region; other site
718252006406	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718252006407	EamA-like transporter family; Region: EamA; pfam00892
718252006408	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
718252006409	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718252006410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252006411	DNA-binding site [nucleotide binding]; DNA binding site
718252006412	UTRA domain; Region: UTRA; cl17743
718252006413	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
718252006414	transmembrane helices; other site
718252006415	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718252006416	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
718252006417	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718252006418	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718252006419	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718252006420	metal binding site [ion binding]; metal-binding site
718252006421	active site
718252006422	I-site; other site
718252006423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252006424	dimer interface [polypeptide binding]; other site
718252006425	phosphorylation site [posttranslational modification]
718252006426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252006427	ATP binding site [chemical binding]; other site
718252006428	Mg2+ binding site [ion binding]; other site
718252006429	G-X-G motif; other site
718252006430	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
718252006431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252006432	active site
718252006433	phosphorylation site [posttranslational modification]
718252006434	intermolecular recognition site; other site
718252006435	dimerization interface [polypeptide binding]; other site
718252006436	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
718252006437	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718252006438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252006439	motif II; other site
718252006440	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
718252006441	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
718252006442	homodimer interface [polypeptide binding]; other site
718252006443	substrate-cofactor binding pocket; other site
718252006444	catalytic residue [active]
718252006445	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718252006446	Putative esterase; Region: Esterase; pfam00756
718252006447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
718252006448	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
718252006449	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
718252006450	Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749
718252006451	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
718252006452	GIY-YIG motif/motif A; other site
718252006453	putative active site [active]
718252006454	putative metal binding site [ion binding]; other site
718252006455	argininosuccinate synthase; Provisional; Region: PRK13820
718252006456	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
718252006457	ANP binding site [chemical binding]; other site
718252006458	Substrate Binding Site II [chemical binding]; other site
718252006459	Substrate Binding Site I [chemical binding]; other site
718252006460	argininosuccinate lyase; Provisional; Region: PRK00855
718252006461	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
718252006462	active sites [active]
718252006463	tetramer interface [polypeptide binding]; other site
718252006464	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
718252006465	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718252006466	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
718252006467	heterotetramer interface [polypeptide binding]; other site
718252006468	active site pocket [active]
718252006469	cleavage site
718252006470	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
718252006471	homohexameric interface [polypeptide binding]; other site
718252006472	feedback inhibition sensing region; other site
718252006473	nucleotide binding site [chemical binding]; other site
718252006474	N-acetyl-L-glutamate binding site [chemical binding]; other site
718252006475	acetylornithine aminotransferase; Provisional; Region: PRK02627
718252006476	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718252006477	inhibitor-cofactor binding pocket; inhibition site
718252006478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252006479	catalytic residue [active]
718252006480	ornithine carbamoyltransferase; Provisional; Region: PRK00779
718252006481	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718252006482	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718252006483	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718252006484	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
718252006485	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718252006486	catalytic core [active]
718252006487	Helix-turn-helix domain; Region: HTH_17; cl17695
718252006488	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
718252006489	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718252006490	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718252006491	Magnesium ion binding site [ion binding]; other site
718252006492	ParB-like nuclease domain; Region: ParB; smart00470
718252006493	PemK-like protein; Region: PemK; pfam02452
718252006494	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
718252006495	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
718252006496	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252006497	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252006498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006499	Walker A/P-loop; other site
718252006500	ATP binding site [chemical binding]; other site
718252006501	Q-loop/lid; other site
718252006502	ABC transporter signature motif; other site
718252006503	Walker B; other site
718252006504	D-loop; other site
718252006505	H-loop/switch region; other site
718252006506	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
718252006507	H+ Antiporter protein; Region: 2A0121; TIGR00900
718252006508	Domain of unknown function (DUF955); Region: DUF955; pfam06114
718252006509	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252006510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252006511	non-specific DNA binding site [nucleotide binding]; other site
718252006512	salt bridge; other site
718252006513	sequence-specific DNA binding site [nucleotide binding]; other site
718252006514	Y-family of DNA polymerases; Region: PolY; cl12025
718252006515	active site
718252006516	Uncharacterized conserved protein (DUF2363); Region: DUF2363; pfam10155
718252006517	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252006518	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
718252006519	CHC2 zinc finger; Region: zf-CHC2; cl17510
718252006520	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252006521	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252006522	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718252006523	Walker A/P-loop; other site
718252006524	ATP binding site [chemical binding]; other site
718252006525	Q-loop/lid; other site
718252006526	ABC transporter signature motif; other site
718252006527	Walker B; other site
718252006528	D-loop; other site
718252006529	H-loop/switch region; other site
718252006530	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
718252006531	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
718252006532	FeS/SAM binding site; other site
718252006533	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252006534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252006535	non-specific DNA binding site [nucleotide binding]; other site
718252006536	salt bridge; other site
718252006537	sequence-specific DNA binding site [nucleotide binding]; other site
718252006538	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718252006539	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718252006540	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718252006541	putative active site [active]
718252006542	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
718252006543	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
718252006544	putative active site [active]
718252006545	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
718252006546	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718252006547	active site turn [active]
718252006548	phosphorylation site [posttranslational modification]
718252006549	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718252006550	Uncharacterized conserved protein [Function unknown]; Region: COG3589
718252006551	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
718252006552	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
718252006553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718252006554	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
718252006555	Walker A motif; other site
718252006556	ATP binding site [chemical binding]; other site
718252006557	Walker B motif; other site
718252006558	arginine finger; other site
718252006559	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
718252006560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
718252006561	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
718252006562	metal ion-dependent adhesion site (MIDAS); other site
718252006563	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
718252006564	Citrate transporter; Region: CitMHS; pfam03600
718252006565	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
718252006566	CoA-transferase family III; Region: CoA_transf_3; pfam02515
718252006567	N-acetyl-gamma-glutamyl-phosphate reductase, uncommon form; Region: argC_other; TIGR01851
718252006568	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
718252006569	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718252006570	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718252006571	DNA binding site [nucleotide binding]
718252006572	domain linker motif; other site
718252006573	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718252006574	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
718252006575	CoenzymeA binding site [chemical binding]; other site
718252006576	subunit interaction site [polypeptide binding]; other site
718252006577	PHB binding site; other site
718252006578	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252006579	dimerization interface [polypeptide binding]; other site
718252006580	Histidine kinase; Region: His_kinase; pfam06580
718252006581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252006582	ATP binding site [chemical binding]; other site
718252006583	Mg2+ binding site [ion binding]; other site
718252006584	G-X-G motif; other site
718252006585	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
718252006586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252006587	active site
718252006588	phosphorylation site [posttranslational modification]
718252006589	intermolecular recognition site; other site
718252006590	dimerization interface [polypeptide binding]; other site
718252006591	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252006592	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
718252006593	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
718252006594	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718252006595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006596	dimer interface [polypeptide binding]; other site
718252006597	conserved gate region; other site
718252006598	putative PBP binding loops; other site
718252006599	ABC-ATPase subunit interface; other site
718252006600	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718252006601	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252006602	Walker A/P-loop; other site
718252006603	ATP binding site [chemical binding]; other site
718252006604	Q-loop/lid; other site
718252006605	ABC transporter signature motif; other site
718252006606	Walker B; other site
718252006607	D-loop; other site
718252006608	H-loop/switch region; other site
718252006609	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252006610	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
718252006611	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252006612	Walker A/P-loop; other site
718252006613	ATP binding site [chemical binding]; other site
718252006614	Q-loop/lid; other site
718252006615	ABC transporter signature motif; other site
718252006616	Walker B; other site
718252006617	D-loop; other site
718252006618	H-loop/switch region; other site
718252006619	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718252006620	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
718252006621	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
718252006622	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
718252006623	active site
718252006624	catalytic triad [active]
718252006625	oxyanion hole [active]
718252006626	Predicted permeases [General function prediction only]; Region: COG0679
718252006627	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718252006628	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718252006629	nucleotide binding site [chemical binding]; other site
718252006630	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718252006631	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
718252006632	beta-galactosidase; Region: BGL; TIGR03356
718252006633	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252006634	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252006635	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252006636	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
718252006637	putative catalytic residues [active]
718252006638	catalytic nucleophile [active]
718252006639	Recombinase; Region: Recombinase; pfam07508
718252006640	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252006641	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
718252006642	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252006643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252006644	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252006645	dimerization interface [polypeptide binding]; other site
718252006646	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
718252006647	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
718252006648	substrate binding site [chemical binding]; other site
718252006649	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
718252006650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006651	dimer interface [polypeptide binding]; other site
718252006652	conserved gate region; other site
718252006653	putative PBP binding loops; other site
718252006654	ABC-ATPase subunit interface; other site
718252006655	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
718252006656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006657	dimer interface [polypeptide binding]; other site
718252006658	conserved gate region; other site
718252006659	putative PBP binding loops; other site
718252006660	ABC-ATPase subunit interface; other site
718252006661	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252006662	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
718252006663	Walker A/P-loop; other site
718252006664	ATP binding site [chemical binding]; other site
718252006665	Q-loop/lid; other site
718252006666	ABC transporter signature motif; other site
718252006667	Walker B; other site
718252006668	D-loop; other site
718252006669	H-loop/switch region; other site
718252006670	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
718252006671	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252006672	Walker A/P-loop; other site
718252006673	ATP binding site [chemical binding]; other site
718252006674	Q-loop/lid; other site
718252006675	ABC transporter signature motif; other site
718252006676	Walker B; other site
718252006677	D-loop; other site
718252006678	H-loop/switch region; other site
718252006679	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
718252006680	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
718252006681	active site
718252006682	Zn binding site [ion binding]; other site
718252006683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718252006684	active site
718252006685	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
718252006686	GAF domain; Region: GAF_3; pfam13492
718252006687	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
718252006688	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
718252006689	NodB motif; other site
718252006690	putative active site [active]
718252006691	putative catalytic site [active]
718252006692	putative Zn binding site [ion binding]; other site
718252006693	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
718252006694	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718252006695	CotH protein; Region: CotH; pfam08757
718252006696	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
718252006697	putative metal binding residues [ion binding]; other site
718252006698	signature motif; other site
718252006699	dimer interface [polypeptide binding]; other site
718252006700	active site
718252006701	polyP binding site; other site
718252006702	substrate binding site [chemical binding]; other site
718252006703	acceptor-phosphate pocket; other site
718252006704	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
718252006705	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
718252006706	MOFRL family; Region: MOFRL; pfam05161
718252006707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252006708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252006709	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252006710	dimerization interface [polypeptide binding]; other site
718252006711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006712	Walker A/P-loop; other site
718252006713	ATP binding site [chemical binding]; other site
718252006714	Q-loop/lid; other site
718252006715	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
718252006716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006717	ABC transporter signature motif; other site
718252006718	Walker B; other site
718252006719	D-loop; other site
718252006720	H-loop/switch region; other site
718252006721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252006722	AAA domain; Region: AAA_21; pfam13304
718252006723	Walker A/P-loop; other site
718252006724	ATP binding site [chemical binding]; other site
718252006725	Q-loop/lid; other site
718252006726	ABC transporter signature motif; other site
718252006727	Walker B; other site
718252006728	D-loop; other site
718252006729	H-loop/switch region; other site
718252006730	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718252006731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718252006732	substrate binding pocket [chemical binding]; other site
718252006733	membrane-bound complex binding site; other site
718252006734	hinge residues; other site
718252006735	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
718252006736	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718252006737	Walker A/P-loop; other site
718252006738	ATP binding site [chemical binding]; other site
718252006739	Q-loop/lid; other site
718252006740	ABC transporter signature motif; other site
718252006741	Walker B; other site
718252006742	D-loop; other site
718252006743	H-loop/switch region; other site
718252006744	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718252006745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006746	dimer interface [polypeptide binding]; other site
718252006747	conserved gate region; other site
718252006748	putative PBP binding loops; other site
718252006749	ABC-ATPase subunit interface; other site
718252006750	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
718252006751	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718252006752	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
718252006753	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
718252006754	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
718252006755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718252006756	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
718252006757	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
718252006758	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718252006759	Peptidase M16C associated; Region: M16C_assoc; pfam08367
718252006760	Terminase-like family; Region: Terminase_6; pfam03237
718252006761	Protein of unknown function (DUF464); Region: DUF464; pfam04327
718252006762	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
718252006763	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
718252006764	active site
718252006765	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
718252006766	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
718252006767	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718252006768	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
718252006769	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
718252006770	active site
718252006771	Zn binding site [ion binding]; other site
718252006772	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
718252006773	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718252006774	Int/Topo IB signature motif; other site
718252006775	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252006776	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252006777	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252006778	DNA binding residues [nucleotide binding]
718252006779	Protein of unknown function (DUF975); Region: DUF975; cl10504
718252006780	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
718252006781	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
718252006782	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
718252006783	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
718252006784	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
718252006785	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
718252006786	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
718252006787	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
718252006788	Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691
718252006789	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
718252006790	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
718252006791	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252006792	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718252006793	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
718252006794	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
718252006795	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718252006796	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252006797	metal-binding site [ion binding]
718252006798	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718252006799	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252006800	metal-binding site [ion binding]
718252006801	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718252006802	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718252006803	dimerization interface [polypeptide binding]; other site
718252006804	putative DNA binding site [nucleotide binding]; other site
718252006805	putative Zn2+ binding site [ion binding]; other site
718252006806	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
718252006807	L-aspartate oxidase; Provisional; Region: PRK06175
718252006808	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
718252006809	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
718252006810	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
718252006811	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718252006812	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
718252006813	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
718252006814	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
718252006815	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
718252006816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252006817	active site
718252006818	phosphorylation site [posttranslational modification]
718252006819	intermolecular recognition site; other site
718252006820	dimerization interface [polypeptide binding]; other site
718252006821	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252006822	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252006823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252006824	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252006825	dimerization interface [polypeptide binding]; other site
718252006826	Histidine kinase; Region: His_kinase; pfam06580
718252006827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252006828	ATP binding site [chemical binding]; other site
718252006829	Mg2+ binding site [ion binding]; other site
718252006830	G-X-G motif; other site
718252006831	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718252006832	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718252006833	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718252006834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006835	dimer interface [polypeptide binding]; other site
718252006836	conserved gate region; other site
718252006837	putative PBP binding loops; other site
718252006838	ABC-ATPase subunit interface; other site
718252006839	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718252006840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006841	dimer interface [polypeptide binding]; other site
718252006842	conserved gate region; other site
718252006843	putative PBP binding loops; other site
718252006844	ABC-ATPase subunit interface; other site
718252006845	beta-D-glucuronidase; Provisional; Region: PRK10150
718252006846	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252006847	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252006848	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252006849	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
718252006850	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
718252006851	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
718252006852	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
718252006853	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
718252006854	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
718252006855	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
718252006856	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252006857	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252006858	catalytic residues [active]
718252006859	catalytic nucleophile [active]
718252006860	Recombinase; Region: Recombinase; pfam07508
718252006861	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252006862	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
718252006863	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718252006864	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
718252006865	catalytic residues [active]
718252006866	catalytic nucleophile [active]
718252006867	Recombinase; Region: Recombinase; pfam07508
718252006868	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
718252006869	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718252006870	RelB antitoxin; Region: RelB; cl01171
718252006871	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
718252006872	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252006873	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252006874	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718252006875	DNA binding residues [nucleotide binding]
718252006876	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
718252006877	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718252006878	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252006879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252006880	non-specific DNA binding site [nucleotide binding]; other site
718252006881	salt bridge; other site
718252006882	sequence-specific DNA binding site [nucleotide binding]; other site
718252006883	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
718252006884	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718252006885	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
718252006886	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
718252006887	Y-family of DNA polymerases; Region: PolY; cl12025
718252006888	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
718252006889	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
718252006890	ssDNA binding site; other site
718252006891	generic binding surface II; other site
718252006892	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718252006893	ATP binding site [chemical binding]; other site
718252006894	putative Mg++ binding site [ion binding]; other site
718252006895	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718252006896	nucleotide binding region [chemical binding]; other site
718252006897	ATP-binding site [chemical binding]; other site
718252006898	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187
718252006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
718252006900	Mg2+ binding site [ion binding]; other site
718252006901	G-X-G motif; other site
718252006902	DNA gyrase B; Region: DNA_gyraseB; pfam00204
718252006903	ATP binding site [chemical binding]; other site
718252006904	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
718252006905	active site
718252006906	putative metal-binding site [ion binding]; other site
718252006907	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
718252006908	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
718252006909	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
718252006910	CAP-like domain; other site
718252006911	active site
718252006912	primary dimer interface [polypeptide binding]; other site
718252006913	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
718252006914	glycyl-tRNA synthetase; Provisional; Region: PRK04173
718252006915	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718252006916	motif 1; other site
718252006917	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
718252006918	dimer interface [polypeptide binding]; other site
718252006919	motif 1; other site
718252006920	active site
718252006921	motif 2; other site
718252006922	motif 3; other site
718252006923	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
718252006924	anticodon binding site; other site
718252006925	ribosome maturation protein RimP; Reviewed; Region: PRK00092
718252006926	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
718252006927	putative RNA binding site [nucleotide binding]; other site
718252006928	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
718252006929	NusA N-terminal domain; Region: NusA_N; pfam08529
718252006930	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
718252006931	RNA binding site [nucleotide binding]; other site
718252006932	homodimer interface [polypeptide binding]; other site
718252006933	NusA-like KH domain; Region: KH_5; pfam13184
718252006934	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
718252006935	G-X-X-G motif; other site
718252006936	Protein of unknown function (DUF448); Region: DUF448; pfam04296
718252006937	putative RNA binding cleft [nucleotide binding]; other site
718252006938	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
718252006939	translation initiation factor IF-2; Validated; Region: infB; PRK05306
718252006940	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
718252006941	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
718252006942	G1 box; other site
718252006943	putative GEF interaction site [polypeptide binding]; other site
718252006944	GTP/Mg2+ binding site [chemical binding]; other site
718252006945	Switch I region; other site
718252006946	G2 box; other site
718252006947	G3 box; other site
718252006948	Switch II region; other site
718252006949	G4 box; other site
718252006950	G5 box; other site
718252006951	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
718252006952	Translation-initiation factor 2; Region: IF-2; pfam11987
718252006953	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
718252006954	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
718252006955	DHH family; Region: DHH; pfam01368
718252006956	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
718252006957	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
718252006958	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
718252006959	RNA binding site [nucleotide binding]; other site
718252006960	active site
718252006961	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
718252006962	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
718252006963	active site
718252006964	Riboflavin kinase; Region: Flavokinase; pfam01687
718252006965	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
718252006966	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
718252006967	substrate binding pocket [chemical binding]; other site
718252006968	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
718252006969	16S/18S rRNA binding site [nucleotide binding]; other site
718252006970	S13e-L30e interaction site [polypeptide binding]; other site
718252006971	25S rRNA binding site [nucleotide binding]; other site
718252006972	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
718252006973	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
718252006974	RNase E interface [polypeptide binding]; other site
718252006975	trimer interface [polypeptide binding]; other site
718252006976	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
718252006977	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
718252006978	RNase E interface [polypeptide binding]; other site
718252006979	trimer interface [polypeptide binding]; other site
718252006980	active site
718252006981	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
718252006982	putative nucleic acid binding region [nucleotide binding]; other site
718252006983	G-X-X-G motif; other site
718252006984	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
718252006985	RNA binding site [nucleotide binding]; other site
718252006986	domain interface; other site
718252006987	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
718252006988	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
718252006989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252006990	dimer interface [polypeptide binding]; other site
718252006991	conserved gate region; other site
718252006992	ABC-ATPase subunit interface; other site
718252006993	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
718252006994	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718252006995	homodimer interface [polypeptide binding]; other site
718252006996	substrate-cofactor binding pocket; other site
718252006997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718252006998	catalytic residue [active]
718252006999	Homoserine O-succinyltransferase; Region: HTS; pfam04204
718252007000	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
718252007001	proposed active site lysine [active]
718252007002	conserved cys residue [active]
718252007003	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
718252007004	homodimer interface [polypeptide binding]; other site
718252007005	homotetramer interface [polypeptide binding]; other site
718252007006	active site pocket [active]
718252007007	cleavage site
718252007008	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
718252007009	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
718252007010	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718252007011	Ligand binding site; other site
718252007012	Putative Catalytic site; other site
718252007013	DXD motif; other site
718252007014	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
718252007015	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
718252007016	ligand binding site [chemical binding]; other site
718252007017	flexible hinge region; other site
718252007018	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
718252007019	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
718252007020	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
718252007021	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
718252007022	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
718252007023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
718252007024	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
718252007025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718252007026	Walker A/P-loop; other site
718252007027	ATP binding site [chemical binding]; other site
718252007028	Q-loop/lid; other site
718252007029	ABC transporter signature motif; other site
718252007030	Walker B; other site
718252007031	D-loop; other site
718252007032	H-loop/switch region; other site
718252007033	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
718252007034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718252007035	FeS/SAM binding site; other site
718252007036	HemN C-terminal domain; Region: HemN_C; pfam06969
718252007037	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
718252007038	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
718252007039	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
718252007040	toxin interface [polypeptide binding]; other site
718252007041	Zn binding site [ion binding]; other site
718252007042	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
718252007043	Peptidase family M23; Region: Peptidase_M23; pfam01551
718252007044	flavoprotein, HI0933 family; Region: TIGR00275
718252007045	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
718252007046	cytidylate kinase; Provisional; Region: cmk; PRK00023
718252007047	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
718252007048	CMP-binding site; other site
718252007049	The sites determining sugar specificity; other site
718252007050	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
718252007051	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
718252007052	putative acyl-acceptor binding pocket; other site
718252007053	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
718252007054	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
718252007055	RNA binding site [nucleotide binding]; other site
718252007056	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
718252007057	RNA binding site [nucleotide binding]; other site
718252007058	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
718252007059	RNA binding site [nucleotide binding]; other site
718252007060	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
718252007061	RNA binding site [nucleotide binding]; other site
718252007062	Predicted membrane protein [Function unknown]; Region: COG2246
718252007063	GtrA-like protein; Region: GtrA; pfam04138
718252007064	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
718252007065	intersubunit interface [polypeptide binding]; other site
718252007066	active site
718252007067	catalytic residue [active]
718252007068	S-adenosylmethionine synthetase; Validated; Region: PRK05250
718252007069	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
718252007070	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
718252007071	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
718252007072	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
718252007073	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
718252007074	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252007075	active site
718252007076	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
718252007077	putative binding surface; other site
718252007078	active site
718252007079	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718252007080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718252007081	metal binding site [ion binding]; metal-binding site
718252007082	active site
718252007083	I-site; other site
718252007084	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
718252007085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252007086	active site
718252007087	phosphorylation site [posttranslational modification]
718252007088	intermolecular recognition site; other site
718252007089	dimerization interface [polypeptide binding]; other site
718252007090	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252007091	Zn2+ binding site [ion binding]; other site
718252007092	Mg2+ binding site [ion binding]; other site
718252007093	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
718252007094	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
718252007095	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
718252007096	ligand binding site [chemical binding]; other site
718252007097	calcium binding site [ion binding]; other site
718252007098	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
718252007099	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
718252007100	Walker A/P-loop; other site
718252007101	ATP binding site [chemical binding]; other site
718252007102	Q-loop/lid; other site
718252007103	ABC transporter signature motif; other site
718252007104	Walker B; other site
718252007105	D-loop; other site
718252007106	H-loop/switch region; other site
718252007107	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718252007108	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
718252007109	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
718252007110	putative binding surface; other site
718252007111	active site
718252007112	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
718252007113	active site
718252007114	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718252007115	EamA-like transporter family; Region: EamA; pfam00892
718252007116	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
718252007117	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
718252007118	active site
718252007119	HIGH motif; other site
718252007120	KMSKS motif; other site
718252007121	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
718252007122	tRNA binding surface [nucleotide binding]; other site
718252007123	anticodon binding site; other site
718252007124	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
718252007125	dimer interface [polypeptide binding]; other site
718252007126	putative tRNA-binding site [nucleotide binding]; other site
718252007127	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
718252007128	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718252007129	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
718252007130	asparagine synthetase B; Provisional; Region: asnB; PRK09431
718252007131	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
718252007132	dimer interface [polypeptide binding]; other site
718252007133	active site
718252007134	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
718252007135	Ligand Binding Site [chemical binding]; other site
718252007136	Molecular Tunnel; other site
718252007137	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
718252007138	metal binding site 2 [ion binding]; metal-binding site
718252007139	putative DNA binding helix; other site
718252007140	metal binding site 1 [ion binding]; metal-binding site
718252007141	dimer interface [polypeptide binding]; other site
718252007142	structural Zn2+ binding site [ion binding]; other site
718252007143	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718252007144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718252007145	DNA-binding site [nucleotide binding]; DNA binding site
718252007146	FCD domain; Region: FCD; pfam07729
718252007147	TraX protein; Region: TraX; pfam05857
718252007148	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
718252007149	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
718252007150	active site
718252007151	trimer interface [polypeptide binding]; other site
718252007152	allosteric site; other site
718252007153	active site lid [active]
718252007154	hexamer (dimer of trimers) interface [polypeptide binding]; other site
718252007155	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718252007156	dimerization domain swap beta strand [polypeptide binding]; other site
718252007157	regulatory protein interface [polypeptide binding]; other site
718252007158	active site
718252007159	regulatory phosphorylation site [posttranslational modification]; other site
718252007160	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
718252007161	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
718252007162	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
718252007163	active site
718252007164	dimer interface [polypeptide binding]; other site
718252007165	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
718252007166	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
718252007167	dimer interface [polypeptide binding]; other site
718252007168	active site
718252007169	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
718252007170	putative active site [active]
718252007171	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718252007172	active pocket/dimerization site; other site
718252007173	active site
718252007174	phosphorylation site [posttranslational modification]
718252007175	Preprotein translocase subunit; Region: YajC; pfam02699
718252007176	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
718252007177	intersubunit interface [polypeptide binding]; other site
718252007178	active site
718252007179	zinc binding site [ion binding]; other site
718252007180	Na+ binding site [ion binding]; other site
718252007181	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718252007182	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718252007183	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718252007184	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718252007185	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252007186	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
718252007187	active site
718252007188	phosphorylation site [posttranslational modification]
718252007189	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
718252007190	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
718252007191	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
718252007192	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252007193	motif II; other site
718252007194	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
718252007195	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
718252007196	AAA ATPase domain; Region: AAA_16; pfam13191
718252007197	Archaeal ATPase; Region: Arch_ATPase; pfam01637
718252007198	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
718252007199	acetolactate synthase; Reviewed; Region: PRK08322
718252007200	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718252007201	PYR/PP interface [polypeptide binding]; other site
718252007202	dimer interface [polypeptide binding]; other site
718252007203	TPP binding site [chemical binding]; other site
718252007204	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718252007205	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
718252007206	TPP-binding site [chemical binding]; other site
718252007207	dimer interface [polypeptide binding]; other site
718252007208	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
718252007209	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
718252007210	active site
718252007211	catalytic residue [active]
718252007212	dimer interface [polypeptide binding]; other site
718252007213	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
718252007214	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718252007215	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718252007216	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
718252007217	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252007218	Walker A/P-loop; other site
718252007219	ATP binding site [chemical binding]; other site
718252007220	Q-loop/lid; other site
718252007221	ABC transporter signature motif; other site
718252007222	Walker B; other site
718252007223	D-loop; other site
718252007224	H-loop/switch region; other site
718252007225	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252007226	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
718252007227	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718252007228	Walker A/P-loop; other site
718252007229	ATP binding site [chemical binding]; other site
718252007230	Q-loop/lid; other site
718252007231	ABC transporter signature motif; other site
718252007232	Walker B; other site
718252007233	D-loop; other site
718252007234	H-loop/switch region; other site
718252007235	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718252007236	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
718252007237	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
718252007238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252007239	dimer interface [polypeptide binding]; other site
718252007240	conserved gate region; other site
718252007241	putative PBP binding loops; other site
718252007242	ABC-ATPase subunit interface; other site
718252007243	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
718252007244	peptide binding site [polypeptide binding]; other site
718252007245	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
718252007246	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
718252007247	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718252007248	phosphodiesterase; Provisional; Region: PRK12704
718252007249	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
718252007250	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718252007251	Zn2+ binding site [ion binding]; other site
718252007252	Mg2+ binding site [ion binding]; other site
718252007253	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252007254	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252007255	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252007256	dimerization interface [polypeptide binding]; other site
718252007257	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
718252007258	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
718252007259	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
718252007260	Chromate transporter; Region: Chromate_transp; pfam02417
718252007261	Chromate transporter; Region: Chromate_transp; pfam02417
718252007262	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
718252007263	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252007264	active site
718252007265	motif I; other site
718252007266	motif II; other site
718252007267	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718252007268	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
718252007269	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
718252007270	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
718252007271	active site
718252007272	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
718252007273	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
718252007274	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
718252007275	putative active site [active]
718252007276	nucleotide binding site [chemical binding]; other site
718252007277	nudix motif; other site
718252007278	putative metal binding site [ion binding]; other site
718252007279	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
718252007280	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
718252007281	putative sugar binding sites [chemical binding]; other site
718252007282	Q-X-W motif; other site
718252007283	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718252007284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252007285	Coenzyme A binding pocket [chemical binding]; other site
718252007286	Trp repressor protein; Region: Trp_repressor; cl17266
718252007287	DJ-1 family protein; Region: not_thiJ; TIGR01383
718252007288	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
718252007289	conserved cys residue [active]
718252007290	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
718252007291	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
718252007292	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
718252007293	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
718252007294	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
718252007295	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718252007296	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718252007297	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718252007298	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718252007299	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
718252007300	Walker A/P-loop; other site
718252007301	ATP binding site [chemical binding]; other site
718252007302	Q-loop/lid; other site
718252007303	ABC transporter signature motif; other site
718252007304	Walker B; other site
718252007305	D-loop; other site
718252007306	H-loop/switch region; other site
718252007307	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
718252007308	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718252007309	catalytic residue [active]
718252007310	hypothetical protein; Provisional; Region: PRK13690
718252007311	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
718252007312	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
718252007313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718252007314	active site
718252007315	phosphorylation site [posttranslational modification]
718252007316	intermolecular recognition site; other site
718252007317	dimerization interface [polypeptide binding]; other site
718252007318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718252007319	DNA binding site [nucleotide binding]
718252007320	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718252007321	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718252007322	dimerization interface [polypeptide binding]; other site
718252007323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718252007324	dimer interface [polypeptide binding]; other site
718252007325	phosphorylation site [posttranslational modification]
718252007326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718252007327	ATP binding site [chemical binding]; other site
718252007328	Mg2+ binding site [ion binding]; other site
718252007329	G-X-G motif; other site
718252007330	Sortase family; Region: Sortase; pfam04203
718252007331	active site
718252007332	catalytic site [active]
718252007333	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
718252007334	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
718252007335	active site
718252007336	catalytic site [active]
718252007337	T surface-antigen of pili; Region: FctA; pfam12892
718252007338	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
718252007339	nucleophilic elbow; other site
718252007340	catalytic triad; other site
718252007341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718252007342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718252007343	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718252007344	dimerization interface [polypeptide binding]; other site
718252007345	VanZ like family; Region: VanZ; cl01971
718252007346	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
718252007347	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
718252007348	active site
718252007349	substrate binding site [chemical binding]; other site
718252007350	metal binding site [ion binding]; metal-binding site
718252007351	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
718252007352	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718252007353	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
718252007354	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
718252007355	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718252007356	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
718252007357	putative NAD(P) binding site [chemical binding]; other site
718252007358	active site
718252007359	putative substrate binding site [chemical binding]; other site
718252007360	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
718252007361	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
718252007362	active site
718252007363	homodimer interface [polypeptide binding]; other site
718252007364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718252007365	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
718252007366	NAD(P) binding site [chemical binding]; other site
718252007367	active site
718252007368	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
718252007369	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
718252007370	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
718252007371	putative trimer interface [polypeptide binding]; other site
718252007372	putative CoA binding site [chemical binding]; other site
718252007373	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
718252007374	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
718252007375	NAD(P) binding site [chemical binding]; other site
718252007376	homodimer interface [polypeptide binding]; other site
718252007377	substrate binding site [chemical binding]; other site
718252007378	active site
718252007379	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
718252007380	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
718252007381	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
718252007382	trimer interface [polypeptide binding]; other site
718252007383	active site
718252007384	substrate binding site [chemical binding]; other site
718252007385	CoA binding site [chemical binding]; other site
718252007386	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718252007387	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u1; cd10925
718252007388	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
718252007389	NodB motif; other site
718252007390	putative active site [active]
718252007391	putative catalytic site [active]
718252007392	putative Zn binding site [ion binding]; other site
718252007393	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
718252007394	putative ADP-binding pocket [chemical binding]; other site
718252007395	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718252007396	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
718252007397	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718252007398	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
718252007399	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
718252007400	G3 box; other site
718252007401	Switch II region; other site
718252007402	G4 box; other site
718252007403	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
718252007404	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
718252007405	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718252007406	Int/Topo IB signature motif; other site
718252007407	Archaeal ATPase; Region: Arch_ATPase; pfam01637
718252007408	AAA ATPase domain; Region: AAA_16; pfam13191
718252007409	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718252007410	MarR family; Region: MarR_2; cl17246
718252007411	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
718252007412	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718252007413	active site
718252007414	Int/Topo IB signature motif; other site
718252007415	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252007416	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718252007417	Int/Topo IB signature motif; other site
718252007418	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
718252007419	active site
718252007420	NTP binding site [chemical binding]; other site
718252007421	metal binding triad [ion binding]; metal-binding site
718252007422	antibiotic binding site [chemical binding]; other site
718252007423	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
718252007424	Helix-turn-helix domain; Region: HTH_17; pfam12728
718252007425	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
718252007426	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
718252007427	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
718252007428	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
718252007429	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718252007430	catalytic core [active]
718252007431	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718252007432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718252007433	non-specific DNA binding site [nucleotide binding]; other site
718252007434	salt bridge; other site
718252007435	sequence-specific DNA binding site [nucleotide binding]; other site
718252007436	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718252007437	active site
718252007438	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
718252007439	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
718252007440	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252007441	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
718252007442	histidinol-phosphatase; Provisional; Region: PRK07328
718252007443	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
718252007444	active site
718252007445	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
718252007446	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
718252007447	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
718252007448	metal binding site [ion binding]; metal-binding site
718252007449	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
718252007450	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718252007451	catalytic residues [active]
718252007452	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718252007453	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
718252007454	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
718252007455	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718252007456	PYR/PP interface [polypeptide binding]; other site
718252007457	dimer interface [polypeptide binding]; other site
718252007458	TPP binding site [chemical binding]; other site
718252007459	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718252007460	transketolase; Reviewed; Region: PRK05899
718252007461	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
718252007462	TPP-binding site [chemical binding]; other site
718252007463	dimer interface [polypeptide binding]; other site
718252007464	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
718252007465	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718252007466	active site
718252007467	catalytic triad [active]
718252007468	oxyanion hole [active]
718252007469	serine/threonine transporter SstT; Provisional; Region: PRK13628
718252007470	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718252007471	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
718252007472	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
718252007473	active site
718252007474	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718252007475	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
718252007476	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718252007477	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718252007478	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
718252007479	PhoU domain; Region: PhoU; pfam01895
718252007480	PhoU domain; Region: PhoU; pfam01895
718252007481	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
718252007482	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
718252007483	Walker A/P-loop; other site
718252007484	ATP binding site [chemical binding]; other site
718252007485	Q-loop/lid; other site
718252007486	ABC transporter signature motif; other site
718252007487	Walker B; other site
718252007488	D-loop; other site
718252007489	H-loop/switch region; other site
718252007490	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
718252007491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252007492	dimer interface [polypeptide binding]; other site
718252007493	conserved gate region; other site
718252007494	putative PBP binding loops; other site
718252007495	ABC-ATPase subunit interface; other site
718252007496	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
718252007497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718252007498	dimer interface [polypeptide binding]; other site
718252007499	conserved gate region; other site
718252007500	putative PBP binding loops; other site
718252007501	ABC-ATPase subunit interface; other site
718252007502	PBP superfamily domain; Region: PBP_like_2; cl17296
718252007503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718252007504	Coenzyme A binding pocket [chemical binding]; other site
718252007505	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718252007506	active site turn [active]
718252007507	phosphorylation site [posttranslational modification]
718252007508	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
718252007509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718252007510	S-adenosylmethionine binding site [chemical binding]; other site
718252007511	RNA methyltransferase, RsmE family; Region: TIGR00046
718252007512	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
718252007513	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
718252007514	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
718252007515	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718252007516	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718252007517	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718252007518	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
718252007519	nucleophile elbow; other site
718252007520	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
718252007521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718252007522	motif II; other site
718252007523	LytTr DNA-binding domain; Region: LytTR; pfam04397
718252007524	putative glycosyl transferase; Provisional; Region: PRK10073
718252007525	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718252007526	active site
718252007527	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
718252007528	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
718252007529	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
718252007530	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
718252007531	active site
718252007532	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
718252007533	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
718252007534	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
718252007535	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
718252007536	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
718252007537	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
718252007538	ligand binding site [chemical binding]; other site
718252007539	flexible hinge region; other site
718252007540	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
718252007541	putative switch regulator; other site
718252007542	non-specific DNA interactions [nucleotide binding]; other site
718252007543	DNA binding site [nucleotide binding]
718252007544	sequence specific DNA binding site [nucleotide binding]; other site
718252007545	putative cAMP binding site [chemical binding]; other site
718252007546	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
718252007547	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718252007548	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
718252007549	active site
718252007550	homodimer interface [polypeptide binding]; other site
718252007551	AzlC protein; Region: AzlC; cl00570
718252007552	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718252007553	metal-binding site [ion binding]
718252007554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718252007555	dimerization interface [polypeptide binding]; other site
718252007556	putative DNA binding site [nucleotide binding]; other site
718252007557	putative Zn2+ binding site [ion binding]; other site
718252007558	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
718252007559	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
718252007560	active site 1 [active]
718252007561	active site 2 [active]
718252007562	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
718252007563	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
718252007564	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
718252007565	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
718252007566	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
718252007567	Int/Topo IB signature motif; other site