-- dump date 20140619_093209 -- class Genbank::misc_feature -- table misc_feature_note -- id note 381764000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 381764000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 381764000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764000004 Walker A motif; other site 381764000005 ATP binding site [chemical binding]; other site 381764000006 Walker B motif; other site 381764000007 arginine finger; other site 381764000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 381764000009 DnaA box-binding interface [nucleotide binding]; other site 381764000010 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 381764000011 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 381764000012 ligand binding site [chemical binding]; other site 381764000013 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 381764000014 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 381764000015 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 381764000016 Walker A/P-loop; other site 381764000017 ATP binding site [chemical binding]; other site 381764000018 Q-loop/lid; other site 381764000019 ABC transporter signature motif; other site 381764000020 Walker B; other site 381764000021 D-loop; other site 381764000022 H-loop/switch region; other site 381764000023 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 381764000024 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381764000025 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 381764000026 TM-ABC transporter signature motif; other site 381764000027 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381764000028 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 381764000029 TM-ABC transporter signature motif; other site 381764000030 Uncharacterized conserved protein [Function unknown]; Region: COG0432 381764000031 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 381764000032 IHF dimer interface [polypeptide binding]; other site 381764000033 IHF - DNA interface [nucleotide binding]; other site 381764000034 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 381764000035 GAF domain; Region: GAF_2; pfam13185 381764000036 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 381764000037 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764000038 Zn2+ binding site [ion binding]; other site 381764000039 Mg2+ binding site [ion binding]; other site 381764000040 FecR protein; Region: FecR; pfam04773 381764000041 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 381764000042 Mitotic-spindle organizing gamma-tubulin ring associated; Region: MOZART2; pfam12926 381764000043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 381764000044 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 381764000045 cyclase homology domain; Region: CHD; cd07302 381764000046 nucleotidyl binding site; other site 381764000047 metal binding site [ion binding]; metal-binding site 381764000048 dimer interface [polypeptide binding]; other site 381764000049 CHASE2 domain; Region: CHASE2; pfam05226 381764000050 Uncharacterized conserved protein [Function unknown]; Region: COG0432 381764000051 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 381764000052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764000053 putative active site [active] 381764000054 heme pocket [chemical binding]; other site 381764000055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764000056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764000057 Walker A motif; other site 381764000058 ATP binding site [chemical binding]; other site 381764000059 Walker B motif; other site 381764000060 arginine finger; other site 381764000061 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 381764000062 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 381764000063 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 381764000064 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 381764000065 Interdomain contacts; other site 381764000066 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 381764000067 Interdomain contacts; other site 381764000068 Cytokine receptor motif; other site 381764000069 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 381764000070 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 381764000071 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 381764000072 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 381764000073 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 381764000074 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 381764000075 SLBB domain; Region: SLBB; pfam10531 381764000076 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 381764000077 Chain length determinant protein; Region: Wzz; pfam02706 381764000078 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 381764000079 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381764000080 DNA-binding site [nucleotide binding]; DNA binding site 381764000081 RNA-binding motif; other site 381764000082 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 381764000083 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764000084 Integrase core domain; Region: rve; pfam00665 381764000085 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764000086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764000087 metal binding site [ion binding]; metal-binding site 381764000088 active site 381764000089 I-site; other site 381764000090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764000091 RNA binding surface [nucleotide binding]; other site 381764000092 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 381764000093 pseudouridine synthase; Region: TIGR00093 381764000094 active site 381764000095 Protein of unknown function (DUF445); Region: DUF445; pfam04286 381764000096 Uncharacterized conserved protein [Function unknown]; Region: COG1633 381764000097 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 381764000098 diiron binding motif [ion binding]; other site 381764000099 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 381764000100 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764000101 Integrase core domain; Region: rve; pfam00665 381764000102 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 381764000103 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 381764000104 active site 381764000105 multimer interface [polypeptide binding]; other site 381764000106 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 381764000107 Transglycosylase; Region: Transgly; pfam00912 381764000108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 381764000109 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 381764000110 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 381764000111 DNA binding site [nucleotide binding] 381764000112 active site 381764000113 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 381764000114 catalytic motif [active] 381764000115 Zn binding site [ion binding]; other site 381764000116 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 381764000117 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 381764000118 TPP-binding site [chemical binding]; other site 381764000119 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 381764000120 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 381764000121 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 381764000122 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 381764000123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764000124 active site 381764000125 phosphorylation site [posttranslational modification] 381764000126 intermolecular recognition site; other site 381764000127 dimerization interface [polypeptide binding]; other site 381764000128 CheB methylesterase; Region: CheB_methylest; pfam01339 381764000129 S-layer homology domain; Region: SLH; pfam00395 381764000130 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 381764000131 dimer interface [polypeptide binding]; other site 381764000132 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 381764000133 active site 381764000134 metal binding site [ion binding]; metal-binding site 381764000135 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381764000136 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 381764000137 TM-ABC transporter signature motif; other site 381764000138 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 381764000139 TM-ABC transporter signature motif; other site 381764000140 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 381764000141 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 381764000142 Walker A/P-loop; other site 381764000143 ATP binding site [chemical binding]; other site 381764000144 Q-loop/lid; other site 381764000145 ABC transporter signature motif; other site 381764000146 Walker B; other site 381764000147 D-loop; other site 381764000148 H-loop/switch region; other site 381764000149 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 381764000150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 381764000151 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 381764000152 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 381764000153 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 381764000154 dimer interface [polypeptide binding]; other site 381764000155 PYR/PP interface [polypeptide binding]; other site 381764000156 TPP binding site [chemical binding]; other site 381764000157 substrate binding site [chemical binding]; other site 381764000158 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 381764000159 TPP-binding site; other site 381764000160 4Fe-4S binding domain; Region: Fer4; pfam00037 381764000161 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 381764000162 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 381764000163 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 381764000164 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 381764000165 dimer interface [polypeptide binding]; other site 381764000166 PYR/PP interface [polypeptide binding]; other site 381764000167 TPP binding site [chemical binding]; other site 381764000168 substrate binding site [chemical binding]; other site 381764000169 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 381764000170 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 381764000171 TPP-binding site [chemical binding]; other site 381764000172 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 381764000173 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 381764000174 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 381764000175 catalytic triad [active] 381764000176 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 381764000177 putative FMN binding site [chemical binding]; other site 381764000178 Staphylococcal nuclease homologues; Region: SNc; smart00318 381764000179 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 381764000180 Catalytic site; other site 381764000181 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 381764000182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764000183 TPR motif; other site 381764000184 TPR repeat; Region: TPR_11; pfam13414 381764000185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764000186 TPR motif; other site 381764000187 binding surface 381764000188 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381764000189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764000190 aspartate aminotransferase; Provisional; Region: PRK07568 381764000191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381764000192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764000193 homodimer interface [polypeptide binding]; other site 381764000194 catalytic residue [active] 381764000195 HTH-like domain; Region: HTH_21; pfam13276 381764000196 Integrase core domain; Region: rve; pfam00665 381764000197 Integrase core domain; Region: rve_3; pfam13683 381764000198 Transposase; Region: HTH_Tnp_1; pfam01527 381764000199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381764000200 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764000201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 381764000202 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764000203 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764000204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764000205 metal binding site [ion binding]; metal-binding site 381764000206 active site 381764000207 I-site; other site 381764000208 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 381764000209 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 381764000210 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 381764000211 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 381764000212 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 381764000213 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 381764000214 dihydrodipicolinate synthase; Region: dapA; TIGR00674 381764000215 dimer interface [polypeptide binding]; other site 381764000216 active site 381764000217 catalytic residue [active] 381764000218 dihydrodipicolinate reductase; Provisional; Region: PRK00048 381764000219 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 381764000220 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 381764000221 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 381764000222 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 381764000223 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 381764000224 active site 381764000225 trimer interface [polypeptide binding]; other site 381764000226 substrate binding site [chemical binding]; other site 381764000227 CoA binding site [chemical binding]; other site 381764000228 aspartate kinase; Reviewed; Region: PRK06635 381764000229 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 381764000230 putative nucleotide binding site [chemical binding]; other site 381764000231 putative catalytic residues [active] 381764000232 putative Mg ion binding site [ion binding]; other site 381764000233 putative aspartate binding site [chemical binding]; other site 381764000234 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 381764000235 putative allosteric regulatory site; other site 381764000236 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 381764000237 putative allosteric regulatory residue; other site 381764000238 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 381764000239 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 381764000240 inhibitor-cofactor binding pocket; inhibition site 381764000241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764000242 catalytic residue [active] 381764000243 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 381764000244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 381764000245 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764000246 Integrase core domain; Region: rve; pfam00665 381764000247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381764000248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381764000249 catalytic residue [active] 381764000250 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 381764000251 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 381764000252 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 381764000253 metal binding site [ion binding]; metal-binding site 381764000254 dimer interface [polypeptide binding]; other site 381764000255 Starch binding domain; Region: CBM_2; smart01065 381764000256 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 381764000257 Putative esterase; Region: Esterase; pfam00756 381764000258 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 381764000259 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 381764000260 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 381764000261 dimer interface [polypeptide binding]; other site 381764000262 active site 381764000263 glycine-pyridoxal phosphate binding site [chemical binding]; other site 381764000264 folate binding site [chemical binding]; other site 381764000265 Uncharacterized conserved protein [Function unknown]; Region: COG4198 381764000266 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 381764000267 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 381764000268 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 381764000269 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 381764000270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 381764000271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 381764000272 nucleotide binding site [chemical binding]; other site 381764000273 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 381764000274 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 381764000275 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 381764000276 Walker A/P-loop; other site 381764000277 ATP binding site [chemical binding]; other site 381764000278 Q-loop/lid; other site 381764000279 ABC transporter signature motif; other site 381764000280 Walker B; other site 381764000281 D-loop; other site 381764000282 H-loop/switch region; other site 381764000283 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 381764000284 Response regulator receiver domain; Region: Response_reg; pfam00072 381764000285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764000286 active site 381764000287 phosphorylation site [posttranslational modification] 381764000288 intermolecular recognition site; other site 381764000289 dimerization interface [polypeptide binding]; other site 381764000290 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 381764000291 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381764000292 elongation factor P; Validated; Region: PRK00529 381764000293 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 381764000294 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 381764000295 RNA binding site [nucleotide binding]; other site 381764000296 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 381764000297 RNA binding site [nucleotide binding]; other site 381764000298 Asp23 family; Region: Asp23; pfam03780 381764000299 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 381764000300 putative RNA binding site [nucleotide binding]; other site 381764000301 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 381764000302 dihydropteroate synthase; Region: DHPS; TIGR01496 381764000303 substrate binding pocket [chemical binding]; other site 381764000304 dimer interface [polypeptide binding]; other site 381764000305 inhibitor binding site; inhibition site 381764000306 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 381764000307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764000308 RNA binding surface [nucleotide binding]; other site 381764000309 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 381764000310 active site 381764000311 uracil binding [chemical binding]; other site 381764000312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 381764000313 metal ion-dependent adhesion site (MIDAS); other site 381764000314 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 381764000315 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 381764000316 putative dimer interface [polypeptide binding]; other site 381764000317 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 381764000318 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 381764000319 putative ligand binding site [chemical binding]; other site 381764000320 NAD binding site [chemical binding]; other site 381764000321 dimerization interface [polypeptide binding]; other site 381764000322 catalytic site [active] 381764000323 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 381764000324 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 381764000325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381764000326 catalytic residue [active] 381764000327 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 381764000328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381764000329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764000330 homodimer interface [polypeptide binding]; other site 381764000331 catalytic residue [active] 381764000332 butyrate kinase; Provisional; Region: PRK03011 381764000333 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 381764000334 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 381764000335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 381764000336 nucleotide binding site [chemical binding]; other site 381764000337 Acetokinase family; Region: Acetate_kinase; cl17229 381764000338 antiporter inner membrane protein; Provisional; Region: PRK11670 381764000339 Ferredoxin [Energy production and conversion]; Region: COG1146 381764000340 4Fe-4S binding domain; Region: Fer4; cl02805 381764000341 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 381764000342 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 381764000343 dimer interface [polypeptide binding]; other site 381764000344 PYR/PP interface [polypeptide binding]; other site 381764000345 TPP binding site [chemical binding]; other site 381764000346 substrate binding site [chemical binding]; other site 381764000347 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 381764000348 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 381764000349 TPP-binding site [chemical binding]; other site 381764000350 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 381764000351 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 381764000352 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764000353 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 381764000354 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 381764000355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 381764000356 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 381764000357 active site 381764000358 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 381764000359 bacterial Hfq-like; Region: Hfq; cd01716 381764000360 hexamer interface [polypeptide binding]; other site 381764000361 Sm1 motif; other site 381764000362 RNA binding site [nucleotide binding]; other site 381764000363 Sm2 motif; other site 381764000364 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 381764000365 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 381764000366 HflX GTPase family; Region: HflX; cd01878 381764000367 G1 box; other site 381764000368 GTP/Mg2+ binding site [chemical binding]; other site 381764000369 Switch I region; other site 381764000370 G2 box; other site 381764000371 G3 box; other site 381764000372 Switch II region; other site 381764000373 G4 box; other site 381764000374 G5 box; other site 381764000375 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 381764000376 Peptidase family M23; Region: Peptidase_M23; pfam01551 381764000377 S-adenosylmethionine synthetase; Validated; Region: PRK05250 381764000378 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 381764000379 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 381764000380 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 381764000381 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 381764000382 Cache domain; Region: Cache_1; pfam02743 381764000383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 381764000384 dimerization interface [polypeptide binding]; other site 381764000385 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381764000386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764000387 dimer interface [polypeptide binding]; other site 381764000388 putative CheW interface [polypeptide binding]; other site 381764000389 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 381764000390 active sites [active] 381764000391 tetramer interface [polypeptide binding]; other site 381764000392 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 381764000393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 381764000394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764000395 Coenzyme A binding pocket [chemical binding]; other site 381764000396 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 381764000397 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 381764000398 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 381764000399 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 381764000400 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 381764000401 active site 381764000402 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 381764000403 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 381764000404 homodimer interface [polypeptide binding]; other site 381764000405 oligonucleotide binding site [chemical binding]; other site 381764000406 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 381764000407 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 381764000408 homotetramer interface [polypeptide binding]; other site 381764000409 ligand binding site [chemical binding]; other site 381764000410 catalytic site [active] 381764000411 NAD binding site [chemical binding]; other site 381764000412 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 381764000413 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 381764000414 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 381764000415 Walker A motif; other site 381764000416 ATP binding site [chemical binding]; other site 381764000417 Walker B motif; other site 381764000418 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 381764000419 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 381764000420 nucleotide binding site [chemical binding]; other site 381764000421 SulA interaction site; other site 381764000422 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 381764000423 Cell division protein FtsA; Region: FtsA; smart00842 381764000424 Cell division protein FtsA; Region: FtsA; pfam14450 381764000425 Uncharacterized conserved protein [Function unknown]; Region: COG1262 381764000426 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 381764000427 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 381764000428 protein binding site [polypeptide binding]; other site 381764000429 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 381764000430 ADP-ribose binding site [chemical binding]; other site 381764000431 recombination factor protein RarA; Reviewed; Region: PRK13342 381764000432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764000433 Walker A motif; other site 381764000434 ATP binding site [chemical binding]; other site 381764000435 Walker B motif; other site 381764000436 arginine finger; other site 381764000437 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 381764000438 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 381764000439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381764000440 NAD(P) binding site [chemical binding]; other site 381764000441 active site 381764000442 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 381764000443 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 381764000444 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 381764000445 Fe-S cluster binding site [ion binding]; other site 381764000446 active site 381764000447 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381764000448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381764000449 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 381764000450 Walker A/P-loop; other site 381764000451 ATP binding site [chemical binding]; other site 381764000452 Q-loop/lid; other site 381764000453 ABC transporter signature motif; other site 381764000454 Walker B; other site 381764000455 D-loop; other site 381764000456 H-loop/switch region; other site 381764000457 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381764000458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381764000459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764000460 Walker A/P-loop; other site 381764000461 ATP binding site [chemical binding]; other site 381764000462 Q-loop/lid; other site 381764000463 ABC transporter signature motif; other site 381764000464 Walker B; other site 381764000465 D-loop; other site 381764000466 H-loop/switch region; other site 381764000467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381764000468 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 381764000469 non-specific DNA interactions [nucleotide binding]; other site 381764000470 DNA binding site [nucleotide binding] 381764000471 sequence specific DNA binding site [nucleotide binding]; other site 381764000472 putative cAMP binding site [chemical binding]; other site 381764000473 MarR family; Region: MarR_2; cl17246 381764000474 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 381764000475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764000476 Walker A motif; other site 381764000477 ATP binding site [chemical binding]; other site 381764000478 Walker B motif; other site 381764000479 arginine finger; other site 381764000480 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 381764000481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 381764000482 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381764000483 catalytic residue [active] 381764000484 YGGT family; Region: YGGT; pfam02325 381764000485 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: pnk; PRK14075 381764000486 ATP-NAD kinase; Region: NAD_kinase; pfam01513 381764000487 PhoU domain; Region: PhoU; pfam01895 381764000488 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 381764000489 PhoU domain; Region: PhoU; pfam01895 381764000490 Predicted permeases [General function prediction only]; Region: COG0795 381764000491 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 381764000492 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 381764000493 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 381764000494 Ligand Binding Site [chemical binding]; other site 381764000495 TilS substrate C-terminal domain; Region: TilS_C; smart00977 381764000496 FtsH Extracellular; Region: FtsH_ext; pfam06480 381764000497 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 381764000498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764000499 Walker A motif; other site 381764000500 ATP binding site [chemical binding]; other site 381764000501 Walker B motif; other site 381764000502 arginine finger; other site 381764000503 Peptidase family M41; Region: Peptidase_M41; pfam01434 381764000504 Predicted thioesterase [General function prediction only]; Region: COG5496 381764000505 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 381764000506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764000507 FeS/SAM binding site; other site 381764000508 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 381764000509 RNA methyltransferase, RsmE family; Region: TIGR00046 381764000510 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 381764000511 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 381764000512 Walker A/P-loop; other site 381764000513 ATP binding site [chemical binding]; other site 381764000514 Q-loop/lid; other site 381764000515 ABC transporter signature motif; other site 381764000516 Walker B; other site 381764000517 D-loop; other site 381764000518 H-loop/switch region; other site 381764000519 TOBE domain; Region: TOBE; pfam03459 381764000520 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 381764000521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764000522 Radical SAM superfamily; Region: Radical_SAM; pfam04055 381764000523 FeS/SAM binding site; other site 381764000524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381764000525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381764000526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764000527 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 381764000528 RNA binding site [nucleotide binding]; other site 381764000529 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 381764000530 Heme NO binding; Region: HNOB; pfam07700 381764000531 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381764000532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764000533 dimer interface [polypeptide binding]; other site 381764000534 putative CheW interface [polypeptide binding]; other site 381764000535 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 381764000536 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 381764000537 active site 381764000538 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 381764000539 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 381764000540 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 381764000541 inhibitor-cofactor binding pocket; inhibition site 381764000542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764000543 catalytic residue [active] 381764000544 hypothetical protein; Reviewed; Region: PRK00024 381764000545 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 381764000546 MPN+ (JAMM) motif; other site 381764000547 Zinc-binding site [ion binding]; other site 381764000548 Maf-like protein; Region: Maf; pfam02545 381764000549 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 381764000550 active site 381764000551 dimer interface [polypeptide binding]; other site 381764000552 Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977 381764000553 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 381764000554 Nucleoside recognition; Region: Gate; pfam07670 381764000555 ribonuclease R; Region: RNase_R; TIGR02063 381764000556 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 381764000557 RNB domain; Region: RNB; pfam00773 381764000558 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 381764000559 RNA binding site [nucleotide binding]; other site 381764000560 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 381764000561 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 381764000562 nucleotide binding pocket [chemical binding]; other site 381764000563 K-X-D-G motif; other site 381764000564 catalytic site [active] 381764000565 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 381764000566 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 381764000567 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 381764000568 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 381764000569 Dimer interface [polypeptide binding]; other site 381764000570 BRCT sequence motif; other site 381764000571 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 381764000572 substrate binding site; other site 381764000573 dimer interface; other site 381764000574 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 381764000575 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 381764000576 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381764000577 active site 381764000578 metal binding site [ion binding]; metal-binding site 381764000579 homotetramer interface [polypeptide binding]; other site 381764000580 comF family protein; Region: comF; TIGR00201 381764000581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764000582 active site 381764000583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381764000584 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 381764000585 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 381764000586 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381764000587 Walker A/P-loop; other site 381764000588 ATP binding site [chemical binding]; other site 381764000589 Q-loop/lid; other site 381764000590 ABC transporter signature motif; other site 381764000591 Walker B; other site 381764000592 D-loop; other site 381764000593 H-loop/switch region; other site 381764000594 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 381764000595 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 381764000596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381764000597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381764000598 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 381764000599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764000600 Walker A/P-loop; other site 381764000601 ATP binding site [chemical binding]; other site 381764000602 Q-loop/lid; other site 381764000603 ABC transporter signature motif; other site 381764000604 Walker B; other site 381764000605 D-loop; other site 381764000606 H-loop/switch region; other site 381764000607 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764000608 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 381764000609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764000610 Walker A/P-loop; other site 381764000611 ATP binding site [chemical binding]; other site 381764000612 Q-loop/lid; other site 381764000613 ABC transporter signature motif; other site 381764000614 Walker B; other site 381764000615 D-loop; other site 381764000616 H-loop/switch region; other site 381764000617 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764000618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 381764000619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764000620 dimer interface [polypeptide binding]; other site 381764000621 conserved gate region; other site 381764000622 putative PBP binding loops; other site 381764000623 ABC-ATPase subunit interface; other site 381764000624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 381764000625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764000626 dimer interface [polypeptide binding]; other site 381764000627 conserved gate region; other site 381764000628 putative PBP binding loops; other site 381764000629 ABC-ATPase subunit interface; other site 381764000630 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 381764000631 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 381764000632 GIY-YIG motif/motif A; other site 381764000633 active site 381764000634 catalytic site [active] 381764000635 putative DNA binding site [nucleotide binding]; other site 381764000636 metal binding site [ion binding]; metal-binding site 381764000637 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 381764000638 CTP synthetase; Validated; Region: pyrG; PRK05380 381764000639 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 381764000640 Catalytic site [active] 381764000641 active site 381764000642 UTP binding site [chemical binding]; other site 381764000643 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 381764000644 active site 381764000645 putative oxyanion hole; other site 381764000646 catalytic triad [active] 381764000647 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 381764000648 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 381764000649 active site 381764000650 elongation factor Ts; Reviewed; Region: tsf; PRK12332 381764000651 UBA/TS-N domain; Region: UBA; pfam00627 381764000652 Elongation factor TS; Region: EF_TS; pfam00889 381764000653 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 381764000654 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 381764000655 B12 binding site [chemical binding]; other site 381764000656 cobalt ligand [ion binding]; other site 381764000657 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 381764000658 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 381764000659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764000660 Walker A/P-loop; other site 381764000661 ATP binding site [chemical binding]; other site 381764000662 Q-loop/lid; other site 381764000663 ABC transporter signature motif; other site 381764000664 Walker B; other site 381764000665 D-loop; other site 381764000666 H-loop/switch region; other site 381764000667 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 381764000668 dimer interaction site [polypeptide binding]; other site 381764000669 substrate-binding tunnel; other site 381764000670 active site 381764000671 catalytic site [active] 381764000672 substrate binding site [chemical binding]; other site 381764000673 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 381764000674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764000675 FeS/SAM binding site; other site 381764000676 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 381764000677 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 381764000678 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 381764000679 NAD(P) binding site [chemical binding]; other site 381764000680 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 381764000681 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 381764000682 active site 2 [active] 381764000683 active site 1 [active] 381764000684 Coenzyme A transferase; Region: CoA_trans; cl17247 381764000685 Coenzyme A transferase; Region: CoA_trans; cl17247 381764000686 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 381764000687 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 381764000688 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 381764000689 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381764000690 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 381764000691 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 381764000692 active site 381764000693 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 381764000694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381764000695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764000696 homodimer interface [polypeptide binding]; other site 381764000697 catalytic residue [active] 381764000698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764000699 Coenzyme A binding pocket [chemical binding]; other site 381764000700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764000701 PAS domain; Region: PAS_9; pfam13426 381764000702 putative active site [active] 381764000703 heme pocket [chemical binding]; other site 381764000704 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381764000705 GMP synthase; Reviewed; Region: guaA; PRK00074 381764000706 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 381764000707 AMP/PPi binding site [chemical binding]; other site 381764000708 candidate oxyanion hole; other site 381764000709 catalytic triad [active] 381764000710 potential glutamine specificity residues [chemical binding]; other site 381764000711 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 381764000712 ATP Binding subdomain [chemical binding]; other site 381764000713 Ligand Binding sites [chemical binding]; other site 381764000714 Dimerization subdomain; other site 381764000715 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 381764000716 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381764000717 active site 381764000718 homodimer interface [polypeptide binding]; other site 381764000719 catalytic site [active] 381764000720 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 381764000721 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 381764000722 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 381764000723 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 381764000724 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 381764000725 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 381764000726 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 381764000727 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 381764000728 CoA binding domain; Region: CoA_binding; smart00881 381764000729 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381764000730 catalytic loop [active] 381764000731 iron binding site [ion binding]; other site 381764000732 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 381764000733 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 381764000734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381764000735 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 381764000736 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 381764000737 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 381764000738 [2Fe-2S] cluster binding site [ion binding]; other site 381764000739 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 381764000740 dimer interface [polypeptide binding]; other site 381764000741 [2Fe-2S] cluster binding site [ion binding]; other site 381764000742 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 381764000743 SLBB domain; Region: SLBB; pfam10531 381764000744 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 381764000745 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 381764000746 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 381764000747 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 381764000748 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 381764000749 putative dimer interface [polypeptide binding]; other site 381764000750 [2Fe-2S] cluster binding site [ion binding]; other site 381764000751 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 381764000752 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 381764000753 Ligand binding site; other site 381764000754 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 381764000755 active site 381764000756 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 381764000757 homodimer interface [polypeptide binding]; other site 381764000758 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 381764000759 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764000760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381764000761 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381764000762 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 381764000763 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 381764000764 RNA polymerase factor sigma-70; Validated; Region: PRK08295 381764000765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381764000766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764000767 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 381764000768 active site 381764000769 motif I; other site 381764000770 motif II; other site 381764000771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764000772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764000773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 381764000774 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764000775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 381764000776 catalytic loop [active] 381764000777 iron binding site [ion binding]; other site 381764000778 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 381764000779 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 381764000780 4Fe-4S binding domain; Region: Fer4; pfam00037 381764000781 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 381764000782 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 381764000783 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 381764000784 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 381764000785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764000786 FeS/SAM binding site; other site 381764000787 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 381764000788 biotin synthase; Provisional; Region: PRK07094 381764000789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764000790 FeS/SAM binding site; other site 381764000791 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 381764000792 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 381764000793 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 381764000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381764000795 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 381764000796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764000797 Walker A/P-loop; other site 381764000798 ATP binding site [chemical binding]; other site 381764000799 Q-loop/lid; other site 381764000800 ABC transporter signature motif; other site 381764000801 Walker B; other site 381764000802 D-loop; other site 381764000803 H-loop/switch region; other site 381764000804 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 381764000805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 381764000806 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 381764000807 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 381764000808 G1 box; other site 381764000809 GTP/Mg2+ binding site [chemical binding]; other site 381764000810 Switch I region; other site 381764000811 G2 box; other site 381764000812 Switch II region; other site 381764000813 G3 box; other site 381764000814 G4 box; other site 381764000815 G5 box; other site 381764000816 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 381764000817 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 381764000818 tetramer interface [polypeptide binding]; other site 381764000819 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 381764000820 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 381764000821 Mg++ binding site [ion binding]; other site 381764000822 putative catalytic motif [active] 381764000823 putative substrate binding site [chemical binding]; other site 381764000824 Predicted membrane protein [Function unknown]; Region: COG3462 381764000825 Short C-terminal domain; Region: SHOCT; pfam09851 381764000826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764000827 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 381764000829 Putative glucoamylase; Region: Glycoamylase; pfam10091 381764000830 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 381764000831 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 381764000832 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381764000833 Walker A/P-loop; other site 381764000834 ATP binding site [chemical binding]; other site 381764000835 Q-loop/lid; other site 381764000836 ABC transporter signature motif; other site 381764000837 Walker B; other site 381764000838 D-loop; other site 381764000839 H-loop/switch region; other site 381764000840 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 381764000841 Cytokine receptor motif; other site 381764000842 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 381764000843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 381764000844 ABC-ATPase subunit interface; other site 381764000845 dimer interface [polypeptide binding]; other site 381764000846 putative PBP binding regions; other site 381764000847 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 381764000848 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 381764000849 intersubunit interface [polypeptide binding]; other site 381764000850 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 381764000851 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 381764000852 G1 box; other site 381764000853 GTP/Mg2+ binding site [chemical binding]; other site 381764000854 Switch I region; other site 381764000855 G2 box; other site 381764000856 G3 box; other site 381764000857 Switch II region; other site 381764000858 G4 box; other site 381764000859 G5 box; other site 381764000860 Nucleoside recognition; Region: Gate; pfam07670 381764000861 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 381764000862 Nucleoside recognition; Region: Gate; pfam07670 381764000863 FeoA domain; Region: FeoA; pfam04023 381764000864 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 381764000865 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 381764000866 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381764000867 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 381764000868 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 381764000869 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 381764000870 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 381764000871 dimer interface [polypeptide binding]; other site 381764000872 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 381764000873 active site 381764000874 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381764000875 substrate binding site [chemical binding]; other site 381764000876 catalytic residue [active] 381764000877 purine nucleoside phosphorylase; Provisional; Region: PRK08202 381764000878 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 381764000879 DHH family; Region: DHH; pfam01368 381764000880 DHHA1 domain; Region: DHHA1; pfam02272 381764000881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764000882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764000883 metal binding site [ion binding]; metal-binding site 381764000884 active site 381764000885 I-site; other site 381764000886 AAA ATPase domain; Region: AAA_16; pfam13191 381764000887 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764000888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764000889 metal binding site [ion binding]; metal-binding site 381764000890 active site 381764000891 I-site; other site 381764000892 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14653 381764000893 FAD binding domain; Region: FAD_binding_4; pfam01565 381764000894 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 381764000895 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 381764000896 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 381764000897 oligomer interface [polypeptide binding]; other site 381764000898 putative active site [active] 381764000899 metal binding site [ion binding]; metal-binding site 381764000900 Transcriptional regulators [Transcription]; Region: MarR; COG1846 381764000901 MarR family; Region: MarR; pfam01047 381764000902 PEGA domain; Region: PEGA; pfam08308 381764000903 S-layer homology domain; Region: SLH; pfam00395 381764000904 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 381764000905 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 381764000906 active site 381764000907 nucleophile elbow; other site 381764000908 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 381764000909 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 381764000910 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 381764000911 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14962 381764000912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764000913 Walker A motif; other site 381764000914 ATP binding site [chemical binding]; other site 381764000915 Walker B motif; other site 381764000916 arginine finger; other site 381764000917 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 381764000918 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 381764000919 Walker A motif; other site 381764000920 ATP binding site [chemical binding]; other site 381764000921 Walker B motif; other site 381764000922 PCRF domain; Region: PCRF; pfam03462 381764000923 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 381764000924 RF-1 domain; Region: RF-1; pfam00472 381764000925 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764000926 active site 381764000927 transcription termination factor Rho; Provisional; Region: rho; PRK09376 381764000928 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 381764000929 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 381764000930 RNA binding site [nucleotide binding]; other site 381764000931 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 381764000932 multimer interface [polypeptide binding]; other site 381764000933 Walker A motif; other site 381764000934 ATP binding site [chemical binding]; other site 381764000935 Walker B motif; other site 381764000936 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 381764000937 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 381764000938 FAD binding pocket [chemical binding]; other site 381764000939 FAD binding motif [chemical binding]; other site 381764000940 phosphate binding motif [ion binding]; other site 381764000941 beta-alpha-beta structure motif; other site 381764000942 NAD binding pocket [chemical binding]; other site 381764000943 Iron coordination center [ion binding]; other site 381764000944 putative oxidoreductase; Provisional; Region: PRK12831 381764000945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764000946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381764000947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381764000948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381764000949 DNA binding site [nucleotide binding] 381764000950 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 381764000951 dimerization interface [polypeptide binding]; other site 381764000952 ligand binding site [chemical binding]; other site 381764000953 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 381764000954 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 381764000955 active site 381764000956 catalytic residues [active] 381764000957 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 381764000958 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 381764000959 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 381764000960 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764000961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764000962 dimer interface [polypeptide binding]; other site 381764000963 conserved gate region; other site 381764000964 ABC-ATPase subunit interface; other site 381764000965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764000966 dimer interface [polypeptide binding]; other site 381764000967 conserved gate region; other site 381764000968 putative PBP binding loops; other site 381764000969 ABC-ATPase subunit interface; other site 381764000970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764000971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 381764000972 binding surface 381764000973 TPR motif; other site 381764000974 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 381764000975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764000976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764000977 dimer interface [polypeptide binding]; other site 381764000978 conserved gate region; other site 381764000979 ABC-ATPase subunit interface; other site 381764000980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764000981 dimer interface [polypeptide binding]; other site 381764000982 conserved gate region; other site 381764000983 putative PBP binding loops; other site 381764000984 ABC-ATPase subunit interface; other site 381764000985 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 381764000986 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381764000987 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381764000988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381764000989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381764000990 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 381764000991 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 381764000992 Cell division protein FtsA; Region: FtsA; smart00842 381764000993 Cell division protein FtsA; Region: FtsA; pfam14450 381764000994 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 381764000995 MutS domain III; Region: MutS_III; pfam05192 381764000996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764000997 Walker A/P-loop; other site 381764000998 ATP binding site [chemical binding]; other site 381764000999 Q-loop/lid; other site 381764001000 ABC transporter signature motif; other site 381764001001 Walker B; other site 381764001002 D-loop; other site 381764001003 H-loop/switch region; other site 381764001004 Smr domain; Region: Smr; pfam01713 381764001005 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 381764001006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 381764001007 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 381764001008 metal ion-dependent adhesion site (MIDAS); other site 381764001009 Bacitracin resistance protein BacA; Region: BacA; pfam02673 381764001010 Protein of unknown function (DUF327); Region: DUF327; pfam03885 381764001011 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 381764001012 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 381764001013 ADP-glucose phosphorylase; Region: PLN02643 381764001014 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 381764001015 dimer interface [polypeptide binding]; other site 381764001016 active site 381764001017 glycogen synthase; Provisional; Region: glgA; PRK00654 381764001018 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 381764001019 ADP-binding pocket [chemical binding]; other site 381764001020 homodimer interface [polypeptide binding]; other site 381764001021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381764001022 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 381764001023 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 381764001024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764001025 putative substrate translocation pore; other site 381764001026 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 381764001027 Clp amino terminal domain; Region: Clp_N; pfam02861 381764001028 Clp amino terminal domain; Region: Clp_N; pfam02861 381764001029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001030 Walker A motif; other site 381764001031 ATP binding site [chemical binding]; other site 381764001032 Walker B motif; other site 381764001033 arginine finger; other site 381764001034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001035 Walker A motif; other site 381764001036 ATP binding site [chemical binding]; other site 381764001037 Walker B motif; other site 381764001038 arginine finger; other site 381764001039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 381764001040 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381764001041 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 381764001042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381764001043 substrate binding pocket [chemical binding]; other site 381764001044 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381764001045 membrane-bound complex binding site; other site 381764001046 hinge residues; other site 381764001047 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 381764001048 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 381764001049 NAD(P) binding site [chemical binding]; other site 381764001050 homotetramer interface [polypeptide binding]; other site 381764001051 homodimer interface [polypeptide binding]; other site 381764001052 active site 381764001053 putative acyltransferase; Provisional; Region: PRK05790 381764001054 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 381764001055 dimer interface [polypeptide binding]; other site 381764001056 active site 381764001057 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 381764001058 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764001059 Integrase core domain; Region: rve; pfam00665 381764001060 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 381764001061 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 381764001062 substrate binding pocket [chemical binding]; other site 381764001063 chain length determination region; other site 381764001064 substrate-Mg2+ binding site; other site 381764001065 catalytic residues [active] 381764001066 aspartate-rich region 1; other site 381764001067 active site lid residues [active] 381764001068 aspartate-rich region 2; other site 381764001069 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381764001070 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 381764001071 4Fe-4S binding domain; Region: Fer4; pfam00037 381764001072 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 381764001073 Predicted Fe-S protein [General function prediction only]; Region: COG2000 381764001074 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 381764001075 dimer interface [polypeptide binding]; other site 381764001076 [2Fe-2S] cluster binding site [ion binding]; other site 381764001077 Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482 381764001078 30S subunit binding site; other site 381764001079 EDD domain protein, DegV family; Region: DegV; TIGR00762 381764001080 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 381764001081 EDD domain protein, DegV family; Region: DegV; TIGR00762 381764001082 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 381764001083 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 381764001084 gamma subunit interface [polypeptide binding]; other site 381764001085 epsilon subunit interface [polypeptide binding]; other site 381764001086 LBP interface [polypeptide binding]; other site 381764001087 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 381764001088 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 381764001089 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 381764001090 alpha subunit interaction interface [polypeptide binding]; other site 381764001091 Walker A motif; other site 381764001092 ATP binding site [chemical binding]; other site 381764001093 Walker B motif; other site 381764001094 inhibitor binding site; inhibition site 381764001095 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 381764001096 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 381764001097 core domain interface [polypeptide binding]; other site 381764001098 delta subunit interface [polypeptide binding]; other site 381764001099 epsilon subunit interface [polypeptide binding]; other site 381764001100 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 381764001101 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 381764001102 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 381764001103 beta subunit interaction interface [polypeptide binding]; other site 381764001104 Walker A motif; other site 381764001105 ATP binding site [chemical binding]; other site 381764001106 Walker B motif; other site 381764001107 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 381764001108 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13441 381764001109 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 381764001110 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 381764001111 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 381764001112 F0F1 ATP synthase subunit C; Provisional; Region: PRK13471 381764001113 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 381764001114 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 381764001115 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 381764001116 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 381764001117 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 381764001118 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 381764001119 active site 381764001120 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 381764001121 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 381764001122 DHH family; Region: DHH; pfam01368 381764001123 DHHA1 domain; Region: DHHA1; pfam02272 381764001124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 381764001125 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764001126 Integrase core domain; Region: rve; pfam00665 381764001127 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381764001128 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 381764001129 Amidohydrolase; Region: Amidohydro_4; pfam13147 381764001130 active site 381764001131 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 381764001132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381764001133 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 381764001134 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 381764001135 TRAM domain; Region: TRAM; cl01282 381764001136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764001137 S-adenosylmethionine binding site [chemical binding]; other site 381764001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764001139 putative substrate translocation pore; other site 381764001140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764001141 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764001142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764001143 metal binding site [ion binding]; metal-binding site 381764001144 active site 381764001145 I-site; other site 381764001146 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 381764001147 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 381764001148 active site 381764001149 HIGH motif; other site 381764001150 nucleotide binding site [chemical binding]; other site 381764001151 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 381764001152 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 381764001153 active site 381764001154 KMSKS motif; other site 381764001155 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 381764001156 tRNA binding surface [nucleotide binding]; other site 381764001157 anticodon binding site; other site 381764001158 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 381764001159 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 381764001160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381764001161 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 381764001162 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 381764001163 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 381764001164 active site 381764001165 putative substrate binding pocket [chemical binding]; other site 381764001166 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 381764001167 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381764001168 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 381764001169 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 381764001170 Active_site [active] 381764001171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764001172 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764001173 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 381764001174 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 381764001175 transmembrane helices; other site 381764001176 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 381764001177 Citrate transporter; Region: CitMHS; pfam03600 381764001178 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 381764001179 transmembrane helices; other site 381764001180 TPR repeat; Region: TPR_11; pfam13414 381764001181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 381764001182 binding surface 381764001183 TPR motif; other site 381764001184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381764001185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764001186 dimer interface [polypeptide binding]; other site 381764001187 putative CheW interface [polypeptide binding]; other site 381764001188 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 381764001189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381764001190 Chromate transporter; Region: Chromate_transp; pfam02417 381764001191 Chromate transporter; Region: Chromate_transp; pfam02417 381764001192 EamA-like transporter family; Region: EamA; cl17759 381764001193 EamA-like transporter family; Region: EamA; pfam00892 381764001194 DNA polymerase I; Provisional; Region: PRK05755 381764001195 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 381764001196 active site 381764001197 metal binding site 1 [ion binding]; metal-binding site 381764001198 putative 5' ssDNA interaction site; other site 381764001199 metal binding site 3; metal-binding site 381764001200 metal binding site 2 [ion binding]; metal-binding site 381764001201 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 381764001202 putative DNA binding site [nucleotide binding]; other site 381764001203 putative metal binding site [ion binding]; other site 381764001204 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 381764001205 active site 381764001206 catalytic site [active] 381764001207 substrate binding site [chemical binding]; other site 381764001208 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 381764001209 active site 381764001210 DNA binding site [nucleotide binding] 381764001211 catalytic site [active] 381764001212 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 381764001213 EDD domain protein, DegV family; Region: DegV; TIGR00762 381764001214 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 381764001215 DNA repair protein RadA; Provisional; Region: PRK11823 381764001216 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 381764001217 Walker A motif; other site 381764001218 ATP binding site [chemical binding]; other site 381764001219 Walker B motif; other site 381764001220 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 381764001221 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 381764001222 Clp amino terminal domain; Region: Clp_N; pfam02861 381764001223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001224 Walker A motif; other site 381764001225 ATP binding site [chemical binding]; other site 381764001226 Walker B motif; other site 381764001227 arginine finger; other site 381764001228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001229 Walker A motif; other site 381764001230 ATP binding site [chemical binding]; other site 381764001231 Walker B motif; other site 381764001232 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 381764001233 PHP domain; Region: PHP; pfam02811 381764001234 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 381764001235 active site 381764001236 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 381764001237 GTPase CgtA; Reviewed; Region: obgE; PRK12297 381764001238 GTP1/OBG; Region: GTP1_OBG; pfam01018 381764001239 Obg GTPase; Region: Obg; cd01898 381764001240 G1 box; other site 381764001241 GTP/Mg2+ binding site [chemical binding]; other site 381764001242 Switch I region; other site 381764001243 G2 box; other site 381764001244 G3 box; other site 381764001245 Switch II region; other site 381764001246 G4 box; other site 381764001247 G5 box; other site 381764001248 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 381764001249 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 381764001250 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 381764001251 active site 381764001252 (T/H)XGH motif; other site 381764001253 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 381764001254 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 381764001255 FMN binding site [chemical binding]; other site 381764001256 active site 381764001257 catalytic residues [active] 381764001258 substrate binding site [chemical binding]; other site 381764001259 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 381764001260 catalytic core [active] 381764001261 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381764001262 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 381764001263 Walker A/P-loop; other site 381764001264 ATP binding site [chemical binding]; other site 381764001265 Q-loop/lid; other site 381764001266 ABC transporter signature motif; other site 381764001267 Walker B; other site 381764001268 D-loop; other site 381764001269 H-loop/switch region; other site 381764001270 TOBE domain; Region: TOBE_2; pfam08402 381764001271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001272 dimer interface [polypeptide binding]; other site 381764001273 conserved gate region; other site 381764001274 putative PBP binding loops; other site 381764001275 ABC-ATPase subunit interface; other site 381764001276 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381764001277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001278 dimer interface [polypeptide binding]; other site 381764001279 conserved gate region; other site 381764001280 putative PBP binding loops; other site 381764001281 ABC-ATPase subunit interface; other site 381764001282 purine nucleoside phosphorylase; Provisional; Region: PRK08202 381764001283 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 381764001284 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 381764001285 trmE is a tRNA modification GTPase; Region: trmE; cd04164 381764001286 G1 box; other site 381764001287 GTP/Mg2+ binding site [chemical binding]; other site 381764001288 Switch I region; other site 381764001289 G2 box; other site 381764001290 Switch II region; other site 381764001291 G3 box; other site 381764001292 G4 box; other site 381764001293 G5 box; other site 381764001294 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 381764001295 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 381764001296 FHIPEP family; Region: FHIPEP; pfam00771 381764001297 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 381764001298 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381764001299 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 381764001300 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 381764001301 P-loop; other site 381764001302 PilZ domain; Region: PilZ; pfam07238 381764001303 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 381764001304 Flagellar protein YcgR; Region: YcgR_2; pfam12945 381764001305 PilZ domain; Region: PilZ; pfam07238 381764001306 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 381764001307 CheC-like family; Region: CheC; pfam04509 381764001308 CheC-like family; Region: CheC; pfam04509 381764001309 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13495 381764001310 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 381764001311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381764001312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381764001313 DNA binding residues [nucleotide binding] 381764001314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 381764001315 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764001316 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 381764001317 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 381764001318 SLBB domain; Region: SLBB; pfam10531 381764001319 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381764001320 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 381764001321 FMN-binding domain; Region: FMN_bind; cl01081 381764001322 electron transport complex RsxE subunit; Provisional; Region: PRK12405 381764001323 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 381764001324 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 381764001325 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 381764001326 RNase E interface [polypeptide binding]; other site 381764001327 trimer interface [polypeptide binding]; other site 381764001328 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 381764001329 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 381764001330 RNase E interface [polypeptide binding]; other site 381764001331 trimer interface [polypeptide binding]; other site 381764001332 active site 381764001333 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 381764001334 putative nucleic acid binding region [nucleotide binding]; other site 381764001335 G-X-X-G motif; other site 381764001336 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 381764001337 RNA binding site [nucleotide binding]; other site 381764001338 domain interface; other site 381764001339 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 381764001340 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 381764001341 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 381764001342 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 381764001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001344 Walker A motif; other site 381764001345 ATP binding site [chemical binding]; other site 381764001346 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 381764001347 Walker B motif; other site 381764001348 arginine finger; other site 381764001349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 381764001350 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 381764001351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001352 dimer interface [polypeptide binding]; other site 381764001353 conserved gate region; other site 381764001354 putative PBP binding loops; other site 381764001355 ABC-ATPase subunit interface; other site 381764001356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764001357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001358 dimer interface [polypeptide binding]; other site 381764001359 conserved gate region; other site 381764001360 putative PBP binding loops; other site 381764001361 ABC-ATPase subunit interface; other site 381764001362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764001363 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 381764001364 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 381764001365 active site 381764001366 Riboflavin kinase; Region: Flavokinase; smart00904 381764001367 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 381764001368 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 381764001369 minor groove reading motif; other site 381764001370 helix-hairpin-helix signature motif; other site 381764001371 substrate binding pocket [chemical binding]; other site 381764001372 active site 381764001373 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 381764001374 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 381764001375 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 381764001376 FlaG protein; Region: FlaG; pfam03646 381764001377 Ribosome-binding factor A; Region: RBFA; pfam02033 381764001378 HDOD domain; Region: HDOD; pfam08668 381764001379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764001380 Zn2+ binding site [ion binding]; other site 381764001381 Mg2+ binding site [ion binding]; other site 381764001382 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381764001383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381764001384 dimer interface [polypeptide binding]; other site 381764001385 phosphorylation site [posttranslational modification] 381764001386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764001387 ATP binding site [chemical binding]; other site 381764001388 Mg2+ binding site [ion binding]; other site 381764001389 G-X-G motif; other site 381764001390 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 381764001391 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 381764001392 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 381764001393 active site 381764001394 HIGH motif; other site 381764001395 KMSK motif region; other site 381764001396 tRNA binding surface [nucleotide binding]; other site 381764001397 DALR anticodon binding domain; Region: DALR_1; smart00836 381764001398 anticodon binding site; other site 381764001399 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 381764001400 G1 box; other site 381764001401 GTP/Mg2+ binding site [chemical binding]; other site 381764001402 Switch I region; other site 381764001403 G2 box; other site 381764001404 G3 box; other site 381764001405 Switch II region; other site 381764001406 G4 box; other site 381764001407 G5 box; other site 381764001408 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 381764001409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001410 Walker A motif; other site 381764001411 ATP binding site [chemical binding]; other site 381764001412 Walker B motif; other site 381764001413 arginine finger; other site 381764001414 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 381764001415 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 381764001416 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381764001417 glycerol kinase; Provisional; Region: glpK; PRK00047 381764001418 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 381764001419 N- and C-terminal domain interface [polypeptide binding]; other site 381764001420 active site 381764001421 MgATP binding site [chemical binding]; other site 381764001422 catalytic site [active] 381764001423 metal binding site [ion binding]; metal-binding site 381764001424 glycerol binding site [chemical binding]; other site 381764001425 homotetramer interface [polypeptide binding]; other site 381764001426 homodimer interface [polypeptide binding]; other site 381764001427 protein IIAGlc interface [polypeptide binding]; other site 381764001428 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 381764001429 DNA polymerase III subunit delta'; Validated; Region: PRK08485 381764001430 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 381764001431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764001432 motif II; other site 381764001433 Protein of unknown function DUF45; Region: DUF45; pfam01863 381764001434 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 381764001435 intersubunit interface [polypeptide binding]; other site 381764001436 active site 381764001437 Zn2+ binding site [ion binding]; other site 381764001438 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 381764001439 galactokinase; Provisional; Region: PRK03817 381764001440 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 381764001441 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 381764001442 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 381764001443 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 381764001444 dimer interface [polypeptide binding]; other site 381764001445 active site 381764001446 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 381764001447 Melibiase; Region: Melibiase; pfam02065 381764001448 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381764001449 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381764001450 DNA binding site [nucleotide binding] 381764001451 domain linker motif; other site 381764001452 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 381764001453 dimerization interface [polypeptide binding]; other site 381764001454 ligand binding site [chemical binding]; other site 381764001455 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 381764001456 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 381764001457 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 381764001458 H+ Antiporter protein; Region: 2A0121; TIGR00900 381764001459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764001460 putative substrate translocation pore; other site 381764001461 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 381764001462 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 381764001463 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 381764001464 active site 381764001465 dimer interface [polypeptide binding]; other site 381764001466 effector binding site; other site 381764001467 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 381764001468 TSCPD domain; Region: TSCPD; pfam12637 381764001469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 381764001470 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764001471 Integrase core domain; Region: rve; pfam00665 381764001472 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 381764001473 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 381764001474 CoA binding domain; Region: CoA_binding; smart00881 381764001475 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 381764001476 diaminopimelate decarboxylase; Region: lysA; TIGR01048 381764001477 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 381764001478 active site 381764001479 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381764001480 substrate binding site [chemical binding]; other site 381764001481 catalytic residues [active] 381764001482 dimer interface [polypeptide binding]; other site 381764001483 hypothetical protein; Provisional; Region: PRK00967 381764001484 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 381764001485 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 381764001486 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381764001487 Walker A/P-loop; other site 381764001488 ATP binding site [chemical binding]; other site 381764001489 Q-loop/lid; other site 381764001490 ABC transporter signature motif; other site 381764001491 Walker B; other site 381764001492 D-loop; other site 381764001493 H-loop/switch region; other site 381764001494 Predicted transcriptional regulators [Transcription]; Region: COG1725 381764001495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381764001496 DNA-binding site [nucleotide binding]; DNA binding site 381764001497 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 381764001498 FtsX-like permease family; Region: FtsX; pfam02687 381764001499 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 381764001500 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 381764001501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381764001502 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 381764001503 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381764001504 DNA binding residues [nucleotide binding] 381764001505 DNA primase; Validated; Region: dnaG; PRK05667 381764001506 CHC2 zinc finger; Region: zf-CHC2; pfam01807 381764001507 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 381764001508 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 381764001509 active site 381764001510 metal binding site [ion binding]; metal-binding site 381764001511 interdomain interaction site; other site 381764001512 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 381764001513 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 381764001514 23S rRNA interface [nucleotide binding]; other site 381764001515 L3 interface [polypeptide binding]; other site 381764001516 Predicted membrane protein [Function unknown]; Region: COG3601 381764001517 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 381764001518 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 381764001519 Protein of unknown function (DUF464); Region: DUF464; pfam04327 381764001520 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 381764001521 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 381764001522 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 381764001523 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 381764001524 Mg++ binding site [ion binding]; other site 381764001525 putative catalytic motif [active] 381764001526 substrate binding site [chemical binding]; other site 381764001527 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 381764001528 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 381764001529 Mg++ binding site [ion binding]; other site 381764001530 putative catalytic motif [active] 381764001531 putative substrate binding site [chemical binding]; other site 381764001532 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 381764001533 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381764001534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381764001535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381764001536 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 381764001537 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381764001538 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381764001539 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381764001540 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 381764001541 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 381764001542 putative ADP-binding pocket [chemical binding]; other site 381764001543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 381764001544 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 381764001545 substrate binding site [chemical binding]; other site 381764001546 ATP binding site [chemical binding]; other site 381764001547 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764001548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001549 dimer interface [polypeptide binding]; other site 381764001550 conserved gate region; other site 381764001551 putative PBP binding loops; other site 381764001552 ABC-ATPase subunit interface; other site 381764001553 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 381764001554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001555 dimer interface [polypeptide binding]; other site 381764001556 conserved gate region; other site 381764001557 putative PBP binding loops; other site 381764001558 ABC-ATPase subunit interface; other site 381764001559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381764001560 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381764001561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001562 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 381764001563 MarR family; Region: MarR_2; pfam12802 381764001564 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 381764001565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 381764001566 nucleotide binding site [chemical binding]; other site 381764001567 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 381764001568 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 381764001569 ATP-binding site [chemical binding]; other site 381764001570 Sugar specificity; other site 381764001571 Pyrimidine base specificity; other site 381764001572 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14330 381764001573 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 381764001574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764001575 FeS/SAM binding site; other site 381764001576 TRAM domain; Region: TRAM; pfam01938 381764001577 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 381764001578 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 381764001579 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 381764001580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764001581 active site 381764001582 motif I; other site 381764001583 motif II; other site 381764001584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 381764001585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764001586 active site 381764001587 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 381764001588 active site 381764001589 dimer interface [polypeptide binding]; other site 381764001590 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 381764001591 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 381764001592 phosphate binding site [ion binding]; other site 381764001593 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 381764001594 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 381764001595 FAD binding pocket [chemical binding]; other site 381764001596 FAD binding motif [chemical binding]; other site 381764001597 phosphate binding motif [ion binding]; other site 381764001598 beta-alpha-beta structure motif; other site 381764001599 NAD binding pocket [chemical binding]; other site 381764001600 Iron coordination center [ion binding]; other site 381764001601 dihydroorotase; Validated; Region: pyrC; PRK09357 381764001602 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381764001603 active site 381764001604 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 381764001605 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 381764001606 dimer interface [polypeptide binding]; other site 381764001607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764001608 catalytic residue [active] 381764001609 serine O-acetyltransferase; Region: cysE; TIGR01172 381764001610 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 381764001611 trimer interface [polypeptide binding]; other site 381764001612 active site 381764001613 substrate binding site [chemical binding]; other site 381764001614 CoA binding site [chemical binding]; other site 381764001615 ferric uptake regulator; Provisional; Region: fur; PRK09462 381764001616 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 381764001617 metal binding site 2 [ion binding]; metal-binding site 381764001618 putative DNA binding helix; other site 381764001619 metal binding site 1 [ion binding]; metal-binding site 381764001620 dimer interface [polypeptide binding]; other site 381764001621 structural Zn2+ binding site [ion binding]; other site 381764001622 Rubrerythrin [Energy production and conversion]; Region: COG1592 381764001623 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 381764001624 binuclear metal center [ion binding]; other site 381764001625 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 381764001626 iron binding site [ion binding]; other site 381764001627 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 381764001628 non-heme iron binding site [ion binding]; other site 381764001629 tetramer interface [polypeptide binding]; other site 381764001630 Protein of unknown function (DUF554); Region: DUF554; pfam04474 381764001631 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 381764001632 Malic enzyme, N-terminal domain; Region: malic; pfam00390 381764001633 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 381764001634 putative NAD(P) binding site [chemical binding]; other site 381764001635 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764001636 PAS domain; Region: PAS_9; pfam13426 381764001637 putative active site [active] 381764001638 heme pocket [chemical binding]; other site 381764001639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764001640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764001641 metal binding site [ion binding]; metal-binding site 381764001642 active site 381764001643 I-site; other site 381764001644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 381764001645 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 381764001646 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 381764001647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764001648 FeS assembly ATPase SufC; Region: sufC; TIGR01978 381764001649 Walker A/P-loop; other site 381764001650 ATP binding site [chemical binding]; other site 381764001651 Q-loop/lid; other site 381764001652 ABC transporter signature motif; other site 381764001653 Walker B; other site 381764001654 D-loop; other site 381764001655 H-loop/switch region; other site 381764001656 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 381764001657 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 381764001658 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 381764001659 transmembrane helices; other site 381764001660 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 381764001661 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 381764001662 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 381764001663 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 381764001664 Isochorismatase family; Region: Isochorismatase; pfam00857 381764001665 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 381764001666 catalytic triad [active] 381764001667 conserved cis-peptide bond; other site 381764001668 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 381764001669 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 381764001670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764001671 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 381764001672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381764001673 active site 381764001674 metal binding site [ion binding]; metal-binding site 381764001675 homotetramer interface [polypeptide binding]; other site 381764001676 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 381764001677 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 381764001678 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 381764001679 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 381764001680 active site 381764001681 substrate binding site [chemical binding]; other site 381764001682 metal binding site [ion binding]; metal-binding site 381764001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001684 dimer interface [polypeptide binding]; other site 381764001685 conserved gate region; other site 381764001686 putative PBP binding loops; other site 381764001687 ABC-ATPase subunit interface; other site 381764001688 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 381764001689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764001690 dimer interface [polypeptide binding]; other site 381764001691 conserved gate region; other site 381764001692 putative PBP binding loops; other site 381764001693 ABC-ATPase subunit interface; other site 381764001694 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 381764001695 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 381764001696 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 381764001697 putative active site [active] 381764001698 excinuclease ABC subunit B; Provisional; Region: PRK05298 381764001699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764001700 ATP binding site [chemical binding]; other site 381764001701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764001702 nucleotide binding region [chemical binding]; other site 381764001703 ATP-binding site [chemical binding]; other site 381764001704 Ultra-violet resistance protein B; Region: UvrB; pfam12344 381764001705 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 381764001706 Domain of unknown function (DUF814); Region: DUF814; pfam05670 381764001707 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 381764001708 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 381764001709 putative ligand binding site [chemical binding]; other site 381764001710 NAD binding site [chemical binding]; other site 381764001711 dimer interface [polypeptide binding]; other site 381764001712 putative catalytic site [active] 381764001713 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381764001714 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381764001715 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 381764001716 Peptidase family C69; Region: Peptidase_C69; cl17793 381764001717 DEAD-like helicases superfamily; Region: DEXDc; smart00487 381764001718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764001719 ATP binding site [chemical binding]; other site 381764001720 putative Mg++ binding site [ion binding]; other site 381764001721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764001722 nucleotide binding region [chemical binding]; other site 381764001723 ATP-binding site [chemical binding]; other site 381764001724 DNA protecting protein DprA; Region: dprA; TIGR00732 381764001725 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 381764001726 putative active site [active] 381764001727 catalytic site [active] 381764001728 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 381764001729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764001730 ATP binding site [chemical binding]; other site 381764001731 putative Mg++ binding site [ion binding]; other site 381764001732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764001733 nucleotide binding region [chemical binding]; other site 381764001734 ATP-binding site [chemical binding]; other site 381764001735 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 381764001736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764001737 Walker A/P-loop; other site 381764001738 ATP binding site [chemical binding]; other site 381764001739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764001740 ABC transporter signature motif; other site 381764001741 Walker B; other site 381764001742 D-loop; other site 381764001743 H-loop/switch region; other site 381764001744 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 381764001745 DNA methylase; Region: N6_N4_Mtase; pfam01555 381764001746 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 381764001747 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 381764001748 DEAD-like helicases superfamily; Region: DEXDc; smart00487 381764001749 Protein of unknown function DUF45; Region: DUF45; pfam01863 381764001750 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 381764001751 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 381764001752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764001753 ATP binding site [chemical binding]; other site 381764001754 putative Mg++ binding site [ion binding]; other site 381764001755 Protein of unknown function DUF86; Region: DUF86; cl01031 381764001756 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 381764001757 active site 381764001758 NTP binding site [chemical binding]; other site 381764001759 metal binding triad [ion binding]; metal-binding site 381764001760 antibiotic binding site [chemical binding]; other site 381764001761 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 381764001762 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 381764001763 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 381764001764 HsdM N-terminal domain; Region: HsdM_N; pfam12161 381764001765 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 381764001766 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 381764001767 Methyltransferase domain; Region: Methyltransf_26; pfam13659 381764001768 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764001769 Integrase core domain; Region: rve; pfam00665 381764001770 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 381764001771 SeqA protein; Region: SeqA; cl11470 381764001772 CrcB-like protein; Region: CRCB; cl09114 381764001773 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 381764001774 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381764001775 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 381764001776 O-Antigen ligase; Region: Wzy_C; pfam04932 381764001777 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 381764001778 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 381764001779 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 381764001780 Mg++ binding site [ion binding]; other site 381764001781 putative catalytic motif [active] 381764001782 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 381764001783 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 381764001784 Part of AAA domain; Region: AAA_19; pfam13245 381764001785 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 381764001786 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 381764001787 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 381764001788 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 381764001789 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 381764001790 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 381764001791 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 381764001792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381764001793 NAD(P) binding site [chemical binding]; other site 381764001794 active site 381764001795 Y-family of DNA polymerases; Region: PolY; cl12025 381764001796 RNase_H superfamily; Region: RNase_H_2; pfam13482 381764001797 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 381764001798 DNA methylase; Region: N6_N4_Mtase; pfam01555 381764001799 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 381764001800 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 381764001801 TM-ABC transporter signature motif; other site 381764001802 PGAP1-like protein; Region: PGAP1; pfam07819 381764001803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381764001804 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381764001805 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 381764001806 TM-ABC transporter signature motif; other site 381764001807 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 381764001808 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 381764001809 Walker A/P-loop; other site 381764001810 ATP binding site [chemical binding]; other site 381764001811 Q-loop/lid; other site 381764001812 ABC transporter signature motif; other site 381764001813 Walker B; other site 381764001814 D-loop; other site 381764001815 H-loop/switch region; other site 381764001816 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 381764001817 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 381764001818 Walker A/P-loop; other site 381764001819 ATP binding site [chemical binding]; other site 381764001820 Q-loop/lid; other site 381764001821 ABC transporter signature motif; other site 381764001822 Walker B; other site 381764001823 D-loop; other site 381764001824 H-loop/switch region; other site 381764001825 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 381764001826 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 381764001827 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 381764001828 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 381764001829 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 381764001830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381764001831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381764001832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 381764001833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 381764001834 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 381764001835 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 381764001836 dimer interface [polypeptide binding]; other site 381764001837 active site 381764001838 CoA binding pocket [chemical binding]; other site 381764001839 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 381764001840 FMN binding site [chemical binding]; other site 381764001841 dimer interface [polypeptide binding]; other site 381764001842 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 381764001843 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 381764001844 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381764001845 Walker A/P-loop; other site 381764001846 ATP binding site [chemical binding]; other site 381764001847 Q-loop/lid; other site 381764001848 ABC transporter signature motif; other site 381764001849 Walker B; other site 381764001850 D-loop; other site 381764001851 H-loop/switch region; other site 381764001852 Predicted transcriptional regulators [Transcription]; Region: COG1725 381764001853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 381764001854 DNA-binding site [nucleotide binding]; DNA binding site 381764001855 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 381764001856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764001857 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381764001858 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 381764001859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764001860 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381764001861 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 381764001862 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 381764001863 putative NAD(P) binding site [chemical binding]; other site 381764001864 active site 381764001865 SnoaL-like domain; Region: SnoaL_2; pfam12680 381764001866 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 381764001867 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 381764001868 [2Fe-2S] cluster binding site [ion binding]; other site 381764001869 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 381764001870 hydrophobic ligand binding site; other site 381764001871 membrane protein; Provisional; Region: PRK14404 381764001872 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764001873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 381764001874 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764001875 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 381764001876 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 381764001877 Ligand binding site; other site 381764001878 Putative Catalytic site; other site 381764001879 DXD motif; other site 381764001880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764001881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764001882 putative substrate translocation pore; other site 381764001883 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 381764001884 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 381764001885 active site 381764001886 catalytic triad [active] 381764001887 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 381764001888 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 381764001889 putative N- and C-terminal domain interface [polypeptide binding]; other site 381764001890 putative active site [active] 381764001891 MgATP binding site [chemical binding]; other site 381764001892 catalytic site [active] 381764001893 metal binding site [ion binding]; metal-binding site 381764001894 putative carbohydrate binding site [chemical binding]; other site 381764001895 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764001896 Integrase core domain; Region: rve; pfam00665 381764001897 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 381764001898 Active site serine [active] 381764001899 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 381764001900 RNA/DNA hybrid binding site [nucleotide binding]; other site 381764001901 active site 381764001902 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 381764001903 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 381764001904 Substrate binding site; other site 381764001905 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001906 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 381764001907 putative ADP-binding pocket [chemical binding]; other site 381764001908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001909 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 381764001910 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 381764001911 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 381764001912 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 381764001913 putative ADP-binding pocket [chemical binding]; other site 381764001914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381764001915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001916 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 381764001917 active site 381764001918 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 381764001919 homodimer interface [polypeptide binding]; other site 381764001920 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 381764001921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001922 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381764001923 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001924 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 381764001925 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 381764001926 Type III secretion needle MxiH like; Region: MxiH; cl09641 381764001927 Bacterial sugar transferase; Region: Bac_transf; pfam02397 381764001928 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 381764001929 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 381764001930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001931 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 381764001932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764001933 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 381764001934 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 381764001935 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 381764001936 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 381764001937 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 381764001938 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 381764001939 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 381764001940 Ligand binding site [chemical binding]; other site 381764001941 Electron transfer flavoprotein domain; Region: ETF; pfam01012 381764001942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 381764001943 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 381764001944 FAD binding site [chemical binding]; other site 381764001945 homotetramer interface [polypeptide binding]; other site 381764001946 substrate binding pocket [chemical binding]; other site 381764001947 catalytic base [active] 381764001948 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 381764001949 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381764001950 active site 381764001951 homodimer interface [polypeptide binding]; other site 381764001952 catalytic site [active] 381764001953 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 381764001954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381764001955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381764001956 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 381764001957 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 381764001958 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 381764001959 active site 381764001960 Zn binding site [ion binding]; other site 381764001961 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 381764001962 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 381764001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764001964 Walker A motif; other site 381764001965 ATP binding site [chemical binding]; other site 381764001966 Walker B motif; other site 381764001967 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 381764001968 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 381764001969 putative active site [active] 381764001970 putative CoA binding site [chemical binding]; other site 381764001971 nudix motif; other site 381764001972 metal binding site [ion binding]; metal-binding site 381764001973 YWTD domain; Region: YWTD; pfam13570 381764001974 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 381764001975 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 381764001976 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 381764001977 putative RNA binding site [nucleotide binding]; other site 381764001978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764001979 S-adenosylmethionine binding site [chemical binding]; other site 381764001980 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 381764001981 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381764001982 Response regulator receiver domain; Region: Response_reg; pfam00072 381764001983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764001984 active site 381764001985 phosphorylation site [posttranslational modification] 381764001986 intermolecular recognition site; other site 381764001987 dimerization interface [polypeptide binding]; other site 381764001988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764001989 metal binding site [ion binding]; metal-binding site 381764001990 active site 381764001991 I-site; other site 381764001992 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 381764001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764001994 H+ Antiporter protein; Region: 2A0121; TIGR00900 381764001995 putative substrate translocation pore; other site 381764001996 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 381764001997 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 381764001998 oligomer interface [polypeptide binding]; other site 381764001999 active site 381764002000 metal binding site [ion binding]; metal-binding site 381764002001 hypothetical protein; Provisional; Region: PRK10621 381764002002 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381764002003 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 381764002004 putative active site [active] 381764002005 catalytic residue [active] 381764002006 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 381764002007 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 381764002008 5S rRNA interface [nucleotide binding]; other site 381764002009 CTC domain interface [polypeptide binding]; other site 381764002010 L16 interface [polypeptide binding]; other site 381764002011 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 381764002012 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 381764002013 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764002014 active site 381764002015 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14357 381764002016 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 381764002017 Substrate binding site; other site 381764002018 Mg++ binding site; other site 381764002019 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 381764002020 active site 381764002021 substrate binding site [chemical binding]; other site 381764002022 CoA binding site [chemical binding]; other site 381764002023 pyruvate phosphate dikinase; Provisional; Region: PRK09279 381764002024 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 381764002025 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 381764002026 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 381764002027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 381764002028 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 381764002029 TAP-like protein; Region: Abhydrolase_4; pfam08386 381764002030 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 381764002031 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 381764002032 NAD(P) binding site [chemical binding]; other site 381764002033 homotetramer interface [polypeptide binding]; other site 381764002034 homodimer interface [polypeptide binding]; other site 381764002035 active site 381764002036 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 381764002037 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 381764002038 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 381764002039 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 381764002040 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 381764002041 FMN binding site [chemical binding]; other site 381764002042 substrate binding site [chemical binding]; other site 381764002043 putative catalytic residue [active] 381764002044 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 381764002045 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 381764002046 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 381764002047 dimer interface [polypeptide binding]; other site 381764002048 active site 381764002049 EDD domain protein, DegV family; Region: DegV; TIGR00762 381764002050 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 381764002051 acyl carrier protein; Provisional; Region: acpP; PRK00982 381764002052 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 381764002053 Glycerophosphodiester phosphodiesterase domain of Thermotoga maritime and similar proteins; Region: GDPD_TmGDE_like; cd08568 381764002054 putative active site [active] 381764002055 catalytic site [active] 381764002056 putative metal binding site [ion binding]; other site 381764002057 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 381764002058 ligand binding site [chemical binding]; other site 381764002059 Tetratricopeptide repeat; Region: TPR_16; pfam13432 381764002060 putative GTP cyclohydrolase; Provisional; Region: PRK13674 381764002061 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 381764002062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764002063 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381764002064 Coenzyme A binding pocket [chemical binding]; other site 381764002065 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 381764002066 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 381764002067 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 381764002068 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 381764002069 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381764002070 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381764002071 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 381764002072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764002073 dimer interface [polypeptide binding]; other site 381764002074 conserved gate region; other site 381764002075 putative PBP binding loops; other site 381764002076 ABC-ATPase subunit interface; other site 381764002077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764002078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764002079 dimer interface [polypeptide binding]; other site 381764002080 conserved gate region; other site 381764002081 putative PBP binding loops; other site 381764002082 ABC-ATPase subunit interface; other site 381764002083 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 381764002084 FMN-binding domain; Region: FMN_bind; cl01081 381764002085 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 381764002086 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 381764002087 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 381764002088 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 381764002089 FAD binding pocket [chemical binding]; other site 381764002090 conserved FAD binding motif [chemical binding]; other site 381764002091 phosphate binding motif [ion binding]; other site 381764002092 beta-alpha-beta structure motif; other site 381764002093 NAD binding pocket [chemical binding]; other site 381764002094 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 381764002095 metal-dependent hydrolase; Provisional; Region: PRK00685 381764002096 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 381764002097 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 381764002098 ATP binding site [chemical binding]; other site 381764002099 Mg++ binding site [ion binding]; other site 381764002100 motif III; other site 381764002101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764002102 nucleotide binding region [chemical binding]; other site 381764002103 ATP-binding site [chemical binding]; other site 381764002104 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 381764002105 RNA binding site [nucleotide binding]; other site 381764002106 Isochorismatase family; Region: Isochorismatase; pfam00857 381764002107 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 381764002108 catalytic triad [active] 381764002109 conserved cis-peptide bond; other site 381764002110 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 381764002111 HTH domain; Region: HTH_11; pfam08279 381764002112 3H domain; Region: 3H; pfam02829 381764002113 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 381764002114 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 381764002115 active site 381764002116 metal binding site [ion binding]; metal-binding site 381764002117 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 381764002118 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 381764002119 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 381764002120 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 381764002121 NodB motif; other site 381764002122 putative active site [active] 381764002123 putative catalytic site [active] 381764002124 putative Zn binding site [ion binding]; other site 381764002125 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 381764002126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764002127 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 381764002128 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 381764002129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764002130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764002131 putative substrate translocation pore; other site 381764002132 signal recognition particle protein; Provisional; Region: PRK10867 381764002133 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 381764002134 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 381764002135 P loop; other site 381764002136 GTP binding site [chemical binding]; other site 381764002137 Signal peptide binding domain; Region: SRP_SPB; pfam02978 381764002138 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14524 381764002139 KH domain; Region: KH_4; pfam13083 381764002140 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 381764002141 RimM N-terminal domain; Region: RimM; pfam01782 381764002142 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 381764002143 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 381764002144 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 381764002145 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 381764002146 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 381764002147 Catalytic site [active] 381764002148 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 381764002149 FOG: CBS domain [General function prediction only]; Region: COG0517 381764002150 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 381764002151 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 381764002152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764002153 ATP binding site [chemical binding]; other site 381764002154 Mg2+ binding site [ion binding]; other site 381764002155 G-X-G motif; other site 381764002156 CoA binding domain; Region: CoA_binding_2; pfam13380 381764002157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 381764002158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764002159 Zn2+ binding site [ion binding]; other site 381764002160 Mg2+ binding site [ion binding]; other site 381764002161 translation initiation factor IF-3; Region: infC; TIGR00168 381764002162 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 381764002163 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 381764002164 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 381764002165 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 381764002166 23S rRNA binding site [nucleotide binding]; other site 381764002167 L21 binding site [polypeptide binding]; other site 381764002168 L13 binding site [polypeptide binding]; other site 381764002169 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 381764002170 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 381764002171 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 381764002172 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 381764002173 inhibitor-cofactor binding pocket; inhibition site 381764002174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764002175 catalytic residue [active] 381764002176 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 381764002177 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 381764002178 putative active site [active] 381764002179 catalytic triad [active] 381764002180 putative dimer interface [polypeptide binding]; other site 381764002181 replicative DNA helicase; Region: DnaB; TIGR00665 381764002182 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 381764002183 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 381764002184 Walker A motif; other site 381764002185 ATP binding site [chemical binding]; other site 381764002186 Walker B motif; other site 381764002187 DNA binding loops [nucleotide binding] 381764002188 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 381764002189 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 381764002190 active site 381764002191 (T/H)XGH motif; other site 381764002192 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 381764002193 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 381764002194 Walker A/P-loop; other site 381764002195 ATP binding site [chemical binding]; other site 381764002196 Q-loop/lid; other site 381764002197 ABC transporter signature motif; other site 381764002198 Walker B; other site 381764002199 D-loop; other site 381764002200 H-loop/switch region; other site 381764002201 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 381764002202 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 381764002203 GTPase Era; Reviewed; Region: era; PRK00089 381764002204 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 381764002205 G1 box; other site 381764002206 GTP/Mg2+ binding site [chemical binding]; other site 381764002207 Switch I region; other site 381764002208 G2 box; other site 381764002209 Switch II region; other site 381764002210 G3 box; other site 381764002211 G4 box; other site 381764002212 G5 box; other site 381764002213 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 381764002214 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 381764002215 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 381764002216 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 381764002217 dimer interface [polypeptide binding]; other site 381764002218 ssDNA binding site [nucleotide binding]; other site 381764002219 tetramer (dimer of dimers) interface [polypeptide binding]; other site 381764002220 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 381764002221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764002222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764002223 putative substrate translocation pore; other site 381764002224 Rubredoxin [Energy production and conversion]; Region: COG1773 381764002225 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 381764002226 iron binding site [ion binding]; other site 381764002227 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 381764002228 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 381764002229 active site 381764002230 HIGH motif; other site 381764002231 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 381764002232 active site 381764002233 KMSKS motif; other site 381764002234 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 381764002235 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 381764002236 active site 381764002237 HIGH motif; other site 381764002238 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 381764002239 KMSKS motif; other site 381764002240 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 381764002241 tRNA binding surface [nucleotide binding]; other site 381764002242 anticodon binding site; other site 381764002243 prolyl-tRNA synthetase; Provisional; Region: PRK09194 381764002244 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 381764002245 dimer interface [polypeptide binding]; other site 381764002246 motif 1; other site 381764002247 active site 381764002248 motif 2; other site 381764002249 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 381764002250 putative deacylase active site [active] 381764002251 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 381764002252 active site 381764002253 motif 3; other site 381764002254 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 381764002255 anticodon binding site; other site 381764002256 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 381764002257 hypothetical protein; Reviewed; Region: PRK09588 381764002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764002259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764002260 putative substrate translocation pore; other site 381764002261 AAA domain; Region: AAA_30; pfam13604 381764002262 AAA domain; Region: AAA_11; pfam13086 381764002263 Family description; Region: UvrD_C_2; pfam13538 381764002264 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 381764002265 RNA/DNA hybrid binding site [nucleotide binding]; other site 381764002266 active site 381764002267 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 381764002268 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 381764002269 dimer interface [polypeptide binding]; other site 381764002270 active site 381764002271 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381764002272 catalytic residues [active] 381764002273 substrate binding site [chemical binding]; other site 381764002274 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764002275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764002276 metal binding site [ion binding]; metal-binding site 381764002277 active site 381764002278 I-site; other site 381764002279 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14586 381764002280 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 381764002281 dimerization interface 3.5A [polypeptide binding]; other site 381764002282 active site 381764002283 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 381764002284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764002285 RNA binding surface [nucleotide binding]; other site 381764002286 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 381764002287 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381764002288 putative binding surface; other site 381764002289 active site 381764002290 P2 response regulator binding domain; Region: P2; pfam07194 381764002291 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 381764002292 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 381764002293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764002294 ATP binding site [chemical binding]; other site 381764002295 Mg2+ binding site [ion binding]; other site 381764002296 G-X-G motif; other site 381764002297 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 381764002298 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 381764002299 Response regulator receiver domain; Region: Response_reg; pfam00072 381764002300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764002301 active site 381764002302 phosphorylation site [posttranslational modification] 381764002303 intermolecular recognition site; other site 381764002304 dimerization interface [polypeptide binding]; other site 381764002305 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 381764002306 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 381764002307 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 381764002308 thymidylate kinase; Validated; Region: tmk; PRK00698 381764002309 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 381764002310 TMP-binding site; other site 381764002311 ATP-binding site [chemical binding]; other site 381764002312 hydroxyglutarate oxidase; Provisional; Region: PRK11728 381764002313 Predicted dehydrogenase [General function prediction only]; Region: COG0579 381764002314 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 381764002315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381764002316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 381764002317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381764002318 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 381764002319 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 381764002320 active site 381764002321 metal binding site [ion binding]; metal-binding site 381764002322 dimerization interface [polypeptide binding]; other site 381764002323 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 381764002324 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 381764002325 HflK protein; Region: hflK; TIGR01933 381764002326 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 381764002327 HflC protein; Region: hflC; TIGR01932 381764002328 ornithine carbamoyltransferase; Validated; Region: PRK02102 381764002329 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 381764002330 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 381764002331 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 381764002332 Protein of unknown function (DUF503); Region: DUF503; pfam04456 381764002333 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 381764002334 active site 381764002335 HslU subunit interaction site [polypeptide binding]; other site 381764002336 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 381764002337 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 381764002338 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 381764002339 PLD-like domain; Region: PLDc_2; pfam13091 381764002340 putative active site [active] 381764002341 catalytic site [active] 381764002342 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 381764002343 PLD-like domain; Region: PLDc_2; pfam13091 381764002344 putative active site [active] 381764002345 catalytic site [active] 381764002346 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381764002347 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 381764002348 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 381764002349 Walker A/P-loop; other site 381764002350 ATP binding site [chemical binding]; other site 381764002351 Q-loop/lid; other site 381764002352 ABC transporter signature motif; other site 381764002353 Walker B; other site 381764002354 D-loop; other site 381764002355 H-loop/switch region; other site 381764002356 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381764002357 ABC-2 type transporter; Region: ABC2_membrane; cl17235 381764002358 S-layer homology domain; Region: SLH; pfam00395 381764002359 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 381764002360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764002361 FeS/SAM binding site; other site 381764002362 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 381764002363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 381764002364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 381764002365 DNA binding residues [nucleotide binding] 381764002366 Protein of unknown function DUF72; Region: DUF72; pfam01904 381764002367 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 381764002368 Part of AAA domain; Region: AAA_19; pfam13245 381764002369 Family description; Region: UvrD_C_2; pfam13538 381764002370 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 381764002371 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 381764002372 active site 381764002373 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 381764002374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764002375 Zn2+ binding site [ion binding]; other site 381764002376 Mg2+ binding site [ion binding]; other site 381764002377 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 381764002378 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 381764002379 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 381764002380 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 381764002381 active site 381764002382 dimer interface [polypeptide binding]; other site 381764002383 motif 1; other site 381764002384 motif 2; other site 381764002385 motif 3; other site 381764002386 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 381764002387 anticodon binding site; other site 381764002388 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764002389 Zn2+ binding site [ion binding]; other site 381764002390 Mg2+ binding site [ion binding]; other site 381764002391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 381764002392 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764002393 Integrase core domain; Region: rve; pfam00665 381764002394 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 381764002395 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 381764002396 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 381764002397 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 381764002398 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 381764002399 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 381764002400 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 381764002401 Competence protein; Region: Competence; pfam03772 381764002402 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 381764002403 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 381764002404 metal binding site 2 [ion binding]; metal-binding site 381764002405 putative DNA binding helix; other site 381764002406 metal binding site 1 [ion binding]; metal-binding site 381764002407 dimer interface [polypeptide binding]; other site 381764002408 structural Zn2+ binding site [ion binding]; other site 381764002409 transcription termination factor NusA; Region: NusA; TIGR01953 381764002410 NusA N-terminal domain; Region: NusA_N; pfam08529 381764002411 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 381764002412 RNA binding site [nucleotide binding]; other site 381764002413 homodimer interface [polypeptide binding]; other site 381764002414 NusA-like KH domain; Region: KH_5; pfam13184 381764002415 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 381764002416 G-X-X-G motif; other site 381764002417 Sm and related proteins; Region: Sm_like; cl00259 381764002418 ribosome maturation protein RimP; Reviewed; Region: PRK00092 381764002419 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 381764002420 putative oligomer interface [polypeptide binding]; other site 381764002421 putative RNA binding site [nucleotide binding]; other site 381764002422 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 381764002423 dimer interface [polypeptide binding]; other site 381764002424 substrate binding site [chemical binding]; other site 381764002425 catalytic triad [active] 381764002426 Phosphoglycerate kinase; Region: PGK; pfam00162 381764002427 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 381764002428 substrate binding site [chemical binding]; other site 381764002429 hinge regions; other site 381764002430 ADP binding site [chemical binding]; other site 381764002431 catalytic site [active] 381764002432 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 381764002433 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 381764002434 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 381764002435 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 381764002436 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 381764002437 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 381764002438 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 381764002439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764002440 S-adenosylmethionine binding site [chemical binding]; other site 381764002441 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; Region: MATE_MJ0709_like; cd13147 381764002442 putative efflux protein, MATE family; Region: matE; TIGR00797 381764002443 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 381764002444 Glucose inhibited division protein A; Region: GIDA; pfam01134 381764002445 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 381764002446 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764002447 Integrase core domain; Region: rve; pfam00665 381764002448 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 381764002449 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 381764002450 methionine sulfoxide reductase A; Provisional; Region: PRK14054 381764002451 NAD-dependent deacetylase; Provisional; Region: PRK00481 381764002452 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 381764002453 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 381764002454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764002455 Walker A/P-loop; other site 381764002456 ATP binding site [chemical binding]; other site 381764002457 Q-loop/lid; other site 381764002458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764002459 ABC transporter signature motif; other site 381764002460 Walker B; other site 381764002461 D-loop; other site 381764002462 H-loop/switch region; other site 381764002463 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 381764002464 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 381764002465 active site 381764002466 metal binding site [ion binding]; metal-binding site 381764002467 DNA binding site [nucleotide binding] 381764002468 Staphylococcal nuclease homologues; Region: SNc; smart00318 381764002469 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 381764002470 Catalytic site; other site 381764002471 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 381764002472 Alkaline phosphatase homologues; Region: alkPPc; smart00098 381764002473 active site 381764002474 dimer interface [polypeptide binding]; other site 381764002475 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 381764002476 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 381764002477 dimerization interface [polypeptide binding]; other site 381764002478 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 381764002479 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 381764002480 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 381764002481 Walker A motif/ATP binding site; other site 381764002482 Walker B motif; other site 381764002483 Flagellar assembly protein FliH; Region: FliH; pfam02108 381764002484 propionate/acetate kinase; Provisional; Region: PRK12379 381764002485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 381764002486 nucleotide binding site [chemical binding]; other site 381764002487 butyrate kinase; Provisional; Region: PRK03011 381764002488 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 381764002489 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 381764002490 intersubunit interface [polypeptide binding]; other site 381764002491 active site 381764002492 zinc binding site [ion binding]; other site 381764002493 Na+ binding site [ion binding]; other site 381764002494 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 381764002495 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 381764002496 Cl- selectivity filter; other site 381764002497 Cl- binding residues [ion binding]; other site 381764002498 pore gating glutamate residue; other site 381764002499 dimer interface [polypeptide binding]; other site 381764002500 H+/Cl- coupling transport residue; other site 381764002501 TrkA-C domain; Region: TrkA_C; pfam02080 381764002502 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 381764002503 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 381764002504 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 381764002505 Ligand Binding Site [chemical binding]; other site 381764002506 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 381764002507 substrate binding site [chemical binding]; other site 381764002508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381764002509 oxidoreductase; Validated; Region: PRK05717 381764002510 NAD(P) binding site [chemical binding]; other site 381764002511 active site 381764002512 MMPL family; Region: MMPL; pfam03176 381764002513 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 381764002514 NAD synthetase; Provisional; Region: PRK13981 381764002515 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 381764002516 multimer interface [polypeptide binding]; other site 381764002517 active site 381764002518 catalytic triad [active] 381764002519 protein interface 1 [polypeptide binding]; other site 381764002520 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 381764002521 homodimer interface [polypeptide binding]; other site 381764002522 NAD binding pocket [chemical binding]; other site 381764002523 ATP binding pocket [chemical binding]; other site 381764002524 Mg binding site [ion binding]; other site 381764002525 active-site loop [active] 381764002526 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 381764002527 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 381764002528 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 381764002529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381764002530 putative DNA binding site [nucleotide binding]; other site 381764002531 dimerization interface [polypeptide binding]; other site 381764002532 putative Zn2+ binding site [ion binding]; other site 381764002533 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 381764002534 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 381764002535 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 381764002536 substrate binding pocket [chemical binding]; other site 381764002537 dimer interface [polypeptide binding]; other site 381764002538 inhibitor binding site; inhibition site 381764002539 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 381764002540 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 381764002541 B12 binding site [chemical binding]; other site 381764002542 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 381764002543 HSP70 interaction site [polypeptide binding]; other site 381764002544 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 381764002545 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 381764002546 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 381764002547 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 381764002548 HIGH motif; other site 381764002549 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 381764002550 active site 381764002551 KMSKS motif; other site 381764002552 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 381764002553 Uncharacterized conserved protein [Function unknown]; Region: COG3379 381764002554 Aphid transmission protein; Region: Cauli_AT; pfam03233 381764002555 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764002556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764002557 dimer interface [polypeptide binding]; other site 381764002558 conserved gate region; other site 381764002559 putative PBP binding loops; other site 381764002560 ABC-ATPase subunit interface; other site 381764002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381764002562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764002563 dimer interface [polypeptide binding]; other site 381764002564 conserved gate region; other site 381764002565 putative PBP binding loops; other site 381764002566 ABC-ATPase subunit interface; other site 381764002567 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 381764002568 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381764002569 Predicted GTPase [General function prediction only]; Region: COG2403 381764002570 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381764002571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381764002572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 381764002573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381764002574 dimer interface [polypeptide binding]; other site 381764002575 phosphorylation site [posttranslational modification] 381764002576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764002577 ATP binding site [chemical binding]; other site 381764002578 Mg2+ binding site [ion binding]; other site 381764002579 G-X-G motif; other site 381764002580 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381764002581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764002582 active site 381764002583 phosphorylation site [posttranslational modification] 381764002584 intermolecular recognition site; other site 381764002585 dimerization interface [polypeptide binding]; other site 381764002586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381764002587 DNA binding site [nucleotide binding] 381764002588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764002589 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 381764002590 FeS/SAM binding site; other site 381764002591 Yqey-like protein; Region: YqeY; pfam09424 381764002592 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 381764002593 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 381764002594 active site 381764002595 Zn binding site [ion binding]; other site 381764002596 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 381764002597 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 381764002598 anti sigma factor interaction site; other site 381764002599 regulatory phosphorylation site [posttranslational modification]; other site 381764002600 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 381764002601 anti sigma factor interaction site; other site 381764002602 regulatory phosphorylation site [posttranslational modification]; other site 381764002603 LexA repressor; Validated; Region: PRK00215 381764002604 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 381764002605 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 381764002606 Catalytic site [active] 381764002607 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 381764002608 DNA gyrase subunit A; Validated; Region: PRK05560 381764002609 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 381764002610 CAP-like domain; other site 381764002611 active site 381764002612 primary dimer interface [polypeptide binding]; other site 381764002613 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381764002614 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381764002615 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381764002616 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381764002617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 381764002618 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 381764002619 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 381764002620 active site 381764002621 HIGH motif; other site 381764002622 KMSKS motif; other site 381764002623 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 381764002624 tRNA binding surface [nucleotide binding]; other site 381764002625 anticodon binding site; other site 381764002626 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 381764002627 dimer interface [polypeptide binding]; other site 381764002628 putative tRNA-binding site [nucleotide binding]; other site 381764002629 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 381764002630 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 381764002631 active site 381764002632 metal binding site [ion binding]; metal-binding site 381764002633 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 381764002634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381764002635 thymidine kinase; Provisional; Region: PRK04296 381764002636 AAA domain; Region: AAA_14; pfam13173 381764002637 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764002638 Integrase core domain; Region: rve; pfam00665 381764002639 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 381764002640 active site 381764002641 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 381764002642 RuvA N terminal domain; Region: RuvA_N; pfam01330 381764002643 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 381764002644 DRTGG domain; Region: DRTGG; pfam07085 381764002645 PHP domain; Region: PHP; pfam02811 381764002646 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 381764002647 PHP-associated; Region: PHP_C; pfam13263 381764002648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381764002649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764002650 ATP binding site [chemical binding]; other site 381764002651 Mg2+ binding site [ion binding]; other site 381764002652 G-X-G motif; other site 381764002653 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 381764002654 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381764002655 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 381764002656 Surface antigen; Region: Bac_surface_Ag; pfam01103 381764002657 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 381764002658 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 381764002659 minor groove reading motif; other site 381764002660 helix-hairpin-helix signature motif; other site 381764002661 substrate binding pocket [chemical binding]; other site 381764002662 active site 381764002663 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 381764002664 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 381764002665 Formiminotransferase domain; Region: FTCD; pfam02971 381764002666 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 381764002667 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381764002668 active site 381764002669 catalytic tetrad [active] 381764002670 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 381764002671 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 381764002672 active site 381764002673 dimer interface [polypeptide binding]; other site 381764002674 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 381764002675 active site 381764002676 catalytic site [active] 381764002677 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 381764002678 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 381764002679 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 381764002680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764002681 Walker A motif; other site 381764002682 ATP binding site [chemical binding]; other site 381764002683 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 381764002684 Walker B motif; other site 381764002685 arginine finger; other site 381764002686 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 381764002687 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 381764002688 nucleophilic elbow; other site 381764002689 catalytic triad; other site 381764002690 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 381764002691 GIY-YIG motif/motif A; other site 381764002692 putative active site [active] 381764002693 putative metal binding site [ion binding]; other site 381764002694 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 381764002695 Protein of unknown function DUF58; Region: DUF58; pfam01882 381764002696 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 381764002697 FOG: WD40 repeat [General function prediction only]; Region: COG2319 381764002698 structural tetrad; other site 381764002699 FOG: WD40 repeat [General function prediction only]; Region: COG2319 381764002700 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 381764002701 structural tetrad; other site 381764002702 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 381764002703 dimer interface [polypeptide binding]; other site 381764002704 ADP-ribose binding site [chemical binding]; other site 381764002705 active site 381764002706 nudix motif; other site 381764002707 metal binding site [ion binding]; metal-binding site 381764002708 Flagellar protein FliS; Region: FliS; cl00654 381764002709 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 381764002710 putative CheA interaction surface; other site 381764002711 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 381764002712 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764002713 RNA binding surface [nucleotide binding]; other site 381764002714 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 381764002715 active site 381764002716 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 381764002717 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 381764002718 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 381764002719 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 381764002720 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 381764002721 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 381764002722 GTP/Mg2+ binding site [chemical binding]; other site 381764002723 G4 box; other site 381764002724 G5 box; other site 381764002725 G1 box; other site 381764002726 Switch I region; other site 381764002727 G2 box; other site 381764002728 G3 box; other site 381764002729 Switch II region; other site 381764002730 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 381764002731 putative nucleotide binding site [chemical binding]; other site 381764002732 uridine monophosphate binding site [chemical binding]; other site 381764002733 homohexameric interface [polypeptide binding]; other site 381764002734 Uncharacterized conserved protein [Function unknown]; Region: COG4717 381764002735 Uncharacterized conserved protein [Function unknown]; Region: COG4717 381764002736 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 381764002737 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 381764002738 putative active site [active] 381764002739 PhoH-like protein; Region: PhoH; pfam02562 381764002740 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 381764002741 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 381764002742 active site 381764002743 catalytic site [active] 381764002744 substrate binding site [chemical binding]; other site 381764002745 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 381764002746 MgtE intracellular N domain; Region: MgtE_N; smart00924 381764002747 FliG C-terminal domain; Region: FliG_C; pfam01706 381764002748 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 381764002749 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 381764002750 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 381764002751 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 381764002752 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 381764002753 putative phosphate acyltransferase; Provisional; Region: PRK05331 381764002754 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 381764002755 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 381764002756 glutaminase active site [active] 381764002757 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 381764002758 dimer interface [polypeptide binding]; other site 381764002759 active site 381764002760 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 381764002761 dimer interface [polypeptide binding]; other site 381764002762 active site 381764002763 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 381764002764 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 381764002765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764002766 Walker A motif; other site 381764002767 ATP binding site [chemical binding]; other site 381764002768 Walker B motif; other site 381764002769 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 381764002770 UGMP family protein; Validated; Region: PRK09604 381764002771 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 381764002772 Rod binding protein; Region: Rod-binding; pfam10135 381764002773 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 381764002774 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 381764002775 Flagellar L-ring protein; Region: FlgH; cl17277 381764002776 SAF-like; Region: SAF_2; pfam13144 381764002777 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 381764002778 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 381764002779 mRNA/rRNA interface [nucleotide binding]; other site 381764002780 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 381764002781 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 381764002782 23S rRNA interface [nucleotide binding]; other site 381764002783 L7/L12 interface [polypeptide binding]; other site 381764002784 putative thiostrepton binding site; other site 381764002785 L25 interface [polypeptide binding]; other site 381764002786 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 381764002787 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 381764002788 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 381764002789 putative homodimer interface [polypeptide binding]; other site 381764002790 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 381764002791 heterodimer interface [polypeptide binding]; other site 381764002792 homodimer interface [polypeptide binding]; other site 381764002793 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 381764002794 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 381764002795 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 381764002796 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 381764002797 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 381764002798 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 381764002799 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 381764002800 catalytic residues [active] 381764002801 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 381764002802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381764002803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381764002804 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 381764002805 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 381764002806 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 381764002807 catalytic residues [active] 381764002808 Esterase/lipase [General function prediction only]; Region: COG1647 381764002809 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 381764002810 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 381764002811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 381764002812 ABC-ATPase subunit interface; other site 381764002813 dimer interface [polypeptide binding]; other site 381764002814 putative PBP binding regions; other site 381764002815 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 381764002816 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 381764002817 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 381764002818 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 381764002819 intersubunit interface [polypeptide binding]; other site 381764002820 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 381764002821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764002822 FeS/SAM binding site; other site 381764002823 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 381764002824 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 381764002825 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 381764002826 TPP-binding site [chemical binding]; other site 381764002827 putative dimer interface [polypeptide binding]; other site 381764002828 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 381764002829 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 381764002830 dimer interface [polypeptide binding]; other site 381764002831 PYR/PP interface [polypeptide binding]; other site 381764002832 TPP binding site [chemical binding]; other site 381764002833 substrate binding site [chemical binding]; other site 381764002834 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 381764002835 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381764002836 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 381764002837 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 381764002838 Uncharacterized conserved protein [Function unknown]; Region: COG1543 381764002839 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 381764002840 active site 381764002841 substrate binding site [chemical binding]; other site 381764002842 catalytic site [active] 381764002843 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 381764002844 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 381764002845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 381764002846 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 381764002847 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 381764002848 substrate binding site [chemical binding]; other site 381764002849 ATP binding site [chemical binding]; other site 381764002850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764002851 TPR repeat; Region: TPR_11; pfam13414 381764002852 TPR motif; other site 381764002853 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 381764002854 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 381764002855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764002856 active site 381764002857 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 381764002858 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 381764002859 active site 381764002860 dimer interface [polypeptide binding]; other site 381764002861 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 381764002862 dimer interface [polypeptide binding]; other site 381764002863 active site 381764002864 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 381764002865 CoA-binding site [chemical binding]; other site 381764002866 ATP-binding [chemical binding]; other site 381764002867 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 381764002868 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 381764002869 homodimer interface [polypeptide binding]; other site 381764002870 NAD binding pocket [chemical binding]; other site 381764002871 ATP binding pocket [chemical binding]; other site 381764002872 Mg binding site [ion binding]; other site 381764002873 active-site loop [active] 381764002874 GAF domain; Region: GAF; cl17456 381764002875 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 381764002876 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381764002877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764002878 putative active site [active] 381764002879 heme pocket [chemical binding]; other site 381764002880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381764002881 dimer interface [polypeptide binding]; other site 381764002882 phosphorylation site [posttranslational modification] 381764002883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764002884 ATP binding site [chemical binding]; other site 381764002885 Mg2+ binding site [ion binding]; other site 381764002886 G-X-G motif; other site 381764002887 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 381764002888 tetramerization interface [polypeptide binding]; other site 381764002889 active site 381764002890 Protein of unknown function (DUF342); Region: DUF342; pfam03961 381764002891 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 381764002892 acyl carrier protein; Provisional; Region: acpP; PRK00982 381764002893 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 381764002894 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 381764002895 active site 381764002896 Zn binding site [ion binding]; other site 381764002897 GTP-binding protein LepA; Provisional; Region: PRK05433 381764002898 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 381764002899 G1 box; other site 381764002900 putative GEF interaction site [polypeptide binding]; other site 381764002901 GTP/Mg2+ binding site [chemical binding]; other site 381764002902 Switch I region; other site 381764002903 G2 box; other site 381764002904 G3 box; other site 381764002905 Switch II region; other site 381764002906 G4 box; other site 381764002907 G5 box; other site 381764002908 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 381764002909 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 381764002910 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 381764002911 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 381764002912 Mechanosensitive ion channel; Region: MS_channel; pfam00924 381764002913 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 381764002914 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 381764002915 active site 381764002916 HIGH motif; other site 381764002917 dimer interface [polypeptide binding]; other site 381764002918 KMSKS motif; other site 381764002919 Uncharacterized conserved protein [Function unknown]; Region: COG1633 381764002920 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 381764002921 diiron binding motif [ion binding]; other site 381764002922 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 381764002923 catalytic residues [active] 381764002924 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 381764002925 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 381764002926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 381764002927 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 381764002928 DHH family; Region: DHH; pfam01368 381764002929 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 381764002930 FOG: CBS domain [General function prediction only]; Region: COG0517 381764002931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 381764002932 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 381764002933 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 381764002934 active site 381764002935 NTP binding site [chemical binding]; other site 381764002936 metal binding triad [ion binding]; metal-binding site 381764002937 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 381764002938 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 381764002939 putative active site [active] 381764002940 putative metal binding site [ion binding]; other site 381764002941 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 381764002942 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 381764002943 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 381764002944 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 381764002945 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 381764002946 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 381764002947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764002948 S-adenosylmethionine binding site [chemical binding]; other site 381764002949 Domain of unknown function DUF59; Region: DUF59; cl00941 381764002950 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14319 381764002951 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 381764002952 active site 381764002953 substrate binding site [chemical binding]; other site 381764002954 metal binding site [ion binding]; metal-binding site 381764002955 Uncharacterized conserved protein [Function unknown]; Region: COG2013 381764002956 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 381764002957 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764002958 active site 381764002959 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 381764002960 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 381764002961 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 381764002962 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764002963 Integrase core domain; Region: rve; pfam00665 381764002964 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 381764002965 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 381764002966 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 381764002967 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 381764002968 putative active site [active] 381764002969 substrate binding site [chemical binding]; other site 381764002970 putative cosubstrate binding site; other site 381764002971 catalytic site [active] 381764002972 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 381764002973 substrate binding site [chemical binding]; other site 381764002974 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 381764002975 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 381764002976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764002977 dimer interface [polypeptide binding]; other site 381764002978 putative CheW interface [polypeptide binding]; other site 381764002979 Response regulator receiver domain; Region: Response_reg; pfam00072 381764002980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764002981 active site 381764002982 phosphorylation site [posttranslational modification] 381764002983 intermolecular recognition site; other site 381764002984 dimerization interface [polypeptide binding]; other site 381764002985 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764002986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764002987 metal binding site [ion binding]; metal-binding site 381764002988 active site 381764002989 I-site; other site 381764002990 CheB methylesterase; Region: CheB_methylest; pfam01339 381764002991 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381764002992 putative binding surface; other site 381764002993 active site 381764002994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764002995 ATP binding site [chemical binding]; other site 381764002996 Mg2+ binding site [ion binding]; other site 381764002997 G-X-G motif; other site 381764002998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764002999 Response regulator receiver domain; Region: Response_reg; pfam00072 381764003000 active site 381764003001 phosphorylation site [posttranslational modification] 381764003002 intermolecular recognition site; other site 381764003003 dimerization interface [polypeptide binding]; other site 381764003004 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 381764003005 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 381764003006 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381764003007 EamA-like transporter family; Region: EamA; pfam00892 381764003008 EamA-like transporter family; Region: EamA; pfam00892 381764003009 rod shape-determining protein MreB; Provisional; Region: PRK13930 381764003010 MreB and similar proteins; Region: MreB_like; cd10225 381764003011 nucleotide binding site [chemical binding]; other site 381764003012 Mg binding site [ion binding]; other site 381764003013 putative protofilament interaction site [polypeptide binding]; other site 381764003014 RodZ interaction site [polypeptide binding]; other site 381764003015 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 381764003016 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 381764003017 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 381764003018 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381764003019 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381764003020 membrane protein; Provisional; Region: PRK14406 381764003021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764003022 binding surface 381764003023 TPR motif; other site 381764003024 TPR repeat; Region: TPR_11; pfam13414 381764003025 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 381764003026 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 381764003027 putative acyl-acceptor binding pocket; other site 381764003028 Bifunctional nuclease; Region: DNase-RNase; pfam02577 381764003029 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 381764003030 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 381764003031 putative tRNA-binding site [nucleotide binding]; other site 381764003032 B3/4 domain; Region: B3_4; pfam03483 381764003033 tRNA synthetase B5 domain; Region: B5; smart00874 381764003034 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 381764003035 dimer interface [polypeptide binding]; other site 381764003036 motif 1; other site 381764003037 motif 3; other site 381764003038 motif 2; other site 381764003039 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 381764003040 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 381764003041 putative FMN binding site [chemical binding]; other site 381764003042 NADPH bind site [chemical binding]; other site 381764003043 MoxR-like ATPases [General function prediction only]; Region: COG0714 381764003044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764003045 Walker A motif; other site 381764003046 ATP binding site [chemical binding]; other site 381764003047 Walker B motif; other site 381764003048 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 381764003049 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 381764003050 Family of unknown function (DUF694); Region: DUF694; pfam05107 381764003051 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 381764003052 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 381764003053 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 381764003054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 381764003055 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 381764003056 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 381764003057 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 381764003058 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 381764003059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 381764003060 EamA-like transporter family; Region: EamA; pfam00892 381764003061 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 381764003062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381764003063 ABC transporter; Region: ABC_tran_2; pfam12848 381764003064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 381764003065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 381764003066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764003067 Coenzyme A binding pocket [chemical binding]; other site 381764003068 endonuclease IV; Provisional; Region: PRK01060 381764003069 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 381764003070 AP (apurinic/apyrimidinic) site pocket; other site 381764003071 DNA interaction; other site 381764003072 Metal-binding active site; metal-binding site 381764003073 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 381764003074 putative hydrophobic ligand binding site [chemical binding]; other site 381764003075 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 381764003076 Thiamine pyrophosphokinase; Region: TPK; cd07995 381764003077 active site 381764003078 dimerization interface [polypeptide binding]; other site 381764003079 thiamine binding site [chemical binding]; other site 381764003080 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 381764003081 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 381764003082 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 381764003083 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 381764003084 RIP metalloprotease RseP; Region: TIGR00054 381764003085 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 381764003086 active site 381764003087 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 381764003088 protein binding site [polypeptide binding]; other site 381764003089 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 381764003090 putative substrate binding region [chemical binding]; other site 381764003091 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 381764003092 GcpE protein; Region: GcpE; pfam04551 381764003093 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 381764003094 stationary phase survival protein SurE; Provisional; Region: PRK13935 381764003095 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 381764003096 active site 381764003097 catalytic residues [active] 381764003098 metal binding site [ion binding]; metal-binding site 381764003099 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 381764003100 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 381764003101 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 381764003102 active site 381764003103 substrate binding site [chemical binding]; other site 381764003104 metal binding site [ion binding]; metal-binding site 381764003105 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 381764003106 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 381764003107 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 381764003108 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 381764003109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381764003110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381764003111 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 381764003112 Walker A/P-loop; other site 381764003113 ATP binding site [chemical binding]; other site 381764003114 Q-loop/lid; other site 381764003115 ABC transporter signature motif; other site 381764003116 Walker B; other site 381764003117 D-loop; other site 381764003118 H-loop/switch region; other site 381764003119 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 381764003120 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 381764003121 GAF domain; Region: GAF; cl17456 381764003122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764003123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764003124 metal binding site [ion binding]; metal-binding site 381764003125 active site 381764003126 I-site; other site 381764003127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764003128 RNA binding surface [nucleotide binding]; other site 381764003129 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 381764003130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764003131 ATP binding site [chemical binding]; other site 381764003132 Mg2+ binding site [ion binding]; other site 381764003133 G-X-G motif; other site 381764003134 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 381764003135 anchoring element; other site 381764003136 dimer interface [polypeptide binding]; other site 381764003137 ATP binding site [chemical binding]; other site 381764003138 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 381764003139 active site 381764003140 putative metal-binding site [ion binding]; other site 381764003141 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 381764003142 Protein of unknown function (DUF721); Region: DUF721; pfam05258 381764003143 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 381764003144 homodimer interface [polypeptide binding]; other site 381764003145 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 381764003146 substrate-cofactor binding pocket; other site 381764003147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764003148 catalytic residue [active] 381764003149 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 381764003150 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 381764003151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764003152 FeS/SAM binding site; other site 381764003153 FOG: CBS domain [General function prediction only]; Region: COG0517 381764003154 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 381764003155 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 381764003156 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 381764003157 putative substrate binding site [chemical binding]; other site 381764003158 putative ATP binding site [chemical binding]; other site 381764003159 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 381764003160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764003161 Walker A/P-loop; other site 381764003162 ATP binding site [chemical binding]; other site 381764003163 Q-loop/lid; other site 381764003164 ABC transporter signature motif; other site 381764003165 Walker B; other site 381764003166 D-loop; other site 381764003167 H-loop/switch region; other site 381764003168 aspartate aminotransferase; Provisional; Region: PRK05764 381764003169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381764003170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764003171 homodimer interface [polypeptide binding]; other site 381764003172 catalytic residue [active] 381764003173 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 381764003174 tetramer interface [polypeptide binding]; other site 381764003175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764003176 catalytic residue [active] 381764003177 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 381764003178 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 381764003179 tetramer interface [polypeptide binding]; other site 381764003180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764003181 catalytic residue [active] 381764003182 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 381764003183 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 381764003184 POPLD (NUC188) domain; Region: POPLD; pfam08170 381764003185 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 381764003186 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 381764003187 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 381764003188 active site 381764003189 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 381764003190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764003191 FeS/SAM binding site; other site 381764003192 Rhomboid family; Region: Rhomboid; pfam01694 381764003193 hypothetical protein; Provisional; Region: PRK14628 381764003194 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 381764003195 ApbE family; Region: ApbE; pfam02424 381764003196 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 381764003197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764003198 FeS/SAM binding site; other site 381764003199 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 381764003200 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 381764003201 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 381764003202 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 381764003203 hexamer interface [polypeptide binding]; other site 381764003204 metal binding site [ion binding]; metal-binding site 381764003205 substrate binding site [chemical binding]; other site 381764003206 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 381764003207 PhoH-like protein; Region: PhoH; pfam02562 381764003208 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 381764003209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003210 Zn2+ binding site [ion binding]; other site 381764003211 Mg2+ binding site [ion binding]; other site 381764003212 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 381764003213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 381764003214 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 381764003215 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 381764003216 dimer interface [polypeptide binding]; other site 381764003217 [2Fe-2S] cluster binding site [ion binding]; other site 381764003218 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 381764003219 SLBB domain; Region: SLBB; pfam10531 381764003220 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 381764003221 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 381764003222 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 381764003223 putative dimer interface [polypeptide binding]; other site 381764003224 [2Fe-2S] cluster binding site [ion binding]; other site 381764003225 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 381764003226 dimer interface [polypeptide binding]; other site 381764003227 [2Fe-2S] cluster binding site [ion binding]; other site 381764003228 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 381764003229 SLBB domain; Region: SLBB; pfam10531 381764003230 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 381764003231 4Fe-4S binding domain; Region: Fer4; pfam00037 381764003232 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 381764003233 4Fe-4S binding domain; Region: Fer4; pfam00037 381764003234 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 381764003235 dimer interface [polypeptide binding]; other site 381764003236 [2Fe-2S] cluster binding site [ion binding]; other site 381764003237 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 381764003238 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 381764003239 putative dimer interface [polypeptide binding]; other site 381764003240 [2Fe-2S] cluster binding site [ion binding]; other site 381764003241 EamA-like transporter family; Region: EamA; pfam00892 381764003242 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 381764003243 EamA-like transporter family; Region: EamA; pfam00892 381764003244 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 381764003245 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 381764003246 putative substrate binding pocket [chemical binding]; other site 381764003247 AC domain interface; other site 381764003248 catalytic triad [active] 381764003249 AB domain interface; other site 381764003250 interchain disulfide; other site 381764003251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 381764003252 intermolecular recognition site; other site 381764003253 active site 381764003254 dimerization interface [polypeptide binding]; other site 381764003255 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 381764003256 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 381764003257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764003258 Walker A/P-loop; other site 381764003259 ATP binding site [chemical binding]; other site 381764003260 Q-loop/lid; other site 381764003261 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 381764003262 ABC transporter signature motif; other site 381764003263 Walker B; other site 381764003264 D-loop; other site 381764003265 H-loop/switch region; other site 381764003266 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 381764003267 active site 381764003268 catalytic motif [active] 381764003269 Zn binding site [ion binding]; other site 381764003270 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 381764003271 Domain of unknown function DUF21; Region: DUF21; pfam01595 381764003272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 381764003273 Transporter associated domain; Region: CorC_HlyC; smart01091 381764003274 PAS domain S-box; Region: sensory_box; TIGR00229 381764003275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764003276 putative active site [active] 381764003277 heme pocket [chemical binding]; other site 381764003278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764003279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764003280 metal binding site [ion binding]; metal-binding site 381764003281 active site 381764003282 I-site; other site 381764003283 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 381764003284 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 381764003285 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 381764003286 Ligand Binding Site [chemical binding]; other site 381764003287 TIGR00269 family protein; Region: TIGR00269 381764003288 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 381764003289 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 381764003290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 381764003291 protein binding site [polypeptide binding]; other site 381764003292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764003293 binding surface 381764003294 TPR motif; other site 381764003295 TPR repeat; Region: TPR_11; pfam13414 381764003296 Tetratricopeptide repeat; Region: TPR_12; pfam13424 381764003297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764003298 binding surface 381764003299 TPR motif; other site 381764003300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 381764003301 binding surface 381764003302 TPR motif; other site 381764003303 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 381764003304 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 381764003305 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 381764003306 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381764003307 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381764003308 catalytic residue [active] 381764003309 Uncharacterized conserved protein [Function unknown]; Region: COG0062 381764003310 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 381764003311 putative substrate binding site [chemical binding]; other site 381764003312 putative ATP binding site [chemical binding]; other site 381764003313 Haemagglutinin-neuraminidase; Region: HN; pfam00423 381764003314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764003315 S-adenosylmethionine binding site [chemical binding]; other site 381764003316 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 381764003317 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 381764003318 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 381764003319 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 381764003320 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 381764003321 homodimer interface [polypeptide binding]; other site 381764003322 metal binding site [ion binding]; metal-binding site 381764003323 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 381764003324 homodimer interface [polypeptide binding]; other site 381764003325 active site 381764003326 putative chemical substrate binding site [chemical binding]; other site 381764003327 metal binding site [ion binding]; metal-binding site 381764003328 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 381764003329 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 381764003330 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 381764003331 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 381764003332 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 381764003333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 381764003334 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 381764003335 Y-family of DNA polymerases; Region: PolY; cl12025 381764003336 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 381764003337 generic binding surface II; other site 381764003338 ssDNA binding site; other site 381764003339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764003340 ATP binding site [chemical binding]; other site 381764003341 putative Mg++ binding site [ion binding]; other site 381764003342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764003343 nucleotide binding region [chemical binding]; other site 381764003344 ATP-binding site [chemical binding]; other site 381764003345 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 381764003346 lipoyl attachment site [posttranslational modification]; other site 381764003347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764003348 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764003349 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 381764003350 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 381764003351 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 381764003352 active site 381764003353 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 381764003354 dimer interface [polypeptide binding]; other site 381764003355 substrate binding site [chemical binding]; other site 381764003356 catalytic residues [active] 381764003357 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 381764003358 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 381764003359 generic binding surface II; other site 381764003360 generic binding surface I; other site 381764003361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003362 Zn2+ binding site [ion binding]; other site 381764003363 Mg2+ binding site [ion binding]; other site 381764003364 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 381764003365 DNA topoisomerase I; Validated; Region: PRK06599 381764003366 active site 381764003367 interdomain interaction site; other site 381764003368 putative metal-binding site [ion binding]; other site 381764003369 nucleotide binding site [chemical binding]; other site 381764003370 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 381764003371 domain I; other site 381764003372 DNA binding groove [nucleotide binding] 381764003373 phosphate binding site [ion binding]; other site 381764003374 domain II; other site 381764003375 domain III; other site 381764003376 nucleotide binding site [chemical binding]; other site 381764003377 catalytic site [active] 381764003378 domain IV; other site 381764003379 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381764003380 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 381764003381 active site 381764003382 metal binding site [ion binding]; metal-binding site 381764003383 Domain of unknown function (DUF368); Region: DUF368; pfam04018 381764003384 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 381764003385 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 381764003386 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 381764003387 dimer interface [polypeptide binding]; other site 381764003388 motif 1; other site 381764003389 active site 381764003390 motif 2; other site 381764003391 motif 3; other site 381764003392 tRNA pseudouridine synthase B; Provisional; Region: PRK14124 381764003393 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 381764003394 RNA binding site [nucleotide binding]; other site 381764003395 active site 381764003396 GTP-binding protein YchF; Reviewed; Region: PRK09601 381764003397 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381764003398 G1 box; other site 381764003399 GTP/Mg2+ binding site [chemical binding]; other site 381764003400 G2 box; other site 381764003401 Switch I region; other site 381764003402 G3 box; other site 381764003403 Switch II region; other site 381764003404 G4 box; other site 381764003405 G5 box; other site 381764003406 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 381764003407 Domain of unknown function (DUF370); Region: DUF370; cl00898 381764003408 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 381764003409 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 381764003410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764003411 FeS/SAM binding site; other site 381764003412 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 381764003413 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 381764003414 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 381764003415 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 381764003416 G-X-X-G motif; other site 381764003417 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 381764003418 RxxxH motif; other site 381764003419 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 381764003420 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 381764003421 Haemolytic domain; Region: Haemolytic; pfam01809 381764003422 Ribonuclease P; Region: Ribonuclease_P; pfam00825 381764003423 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 381764003424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764003425 Coenzyme A binding pocket [chemical binding]; other site 381764003426 hypothetical protein; Provisional; Region: PRK10621 381764003427 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 381764003428 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434 381764003429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381764003430 dipeptidase PepV; Reviewed; Region: PRK07318 381764003431 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 381764003432 active site 381764003433 metal binding site [ion binding]; metal-binding site 381764003434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381764003435 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 381764003436 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381764003437 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381764003438 NlpC/P60 family; Region: NLPC_P60; pfam00877 381764003439 Predicted permeases [General function prediction only]; Region: COG0679 381764003440 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 381764003441 dimer interface [polypeptide binding]; other site 381764003442 motif 1; other site 381764003443 active site 381764003444 motif 2; other site 381764003445 motif 3; other site 381764003446 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 381764003447 DALR anticodon binding domain; Region: DALR_1; pfam05746 381764003448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381764003449 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381764003450 substrate binding pocket [chemical binding]; other site 381764003451 membrane-bound complex binding site; other site 381764003452 hinge residues; other site 381764003453 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 381764003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764003455 dimer interface [polypeptide binding]; other site 381764003456 conserved gate region; other site 381764003457 putative PBP binding loops; other site 381764003458 ABC-ATPase subunit interface; other site 381764003459 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 381764003460 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 381764003461 Walker A/P-loop; other site 381764003462 ATP binding site [chemical binding]; other site 381764003463 Q-loop/lid; other site 381764003464 ABC transporter signature motif; other site 381764003465 Walker B; other site 381764003466 D-loop; other site 381764003467 H-loop/switch region; other site 381764003468 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 381764003469 generic binding surface I; other site 381764003470 generic binding surface II; other site 381764003471 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 381764003472 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 381764003473 active site 381764003474 catalytic residues [active] 381764003475 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 381764003476 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 381764003477 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 381764003478 NAD(P) binding site [chemical binding]; other site 381764003479 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 381764003480 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 381764003481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381764003482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381764003483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764003484 Walker A/P-loop; other site 381764003485 ATP binding site [chemical binding]; other site 381764003486 Q-loop/lid; other site 381764003487 ABC transporter signature motif; other site 381764003488 Walker B; other site 381764003489 D-loop; other site 381764003490 H-loop/switch region; other site 381764003491 GAF domain; Region: GAF_3; pfam13492 381764003492 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764003493 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764003494 metal binding site [ion binding]; metal-binding site 381764003495 active site 381764003496 I-site; other site 381764003497 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 381764003498 active site 381764003499 catalytic residues [active] 381764003500 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 381764003501 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 381764003502 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 381764003503 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764003504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764003505 metal binding site [ion binding]; metal-binding site 381764003506 active site 381764003507 I-site; other site 381764003508 HD domain; Region: HD_3; cl17350 381764003509 septum formation inhibitor; Provisional; Region: minC; PRK13992 381764003510 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 381764003511 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 381764003512 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 381764003513 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 381764003514 oligomer interface [polypeptide binding]; other site 381764003515 active site 381764003516 metal binding site [ion binding]; metal-binding site 381764003517 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 381764003518 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 381764003519 oligomer interface [polypeptide binding]; other site 381764003520 active site 381764003521 metal binding site [ion binding]; metal-binding site 381764003522 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 381764003523 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764003524 Integrase core domain; Region: rve; pfam00665 381764003525 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 381764003526 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 381764003527 Potassium binding sites [ion binding]; other site 381764003528 Cesium cation binding sites [ion binding]; other site 381764003529 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 381764003530 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 381764003531 Ligand Binding Site [chemical binding]; other site 381764003532 ribonuclease III; Reviewed; Region: rnc; PRK00102 381764003533 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 381764003534 dimerization interface [polypeptide binding]; other site 381764003535 active site 381764003536 metal binding site [ion binding]; metal-binding site 381764003537 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 381764003538 dsRNA binding site [nucleotide binding]; other site 381764003539 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 381764003540 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 381764003541 active site 381764003542 DNA binding site [nucleotide binding] 381764003543 Int/Topo IB signature motif; other site 381764003544 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 381764003545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003546 Zn2+ binding site [ion binding]; other site 381764003547 Mg2+ binding site [ion binding]; other site 381764003548 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 381764003549 synthetase active site [active] 381764003550 NTP binding site [chemical binding]; other site 381764003551 metal binding site [ion binding]; metal-binding site 381764003552 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 381764003553 ACT domain; Region: ACT_4; pfam13291 381764003554 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 381764003555 putative active site [active] 381764003556 dimerization interface [polypeptide binding]; other site 381764003557 putative tRNAtyr binding site [nucleotide binding]; other site 381764003558 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 381764003559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 381764003560 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 381764003561 Divergent PAP2 family; Region: DUF212; cl00855 381764003562 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 381764003563 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 381764003564 N-acetyl-D-glucosamine binding site [chemical binding]; other site 381764003565 catalytic residue [active] 381764003566 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 381764003567 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 381764003568 Walker A/P-loop; other site 381764003569 ATP binding site [chemical binding]; other site 381764003570 Q-loop/lid; other site 381764003571 ABC transporter signature motif; other site 381764003572 Walker B; other site 381764003573 D-loop; other site 381764003574 H-loop/switch region; other site 381764003575 uracil transporter; Provisional; Region: PRK10720 381764003576 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 381764003577 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 381764003578 ATP-grasp domain; Region: ATP-grasp; pfam02222 381764003579 AIR carboxylase; Region: AIRC; pfam00731 381764003580 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 381764003581 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 381764003582 active site 381764003583 ATP binding site [chemical binding]; other site 381764003584 substrate binding site [chemical binding]; other site 381764003585 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 381764003586 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 381764003587 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 381764003588 putative active site [active] 381764003589 catalytic triad [active] 381764003590 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK14090 381764003591 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 381764003592 dimerization interface [polypeptide binding]; other site 381764003593 ATP binding site [chemical binding]; other site 381764003594 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 381764003595 dimerization interface [polypeptide binding]; other site 381764003596 ATP binding site [chemical binding]; other site 381764003597 tumor necrosis factor alpha-inducing protein; Reviewed; Region: PRK12303 381764003598 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 381764003599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003600 Zn2+ binding site [ion binding]; other site 381764003601 Mg2+ binding site [ion binding]; other site 381764003602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 381764003603 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764003604 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381764003605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764003606 dimer interface [polypeptide binding]; other site 381764003607 putative CheW interface [polypeptide binding]; other site 381764003608 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 381764003609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003610 Zn2+ binding site [ion binding]; other site 381764003611 Mg2+ binding site [ion binding]; other site 381764003612 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 381764003613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764003614 RNA binding surface [nucleotide binding]; other site 381764003615 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 381764003616 active site 381764003617 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 381764003618 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 381764003619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764003620 S-adenosylmethionine binding site [chemical binding]; other site 381764003621 hypothetical protein; Validated; Region: PRK00110 381764003622 Clp protease; Region: CLP_protease; pfam00574 381764003623 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 381764003624 oligomer interface [polypeptide binding]; other site 381764003625 active site residues [active] 381764003626 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 381764003627 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 381764003628 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 381764003629 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 381764003630 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 381764003631 alphaNTD homodimer interface [polypeptide binding]; other site 381764003632 alphaNTD - beta interaction site [polypeptide binding]; other site 381764003633 alphaNTD - beta' interaction site [polypeptide binding]; other site 381764003634 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 381764003635 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 381764003636 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 381764003637 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 381764003638 RNA binding surface [nucleotide binding]; other site 381764003639 30S ribosomal protein S11; Validated; Region: PRK05309 381764003640 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 381764003641 30S ribosomal protein S13; Region: bact_S13; TIGR03631 381764003642 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 381764003643 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 381764003644 rRNA binding site [nucleotide binding]; other site 381764003645 predicted 30S ribosome binding site; other site 381764003646 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 381764003647 active site 381764003648 adenylate kinase; Reviewed; Region: adk; PRK00279 381764003649 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 381764003650 AMP-binding site [chemical binding]; other site 381764003651 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 381764003652 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 381764003653 SecY translocase; Region: SecY; pfam00344 381764003654 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 381764003655 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 381764003656 23S rRNA binding site [nucleotide binding]; other site 381764003657 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 381764003658 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 381764003659 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 381764003660 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 381764003661 23S rRNA interface [nucleotide binding]; other site 381764003662 5S rRNA interface [nucleotide binding]; other site 381764003663 L27 interface [polypeptide binding]; other site 381764003664 L5 interface [polypeptide binding]; other site 381764003665 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 381764003666 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 381764003667 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 381764003668 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 381764003669 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 381764003670 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 381764003671 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 381764003672 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 381764003673 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 381764003674 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 381764003675 RNA binding site [nucleotide binding]; other site 381764003676 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 381764003677 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 381764003678 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 381764003679 putative translocon interaction site; other site 381764003680 23S rRNA interface [nucleotide binding]; other site 381764003681 signal recognition particle (SRP54) interaction site; other site 381764003682 L23 interface [polypeptide binding]; other site 381764003683 trigger factor interaction site; other site 381764003684 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 381764003685 23S rRNA interface [nucleotide binding]; other site 381764003686 5S rRNA interface [nucleotide binding]; other site 381764003687 putative antibiotic binding site [chemical binding]; other site 381764003688 L25 interface [polypeptide binding]; other site 381764003689 L27 interface [polypeptide binding]; other site 381764003690 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 381764003691 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 381764003692 G-X-X-G motif; other site 381764003693 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 381764003694 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 381764003695 putative translocon binding site; other site 381764003696 protein-rRNA interface [nucleotide binding]; other site 381764003697 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 381764003698 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 381764003699 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 381764003700 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 381764003701 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 381764003702 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 381764003703 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 381764003704 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 381764003705 elongation factor Tu; Reviewed; Region: PRK00049 381764003706 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 381764003707 G1 box; other site 381764003708 GEF interaction site [polypeptide binding]; other site 381764003709 GTP/Mg2+ binding site [chemical binding]; other site 381764003710 Switch I region; other site 381764003711 G2 box; other site 381764003712 G3 box; other site 381764003713 Switch II region; other site 381764003714 G4 box; other site 381764003715 G5 box; other site 381764003716 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 381764003717 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 381764003718 Antibiotic Binding Site [chemical binding]; other site 381764003719 elongation factor G; Reviewed; Region: PRK00007 381764003720 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 381764003721 G1 box; other site 381764003722 putative GEF interaction site [polypeptide binding]; other site 381764003723 GTP/Mg2+ binding site [chemical binding]; other site 381764003724 Switch I region; other site 381764003725 G2 box; other site 381764003726 G3 box; other site 381764003727 Switch II region; other site 381764003728 G4 box; other site 381764003729 G5 box; other site 381764003730 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 381764003731 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 381764003732 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 381764003733 30S ribosomal protein S7; Validated; Region: PRK05302 381764003734 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 381764003735 S17 interaction site [polypeptide binding]; other site 381764003736 S8 interaction site; other site 381764003737 16S rRNA interaction site [nucleotide binding]; other site 381764003738 streptomycin interaction site [chemical binding]; other site 381764003739 23S rRNA interaction site [nucleotide binding]; other site 381764003740 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 381764003741 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 381764003742 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381764003743 homodimer interface [polypeptide binding]; other site 381764003744 active site 381764003745 catalytic site [active] 381764003746 maltose binding site 2 [chemical binding]; other site 381764003747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764003748 putative substrate translocation pore; other site 381764003749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 381764003750 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 381764003751 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 381764003752 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 381764003753 glyoxylate reductase; Reviewed; Region: PRK13243 381764003754 dimerization interface [polypeptide binding]; other site 381764003755 ligand binding site [chemical binding]; other site 381764003756 NADP binding site [chemical binding]; other site 381764003757 catalytic site [active] 381764003758 Peptidase family M48; Region: Peptidase_M48; pfam01435 381764003759 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 381764003760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764003761 S-adenosylmethionine binding site [chemical binding]; other site 381764003762 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 381764003763 purine monophosphate binding site [chemical binding]; other site 381764003764 dimer interface [polypeptide binding]; other site 381764003765 putative catalytic residues [active] 381764003766 C factor cell-cell signaling protein; Provisional; Region: PRK09009 381764003767 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 381764003768 NADP binding site [chemical binding]; other site 381764003769 homodimer interface [polypeptide binding]; other site 381764003770 active site 381764003771 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 381764003772 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 381764003773 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 381764003774 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 381764003775 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 381764003776 dimer interface [polypeptide binding]; other site 381764003777 putative anticodon binding site; other site 381764003778 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 381764003779 motif 1; other site 381764003780 active site 381764003781 motif 2; other site 381764003782 motif 3; other site 381764003783 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 381764003784 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 381764003785 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 381764003786 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 381764003787 ATP cone domain; Region: ATP-cone; pfam03477 381764003788 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 381764003789 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 381764003790 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 381764003791 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 381764003792 phosphate binding site [ion binding]; other site 381764003793 putative substrate binding pocket [chemical binding]; other site 381764003794 dimer interface [polypeptide binding]; other site 381764003795 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 381764003796 AAA domain; Region: AAA_18; pfam13238 381764003797 glutamate racemase; Provisional; Region: PRK00865 381764003798 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 381764003799 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 381764003800 Peptidase family M50; Region: Peptidase_M50; pfam02163 381764003801 putative substrate binding region [chemical binding]; other site 381764003802 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764003803 Integrase core domain; Region: rve; pfam00665 381764003804 Radical SAM superfamily; Region: Radical_SAM; pfam04055 381764003805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 381764003806 FeS/SAM binding site; other site 381764003807 pantothenate kinase; Reviewed; Region: PRK13318 381764003808 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 381764003809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003810 Zn2+ binding site [ion binding]; other site 381764003811 Mg2+ binding site [ion binding]; other site 381764003812 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 381764003813 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 381764003814 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 381764003815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381764003816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764003817 dimer interface [polypeptide binding]; other site 381764003818 conserved gate region; other site 381764003819 putative PBP binding loops; other site 381764003820 ABC-ATPase subunit interface; other site 381764003821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 381764003822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764003823 dimer interface [polypeptide binding]; other site 381764003824 conserved gate region; other site 381764003825 putative PBP binding loops; other site 381764003826 ABC-ATPase subunit interface; other site 381764003827 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 381764003828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764003829 Walker A/P-loop; other site 381764003830 ATP binding site [chemical binding]; other site 381764003831 Q-loop/lid; other site 381764003832 ABC transporter signature motif; other site 381764003833 Walker B; other site 381764003834 D-loop; other site 381764003835 H-loop/switch region; other site 381764003836 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764003837 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 381764003838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764003839 Walker A/P-loop; other site 381764003840 ATP binding site [chemical binding]; other site 381764003841 Q-loop/lid; other site 381764003842 ABC transporter signature motif; other site 381764003843 Walker B; other site 381764003844 D-loop; other site 381764003845 H-loop/switch region; other site 381764003846 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764003847 flavodoxin; Provisional; Region: PRK06242 381764003848 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 381764003849 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 381764003850 putative active site [active] 381764003851 metal binding site [ion binding]; metal-binding site 381764003852 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 381764003853 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 381764003854 NAD binding site [chemical binding]; other site 381764003855 dimer interface [polypeptide binding]; other site 381764003856 substrate binding site [chemical binding]; other site 381764003857 tetramer (dimer of dimers) interface [polypeptide binding]; other site 381764003858 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381764003859 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 381764003860 Ca binding site [ion binding]; other site 381764003861 active site 381764003862 catalytic site [active] 381764003863 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 381764003864 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 381764003865 glycogen binding site [chemical binding]; other site 381764003866 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 381764003867 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 381764003868 aspartate aminotransferase; Provisional; Region: PRK07568 381764003869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381764003870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764003871 homodimer interface [polypeptide binding]; other site 381764003872 catalytic residue [active] 381764003873 Uncharacterized conserved protein [Function unknown]; Region: COG1739 381764003874 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 381764003875 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 381764003876 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381764003877 active site 381764003878 metal binding site [ion binding]; metal-binding site 381764003879 homotetramer interface [polypeptide binding]; other site 381764003880 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 381764003881 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 381764003882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764003883 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764003884 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 381764003885 PrcB C-terminal; Region: PrcB_C; pfam14343 381764003886 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764003887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764003888 metal binding site [ion binding]; metal-binding site 381764003889 active site 381764003890 I-site; other site 381764003891 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 381764003892 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 381764003893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764003894 FeS/SAM binding site; other site 381764003895 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 381764003896 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 381764003897 Dimer interface [polypeptide binding]; other site 381764003898 anticodon binding site; other site 381764003899 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 381764003900 homodimer interface [polypeptide binding]; other site 381764003901 motif 1; other site 381764003902 motif 2; other site 381764003903 active site 381764003904 motif 3; other site 381764003905 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 381764003906 NlpC/P60 family; Region: NLPC_P60; cl17555 381764003907 Putative amidase domain; Region: Amidase_6; pfam12671 381764003908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 381764003909 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764003910 Integrase core domain; Region: rve; pfam00665 381764003911 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 381764003912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764003913 Coenzyme A binding pocket [chemical binding]; other site 381764003914 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 381764003915 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 381764003916 GTP/Mg2+ binding site [chemical binding]; other site 381764003917 G4 box; other site 381764003918 G5 box; other site 381764003919 G1 box; other site 381764003920 Switch I region; other site 381764003921 G2 box; other site 381764003922 G3 box; other site 381764003923 Switch II region; other site 381764003924 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 381764003925 Propanediol utilisation protein PduL; Region: PduL; pfam06130 381764003926 Propanediol utilisation protein PduL; Region: PduL; pfam06130 381764003927 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 381764003928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764003929 Zn2+ binding site [ion binding]; other site 381764003930 Mg2+ binding site [ion binding]; other site 381764003931 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 381764003932 DNA polymerase III subunit beta; Validated; Region: PRK05643 381764003933 putative DNA binding surface [nucleotide binding]; other site 381764003934 dimer interface [polypeptide binding]; other site 381764003935 beta-clamp/clamp loader binding surface; other site 381764003936 beta-clamp/translesion DNA polymerase binding surface; other site 381764003937 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 381764003938 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 381764003939 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 381764003940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 381764003941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381764003942 Walker A/P-loop; other site 381764003943 ATP binding site [chemical binding]; other site 381764003944 Q-loop/lid; other site 381764003945 ABC transporter signature motif; other site 381764003946 Walker B; other site 381764003947 D-loop; other site 381764003948 H-loop/switch region; other site 381764003949 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 381764003950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 381764003951 Coenzyme A binding pocket [chemical binding]; other site 381764003952 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 381764003953 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 381764003954 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 381764003955 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 381764003956 nucleotide binding site [chemical binding]; other site 381764003957 NEF interaction site [polypeptide binding]; other site 381764003958 SBD interface [polypeptide binding]; other site 381764003959 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 381764003960 active site 381764003961 catalytic residues [active] 381764003962 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 381764003963 dinuclear metal binding motif [ion binding]; other site 381764003964 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 381764003965 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 381764003966 active site 381764003967 Zn binding site [ion binding]; other site 381764003968 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 381764003969 oligomerization interface [polypeptide binding]; other site 381764003970 active site 381764003971 metal binding site [ion binding]; metal-binding site 381764003972 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 381764003973 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 381764003974 active site 381764003975 homotetramer interface [polypeptide binding]; other site 381764003976 homodimer interface [polypeptide binding]; other site 381764003977 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 381764003978 Uncharacterized conserved protein [Function unknown]; Region: COG1434 381764003979 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 381764003980 putative active site [active] 381764003981 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 381764003982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 381764003983 PAS fold; Region: PAS_4; pfam08448 381764003984 GAF domain; Region: GAF; cl17456 381764003985 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 381764003986 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 381764003987 Walker A/P-loop; other site 381764003988 ATP binding site [chemical binding]; other site 381764003989 Q-loop/lid; other site 381764003990 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 381764003991 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 381764003992 ABC transporter signature motif; other site 381764003993 Walker B; other site 381764003994 D-loop; other site 381764003995 H-loop/switch region; other site 381764003996 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 381764003997 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 381764003998 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381764003999 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381764004000 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 381764004001 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 381764004002 active site 381764004003 homodimer interface [polypeptide binding]; other site 381764004004 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 381764004005 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 381764004006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764004007 FeS/SAM binding site; other site 381764004008 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 381764004009 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 381764004010 GatB domain; Region: GatB_Yqey; smart00845 381764004011 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 381764004012 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 381764004013 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 381764004014 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 381764004015 active site 381764004016 intersubunit interactions; other site 381764004017 catalytic residue [active] 381764004018 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 381764004019 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 381764004020 dimer interface [polypeptide binding]; other site 381764004021 anticodon binding site; other site 381764004022 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 381764004023 homodimer interface [polypeptide binding]; other site 381764004024 motif 1; other site 381764004025 active site 381764004026 motif 2; other site 381764004027 GAD domain; Region: GAD; pfam02938 381764004028 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 381764004029 active site 381764004030 motif 3; other site 381764004031 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 381764004032 anti sigma factor interaction site; other site 381764004033 regulatory phosphorylation site [posttranslational modification]; other site 381764004034 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 381764004035 cytidylate kinase; Provisional; Region: cmk; PRK00023 381764004036 CMP-binding site; other site 381764004037 The sites determining sugar specificity; other site 381764004038 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 381764004039 LytB protein; Region: LYTB; cl00507 381764004040 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 381764004041 RNA binding site [nucleotide binding]; other site 381764004042 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 381764004043 RNA binding site [nucleotide binding]; other site 381764004044 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 381764004045 RNA binding site [nucleotide binding]; other site 381764004046 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 381764004047 RNA binding site [nucleotide binding]; other site 381764004048 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 381764004049 RNA binding site [nucleotide binding]; other site 381764004050 GTP-binding protein Der; Reviewed; Region: PRK00093 381764004051 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 381764004052 G1 box; other site 381764004053 GTP/Mg2+ binding site [chemical binding]; other site 381764004054 Switch I region; other site 381764004055 G2 box; other site 381764004056 Switch II region; other site 381764004057 G3 box; other site 381764004058 G4 box; other site 381764004059 G5 box; other site 381764004060 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 381764004061 G1 box; other site 381764004062 GTP/Mg2+ binding site [chemical binding]; other site 381764004063 Switch I region; other site 381764004064 G2 box; other site 381764004065 G3 box; other site 381764004066 Switch II region; other site 381764004067 G4 box; other site 381764004068 G5 box; other site 381764004069 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764004070 Zn2+ binding site [ion binding]; other site 381764004071 Mg2+ binding site [ion binding]; other site 381764004072 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381764004073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381764004074 substrate binding pocket [chemical binding]; other site 381764004075 membrane-bound complex binding site; other site 381764004076 hinge residues; other site 381764004077 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 381764004078 rRNA interaction site [nucleotide binding]; other site 381764004079 S8 interaction site; other site 381764004080 putative laminin-1 binding site; other site 381764004081 EamA-like transporter family; Region: EamA; pfam00892 381764004082 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 381764004083 EamA-like transporter family; Region: EamA; pfam00892 381764004084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 381764004085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 381764004086 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 381764004087 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 381764004088 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 381764004089 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 381764004090 GrpE; Region: GrpE; pfam01025 381764004091 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 381764004092 dimer interface [polypeptide binding]; other site 381764004093 chaperone protein DnaJ; Provisional; Region: PRK14282 381764004094 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 381764004095 HSP70 interaction site [polypeptide binding]; other site 381764004096 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 381764004097 Zn binding sites [ion binding]; other site 381764004098 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 381764004099 dimer interface [polypeptide binding]; other site 381764004100 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 381764004101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764004102 active site 381764004103 phosphorylation site [posttranslational modification] 381764004104 intermolecular recognition site; other site 381764004105 dimerization interface [polypeptide binding]; other site 381764004106 LytTr DNA-binding domain; Region: LytTR; smart00850 381764004107 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 381764004108 Histidine kinase; Region: His_kinase; pfam06580 381764004109 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 381764004110 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 381764004111 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 381764004112 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 381764004113 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 381764004114 MutS domain I; Region: MutS_I; pfam01624 381764004115 MutS domain II; Region: MutS_II; pfam05188 381764004116 MutS domain III; Region: MutS_III; pfam05192 381764004117 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 381764004118 Walker A/P-loop; other site 381764004119 ATP binding site [chemical binding]; other site 381764004120 Q-loop/lid; other site 381764004121 ABC transporter signature motif; other site 381764004122 Walker B; other site 381764004123 D-loop; other site 381764004124 H-loop/switch region; other site 381764004125 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 381764004126 Glycoprotease family; Region: Peptidase_M22; pfam00814 381764004127 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 381764004128 fructuronate transporter; Provisional; Region: PRK10034; cl15264 381764004129 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 381764004130 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 381764004131 MOFRL family; Region: MOFRL; pfam05161 381764004132 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 381764004133 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 381764004134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764004135 catalytic residue [active] 381764004136 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 381764004137 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 381764004138 Walker A/P-loop; other site 381764004139 ATP binding site [chemical binding]; other site 381764004140 Q-loop/lid; other site 381764004141 ABC transporter signature motif; other site 381764004142 Walker B; other site 381764004143 D-loop; other site 381764004144 H-loop/switch region; other site 381764004145 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 381764004146 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 381764004147 Walker A/P-loop; other site 381764004148 ATP binding site [chemical binding]; other site 381764004149 Q-loop/lid; other site 381764004150 ABC transporter signature motif; other site 381764004151 Walker B; other site 381764004152 D-loop; other site 381764004153 H-loop/switch region; other site 381764004154 Cobalt transport protein; Region: CbiQ; cl00463 381764004155 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 381764004156 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 381764004157 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 381764004158 Walker A/P-loop; other site 381764004159 ATP binding site [chemical binding]; other site 381764004160 Q-loop/lid; other site 381764004161 ABC transporter signature motif; other site 381764004162 Walker B; other site 381764004163 D-loop; other site 381764004164 H-loop/switch region; other site 381764004165 FeS assembly protein SufB; Region: sufB; TIGR01980 381764004166 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 381764004167 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 381764004168 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764004169 Integrase core domain; Region: rve; pfam00665 381764004170 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 381764004171 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 381764004172 putative ligand binding pocket/active site [active] 381764004173 putative metal binding site [ion binding]; other site 381764004174 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 381764004175 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 381764004176 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 381764004177 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381764004178 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 381764004179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 381764004180 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 381764004181 Walker A/P-loop; other site 381764004182 ATP binding site [chemical binding]; other site 381764004183 Q-loop/lid; other site 381764004184 ABC transporter signature motif; other site 381764004185 Walker B; other site 381764004186 D-loop; other site 381764004187 H-loop/switch region; other site 381764004188 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 381764004189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764004190 S-adenosylmethionine binding site [chemical binding]; other site 381764004191 GAF domain; Region: GAF; cl17456 381764004192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764004193 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764004194 metal binding site [ion binding]; metal-binding site 381764004195 active site 381764004196 I-site; other site 381764004197 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 381764004198 PAS domain S-box; Region: sensory_box; TIGR00229 381764004199 PAS domain S-box; Region: sensory_box; TIGR00229 381764004200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764004201 putative active site [active] 381764004202 heme pocket [chemical binding]; other site 381764004203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381764004204 dimer interface [polypeptide binding]; other site 381764004205 phosphorylation site [posttranslational modification] 381764004206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764004207 ATP binding site [chemical binding]; other site 381764004208 Mg2+ binding site [ion binding]; other site 381764004209 G-X-G motif; other site 381764004210 Response regulator receiver domain; Region: Response_reg; pfam00072 381764004211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764004212 active site 381764004213 phosphorylation site [posttranslational modification] 381764004214 intermolecular recognition site; other site 381764004215 dimerization interface [polypeptide binding]; other site 381764004216 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 381764004217 putative binding surface; other site 381764004218 active site 381764004219 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 381764004220 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 381764004221 FAD binding site [chemical binding]; other site 381764004222 hypothetical protein; Provisional; Region: PRK04334 381764004223 Domain of unknown function DUF39; Region: DUF39; pfam01837 381764004224 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 381764004225 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 381764004226 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 381764004227 nucleotide binding site [chemical binding]; other site 381764004228 substrate binding site [chemical binding]; other site 381764004229 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 381764004230 Acylphosphatase; Region: Acylphosphatase; pfam00708 381764004231 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 381764004232 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 381764004233 GDP-binding site [chemical binding]; other site 381764004234 ACT binding site; other site 381764004235 IMP binding site; other site 381764004236 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 381764004237 Uncharacterized conserved protein [Function unknown]; Region: COG1656 381764004238 Protein of unknown function DUF82; Region: DUF82; pfam01927 381764004239 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 381764004240 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 381764004241 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 381764004242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764004243 FeS/SAM binding site; other site 381764004244 TRAM domain; Region: TRAM; cl01282 381764004245 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 381764004246 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 381764004247 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 381764004248 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 381764004249 recombinase A; Provisional; Region: recA; PRK09354 381764004250 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 381764004251 hexamer interface [polypeptide binding]; other site 381764004252 Walker A motif; other site 381764004253 ATP binding site [chemical binding]; other site 381764004254 Walker B motif; other site 381764004255 RecX family; Region: RecX; cl00936 381764004256 KH domain; Region: KH_1; pfam00013 381764004257 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 381764004258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764004259 Zn2+ binding site [ion binding]; other site 381764004260 Mg2+ binding site [ion binding]; other site 381764004261 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 381764004262 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 381764004263 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 381764004264 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 381764004265 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 381764004266 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 381764004267 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 381764004268 Protein of unknown function (DUF523); Region: DUF523; pfam04463 381764004269 Uncharacterized conserved protein [Function unknown]; Region: COG3272 381764004270 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 381764004271 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 381764004272 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 381764004273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 381764004274 active site 381764004275 metal binding site [ion binding]; metal-binding site 381764004276 PQQ-like domain; Region: PQQ_2; pfam13360 381764004277 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 381764004278 Trp docking motif [polypeptide binding]; other site 381764004279 active site 381764004280 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 381764004281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 381764004282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764004283 dimer interface [polypeptide binding]; other site 381764004284 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 381764004285 putative CheW interface [polypeptide binding]; other site 381764004286 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 381764004287 active site 381764004288 catalytic triad [active] 381764004289 oxyanion hole [active] 381764004290 hydroxylamine reductase; Provisional; Region: PRK12310 381764004291 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 381764004292 cubane metal cluster [ion binding]; other site 381764004293 hybrid metal cluster; other site 381764004294 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 381764004295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381764004296 ligand binding site [chemical binding]; other site 381764004297 flexible hinge region; other site 381764004298 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 381764004299 putative switch regulator; other site 381764004300 non-specific DNA interactions [nucleotide binding]; other site 381764004301 DNA binding site [nucleotide binding] 381764004302 sequence specific DNA binding site [nucleotide binding]; other site 381764004303 putative cAMP binding site [chemical binding]; other site 381764004304 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381764004305 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381764004306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764004307 Walker A/P-loop; other site 381764004308 ATP binding site [chemical binding]; other site 381764004309 Q-loop/lid; other site 381764004310 ABC transporter signature motif; other site 381764004311 Walker B; other site 381764004312 D-loop; other site 381764004313 H-loop/switch region; other site 381764004314 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 381764004315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 381764004316 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 381764004317 Walker A/P-loop; other site 381764004318 ATP binding site [chemical binding]; other site 381764004319 Q-loop/lid; other site 381764004320 ABC transporter signature motif; other site 381764004321 Walker B; other site 381764004322 D-loop; other site 381764004323 H-loop/switch region; other site 381764004324 Threonine dehydrogenase; Region: TDH; cd05281 381764004325 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 381764004326 structural Zn binding site [ion binding]; other site 381764004327 catalytic Zn binding site [ion binding]; other site 381764004328 tetramer interface [polypeptide binding]; other site 381764004329 NADP binding site [chemical binding]; other site 381764004330 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 381764004331 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 381764004332 substrate-cofactor binding pocket; other site 381764004333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764004334 catalytic residue [active] 381764004335 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 381764004336 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381764004337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 381764004338 ligand binding site [chemical binding]; other site 381764004339 flexible hinge region; other site 381764004340 isoaspartyl dipeptidase; Provisional; Region: PRK10657 381764004341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381764004342 active site 381764004343 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 381764004344 Ferredoxin [Energy production and conversion]; Region: COG1146 381764004345 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381764004346 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 381764004347 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 381764004348 dimer interface [polypeptide binding]; other site 381764004349 PYR/PP interface [polypeptide binding]; other site 381764004350 TPP binding site [chemical binding]; other site 381764004351 substrate binding site [chemical binding]; other site 381764004352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381764004353 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 381764004354 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 381764004355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 381764004356 nucleotide binding region [chemical binding]; other site 381764004357 ATP-binding site [chemical binding]; other site 381764004358 Domain of unknown function DUF59; Region: DUF59; cl00941 381764004359 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 381764004360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 381764004361 ligand binding site [chemical binding]; other site 381764004362 flexible hinge region; other site 381764004363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 381764004364 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 381764004365 dimer interface [polypeptide binding]; other site 381764004366 substrate binding site [chemical binding]; other site 381764004367 metal binding site [ion binding]; metal-binding site 381764004368 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 381764004369 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 381764004370 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 381764004371 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 381764004372 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 381764004373 carboxyltransferase (CT) interaction site; other site 381764004374 biotinylation site [posttranslational modification]; other site 381764004375 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 381764004376 NAD(P) binding pocket [chemical binding]; other site 381764004377 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 381764004378 ArgK protein; Region: ArgK; pfam03308 381764004379 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 381764004380 Walker A; other site 381764004381 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 381764004382 Switch II region; other site 381764004383 G4 box; other site 381764004384 G5 box; other site 381764004385 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 381764004386 B12 binding site [chemical binding]; other site 381764004387 cobalt ligand [ion binding]; other site 381764004388 CodY GAF-like domain; Region: CodY; pfam06018 381764004389 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 381764004390 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 381764004391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 381764004392 non-specific DNA binding site [nucleotide binding]; other site 381764004393 salt bridge; other site 381764004394 sequence-specific DNA binding site [nucleotide binding]; other site 381764004395 Cupin domain; Region: Cupin_2; pfam07883 381764004396 spermidine synthase; Provisional; Region: PRK00811 381764004397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764004398 S-adenosylmethionine binding site [chemical binding]; other site 381764004399 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 381764004400 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 381764004401 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 381764004402 Predicted methyltransferases [General function prediction only]; Region: COG0313 381764004403 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 381764004404 putative SAM binding site [chemical binding]; other site 381764004405 putative homodimer interface [polypeptide binding]; other site 381764004406 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 381764004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764004408 S-adenosylmethionine binding site [chemical binding]; other site 381764004409 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 381764004410 PGAP1-like protein; Region: PGAP1; pfam07819 381764004411 Protein of unknown function (DUF3242); Region: DUF3242; pfam11586 381764004412 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 381764004413 RNA/DNA hybrid binding site [nucleotide binding]; other site 381764004414 active site 381764004415 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 381764004416 DRTGG domain; Region: DRTGG; pfam07085 381764004417 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 381764004418 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 381764004419 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 381764004420 homodimer interface [polypeptide binding]; other site 381764004421 NADP binding site [chemical binding]; other site 381764004422 substrate binding site [chemical binding]; other site 381764004423 Preprotein translocase subunit; Region: YajC; cl00806 381764004424 protein-export membrane protein SecD; Region: secD; TIGR01129 381764004425 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 381764004426 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 381764004427 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 381764004428 Protein export membrane protein; Region: SecD_SecF; pfam02355 381764004429 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 381764004430 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 381764004431 6-phosphofructokinase; Provisional; Region: PRK03202 381764004432 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 381764004433 active site 381764004434 ADP/pyrophosphate binding site [chemical binding]; other site 381764004435 dimerization interface [polypeptide binding]; other site 381764004436 allosteric effector site; other site 381764004437 fructose-1,6-bisphosphate binding site; other site 381764004438 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 381764004439 MFS/sugar transport protein; Region: MFS_2; pfam13347 381764004440 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 381764004441 putative active site; other site 381764004442 putative metal binding residues [ion binding]; other site 381764004443 signature motif; other site 381764004444 putative triphosphate binding site [ion binding]; other site 381764004445 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 381764004446 metal-binding site [ion binding] 381764004447 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 381764004448 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381764004449 metal-binding site [ion binding] 381764004450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 381764004451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764004452 motif II; other site 381764004453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764004454 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764004455 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 381764004456 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764004457 metal binding site [ion binding]; metal-binding site 381764004458 active site 381764004459 I-site; other site 381764004460 GAF domain; Region: GAF; pfam01590 381764004461 GAF domain; Region: GAF_2; pfam13185 381764004462 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 381764004463 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 381764004464 putative substrate binding site [chemical binding]; other site 381764004465 putative ATP binding site [chemical binding]; other site 381764004466 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 381764004467 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 381764004468 NAD binding site [chemical binding]; other site 381764004469 sugar binding site [chemical binding]; other site 381764004470 divalent metal binding site [ion binding]; other site 381764004471 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 381764004472 dimer interface [polypeptide binding]; other site 381764004473 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764004474 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764004475 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 381764004476 FOG: WD40 repeat [General function prediction only]; Region: COG2319 381764004477 structural tetrad; other site 381764004478 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 381764004479 AAA domain; Region: AAA_11; pfam13086 381764004480 Part of AAA domain; Region: AAA_19; pfam13245 381764004481 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 381764004482 AAA domain; Region: AAA_12; pfam13087 381764004483 RAP domain; Region: RAP; pfam08373 381764004484 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 381764004485 Protein of unknown function DUF58; Region: DUF58; pfam01882 381764004486 MoxR-like ATPases [General function prediction only]; Region: COG0714 381764004487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764004488 Walker A motif; other site 381764004489 ATP binding site [chemical binding]; other site 381764004490 Walker B motif; other site 381764004491 arginine finger; other site 381764004492 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764004493 Integrase core domain; Region: rve; pfam00665 381764004494 recombination protein F; Reviewed; Region: recF; PRK00064 381764004495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764004496 Walker A/P-loop; other site 381764004497 ATP binding site [chemical binding]; other site 381764004498 Q-loop/lid; other site 381764004499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764004500 ABC transporter signature motif; other site 381764004501 Walker B; other site 381764004502 D-loop; other site 381764004503 reverse gyrase; Reviewed; Region: PRK09401 381764004504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764004505 ATP binding site [chemical binding]; other site 381764004506 putative Mg++ binding site [ion binding]; other site 381764004507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764004508 nucleotide binding region [chemical binding]; other site 381764004509 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 381764004510 active site 381764004511 metal binding site [ion binding]; metal-binding site 381764004512 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 381764004513 domain I; other site 381764004514 DNA binding groove [nucleotide binding] 381764004515 phosphate binding site [ion binding]; other site 381764004516 domain II; other site 381764004517 domain III; other site 381764004518 nucleotide binding site [chemical binding]; other site 381764004519 catalytic site [active] 381764004520 domain IV; other site 381764004521 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 381764004522 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381764004523 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 381764004524 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 381764004525 putative dimer interface [polypeptide binding]; other site 381764004526 active site pocket [active] 381764004527 putative cataytic base [active] 381764004528 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 381764004529 homotrimer interface [polypeptide binding]; other site 381764004530 Walker A motif; other site 381764004531 GTP binding site [chemical binding]; other site 381764004532 Walker B motif; other site 381764004533 cobalamin synthase; Reviewed; Region: cobS; PRK00235 381764004534 AAA domain; Region: AAA_26; pfam13500 381764004535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381764004536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 381764004537 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 381764004538 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 381764004539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 381764004540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 381764004541 homodimer interface [polypeptide binding]; other site 381764004542 catalytic residue [active] 381764004543 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 381764004544 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 381764004545 Ligand Binding Site [chemical binding]; other site 381764004546 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 381764004547 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 381764004548 homodimer interface [polypeptide binding]; other site 381764004549 Walker A motif; other site 381764004550 ATP binding site [chemical binding]; other site 381764004551 hydroxycobalamin binding site [chemical binding]; other site 381764004552 Walker B motif; other site 381764004553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 381764004554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 381764004555 active site 381764004556 catalytic tetrad [active] 381764004557 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 381764004558 diiron binding motif [ion binding]; other site 381764004559 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 381764004560 nudix motif; other site 381764004561 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 381764004562 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 381764004563 CoA-ligase; Region: Ligase_CoA; pfam00549 381764004564 CoA binding domain; Region: CoA_binding; smart00881 381764004565 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 381764004566 CoA-ligase; Region: Ligase_CoA; pfam00549 381764004567 Uncharacterized conserved protein [Function unknown]; Region: COG1284 381764004568 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 381764004569 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 381764004570 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 381764004571 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 381764004572 Ferritin-like domain; Region: Ferritin; pfam00210 381764004573 ferroxidase diiron center [ion binding]; other site 381764004574 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 381764004575 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 381764004576 dimer interface [polypeptide binding]; other site 381764004577 catalytic triad [active] 381764004578 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 381764004579 DNA photolyase; Region: DNA_photolyase; pfam00875 381764004580 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 381764004581 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 381764004582 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 381764004583 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 381764004584 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 381764004585 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 381764004586 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 381764004587 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 381764004588 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 381764004589 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 381764004590 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 381764004591 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 381764004592 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 381764004593 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 381764004594 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 381764004595 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 381764004596 active site 381764004597 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 381764004598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764004599 ATP binding site [chemical binding]; other site 381764004600 putative Mg++ binding site [ion binding]; other site 381764004601 helicase superfamily c-terminal domain; Region: HELICc; smart00490 381764004602 nucleotide binding region [chemical binding]; other site 381764004603 ATP-binding site [chemical binding]; other site 381764004604 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 381764004605 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 381764004606 PLD-like domain; Region: PLDc_2; pfam13091 381764004607 putative homodimer interface [polypeptide binding]; other site 381764004608 putative active site [active] 381764004609 catalytic site [active] 381764004610 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 381764004611 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 381764004612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764004613 nucleotide binding region [chemical binding]; other site 381764004614 ATP-binding site [chemical binding]; other site 381764004615 Methyltransferase domain; Region: Methyltransf_23; pfam13489 381764004616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764004617 S-adenosylmethionine binding site [chemical binding]; other site 381764004618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 381764004619 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764004620 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 381764004621 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764004622 Integrase core domain; Region: rve; pfam00665 381764004623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 381764004624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764004625 TPR motif; other site 381764004626 binding surface 381764004627 TPR repeat; Region: TPR_11; pfam13414 381764004628 TPR repeat; Region: TPR_11; pfam13414 381764004629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764004630 binding surface 381764004631 TPR motif; other site 381764004632 benzoate transport; Region: 2A0115; TIGR00895 381764004633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 381764004634 putative substrate translocation pore; other site 381764004635 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 381764004636 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 381764004637 catalytic motif [active] 381764004638 Zn binding site [ion binding]; other site 381764004639 RibD C-terminal domain; Region: RibD_C; pfam01872 381764004640 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 381764004641 Lumazine binding domain; Region: Lum_binding; pfam00677 381764004642 Lumazine binding domain; Region: Lum_binding; pfam00677 381764004643 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09318 381764004644 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 381764004645 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 381764004646 dimerization interface [polypeptide binding]; other site 381764004647 active site 381764004648 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 381764004649 homopentamer interface [polypeptide binding]; other site 381764004650 active site 381764004651 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 381764004652 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 381764004653 substrate binding site [chemical binding]; other site 381764004654 ATP binding site [chemical binding]; other site 381764004655 Putative aldolase; Region: Aldolase_2; pfam10120 381764004656 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 381764004657 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 381764004658 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 381764004659 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 381764004660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764004661 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 381764004662 nucleotide binding site/active site [active] 381764004663 HIT family signature motif; other site 381764004664 catalytic residue [active] 381764004665 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 381764004666 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 381764004667 HIGH motif; other site 381764004668 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 381764004669 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 381764004670 active site 381764004671 KMSKS motif; other site 381764004672 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 381764004673 tRNA binding surface [nucleotide binding]; other site 381764004674 anticodon binding site; other site 381764004675 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 381764004676 Response regulator receiver domain; Region: Response_reg; pfam00072 381764004677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764004678 active site 381764004679 phosphorylation site [posttranslational modification] 381764004680 intermolecular recognition site; other site 381764004681 dimerization interface [polypeptide binding]; other site 381764004682 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 381764004683 carbohydrate binding site [chemical binding]; other site 381764004684 pullulanase, type I; Region: pulA_typeI; TIGR02104 381764004685 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 381764004686 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 381764004687 Ca binding site [ion binding]; other site 381764004688 active site 381764004689 catalytic site [active] 381764004690 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 381764004691 PBP superfamily domain; Region: PBP_like_2; cl17296 381764004692 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 381764004693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764004694 dimer interface [polypeptide binding]; other site 381764004695 conserved gate region; other site 381764004696 putative PBP binding loops; other site 381764004697 ABC-ATPase subunit interface; other site 381764004698 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 381764004699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764004700 dimer interface [polypeptide binding]; other site 381764004701 conserved gate region; other site 381764004702 putative PBP binding loops; other site 381764004703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381764004704 ABC-ATPase subunit interface; other site 381764004705 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 381764004706 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 381764004707 Walker A/P-loop; other site 381764004708 ATP binding site [chemical binding]; other site 381764004709 Q-loop/lid; other site 381764004710 ABC transporter signature motif; other site 381764004711 Walker B; other site 381764004712 D-loop; other site 381764004713 H-loop/switch region; other site 381764004714 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 381764004715 PhoU domain; Region: PhoU; pfam01895 381764004716 PhoU domain; Region: PhoU; pfam01895 381764004717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381764004718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764004719 active site 381764004720 phosphorylation site [posttranslational modification] 381764004721 intermolecular recognition site; other site 381764004722 dimerization interface [polypeptide binding]; other site 381764004723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381764004724 DNA binding site [nucleotide binding] 381764004725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764004726 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764004727 Cache domain; Region: Cache_1; pfam02743 381764004728 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 381764004729 dimerization interface [polypeptide binding]; other site 381764004730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 381764004731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 381764004732 dimer interface [polypeptide binding]; other site 381764004733 putative CheW interface [polypeptide binding]; other site 381764004734 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 381764004735 Bacterial sugar transferase; Region: Bac_transf; pfam02397 381764004736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764004737 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764004738 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381764004739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 381764004740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764004741 ATP binding site [chemical binding]; other site 381764004742 Mg2+ binding site [ion binding]; other site 381764004743 G-X-G motif; other site 381764004744 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 381764004745 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 381764004746 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 381764004747 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 381764004748 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 381764004749 G1 box; other site 381764004750 putative GEF interaction site [polypeptide binding]; other site 381764004751 GTP/Mg2+ binding site [chemical binding]; other site 381764004752 Switch I region; other site 381764004753 G2 box; other site 381764004754 G3 box; other site 381764004755 Switch II region; other site 381764004756 G4 box; other site 381764004757 G5 box; other site 381764004758 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 381764004759 Translation-initiation factor 2; Region: IF-2; pfam11987 381764004760 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 381764004761 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 381764004762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 381764004763 NAD(P) binding site [chemical binding]; other site 381764004764 active site 381764004765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 381764004766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381764004767 putative DNA binding site [nucleotide binding]; other site 381764004768 putative Zn2+ binding site [ion binding]; other site 381764004769 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 381764004770 active site 381764004771 metal-binding site [ion binding] 381764004772 nucleotide-binding site [chemical binding]; other site 381764004773 peroxiredoxin; Provisional; Region: PRK13189 381764004774 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 381764004775 dimer interface [polypeptide binding]; other site 381764004776 decamer (pentamer of dimers) interface [polypeptide binding]; other site 381764004777 catalytic triad [active] 381764004778 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 381764004779 homodimer interface [polypeptide binding]; other site 381764004780 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 381764004781 active site pocket [active] 381764004782 Uncharacterized conserved protein [Function unknown]; Region: COG1433 381764004783 Predicted transcriptional regulators [Transcription]; Region: COG1695 381764004784 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 381764004785 glutamine synthetase, type I; Region: GlnA; TIGR00653 381764004786 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 381764004787 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 381764004788 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 381764004789 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 381764004790 substrate binding site; other site 381764004791 metal-binding site 381764004792 Oligomer interface; other site 381764004793 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 381764004794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764004795 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 381764004796 active site 381764004797 motif I; other site 381764004798 motif II; other site 381764004799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 381764004800 motif II; other site 381764004801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764004802 TPR motif; other site 381764004803 binding surface 381764004804 TPR repeat; Region: TPR_11; pfam13414 381764004805 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 381764004806 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 381764004807 dimer interface [polypeptide binding]; other site 381764004808 motif 1; other site 381764004809 active site 381764004810 motif 2; other site 381764004811 motif 3; other site 381764004812 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 381764004813 anticodon binding site; other site 381764004814 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 381764004815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764004816 UDP-galactopyranose mutase; Region: GLF; pfam03275 381764004817 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 381764004818 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381764004819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 381764004820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 381764004821 active site 381764004822 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 381764004823 Repair protein; Region: Repair_PSII; pfam04536 381764004824 urocanate hydratase; Provisional; Region: PRK05414 381764004825 MoxR-like ATPases [General function prediction only]; Region: COG0714 381764004826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 381764004827 Walker A motif; other site 381764004828 ATP binding site [chemical binding]; other site 381764004829 Walker B motif; other site 381764004830 arginine finger; other site 381764004831 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 381764004832 ScpA/B protein; Region: ScpA_ScpB; cl00598 381764004833 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 381764004834 FOG: CBS domain [General function prediction only]; Region: COG0517 381764004835 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 381764004836 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 381764004837 Flavoprotein; Region: Flavoprotein; pfam02441 381764004838 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 381764004839 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 381764004840 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 381764004841 putative ligand binding site [chemical binding]; other site 381764004842 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 381764004843 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 381764004844 putative ligand binding site [chemical binding]; other site 381764004845 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381764004846 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 381764004847 TM-ABC transporter signature motif; other site 381764004848 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 381764004849 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 381764004850 TM-ABC transporter signature motif; other site 381764004851 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 381764004852 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 381764004853 Walker A/P-loop; other site 381764004854 ATP binding site [chemical binding]; other site 381764004855 Q-loop/lid; other site 381764004856 ABC transporter signature motif; other site 381764004857 Walker B; other site 381764004858 D-loop; other site 381764004859 H-loop/switch region; other site 381764004860 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 381764004861 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 381764004862 Walker A/P-loop; other site 381764004863 ATP binding site [chemical binding]; other site 381764004864 Q-loop/lid; other site 381764004865 ABC transporter signature motif; other site 381764004866 Walker B; other site 381764004867 D-loop; other site 381764004868 H-loop/switch region; other site 381764004869 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 381764004870 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 381764004871 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 381764004872 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 381764004873 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 381764004874 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 381764004875 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381764004876 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 381764004877 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 381764004878 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 381764004879 putative metal binding site; other site 381764004880 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 381764004881 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381764004882 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 381764004883 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 381764004884 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381764004885 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 381764004886 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 381764004887 putative trimer interface [polypeptide binding]; other site 381764004888 putative CoA binding site [chemical binding]; other site 381764004889 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 381764004890 putative trimer interface [polypeptide binding]; other site 381764004891 putative active site [active] 381764004892 putative substrate binding site [chemical binding]; other site 381764004893 putative CoA binding site [chemical binding]; other site 381764004894 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 381764004895 active site 381764004896 dimer interfaces [polypeptide binding]; other site 381764004897 catalytic residues [active] 381764004898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 381764004899 Domain of unknown function DUF20; Region: UPF0118; pfam01594 381764004900 Tetratricopeptide repeat; Region: TPR_16; pfam13432 381764004901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764004902 TPR motif; other site 381764004903 binding surface 381764004904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764004905 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 381764004906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764004907 S-adenosylmethionine binding site [chemical binding]; other site 381764004908 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 381764004909 Predicted permeases [General function prediction only]; Region: COG0701 381764004910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381764004911 dimerization interface [polypeptide binding]; other site 381764004912 putative DNA binding site [nucleotide binding]; other site 381764004913 putative Zn2+ binding site [ion binding]; other site 381764004914 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 381764004915 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 381764004916 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 381764004917 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 381764004918 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 381764004919 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 381764004920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 381764004921 putative active site [active] 381764004922 heme pocket [chemical binding]; other site 381764004923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 381764004924 dimer interface [polypeptide binding]; other site 381764004925 phosphorylation site [posttranslational modification] 381764004926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764004927 ATP binding site [chemical binding]; other site 381764004928 Mg2+ binding site [ion binding]; other site 381764004929 G-X-G motif; other site 381764004930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 381764004931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764004932 active site 381764004933 phosphorylation site [posttranslational modification] 381764004934 intermolecular recognition site; other site 381764004935 dimerization interface [polypeptide binding]; other site 381764004936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 381764004937 DNA binding site [nucleotide binding] 381764004938 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 381764004939 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 381764004940 dimerization interface [polypeptide binding]; other site 381764004941 domain crossover interface; other site 381764004942 redox-dependent activation switch; other site 381764004943 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 381764004944 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 381764004945 NAD(P) binding site [chemical binding]; other site 381764004946 homodimer interface [polypeptide binding]; other site 381764004947 substrate binding site [chemical binding]; other site 381764004948 active site 381764004949 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 381764004950 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 381764004951 hinge; other site 381764004952 active site 381764004953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 381764004954 metal binding site [ion binding]; metal-binding site 381764004955 active site 381764004956 I-site; other site 381764004957 rod shape-determining protein MreB; Provisional; Region: PRK13930 381764004958 MreB and similar proteins; Region: MreB_like; cd10225 381764004959 nucleotide binding site [chemical binding]; other site 381764004960 Mg binding site [ion binding]; other site 381764004961 putative protofilament interaction site [polypeptide binding]; other site 381764004962 RodZ interaction site [polypeptide binding]; other site 381764004963 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 381764004964 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 381764004965 motif 1; other site 381764004966 active site 381764004967 motif 2; other site 381764004968 motif 3; other site 381764004969 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 381764004970 DHHA1 domain; Region: DHHA1; pfam02272 381764004971 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 381764004972 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 381764004973 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 381764004974 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 381764004975 catalytic residue [active] 381764004976 putative FPP diphosphate binding site; other site 381764004977 putative FPP binding hydrophobic cleft; other site 381764004978 dimer interface [polypeptide binding]; other site 381764004979 putative IPP diphosphate binding site; other site 381764004980 ribosome recycling factor; Reviewed; Region: frr; PRK00083 381764004981 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 381764004982 hinge region; other site 381764004983 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 381764004984 homotrimer interaction site [polypeptide binding]; other site 381764004985 zinc binding site [ion binding]; other site 381764004986 CDP-binding sites; other site 381764004987 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 381764004988 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 381764004989 ligand binding site; other site 381764004990 oligomer interface; other site 381764004991 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 381764004992 dimer interface [polypeptide binding]; other site 381764004993 N-terminal domain interface [polypeptide binding]; other site 381764004994 sulfate 1 binding site; other site 381764004995 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 381764004996 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 381764004997 ligand binding site; other site 381764004998 oligomer interface; other site 381764004999 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 381764005000 N-terminal domain interface [polypeptide binding]; other site 381764005001 sulfate 1 binding site; other site 381764005002 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 381764005003 intersubunit interface [polypeptide binding]; other site 381764005004 active site 381764005005 catalytic residue [active] 381764005006 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 381764005007 SmpB-tmRNA interface; other site 381764005008 hypothetical protein; Reviewed; Region: PRK12497 381764005009 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 381764005010 Global regulator protein family; Region: CsrA; pfam02599 381764005011 flagellar assembly protein FliW; Provisional; Region: PRK13285 381764005012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 381764005013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 381764005014 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 381764005015 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 381764005016 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 381764005017 DAK2 domain; Region: Dak2; pfam02734 381764005018 Asp23 family; Region: Asp23; pfam03780 381764005019 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 381764005020 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 381764005021 TPP-binding site; other site 381764005022 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 381764005023 PYR/PP interface [polypeptide binding]; other site 381764005024 dimer interface [polypeptide binding]; other site 381764005025 TPP binding site [chemical binding]; other site 381764005026 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381764005027 seryl-tRNA synthetase; Provisional; Region: PRK05431 381764005028 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 381764005029 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 381764005030 dimer interface [polypeptide binding]; other site 381764005031 active site 381764005032 motif 1; other site 381764005033 motif 2; other site 381764005034 motif 3; other site 381764005035 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 381764005036 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 381764005037 Ion channel; Region: Ion_trans_2; pfam07885 381764005038 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 381764005039 TrkA-N domain; Region: TrkA_N; pfam02254 381764005040 TrkA-C domain; Region: TrkA_C; pfam02080 381764005041 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 381764005042 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 381764005043 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 381764005044 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 381764005045 HIGH motif; other site 381764005046 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 381764005047 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 381764005048 active site 381764005049 KMSKS motif; other site 381764005050 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 381764005051 tRNA binding surface [nucleotide binding]; other site 381764005052 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 381764005053 MgtE intracellular N domain; Region: MgtE_N; smart00924 381764005054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 381764005055 Divalent cation transporter; Region: MgtE; pfam01769 381764005056 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 381764005057 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 381764005058 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 381764005059 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 381764005060 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 381764005061 active site 381764005062 dimerization interface [polypeptide binding]; other site 381764005063 imidazolonepropionase; Validated; Region: PRK09356 381764005064 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 381764005065 active site 381764005066 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 381764005067 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 381764005068 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 381764005069 beta-galactosidase; Region: BGL; TIGR03356 381764005070 flagellar motor switch protein; Validated; Region: PRK08119 381764005071 CheC-like family; Region: CheC; pfam04509 381764005072 CheC-like family; Region: CheC; pfam04509 381764005073 flagellar motor switch protein FliN; Region: fliN; TIGR02480 381764005074 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 381764005075 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 381764005076 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 381764005077 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 381764005078 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 381764005079 ligand binding site [chemical binding]; other site 381764005080 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 381764005081 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 381764005082 Flagellar protein (FlbD); Region: FlbD; pfam06289 381764005083 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 381764005084 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381764005085 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 381764005086 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 381764005087 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 381764005088 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 381764005089 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 381764005090 elongation factor G; Reviewed; Region: PRK12740 381764005091 G1 box; other site 381764005092 putative GEF interaction site [polypeptide binding]; other site 381764005093 GTP/Mg2+ binding site [chemical binding]; other site 381764005094 Switch I region; other site 381764005095 G2 box; other site 381764005096 G3 box; other site 381764005097 Switch II region; other site 381764005098 G4 box; other site 381764005099 G5 box; other site 381764005100 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 381764005101 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 381764005102 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 381764005103 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 381764005104 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 381764005105 NADP+ binding site [chemical binding]; other site 381764005106 folate binding site [chemical binding]; other site 381764005107 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 381764005108 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 381764005109 ring oligomerisation interface [polypeptide binding]; other site 381764005110 ATP/Mg binding site [chemical binding]; other site 381764005111 stacking interactions; other site 381764005112 hinge regions; other site 381764005113 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 381764005114 oligomerisation interface [polypeptide binding]; other site 381764005115 mobile loop; other site 381764005116 roof hairpin; other site 381764005117 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 381764005118 6-phosphofructokinase; Provisional; Region: PRK14072 381764005119 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 381764005120 active site 381764005121 ADP/pyrophosphate binding site [chemical binding]; other site 381764005122 dimerization interface [polypeptide binding]; other site 381764005123 allosteric effector site; other site 381764005124 fructose-1,6-bisphosphate binding site; other site 381764005125 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381764005126 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 381764005127 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 381764005128 Interdomain contacts; other site 381764005129 Cytokine receptor motif; other site 381764005130 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381764005131 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 381764005132 substrate binding site [chemical binding]; other site 381764005133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 381764005134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764005135 dimer interface [polypeptide binding]; other site 381764005136 conserved gate region; other site 381764005137 putative PBP binding loops; other site 381764005138 ABC-ATPase subunit interface; other site 381764005139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 381764005140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764005141 dimer interface [polypeptide binding]; other site 381764005142 conserved gate region; other site 381764005143 putative PBP binding loops; other site 381764005144 ABC-ATPase subunit interface; other site 381764005145 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 381764005146 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764005147 Walker A/P-loop; other site 381764005148 ATP binding site [chemical binding]; other site 381764005149 Q-loop/lid; other site 381764005150 ABC transporter signature motif; other site 381764005151 Walker B; other site 381764005152 D-loop; other site 381764005153 H-loop/switch region; other site 381764005154 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764005155 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 381764005156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764005157 Walker A/P-loop; other site 381764005158 ATP binding site [chemical binding]; other site 381764005159 Q-loop/lid; other site 381764005160 ABC transporter signature motif; other site 381764005161 Walker B; other site 381764005162 D-loop; other site 381764005163 H-loop/switch region; other site 381764005164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 381764005165 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 381764005166 beta-galactosidase; Region: BGL; TIGR03356 381764005167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381764005168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381764005169 DNA binding site [nucleotide binding] 381764005170 domain linker motif; other site 381764005171 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 381764005172 dimerization interface [polypeptide binding]; other site 381764005173 ligand binding site [chemical binding]; other site 381764005174 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 381764005175 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 381764005176 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 381764005177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 381764005178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764005179 dimer interface [polypeptide binding]; other site 381764005180 conserved gate region; other site 381764005181 putative PBP binding loops; other site 381764005182 ABC-ATPase subunit interface; other site 381764005183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 381764005184 Transposase; Region: DDE_Tnp_ISL3; pfam01610 381764005185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 381764005186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764005187 dimer interface [polypeptide binding]; other site 381764005188 conserved gate region; other site 381764005189 putative PBP binding loops; other site 381764005190 ABC-ATPase subunit interface; other site 381764005191 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381764005192 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 381764005193 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 381764005194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764005195 Walker A/P-loop; other site 381764005196 ATP binding site [chemical binding]; other site 381764005197 Q-loop/lid; other site 381764005198 ABC transporter signature motif; other site 381764005199 Walker B; other site 381764005200 D-loop; other site 381764005201 H-loop/switch region; other site 381764005202 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764005203 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 381764005204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 381764005205 Walker A/P-loop; other site 381764005206 ATP binding site [chemical binding]; other site 381764005207 Q-loop/lid; other site 381764005208 ABC transporter signature motif; other site 381764005209 Walker B; other site 381764005210 D-loop; other site 381764005211 H-loop/switch region; other site 381764005212 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 381764005213 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 381764005214 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 381764005215 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 381764005216 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 381764005217 trimer interface [polypeptide binding]; other site 381764005218 active site 381764005219 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 381764005220 catalytic site [active] 381764005221 pantoate--beta-alanine ligase; Region: panC; TIGR00018 381764005222 Pantoate-beta-alanine ligase; Region: PanC; cd00560 381764005223 active site 381764005224 ATP-binding site [chemical binding]; other site 381764005225 pantoate-binding site; other site 381764005226 HXXH motif; other site 381764005227 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 381764005228 DNA protecting protein DprA; Region: dprA; TIGR00732 381764005229 Putative Fe-S cluster; Region: FeS; cl17515 381764005230 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764005231 Integrase core domain; Region: rve; pfam00665 381764005232 Predicted membrane protein [Function unknown]; Region: COG4267 381764005233 GAF domain; Region: GAF_3; pfam13492 381764005234 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 381764005235 FAD binding site [chemical binding]; other site 381764005236 primosomal protein N' Region: priA; TIGR00595 381764005237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764005238 ATP binding site [chemical binding]; other site 381764005239 putative Mg++ binding site [ion binding]; other site 381764005240 helicase superfamily c-terminal domain; Region: HELICc; smart00490 381764005241 ATP-binding site [chemical binding]; other site 381764005242 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 381764005243 Na2 binding site [ion binding]; other site 381764005244 substrate binding site 1 [chemical binding]; other site 381764005245 Na binding site 1 [ion binding]; other site 381764005246 substrate binding site 2 [chemical binding]; other site 381764005247 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764005248 Integrase core domain; Region: rve; pfam00665 381764005249 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 381764005250 CotH protein; Region: CotH; pfam08757 381764005251 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 381764005252 competence damage-inducible protein A; Provisional; Region: PRK00549 381764005253 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 381764005254 putative MPT binding site; other site 381764005255 Competence-damaged protein; Region: CinA; pfam02464 381764005256 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381764005257 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381764005258 DNA binding site [nucleotide binding] 381764005259 domain linker motif; other site 381764005260 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 381764005261 dimerization interface [polypeptide binding]; other site 381764005262 ligand binding site [chemical binding]; other site 381764005263 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 381764005264 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 381764005265 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381764005266 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 381764005267 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 381764005268 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 381764005269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 381764005270 Walker A/P-loop; other site 381764005271 ATP binding site [chemical binding]; other site 381764005272 Q-loop/lid; other site 381764005273 ABC transporter signature motif; other site 381764005274 Walker B; other site 381764005275 D-loop; other site 381764005276 H-loop/switch region; other site 381764005277 TOBE domain; Region: TOBE_2; pfam08402 381764005278 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764005279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 381764005280 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764005281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 381764005282 Tetratricopeptide repeat; Region: TPR_16; pfam13432 381764005283 binding surface 381764005284 TPR motif; other site 381764005285 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 381764005286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764005287 dimer interface [polypeptide binding]; other site 381764005288 conserved gate region; other site 381764005289 putative PBP binding loops; other site 381764005290 ABC-ATPase subunit interface; other site 381764005291 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 381764005292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 381764005293 dimer interface [polypeptide binding]; other site 381764005294 conserved gate region; other site 381764005295 ABC-ATPase subunit interface; other site 381764005296 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 381764005297 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 381764005298 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 381764005299 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 381764005300 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 381764005301 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 381764005302 active site 381764005303 catalytic residues [active] 381764005304 Transcriptional regulators [Transcription]; Region: PurR; COG1609 381764005305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 381764005306 DNA binding site [nucleotide binding] 381764005307 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 381764005308 dimerization interface [polypeptide binding]; other site 381764005309 ligand binding site [chemical binding]; other site 381764005310 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381764005311 ABC-2 type transporter; Region: ABC2_membrane; cl17235 381764005312 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 381764005313 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 381764005314 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 381764005315 Walker A/P-loop; other site 381764005316 ATP binding site [chemical binding]; other site 381764005317 Q-loop/lid; other site 381764005318 ABC transporter signature motif; other site 381764005319 Walker B; other site 381764005320 D-loop; other site 381764005321 H-loop/switch region; other site 381764005322 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 381764005323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764005324 FeS/SAM binding site; other site 381764005325 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 381764005326 putative oxidoreductase; Provisional; Region: PRK12831 381764005327 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 381764005328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 381764005329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 381764005330 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 381764005331 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 381764005332 FAD binding pocket [chemical binding]; other site 381764005333 FAD binding motif [chemical binding]; other site 381764005334 phosphate binding motif [ion binding]; other site 381764005335 beta-alpha-beta structure motif; other site 381764005336 NAD binding pocket [chemical binding]; other site 381764005337 Iron coordination center [ion binding]; other site 381764005338 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 381764005339 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 381764005340 catalytic residues [active] 381764005341 catalytic nucleophile [active] 381764005342 Recombinase; Region: Recombinase; pfam07508 381764005343 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 381764005344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 381764005345 dimerization interface [polypeptide binding]; other site 381764005346 putative DNA binding site [nucleotide binding]; other site 381764005347 putative Zn2+ binding site [ion binding]; other site 381764005348 Heavy-metal-associated domain; Region: HMA; pfam00403 381764005349 metal-binding site [ion binding] 381764005350 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 381764005351 metal-binding site [ion binding] 381764005352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 381764005354 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764005355 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 381764005356 glycogen binding site [chemical binding]; other site 381764005357 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 381764005358 glycogen binding site [chemical binding]; other site 381764005359 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 381764005360 putative ligand binding site [chemical binding]; other site 381764005361 Transposase; Region: HTH_Tnp_1; pfam01527 381764005362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 381764005363 HTH-like domain; Region: HTH_21; pfam13276 381764005364 Integrase core domain; Region: rve; pfam00665 381764005365 Integrase core domain; Region: rve_3; pfam13683 381764005366 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 381764005367 DDE domain; Region: DDE_Tnp_IS240; pfam13610 381764005368 CAAX protease self-immunity; Region: Abi; pfam02517 381764005369 Integrase core domain; Region: rve; pfam00665 381764005370 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 381764005371 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 381764005372 RNA/DNA hybrid binding site [nucleotide binding]; other site 381764005373 active site 381764005374 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 381764005375 RNA/DNA hybrid binding site [nucleotide binding]; other site 381764005376 active site 381764005377 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 381764005378 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764005379 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764005380 Transposase; Region: DEDD_Tnp_IS110; pfam01548 381764005381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 381764005382 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 381764005383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 381764005384 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 381764005385 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 381764005386 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 381764005387 active site 381764005388 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 381764005389 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 381764005390 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 381764005391 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 381764005392 Glutamate binding site [chemical binding]; other site 381764005393 homodimer interface [polypeptide binding]; other site 381764005394 NAD binding site [chemical binding]; other site 381764005395 catalytic residues [active] 381764005396 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 381764005397 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 381764005398 B12 binding site [chemical binding]; other site 381764005399 cobalt ligand [ion binding]; other site 381764005400 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 381764005401 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 381764005402 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 381764005403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 381764005404 catalytic residue [active] 381764005405 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 381764005406 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 381764005407 adenylosuccinate lyase; Provisional; Region: PRK07492 381764005408 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 381764005409 tetramer interface [polypeptide binding]; other site 381764005410 active site 381764005411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 381764005412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764005413 S-adenosylmethionine binding site [chemical binding]; other site 381764005414 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 381764005415 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 381764005416 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 381764005417 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381764005418 Vitamin-D-receptor interacting Mediator subunit 4; Region: Med4; pfam10018 381764005419 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381764005420 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 381764005421 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 381764005422 LabA_like proteins; Region: LabA_like; cd06167 381764005423 putative metal binding site [ion binding]; other site 381764005424 Uncharacterized conserved protein [Function unknown]; Region: COG1432 381764005425 Protein of unknown function (DUF501); Region: DUF501; pfam04417 381764005426 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 381764005427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764005428 S-adenosylmethionine binding site [chemical binding]; other site 381764005429 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 381764005430 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381764005431 Peptidase family M23; Region: Peptidase_M23; pfam01551 381764005432 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 381764005433 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 381764005434 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 381764005435 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 381764005436 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 381764005437 active site 381764005438 6-phosphofructokinase; Provisional; Region: PRK03202 381764005439 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 381764005440 active site 381764005441 ADP/pyrophosphate binding site [chemical binding]; other site 381764005442 dimerization interface [polypeptide binding]; other site 381764005443 allosteric effector site; other site 381764005444 fructose-1,6-bisphosphate binding site; other site 381764005445 AAA domain; Region: AAA_32; pfam13654 381764005446 AAA ATPase domain; Region: AAA_16; pfam13191 381764005447 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 381764005448 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 381764005449 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 381764005450 MutL protein; Region: MutL; pfam13941 381764005451 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 381764005452 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 381764005453 putative ligand binding site [chemical binding]; other site 381764005454 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 381764005455 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 381764005456 Walker A/P-loop; other site 381764005457 ATP binding site [chemical binding]; other site 381764005458 Q-loop/lid; other site 381764005459 ABC transporter signature motif; other site 381764005460 Walker B; other site 381764005461 D-loop; other site 381764005462 H-loop/switch region; other site 381764005463 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 381764005464 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 381764005465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 381764005466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 381764005467 TM-ABC transporter signature motif; other site 381764005468 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 381764005469 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 381764005470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 381764005471 nucleotide binding site [chemical binding]; other site 381764005472 LemA family; Region: LemA; cl00742 381764005473 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 381764005474 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 381764005475 dimerization interface [polypeptide binding]; other site 381764005476 putative ATP binding site [chemical binding]; other site 381764005477 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 381764005478 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 381764005479 ATP-grasp domain; Region: ATP-grasp_4; cl17255 381764005480 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 381764005481 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 381764005482 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 381764005483 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 381764005484 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 381764005485 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 381764005486 active site 381764005487 substrate binding site [chemical binding]; other site 381764005488 cosubstrate binding site; other site 381764005489 catalytic site [active] 381764005490 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 381764005491 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 381764005492 active site 381764005493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764005494 active site 381764005495 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 381764005496 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 381764005497 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 381764005498 catalytic site [active] 381764005499 G-X2-G-X-G-K; other site 381764005500 hypothetical protein; Provisional; Region: PRK04323 381764005501 hypothetical protein; Provisional; Region: PRK11820 381764005502 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 381764005503 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 381764005504 transketolase; Reviewed; Region: PRK05899 381764005505 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 381764005506 TPP-binding site [chemical binding]; other site 381764005507 dimer interface [polypeptide binding]; other site 381764005508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 381764005509 PYR/PP interface [polypeptide binding]; other site 381764005510 dimer interface [polypeptide binding]; other site 381764005511 TPP binding site [chemical binding]; other site 381764005512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 381764005513 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 381764005514 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 381764005515 dimer interface [polypeptide binding]; other site 381764005516 active site 381764005517 metal binding site [ion binding]; metal-binding site 381764005518 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 381764005519 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 381764005520 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381764005521 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 381764005522 active site 381764005523 catalytic site [active] 381764005524 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 381764005525 putative ligand binding site [chemical binding]; other site 381764005526 Response regulator receiver domain; Region: Response_reg; pfam00072 381764005527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 381764005528 active site 381764005529 phosphorylation site [posttranslational modification] 381764005530 intermolecular recognition site; other site 381764005531 dimerization interface [polypeptide binding]; other site 381764005532 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 381764005533 TrkA-N domain; Region: TrkA_N; pfam02254 381764005534 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 381764005535 TrkA-N domain; Region: TrkA_N; pfam02254 381764005536 TrkA-C domain; Region: TrkA_C; pfam02080 381764005537 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 381764005538 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 381764005539 AMMECR1; Region: AMMECR1; cl00911 381764005540 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 381764005541 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 381764005542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764005543 S-adenosylmethionine binding site [chemical binding]; other site 381764005544 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 381764005545 C-terminal peptidase (prc); Region: prc; TIGR00225 381764005546 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 381764005547 protein binding site [polypeptide binding]; other site 381764005548 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 381764005549 Catalytic dyad [active] 381764005550 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 381764005551 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 381764005552 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 381764005553 putative ADP-binding pocket [chemical binding]; other site 381764005554 GTPase RsgA; Reviewed; Region: PRK00098 381764005555 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 381764005556 RNA binding site [nucleotide binding]; other site 381764005557 homodimer interface [polypeptide binding]; other site 381764005558 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 381764005559 GTPase/Zn-binding domain interface [polypeptide binding]; other site 381764005560 GTP/Mg2+ binding site [chemical binding]; other site 381764005561 G4 box; other site 381764005562 G5 box; other site 381764005563 G1 box; other site 381764005564 Switch I region; other site 381764005565 G2 box; other site 381764005566 G3 box; other site 381764005567 Switch II region; other site 381764005568 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 381764005569 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469 381764005570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764005571 FeS/SAM binding site; other site 381764005572 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 381764005573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764005574 FeS/SAM binding site; other site 381764005575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 381764005576 Radical SAM superfamily; Region: Radical_SAM; pfam04055 381764005577 FeS/SAM binding site; other site 381764005578 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 381764005579 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 381764005580 oligomer interface [polypeptide binding]; other site 381764005581 active site 381764005582 metal binding site [ion binding]; metal-binding site 381764005583 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 381764005584 Helix-hairpin-helix motif; Region: HHH; pfam00633 381764005585 Helix-hairpin-helix motif; Region: HHH; pfam00633 381764005586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 381764005587 active site 381764005588 phosphorylation site [posttranslational modification] 381764005589 intermolecular recognition site; other site 381764005590 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 381764005591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 381764005592 Zn2+ binding site [ion binding]; other site 381764005593 Mg2+ binding site [ion binding]; other site 381764005594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 381764005595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764005596 ATP binding site [chemical binding]; other site 381764005597 Mg2+ binding site [ion binding]; other site 381764005598 G-X-G motif; other site 381764005599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381764005600 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381764005601 substrate binding pocket [chemical binding]; other site 381764005602 membrane-bound complex binding site; other site 381764005603 hinge residues; other site 381764005604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 381764005605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 381764005606 substrate binding pocket [chemical binding]; other site 381764005607 membrane-bound complex binding site; other site 381764005608 hinge residues; other site 381764005609 Predicted integral membrane protein [Function unknown]; Region: COG5652 381764005610 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 381764005611 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 381764005612 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 381764005613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 381764005614 ATP binding site [chemical binding]; other site 381764005615 Mg2+ binding site [ion binding]; other site 381764005616 G-X-G motif; other site 381764005617 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 381764005618 ATP binding site [chemical binding]; other site 381764005619 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 381764005620 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 381764005621 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381764005622 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 381764005623 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 381764005624 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 381764005625 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 381764005626 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 381764005627 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 381764005628 16S/18S rRNA binding site [nucleotide binding]; other site 381764005629 S13e-L30e interaction site [polypeptide binding]; other site 381764005630 25S rRNA binding site [nucleotide binding]; other site 381764005631 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 381764005632 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 381764005633 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 381764005634 active site 381764005635 putative DNA-binding cleft [nucleotide binding]; other site 381764005636 dimer interface [polypeptide binding]; other site 381764005637 DNA polymerase III PolC; Validated; Region: polC; PRK00448 381764005638 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 381764005639 generic binding surface II; other site 381764005640 generic binding surface I; other site 381764005641 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 381764005642 active site 381764005643 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 381764005644 active site 381764005645 catalytic site [active] 381764005646 substrate binding site [chemical binding]; other site 381764005647 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 381764005648 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 381764005649 Preprotein translocase SecG subunit; Region: SecG; pfam03840 381764005650 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 381764005651 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 381764005652 active site 381764005653 HIGH motif; other site 381764005654 dimer interface [polypeptide binding]; other site 381764005655 KMSKS motif; other site 381764005656 S-layer homology domain; Region: SLH; pfam00395 381764005657 Nitrate and nitrite sensing; Region: NIT; pfam08376 381764005658 enolase; Provisional; Region: eno; PRK00077 381764005659 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 381764005660 dimer interface [polypeptide binding]; other site 381764005661 metal binding site [ion binding]; metal-binding site 381764005662 substrate binding pocket [chemical binding]; other site 381764005663 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 381764005664 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 381764005665 Ca binding site [ion binding]; other site 381764005666 active site 381764005667 catalytic site [active] 381764005668 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 381764005669 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 381764005670 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 381764005671 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 381764005672 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 381764005673 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 381764005674 putative active site [active] 381764005675 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 381764005676 DNA-binding site [nucleotide binding]; DNA binding site 381764005677 RNA-binding motif; other site 381764005678 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 381764005679 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 381764005680 minor groove reading motif; other site 381764005681 helix-hairpin-helix signature motif; other site 381764005682 substrate binding pocket [chemical binding]; other site 381764005683 active site 381764005684 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 381764005685 diiron binding motif [ion binding]; other site 381764005686 putative oxidoreductase; Provisional; Region: PRK13984 381764005687 4Fe-4S binding domain; Region: Fer4; pfam00037 381764005688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 381764005689 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 381764005690 NADH dehydrogenase subunit D; Validated; Region: PRK06075 381764005691 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 381764005692 NADH dehydrogenase subunit B; Validated; Region: PRK06411 381764005693 NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005 381764005694 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 381764005695 NADH dehydrogenase subunit M; Validated; Region: PRK08668 381764005696 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381764005697 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 381764005698 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 381764005699 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 381764005700 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 381764005701 hypothetical protein; Provisional; Region: PRK08378 381764005702 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 381764005703 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 381764005704 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 381764005705 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 381764005706 predicted active site [active] 381764005707 catalytic triad [active] 381764005708 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 381764005709 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 381764005710 active site 381764005711 multimer interface [polypeptide binding]; other site 381764005712 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 381764005713 Flagellar protein FliT; Region: FliT; pfam05400 381764005714 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 381764005715 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 381764005716 catalytic center binding site [active] 381764005717 ATP binding site [chemical binding]; other site 381764005718 oxaloacetate decarboxylase; Provisional; Region: PRK14041 381764005719 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 381764005720 active site 381764005721 catalytic residues [active] 381764005722 metal binding site [ion binding]; metal-binding site 381764005723 homodimer binding site [polypeptide binding]; other site 381764005724 hypothetical protein; Provisional; Region: PRK13670 381764005725 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 381764005726 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 381764005727 DEAD-like helicases superfamily; Region: DEXDc; smart00487 381764005728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 381764005729 ATP binding site [chemical binding]; other site 381764005730 putative Mg++ binding site [ion binding]; other site 381764005731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 381764005732 nucleotide binding region [chemical binding]; other site 381764005733 ATP-binding site [chemical binding]; other site 381764005734 TRCF domain; Region: TRCF; pfam03461 381764005735 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 381764005736 PEGA domain; Region: PEGA; pfam08308 381764005737 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 381764005738 peptide chain release factor 2; Validated; Region: prfB; PRK00578 381764005739 PCRF domain; Region: PCRF; pfam03462 381764005740 RF-1 domain; Region: RF-1; pfam00472 381764005741 septum site-determining protein MinD; Region: minD_bact; TIGR01968 381764005742 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 381764005743 Switch I; other site 381764005744 Switch II; other site 381764005745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764005746 S-adenosylmethionine binding site [chemical binding]; other site 381764005747 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 381764005748 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 381764005749 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 381764005750 P loop; other site 381764005751 GTP binding site [chemical binding]; other site 381764005752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 381764005753 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 381764005754 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 381764005755 Laminin Domain II; Region: Laminin_II; pfam06009 381764005756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 381764005757 Peptidase family M23; Region: Peptidase_M23; pfam01551 381764005758 3D domain; Region: 3D; cl01439 381764005759 Rrf2 family protein; Region: rrf2_super; TIGR00738 381764005760 Transcriptional regulator; Region: Rrf2; pfam02082 381764005761 Transcriptional regulator; Region: Rrf2; cl17282 381764005762 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 381764005763 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 381764005764 Ligand Binding Site [chemical binding]; other site 381764005765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 381764005766 active site 381764005767 Transcriptional regulator [Transcription]; Region: LytR; COG1316 381764005768 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 381764005769 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 381764005770 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 381764005771 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 381764005772 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 381764005773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 381764005774 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 381764005775 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 381764005776 active site 381764005777 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 381764005778 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 381764005779 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 381764005780 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 381764005781 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 381764005782 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 381764005783 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 381764005784 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 381764005785 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 381764005786 cleft; other site 381764005787 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 381764005788 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 381764005789 DNA binding site [nucleotide binding] 381764005790 clamp; other site 381764005791 Rpb1 - Rpb2 interaction site [polypeptide binding]; other site 381764005792 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 381764005793 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 381764005794 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 381764005795 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 381764005796 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 381764005797 RPB1 interaction site [polypeptide binding]; other site 381764005798 RPB10 interaction site [polypeptide binding]; other site 381764005799 RPB11 interaction site [polypeptide binding]; other site 381764005800 RPB3 interaction site [polypeptide binding]; other site 381764005801 RPB12 interaction site [polypeptide binding]; other site 381764005802 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 381764005803 core dimer interface [polypeptide binding]; other site 381764005804 peripheral dimer interface [polypeptide binding]; other site 381764005805 L10 interface [polypeptide binding]; other site 381764005806 L11 interface [polypeptide binding]; other site 381764005807 putative EF-Tu interaction site [polypeptide binding]; other site 381764005808 putative EF-G interaction site [polypeptide binding]; other site 381764005809 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 381764005810 23S rRNA interface [nucleotide binding]; other site 381764005811 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 381764005812 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 381764005813 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 381764005814 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 381764005815 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 381764005816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 381764005817 S-adenosylmethionine binding site [chemical binding]; other site 381764005818 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 381764005819 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 381764005820 putative substrate binding site [chemical binding]; other site 381764005821 nucleotide binding site [chemical binding]; other site 381764005822 nucleotide binding site [chemical binding]; other site 381764005823 homodimer interface [polypeptide binding]; other site 381764005824 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 381764005825 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 381764005826 SxDxEG motif; other site 381764005827 putative active site [active] 381764005828 putative metal binding site [ion binding]; other site