-- dump date 20140619_093244 -- class Genbank::misc_feature -- table misc_feature_note -- id note 771875000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14088 771875000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 771875000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875000004 Walker A motif; other site 771875000005 ATP binding site [chemical binding]; other site 771875000006 Walker B motif; other site 771875000007 arginine finger; other site 771875000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 771875000009 DnaA box-binding interface [nucleotide binding]; other site 771875000010 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 771875000011 ABC transporter G family member; Provisional; Region: PLN03140 771875000012 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 771875000013 ligand binding site [chemical binding]; other site 771875000014 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 771875000015 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 771875000016 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 771875000017 Walker A/P-loop; other site 771875000018 ATP binding site [chemical binding]; other site 771875000019 Q-loop/lid; other site 771875000020 ABC transporter signature motif; other site 771875000021 Walker B; other site 771875000022 D-loop; other site 771875000023 H-loop/switch region; other site 771875000024 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 771875000025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875000026 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 771875000027 TM-ABC transporter signature motif; other site 771875000028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875000029 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 771875000030 TM-ABC transporter signature motif; other site 771875000031 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 771875000032 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 771875000033 IHF dimer interface [polypeptide binding]; other site 771875000034 IHF - DNA interface [nucleotide binding]; other site 771875000035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 771875000036 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 771875000037 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 771875000038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875000039 Zn2+ binding site [ion binding]; other site 771875000040 Mg2+ binding site [ion binding]; other site 771875000041 FecR protein; Region: FecR; pfam04773 771875000042 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 771875000043 HD domain; Region: HD_5; pfam13487 771875000044 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875000045 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875000046 Integrase core domain; Region: rve; pfam00665 771875000047 CHASE2 domain; Region: CHASE2; pfam05226 771875000048 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 771875000049 cyclase homology domain; Region: CHD; cd07302 771875000050 nucleotidyl binding site; other site 771875000051 metal binding site [ion binding]; metal-binding site 771875000052 dimer interface [polypeptide binding]; other site 771875000053 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875000054 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875000055 Integrase core domain; Region: rve; pfam00665 771875000056 Uncharacterized conserved protein [Function unknown]; Region: COG0432 771875000057 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 771875000058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875000059 putative active site [active] 771875000060 heme pocket [chemical binding]; other site 771875000061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875000062 putative active site [active] 771875000063 heme pocket [chemical binding]; other site 771875000064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875000065 Walker A motif; other site 771875000066 ATP binding site [chemical binding]; other site 771875000067 Walker B motif; other site 771875000068 arginine finger; other site 771875000069 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 771875000070 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 771875000071 HTH-like domain; Region: HTH_21; pfam13276 771875000072 Integrase core domain; Region: rve; pfam00665 771875000073 FOG: WD40-like repeat [Function unknown]; Region: COG1520 771875000074 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 771875000075 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875000076 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875000077 Integrase core domain; Region: rve; pfam00665 771875000078 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 771875000079 oligomerisation interface [polypeptide binding]; other site 771875000080 mobile loop; other site 771875000081 roof hairpin; other site 771875000082 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 771875000083 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 771875000084 ring oligomerisation interface [polypeptide binding]; other site 771875000085 ATP/Mg binding site [chemical binding]; other site 771875000086 stacking interactions; other site 771875000087 hinge regions; other site 771875000088 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 771875000089 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 771875000090 NADP+ binding site [chemical binding]; other site 771875000091 folate binding site [chemical binding]; other site 771875000092 RibD C-terminal domain; Region: RibD_C; cl17279 771875000093 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 771875000094 elongation factor G; Reviewed; Region: PRK12740 771875000095 G1 box; other site 771875000096 putative GEF interaction site [polypeptide binding]; other site 771875000097 GTP/Mg2+ binding site [chemical binding]; other site 771875000098 Switch I region; other site 771875000099 G2 box; other site 771875000100 G3 box; other site 771875000101 Switch II region; other site 771875000102 G4 box; other site 771875000103 G5 box; other site 771875000104 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 771875000105 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 771875000106 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 771875000107 MgtE intracellular N domain; Region: MgtE_N; cl15244 771875000108 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 771875000109 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 771875000110 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 771875000111 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 771875000112 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 771875000113 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 771875000114 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 771875000115 Flagellar protein (FlbD); Region: FlbD; pfam06289 771875000116 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 771875000117 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 771875000118 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 771875000119 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 771875000120 ligand binding site [chemical binding]; other site 771875000121 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 771875000122 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 771875000123 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 771875000124 flagellar motor switch protein; Validated; Region: PRK08119 771875000125 CheC-like family; Region: CheC; pfam04509 771875000126 CheC-like family; Region: CheC; pfam04509 771875000127 flagellar motor switch protein FliN; Region: fliN; TIGR02480 771875000128 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 771875000129 beta-galactosidase; Region: BGL; TIGR03356 771875000130 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 771875000131 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 771875000132 imidazolonepropionase; Validated; Region: PRK09356 771875000133 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 771875000134 active site 771875000135 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 771875000136 active site 771875000137 dimerization interface [polypeptide binding]; other site 771875000138 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 771875000139 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 771875000140 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 771875000141 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 771875000142 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 771875000143 MgtE intracellular N domain; Region: MgtE_N; smart00924 771875000144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 771875000145 Divalent cation transporter; Region: MgtE; pfam01769 771875000146 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 771875000147 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 771875000148 HIGH motif; other site 771875000149 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 771875000150 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 771875000151 active site 771875000152 KMSKS motif; other site 771875000153 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 771875000154 tRNA binding surface [nucleotide binding]; other site 771875000155 SurA N-terminal domain; Region: SurA_N_3; cl07813 771875000156 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 771875000157 Ion channel; Region: Ion_trans_2; pfam07885 771875000158 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 771875000159 TrkA-N domain; Region: TrkA_N; pfam02254 771875000160 TrkA-C domain; Region: TrkA_C; pfam02080 771875000161 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 771875000162 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 771875000163 seryl-tRNA synthetase; Provisional; Region: PRK05431 771875000164 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 771875000165 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 771875000166 dimer interface [polypeptide binding]; other site 771875000167 active site 771875000168 motif 1; other site 771875000169 motif 2; other site 771875000170 motif 3; other site 771875000171 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 771875000172 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 771875000173 TPP-binding site; other site 771875000174 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 771875000175 PYR/PP interface [polypeptide binding]; other site 771875000176 dimer interface [polypeptide binding]; other site 771875000177 TPP binding site [chemical binding]; other site 771875000178 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 771875000179 Asp23 family; Region: Asp23; pfam03780 771875000180 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 771875000181 DAK2 domain; Region: Dak2; pfam02734 771875000182 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 771875000183 monoglyceride lipase; Provisional; Region: PHA02857 771875000184 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 771875000185 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 771875000186 flagellar assembly protein FliW; Provisional; Region: PRK13285 771875000187 carbon storage regulator; Provisional; Region: PRK01712 771875000188 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 771875000189 hypothetical protein; Reviewed; Region: PRK12497 771875000190 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 771875000191 SmpB-tmRNA interface; other site 771875000192 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 771875000193 intersubunit interface [polypeptide binding]; other site 771875000194 active site 771875000195 catalytic residue [active] 771875000196 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 771875000197 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 771875000198 ligand binding site; other site 771875000199 oligomer interface; other site 771875000200 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 771875000201 dimer interface [polypeptide binding]; other site 771875000202 N-terminal domain interface [polypeptide binding]; other site 771875000203 sulfate 1 binding site; other site 771875000204 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 771875000205 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 771875000206 ligand binding site; other site 771875000207 oligomer interface; other site 771875000208 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 771875000209 dimer interface [polypeptide binding]; other site 771875000210 N-terminal domain interface [polypeptide binding]; other site 771875000211 sulfate 1 binding site; other site 771875000212 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 771875000213 homotrimer interaction site [polypeptide binding]; other site 771875000214 zinc binding site [ion binding]; other site 771875000215 CDP-binding sites; other site 771875000216 ribosome recycling factor; Reviewed; Region: frr; PRK00083 771875000217 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 771875000218 hinge region; other site 771875000219 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 771875000220 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 771875000221 catalytic residue [active] 771875000222 putative FPP diphosphate binding site; other site 771875000223 putative FPP binding hydrophobic cleft; other site 771875000224 dimer interface [polypeptide binding]; other site 771875000225 putative IPP diphosphate binding site; other site 771875000226 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 771875000227 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 771875000228 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 771875000229 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 771875000230 motif 1; other site 771875000231 active site 771875000232 motif 2; other site 771875000233 motif 3; other site 771875000234 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 771875000235 DHHA1 domain; Region: DHHA1; pfam02272 771875000236 rod shape-determining protein MreB; Provisional; Region: PRK13930 771875000237 MreB and similar proteins; Region: MreB_like; cd10225 771875000238 nucleotide binding site [chemical binding]; other site 771875000239 Mg binding site [ion binding]; other site 771875000240 putative protofilament interaction site [polypeptide binding]; other site 771875000241 RodZ interaction site [polypeptide binding]; other site 771875000242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875000243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875000244 metal binding site [ion binding]; metal-binding site 771875000245 active site 771875000246 I-site; other site 771875000247 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 771875000248 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 771875000249 hinge; other site 771875000250 active site 771875000251 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 771875000252 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 771875000253 NAD(P) binding site [chemical binding]; other site 771875000254 homodimer interface [polypeptide binding]; other site 771875000255 substrate binding site [chemical binding]; other site 771875000256 active site 771875000257 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 771875000258 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 771875000259 dimerization interface [polypeptide binding]; other site 771875000260 domain crossover interface; other site 771875000261 redox-dependent activation switch; other site 771875000262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 771875000263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875000264 active site 771875000265 phosphorylation site [posttranslational modification] 771875000266 intermolecular recognition site; other site 771875000267 dimerization interface [polypeptide binding]; other site 771875000268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 771875000269 DNA binding site [nucleotide binding] 771875000270 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 771875000271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 771875000272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 771875000273 dimer interface [polypeptide binding]; other site 771875000274 phosphorylation site [posttranslational modification] 771875000275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875000276 ATP binding site [chemical binding]; other site 771875000277 Mg2+ binding site [ion binding]; other site 771875000278 G-X-G motif; other site 771875000279 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 771875000280 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 771875000281 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 771875000282 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 771875000283 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 771875000284 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 771875000285 RNA/DNA hybrid binding site [nucleotide binding]; other site 771875000286 active site 771875000287 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 771875000288 Domain of unknown function DUF20; Region: UPF0118; pfam01594 771875000289 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 771875000290 active site 771875000291 dimer interfaces [polypeptide binding]; other site 771875000292 catalytic residues [active] 771875000293 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 771875000294 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 771875000295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 771875000296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875000297 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 771875000298 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 771875000299 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 771875000300 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 771875000301 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 771875000302 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 771875000303 Protein of unknown function (DUF464); Region: DUF464; pfam04327 771875000304 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 771875000305 Predicted membrane protein [Function unknown]; Region: COG3601 771875000306 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 771875000307 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 771875000308 23S rRNA interface [nucleotide binding]; other site 771875000309 L3 interface [polypeptide binding]; other site 771875000310 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 771875000311 DNA primase, catalytic core; Region: dnaG; TIGR01391 771875000312 CHC2 zinc finger; Region: zf-CHC2; pfam01807 771875000313 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 771875000314 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 771875000315 active site 771875000316 metal binding site [ion binding]; metal-binding site 771875000317 interdomain interaction site; other site 771875000318 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 771875000319 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 771875000320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 771875000321 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 771875000322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 771875000323 DNA binding residues [nucleotide binding] 771875000324 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 771875000325 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 771875000326 FtsX-like permease family; Region: FtsX; pfam02687 771875000327 FtsX-like permease family; Region: FtsX; pfam02687 771875000328 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 771875000329 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 771875000330 SLBB domain; Region: SLBB; pfam10531 771875000331 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 771875000332 Chain length determinant protein; Region: Wzz; pfam02706 771875000333 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 771875000334 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 771875000335 Bacterial sugar transferase; Region: Bac_transf; pfam02397 771875000336 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 771875000337 putative glycosyl transferase; Provisional; Region: PRK10307 771875000338 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 771875000339 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 771875000340 NAD(P) binding site [chemical binding]; other site 771875000341 homodimer interface [polypeptide binding]; other site 771875000342 substrate binding site [chemical binding]; other site 771875000343 active site 771875000344 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 771875000345 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 771875000346 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 771875000347 putative NAD(P) binding site [chemical binding]; other site 771875000348 active site 771875000349 putative substrate binding site [chemical binding]; other site 771875000350 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 771875000351 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 771875000352 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 771875000353 active site 771875000354 homodimer interface [polypeptide binding]; other site 771875000355 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 771875000356 putative glycosyl transferase; Provisional; Region: PRK10125 771875000357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875000358 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 771875000359 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 771875000360 putative active site [active] 771875000361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 771875000362 active site 771875000363 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 771875000364 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 771875000365 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 771875000366 substrate binding site; other site 771875000367 tetramer interface; other site 771875000368 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 771875000369 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 771875000370 inhibitor-cofactor binding pocket; inhibition site 771875000371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875000372 catalytic residue [active] 771875000373 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 771875000374 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 771875000375 trimer interface [polypeptide binding]; other site 771875000376 active site 771875000377 substrate binding site [chemical binding]; other site 771875000378 CoA binding site [chemical binding]; other site 771875000379 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 771875000380 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 771875000381 NAD binding site [chemical binding]; other site 771875000382 substrate binding site [chemical binding]; other site 771875000383 homodimer interface [polypeptide binding]; other site 771875000384 active site 771875000385 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 771875000386 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 771875000387 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 771875000388 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 771875000389 putative active site [active] 771875000390 Archaeal ATPase; Region: Arch_ATPase; pfam01637 771875000391 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 771875000392 active site 771875000393 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 771875000394 homodimer interface [polypeptide binding]; other site 771875000395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875000396 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 771875000397 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875000398 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875000399 Integrase core domain; Region: rve; pfam00665 771875000400 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 771875000401 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 771875000402 active site 771875000403 homodimer interface [polypeptide binding]; other site 771875000404 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 771875000405 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 771875000406 putative ligand binding site [chemical binding]; other site 771875000407 putative NAD binding site [chemical binding]; other site 771875000408 catalytic site [active] 771875000409 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 771875000410 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 771875000411 N- and C-terminal domain interface [polypeptide binding]; other site 771875000412 active site 771875000413 catalytic site [active] 771875000414 metal binding site [ion binding]; metal-binding site 771875000415 carbohydrate binding site [chemical binding]; other site 771875000416 ATP binding site [chemical binding]; other site 771875000417 Transcriptional regulators [Transcription]; Region: FadR; COG2186 771875000418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 771875000419 DNA-binding site [nucleotide binding]; DNA binding site 771875000420 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 771875000421 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 771875000422 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 771875000423 active site 771875000424 intersubunit interface [polypeptide binding]; other site 771875000425 catalytic residue [active] 771875000426 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 771875000427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 771875000428 nucleotide binding site [chemical binding]; other site 771875000429 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 771875000430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 771875000431 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 771875000432 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 771875000433 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 771875000434 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 771875000435 Transcriptional regulator [Transcription]; Region: LytR; COG1316 771875000436 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 771875000437 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 771875000438 Ligand binding site; other site 771875000439 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 771875000440 active site 771875000441 NTP binding site [chemical binding]; other site 771875000442 metal binding triad [ion binding]; metal-binding site 771875000443 antibiotic binding site [chemical binding]; other site 771875000444 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 771875000445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875000446 motif II; other site 771875000447 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 771875000448 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 771875000449 Substrate binding site; other site 771875000450 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 771875000451 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 771875000452 putative trimer interface [polypeptide binding]; other site 771875000453 putative CoA binding site [chemical binding]; other site 771875000454 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 771875000455 putative trimer interface [polypeptide binding]; other site 771875000456 putative active site [active] 771875000457 putative substrate binding site [chemical binding]; other site 771875000458 putative CoA binding site [chemical binding]; other site 771875000459 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 771875000460 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 771875000461 substrate binding site [chemical binding]; other site 771875000462 dimer interface [polypeptide binding]; other site 771875000463 ATP binding site [chemical binding]; other site 771875000464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875000465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875000466 DNA binding site [nucleotide binding] 771875000467 domain linker motif; other site 771875000468 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875000469 dimerization interface [polypeptide binding]; other site 771875000470 ligand binding site [chemical binding]; other site 771875000471 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 771875000472 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 771875000473 ligand binding site [chemical binding]; other site 771875000474 dimerization interface [polypeptide binding]; other site 771875000475 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 771875000476 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 771875000477 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875000478 TM-ABC transporter signature motif; other site 771875000479 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 771875000480 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 771875000481 Walker A/P-loop; other site 771875000482 ATP binding site [chemical binding]; other site 771875000483 Q-loop/lid; other site 771875000484 ABC transporter signature motif; other site 771875000485 Walker B; other site 771875000486 D-loop; other site 771875000487 H-loop/switch region; other site 771875000488 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 771875000489 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 771875000490 Radical SAM superfamily; Region: Radical_SAM; pfam04055 771875000491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875000492 FeS/SAM binding site; other site 771875000493 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 771875000494 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 771875000495 Protein of unknown function DUF45; Region: DUF45; pfam01863 771875000496 GTPase CgtA; Reviewed; Region: obgE; PRK12297 771875000497 GTP1/OBG; Region: GTP1_OBG; pfam01018 771875000498 Obg GTPase; Region: Obg; cd01898 771875000499 G1 box; other site 771875000500 GTP/Mg2+ binding site [chemical binding]; other site 771875000501 Switch I region; other site 771875000502 G2 box; other site 771875000503 G3 box; other site 771875000504 Switch II region; other site 771875000505 G4 box; other site 771875000506 G5 box; other site 771875000507 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 771875000508 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 771875000509 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 771875000510 active site 771875000511 (T/H)XGH motif; other site 771875000512 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 771875000513 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 771875000514 FMN binding site [chemical binding]; other site 771875000515 active site 771875000516 catalytic residues [active] 771875000517 substrate binding site [chemical binding]; other site 771875000518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 771875000519 catalytic core [active] 771875000520 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 771875000521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875000522 Walker A/P-loop; other site 771875000523 ATP binding site [chemical binding]; other site 771875000524 Q-loop/lid; other site 771875000525 ABC transporter signature motif; other site 771875000526 Walker B; other site 771875000527 D-loop; other site 771875000528 H-loop/switch region; other site 771875000529 TOBE domain; Region: TOBE_2; pfam08402 771875000530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000531 dimer interface [polypeptide binding]; other site 771875000532 conserved gate region; other site 771875000533 putative PBP binding loops; other site 771875000534 ABC-ATPase subunit interface; other site 771875000535 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 771875000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000537 putative PBP binding loops; other site 771875000538 dimer interface [polypeptide binding]; other site 771875000539 ABC-ATPase subunit interface; other site 771875000540 purine nucleoside phosphorylase; Provisional; Region: PRK08202 771875000541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 771875000542 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 771875000543 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 771875000544 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 771875000545 trmE is a tRNA modification GTPase; Region: trmE; cd04164 771875000546 G1 box; other site 771875000547 GTP/Mg2+ binding site [chemical binding]; other site 771875000548 Switch I region; other site 771875000549 G2 box; other site 771875000550 Switch II region; other site 771875000551 G3 box; other site 771875000552 G4 box; other site 771875000553 G5 box; other site 771875000554 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 771875000555 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 771875000556 FHIPEP family; Region: FHIPEP; pfam00771 771875000557 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 771875000558 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 771875000559 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 771875000560 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 771875000561 PilZ domain; Region: PilZ; pfam07238 771875000562 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 771875000563 Flagellar protein YcgR; Region: YcgR_2; pfam12945 771875000564 PilZ domain; Region: PilZ; pfam07238 771875000565 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 771875000566 CheC-like family; Region: CheC; pfam04509 771875000567 CheC-like family; Region: CheC; pfam04509 771875000568 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13495 771875000569 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 771875000570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 771875000571 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 771875000572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 771875000573 DNA binding residues [nucleotide binding] 771875000574 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 771875000575 SLBB domain; Region: SLBB; pfam10531 771875000576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 771875000577 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 771875000578 FMN-binding domain; Region: FMN_bind; cl01081 771875000579 electron transport complex RsxE subunit; Provisional; Region: PRK12405 771875000580 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 771875000581 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 771875000582 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 771875000583 RNase E interface [polypeptide binding]; other site 771875000584 trimer interface [polypeptide binding]; other site 771875000585 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 771875000586 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 771875000587 RNase E interface [polypeptide binding]; other site 771875000588 trimer interface [polypeptide binding]; other site 771875000589 active site 771875000590 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 771875000591 nucleic acid binding region [nucleotide binding]; other site 771875000592 G-X-X-G motif; other site 771875000593 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 771875000594 RNA binding site [nucleotide binding]; other site 771875000595 domain interface; other site 771875000596 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 771875000597 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 771875000598 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 771875000599 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 771875000600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875000601 Walker A motif; other site 771875000602 ATP binding site [chemical binding]; other site 771875000603 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 771875000604 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 771875000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000606 dimer interface [polypeptide binding]; other site 771875000607 conserved gate region; other site 771875000608 putative PBP binding loops; other site 771875000609 ABC-ATPase subunit interface; other site 771875000610 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875000611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000612 dimer interface [polypeptide binding]; other site 771875000613 conserved gate region; other site 771875000614 putative PBP binding loops; other site 771875000615 ABC-ATPase subunit interface; other site 771875000616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875000617 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 771875000618 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 771875000619 active site 771875000620 Riboflavin kinase; Region: Flavokinase; pfam01687 771875000621 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 771875000622 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 771875000623 minor groove reading motif; other site 771875000624 helix-hairpin-helix signature motif; other site 771875000625 substrate binding pocket [chemical binding]; other site 771875000626 active site 771875000627 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 771875000628 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 771875000629 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 771875000630 FlaG protein; Region: FlaG; pfam03646 771875000631 Ribosome-binding factor A; Region: RBFA; pfam02033 771875000632 HDOD domain; Region: HDOD; pfam08668 771875000633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875000634 Zn2+ binding site [ion binding]; other site 771875000635 Mg2+ binding site [ion binding]; other site 771875000636 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 771875000637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 771875000638 dimer interface [polypeptide binding]; other site 771875000639 phosphorylation site [posttranslational modification] 771875000640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875000641 ATP binding site [chemical binding]; other site 771875000642 Mg2+ binding site [ion binding]; other site 771875000643 G-X-G motif; other site 771875000644 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 771875000645 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 771875000646 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 771875000647 active site 771875000648 HIGH motif; other site 771875000649 KMSK motif region; other site 771875000650 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 771875000651 tRNA binding surface [nucleotide binding]; other site 771875000652 anticodon binding site; other site 771875000653 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 771875000654 G1 box; other site 771875000655 GTP/Mg2+ binding site [chemical binding]; other site 771875000656 Switch I region; other site 771875000657 G2 box; other site 771875000658 G3 box; other site 771875000659 Switch II region; other site 771875000660 G4 box; other site 771875000661 G5 box; other site 771875000662 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 771875000663 Found in ATP-dependent protease La (LON); Region: LON; smart00464 771875000664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875000665 Walker A motif; other site 771875000666 ATP binding site [chemical binding]; other site 771875000667 Walker B motif; other site 771875000668 arginine finger; other site 771875000669 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 771875000670 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 771875000671 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 771875000672 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 771875000673 N- and C-terminal domain interface [polypeptide binding]; other site 771875000674 active site 771875000675 MgATP binding site [chemical binding]; other site 771875000676 catalytic site [active] 771875000677 metal binding site [ion binding]; metal-binding site 771875000678 glycerol binding site [chemical binding]; other site 771875000679 homotetramer interface [polypeptide binding]; other site 771875000680 homodimer interface [polypeptide binding]; other site 771875000681 protein IIAGlc interface [polypeptide binding]; other site 771875000682 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 771875000683 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 771875000684 DNA polymerase III subunit delta'; Validated; Region: PRK08485 771875000685 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 771875000686 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 771875000687 substrate binding pocket [chemical binding]; other site 771875000688 chain length determination region; other site 771875000689 substrate-Mg2+ binding site; other site 771875000690 catalytic residues [active] 771875000691 aspartate-rich region 1; other site 771875000692 active site lid residues [active] 771875000693 aspartate-rich region 2; other site 771875000694 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 771875000695 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 771875000696 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 771875000697 active site 771875000698 catalytic site [active] 771875000699 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 771875000700 homotrimer interaction site [polypeptide binding]; other site 771875000701 putative active site [active] 771875000702 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 771875000703 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 771875000704 Walker A/P-loop; other site 771875000705 ATP binding site [chemical binding]; other site 771875000706 Q-loop/lid; other site 771875000707 ABC transporter signature motif; other site 771875000708 Walker B; other site 771875000709 D-loop; other site 771875000710 H-loop/switch region; other site 771875000711 Uncharacterized conserved protein [Function unknown]; Region: COG1284 771875000712 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 771875000713 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 771875000714 Cache domain; Region: Cache_1; pfam02743 771875000715 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 771875000716 dimerization interface [polypeptide binding]; other site 771875000717 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 771875000718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875000719 dimer interface [polypeptide binding]; other site 771875000720 putative CheW interface [polypeptide binding]; other site 771875000721 putative acyltransferase; Provisional; Region: PRK05790 771875000722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 771875000723 dimer interface [polypeptide binding]; other site 771875000724 active site 771875000725 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875000726 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875000727 Integrase core domain; Region: rve; pfam00665 771875000728 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 771875000729 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 771875000730 NAD(P) binding site [chemical binding]; other site 771875000731 homotetramer interface [polypeptide binding]; other site 771875000732 homodimer interface [polypeptide binding]; other site 771875000733 active site 771875000734 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 771875000735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 771875000736 substrate binding pocket [chemical binding]; other site 771875000737 membrane-bound complex binding site; other site 771875000738 hinge residues; other site 771875000739 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 771875000740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 771875000741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875000742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875000743 putative substrate translocation pore; other site 771875000744 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 771875000745 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 771875000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875000747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875000748 putative substrate translocation pore; other site 771875000749 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 771875000750 Clp amino terminal domain; Region: Clp_N; pfam02861 771875000751 Clp amino terminal domain; Region: Clp_N; pfam02861 771875000752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875000753 Walker A motif; other site 771875000754 ATP binding site [chemical binding]; other site 771875000755 Walker B motif; other site 771875000756 arginine finger; other site 771875000757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875000758 Walker A motif; other site 771875000759 ATP binding site [chemical binding]; other site 771875000760 Walker B motif; other site 771875000761 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 771875000762 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 771875000763 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 771875000764 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 771875000765 dimer interface [polypeptide binding]; other site 771875000766 ssDNA binding site [nucleotide binding]; other site 771875000767 tetramer (dimer of dimers) interface [polypeptide binding]; other site 771875000768 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 771875000769 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 771875000770 GTPase Era; Reviewed; Region: era; PRK00089 771875000771 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 771875000772 G1 box; other site 771875000773 GTP/Mg2+ binding site [chemical binding]; other site 771875000774 Switch I region; other site 771875000775 G2 box; other site 771875000776 Switch II region; other site 771875000777 G3 box; other site 771875000778 G4 box; other site 771875000779 G5 box; other site 771875000780 KH domain; Region: KH_2; pfam07650 771875000781 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 771875000782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 771875000783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 771875000784 Walker A/P-loop; other site 771875000785 ATP binding site [chemical binding]; other site 771875000786 Q-loop/lid; other site 771875000787 ABC transporter signature motif; other site 771875000788 Walker B; other site 771875000789 D-loop; other site 771875000790 H-loop/switch region; other site 771875000791 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 771875000792 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 771875000793 active site 771875000794 (T/H)XGH motif; other site 771875000795 replicative DNA helicase; Region: DnaB; TIGR00665 771875000796 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 771875000797 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 771875000798 Walker A motif; other site 771875000799 ATP binding site [chemical binding]; other site 771875000800 Walker B motif; other site 771875000801 DNA binding loops [nucleotide binding] 771875000802 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 771875000803 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 771875000804 putative active site [active] 771875000805 catalytic triad [active] 771875000806 putative dimer interface [polypeptide binding]; other site 771875000807 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 771875000808 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 771875000809 inhibitor-cofactor binding pocket; inhibition site 771875000810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875000811 catalytic residue [active] 771875000812 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 771875000813 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 771875000814 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 771875000815 23S rRNA binding site [nucleotide binding]; other site 771875000816 L21 binding site [polypeptide binding]; other site 771875000817 L13 binding site [polypeptide binding]; other site 771875000818 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 771875000819 translation initiation factor IF-3; Region: infC; TIGR00168 771875000820 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 771875000821 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 771875000822 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 771875000823 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 771875000824 Mg++ binding site [ion binding]; other site 771875000825 putative catalytic motif [active] 771875000826 substrate binding site [chemical binding]; other site 771875000827 O-Antigen ligase; Region: Wzy_C; pfam04932 771875000828 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 771875000829 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 771875000830 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 771875000831 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 771875000832 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 771875000833 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 771875000834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 771875000835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875000836 homodimer interface [polypeptide binding]; other site 771875000837 catalytic residue [active] 771875000838 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 771875000839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875000840 Coenzyme A binding pocket [chemical binding]; other site 771875000841 GMP synthase; Reviewed; Region: guaA; PRK00074 771875000842 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 771875000843 AMP/PPi binding site [chemical binding]; other site 771875000844 candidate oxyanion hole; other site 771875000845 catalytic triad [active] 771875000846 potential glutamine specificity residues [chemical binding]; other site 771875000847 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 771875000848 ATP Binding subdomain [chemical binding]; other site 771875000849 Ligand Binding sites [chemical binding]; other site 771875000850 Dimerization subdomain; other site 771875000851 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 771875000852 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 771875000853 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 771875000854 putative active site [active] 771875000855 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 771875000856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000857 dimer interface [polypeptide binding]; other site 771875000858 conserved gate region; other site 771875000859 putative PBP binding loops; other site 771875000860 ABC-ATPase subunit interface; other site 771875000861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000862 dimer interface [polypeptide binding]; other site 771875000863 conserved gate region; other site 771875000864 putative PBP binding loops; other site 771875000865 ABC-ATPase subunit interface; other site 771875000866 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 771875000867 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 771875000868 active site 771875000869 substrate binding site [chemical binding]; other site 771875000870 metal binding site [ion binding]; metal-binding site 771875000871 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 771875000872 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 771875000873 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 771875000874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875000875 active site 771875000876 metal binding site [ion binding]; metal-binding site 771875000877 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 771875000878 Glucose inhibited division protein A; Region: GIDA; pfam01134 771875000879 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; Region: MATE_MJ0709_like; cd13147 771875000880 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 771875000881 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13942 771875000882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875000883 S-adenosylmethionine binding site [chemical binding]; other site 771875000884 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 771875000885 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 771875000886 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 771875000887 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875000888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875000889 metal binding site [ion binding]; metal-binding site 771875000890 active site 771875000891 I-site; other site 771875000892 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 771875000893 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 771875000894 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 771875000895 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875000896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875000897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875000898 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875000899 Phosphoglycerate kinase; Region: PGK; pfam00162 771875000900 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 771875000901 substrate binding site [chemical binding]; other site 771875000902 hinge regions; other site 771875000903 ADP binding site [chemical binding]; other site 771875000904 catalytic site [active] 771875000905 triosephosphate isomerase; Provisional; Region: PRK14565 771875000906 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 771875000907 dimer interface [polypeptide binding]; other site 771875000908 substrate binding site [chemical binding]; other site 771875000909 catalytic triad [active] 771875000910 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 771875000911 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 771875000912 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 771875000913 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 771875000914 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 771875000915 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 771875000916 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 771875000917 active site 771875000918 homodimer interface [polypeptide binding]; other site 771875000919 catalytic site [active] 771875000920 Methyltransferase domain; Region: Methyltransf_23; pfam13489 771875000921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875000922 S-adenosylmethionine binding site [chemical binding]; other site 771875000923 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 771875000924 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 771875000925 tetramer interface [polypeptide binding]; other site 771875000926 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 771875000927 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 771875000928 G1 box; other site 771875000929 GTP/Mg2+ binding site [chemical binding]; other site 771875000930 Switch I region; other site 771875000931 G2 box; other site 771875000932 Switch II region; other site 771875000933 G3 box; other site 771875000934 G4 box; other site 771875000935 G5 box; other site 771875000936 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 771875000937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 771875000938 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 771875000939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875000940 Walker A/P-loop; other site 771875000941 ATP binding site [chemical binding]; other site 771875000942 Q-loop/lid; other site 771875000943 ABC transporter signature motif; other site 771875000944 Walker B; other site 771875000945 D-loop; other site 771875000946 H-loop/switch region; other site 771875000947 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 771875000948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875000949 dimer interface [polypeptide binding]; other site 771875000950 conserved gate region; other site 771875000951 ABC-ATPase subunit interface; other site 771875000952 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 771875000953 biotin synthase; Provisional; Region: PRK07094 771875000954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875000955 FeS/SAM binding site; other site 771875000956 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 771875000957 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 771875000958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875000959 FeS/SAM binding site; other site 771875000960 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 771875000961 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 771875000962 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 771875000963 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 771875000964 catalytic loop [active] 771875000965 iron binding site [ion binding]; other site 771875000966 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 771875000967 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 771875000968 4Fe-4S binding domain; Region: Fer4; pfam00037 771875000969 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 771875000970 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 771875000971 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 771875000972 catalytic loop [active] 771875000973 iron binding site [ion binding]; other site 771875000974 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 771875000975 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 771875000976 4Fe-4S binding domain; Region: Fer4; pfam00037 771875000977 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 771875000978 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 771875000979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875000980 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 771875000981 active site 771875000982 motif I; other site 771875000983 motif II; other site 771875000984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875000985 RNA polymerase factor sigma-70; Validated; Region: PRK08295 771875000986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 771875000987 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 771875000988 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 771875000989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875000990 active site 771875000991 motif I; other site 771875000992 motif II; other site 771875000993 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 771875000994 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 771875000995 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 771875000996 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 771875000997 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 771875000998 catalytic triad [active] 771875000999 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 771875001000 putative FMN binding site [chemical binding]; other site 771875001001 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 771875001002 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 771875001003 TPP-binding site [chemical binding]; other site 771875001004 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 771875001005 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 771875001006 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 771875001007 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 771875001008 dimer interface [polypeptide binding]; other site 771875001009 PYR/PP interface [polypeptide binding]; other site 771875001010 TPP binding site [chemical binding]; other site 771875001011 substrate binding site [chemical binding]; other site 771875001012 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 771875001013 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 771875001014 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 771875001015 dimer interface [polypeptide binding]; other site 771875001016 PYR/PP interface [polypeptide binding]; other site 771875001017 TPP binding site [chemical binding]; other site 771875001018 substrate binding site [chemical binding]; other site 771875001019 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 771875001020 TPP-binding site; other site 771875001021 4Fe-4S binding domain; Region: Fer4; pfam00037 771875001022 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 771875001023 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 771875001024 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 771875001025 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 771875001026 CoA-ligase; Region: Ligase_CoA; pfam00549 771875001027 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 771875001028 CoA binding domain; Region: CoA_binding_2; pfam13380 771875001029 CoA-ligase; Region: Ligase_CoA; pfam00549 771875001030 Uncharacterized conserved protein [Function unknown]; Region: COG1284 771875001031 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 771875001032 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 771875001033 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 771875001034 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 771875001035 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 771875001036 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 771875001037 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 771875001038 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 771875001039 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 771875001040 dihydrodipicolinate synthase; Region: dapA; TIGR00674 771875001041 dimer interface [polypeptide binding]; other site 771875001042 active site 771875001043 catalytic residue [active] 771875001044 dihydrodipicolinate reductase; Provisional; Region: PRK00048 771875001045 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 771875001046 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 771875001047 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 771875001048 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 771875001049 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 771875001050 active site 771875001051 trimer interface [polypeptide binding]; other site 771875001052 substrate binding site [chemical binding]; other site 771875001053 CoA binding site [chemical binding]; other site 771875001054 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 771875001055 putative CoA binding site [chemical binding]; other site 771875001056 putative trimer interface [polypeptide binding]; other site 771875001057 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 771875001058 aspartate kinase; Reviewed; Region: PRK06635 771875001059 putative nucleotide binding site [chemical binding]; other site 771875001060 putative catalytic residues [active] 771875001061 putative Mg ion binding site [ion binding]; other site 771875001062 putative aspartate binding site [chemical binding]; other site 771875001063 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 771875001064 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 771875001065 putative allosteric regulatory residue; other site 771875001066 acetylornithine aminotransferase; Provisional; Region: PRK02627 771875001067 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 771875001068 inhibitor-cofactor binding pocket; inhibition site 771875001069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875001070 catalytic residue [active] 771875001071 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 771875001072 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 771875001073 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 771875001074 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 771875001075 metal binding site [ion binding]; metal-binding site 771875001076 dimer interface [polypeptide binding]; other site 771875001077 Starch binding domain; Region: CBM_2; smart01065 771875001078 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 771875001079 Putative esterase; Region: Esterase; pfam00756 771875001080 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 771875001081 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 771875001082 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 771875001083 dimer interface [polypeptide binding]; other site 771875001084 active site 771875001085 glycine-pyridoxal phosphate binding site [chemical binding]; other site 771875001086 folate binding site [chemical binding]; other site 771875001087 Uncharacterized conserved protein [Function unknown]; Region: COG4198 771875001088 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 771875001089 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 771875001090 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 771875001091 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 771875001092 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 771875001093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 771875001094 nucleotide binding site [chemical binding]; other site 771875001095 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 771875001096 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 771875001097 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 771875001098 Walker A/P-loop; other site 771875001099 ATP binding site [chemical binding]; other site 771875001100 Q-loop/lid; other site 771875001101 ABC transporter signature motif; other site 771875001102 Walker B; other site 771875001103 D-loop; other site 771875001104 H-loop/switch region; other site 771875001105 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 771875001106 Response regulator receiver domain; Region: Response_reg; pfam00072 771875001107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875001108 active site 771875001109 phosphorylation site [posttranslational modification] 771875001110 intermolecular recognition site; other site 771875001111 dimerization interface [polypeptide binding]; other site 771875001112 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 771875001113 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 771875001114 elongation factor P; Validated; Region: PRK00529 771875001115 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 771875001116 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 771875001117 RNA binding site [nucleotide binding]; other site 771875001118 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 771875001119 RNA binding site [nucleotide binding]; other site 771875001120 Asp23 family; Region: Asp23; pfam03780 771875001121 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 771875001122 putative RNA binding site [nucleotide binding]; other site 771875001123 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 771875001124 dihydropteroate synthase; Region: DHPS; TIGR01496 771875001125 substrate binding pocket [chemical binding]; other site 771875001126 dimer interface [polypeptide binding]; other site 771875001127 inhibitor binding site; inhibition site 771875001128 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 771875001129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 771875001130 RNA binding surface [nucleotide binding]; other site 771875001131 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 771875001132 active site 771875001133 uracil binding [chemical binding]; other site 771875001134 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 771875001135 metal ion-dependent adhesion site (MIDAS); other site 771875001136 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 771875001137 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 771875001138 putative dimer interface [polypeptide binding]; other site 771875001139 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 771875001140 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 771875001141 putative ligand binding site [chemical binding]; other site 771875001142 NAD binding site [chemical binding]; other site 771875001143 dimerization interface [polypeptide binding]; other site 771875001144 catalytic site [active] 771875001145 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 771875001146 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 771875001147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 771875001148 catalytic residue [active] 771875001149 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 771875001150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 771875001151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875001152 homodimer interface [polypeptide binding]; other site 771875001153 catalytic residue [active] 771875001154 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 771875001155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 771875001156 nucleotide binding site [chemical binding]; other site 771875001157 Acetokinase family; Region: Acetate_kinase; cl17229 771875001158 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 771875001159 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 771875001160 nucleotide binding site [chemical binding]; other site 771875001161 Acetokinase family; Region: Acetate_kinase; cl17229 771875001162 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 771875001163 Ferredoxin [Energy production and conversion]; Region: COG1146 771875001164 4Fe-4S binding domain; Region: Fer4; cl02805 771875001165 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 771875001166 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 771875001167 dimer interface [polypeptide binding]; other site 771875001168 PYR/PP interface [polypeptide binding]; other site 771875001169 TPP binding site [chemical binding]; other site 771875001170 substrate binding site [chemical binding]; other site 771875001171 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 771875001172 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 771875001173 TPP-binding site [chemical binding]; other site 771875001174 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 771875001175 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 771875001176 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 771875001177 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 771875001178 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 771875001179 active site 771875001180 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 771875001181 bacterial Hfq-like; Region: Hfq; cd01716 771875001182 hexamer interface [polypeptide binding]; other site 771875001183 Sm1 motif; other site 771875001184 RNA binding site [nucleotide binding]; other site 771875001185 Sm2 motif; other site 771875001186 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 771875001187 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 771875001188 HflX GTPase family; Region: HflX; cd01878 771875001189 G1 box; other site 771875001190 GTP/Mg2+ binding site [chemical binding]; other site 771875001191 Switch I region; other site 771875001192 G2 box; other site 771875001193 G3 box; other site 771875001194 Switch II region; other site 771875001195 G4 box; other site 771875001196 G5 box; other site 771875001197 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 771875001198 Peptidase family M23; Region: Peptidase_M23; pfam01551 771875001199 S-adenosylmethionine synthetase; Validated; Region: PRK05250 771875001200 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 771875001201 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 771875001202 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 771875001203 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 771875001204 HTH-like domain; Region: HTH_21; pfam13276 771875001205 Integrase core domain; Region: rve; pfam00665 771875001206 Integrase core domain; Region: rve_3; cl15866 771875001207 Cache domain; Region: Cache_1; pfam02743 771875001208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 771875001209 dimerization interface [polypeptide binding]; other site 771875001210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 771875001211 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875001212 dimer interface [polypeptide binding]; other site 771875001213 putative CheW interface [polypeptide binding]; other site 771875001214 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 771875001215 active sites [active] 771875001216 tetramer interface [polypeptide binding]; other site 771875001217 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 771875001218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 771875001219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875001220 Coenzyme A binding pocket [chemical binding]; other site 771875001221 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 771875001222 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 771875001223 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 771875001224 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 771875001225 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 771875001226 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 771875001227 active site 771875001228 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 771875001229 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 771875001230 homodimer interface [polypeptide binding]; other site 771875001231 oligonucleotide binding site [chemical binding]; other site 771875001232 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 771875001233 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 771875001234 homotetramer interface [polypeptide binding]; other site 771875001235 ligand binding site [chemical binding]; other site 771875001236 catalytic site [active] 771875001237 NAD binding site [chemical binding]; other site 771875001238 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 771875001239 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 771875001240 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 771875001241 Walker A motif; other site 771875001242 ATP binding site [chemical binding]; other site 771875001243 Walker B motif; other site 771875001244 cell division protein FtsZ; Region: ftsZ; TIGR00065 771875001245 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 771875001246 nucleotide binding site [chemical binding]; other site 771875001247 SulA interaction site; other site 771875001248 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 771875001249 Cell division protein FtsA; Region: FtsA; smart00842 771875001250 Cell division protein FtsA; Region: FtsA; pfam14450 771875001251 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875001252 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875001253 Integrase core domain; Region: rve; pfam00665 771875001254 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 771875001255 Fe-S cluster binding site [ion binding]; other site 771875001256 active site 771875001257 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 771875001258 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 771875001259 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 771875001260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 771875001261 NAD(P) binding site [chemical binding]; other site 771875001262 active site 771875001263 recombination factor protein RarA; Reviewed; Region: PRK13342 771875001264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875001265 Walker A motif; other site 771875001266 ATP binding site [chemical binding]; other site 771875001267 Walker B motif; other site 771875001268 arginine finger; other site 771875001269 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 771875001270 RNase III inhibitor; Provisional; Region: PRK00431 771875001271 ADP-ribose binding site [chemical binding]; other site 771875001272 Uncharacterized conserved protein [Function unknown]; Region: COG1262 771875001273 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 771875001274 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 771875001275 protein binding site [polypeptide binding]; other site 771875001276 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875001277 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875001278 Integrase core domain; Region: rve; pfam00665 771875001279 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 771875001280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 771875001281 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 771875001282 Walker A/P-loop; other site 771875001283 ATP binding site [chemical binding]; other site 771875001284 Q-loop/lid; other site 771875001285 ABC transporter signature motif; other site 771875001286 Walker B; other site 771875001287 D-loop; other site 771875001288 H-loop/switch region; other site 771875001289 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 771875001290 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 771875001291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001292 Walker A/P-loop; other site 771875001293 ATP binding site [chemical binding]; other site 771875001294 Q-loop/lid; other site 771875001295 ABC transporter signature motif; other site 771875001296 Walker B; other site 771875001297 D-loop; other site 771875001298 H-loop/switch region; other site 771875001299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 771875001300 MarR family; Region: MarR; pfam01047 771875001301 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 771875001302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875001303 Walker A motif; other site 771875001304 ATP binding site [chemical binding]; other site 771875001305 Walker B motif; other site 771875001306 arginine finger; other site 771875001307 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 771875001308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 771875001309 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 771875001310 catalytic residue [active] 771875001311 YGGT family; Region: YGGT; pfam02325 771875001312 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 771875001313 ATP-NAD kinase; Region: NAD_kinase; pfam01513 771875001314 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 771875001315 PhoU domain; Region: PhoU; pfam01895 771875001316 Predicted permeases [General function prediction only]; Region: COG0795 771875001317 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 771875001318 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 771875001319 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 771875001320 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 771875001321 Ligand Binding Site [chemical binding]; other site 771875001322 TilS substrate C-terminal domain; Region: TilS_C; smart00977 771875001323 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 771875001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875001325 Walker A motif; other site 771875001326 ATP binding site [chemical binding]; other site 771875001327 Walker B motif; other site 771875001328 arginine finger; other site 771875001329 Peptidase family M41; Region: Peptidase_M41; pfam01434 771875001330 Predicted thioesterase [General function prediction only]; Region: COG5496 771875001331 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 771875001332 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875001333 FeS/SAM binding site; other site 771875001334 Transposase domain (DUF772); Region: DUF772; pfam05598 771875001335 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 771875001336 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 771875001337 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 771875001338 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 771875001339 Walker A/P-loop; other site 771875001340 ATP binding site [chemical binding]; other site 771875001341 Q-loop/lid; other site 771875001342 ABC transporter signature motif; other site 771875001343 Walker B; other site 771875001344 D-loop; other site 771875001345 H-loop/switch region; other site 771875001346 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 771875001347 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 771875001348 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 771875001349 Walker A/P-loop; other site 771875001350 ATP binding site [chemical binding]; other site 771875001351 Q-loop/lid; other site 771875001352 ABC transporter signature motif; other site 771875001353 Walker B; other site 771875001354 D-loop; other site 771875001355 H-loop/switch region; other site 771875001356 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 771875001357 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 771875001358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001359 dimer interface [polypeptide binding]; other site 771875001360 conserved gate region; other site 771875001361 putative PBP binding loops; other site 771875001362 ABC-ATPase subunit interface; other site 771875001363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 771875001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001365 dimer interface [polypeptide binding]; other site 771875001366 conserved gate region; other site 771875001367 putative PBP binding loops; other site 771875001368 ABC-ATPase subunit interface; other site 771875001369 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 771875001370 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 771875001371 substrate binding site [chemical binding]; other site 771875001372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 771875001373 putative DNA binding site [nucleotide binding]; other site 771875001374 putative Zn2+ binding site [ion binding]; other site 771875001375 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 771875001376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 771875001377 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 771875001378 RNA methyltransferase, RsmE family; Region: TIGR00046 771875001379 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 771875001380 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 771875001381 Walker A/P-loop; other site 771875001382 ATP binding site [chemical binding]; other site 771875001383 Q-loop/lid; other site 771875001384 ABC transporter signature motif; other site 771875001385 Walker B; other site 771875001386 D-loop; other site 771875001387 H-loop/switch region; other site 771875001388 TOBE domain; Region: TOBE; pfam03459 771875001389 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 771875001390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875001391 Radical SAM superfamily; Region: Radical_SAM; pfam04055 771875001392 FeS/SAM binding site; other site 771875001393 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 771875001394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 771875001395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 771875001396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875001397 putative substrate translocation pore; other site 771875001398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875001399 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 771875001400 RNA binding site [nucleotide binding]; other site 771875001401 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 771875001402 Heme NO binding; Region: HNOB; pfam07700 771875001403 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 771875001404 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875001405 dimer interface [polypeptide binding]; other site 771875001406 putative CheW interface [polypeptide binding]; other site 771875001407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875001408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875001409 metal binding site [ion binding]; metal-binding site 771875001410 active site 771875001411 I-site; other site 771875001412 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 771875001413 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 771875001414 active site 771875001415 diaminopimelate decarboxylase; Region: lysA; TIGR01048 771875001416 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 771875001417 active site 771875001418 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 771875001419 substrate binding site [chemical binding]; other site 771875001420 catalytic residues [active] 771875001421 dimer interface [polypeptide binding]; other site 771875001422 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 771875001423 active site 771875001424 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 771875001425 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 771875001426 Clp amino terminal domain; Region: Clp_N; pfam02861 771875001427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875001428 Walker A motif; other site 771875001429 ATP binding site [chemical binding]; other site 771875001430 Walker B motif; other site 771875001431 arginine finger; other site 771875001432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875001433 Walker A motif; other site 771875001434 ATP binding site [chemical binding]; other site 771875001435 Walker B motif; other site 771875001436 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 771875001437 DNA repair protein RadA; Provisional; Region: PRK11823 771875001438 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 771875001439 Walker A motif; other site 771875001440 ATP binding site [chemical binding]; other site 771875001441 Walker B motif; other site 771875001442 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 771875001443 EDD domain protein, DegV family; Region: DegV; TIGR00762 771875001444 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 771875001445 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 771875001446 DNA polymerase I; Provisional; Region: PRK05755 771875001447 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 771875001448 active site 771875001449 metal binding site 1 [ion binding]; metal-binding site 771875001450 putative 5' ssDNA interaction site; other site 771875001451 metal binding site 3; metal-binding site 771875001452 metal binding site 2 [ion binding]; metal-binding site 771875001453 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 771875001454 putative DNA binding site [nucleotide binding]; other site 771875001455 putative metal binding site [ion binding]; other site 771875001456 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 771875001457 active site 771875001458 catalytic site [active] 771875001459 substrate binding site [chemical binding]; other site 771875001460 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 771875001461 active site 771875001462 DNA binding site [nucleotide binding] 771875001463 catalytic site [active] 771875001464 EamA-like transporter family; Region: EamA; cl17759 771875001465 EamA-like transporter family; Region: EamA; pfam00892 771875001466 Chromate transporter; Region: Chromate_transp; pfam02417 771875001467 Chromate transporter; Region: Chromate_transp; pfam02417 771875001468 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 771875001469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 771875001470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875001471 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 771875001472 dimer interface [polypeptide binding]; other site 771875001473 putative CheW interface [polypeptide binding]; other site 771875001474 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 771875001475 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 771875001476 FAD binding pocket [chemical binding]; other site 771875001477 FAD binding motif [chemical binding]; other site 771875001478 phosphate binding motif [ion binding]; other site 771875001479 beta-alpha-beta structure motif; other site 771875001480 NAD binding pocket [chemical binding]; other site 771875001481 Iron coordination center [ion binding]; other site 771875001482 putative oxidoreductase; Provisional; Region: PRK12831 771875001483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 771875001484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875001485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875001486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875001487 DNA binding site [nucleotide binding] 771875001488 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875001489 dimerization interface [polypeptide binding]; other site 771875001490 ligand binding site [chemical binding]; other site 771875001491 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 771875001492 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 771875001493 active site 771875001494 catalytic residues [active] 771875001495 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 771875001496 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 771875001497 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 771875001498 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 771875001499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875001500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001501 dimer interface [polypeptide binding]; other site 771875001502 conserved gate region; other site 771875001503 putative PBP binding loops; other site 771875001504 ABC-ATPase subunit interface; other site 771875001505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001506 dimer interface [polypeptide binding]; other site 771875001507 conserved gate region; other site 771875001508 ABC-ATPase subunit interface; other site 771875001509 Tetratricopeptide repeat; Region: TPR_16; pfam13432 771875001510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875001511 binding surface 771875001512 TPR motif; other site 771875001513 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 771875001514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875001515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001516 dimer interface [polypeptide binding]; other site 771875001517 conserved gate region; other site 771875001518 ABC-ATPase subunit interface; other site 771875001519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001520 dimer interface [polypeptide binding]; other site 771875001521 conserved gate region; other site 771875001522 putative PBP binding loops; other site 771875001523 ABC-ATPase subunit interface; other site 771875001524 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 771875001525 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 771875001526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875001527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875001528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875001529 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 771875001530 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 771875001531 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875001532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875001533 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 771875001534 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 771875001535 Cell division protein FtsA; Region: FtsA; smart00842 771875001536 Cell division protein FtsA; Region: FtsA; pfam14450 771875001537 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 771875001538 MutS domain III; Region: MutS_III; pfam05192 771875001539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001540 Walker A/P-loop; other site 771875001541 ATP binding site [chemical binding]; other site 771875001542 Q-loop/lid; other site 771875001543 ABC transporter signature motif; other site 771875001544 Walker B; other site 771875001545 D-loop; other site 771875001546 H-loop/switch region; other site 771875001547 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 771875001548 Smr domain; Region: Smr; pfam01713 771875001549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 771875001550 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 771875001551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 771875001552 metal ion-dependent adhesion site (MIDAS); other site 771875001553 Bacitracin resistance protein BacA; Region: BacA; pfam02673 771875001554 Protein of unknown function (DUF327); Region: DUF327; pfam03885 771875001555 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 771875001556 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 771875001557 Walker A motif; other site 771875001558 ADP-glucose phosphorylase; Region: PLN02643 771875001559 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 771875001560 dimer interface [polypeptide binding]; other site 771875001561 active site 771875001562 glycogen synthase; Provisional; Region: glgA; PRK00654 771875001563 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 771875001564 ADP-binding pocket [chemical binding]; other site 771875001565 homodimer interface [polypeptide binding]; other site 771875001566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 771875001567 Rubredoxin [Energy production and conversion]; Region: COG1773 771875001568 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 771875001569 iron binding site [ion binding]; other site 771875001570 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 771875001571 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 771875001572 active site 771875001573 HIGH motif; other site 771875001574 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 771875001575 active site 771875001576 KMSKS motif; other site 771875001577 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 771875001578 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 771875001579 active site 771875001580 HIGH motif; other site 771875001581 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 771875001582 KMSKS motif; other site 771875001583 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 771875001584 tRNA binding surface [nucleotide binding]; other site 771875001585 anticodon binding site; other site 771875001586 prolyl-tRNA synthetase; Provisional; Region: PRK09194 771875001587 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 771875001588 dimer interface [polypeptide binding]; other site 771875001589 motif 1; other site 771875001590 active site 771875001591 motif 2; other site 771875001592 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 771875001593 putative deacylase active site [active] 771875001594 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 771875001595 active site 771875001596 motif 3; other site 771875001597 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 771875001598 anticodon binding site; other site 771875001599 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 771875001600 hypothetical protein; Reviewed; Region: PRK09588 771875001601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875001603 putative substrate translocation pore; other site 771875001604 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 771875001605 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 771875001606 dimer interface [polypeptide binding]; other site 771875001607 active site 771875001608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 771875001609 catalytic residues [active] 771875001610 substrate binding site [chemical binding]; other site 771875001611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875001612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875001613 metal binding site [ion binding]; metal-binding site 771875001614 active site 771875001615 I-site; other site 771875001616 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14586 771875001617 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 771875001618 dimerization interface 3.5A [polypeptide binding]; other site 771875001619 active site 771875001620 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 771875001621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 771875001622 RNA binding surface [nucleotide binding]; other site 771875001623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875001624 S-adenosylmethionine binding site [chemical binding]; other site 771875001625 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 771875001626 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 771875001627 putative binding surface; other site 771875001628 active site 771875001629 P2 response regulator binding domain; Region: P2; pfam07194 771875001630 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 771875001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875001632 ATP binding site [chemical binding]; other site 771875001633 Mg2+ binding site [ion binding]; other site 771875001634 G-X-G motif; other site 771875001635 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 771875001636 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 771875001637 Response regulator receiver domain; Region: Response_reg; pfam00072 771875001638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875001639 active site 771875001640 phosphorylation site [posttranslational modification] 771875001641 intermolecular recognition site; other site 771875001642 dimerization interface [polypeptide binding]; other site 771875001643 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 771875001644 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 771875001645 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 771875001646 NAD synthetase; Provisional; Region: PRK13981 771875001647 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 771875001648 multimer interface [polypeptide binding]; other site 771875001649 active site 771875001650 catalytic triad [active] 771875001651 protein interface 1 [polypeptide binding]; other site 771875001652 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 771875001653 homodimer interface [polypeptide binding]; other site 771875001654 NAD binding pocket [chemical binding]; other site 771875001655 ATP binding pocket [chemical binding]; other site 771875001656 Mg binding site [ion binding]; other site 771875001657 active-site loop [active] 771875001658 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 771875001659 oxidoreductase; Validated; Region: PRK05717 771875001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 771875001661 NAD(P) binding site [chemical binding]; other site 771875001662 active site 771875001663 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 771875001664 substrate binding site [chemical binding]; other site 771875001665 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 771875001666 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 771875001667 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 771875001668 Ligand Binding Site [chemical binding]; other site 771875001669 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 771875001670 dinuclear metal binding motif [ion binding]; other site 771875001671 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 771875001672 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 771875001673 intersubunit interface [polypeptide binding]; other site 771875001674 active site 771875001675 zinc binding site [ion binding]; other site 771875001676 Na+ binding site [ion binding]; other site 771875001677 propionate/acetate kinase; Provisional; Region: PRK12379 771875001678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 771875001679 nucleotide binding site [chemical binding]; other site 771875001680 butyrate kinase; Provisional; Region: PRK03011 771875001681 Flagellar assembly protein FliH; Region: FliH; pfam02108 771875001682 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 771875001683 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 771875001684 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 771875001685 Walker A motif/ATP binding site; other site 771875001686 Walker B motif; other site 771875001687 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 771875001688 NAD-dependent deacetylase; Provisional; Region: PRK14138 771875001689 NAD+ binding site [chemical binding]; other site 771875001690 substrate binding site [chemical binding]; other site 771875001691 Zn binding site [ion binding]; other site 771875001692 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 771875001693 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 771875001694 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 771875001695 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 771875001696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875001697 active site 771875001698 motif I; other site 771875001699 motif II; other site 771875001700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875001701 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 771875001702 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 771875001703 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14330 771875001704 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 771875001705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875001706 FeS/SAM binding site; other site 771875001707 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 771875001708 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 771875001709 ATP-binding site [chemical binding]; other site 771875001710 Sugar specificity; other site 771875001711 Pyrimidine base specificity; other site 771875001712 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 771875001713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 771875001714 nucleotide binding site [chemical binding]; other site 771875001715 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 771875001716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875001717 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875001718 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875001719 Integrase core domain; Region: rve; pfam00665 771875001720 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875001721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001723 dimer interface [polypeptide binding]; other site 771875001724 conserved gate region; other site 771875001725 putative PBP binding loops; other site 771875001726 ABC-ATPase subunit interface; other site 771875001727 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875001728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001729 dimer interface [polypeptide binding]; other site 771875001730 conserved gate region; other site 771875001731 putative PBP binding loops; other site 771875001732 ABC-ATPase subunit interface; other site 771875001733 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 771875001734 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 771875001735 substrate binding site [chemical binding]; other site 771875001736 ATP binding site [chemical binding]; other site 771875001737 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 771875001738 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 771875001739 putative ADP-binding pocket [chemical binding]; other site 771875001740 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 771875001741 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 771875001742 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 771875001743 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 771875001744 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 771875001745 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 771875001746 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 771875001747 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 771875001748 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 771875001749 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 771875001750 Mg++ binding site [ion binding]; other site 771875001751 putative catalytic motif [active] 771875001752 putative substrate binding site [chemical binding]; other site 771875001753 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 771875001754 Mg++ binding site [ion binding]; other site 771875001755 putative catalytic motif [active] 771875001756 substrate binding site [chemical binding]; other site 771875001757 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 771875001758 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 771875001759 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 771875001760 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 771875001761 dimer interface [polypeptide binding]; other site 771875001762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875001763 catalytic residue [active] 771875001764 serine O-acetyltransferase; Region: cysE; TIGR01172 771875001765 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 771875001766 trimer interface [polypeptide binding]; other site 771875001767 active site 771875001768 substrate binding site [chemical binding]; other site 771875001769 CoA binding site [chemical binding]; other site 771875001770 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 771875001771 metal binding site 2 [ion binding]; metal-binding site 771875001772 putative DNA binding helix; other site 771875001773 metal binding site 1 [ion binding]; metal-binding site 771875001774 dimer interface [polypeptide binding]; other site 771875001775 structural Zn2+ binding site [ion binding]; other site 771875001776 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875001777 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875001778 Integrase core domain; Region: rve; pfam00665 771875001779 Rubrerythrin [Energy production and conversion]; Region: COG1592 771875001780 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 771875001781 binuclear metal center [ion binding]; other site 771875001782 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 771875001783 iron binding site [ion binding]; other site 771875001784 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 771875001785 non-heme iron binding site [ion binding]; other site 771875001786 tetramer interface [polypeptide binding]; other site 771875001787 Protein of unknown function (DUF554); Region: DUF554; pfam04474 771875001788 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 771875001789 Malic enzyme, N-terminal domain; Region: malic; pfam00390 771875001790 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 771875001791 putative NAD(P) binding site [chemical binding]; other site 771875001792 PAS domain S-box; Region: sensory_box; TIGR00229 771875001793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875001794 putative active site [active] 771875001795 heme pocket [chemical binding]; other site 771875001796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875001797 metal binding site [ion binding]; metal-binding site 771875001798 active site 771875001799 I-site; other site 771875001800 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 771875001801 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 771875001802 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 771875001803 FeS assembly ATPase SufC; Region: sufC; TIGR01978 771875001804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001805 Walker A/P-loop; other site 771875001806 ATP binding site [chemical binding]; other site 771875001807 Q-loop/lid; other site 771875001808 ABC transporter signature motif; other site 771875001809 Walker B; other site 771875001810 D-loop; other site 771875001811 H-loop/switch region; other site 771875001812 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 771875001813 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 771875001814 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 771875001815 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 771875001816 transmembrane helices; other site 771875001817 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 771875001818 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 771875001819 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 771875001820 Isochorismatase family; Region: Isochorismatase; pfam00857 771875001821 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 771875001822 catalytic triad [active] 771875001823 conserved cis-peptide bond; other site 771875001824 Mpv17 / PMP22 family; Region: Mpv17_PMP22; pfam04117 771875001825 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 771875001826 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 771875001827 Coenzyme A transferase; Region: CoA_trans; cl17247 771875001828 Coenzyme A transferase; Region: CoA_trans; cl17247 771875001829 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 771875001830 active site 2 [active] 771875001831 active site 1 [active] 771875001832 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 771875001833 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 771875001834 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 771875001835 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 771875001836 NAD(P) binding site [chemical binding]; other site 771875001837 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 771875001838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875001839 FeS/SAM binding site; other site 771875001840 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 771875001841 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 771875001842 dimer interaction site [polypeptide binding]; other site 771875001843 substrate-binding tunnel; other site 771875001844 active site 771875001845 catalytic site [active] 771875001846 substrate binding site [chemical binding]; other site 771875001847 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 771875001848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001849 Walker A/P-loop; other site 771875001850 ATP binding site [chemical binding]; other site 771875001851 Q-loop/lid; other site 771875001852 ABC transporter signature motif; other site 771875001853 Walker B; other site 771875001854 D-loop; other site 771875001855 H-loop/switch region; other site 771875001856 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 771875001857 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 771875001858 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 771875001859 B12 binding site [chemical binding]; other site 771875001860 cobalt ligand [ion binding]; other site 771875001861 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 771875001862 HsdM N-terminal domain; Region: HsdM_N; pfam12161 771875001863 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 771875001864 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 771875001865 Methyltransferase domain; Region: Methyltransf_26; pfam13659 771875001866 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 771875001867 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 771875001868 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 771875001869 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 771875001870 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 771875001871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 771875001872 ATP binding site [chemical binding]; other site 771875001873 putative Mg++ binding site [ion binding]; other site 771875001874 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 771875001875 Protein of unknown function DUF45; Region: DUF45; pfam01863 771875001876 Uncharacterized conserved protein [Function unknown]; Region: COG3339 771875001877 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 771875001878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 771875001879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875001880 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 771875001881 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 771875001882 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 771875001883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 771875001884 ATP binding site [chemical binding]; other site 771875001885 putative Mg++ binding site [ion binding]; other site 771875001886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 771875001887 nucleotide binding region [chemical binding]; other site 771875001888 ATP-binding site [chemical binding]; other site 771875001889 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 771875001890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001891 Walker A/P-loop; other site 771875001892 ATP binding site [chemical binding]; other site 771875001893 SlyX; Region: SlyX; cl01090 771875001894 Syntaxin; Region: Syntaxin; pfam00804 771875001895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001896 Q-loop/lid; other site 771875001897 ABC transporter signature motif; other site 771875001898 Walker B; other site 771875001899 D-loop; other site 771875001900 H-loop/switch region; other site 771875001901 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 771875001902 DNA methylase; Region: N6_N4_Mtase; pfam01555 771875001903 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 771875001904 ATP binding site [chemical binding]; other site 771875001905 putative Mg++ binding site [ion binding]; other site 771875001906 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 771875001907 Predicted permease; Region: DUF318; pfam03773 771875001908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 771875001909 dimerization interface [polypeptide binding]; other site 771875001910 putative DNA binding site [nucleotide binding]; other site 771875001911 putative Zn2+ binding site [ion binding]; other site 771875001912 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875001913 Trp docking motif [polypeptide binding]; other site 771875001914 active site 771875001915 PQQ-like domain; Region: PQQ_2; pfam13360 771875001916 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875001917 Trp docking motif [polypeptide binding]; other site 771875001918 PQQ-like domain; Region: PQQ_2; pfam13360 771875001919 active site 771875001920 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875001921 Trp docking motif [polypeptide binding]; other site 771875001922 active site 771875001923 FOG: WD40-like repeat [Function unknown]; Region: COG1520 771875001924 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875001925 active site 771875001926 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 771875001927 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 771875001928 active site 771875001929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 771875001930 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 771875001931 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 771875001932 active site 771875001933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875001934 putative substrate translocation pore; other site 771875001935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875001936 benzoate transport; Region: 2A0115; TIGR00895 771875001937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875001938 putative substrate translocation pore; other site 771875001939 Probable transposase; Region: OrfB_IS605; pfam01385 771875001940 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 771875001941 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 771875001942 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 771875001943 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 771875001944 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 771875001945 inhibitor-cofactor binding pocket; inhibition site 771875001946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875001947 catalytic residue [active] 771875001948 hypothetical protein; Reviewed; Region: PRK00024 771875001949 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 771875001950 MPN+ (JAMM) motif; other site 771875001951 Zinc-binding site [ion binding]; other site 771875001952 Maf-like protein; Region: Maf; pfam02545 771875001953 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 771875001954 active site 771875001955 dimer interface [polypeptide binding]; other site 771875001956 Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977 771875001957 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 771875001958 Nucleoside recognition; Region: Gate; pfam07670 771875001959 ribonuclease R; Region: RNase_R; TIGR02063 771875001960 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 771875001961 RNB domain; Region: RNB; pfam00773 771875001962 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 771875001963 RNA binding site [nucleotide binding]; other site 771875001964 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 771875001965 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 771875001966 nucleotide binding pocket [chemical binding]; other site 771875001967 K-X-D-G motif; other site 771875001968 catalytic site [active] 771875001969 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 771875001970 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 771875001971 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 771875001972 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 771875001973 Dimer interface [polypeptide binding]; other site 771875001974 BRCT sequence motif; other site 771875001975 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 771875001976 substrate binding site; other site 771875001977 dimer interface; other site 771875001978 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 771875001979 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 771875001980 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875001981 active site 771875001982 metal binding site [ion binding]; metal-binding site 771875001983 homotetramer interface [polypeptide binding]; other site 771875001984 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 771875001985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875001986 active site 771875001987 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875001988 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875001989 Integrase core domain; Region: rve; pfam00665 771875001990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875001991 Walker A/P-loop; other site 771875001992 ATP binding site [chemical binding]; other site 771875001993 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 771875001994 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 771875001995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875001996 dimer interface [polypeptide binding]; other site 771875001997 conserved gate region; other site 771875001998 putative PBP binding loops; other site 771875001999 ABC-ATPase subunit interface; other site 771875002000 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 771875002001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875002002 dimer interface [polypeptide binding]; other site 771875002003 conserved gate region; other site 771875002004 putative PBP binding loops; other site 771875002005 ABC-ATPase subunit interface; other site 771875002006 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 771875002007 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 771875002008 GIY-YIG motif/motif A; other site 771875002009 active site 771875002010 catalytic site [active] 771875002011 putative DNA binding site [nucleotide binding]; other site 771875002012 metal binding site [ion binding]; metal-binding site 771875002013 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 771875002014 CTP synthetase; Validated; Region: pyrG; PRK05380 771875002015 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 771875002016 Catalytic site [active] 771875002017 active site 771875002018 UTP binding site [chemical binding]; other site 771875002019 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 771875002020 active site 771875002021 putative oxyanion hole; other site 771875002022 catalytic triad [active] 771875002023 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 771875002024 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 771875002025 active site 771875002026 elongation factor Ts; Reviewed; Region: tsf; PRK12332 771875002027 UBA/TS-N domain; Region: UBA; pfam00627 771875002028 Elongation factor TS; Region: EF_TS; pfam00889 771875002029 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 771875002030 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 771875002031 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 771875002032 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 771875002033 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 771875002034 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 771875002035 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 771875002036 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 771875002037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 771875002038 NAD(P) binding site [chemical binding]; other site 771875002039 active site 771875002040 Y-family of DNA polymerases; Region: PolY; cl12025 771875002041 RNase_H superfamily; Region: RNase_H_2; pfam13482 771875002042 active site 771875002043 catalytic site [active] 771875002044 substrate binding site [chemical binding]; other site 771875002045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875002046 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 771875002047 TM-ABC transporter signature motif; other site 771875002048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 771875002049 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 771875002050 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 771875002051 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875002052 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 771875002053 TM-ABC transporter signature motif; other site 771875002054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 771875002055 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 771875002056 Walker A/P-loop; other site 771875002057 ATP binding site [chemical binding]; other site 771875002058 Q-loop/lid; other site 771875002059 ABC transporter signature motif; other site 771875002060 Walker B; other site 771875002061 D-loop; other site 771875002062 H-loop/switch region; other site 771875002063 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 771875002064 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 771875002065 Walker A/P-loop; other site 771875002066 ATP binding site [chemical binding]; other site 771875002067 Q-loop/lid; other site 771875002068 ABC transporter signature motif; other site 771875002069 Walker B; other site 771875002070 D-loop; other site 771875002071 H-loop/switch region; other site 771875002072 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 771875002073 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 771875002074 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 771875002075 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 771875002076 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 771875002077 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 771875002078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 771875002079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 771875002080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 771875002081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 771875002082 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 771875002083 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 771875002084 dimer interface [polypeptide binding]; other site 771875002085 active site 771875002086 CoA binding pocket [chemical binding]; other site 771875002087 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 771875002088 FMN binding site [chemical binding]; other site 771875002089 dimer interface [polypeptide binding]; other site 771875002090 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 771875002091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875002092 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 771875002093 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 771875002094 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 771875002095 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 771875002096 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 771875002097 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 771875002098 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 771875002099 substrate binding site [chemical binding]; other site 771875002100 ATP binding site [chemical binding]; other site 771875002101 Putative aldolase; Region: Aldolase_2; pfam10120 771875002102 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 771875002103 30S subunit binding site; other site 771875002104 EDD domain protein, DegV family; Region: DegV; TIGR00762 771875002105 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 771875002106 EDD domain protein, DegV family; Region: DegV; TIGR00762 771875002107 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 771875002108 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 771875002109 gamma subunit interface [polypeptide binding]; other site 771875002110 epsilon subunit interface [polypeptide binding]; other site 771875002111 LBP interface [polypeptide binding]; other site 771875002112 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 771875002113 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 771875002114 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 771875002115 alpha subunit interaction interface [polypeptide binding]; other site 771875002116 Walker A motif; other site 771875002117 ATP binding site [chemical binding]; other site 771875002118 Walker B motif; other site 771875002119 inhibitor binding site; inhibition site 771875002120 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 771875002121 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 771875002122 core domain interface [polypeptide binding]; other site 771875002123 delta subunit interface [polypeptide binding]; other site 771875002124 epsilon subunit interface [polypeptide binding]; other site 771875002125 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 771875002126 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 771875002127 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 771875002128 beta subunit interaction interface [polypeptide binding]; other site 771875002129 Walker A motif; other site 771875002130 ATP binding site [chemical binding]; other site 771875002131 Walker B motif; other site 771875002132 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 771875002133 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 771875002134 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 771875002135 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 771875002136 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 771875002137 F0F1 ATP synthase subunit C; Provisional; Region: PRK13471 771875002138 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 771875002139 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 771875002140 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 771875002141 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 771875002142 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 771875002143 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 771875002144 active site 771875002145 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 771875002146 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 771875002147 DHH family; Region: DHH; pfam01368 771875002148 DHHA1 domain; Region: DHHA1; pfam02272 771875002149 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 771875002150 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 771875002151 active site 771875002152 glyoxylate reductase; Reviewed; Region: PRK13243 771875002153 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 771875002154 dimerization interface [polypeptide binding]; other site 771875002155 ligand binding site [chemical binding]; other site 771875002156 NADP binding site [chemical binding]; other site 771875002157 catalytic site [active] 771875002158 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 771875002159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 771875002160 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 771875002161 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 771875002162 lipoprotein signal peptidase; Provisional; Region: PRK14786 771875002163 lipoprotein signal peptidase; Provisional; Region: PRK14787 771875002164 Heavy-metal-associated domain; Region: HMA; pfam00403 771875002165 metal-binding site [ion binding] 771875002166 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 771875002167 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 771875002168 metal-binding site [ion binding] 771875002169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 771875002170 Soluble P-type ATPase [General function prediction only]; Region: COG4087 771875002171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 771875002172 dimerization interface [polypeptide binding]; other site 771875002173 putative DNA binding site [nucleotide binding]; other site 771875002174 putative Zn2+ binding site [ion binding]; other site 771875002175 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 771875002176 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 771875002177 catalytic residues [active] 771875002178 catalytic nucleophile [active] 771875002179 Recombinase; Region: Recombinase; pfam07508 771875002180 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 771875002181 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 771875002182 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 771875002183 FAD binding pocket [chemical binding]; other site 771875002184 FAD binding motif [chemical binding]; other site 771875002185 phosphate binding motif [ion binding]; other site 771875002186 beta-alpha-beta structure motif; other site 771875002187 NAD binding pocket [chemical binding]; other site 771875002188 Iron coordination center [ion binding]; other site 771875002189 putative oxidoreductase; Provisional; Region: PRK12831 771875002190 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 771875002191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 771875002192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875002193 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 771875002194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875002195 FeS/SAM binding site; other site 771875002196 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 771875002197 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 771875002198 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 771875002199 Walker A/P-loop; other site 771875002200 ATP binding site [chemical binding]; other site 771875002201 Q-loop/lid; other site 771875002202 ABC transporter signature motif; other site 771875002203 Walker B; other site 771875002204 D-loop; other site 771875002205 H-loop/switch region; other site 771875002206 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 771875002207 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 771875002208 ABC-2 type transporter; Region: ABC2_membrane; cl17235 771875002209 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875002210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875002211 DNA binding site [nucleotide binding] 771875002212 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875002213 dimerization interface [polypeptide binding]; other site 771875002214 ligand binding site [chemical binding]; other site 771875002215 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 771875002216 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 771875002217 active site 771875002218 catalytic residues [active] 771875002219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 771875002220 Integrase core domain; Region: rve; pfam00665 771875002221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875002222 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 771875002223 Walker A motif; other site 771875002224 ATP binding site [chemical binding]; other site 771875002225 Walker B motif; other site 771875002226 arginine finger; other site 771875002227 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 771875002228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 771875002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875002230 dimer interface [polypeptide binding]; other site 771875002231 conserved gate region; other site 771875002232 ABC-ATPase subunit interface; other site 771875002233 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 771875002234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 771875002235 ABC transporter; Region: ABC_tran_2; pfam12848 771875002236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 771875002237 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 771875002238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875002239 Coenzyme A binding pocket [chemical binding]; other site 771875002240 endonuclease IV; Provisional; Region: PRK01060 771875002241 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 771875002242 AP (apurinic/apyrimidinic) site pocket; other site 771875002243 DNA interaction; other site 771875002244 Metal-binding active site; metal-binding site 771875002245 NAD synthetase; Provisional; Region: PRK13981 771875002246 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 771875002247 multimer interface [polypeptide binding]; other site 771875002248 active site 771875002249 catalytic triad [active] 771875002250 protein interface 1 [polypeptide binding]; other site 771875002251 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 771875002252 homodimer interface [polypeptide binding]; other site 771875002253 NAD binding pocket [chemical binding]; other site 771875002254 ATP binding pocket [chemical binding]; other site 771875002255 Mg binding site [ion binding]; other site 771875002256 active-site loop [active] 771875002257 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002258 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002259 Integrase core domain; Region: rve; pfam00665 771875002260 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 771875002261 Thiamine pyrophosphokinase; Region: TPK; cd07995 771875002262 active site 771875002263 dimerization interface [polypeptide binding]; other site 771875002264 thiamine binding site [chemical binding]; other site 771875002265 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 771875002266 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 771875002267 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 771875002268 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 771875002269 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 771875002270 active site 771875002271 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 771875002272 protein binding site [polypeptide binding]; other site 771875002273 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 771875002274 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 771875002275 putative substrate binding region [chemical binding]; other site 771875002276 GcpE protein; Region: GcpE; pfam04551 771875002277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 771875002278 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 771875002279 stationary phase survival protein SurE; Provisional; Region: PRK13935 771875002280 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 771875002281 active site 771875002282 catalytic residues [active] 771875002283 metal binding site [ion binding]; metal-binding site 771875002284 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 771875002285 PQQ-like domain; Region: PQQ_2; pfam13360 771875002286 Beta-propeller repeat; Region: SBBP; pfam06739 771875002287 Beta-propeller repeat; Region: SBBP; pfam06739 771875002288 Beta-propeller repeat; Region: SBBP; pfam06739 771875002289 Beta-propeller repeat; Region: SBBP; pfam06739 771875002290 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 771875002291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875002292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 771875002293 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 771875002294 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 771875002295 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 771875002296 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 771875002297 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 771875002298 serine O-acetyltransferase; Region: cysE; TIGR01172 771875002299 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 771875002300 trimer interface [polypeptide binding]; other site 771875002301 active site 771875002302 substrate binding site [chemical binding]; other site 771875002303 CoA binding site [chemical binding]; other site 771875002304 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 771875002305 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 771875002306 dimer interface [polypeptide binding]; other site 771875002307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875002308 catalytic residue [active] 771875002309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 771875002310 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 771875002311 FAD binding site [chemical binding]; other site 771875002312 homotetramer interface [polypeptide binding]; other site 771875002313 substrate binding pocket [chemical binding]; other site 771875002314 catalytic base [active] 771875002315 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 771875002316 Ligand binding site [chemical binding]; other site 771875002317 Electron transfer flavoprotein domain; Region: ETF; pfam01012 771875002318 Electron transfer flavoprotein domain; Region: ETF; pfam01012 771875002319 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 771875002320 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 771875002321 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002322 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002323 Integrase core domain; Region: rve; pfam00665 771875002324 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875002325 Trp docking motif [polypeptide binding]; other site 771875002326 active site 771875002327 FOG: WD40-like repeat [Function unknown]; Region: COG1520 771875002328 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875002329 Trp docking motif [polypeptide binding]; other site 771875002330 active site 771875002331 FOG: WD40-like repeat [Function unknown]; Region: COG1520 771875002332 Predicted integral membrane protein [Function unknown]; Region: COG5652 771875002333 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 771875002334 Protein of unknown function DUF58; Region: DUF58; pfam01882 771875002335 GMP synthase; Reviewed; Region: guaA; PRK00074 771875002336 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 771875002337 AMP/PPi binding site [chemical binding]; other site 771875002338 candidate oxyanion hole; other site 771875002339 catalytic triad [active] 771875002340 potential glutamine specificity residues [chemical binding]; other site 771875002341 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 771875002342 ATP Binding subdomain [chemical binding]; other site 771875002343 Ligand Binding sites [chemical binding]; other site 771875002344 Dimerization subdomain; other site 771875002345 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 771875002346 metal-dependent hydrolase; Provisional; Region: PRK00685 771875002347 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002348 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002349 Integrase core domain; Region: rve; pfam00665 771875002350 putative oxidoreductase; Provisional; Region: PRK12831 771875002351 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 771875002352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 771875002353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875002354 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 771875002355 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 771875002356 FAD binding pocket [chemical binding]; other site 771875002357 FAD binding motif [chemical binding]; other site 771875002358 phosphate binding motif [ion binding]; other site 771875002359 beta-alpha-beta structure motif; other site 771875002360 NAD binding pocket [chemical binding]; other site 771875002361 Iron coordination center [ion binding]; other site 771875002362 transcription termination factor Rho; Provisional; Region: rho; PRK09376 771875002363 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 771875002364 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 771875002365 RNA binding site [nucleotide binding]; other site 771875002366 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 771875002367 multimer interface [polypeptide binding]; other site 771875002368 Walker A motif; other site 771875002369 ATP binding site [chemical binding]; other site 771875002370 Walker B motif; other site 771875002371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875002372 active site 771875002373 peptide chain release factor 1; Validated; Region: prfA; PRK00591 771875002374 This domain is found in peptide chain release factors; Region: PCRF; smart00937 771875002375 RF-1 domain; Region: RF-1; pfam00472 771875002376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 771875002377 Integrase core domain; Region: rve; pfam00665 771875002378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875002379 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 771875002380 Walker A motif; other site 771875002381 ATP binding site [chemical binding]; other site 771875002382 Walker B motif; other site 771875002383 arginine finger; other site 771875002384 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 771875002385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875002386 Walker A motif; other site 771875002387 ATP binding site [chemical binding]; other site 771875002388 Walker B motif; other site 771875002389 arginine finger; other site 771875002390 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 771875002391 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 771875002392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875002393 motif II; other site 771875002394 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 771875002395 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 771875002396 Ligand binding site; other site 771875002397 Transcriptional regulator [Transcription]; Region: LytR; COG1316 771875002398 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 771875002399 active site 771875002400 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 771875002401 homodimer interface [polypeptide binding]; other site 771875002402 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 771875002403 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 771875002404 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 771875002405 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 771875002406 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 771875002407 ATP-grasp domain; Region: ATP-grasp_4; cl17255 771875002408 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 771875002409 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 771875002410 phage shock protein A; Region: phageshock_pspA; TIGR02977 771875002411 Predicted ATPase [General function prediction only]; Region: COG5293 771875002412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 771875002413 DEAD-like helicases superfamily; Region: DEXDc; smart00487 771875002414 ATP binding site [chemical binding]; other site 771875002415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 771875002416 putative Mg++ binding site [ion binding]; other site 771875002417 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 771875002418 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875002419 putative active site [active] 771875002420 putative metal binding site [ion binding]; other site 771875002421 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 771875002422 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 771875002423 catalytic residues [active] 771875002424 catalytic nucleophile [active] 771875002425 Recombinase; Region: Recombinase; pfam07508 771875002426 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 771875002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875002428 S-adenosylmethionine binding site [chemical binding]; other site 771875002429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875002430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875002431 putative substrate translocation pore; other site 771875002432 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875002433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875002434 metal binding site [ion binding]; metal-binding site 771875002435 I-site; other site 771875002436 active site 771875002437 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 771875002438 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 771875002439 active site 771875002440 HIGH motif; other site 771875002441 nucleotide binding site [chemical binding]; other site 771875002442 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 771875002443 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 771875002444 active site 771875002445 KMSKS motif; other site 771875002446 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 771875002447 tRNA binding surface [nucleotide binding]; other site 771875002448 anticodon binding site; other site 771875002449 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 771875002450 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 771875002451 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 771875002452 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 771875002453 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 771875002454 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 771875002455 active site 771875002456 putative substrate binding pocket [chemical binding]; other site 771875002457 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 771875002458 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 771875002459 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002460 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002461 Integrase core domain; Region: rve; pfam00665 771875002462 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 771875002463 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 771875002464 dimer interface [polypeptide binding]; other site 771875002465 catalytic triad [active] 771875002466 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 771875002467 Ferritin-like domain; Region: Ferritin; pfam00210 771875002468 ferroxidase diiron center [ion binding]; other site 771875002469 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 771875002470 Active_site [active] 771875002471 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 771875002472 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 771875002473 transmembrane helices; other site 771875002474 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 771875002475 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 771875002476 transmembrane helices; other site 771875002477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 771875002478 TPR repeat; Region: TPR_11; pfam13414 771875002479 TPR motif; other site 771875002480 binding surface 771875002481 transcription termination factor Rho; Provisional; Region: rho; PRK09376 771875002482 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 771875002483 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 771875002484 RNA binding site [nucleotide binding]; other site 771875002485 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 771875002486 multimer interface [polypeptide binding]; other site 771875002487 Walker A motif; other site 771875002488 ATP binding site [chemical binding]; other site 771875002489 Walker B motif; other site 771875002490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875002491 active site 771875002492 peptide chain release factor 1; Validated; Region: prfA; PRK00591 771875002493 This domain is found in peptide chain release factors; Region: PCRF; smart00937 771875002494 RF-1 domain; Region: RF-1; pfam00472 771875002495 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 771875002496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875002497 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 771875002498 Walker A motif; other site 771875002499 Walker A/P-loop; other site 771875002500 ATP binding site [chemical binding]; other site 771875002501 ATP binding site [chemical binding]; other site 771875002502 Walker B motif; other site 771875002503 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 771875002504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875002505 Walker A motif; other site 771875002506 ATP binding site [chemical binding]; other site 771875002507 DNA polymerase III subunit delta'; Validated; Region: PRK08485 771875002508 Walker B motif; other site 771875002509 arginine finger; other site 771875002510 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 771875002511 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 771875002512 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 771875002513 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 771875002514 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 771875002515 active site 771875002516 nucleophile elbow; other site 771875002517 S-layer homology domain; Region: SLH; pfam00395 771875002518 PEGA domain; Region: PEGA; pfam08308 771875002519 PEGA domain; Region: PEGA; pfam08308 771875002520 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 771875002521 MarR family; Region: MarR; pfam01047 771875002522 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 771875002523 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 771875002524 oligomer interface [polypeptide binding]; other site 771875002525 putative active site [active] 771875002526 metal binding site [ion binding]; metal-binding site 771875002527 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14653 771875002528 FAD binding domain; Region: FAD_binding_4; pfam01565 771875002529 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 771875002530 AAA ATPase domain; Region: AAA_16; pfam13191 771875002531 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875002532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875002533 metal binding site [ion binding]; metal-binding site 771875002534 active site 771875002535 I-site; other site 771875002536 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875002537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875002538 metal binding site [ion binding]; metal-binding site 771875002539 active site 771875002540 I-site; other site 771875002541 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 771875002542 DHH family; Region: DHH; pfam01368 771875002543 DHHA1 domain; Region: DHHA1; pfam02272 771875002544 purine nucleoside phosphorylase; Provisional; Region: PRK08202 771875002545 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 771875002546 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 771875002547 dimer interface [polypeptide binding]; other site 771875002548 active site 771875002549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 771875002550 substrate binding site [chemical binding]; other site 771875002551 catalytic residue [active] 771875002552 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 771875002553 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 771875002554 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 771875002555 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 771875002556 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 771875002557 FeoA domain; Region: FeoA; pfam04023 771875002558 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 771875002559 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 771875002560 G1 box; other site 771875002561 GTP/Mg2+ binding site [chemical binding]; other site 771875002562 Switch I region; other site 771875002563 G2 box; other site 771875002564 G3 box; other site 771875002565 Switch II region; other site 771875002566 G4 box; other site 771875002567 G5 box; other site 771875002568 Nucleoside recognition; Region: Gate; pfam07670 771875002569 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 771875002570 Nucleoside recognition; Region: Gate; pfam07670 771875002571 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 771875002572 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 771875002573 intersubunit interface [polypeptide binding]; other site 771875002574 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 771875002575 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 771875002576 ABC-ATPase subunit interface; other site 771875002577 dimer interface [polypeptide binding]; other site 771875002578 putative PBP binding regions; other site 771875002579 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 771875002580 catalytic motif [active] 771875002581 Zn binding site [ion binding]; other site 771875002582 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 771875002583 RibD C-terminal domain; Region: RibD_C; pfam01872 771875002584 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 771875002585 Lumazine binding domain; Region: Lum_binding; pfam00677 771875002586 Lumazine binding domain; Region: Lum_binding; pfam00677 771875002587 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09318 771875002588 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 771875002589 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 771875002590 dimerization interface [polypeptide binding]; other site 771875002591 active site 771875002592 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 771875002593 homopentamer interface [polypeptide binding]; other site 771875002594 active site 771875002595 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 771875002596 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 771875002597 Walker A/P-loop; other site 771875002598 ATP binding site [chemical binding]; other site 771875002599 Q-loop/lid; other site 771875002600 ABC transporter signature motif; other site 771875002601 Walker B; other site 771875002602 D-loop; other site 771875002603 H-loop/switch region; other site 771875002604 Predicted permease (DUF2074); Region: DUF2074; cl15401 771875002605 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 771875002606 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002607 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002608 Integrase core domain; Region: rve; pfam00665 771875002609 Predicted membrane protein [Function unknown]; Region: COG3462 771875002610 Short C-terminal domain; Region: SHOCT; pfam09851 771875002611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 771875002612 Putative glucoamylase; Region: Glycoamylase; pfam10091 771875002613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 771875002614 Putative glucoamylase; Region: Glycoamylase; pfam10091 771875002615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875002616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875002617 dimer interface [polypeptide binding]; other site 771875002618 conserved gate region; other site 771875002619 putative PBP binding loops; other site 771875002620 ABC-ATPase subunit interface; other site 771875002621 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 771875002622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 771875002623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875002624 putative PBP binding loops; other site 771875002625 dimer interface [polypeptide binding]; other site 771875002626 ABC-ATPase subunit interface; other site 771875002627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875002628 TPR motif; other site 771875002629 binding surface 771875002630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875002631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875002632 dimer interface [polypeptide binding]; other site 771875002633 conserved gate region; other site 771875002634 ABC-ATPase subunit interface; other site 771875002635 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 771875002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875002637 dimer interface [polypeptide binding]; other site 771875002638 conserved gate region; other site 771875002639 putative PBP binding loops; other site 771875002640 ABC-ATPase subunit interface; other site 771875002641 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 771875002642 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875002643 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875002644 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 771875002645 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875002646 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 771875002647 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 771875002648 Protein of unknown function, DUF608; Region: DUF608; pfam04685 771875002649 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 771875002650 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 771875002651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875002652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875002653 DNA binding site [nucleotide binding] 771875002654 domain linker motif; other site 771875002655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875002656 dimerization interface [polypeptide binding]; other site 771875002657 ligand binding site [chemical binding]; other site 771875002658 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 771875002659 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 771875002660 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 771875002661 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 771875002662 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 771875002663 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 771875002664 putative ligand binding site [chemical binding]; other site 771875002665 NAD binding site [chemical binding]; other site 771875002666 dimer interface [polypeptide binding]; other site 771875002667 putative catalytic site [active] 771875002668 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 771875002669 Domain of unknown function (DUF814); Region: DUF814; pfam05670 771875002670 excinuclease ABC subunit B; Provisional; Region: PRK05298 771875002671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 771875002672 ATP binding site [chemical binding]; other site 771875002673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 771875002674 nucleotide binding region [chemical binding]; other site 771875002675 ATP-binding site [chemical binding]; other site 771875002676 Ultra-violet resistance protein B; Region: UvrB; pfam12344 771875002677 UvrB/uvrC motif; Region: UVR; pfam02151 771875002678 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 771875002679 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 771875002680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875002681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 771875002682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 771875002683 dimerization interface [polypeptide binding]; other site 771875002684 putative DNA binding site [nucleotide binding]; other site 771875002685 putative Zn2+ binding site [ion binding]; other site 771875002686 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 771875002687 CPxP motif; other site 771875002688 DsrH like protein; Region: DsrH; pfam04077 771875002689 DsrE/DsrF-like family; Region: DrsE; cl00672 771875002690 DsrE/DsrF-like family; Region: DrsE; cl00672 771875002691 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 771875002692 Sulphur transport; Region: Sulf_transp; pfam04143 771875002693 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 771875002694 CPxP motif; other site 771875002695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875002696 putative substrate translocation pore; other site 771875002697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875002698 hypothetical protein; Provisional; Region: PRK00967 771875002699 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 771875002700 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 771875002701 Walker A/P-loop; other site 771875002702 ATP binding site [chemical binding]; other site 771875002703 Q-loop/lid; other site 771875002704 ABC transporter signature motif; other site 771875002705 Walker B; other site 771875002706 D-loop; other site 771875002707 H-loop/switch region; other site 771875002708 Predicted transcriptional regulators [Transcription]; Region: COG1725 771875002709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 771875002710 DNA-binding site [nucleotide binding]; DNA binding site 771875002711 dihydroorotase; Validated; Region: pyrC; PRK09357 771875002712 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 771875002713 active site 771875002714 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 771875002715 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 771875002716 FAD binding pocket [chemical binding]; other site 771875002717 FAD binding motif [chemical binding]; other site 771875002718 phosphate binding motif [ion binding]; other site 771875002719 beta-alpha-beta structure motif; other site 771875002720 NAD binding pocket [chemical binding]; other site 771875002721 Iron coordination center [ion binding]; other site 771875002722 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 771875002723 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 771875002724 phosphate binding site [ion binding]; other site 771875002725 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 771875002726 active site 771875002727 dimer interface [polypeptide binding]; other site 771875002728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875002729 active site 771875002730 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 771875002731 intersubunit interface [polypeptide binding]; other site 771875002732 active site 771875002733 Zn2+ binding site [ion binding]; other site 771875002734 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 771875002735 galactokinase; Provisional; Region: PRK03817 771875002736 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 771875002737 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 771875002738 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 771875002739 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 771875002740 dimer interface [polypeptide binding]; other site 771875002741 active site 771875002742 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 771875002743 Melibiase; Region: Melibiase; pfam02065 771875002744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875002745 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875002746 DNA binding site [nucleotide binding] 771875002747 domain linker motif; other site 771875002748 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875002749 dimerization interface [polypeptide binding]; other site 771875002750 ligand binding site [chemical binding]; other site 771875002751 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 771875002752 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 771875002753 H+ Antiporter protein; Region: 2A0121; TIGR00900 771875002754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875002755 putative substrate translocation pore; other site 771875002756 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 771875002757 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 771875002758 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 771875002759 active site 771875002760 dimer interface [polypeptide binding]; other site 771875002761 effector binding site; other site 771875002762 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 771875002763 TSCPD domain; Region: TSCPD; pfam12637 771875002764 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 771875002765 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 771875002766 CoA binding domain; Region: CoA_binding; smart00881 771875002767 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002768 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002769 Integrase core domain; Region: rve; pfam00665 771875002770 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 771875002771 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875002772 dimer interface [polypeptide binding]; other site 771875002773 [2Fe-2S] cluster binding site [ion binding]; other site 771875002774 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 771875002775 4Fe-4S binding domain; Region: Fer4; pfam00037 771875002776 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 771875002777 Predicted Fe-S protein [General function prediction only]; Region: COG2000 771875002778 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 771875002779 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 771875002780 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 771875002781 putative dimer interface [polypeptide binding]; other site 771875002782 [2Fe-2S] cluster binding site [ion binding]; other site 771875002783 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875002784 dimer interface [polypeptide binding]; other site 771875002785 [2Fe-2S] cluster binding site [ion binding]; other site 771875002786 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 771875002787 SLBB domain; Region: SLBB; pfam10531 771875002788 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 771875002789 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 771875002790 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 771875002791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 771875002792 catalytic loop [active] 771875002793 iron binding site [ion binding]; other site 771875002794 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 771875002795 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 771875002796 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 771875002797 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 771875002798 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 771875002799 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875002800 dimer interface [polypeptide binding]; other site 771875002801 [2Fe-2S] cluster binding site [ion binding]; other site 771875002802 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 771875002803 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 771875002804 CoA binding domain; Region: CoA_binding; smart00881 771875002805 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 771875002806 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 771875002807 active site 771875002808 Zn binding site [ion binding]; other site 771875002809 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 771875002810 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 771875002811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 771875002812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875002813 Walker A motif; other site 771875002814 ATP binding site [chemical binding]; other site 771875002815 Walker B motif; other site 771875002816 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 771875002817 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 771875002818 putative active site [active] 771875002819 putative CoA binding site [chemical binding]; other site 771875002820 nudix motif; other site 771875002821 metal binding site [ion binding]; metal-binding site 771875002822 PQQ-like domain; Region: PQQ_2; pfam13360 771875002823 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875002824 active site 771875002825 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 771875002826 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 771875002827 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 771875002828 putative RNA binding site [nucleotide binding]; other site 771875002829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875002830 S-adenosylmethionine binding site [chemical binding]; other site 771875002831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 771875002832 catalytic loop [active] 771875002833 iron binding site [ion binding]; other site 771875002834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 771875002835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 771875002836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875002837 4Fe-4S binding domain; Region: Fer4; pfam00037 771875002838 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 771875002839 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 771875002840 hydroxyglutarate oxidase; Provisional; Region: PRK11728 771875002841 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 771875002842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875002843 active site 771875002844 phosphorylation site [posttranslational modification] 771875002845 intermolecular recognition site; other site 771875002846 dimerization interface [polypeptide binding]; other site 771875002847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875002848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875002849 metal binding site [ion binding]; metal-binding site 771875002850 active site 771875002851 I-site; other site 771875002852 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 771875002853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875002854 H+ Antiporter protein; Region: 2A0121; TIGR00900 771875002855 putative substrate translocation pore; other site 771875002856 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 771875002857 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 771875002858 oligomer interface [polypeptide binding]; other site 771875002859 active site 771875002860 metal binding site [ion binding]; metal-binding site 771875002861 hypothetical protein; Provisional; Region: PRK10621 771875002862 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 771875002863 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 771875002864 putative active site [active] 771875002865 catalytic residue [active] 771875002866 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 771875002867 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 771875002868 5S rRNA interface [nucleotide binding]; other site 771875002869 CTC domain interface [polypeptide binding]; other site 771875002870 L16 interface [polypeptide binding]; other site 771875002871 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 771875002872 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 771875002873 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875002874 active site 771875002875 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14357 771875002876 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 771875002877 Substrate binding site; other site 771875002878 Mg++ binding site; other site 771875002879 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 771875002880 active site 771875002881 substrate binding site [chemical binding]; other site 771875002882 CoA binding site [chemical binding]; other site 771875002883 pyruvate phosphate dikinase; Provisional; Region: PRK09279 771875002884 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 771875002885 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 771875002886 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 771875002887 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 771875002888 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 771875002889 NAD(P) binding site [chemical binding]; other site 771875002890 homotetramer interface [polypeptide binding]; other site 771875002891 homodimer interface [polypeptide binding]; other site 771875002892 active site 771875002893 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 771875002894 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 771875002895 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 771875002896 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 771875002897 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 771875002898 FMN binding site [chemical binding]; other site 771875002899 substrate binding site [chemical binding]; other site 771875002900 putative catalytic residue [active] 771875002901 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 771875002902 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 771875002903 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 771875002904 dimer interface [polypeptide binding]; other site 771875002905 active site 771875002906 EDD domain protein, DegV family; Region: DegV; TIGR00762 771875002907 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 771875002908 acyl carrier protein; Provisional; Region: acpP; PRK00982 771875002909 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 771875002910 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 771875002911 active site 771875002912 catalytic site [active] 771875002913 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 771875002914 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 771875002915 ligand binding site [chemical binding]; other site 771875002916 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 771875002917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875002918 Zn2+ binding site [ion binding]; other site 771875002919 Mg2+ binding site [ion binding]; other site 771875002920 Tetratricopeptide repeat; Region: TPR_16; pfam13432 771875002921 putative GTP cyclohydrolase; Provisional; Region: PRK13674 771875002922 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 771875002923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 771875002924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875002925 Coenzyme A binding pocket [chemical binding]; other site 771875002926 Stage II sporulation protein; Region: SpoIID; pfam08486 771875002927 Asp23 family; Region: Asp23; cl00574 771875002928 Asp23 family; Region: Asp23; pfam03780 771875002929 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 771875002930 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 771875002931 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 771875002932 FMN-binding domain; Region: FMN_bind; cl01081 771875002933 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 771875002934 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875002935 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875002936 Integrase core domain; Region: rve; pfam00665 771875002937 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 771875002938 metal-dependent hydrolase; Provisional; Region: PRK00685 771875002939 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 771875002940 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 771875002941 ATP binding site [chemical binding]; other site 771875002942 Mg++ binding site [ion binding]; other site 771875002943 motif III; other site 771875002944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 771875002945 nucleotide binding region [chemical binding]; other site 771875002946 ATP-binding site [chemical binding]; other site 771875002947 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 771875002948 RNA binding site [nucleotide binding]; other site 771875002949 Isochorismatase family; Region: Isochorismatase; pfam00857 771875002950 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 771875002951 catalytic triad [active] 771875002952 conserved cis-peptide bond; other site 771875002953 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 771875002954 HTH domain; Region: HTH_11; pfam08279 771875002955 3H domain; Region: 3H; pfam02829 771875002956 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 771875002957 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 771875002958 active site 771875002959 metal binding site [ion binding]; metal-binding site 771875002960 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 771875002961 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 771875002962 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 771875002963 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 771875002964 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 771875002965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875002966 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 771875002967 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 771875002968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875002969 putative substrate translocation pore; other site 771875002970 signal recognition particle protein; Provisional; Region: PRK10867 771875002971 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 771875002972 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 771875002973 P loop; other site 771875002974 GTP binding site [chemical binding]; other site 771875002975 Signal peptide binding domain; Region: SRP_SPB; pfam02978 771875002976 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14524 771875002977 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 771875002978 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 771875002979 G-X-X-G motif; other site 771875002980 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 771875002981 RimM N-terminal domain; Region: RimM; pfam01782 771875002982 PRC-barrel domain; Region: PRC; pfam05239 771875002983 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 771875002984 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 771875002985 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 771875002986 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 771875002987 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 771875002988 Catalytic site [active] 771875002989 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 771875002990 FOG: CBS domain [General function prediction only]; Region: COG0517 771875002991 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 771875002992 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 771875002993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875002994 ATP binding site [chemical binding]; other site 771875002995 Mg2+ binding site [ion binding]; other site 771875002996 G-X-G motif; other site 771875002997 CoA binding domain; Region: CoA_binding_2; pfam13380 771875002998 HD domain; Region: HD; pfam01966 771875002999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875003000 Zn2+ binding site [ion binding]; other site 771875003001 Mg2+ binding site [ion binding]; other site 771875003002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 771875003003 Sm and related proteins; Region: Sm_like; cl00259 771875003004 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 771875003005 putative oligomer interface [polypeptide binding]; other site 771875003006 putative RNA binding site [nucleotide binding]; other site 771875003007 transcription termination factor NusA; Region: NusA; TIGR01953 771875003008 NusA N-terminal domain; Region: NusA_N; pfam08529 771875003009 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 771875003010 RNA binding site [nucleotide binding]; other site 771875003011 homodimer interface [polypeptide binding]; other site 771875003012 NusA-like KH domain; Region: KH_5; pfam13184 771875003013 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 771875003014 G-X-X-G motif; other site 771875003015 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 771875003016 metal binding site 2 [ion binding]; metal-binding site 771875003017 putative DNA binding helix; other site 771875003018 metal binding site 1 [ion binding]; metal-binding site 771875003019 dimer interface [polypeptide binding]; other site 771875003020 structural Zn2+ binding site [ion binding]; other site 771875003021 Competence protein; Region: Competence; pfam03772 771875003022 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 771875003023 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 771875003024 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 771875003025 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 771875003026 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 771875003027 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 771875003028 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 771875003029 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 771875003030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875003031 Zn2+ binding site [ion binding]; other site 771875003032 Mg2+ binding site [ion binding]; other site 771875003033 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 771875003034 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 771875003035 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 771875003036 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 771875003037 active site 771875003038 dimer interface [polypeptide binding]; other site 771875003039 motif 1; other site 771875003040 motif 2; other site 771875003041 motif 3; other site 771875003042 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 771875003043 anticodon binding site; other site 771875003044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875003045 Zn2+ binding site [ion binding]; other site 771875003046 Mg2+ binding site [ion binding]; other site 771875003047 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 771875003048 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 771875003049 active site 771875003050 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 771875003051 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 771875003052 Part of AAA domain; Region: AAA_19; pfam13245 771875003053 Family description; Region: UvrD_C_2; pfam13538 771875003054 Uncharacterized conserved protein [Function unknown]; Region: COG1801 771875003055 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 771875003056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 771875003057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 771875003058 DNA binding residues [nucleotide binding] 771875003059 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 771875003060 S-layer homology domain; Region: SLH; pfam00395 771875003061 Vitamin-D-receptor interacting Mediator subunit 4; Region: Med4; pfam10018 771875003062 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 771875003063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 771875003064 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 771875003065 Walker A/P-loop; other site 771875003066 ATP binding site [chemical binding]; other site 771875003067 Q-loop/lid; other site 771875003068 ABC transporter signature motif; other site 771875003069 Walker B; other site 771875003070 D-loop; other site 771875003071 H-loop/switch region; other site 771875003072 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 771875003073 ABC-2 type transporter; Region: ABC2_membrane; cl17235 771875003074 PLD-like domain; Region: PLDc_2; pfam13091 771875003075 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 771875003076 putative active site [active] 771875003077 catalytic site [active] 771875003078 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 771875003079 PLD-like domain; Region: PLDc_2; pfam13091 771875003080 putative active site [active] 771875003081 catalytic site [active] 771875003082 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 771875003083 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 771875003084 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 771875003085 active site 771875003086 HslU subunit interaction site [polypeptide binding]; other site 771875003087 Protein of unknown function (DUF503); Region: DUF503; pfam04456 771875003088 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 771875003089 ornithine carbamoyltransferase; Validated; Region: PRK02102 771875003090 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 771875003091 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 771875003092 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 771875003093 active site 771875003094 nucleotide-binding site [chemical binding]; other site 771875003095 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 771875003096 dimerization interface [polypeptide binding]; other site 771875003097 active site 771875003098 metal binding site [ion binding]; metal-binding site 771875003099 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 771875003100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 771875003101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 771875003102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875003103 Predicted dehydrogenase [General function prediction only]; Region: COG0579 771875003104 hydroxyglutarate oxidase; Provisional; Region: PRK11728 771875003105 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 771875003106 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 771875003107 thymidylate kinase; Validated; Region: tmk; PRK00698 771875003108 TMP-binding site; other site 771875003109 ATP-binding site [chemical binding]; other site 771875003110 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 771875003111 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 771875003112 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 771875003113 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 771875003114 substrate binding pocket [chemical binding]; other site 771875003115 dimer interface [polypeptide binding]; other site 771875003116 inhibitor binding site; inhibition site 771875003117 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 771875003118 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 771875003119 B12 binding site [chemical binding]; other site 771875003120 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 771875003121 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 771875003122 HSP70 interaction site [polypeptide binding]; other site 771875003123 alanine-tRNA ligase; Region: PLN02961 771875003124 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 771875003125 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 771875003126 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 771875003127 HIGH motif; other site 771875003128 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 771875003129 active site 771875003130 KMSKS motif; other site 771875003131 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 771875003132 Uncharacterized conserved protein [Function unknown]; Region: COG3379 771875003133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875003134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003135 dimer interface [polypeptide binding]; other site 771875003136 conserved gate region; other site 771875003137 putative PBP binding loops; other site 771875003138 ABC-ATPase subunit interface; other site 771875003139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 771875003140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003141 dimer interface [polypeptide binding]; other site 771875003142 conserved gate region; other site 771875003143 putative PBP binding loops; other site 771875003144 ABC-ATPase subunit interface; other site 771875003145 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 771875003146 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875003147 Predicted GTPase [General function prediction only]; Region: COG2403 771875003148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 771875003149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 771875003150 dimer interface [polypeptide binding]; other site 771875003151 phosphorylation site [posttranslational modification] 771875003152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875003153 ATP binding site [chemical binding]; other site 771875003154 Mg2+ binding site [ion binding]; other site 771875003155 G-X-G motif; other site 771875003156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 771875003157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875003158 active site 771875003159 phosphorylation site [posttranslational modification] 771875003160 intermolecular recognition site; other site 771875003161 dimerization interface [polypeptide binding]; other site 771875003162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 771875003163 DNA binding site [nucleotide binding] 771875003164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003165 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 771875003166 FeS/SAM binding site; other site 771875003167 Yqey-like protein; Region: YqeY; pfam09424 771875003168 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 771875003169 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 771875003170 active site 771875003171 Zn binding site [ion binding]; other site 771875003172 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 771875003173 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 771875003174 anti sigma factor interaction site; other site 771875003175 regulatory phosphorylation site [posttranslational modification]; other site 771875003176 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 771875003177 anti sigma factor interaction site; other site 771875003178 regulatory phosphorylation site [posttranslational modification]; other site 771875003179 LexA repressor; Validated; Region: PRK00215 771875003180 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 771875003181 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 771875003182 Catalytic site [active] 771875003183 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 771875003184 DNA gyrase subunit A; Validated; Region: PRK05560 771875003185 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 771875003186 CAP-like domain; other site 771875003187 active site 771875003188 primary dimer interface [polypeptide binding]; other site 771875003189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 771875003190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 771875003191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 771875003192 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 771875003193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 771875003194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 771875003195 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 771875003196 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 771875003197 active site 771875003198 HIGH motif; other site 771875003199 KMSKS motif; other site 771875003200 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 771875003201 tRNA binding surface [nucleotide binding]; other site 771875003202 anticodon binding site; other site 771875003203 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 771875003204 dimer interface [polypeptide binding]; other site 771875003205 putative tRNA-binding site [nucleotide binding]; other site 771875003206 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 771875003207 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 771875003208 active site 771875003209 metal binding site [ion binding]; metal-binding site 771875003210 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 771875003211 thymidine kinase; Provisional; Region: PRK04296 771875003212 AAA domain; Region: AAA_14; pfam13173 771875003213 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 771875003214 active site 771875003215 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 771875003216 RuvA N terminal domain; Region: RuvA_N; pfam01330 771875003217 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875003218 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 771875003219 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 771875003220 DRTGG domain; Region: DRTGG; pfam07085 771875003221 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 771875003222 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 771875003223 active site 771875003224 PHP-associated; Region: PHP_C; pfam13263 771875003225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875003226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 771875003227 ATP binding site [chemical binding]; other site 771875003228 Mg2+ binding site [ion binding]; other site 771875003229 G-X-G motif; other site 771875003230 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 771875003231 Surface antigen; Region: Bac_surface_Ag; pfam01103 771875003232 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 771875003233 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 771875003234 minor groove reading motif; other site 771875003235 helix-hairpin-helix signature motif; other site 771875003236 substrate binding pocket [chemical binding]; other site 771875003237 active site 771875003238 glutamate formiminotransferase; Region: FtcD; TIGR02024 771875003239 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 771875003240 Formiminotransferase domain; Region: FTCD; pfam02971 771875003241 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 771875003242 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 771875003243 active site 771875003244 catalytic tetrad [active] 771875003245 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 771875003246 active site 771875003247 catalytic site [active] 771875003248 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 771875003249 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 771875003250 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 771875003251 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 771875003252 putative active site cavity [active] 771875003253 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 771875003254 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 771875003255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875003256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875003257 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 771875003258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875003259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003260 dimer interface [polypeptide binding]; other site 771875003261 conserved gate region; other site 771875003262 putative PBP binding loops; other site 771875003263 ABC-ATPase subunit interface; other site 771875003264 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 771875003265 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 771875003266 putative ligand binding site [chemical binding]; other site 771875003267 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 771875003268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 771875003269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 771875003270 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 771875003271 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 771875003272 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 771875003273 putative active site [active] 771875003274 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 771875003275 dimer interface [polypeptide binding]; other site 771875003276 active site 771875003277 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 771875003278 dimer interface [polypeptide binding]; other site 771875003279 active site 771875003280 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 771875003281 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 771875003282 active site 771875003283 dimer interface [polypeptide binding]; other site 771875003284 MoxR-like ATPases [General function prediction only]; Region: COG0714 771875003285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875003286 Walker A motif; other site 771875003287 ATP binding site [chemical binding]; other site 771875003288 Walker B motif; other site 771875003289 arginine finger; other site 771875003290 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 771875003291 Protein of unknown function DUF58; Region: DUF58; pfam01882 771875003292 FOG: WD40 repeat [General function prediction only]; Region: COG2319 771875003293 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 771875003294 structural tetrad; other site 771875003295 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875003296 Trp docking motif [polypeptide binding]; other site 771875003297 active site 771875003298 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 771875003299 structural tetrad; other site 771875003300 FOG: WD40 repeat [General function prediction only]; Region: COG2319 771875003301 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 771875003302 dimer interface [polypeptide binding]; other site 771875003303 ADP-ribose binding site [chemical binding]; other site 771875003304 active site 771875003305 nudix motif; other site 771875003306 metal binding site [ion binding]; metal-binding site 771875003307 Flagellar protein FliS; Region: FliS; cl00654 771875003308 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 771875003309 putative CheA interaction surface; other site 771875003310 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 771875003311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 771875003312 RNA binding surface [nucleotide binding]; other site 771875003313 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 771875003314 active site 771875003315 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 771875003316 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 771875003317 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 771875003318 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 771875003319 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 771875003320 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 771875003321 GTP/Mg2+ binding site [chemical binding]; other site 771875003322 G4 box; other site 771875003323 G1 box; other site 771875003324 Switch I region; other site 771875003325 G2 box; other site 771875003326 G3 box; other site 771875003327 Switch II region; other site 771875003328 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 771875003329 putative nucleotide binding site [chemical binding]; other site 771875003330 uridine monophosphate binding site [chemical binding]; other site 771875003331 homohexameric interface [polypeptide binding]; other site 771875003332 AAA domain; Region: AAA_23; pfam13476 771875003333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875003334 Walker A/P-loop; other site 771875003335 ATP binding site [chemical binding]; other site 771875003336 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 771875003337 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 771875003338 putative active site [active] 771875003339 PhoH-like protein; Region: PhoH; pfam02562 771875003340 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 771875003341 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 771875003342 active site 771875003343 catalytic site [active] 771875003344 substrate binding site [chemical binding]; other site 771875003345 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 771875003346 MgtE intracellular N domain; Region: MgtE_N; smart00924 771875003347 FliG C-terminal domain; Region: FliG_C; pfam01706 771875003348 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 771875003349 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 771875003350 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 771875003351 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 771875003352 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 771875003353 putative phosphate acyltransferase; Provisional; Region: PRK05331 771875003354 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 771875003355 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 771875003356 glutaminase active site [active] 771875003357 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 771875003358 dimer interface [polypeptide binding]; other site 771875003359 active site 771875003360 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 771875003361 dimer interface [polypeptide binding]; other site 771875003362 active site 771875003363 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 771875003364 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 771875003365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875003366 Walker A motif; other site 771875003367 ATP binding site [chemical binding]; other site 771875003368 Walker B motif; other site 771875003369 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 771875003370 UGMP family protein; Validated; Region: PRK09604 771875003371 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 771875003372 Rod binding protein; Region: Rod-binding; pfam10135 771875003373 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 771875003374 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 771875003375 Flagellar L-ring protein; Region: FlgH; cl17277 771875003376 SAF-like; Region: SAF_2; pfam13144 771875003377 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 771875003378 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 771875003379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 771875003380 active site 771875003381 membrane protein; Provisional; Region: PRK14404 771875003382 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 771875003383 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 771875003384 [2Fe-2S] cluster binding site [ion binding]; other site 771875003385 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 771875003386 hydrophobic ligand binding site; other site 771875003387 SnoaL-like domain; Region: SnoaL_2; pfam12680 771875003388 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 771875003389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 771875003390 NAD(P) binding site [chemical binding]; other site 771875003391 active site 771875003392 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 771875003393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 771875003394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 771875003395 Integrase core domain; Region: rve; pfam00665 771875003396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875003397 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 771875003398 Walker A motif; other site 771875003399 ATP binding site [chemical binding]; other site 771875003400 Walker B motif; other site 771875003401 arginine finger; other site 771875003402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 771875003403 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 771875003404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875003405 Walker A/P-loop; other site 771875003406 ATP binding site [chemical binding]; other site 771875003407 Q-loop/lid; other site 771875003408 ABC transporter signature motif; other site 771875003409 Walker B; other site 771875003410 D-loop; other site 771875003411 H-loop/switch region; other site 771875003412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 771875003413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 771875003414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875003415 Walker A/P-loop; other site 771875003416 ATP binding site [chemical binding]; other site 771875003417 Q-loop/lid; other site 771875003418 ABC transporter signature motif; other site 771875003419 Walker B; other site 771875003420 D-loop; other site 771875003421 H-loop/switch region; other site 771875003422 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 771875003423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875003424 ATP binding site [chemical binding]; other site 771875003425 Mg2+ binding site [ion binding]; other site 771875003426 G-X-G motif; other site 771875003427 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 771875003428 anchoring element; other site 771875003429 dimer interface [polypeptide binding]; other site 771875003430 ATP binding site [chemical binding]; other site 771875003431 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 771875003432 active site 771875003433 putative metal-binding site [ion binding]; other site 771875003434 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 771875003435 Protein of unknown function (DUF721); Region: DUF721; pfam05258 771875003436 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 771875003437 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 771875003438 homodimer interface [polypeptide binding]; other site 771875003439 substrate-cofactor binding pocket; other site 771875003440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875003441 catalytic residue [active] 771875003442 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 771875003443 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 771875003444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003445 FeS/SAM binding site; other site 771875003446 FOG: CBS domain [General function prediction only]; Region: COG0517 771875003447 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 771875003448 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 771875003449 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 771875003450 putative substrate binding site [chemical binding]; other site 771875003451 putative ATP binding site [chemical binding]; other site 771875003452 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 771875003453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875003454 Walker A/P-loop; other site 771875003455 ATP binding site [chemical binding]; other site 771875003456 Q-loop/lid; other site 771875003457 aspartate aminotransferase; Provisional; Region: PRK05764 771875003458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 771875003459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875003460 homodimer interface [polypeptide binding]; other site 771875003461 catalytic residue [active] 771875003462 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 771875003463 tetramer interface [polypeptide binding]; other site 771875003464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875003465 catalytic residue [active] 771875003466 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 771875003467 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 771875003468 tetramer interface [polypeptide binding]; other site 771875003469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875003470 catalytic residue [active] 771875003471 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 771875003472 POPLD (NUC188) domain; Region: POPLD; pfam08170 771875003473 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 771875003474 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 771875003475 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 771875003476 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 771875003477 active site 771875003478 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 771875003479 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 771875003480 B12 binding site [chemical binding]; other site 771875003481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003482 FeS/SAM binding site; other site 771875003483 Rhomboid family; Region: Rhomboid; pfam01694 771875003484 hypothetical protein; Provisional; Region: PRK14628 771875003485 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 771875003486 ApbE family; Region: ApbE; pfam02424 771875003487 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 771875003488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003489 FeS/SAM binding site; other site 771875003490 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 771875003491 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 771875003492 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 771875003493 substrate binding site [chemical binding]; other site 771875003494 hexamer interface [polypeptide binding]; other site 771875003495 metal binding site [ion binding]; metal-binding site 771875003496 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 771875003497 PhoH-like protein; Region: PhoH; pfam02562 771875003498 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 771875003499 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875003500 Zn2+ binding site [ion binding]; other site 771875003501 Mg2+ binding site [ion binding]; other site 771875003502 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 771875003503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 771875003504 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 771875003505 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 771875003506 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 771875003507 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 771875003508 substrate binding site; other site 771875003509 tetramer interface; other site 771875003510 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 771875003511 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 771875003512 inhibitor-cofactor binding pocket; inhibition site 771875003513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875003514 catalytic residue [active] 771875003515 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 771875003516 trimer interface [polypeptide binding]; other site 771875003517 active site 771875003518 substrate binding site [chemical binding]; other site 771875003519 CoA binding site [chemical binding]; other site 771875003520 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 771875003521 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 771875003522 NAD binding site [chemical binding]; other site 771875003523 substrate binding site [chemical binding]; other site 771875003524 homodimer interface [polypeptide binding]; other site 771875003525 active site 771875003526 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 771875003527 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 771875003528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875003529 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 771875003530 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 771875003531 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 771875003532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003533 dimer interface [polypeptide binding]; other site 771875003534 conserved gate region; other site 771875003535 putative PBP binding loops; other site 771875003536 ABC-ATPase subunit interface; other site 771875003537 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 771875003538 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 771875003539 Walker A/P-loop; other site 771875003540 ATP binding site [chemical binding]; other site 771875003541 Q-loop/lid; other site 771875003542 ABC transporter signature motif; other site 771875003543 Walker B; other site 771875003544 D-loop; other site 771875003545 H-loop/switch region; other site 771875003546 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 771875003547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003548 dimer interface [polypeptide binding]; other site 771875003549 conserved gate region; other site 771875003550 ABC-ATPase subunit interface; other site 771875003551 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875003552 dimer interface [polypeptide binding]; other site 771875003553 [2Fe-2S] cluster binding site [ion binding]; other site 771875003554 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 771875003555 SLBB domain; Region: SLBB; pfam10531 771875003556 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 771875003557 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 771875003558 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 771875003559 putative dimer interface [polypeptide binding]; other site 771875003560 [2Fe-2S] cluster binding site [ion binding]; other site 771875003561 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875003562 dimer interface [polypeptide binding]; other site 771875003563 [2Fe-2S] cluster binding site [ion binding]; other site 771875003564 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 771875003565 SLBB domain; Region: SLBB; pfam10531 771875003566 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 771875003567 4Fe-4S binding domain; Region: Fer4; pfam00037 771875003568 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 771875003569 4Fe-4S binding domain; Region: Fer4; pfam00037 771875003570 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875003571 dimer interface [polypeptide binding]; other site 771875003572 [2Fe-2S] cluster binding site [ion binding]; other site 771875003573 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 771875003574 dimer interface [polypeptide binding]; other site 771875003575 [2Fe-2S] cluster binding site [ion binding]; other site 771875003576 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 771875003577 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 771875003578 putative dimer interface [polypeptide binding]; other site 771875003579 [2Fe-2S] cluster binding site [ion binding]; other site 771875003580 EamA-like transporter family; Region: EamA; pfam00892 771875003581 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 771875003582 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 771875003583 putative substrate binding pocket [chemical binding]; other site 771875003584 AC domain interface; other site 771875003585 catalytic triad [active] 771875003586 AB domain interface; other site 771875003587 interchain disulfide; other site 771875003588 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 771875003589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 771875003590 active site 771875003591 phosphorylation site [posttranslational modification] 771875003592 dimerization interface [polypeptide binding]; other site 771875003593 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 771875003594 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 771875003595 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 771875003596 NAD(P) binding site [chemical binding]; other site 771875003597 LDH/MDH dimer interface [polypeptide binding]; other site 771875003598 substrate binding site [chemical binding]; other site 771875003599 Transposase domain (DUF772); Region: DUF772; pfam05598 771875003600 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 771875003601 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 771875003602 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 771875003603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875003604 Walker A/P-loop; other site 771875003605 ATP binding site [chemical binding]; other site 771875003606 Q-loop/lid; other site 771875003607 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 771875003608 ABC transporter signature motif; other site 771875003609 Walker B; other site 771875003610 D-loop; other site 771875003611 H-loop/switch region; other site 771875003612 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 771875003613 active site 771875003614 catalytic motif [active] 771875003615 Zn binding site [ion binding]; other site 771875003616 Domain of unknown function DUF21; Region: DUF21; pfam01595 771875003617 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 771875003618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 771875003619 Transporter associated domain; Region: CorC_HlyC; smart01091 771875003620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875003621 PAS domain; Region: PAS_9; pfam13426 771875003622 putative active site [active] 771875003623 heme pocket [chemical binding]; other site 771875003624 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875003625 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875003626 metal binding site [ion binding]; metal-binding site 771875003627 active site 771875003628 I-site; other site 771875003629 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 771875003630 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 771875003631 active site 771875003632 NAD binding site [chemical binding]; other site 771875003633 metal binding site [ion binding]; metal-binding site 771875003634 S-layer homology domain; Region: SLH; pfam00395 771875003635 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 771875003636 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 771875003637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875003638 active site 771875003639 phosphorylation site [posttranslational modification] 771875003640 intermolecular recognition site; other site 771875003641 dimerization interface [polypeptide binding]; other site 771875003642 CheB methylesterase; Region: CheB_methylest; pfam01339 771875003643 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 771875003644 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 771875003645 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 771875003646 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 771875003647 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 771875003648 TPP-binding site [chemical binding]; other site 771875003649 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 771875003650 catalytic motif [active] 771875003651 Zn binding site [ion binding]; other site 771875003652 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 771875003653 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 771875003654 DNA binding site [nucleotide binding] 771875003655 active site 771875003656 Transglycosylase; Region: Transgly; pfam00912 771875003657 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 771875003658 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 771875003659 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 771875003660 active site 771875003661 multimer interface [polypeptide binding]; other site 771875003662 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 771875003663 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 771875003664 diiron binding motif [ion binding]; other site 771875003665 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 771875003666 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 771875003667 putative active site [active] 771875003668 putative metal binding site [ion binding]; other site 771875003669 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 771875003670 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 771875003671 DNA-binding site [nucleotide binding]; DNA binding site 771875003672 RNA-binding motif; other site 771875003673 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 771875003674 DNA-binding site [nucleotide binding]; DNA binding site 771875003675 RNA-binding motif; other site 771875003676 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 771875003677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 771875003678 RNA binding surface [nucleotide binding]; other site 771875003679 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 771875003680 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 771875003681 GAF domain; Region: GAF; cl17456 771875003682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875003683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875003684 metal binding site [ion binding]; metal-binding site 771875003685 active site 771875003686 I-site; other site 771875003687 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 771875003688 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 771875003689 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 771875003690 Walker A/P-loop; other site 771875003691 ATP binding site [chemical binding]; other site 771875003692 Q-loop/lid; other site 771875003693 ABC transporter signature motif; other site 771875003694 Walker B; other site 771875003695 D-loop; other site 771875003696 H-loop/switch region; other site 771875003697 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 771875003698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003699 FeS/SAM binding site; other site 771875003700 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 771875003701 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 771875003702 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 771875003703 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 771875003704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 771875003705 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 771875003706 FAD binding site [chemical binding]; other site 771875003707 homotetramer interface [polypeptide binding]; other site 771875003708 substrate binding pocket [chemical binding]; other site 771875003709 catalytic base [active] 771875003710 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 771875003711 Ligand binding site [chemical binding]; other site 771875003712 Electron transfer flavoprotein domain; Region: ETF; pfam01012 771875003713 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 771875003714 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 771875003715 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 771875003716 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 771875003717 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 771875003718 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 771875003719 putative N- and C-terminal domain interface [polypeptide binding]; other site 771875003720 putative active site [active] 771875003721 MgATP binding site [chemical binding]; other site 771875003722 catalytic site [active] 771875003723 metal binding site [ion binding]; metal-binding site 771875003724 putative carbohydrate binding site [chemical binding]; other site 771875003725 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 771875003726 active site 771875003727 catalytic triad [active] 771875003728 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 771875003729 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 771875003730 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 771875003731 active site 771875003732 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 771875003733 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 771875003734 putative active site [active] 771875003735 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 771875003736 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 771875003737 mRNA/rRNA interface [nucleotide binding]; other site 771875003738 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 771875003739 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 771875003740 23S rRNA interface [nucleotide binding]; other site 771875003741 L7/L12 interface [polypeptide binding]; other site 771875003742 putative thiostrepton binding site; other site 771875003743 L25 interface [polypeptide binding]; other site 771875003744 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 771875003745 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 771875003746 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 771875003747 putative homodimer interface [polypeptide binding]; other site 771875003748 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 771875003749 heterodimer interface [polypeptide binding]; other site 771875003750 homodimer interface [polypeptide binding]; other site 771875003751 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 771875003752 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 771875003753 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 771875003754 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 771875003755 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 771875003756 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 771875003757 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 771875003758 catalytic residues [active] 771875003759 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 771875003760 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 771875003761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 771875003762 Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO)-like family, N-terminal TRX-fold subdomain; composed of proteins with similarity to PfPDO, a redox active thermostable protein believed to be the archaeal counterpart of bacterial DsbA and...; Region: PfPDO_like_N; cd02975 771875003763 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 771875003764 catalytic residues [active] 771875003765 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 771875003766 catalytic residues [active] 771875003767 Esterase/lipase [General function prediction only]; Region: COG1647 771875003768 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 771875003769 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 771875003770 nucleophilic elbow; other site 771875003771 catalytic triad; other site 771875003772 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 771875003773 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 771875003774 ABC-ATPase subunit interface; other site 771875003775 dimer interface [polypeptide binding]; other site 771875003776 putative PBP binding regions; other site 771875003777 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 771875003778 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 771875003779 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 771875003780 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 771875003781 intersubunit interface [polypeptide binding]; other site 771875003782 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 771875003783 metal binding site 2 [ion binding]; metal-binding site 771875003784 putative DNA binding helix; other site 771875003785 metal binding site 1 [ion binding]; metal-binding site 771875003786 dimer interface [polypeptide binding]; other site 771875003787 structural Zn2+ binding site [ion binding]; other site 771875003788 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 771875003789 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 771875003790 active site 771875003791 catalytic tetrad [active] 771875003792 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 771875003793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003794 FeS/SAM binding site; other site 771875003795 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 771875003796 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 771875003797 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 771875003798 Cl- selectivity filter; other site 771875003799 Cl- binding residues [ion binding]; other site 771875003800 pore gating glutamate residue; other site 771875003801 dimer interface [polypeptide binding]; other site 771875003802 H+/Cl- coupling transport residue; other site 771875003803 TrkA-C domain; Region: TrkA_C; pfam02080 771875003804 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 771875003805 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 771875003806 TPP-binding site [chemical binding]; other site 771875003807 putative dimer interface [polypeptide binding]; other site 771875003808 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 771875003809 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 771875003810 dimer interface [polypeptide binding]; other site 771875003811 PYR/PP interface [polypeptide binding]; other site 771875003812 TPP binding site [chemical binding]; other site 771875003813 substrate binding site [chemical binding]; other site 771875003814 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 771875003815 4Fe-4S binding domain; Region: Fer4; cl02805 771875003816 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 771875003817 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 771875003818 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 771875003819 Uncharacterized conserved protein [Function unknown]; Region: COG1543 771875003820 active site 771875003821 substrate binding site [chemical binding]; other site 771875003822 catalytic site [active] 771875003823 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 771875003824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 771875003825 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 771875003826 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 771875003827 Walker A/P-loop; other site 771875003828 ATP binding site [chemical binding]; other site 771875003829 Q-loop/lid; other site 771875003830 ABC transporter signature motif; other site 771875003831 Walker B; other site 771875003832 D-loop; other site 771875003833 H-loop/switch region; other site 771875003834 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 771875003835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003836 dimer interface [polypeptide binding]; other site 771875003837 conserved gate region; other site 771875003838 putative PBP binding loops; other site 771875003839 ABC-ATPase subunit interface; other site 771875003840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 771875003841 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 771875003842 substrate binding pocket [chemical binding]; other site 771875003843 membrane-bound complex binding site; other site 771875003844 hinge residues; other site 771875003845 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 771875003846 DALR anticodon binding domain; Region: DALR_1; pfam05746 771875003847 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 771875003848 dimer interface [polypeptide binding]; other site 771875003849 motif 1; other site 771875003850 active site 771875003851 motif 2; other site 771875003852 motif 3; other site 771875003853 Predicted permeases [General function prediction only]; Region: COG0679 771875003854 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 771875003855 NlpC/P60 family; Region: NLPC_P60; pfam00877 771875003856 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875003857 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875003858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003859 dimer interface [polypeptide binding]; other site 771875003860 conserved gate region; other site 771875003861 ABC-ATPase subunit interface; other site 771875003862 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003864 dimer interface [polypeptide binding]; other site 771875003865 conserved gate region; other site 771875003866 putative PBP binding loops; other site 771875003867 ABC-ATPase subunit interface; other site 771875003868 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 771875003869 PGAP1-like protein; Region: PGAP1; pfam07819 771875003870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 771875003871 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 771875003872 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 771875003873 Family description; Region: VCBS; pfam13517 771875003874 Family description; Region: VCBS; pfam13517 771875003875 Family description; Region: VCBS; pfam13517 771875003876 Family description; Region: VCBS; pfam13517 771875003877 Family description; Region: VCBS; pfam13517 771875003878 dipeptidase PepV; Reviewed; Region: PRK07318 771875003879 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 771875003880 active site 771875003881 metal binding site [ion binding]; metal-binding site 771875003882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875003883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875003884 DNA binding site [nucleotide binding] 771875003885 domain linker motif; other site 771875003886 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875003887 dimerization interface [polypeptide binding]; other site 771875003888 ligand binding site [chemical binding]; other site 771875003889 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 771875003890 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 771875003891 hexamer (dimer of trimers) interface [polypeptide binding]; other site 771875003892 substrate binding site [chemical binding]; other site 771875003893 trimer interface [polypeptide binding]; other site 771875003894 Mn binding site [ion binding]; other site 771875003895 alpha-glucosidase; Provisional; Region: PRK10426 771875003896 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 771875003897 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 771875003898 putative active site [active] 771875003899 putative catalytic site [active] 771875003900 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 771875003901 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 771875003902 PYR/PP interface [polypeptide binding]; other site 771875003903 dimer interface [polypeptide binding]; other site 771875003904 TPP binding site [chemical binding]; other site 771875003905 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 771875003906 transketolase; Reviewed; Region: PRK05899 771875003907 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 771875003908 TPP-binding site [chemical binding]; other site 771875003909 dimer interface [polypeptide binding]; other site 771875003910 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 771875003911 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 771875003912 putative active site [active] 771875003913 metal binding site [ion binding]; metal-binding site 771875003914 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 771875003915 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 771875003916 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003918 dimer interface [polypeptide binding]; other site 771875003919 conserved gate region; other site 771875003920 putative PBP binding loops; other site 771875003921 ABC-ATPase subunit interface; other site 771875003922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 771875003923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875003924 putative PBP binding loops; other site 771875003925 ABC-ATPase subunit interface; other site 771875003926 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875003927 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875003928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875003929 Coenzyme A binding pocket [chemical binding]; other site 771875003930 hypothetical protein; Provisional; Region: PRK10621 771875003931 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 771875003932 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434 771875003933 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 771875003934 Ribonuclease P; Region: Ribonuclease_P; pfam00825 771875003935 Haemolytic domain; Region: Haemolytic; pfam01809 771875003936 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 771875003937 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 771875003938 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 771875003939 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 771875003940 G-X-X-G motif; other site 771875003941 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 771875003942 RxxxH motif; other site 771875003943 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 771875003944 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 771875003945 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 771875003946 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 771875003947 putative ligand binding site [chemical binding]; other site 771875003948 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 771875003949 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 771875003950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875003951 catalytic residue [active] 771875003952 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 771875003953 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 771875003954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875003955 FeS/SAM binding site; other site 771875003956 Domain of unknown function (DUF370); Region: DUF370; cl00898 771875003957 GTP-binding protein YchF; Reviewed; Region: PRK09601 771875003958 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 771875003959 G1 box; other site 771875003960 GTP/Mg2+ binding site [chemical binding]; other site 771875003961 G2 box; other site 771875003962 Switch I region; other site 771875003963 G3 box; other site 771875003964 Switch II region; other site 771875003965 G4 box; other site 771875003966 G5 box; other site 771875003967 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 771875003968 tRNA pseudouridine synthase B; Provisional; Region: PRK14124 771875003969 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 771875003970 RNA binding site [nucleotide binding]; other site 771875003971 active site 771875003972 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 771875003973 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 771875003974 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 771875003975 dimer interface [polypeptide binding]; other site 771875003976 motif 1; other site 771875003977 active site 771875003978 motif 2; other site 771875003979 motif 3; other site 771875003980 Domain of unknown function (DUF368); Region: DUF368; pfam04018 771875003981 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875003982 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 771875003983 active site 771875003984 metal binding site [ion binding]; metal-binding site 771875003985 DNA topoisomerase I; Validated; Region: PRK06599 771875003986 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 771875003987 active site 771875003988 interdomain interaction site; other site 771875003989 putative metal-binding site [ion binding]; other site 771875003990 nucleotide binding site [chemical binding]; other site 771875003991 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 771875003992 domain I; other site 771875003993 DNA binding groove [nucleotide binding] 771875003994 phosphate binding site [ion binding]; other site 771875003995 domain II; other site 771875003996 domain III; other site 771875003997 nucleotide binding site [chemical binding]; other site 771875003998 catalytic site [active] 771875003999 domain IV; other site 771875004000 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 771875004001 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 771875004002 generic binding surface II; other site 771875004003 generic binding surface I; other site 771875004004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875004005 Zn2+ binding site [ion binding]; other site 771875004006 Mg2+ binding site [ion binding]; other site 771875004007 alanine racemase; Reviewed; Region: alr; PRK00053 771875004008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 771875004009 active site 771875004010 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 771875004011 dimer interface [polypeptide binding]; other site 771875004012 substrate binding site [chemical binding]; other site 771875004013 catalytic residues [active] 771875004014 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 771875004015 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 771875004016 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 771875004017 domain interfaces; other site 771875004018 active site 771875004019 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 771875004020 lipoyl attachment site [posttranslational modification]; other site 771875004021 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875004022 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875004023 Integrase core domain; Region: rve; pfam00665 771875004024 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 771875004025 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 771875004026 generic binding surface II; other site 771875004027 ssDNA binding site; other site 771875004028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 771875004029 ATP binding site [chemical binding]; other site 771875004030 putative Mg++ binding site [ion binding]; other site 771875004031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 771875004032 nucleotide binding region [chemical binding]; other site 771875004033 ATP-binding site [chemical binding]; other site 771875004034 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 771875004035 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 771875004036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 771875004037 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 771875004038 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 771875004039 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 771875004040 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 771875004041 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 771875004042 homodimer interface [polypeptide binding]; other site 771875004043 metal binding site [ion binding]; metal-binding site 771875004044 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 771875004045 homodimer interface [polypeptide binding]; other site 771875004046 active site 771875004047 putative chemical substrate binding site [chemical binding]; other site 771875004048 metal binding site [ion binding]; metal-binding site 771875004049 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 771875004050 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 771875004051 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 771875004052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875004053 S-adenosylmethionine binding site [chemical binding]; other site 771875004054 Uncharacterized conserved protein [Function unknown]; Region: COG0062 771875004055 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 771875004056 putative substrate binding site [chemical binding]; other site 771875004057 putative ATP binding site [chemical binding]; other site 771875004058 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 771875004059 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 771875004060 N-acetyl-D-glucosamine binding site [chemical binding]; other site 771875004061 catalytic residue [active] 771875004062 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 771875004063 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 771875004064 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 771875004065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875004066 binding surface 771875004067 TPR motif; other site 771875004068 TPR repeat; Region: TPR_11; pfam13414 771875004069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875004070 binding surface 771875004071 Tetratricopeptide repeat; Region: TPR_16; pfam13432 771875004072 TPR motif; other site 771875004073 Tetratricopeptide repeat; Region: TPR_16; pfam13432 771875004074 Tetratricopeptide repeat; Region: TPR_16; pfam13432 771875004075 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 771875004076 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 771875004077 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 771875004078 protein binding site [polypeptide binding]; other site 771875004079 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 771875004080 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 771875004081 Ligand Binding Site [chemical binding]; other site 771875004082 TIGR00269 family protein; Region: TIGR00269 771875004083 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 771875004084 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 771875004085 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 771875004086 active site 771875004087 substrate binding site [chemical binding]; other site 771875004088 metal binding site [ion binding]; metal-binding site 771875004089 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 771875004090 active site 771875004091 catalytic residues [active] 771875004092 metal binding site [ion binding]; metal-binding site 771875004093 stationary phase survival protein SurE; Provisional; Region: PRK13935 771875004094 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 771875004095 GcpE protein; Region: GcpE; pfam04551 771875004096 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 771875004097 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 771875004098 active site 771875004099 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 771875004100 protein binding site [polypeptide binding]; other site 771875004101 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 771875004102 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 771875004103 putative substrate binding region [chemical binding]; other site 771875004104 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 771875004105 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 771875004106 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 771875004107 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 771875004108 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 771875004109 Thiamine pyrophosphokinase; Region: TPK; cd07995 771875004110 active site 771875004111 dimerization interface [polypeptide binding]; other site 771875004112 thiamine binding site [chemical binding]; other site 771875004113 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 771875004114 putative hydrophobic ligand binding site [chemical binding]; other site 771875004115 endonuclease IV; Provisional; Region: PRK01060 771875004116 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 771875004117 AP (apurinic/apyrimidinic) site pocket; other site 771875004118 DNA interaction; other site 771875004119 Metal-binding active site; metal-binding site 771875004120 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 771875004121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875004122 Coenzyme A binding pocket [chemical binding]; other site 771875004123 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 771875004124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 771875004125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 771875004126 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 771875004127 EamA-like transporter family; Region: EamA; pfam00892 771875004128 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 771875004129 putative FMN binding site [chemical binding]; other site 771875004130 NADPH bind site [chemical binding]; other site 771875004131 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 771875004132 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 771875004133 putative tRNA-binding site [nucleotide binding]; other site 771875004134 B3/4 domain; Region: B3_4; pfam03483 771875004135 tRNA synthetase B5 domain; Region: B5; smart00874 771875004136 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 771875004137 dimer interface [polypeptide binding]; other site 771875004138 motif 1; other site 771875004139 motif 3; other site 771875004140 motif 2; other site 771875004141 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 771875004142 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 771875004143 Bifunctional nuclease; Region: DNase-RNase; pfam02577 771875004144 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 771875004145 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 771875004146 putative acyl-acceptor binding pocket; other site 771875004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875004148 binding surface 771875004149 TPR motif; other site 771875004150 TPR repeat; Region: TPR_11; pfam13414 771875004151 membrane protein; Provisional; Region: PRK14406 771875004152 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 771875004153 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 771875004154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 771875004155 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 771875004156 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 771875004157 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 771875004158 rod shape-determining protein MreB; Provisional; Region: PRK13930 771875004159 MreB and similar proteins; Region: MreB_like; cd10225 771875004160 nucleotide binding site [chemical binding]; other site 771875004161 Mg binding site [ion binding]; other site 771875004162 putative protofilament interaction site [polypeptide binding]; other site 771875004163 RodZ interaction site [polypeptide binding]; other site 771875004164 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 771875004165 EamA-like transporter family; Region: EamA; pfam00892 771875004166 EamA-like transporter family; Region: EamA; pfam00892 771875004167 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 771875004168 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 771875004169 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 771875004170 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 771875004171 putative binding surface; other site 771875004172 active site 771875004173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875004174 ATP binding site [chemical binding]; other site 771875004175 Mg2+ binding site [ion binding]; other site 771875004176 G-X-G motif; other site 771875004177 Response regulator receiver domain; Region: Response_reg; pfam00072 771875004178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875004179 active site 771875004180 phosphorylation site [posttranslational modification] 771875004181 intermolecular recognition site; other site 771875004182 dimerization interface [polypeptide binding]; other site 771875004183 CheB methylesterase; Region: CheB_methylest; pfam01339 771875004184 Response regulator receiver domain; Region: Response_reg; pfam00072 771875004185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875004186 active site 771875004187 phosphorylation site [posttranslational modification] 771875004188 intermolecular recognition site; other site 771875004189 dimerization interface [polypeptide binding]; other site 771875004190 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 771875004191 nucleotidyl binding site; other site 771875004192 metal binding site [ion binding]; metal-binding site 771875004193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875004194 dimer interface [polypeptide binding]; other site 771875004195 putative CheW interface [polypeptide binding]; other site 771875004196 putative DNA binding site [nucleotide binding]; other site 771875004197 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 771875004198 dimerization interface [polypeptide binding]; other site 771875004199 putative Zn2+ binding site [ion binding]; other site 771875004200 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 771875004201 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 771875004202 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875004203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004205 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875004206 Protein of unknown function (DUF342); Region: DUF342; pfam03961 771875004207 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 771875004208 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 771875004209 putative active site [active] 771875004210 substrate binding site [chemical binding]; other site 771875004211 putative cosubstrate binding site; other site 771875004212 catalytic site [active] 771875004213 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 771875004214 substrate binding site [chemical binding]; other site 771875004215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875004216 TPR motif; other site 771875004217 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 771875004218 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 771875004219 substrate binding site [chemical binding]; other site 771875004220 ATP binding site [chemical binding]; other site 771875004221 Peptidase S8 family domain in Fervidolysin; Region: Peptidases_S8_Fervidolysin_like; cd07485 771875004222 active site 771875004223 catalytic triad [active] 771875004224 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 771875004225 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 771875004226 oligomer interface [polypeptide binding]; other site 771875004227 active site 771875004228 metal binding site [ion binding]; metal-binding site 771875004229 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 771875004230 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 771875004231 oligomer interface [polypeptide binding]; other site 771875004232 active site 771875004233 metal binding site [ion binding]; metal-binding site 771875004234 septum formation inhibitor; Provisional; Region: minC; PRK13992 771875004235 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 771875004236 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 771875004237 HD domain; Region: HD_3; cl17350 771875004238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875004239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875004240 metal binding site [ion binding]; metal-binding site 771875004241 active site 771875004242 I-site; other site 771875004243 HAMP domain; Region: HAMP; pfam00672 771875004244 dimerization interface [polypeptide binding]; other site 771875004245 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 771875004246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875004247 dimer interface [polypeptide binding]; other site 771875004248 putative CheW interface [polypeptide binding]; other site 771875004249 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 771875004250 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 771875004251 active site 771875004252 catalytic residues [active] 771875004253 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 771875004254 GAF domain; Region: GAF; cl17456 771875004255 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875004256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875004257 metal binding site [ion binding]; metal-binding site 771875004258 active site 771875004259 I-site; other site 771875004260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 771875004261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 771875004262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875004263 Walker A/P-loop; other site 771875004264 ATP binding site [chemical binding]; other site 771875004265 Q-loop/lid; other site 771875004266 ABC transporter signature motif; other site 771875004267 Walker B; other site 771875004268 D-loop; other site 771875004269 H-loop/switch region; other site 771875004270 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 771875004271 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 771875004272 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 771875004273 NAD(P) binding site [chemical binding]; other site 771875004274 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 771875004275 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 771875004276 Potassium binding sites [ion binding]; other site 771875004277 Cesium cation binding sites [ion binding]; other site 771875004278 ribonuclease III; Reviewed; Region: rnc; PRK00102 771875004279 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 771875004280 dimerization interface [polypeptide binding]; other site 771875004281 active site 771875004282 metal binding site [ion binding]; metal-binding site 771875004283 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 771875004284 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 771875004285 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 771875004286 active site 771875004287 DNA binding site [nucleotide binding] 771875004288 Int/Topo IB signature motif; other site 771875004289 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 771875004290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875004291 Zn2+ binding site [ion binding]; other site 771875004292 Mg2+ binding site [ion binding]; other site 771875004293 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 771875004294 synthetase active site [active] 771875004295 NTP binding site [chemical binding]; other site 771875004296 metal binding site [ion binding]; metal-binding site 771875004297 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 771875004298 ACT domain; Region: ACT_4; pfam13291 771875004299 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 771875004300 putative active site [active] 771875004301 dimerization interface [polypeptide binding]; other site 771875004302 putative tRNAtyr binding site [nucleotide binding]; other site 771875004303 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 771875004304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 771875004305 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 771875004306 Divergent PAP2 family; Region: DUF212; cl00855 771875004307 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 771875004308 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 771875004309 N-acetyl-D-glucosamine binding site [chemical binding]; other site 771875004310 catalytic residue [active] 771875004311 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 771875004312 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 771875004313 Walker A/P-loop; other site 771875004314 ATP binding site [chemical binding]; other site 771875004315 Q-loop/lid; other site 771875004316 ABC transporter signature motif; other site 771875004317 Walker B; other site 771875004318 D-loop; other site 771875004319 H-loop/switch region; other site 771875004320 uracil transporter; Provisional; Region: PRK10720 771875004321 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 771875004322 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 771875004323 NAD binding site [chemical binding]; other site 771875004324 ATP-grasp domain; Region: ATP-grasp; pfam02222 771875004325 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 771875004326 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 771875004327 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 771875004328 ATP binding site [chemical binding]; other site 771875004329 active site 771875004330 substrate binding site [chemical binding]; other site 771875004331 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 771875004332 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 771875004333 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 771875004334 putative active site [active] 771875004335 catalytic triad [active] 771875004336 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK14090 771875004337 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 771875004338 dimerization interface [polypeptide binding]; other site 771875004339 ATP binding site [chemical binding]; other site 771875004340 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 771875004341 dimerization interface [polypeptide binding]; other site 771875004342 ATP binding site [chemical binding]; other site 771875004343 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 771875004344 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 771875004345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 771875004346 active site 771875004347 phosphorylation site [posttranslational modification] 771875004348 intermolecular recognition site; other site 771875004349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875004350 Zn2+ binding site [ion binding]; other site 771875004351 Mg2+ binding site [ion binding]; other site 771875004352 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 771875004353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 771875004354 RNA binding surface [nucleotide binding]; other site 771875004355 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 771875004356 active site 771875004357 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 771875004358 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 771875004359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875004360 S-adenosylmethionine binding site [chemical binding]; other site 771875004361 hypothetical protein; Validated; Region: PRK00110 771875004362 Clp protease; Region: CLP_protease; pfam00574 771875004363 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 771875004364 oligomer interface [polypeptide binding]; other site 771875004365 active site residues [active] 771875004366 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 771875004367 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 771875004368 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 771875004369 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 771875004370 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 771875004371 alphaNTD - beta interaction site [polypeptide binding]; other site 771875004372 alphaNTD homodimer interface [polypeptide binding]; other site 771875004373 alphaNTD - beta' interaction site [polypeptide binding]; other site 771875004374 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 771875004375 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 771875004376 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 771875004377 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 771875004378 RNA binding surface [nucleotide binding]; other site 771875004379 30S ribosomal protein S11; Validated; Region: PRK05309 771875004380 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 771875004381 30S ribosomal protein S13; Region: bact_S13; TIGR03631 771875004382 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 771875004383 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 771875004384 rRNA binding site [nucleotide binding]; other site 771875004385 predicted 30S ribosome binding site; other site 771875004386 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 771875004387 active site 771875004388 adenylate kinase; Reviewed; Region: adk; PRK00279 771875004389 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 771875004390 AMP-binding site [chemical binding]; other site 771875004391 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 771875004392 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 771875004393 SecY translocase; Region: SecY; pfam00344 771875004394 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 771875004395 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 771875004396 23S rRNA binding site [nucleotide binding]; other site 771875004397 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 771875004398 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 771875004399 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 771875004400 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 771875004401 5S rRNA interface [nucleotide binding]; other site 771875004402 L27 interface [polypeptide binding]; other site 771875004403 23S rRNA interface [nucleotide binding]; other site 771875004404 L5 interface [polypeptide binding]; other site 771875004405 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 771875004406 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 771875004407 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 771875004408 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 771875004409 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 771875004410 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 771875004411 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 771875004412 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 771875004413 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 771875004414 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 771875004415 RNA binding site [nucleotide binding]; other site 771875004416 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 771875004417 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 771875004418 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 771875004419 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 771875004420 putative translocon interaction site; other site 771875004421 23S rRNA interface [nucleotide binding]; other site 771875004422 signal recognition particle (SRP54) interaction site; other site 771875004423 L23 interface [polypeptide binding]; other site 771875004424 trigger factor interaction site; other site 771875004425 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 771875004426 23S rRNA interface [nucleotide binding]; other site 771875004427 5S rRNA interface [nucleotide binding]; other site 771875004428 putative antibiotic binding site [chemical binding]; other site 771875004429 L25 interface [polypeptide binding]; other site 771875004430 L27 interface [polypeptide binding]; other site 771875004431 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 771875004432 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 771875004433 G-X-X-G motif; other site 771875004434 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 771875004435 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 771875004436 putative translocon binding site; other site 771875004437 protein-rRNA interface [nucleotide binding]; other site 771875004438 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 771875004439 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 771875004440 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 771875004441 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 771875004442 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 771875004443 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 771875004444 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 771875004445 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 771875004446 elongation factor Tu; Reviewed; Region: PRK00049 771875004447 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 771875004448 G1 box; other site 771875004449 GEF interaction site [polypeptide binding]; other site 771875004450 GTP/Mg2+ binding site [chemical binding]; other site 771875004451 Switch I region; other site 771875004452 G2 box; other site 771875004453 G3 box; other site 771875004454 Switch II region; other site 771875004455 G4 box; other site 771875004456 G5 box; other site 771875004457 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 771875004458 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 771875004459 Antibiotic Binding Site [chemical binding]; other site 771875004460 elongation factor G; Reviewed; Region: PRK00007 771875004461 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 771875004462 G1 box; other site 771875004463 putative GEF interaction site [polypeptide binding]; other site 771875004464 GTP/Mg2+ binding site [chemical binding]; other site 771875004465 Switch I region; other site 771875004466 G2 box; other site 771875004467 G3 box; other site 771875004468 Switch II region; other site 771875004469 G4 box; other site 771875004470 G5 box; other site 771875004471 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 771875004472 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 771875004473 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 771875004474 30S ribosomal protein S7; Validated; Region: PRK05302 771875004475 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 771875004476 S17 interaction site [polypeptide binding]; other site 771875004477 S8 interaction site; other site 771875004478 16S rRNA interaction site [nucleotide binding]; other site 771875004479 streptomycin interaction site [chemical binding]; other site 771875004480 23S rRNA interaction site [nucleotide binding]; other site 771875004481 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 771875004482 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 771875004483 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 771875004484 NAD(P) binding site [chemical binding]; other site 771875004485 LDH/MDH dimer interface [polypeptide binding]; other site 771875004486 substrate binding site [chemical binding]; other site 771875004487 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 771875004488 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 771875004489 homodimer interface [polypeptide binding]; other site 771875004490 active site 771875004491 catalytic site [active] 771875004492 maltose binding site 2 [chemical binding]; other site 771875004493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875004494 putative substrate translocation pore; other site 771875004495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 771875004496 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 771875004497 diiron binding motif [ion binding]; other site 771875004498 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 771875004499 catalytic residues [active] 771875004500 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 771875004501 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 771875004502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 771875004503 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 771875004504 DHH family; Region: DHH; pfam01368 771875004505 FOG: CBS domain [General function prediction only]; Region: COG0517 771875004506 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 771875004507 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 771875004508 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 771875004509 active site 771875004510 NTP binding site [chemical binding]; other site 771875004511 metal binding triad [ion binding]; metal-binding site 771875004512 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 771875004513 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 771875004514 putative active site [active] 771875004515 putative metal binding site [ion binding]; other site 771875004516 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 771875004517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 771875004518 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 771875004519 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 771875004520 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 771875004521 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 771875004522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875004523 S-adenosylmethionine binding site [chemical binding]; other site 771875004524 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 771875004525 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14319 771875004526 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 771875004527 active site 771875004528 substrate binding site [chemical binding]; other site 771875004529 metal binding site [ion binding]; metal-binding site 771875004530 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875004531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004533 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875004534 Uncharacterized conserved protein [Function unknown]; Region: COG2013 771875004535 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 771875004536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875004537 active site 771875004538 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 771875004539 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 771875004540 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 771875004541 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 771875004542 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 771875004543 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 771875004544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875004545 motif II; other site 771875004546 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 771875004547 6-phosphofructokinase; Provisional; Region: PRK14072 771875004548 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 771875004549 active site 771875004550 ADP/pyrophosphate binding site [chemical binding]; other site 771875004551 dimerization interface [polypeptide binding]; other site 771875004552 allosteric effector site; other site 771875004553 fructose-1,6-bisphosphate binding site; other site 771875004554 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 771875004555 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 771875004556 glycogen binding site [chemical binding]; other site 771875004557 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 771875004558 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 771875004559 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 771875004560 Ca binding site [ion binding]; other site 771875004561 active site 771875004562 catalytic site [active] 771875004563 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 771875004564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 771875004565 Walker A/P-loop; other site 771875004566 ATP binding site [chemical binding]; other site 771875004567 Q-loop/lid; other site 771875004568 ABC transporter signature motif; other site 771875004569 Walker B; other site 771875004570 D-loop; other site 771875004571 H-loop/switch region; other site 771875004572 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 771875004573 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 771875004574 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 771875004575 Walker A/P-loop; other site 771875004576 ATP binding site [chemical binding]; other site 771875004577 Q-loop/lid; other site 771875004578 ABC transporter signature motif; other site 771875004579 Walker B; other site 771875004580 D-loop; other site 771875004581 H-loop/switch region; other site 771875004582 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 771875004583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 771875004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875004585 dimer interface [polypeptide binding]; other site 771875004586 conserved gate region; other site 771875004587 putative PBP binding loops; other site 771875004588 ABC-ATPase subunit interface; other site 771875004589 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 771875004590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 771875004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875004592 dimer interface [polypeptide binding]; other site 771875004593 conserved gate region; other site 771875004594 putative PBP binding loops; other site 771875004595 ABC-ATPase subunit interface; other site 771875004596 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 771875004597 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 771875004598 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 771875004599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875004600 Zn2+ binding site [ion binding]; other site 771875004601 Mg2+ binding site [ion binding]; other site 771875004602 Type III pantothenate kinase; Region: Pan_kinase; cl17198 771875004603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875004604 Radical SAM superfamily; Region: Radical_SAM; pfam04055 771875004605 FeS/SAM binding site; other site 771875004606 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 771875004607 putative substrate binding region [chemical binding]; other site 771875004608 glutamate racemase; Provisional; Region: PRK00865 771875004609 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 771875004610 AAA domain; Region: AAA_18; pfam13238 771875004611 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 771875004612 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 771875004613 phosphate binding site [ion binding]; other site 771875004614 putative substrate binding pocket [chemical binding]; other site 771875004615 dimer interface [polypeptide binding]; other site 771875004616 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 771875004617 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 771875004618 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 771875004619 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 771875004620 ATP cone domain; Region: ATP-cone; pfam03477 771875004621 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 771875004622 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 771875004623 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 771875004624 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 771875004625 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 771875004626 dimer interface [polypeptide binding]; other site 771875004627 putative anticodon binding site; other site 771875004628 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 771875004629 motif 1; other site 771875004630 active site 771875004631 motif 2; other site 771875004632 motif 3; other site 771875004633 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 771875004634 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 771875004635 C factor cell-cell signaling protein; Provisional; Region: PRK09009 771875004636 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 771875004637 NADP binding site [chemical binding]; other site 771875004638 homodimer interface [polypeptide binding]; other site 771875004639 active site 771875004640 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 771875004641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 771875004642 dimer interface [polypeptide binding]; other site 771875004643 putative CheW interface [polypeptide binding]; other site 771875004644 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 771875004645 purine monophosphate binding site [chemical binding]; other site 771875004646 dimer interface [polypeptide binding]; other site 771875004647 putative catalytic residues [active] 771875004648 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 771875004649 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 771875004650 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875004651 active site 771875004652 metal binding site [ion binding]; metal-binding site 771875004653 AAA domain; Region: AAA_23; pfam13476 771875004654 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 771875004655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875004656 ABC transporter signature motif; other site 771875004657 Walker B; other site 771875004658 D-loop; other site 771875004659 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875004660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004662 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875004663 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 771875004664 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 771875004665 NAD binding site [chemical binding]; other site 771875004666 homodimer interface [polypeptide binding]; other site 771875004667 active site 771875004668 substrate binding site [chemical binding]; other site 771875004669 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 771875004670 Dimer interface [polypeptide binding]; other site 771875004671 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 771875004672 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 771875004673 MOFRL family; Region: MOFRL; pfam05161 771875004674 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 771875004675 fructuronate transporter; Provisional; Region: PRK10034; cl15264 771875004676 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 771875004677 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 771875004678 MutS domain I; Region: MutS_I; pfam01624 771875004679 MutS domain II; Region: MutS_II; pfam05188 771875004680 MutS domain III; Region: MutS_III; pfam05192 771875004681 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 771875004682 Walker A/P-loop; other site 771875004683 ATP binding site [chemical binding]; other site 771875004684 Q-loop/lid; other site 771875004685 ABC transporter signature motif; other site 771875004686 Walker B; other site 771875004687 D-loop; other site 771875004688 H-loop/switch region; other site 771875004689 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 771875004690 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 771875004691 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 771875004692 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 771875004693 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 771875004694 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 771875004695 Walker A/P-loop; other site 771875004696 ATP binding site [chemical binding]; other site 771875004697 Q-loop/lid; other site 771875004698 ABC transporter signature motif; other site 771875004699 Walker B; other site 771875004700 D-loop; other site 771875004701 H-loop/switch region; other site 771875004702 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 771875004703 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 771875004704 Walker A/P-loop; other site 771875004705 ATP binding site [chemical binding]; other site 771875004706 Q-loop/lid; other site 771875004707 ABC transporter signature motif; other site 771875004708 Walker B; other site 771875004709 D-loop; other site 771875004710 H-loop/switch region; other site 771875004711 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 771875004712 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 771875004713 TM-ABC transporter signature motif; other site 771875004714 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875004715 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 771875004716 TM-ABC transporter signature motif; other site 771875004717 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 771875004718 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 771875004719 putative ligand binding site [chemical binding]; other site 771875004720 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 771875004721 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 771875004722 putative ligand binding site [chemical binding]; other site 771875004723 Flavoprotein; Region: Flavoprotein; pfam02441 771875004724 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 771875004725 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 771875004726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 771875004727 FOG: CBS domain [General function prediction only]; Region: COG0517 771875004728 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 771875004729 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 771875004730 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 771875004731 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 771875004732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 771875004733 Walker A motif; other site 771875004734 ATP binding site [chemical binding]; other site 771875004735 Walker B motif; other site 771875004736 arginine finger; other site 771875004737 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 771875004738 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 771875004739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875004740 active site 771875004741 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 771875004742 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 771875004743 active site 771875004744 dimer interface [polypeptide binding]; other site 771875004745 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 771875004746 dimer interface [polypeptide binding]; other site 771875004747 active site 771875004748 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 771875004749 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 771875004750 CoA-binding site [chemical binding]; other site 771875004751 ATP-binding [chemical binding]; other site 771875004752 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 771875004753 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 771875004754 homodimer interface [polypeptide binding]; other site 771875004755 NAD binding pocket [chemical binding]; other site 771875004756 ATP binding pocket [chemical binding]; other site 771875004757 Mg binding site [ion binding]; other site 771875004758 active-site loop [active] 771875004759 Uncharacterized conserved protein [Function unknown]; Region: COG1656 771875004760 Protein of unknown function DUF82; Region: DUF82; pfam01927 771875004761 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 771875004762 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 771875004763 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 771875004764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875004765 putative active site [active] 771875004766 heme pocket [chemical binding]; other site 771875004767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 771875004768 dimer interface [polypeptide binding]; other site 771875004769 phosphorylation site [posttranslational modification] 771875004770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875004771 ATP binding site [chemical binding]; other site 771875004772 Mg2+ binding site [ion binding]; other site 771875004773 G-X-G motif; other site 771875004774 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 771875004775 tetramerization interface [polypeptide binding]; other site 771875004776 active site 771875004777 Protein of unknown function (DUF342); Region: DUF342; pfam03961 771875004778 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 771875004779 acyl carrier protein; Provisional; Region: acpP; PRK00982 771875004780 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 771875004781 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 771875004782 active site 771875004783 Zn binding site [ion binding]; other site 771875004784 GTP-binding protein LepA; Provisional; Region: PRK05433 771875004785 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 771875004786 G1 box; other site 771875004787 putative GEF interaction site [polypeptide binding]; other site 771875004788 GTP/Mg2+ binding site [chemical binding]; other site 771875004789 Switch I region; other site 771875004790 G2 box; other site 771875004791 G3 box; other site 771875004792 Switch II region; other site 771875004793 G4 box; other site 771875004794 G5 box; other site 771875004795 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 771875004796 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 771875004797 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 771875004798 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 771875004799 Mechanosensitive ion channel; Region: MS_channel; pfam00924 771875004800 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 771875004801 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 771875004802 active site 771875004803 HIGH motif; other site 771875004804 dimer interface [polypeptide binding]; other site 771875004805 KMSKS motif; other site 771875004806 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 771875004807 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 771875004808 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 771875004809 AAA domain; Region: AAA_14; pfam13173 771875004810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 771875004811 sequence-specific DNA binding site [nucleotide binding]; other site 771875004812 salt bridge; other site 771875004813 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 771875004814 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 771875004815 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 771875004816 reverse gyrase; Reviewed; Region: PRK09401 771875004817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 771875004818 ATP binding site [chemical binding]; other site 771875004819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 771875004820 nucleotide binding region [chemical binding]; other site 771875004821 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 771875004822 active site 771875004823 metal binding site [ion binding]; metal-binding site 771875004824 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 771875004825 domain I; other site 771875004826 DNA binding groove [nucleotide binding] 771875004827 phosphate binding site [ion binding]; other site 771875004828 domain II; other site 771875004829 domain III; other site 771875004830 nucleotide binding site [chemical binding]; other site 771875004831 catalytic site [active] 771875004832 domain IV; other site 771875004833 recombination protein F; Reviewed; Region: recF; PRK00064 771875004834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875004835 Walker A/P-loop; other site 771875004836 ATP binding site [chemical binding]; other site 771875004837 Q-loop/lid; other site 771875004838 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 771875004839 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 771875004840 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336 771875004841 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 771875004842 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 771875004843 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 771875004844 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 771875004845 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 771875004846 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 771875004847 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 771875004848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 771875004849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 771875004850 Mg2+ binding site [ion binding]; other site 771875004851 G-X-G motif; other site 771875004852 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 771875004853 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 771875004854 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 771875004855 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 771875004856 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 771875004857 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 771875004858 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 771875004859 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 771875004860 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 771875004861 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 771875004862 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875004863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875004865 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875004866 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 771875004867 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 771875004868 nucleotide binding site [chemical binding]; other site 771875004869 NEF interaction site [polypeptide binding]; other site 771875004870 SBD interface [polypeptide binding]; other site 771875004871 aspartate aminotransferase; Provisional; Region: PRK07568 771875004872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 771875004873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875004874 homodimer interface [polypeptide binding]; other site 771875004875 catalytic residue [active] 771875004876 Uncharacterized conserved protein [Function unknown]; Region: COG1739 771875004877 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 771875004878 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 771875004879 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875004880 active site 771875004881 metal binding site [ion binding]; metal-binding site 771875004882 homotetramer interface [polypeptide binding]; other site 771875004883 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 771875004884 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 771875004885 PrcB C-terminal; Region: PrcB_C; pfam14343 771875004886 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875004887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875004888 metal binding site [ion binding]; metal-binding site 771875004889 active site 771875004890 I-site; other site 771875004891 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875004892 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875004893 Integrase core domain; Region: rve; pfam00665 771875004894 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 771875004895 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 771875004896 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 771875004897 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 771875004898 G1 box; other site 771875004899 putative GEF interaction site [polypeptide binding]; other site 771875004900 GTP/Mg2+ binding site [chemical binding]; other site 771875004901 Switch I region; other site 771875004902 G2 box; other site 771875004903 G3 box; other site 771875004904 Switch II region; other site 771875004905 G4 box; other site 771875004906 G5 box; other site 771875004907 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 771875004908 Translation-initiation factor 2; Region: IF-2; pfam11987 771875004909 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 771875004910 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875004911 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875004912 Integrase core domain; Region: rve; pfam00665 771875004913 CAAX protease self-immunity; Region: Abi; pfam02517 771875004914 DNA photolyase; Region: DNA_photolyase; pfam00875 771875004915 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 771875004916 DNA photolyase; Region: DNA_photolyase; pfam00875 771875004917 Archaeal ATPase; Region: Arch_ATPase; pfam01637 771875004918 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875004919 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875004920 Integrase core domain; Region: rve; pfam00665 771875004921 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 771875004922 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 771875004923 GIY-YIG motif/motif A; other site 771875004924 putative active site [active] 771875004925 putative metal binding site [ion binding]; other site 771875004926 photolyase PhrII; Region: phr2; TIGR00591 771875004927 DNA photolyase; Region: DNA_photolyase; pfam00875 771875004928 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 771875004929 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 771875004930 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 771875004931 Dimer interface [polypeptide binding]; other site 771875004932 anticodon binding site; other site 771875004933 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 771875004934 homodimer interface [polypeptide binding]; other site 771875004935 motif 1; other site 771875004936 motif 2; other site 771875004937 active site 771875004938 motif 3; other site 771875004939 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 771875004940 NlpC/P60 family; Region: NLPC_P60; cl17555 771875004941 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 771875004942 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 771875004943 putative active site [active] 771875004944 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 771875004945 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 771875004946 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 771875004947 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 771875004948 beta-phosphoglucomutase; Region: bPGM; TIGR01990 771875004949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875004950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875004951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875004952 dimer interface [polypeptide binding]; other site 771875004953 conserved gate region; other site 771875004954 putative PBP binding loops; other site 771875004955 ABC-ATPase subunit interface; other site 771875004956 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 771875004957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875004958 dimer interface [polypeptide binding]; other site 771875004959 conserved gate region; other site 771875004960 putative PBP binding loops; other site 771875004961 ABC-ATPase subunit interface; other site 771875004962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875004963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875004964 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875004965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875004966 DNA binding site [nucleotide binding] 771875004967 domain linker motif; other site 771875004968 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875004969 ligand binding site [chemical binding]; other site 771875004970 dimerization interface [polypeptide binding]; other site 771875004971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 771875004972 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 771875004973 Coenzyme A binding pocket [chemical binding]; other site 771875004974 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 771875004975 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 771875004976 GTP/Mg2+ binding site [chemical binding]; other site 771875004977 G4 box; other site 771875004978 G5 box; other site 771875004979 G1 box; other site 771875004980 Switch I region; other site 771875004981 G2 box; other site 771875004982 G3 box; other site 771875004983 Switch II region; other site 771875004984 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 771875004985 Propanediol utilisation protein PduL; Region: PduL; pfam06130 771875004986 Propanediol utilisation protein PduL; Region: PduL; pfam06130 771875004987 Ubiquitin-like proteins; Region: UBQ; cl00155 771875004988 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 771875004989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875004990 Zn2+ binding site [ion binding]; other site 771875004991 Mg2+ binding site [ion binding]; other site 771875004992 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 771875004993 DNA polymerase III subunit beta; Validated; Region: PRK05643 771875004994 putative DNA binding surface [nucleotide binding]; other site 771875004995 dimer interface [polypeptide binding]; other site 771875004996 beta-clamp/clamp loader binding surface; other site 771875004997 beta-clamp/translesion DNA polymerase binding surface; other site 771875004998 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 771875004999 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 771875005000 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 771875005001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 771875005002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 771875005003 Walker A/P-loop; other site 771875005004 ATP binding site [chemical binding]; other site 771875005005 Q-loop/lid; other site 771875005006 ABC transporter signature motif; other site 771875005007 Walker B; other site 771875005008 D-loop; other site 771875005009 H-loop/switch region; other site 771875005010 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 771875005011 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 771875005012 Coenzyme A binding pocket [chemical binding]; other site 771875005013 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 771875005014 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 771875005015 NAD(P) binding pocket [chemical binding]; other site 771875005016 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 771875005017 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 771875005018 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 771875005019 Walker A; other site 771875005020 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 771875005021 B12 binding site [chemical binding]; other site 771875005022 cobalt ligand [ion binding]; other site 771875005023 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 771875005024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 771875005025 phage assembly protein; Region: IV; PHA00019 771875005026 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 771875005027 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 771875005028 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 771875005029 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 771875005030 carboxyltransferase (CT) interaction site; other site 771875005031 biotinylation site [posttranslational modification]; other site 771875005032 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 771875005033 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 771875005034 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 771875005035 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 771875005036 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 771875005037 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 771875005038 dimer interface [polypeptide binding]; other site 771875005039 substrate binding site [chemical binding]; other site 771875005040 metal binding site [ion binding]; metal-binding site 771875005041 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 771875005042 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 771875005043 ligand binding site [chemical binding]; other site 771875005044 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 771875005045 ligand binding site [chemical binding]; other site 771875005046 flexible hinge region; other site 771875005047 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 771875005048 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 771875005049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 771875005050 nucleotide binding region [chemical binding]; other site 771875005051 ATP-binding site [chemical binding]; other site 771875005052 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 771875005053 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 771875005054 dimer interface [polypeptide binding]; other site 771875005055 PYR/PP interface [polypeptide binding]; other site 771875005056 TPP binding site [chemical binding]; other site 771875005057 substrate binding site [chemical binding]; other site 771875005058 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 771875005059 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 771875005060 Ferredoxin [Energy production and conversion]; Region: COG1146 771875005061 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 771875005062 isoaspartyl dipeptidase; Provisional; Region: PRK10657 771875005063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 771875005064 active site 771875005065 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 771875005066 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 771875005067 substrate-cofactor binding pocket; other site 771875005068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875005069 catalytic residue [active] 771875005070 Threonine dehydrogenase; Region: TDH; cd05281 771875005071 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 771875005072 structural Zn binding site [ion binding]; other site 771875005073 catalytic Zn binding site [ion binding]; other site 771875005074 tetramer interface [polypeptide binding]; other site 771875005075 NADP binding site [chemical binding]; other site 771875005076 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 771875005077 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 771875005078 ligand binding site [chemical binding]; other site 771875005079 flexible hinge region; other site 771875005080 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 771875005081 putative switch regulator; other site 771875005082 non-specific DNA interactions [nucleotide binding]; other site 771875005083 DNA binding site [nucleotide binding] 771875005084 sequence specific DNA binding site [nucleotide binding]; other site 771875005085 putative cAMP binding site [chemical binding]; other site 771875005086 hydroxylamine reductase; Provisional; Region: PRK12310 771875005087 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 771875005088 cubane metal cluster [ion binding]; other site 771875005089 hybrid metal cluster; other site 771875005090 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 771875005091 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 771875005092 active site 771875005093 metal binding site [ion binding]; metal-binding site 771875005094 PQQ-like domain; Region: PQQ_2; pfam13360 771875005095 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875005096 Trp docking motif [polypeptide binding]; other site 771875005097 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875005098 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 771875005099 non-specific DNA interactions [nucleotide binding]; other site 771875005100 DNA binding site [nucleotide binding] 771875005101 sequence specific DNA binding site [nucleotide binding]; other site 771875005102 putative cAMP binding site [chemical binding]; other site 771875005103 Protein of unknown function (DUF523); Region: DUF523; pfam04463 771875005104 Uncharacterized conserved protein [Function unknown]; Region: COG3272 771875005105 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 771875005106 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 771875005107 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 771875005108 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 771875005109 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 771875005110 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 771875005111 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 771875005112 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 771875005113 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 771875005114 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 771875005115 phosphodiesterase; Provisional; Region: PRK12704 771875005116 KH domain; Region: KH_1; pfam00013 771875005117 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875005118 Zn2+ binding site [ion binding]; other site 771875005119 Mg2+ binding site [ion binding]; other site 771875005120 RecX family; Region: RecX; pfam02631 771875005121 recombinase A; Provisional; Region: recA; PRK09354 771875005122 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 771875005123 hexamer interface [polypeptide binding]; other site 771875005124 Walker A motif; other site 771875005125 ATP binding site [chemical binding]; other site 771875005126 Walker B motif; other site 771875005127 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 771875005128 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 771875005129 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 771875005130 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 771875005131 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 771875005132 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 771875005133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875005134 FeS/SAM binding site; other site 771875005135 TRAM domain; Region: TRAM; pfam01938 771875005136 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 771875005137 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 771875005138 Uncharacterized conserved protein [Function unknown]; Region: COG1656 771875005139 Protein of unknown function DUF82; Region: DUF82; pfam01927 771875005140 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 771875005141 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 771875005142 GDP-binding site [chemical binding]; other site 771875005143 ACT binding site; other site 771875005144 IMP binding site; other site 771875005145 Acylphosphatase; Region: Acylphosphatase; pfam00708 771875005146 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 771875005147 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 771875005148 nucleotide binding site [chemical binding]; other site 771875005149 substrate binding site [chemical binding]; other site 771875005150 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 771875005151 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 771875005152 Domain of unknown function DUF39; Region: DUF39; pfam01837 771875005153 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 771875005154 4Fe-4S binding domain; Region: Fer4_6; pfam12837 771875005155 hypothetical protein; Provisional; Region: PRK04334 771875005156 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 771875005157 FAD binding site [chemical binding]; other site 771875005158 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 771875005159 GPI transamidase subunit PIG-U; Region: PIG-U; pfam06728 771875005160 Acyltransferase family; Region: Acyl_transf_3; pfam01757 771875005161 PAS fold; Region: PAS_4; pfam08448 771875005162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875005163 putative active site [active] 771875005164 heme pocket [chemical binding]; other site 771875005165 PAS domain S-box; Region: sensory_box; TIGR00229 771875005166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 771875005167 putative active site [active] 771875005168 heme pocket [chemical binding]; other site 771875005169 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 771875005170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 771875005171 dimer interface [polypeptide binding]; other site 771875005172 phosphorylation site [posttranslational modification] 771875005173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875005174 ATP binding site [chemical binding]; other site 771875005175 Mg2+ binding site [ion binding]; other site 771875005176 G-X-G motif; other site 771875005177 Response regulator receiver domain; Region: Response_reg; pfam00072 771875005178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875005179 active site 771875005180 phosphorylation site [posttranslational modification] 771875005181 intermolecular recognition site; other site 771875005182 dimerization interface [polypeptide binding]; other site 771875005183 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 771875005184 putative binding surface; other site 771875005185 active site 771875005186 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 771875005187 GAF domain; Region: GAF; pfam01590 771875005188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875005189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875005190 metal binding site [ion binding]; metal-binding site 771875005191 active site 771875005192 I-site; other site 771875005193 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 771875005194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875005195 S-adenosylmethionine binding site [chemical binding]; other site 771875005196 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 771875005197 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 771875005198 Walker A/P-loop; other site 771875005199 ATP binding site [chemical binding]; other site 771875005200 Q-loop/lid; other site 771875005201 ABC transporter signature motif; other site 771875005202 Walker B; other site 771875005203 D-loop; other site 771875005204 H-loop/switch region; other site 771875005205 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 771875005206 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 771875005207 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 771875005208 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 771875005209 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 771875005210 putative ligand binding pocket/active site [active] 771875005211 putative metal binding site [ion binding]; other site 771875005212 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 771875005213 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 771875005214 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 771875005215 trimerization site [polypeptide binding]; other site 771875005216 active site 771875005217 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 771875005218 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 771875005219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 771875005220 catalytic residue [active] 771875005221 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 771875005222 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 771875005223 FeS assembly protein SufB; Region: sufB; TIGR01980 771875005224 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 771875005225 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 771875005226 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 771875005227 Walker A/P-loop; other site 771875005228 ATP binding site [chemical binding]; other site 771875005229 Q-loop/lid; other site 771875005230 ABC transporter signature motif; other site 771875005231 Walker B; other site 771875005232 D-loop; other site 771875005233 H-loop/switch region; other site 771875005234 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 771875005235 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 771875005236 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 771875005237 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 771875005238 Walker A/P-loop; other site 771875005239 ATP binding site [chemical binding]; other site 771875005240 Q-loop/lid; other site 771875005241 ABC transporter signature motif; other site 771875005242 Walker B; other site 771875005243 D-loop; other site 771875005244 H-loop/switch region; other site 771875005245 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 771875005246 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 771875005247 Walker A/P-loop; other site 771875005248 ATP binding site [chemical binding]; other site 771875005249 Q-loop/lid; other site 771875005250 ABC transporter signature motif; other site 771875005251 Walker B; other site 771875005252 D-loop; other site 771875005253 H-loop/switch region; other site 771875005254 Peptidase family M48; Region: Peptidase_M48; pfam01435 771875005255 Staphylococcal nuclease homologues; Region: SNc; smart00318 771875005256 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 771875005257 Catalytic site; other site 771875005258 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 771875005259 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 771875005260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875005261 Walker A/P-loop; other site 771875005262 ATP binding site [chemical binding]; other site 771875005263 Q-loop/lid; other site 771875005264 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 771875005265 ABC transporter signature motif; other site 771875005266 Walker B; other site 771875005267 D-loop; other site 771875005268 H-loop/switch region; other site 771875005269 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 771875005270 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 771875005271 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 771875005272 TM-ABC transporter signature motif; other site 771875005273 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 771875005274 TM-ABC transporter signature motif; other site 771875005275 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 771875005276 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 771875005277 TAP-like protein; Region: Abhydrolase_4; pfam08386 771875005278 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 771875005279 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 771875005280 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875005281 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875005282 Integrase core domain; Region: rve; pfam00665 771875005283 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 771875005284 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 771875005285 putative dimer interface [polypeptide binding]; other site 771875005286 active site pocket [active] 771875005287 putative cataytic base [active] 771875005288 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 771875005289 homotrimer interface [polypeptide binding]; other site 771875005290 Walker A motif; other site 771875005291 GTP binding site [chemical binding]; other site 771875005292 Walker B motif; other site 771875005293 cobalamin synthase; Reviewed; Region: cobS; PRK00235 771875005294 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 771875005295 AAA domain; Region: AAA_26; pfam13500 771875005296 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 771875005297 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 771875005298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 771875005299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 771875005300 homodimer interface [polypeptide binding]; other site 771875005301 catalytic residue [active] 771875005302 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 771875005303 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 771875005304 homodimer interface [polypeptide binding]; other site 771875005305 Walker A motif; other site 771875005306 ATP binding site [chemical binding]; other site 771875005307 hydroxycobalamin binding site [chemical binding]; other site 771875005308 Walker B motif; other site 771875005309 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 771875005310 DpnII restriction endonuclease; Region: DpnII; pfam04556 771875005311 DNA methylase; Region: N6_N4_Mtase; pfam01555 771875005312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875005313 S-adenosylmethionine binding site [chemical binding]; other site 771875005314 DNA methylase; Region: N6_N4_Mtase; cl17433 771875005315 HEAT repeats; Region: HEAT_2; pfam13646 771875005316 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 771875005317 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 771875005318 protein binding surface [polypeptide binding]; other site 771875005319 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 771875005320 protein binding surface [polypeptide binding]; other site 771875005321 HEAT repeats; Region: HEAT_2; pfam13646 771875005322 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 771875005323 HEAT repeats; Region: HEAT_2; pfam13646 771875005324 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 771875005325 protein binding surface [polypeptide binding]; other site 771875005326 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 771875005327 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 771875005328 protein binding surface [polypeptide binding]; other site 771875005329 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 771875005330 protein binding surface [polypeptide binding]; other site 771875005331 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 771875005332 protein binding surface [polypeptide binding]; other site 771875005333 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 771875005334 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 771875005335 HEAT repeats; Region: HEAT_2; pfam13646 771875005336 HEAT repeats; Region: HEAT_2; pfam13646 771875005337 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 771875005338 HEAT repeats; Region: HEAT_2; pfam13646 771875005339 protein binding surface [polypeptide binding]; other site 771875005340 Transposase domain (DUF772); Region: DUF772; pfam05598 771875005341 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 771875005342 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 771875005343 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 771875005344 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 771875005345 NAD binding site [chemical binding]; other site 771875005346 sugar binding site [chemical binding]; other site 771875005347 divalent metal binding site [ion binding]; other site 771875005348 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 771875005349 dimer interface [polypeptide binding]; other site 771875005350 Domain of unknown function (DUF377); Region: DUF377; pfam04041 771875005351 Glycosyl hydrolase family 43 containing a domain of unknown function; Region: GH43_DUF377; cd08993 771875005352 active site 771875005353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875005354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005355 dimer interface [polypeptide binding]; other site 771875005356 conserved gate region; other site 771875005357 putative PBP binding loops; other site 771875005358 ABC-ATPase subunit interface; other site 771875005359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 771875005360 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 771875005361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005362 putative PBP binding loops; other site 771875005363 dimer interface [polypeptide binding]; other site 771875005364 ABC-ATPase subunit interface; other site 771875005365 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875005366 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875005367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875005368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875005369 DNA binding site [nucleotide binding] 771875005370 domain linker motif; other site 771875005371 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 771875005372 Uncharacterized conserved protein [Function unknown]; Region: COG1572 771875005373 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 771875005374 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 771875005375 glycogen binding site [chemical binding]; other site 771875005376 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 771875005377 glycogen binding site [chemical binding]; other site 771875005378 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 771875005379 putative ligand binding site [chemical binding]; other site 771875005380 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 771875005381 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 771875005382 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 771875005383 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875005384 CAAX protease self-immunity; Region: Abi; pfam02517 771875005385 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 771875005386 DDE domain; Region: DDE_Tnp_IS240; pfam13610 771875005387 Integrase core domain; Region: rve; pfam00665 771875005388 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 771875005389 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 771875005390 active site 771875005391 catalytic tetrad [active] 771875005392 Part of AAA domain; Region: AAA_19; pfam13245 771875005393 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 771875005394 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 771875005395 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 771875005396 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 771875005397 nudix motif; other site 771875005398 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 771875005399 DNA methylase; Region: N6_N4_Mtase; pfam01555 771875005400 Ligand Binding Site [chemical binding]; other site 771875005401 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 771875005402 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 771875005403 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 771875005404 dimerization interface [polypeptide binding]; other site 771875005405 active site 771875005406 Quinolinate synthetase A protein; Region: NadA; pfam02445 771875005407 L-aspartate dehydrogenase; Provisional; Region: PRK13303 771875005408 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 771875005409 Domain of unknown function DUF108; Region: DUF108; pfam01958 771875005410 PQQ-like domain; Region: PQQ_2; pfam13360 771875005411 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 771875005412 Trp docking motif [polypeptide binding]; other site 771875005413 active site 771875005414 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 771875005415 putative catalytic site [active] 771875005416 putative metal binding site [ion binding]; other site 771875005417 putative phosphate binding site [ion binding]; other site 771875005418 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 771875005419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 771875005420 non-specific DNA binding site [nucleotide binding]; other site 771875005421 salt bridge; other site 771875005422 sequence-specific DNA binding site [nucleotide binding]; other site 771875005423 Cupin domain; Region: Cupin_2; pfam07883 771875005424 spermidine synthase; Provisional; Region: PRK00811 771875005425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875005426 S-adenosylmethionine binding site [chemical binding]; other site 771875005427 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 771875005428 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 771875005429 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 771875005430 Predicted methyltransferases [General function prediction only]; Region: COG0313 771875005431 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 771875005432 putative SAM binding site [chemical binding]; other site 771875005433 putative homodimer interface [polypeptide binding]; other site 771875005434 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 771875005435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875005436 S-adenosylmethionine binding site [chemical binding]; other site 771875005437 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 771875005438 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 771875005439 PGAP1-like protein; Region: PGAP1; pfam07819 771875005440 Protein of unknown function (DUF3242); Region: DUF3242; pfam11586 771875005441 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 771875005442 RNA/DNA hybrid binding site [nucleotide binding]; other site 771875005443 active site 771875005444 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 771875005445 DRTGG domain; Region: DRTGG; pfam07085 771875005446 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 771875005447 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 771875005448 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 771875005449 homodimer interface [polypeptide binding]; other site 771875005450 NADP binding site [chemical binding]; other site 771875005451 substrate binding site [chemical binding]; other site 771875005452 Preprotein translocase subunit; Region: YajC; cl00806 771875005453 protein-export membrane protein SecD; Region: secD; TIGR01129 771875005454 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 771875005455 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 771875005456 Protein export membrane protein; Region: SecD_SecF; pfam02355 771875005457 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 771875005458 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 771875005459 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 771875005460 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 771875005461 active site 771875005462 ADP/pyrophosphate binding site [chemical binding]; other site 771875005463 dimerization interface [polypeptide binding]; other site 771875005464 allosteric effector site; other site 771875005465 fructose-1,6-bisphosphate binding site; other site 771875005466 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 771875005467 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 771875005468 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 771875005469 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 771875005470 putative active site [active] 771875005471 metal binding site [ion binding]; metal-binding site 771875005472 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 771875005473 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 771875005474 metal-binding site [ion binding] 771875005475 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 771875005476 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 771875005477 metal-binding site [ion binding] 771875005478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 771875005479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875005480 motif II; other site 771875005481 Iron permease FTR1 family; Region: FTR1; cl00475 771875005482 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 771875005483 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 771875005484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 771875005485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 771875005486 metal binding site [ion binding]; metal-binding site 771875005487 active site 771875005488 I-site; other site 771875005489 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 771875005490 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 771875005491 putative substrate binding site [chemical binding]; other site 771875005492 putative ATP binding site [chemical binding]; other site 771875005493 Domain of unknown function (DUF377); Region: DUF377; pfam04041 771875005494 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 771875005495 active site 771875005496 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 771875005497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005498 dimer interface [polypeptide binding]; other site 771875005499 conserved gate region; other site 771875005500 putative PBP binding loops; other site 771875005501 ABC-ATPase subunit interface; other site 771875005502 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 771875005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 771875005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005505 ABC-ATPase subunit interface; other site 771875005506 putative PBP binding loops; other site 771875005507 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 771875005508 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 771875005509 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875005510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875005511 DNA binding site [nucleotide binding] 771875005512 domain linker motif; other site 771875005513 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 771875005514 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 771875005515 glycogen binding site [chemical binding]; other site 771875005516 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 771875005517 glycogen binding site [chemical binding]; other site 771875005518 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 771875005519 putative ligand binding site [chemical binding]; other site 771875005520 benzoate transport; Region: 2A0115; TIGR00895 771875005521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 771875005522 putative substrate translocation pore; other site 771875005523 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 771875005524 HSP70 interaction site [polypeptide binding]; other site 771875005525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875005526 binding surface 771875005527 TPR motif; other site 771875005528 TPR repeat; Region: TPR_11; pfam13414 771875005529 TPR repeat; Region: TPR_11; pfam13414 771875005530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875005531 binding surface 771875005532 TPR motif; other site 771875005533 TPR repeat; Region: TPR_11; pfam13414 771875005534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875005535 binding surface 771875005536 TPR motif; other site 771875005537 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 771875005538 nucleotide binding site/active site [active] 771875005539 HIT family signature motif; other site 771875005540 catalytic residue [active] 771875005541 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 771875005542 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 771875005543 HIGH motif; other site 771875005544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 771875005545 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 771875005546 active site 771875005547 KMSKS motif; other site 771875005548 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 771875005549 tRNA binding surface [nucleotide binding]; other site 771875005550 anticodon binding site; other site 771875005551 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 771875005552 Response regulator receiver domain; Region: Response_reg; pfam00072 771875005553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875005554 active site 771875005555 phosphorylation site [posttranslational modification] 771875005556 intermolecular recognition site; other site 771875005557 dimerization interface [polypeptide binding]; other site 771875005558 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 771875005559 carbohydrate binding site [chemical binding]; other site 771875005560 pullulanase, type I; Region: pulA_typeI; TIGR02104 771875005561 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 771875005562 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 771875005563 Ca binding site [ion binding]; other site 771875005564 active site 771875005565 catalytic site [active] 771875005566 phosphate binding protein; Region: ptsS_2; TIGR02136 771875005567 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 771875005568 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 771875005569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005570 dimer interface [polypeptide binding]; other site 771875005571 conserved gate region; other site 771875005572 putative PBP binding loops; other site 771875005573 ABC-ATPase subunit interface; other site 771875005574 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 771875005575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005576 dimer interface [polypeptide binding]; other site 771875005577 conserved gate region; other site 771875005578 putative PBP binding loops; other site 771875005579 ABC-ATPase subunit interface; other site 771875005580 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 771875005581 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 771875005582 Walker A/P-loop; other site 771875005583 ATP binding site [chemical binding]; other site 771875005584 Q-loop/lid; other site 771875005585 ABC transporter signature motif; other site 771875005586 Walker B; other site 771875005587 D-loop; other site 771875005588 H-loop/switch region; other site 771875005589 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 771875005590 PhoU domain; Region: PhoU; pfam01895 771875005591 PhoU domain; Region: PhoU; pfam01895 771875005592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 771875005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875005594 active site 771875005595 phosphorylation site [posttranslational modification] 771875005596 intermolecular recognition site; other site 771875005597 dimerization interface [polypeptide binding]; other site 771875005598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 771875005599 DNA binding site [nucleotide binding] 771875005600 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 771875005601 PAS domain; Region: PAS_8; pfam13188 771875005602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 771875005603 dimer interface [polypeptide binding]; other site 771875005604 phosphorylation site [posttranslational modification] 771875005605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875005606 ATP binding site [chemical binding]; other site 771875005607 Mg2+ binding site [ion binding]; other site 771875005608 G-X-G motif; other site 771875005609 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 771875005610 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 771875005611 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 771875005612 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 771875005613 G1 box; other site 771875005614 putative GEF interaction site [polypeptide binding]; other site 771875005615 GTP/Mg2+ binding site [chemical binding]; other site 771875005616 Switch I region; other site 771875005617 G2 box; other site 771875005618 G3 box; other site 771875005619 Switch II region; other site 771875005620 G4 box; other site 771875005621 G5 box; other site 771875005622 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 771875005623 Translation-initiation factor 2; Region: IF-2; pfam11987 771875005624 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 771875005625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 771875005626 NAD(P) binding site [chemical binding]; other site 771875005627 active site 771875005628 MarR family; Region: MarR_2; pfam12802 771875005629 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 771875005630 active site 771875005631 metal-binding site [ion binding] 771875005632 nucleotide-binding site [chemical binding]; other site 771875005633 peroxiredoxin; Provisional; Region: PRK13189 771875005634 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 771875005635 dimer interface [polypeptide binding]; other site 771875005636 decamer (pentamer of dimers) interface [polypeptide binding]; other site 771875005637 catalytic triad [active] 771875005638 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 771875005639 homodimer interface [polypeptide binding]; other site 771875005640 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 771875005641 active site pocket [active] 771875005642 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 771875005643 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 771875005644 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 771875005645 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 771875005646 ATP-grasp domain; Region: ATP-grasp_4; cl17255 771875005647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875005648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875005649 DNA binding site [nucleotide binding] 771875005650 domain linker motif; other site 771875005651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875005652 dimerization interface [polypeptide binding]; other site 771875005653 ligand binding site [chemical binding]; other site 771875005654 competence damage-inducible protein A; Provisional; Region: PRK00549 771875005655 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 771875005656 putative MPT binding site; other site 771875005657 Competence-damaged protein; Region: CinA; pfam02464 771875005658 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875005659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875005660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 771875005661 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875005662 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 771875005663 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 771875005664 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290 771875005665 CotH protein; Region: CotH; pfam08757 771875005666 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 771875005667 Na2 binding site [ion binding]; other site 771875005668 substrate binding site 1 [chemical binding]; other site 771875005669 Na binding site 1 [ion binding]; other site 771875005670 substrate binding site 2 [chemical binding]; other site 771875005671 primosomal protein N' Region: priA; TIGR00595 771875005672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 771875005673 ATP binding site [chemical binding]; other site 771875005674 putative Mg++ binding site [ion binding]; other site 771875005675 PHD zinc finger; Region: PHD; smart00249 771875005676 helicase superfamily c-terminal domain; Region: HELICc; smart00490 771875005677 nucleotide binding region [chemical binding]; other site 771875005678 ATP-binding site [chemical binding]; other site 771875005679 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 771875005680 FAD binding site [chemical binding]; other site 771875005681 GAF domain; Region: GAF_3; pfam13492 771875005682 Predicted membrane protein [Function unknown]; Region: COG4267 771875005683 Putative Fe-S cluster; Region: FeS; pfam04060 771875005684 DNA protecting protein DprA; Region: dprA; TIGR00732 771875005685 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 771875005686 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 771875005687 pantoate--beta-alanine ligase; Region: panC; TIGR00018 771875005688 Pantoate-beta-alanine ligase; Region: PanC; cd00560 771875005689 active site 771875005690 ATP-binding site [chemical binding]; other site 771875005691 pantoate-binding site; other site 771875005692 HXXH motif; other site 771875005693 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 771875005694 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 771875005695 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 771875005696 trimer interface [polypeptide binding]; other site 771875005697 active site 771875005698 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 771875005699 catalytic site [active] 771875005700 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 771875005701 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 771875005702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 771875005703 Walker A/P-loop; other site 771875005704 ATP binding site [chemical binding]; other site 771875005705 Q-loop/lid; other site 771875005706 ABC transporter signature motif; other site 771875005707 Walker B; other site 771875005708 D-loop; other site 771875005709 H-loop/switch region; other site 771875005710 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 771875005711 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 771875005712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 771875005713 Walker A/P-loop; other site 771875005714 ATP binding site [chemical binding]; other site 771875005715 Q-loop/lid; other site 771875005716 ABC transporter signature motif; other site 771875005717 Walker B; other site 771875005718 D-loop; other site 771875005719 H-loop/switch region; other site 771875005720 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 771875005721 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 771875005722 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 771875005723 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 771875005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005725 dimer interface [polypeptide binding]; other site 771875005726 conserved gate region; other site 771875005727 putative PBP binding loops; other site 771875005728 ABC-ATPase subunit interface; other site 771875005729 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 771875005730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 771875005731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 771875005732 dimer interface [polypeptide binding]; other site 771875005733 conserved gate region; other site 771875005734 putative PBP binding loops; other site 771875005735 ABC-ATPase subunit interface; other site 771875005736 Domain of unknown function (DUF377); Region: DUF377; pfam04041 771875005737 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 771875005738 active site 771875005739 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 771875005740 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 771875005741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 771875005742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 771875005743 DNA binding site [nucleotide binding] 771875005744 domain linker motif; other site 771875005745 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 771875005746 dimerization interface [polypeptide binding]; other site 771875005747 ligand binding site [chemical binding]; other site 771875005748 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 771875005749 beta-galactosidase; Region: BGL; TIGR03356 771875005750 Transposase; Region: DEDD_Tnp_IS110; pfam01548 771875005751 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 771875005752 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 771875005753 Interdomain contacts; other site 771875005754 Cytokine receptor motif; other site 771875005755 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 771875005756 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 771875005757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875005758 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 771875005759 TPR motif; other site 771875005760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 771875005761 TPR motif; other site 771875005762 binding surface 771875005763 TPR repeat; Region: TPR_11; pfam13414 771875005764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 771875005765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875005766 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 771875005767 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 771875005768 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 771875005769 Transposase domain (DUF772); Region: DUF772; pfam05598 771875005770 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 771875005771 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 771875005772 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 771875005773 putative metal binding site; other site 771875005774 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 771875005775 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 771875005776 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 771875005777 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 771875005778 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 771875005779 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 771875005780 L-serine binding site [chemical binding]; other site 771875005781 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 771875005782 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 771875005783 urocanate hydratase; Provisional; Region: PRK05414 771875005784 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 771875005785 Repair protein; Region: Repair_PSII; pfam04536 771875005786 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 771875005787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 771875005788 active site 771875005789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875005790 active site 771875005791 motif I; other site 771875005792 motif II; other site 771875005793 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 771875005794 putative active site [active] 771875005795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 771875005796 active site 771875005797 Phosphotransferase enzyme family; Region: APH; pfam01636 771875005798 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 771875005799 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 771875005800 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 771875005801 dimer interface [polypeptide binding]; other site 771875005802 motif 1; other site 771875005803 active site 771875005804 motif 2; other site 771875005805 motif 3; other site 771875005806 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 771875005807 anticodon binding site; other site 771875005808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 771875005809 TPR repeat; Region: TPR_11; pfam13414 771875005810 TPR motif; other site 771875005811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875005812 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 771875005813 active site 771875005814 motif I; other site 771875005815 motif II; other site 771875005816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 771875005817 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 771875005818 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 771875005819 substrate binding site; other site 771875005820 metal-binding site 771875005821 Oligomer interface; other site 771875005822 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 771875005823 glutamine synthetase, type I; Region: GlnA; TIGR00653 771875005824 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 771875005825 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 771875005826 Predicted transcriptional regulators [Transcription]; Region: COG1695 771875005827 Transcriptional regulator PadR-like family; Region: PadR; cl17335 771875005828 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 771875005829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 771875005830 Histidine kinase; Region: His_kinase; pfam06580 771875005831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875005832 ATP binding site [chemical binding]; other site 771875005833 Mg2+ binding site [ion binding]; other site 771875005834 G-X-G motif; other site 771875005835 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 771875005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875005837 active site 771875005838 phosphorylation site [posttranslational modification] 771875005839 intermolecular recognition site; other site 771875005840 dimerization interface [polypeptide binding]; other site 771875005841 LytTr DNA-binding domain; Region: LytTR; smart00850 771875005842 chaperone protein DnaJ; Provisional; Region: PRK14282 771875005843 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 771875005844 HSP70 interaction site [polypeptide binding]; other site 771875005845 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 771875005846 Zn binding sites [ion binding]; other site 771875005847 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 771875005848 dimer interface [polypeptide binding]; other site 771875005849 GrpE; Region: GrpE; pfam01025 771875005850 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 771875005851 dimer interface [polypeptide binding]; other site 771875005852 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 771875005853 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 771875005854 EamA-like transporter family; Region: EamA; pfam00892 771875005855 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 771875005856 EamA-like transporter family; Region: EamA; pfam00892 771875005857 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 771875005858 rRNA interaction site [nucleotide binding]; other site 771875005859 S8 interaction site; other site 771875005860 putative laminin-1 binding site; other site 771875005861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 771875005862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 771875005863 substrate binding pocket [chemical binding]; other site 771875005864 membrane-bound complex binding site; other site 771875005865 hinge residues; other site 771875005866 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875005867 Zn2+ binding site [ion binding]; other site 771875005868 Mg2+ binding site [ion binding]; other site 771875005869 GTP-binding protein Der; Reviewed; Region: PRK00093 771875005870 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 771875005871 G1 box; other site 771875005872 GTP/Mg2+ binding site [chemical binding]; other site 771875005873 Switch I region; other site 771875005874 G2 box; other site 771875005875 Switch II region; other site 771875005876 G3 box; other site 771875005877 G4 box; other site 771875005878 G5 box; other site 771875005879 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 771875005880 G1 box; other site 771875005881 GTP/Mg2+ binding site [chemical binding]; other site 771875005882 Switch I region; other site 771875005883 G2 box; other site 771875005884 G3 box; other site 771875005885 Switch II region; other site 771875005886 G4 box; other site 771875005887 G5 box; other site 771875005888 LytB protein; Region: LYTB; cl00507 771875005889 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 771875005890 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 771875005891 RNA binding site [nucleotide binding]; other site 771875005892 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 771875005893 RNA binding site [nucleotide binding]; other site 771875005894 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 771875005895 RNA binding site [nucleotide binding]; other site 771875005896 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 771875005897 RNA binding site [nucleotide binding]; other site 771875005898 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 771875005899 RNA binding site [nucleotide binding]; other site 771875005900 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 771875005901 RNA binding site [nucleotide binding]; other site 771875005902 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 771875005903 cytidylate kinase; Provisional; Region: cmk; PRK00023 771875005904 CMP-binding site; other site 771875005905 The sites determining sugar specificity; other site 771875005906 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 771875005907 anti sigma factor interaction site; other site 771875005908 regulatory phosphorylation site [posttranslational modification]; other site 771875005909 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 771875005910 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 771875005911 dimer interface [polypeptide binding]; other site 771875005912 anticodon binding site; other site 771875005913 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 771875005914 homodimer interface [polypeptide binding]; other site 771875005915 motif 1; other site 771875005916 active site 771875005917 motif 2; other site 771875005918 GAD domain; Region: GAD; pfam02938 771875005919 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 771875005920 active site 771875005921 motif 3; other site 771875005922 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 771875005923 active site 771875005924 intersubunit interactions; other site 771875005925 catalytic residue [active] 771875005926 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 771875005927 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 771875005928 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 771875005929 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 771875005930 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 771875005931 GatB domain; Region: GatB_Yqey; smart00845 771875005932 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 771875005933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875005934 FeS/SAM binding site; other site 771875005935 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 771875005936 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 771875005937 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 771875005938 active site 771875005939 homodimer interface [polypeptide binding]; other site 771875005940 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 771875005941 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 771875005942 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 771875005943 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 771875005944 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 771875005945 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 771875005946 Walker A/P-loop; other site 771875005947 ATP binding site [chemical binding]; other site 771875005948 Q-loop/lid; other site 771875005949 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 771875005950 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 771875005951 Q-loop/lid; other site 771875005952 ABC transporter signature motif; other site 771875005953 Walker B; other site 771875005954 D-loop; other site 771875005955 H-loop/switch region; other site 771875005956 PAS domain; Region: PAS; smart00091 771875005957 PAS fold; Region: PAS_4; pfam08448 771875005958 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 771875005959 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 771875005960 Uncharacterized conserved protein [Function unknown]; Region: COG1434 771875005961 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 771875005962 putative active site [active] 771875005963 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 771875005964 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 771875005965 active site 771875005966 homotetramer interface [polypeptide binding]; other site 771875005967 homodimer interface [polypeptide binding]; other site 771875005968 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 771875005969 Domain of unknown function DUF20; Region: UPF0118; pfam01594 771875005970 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 771875005971 oligomerization interface [polypeptide binding]; other site 771875005972 active site 771875005973 metal binding site [ion binding]; metal-binding site 771875005974 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 771875005975 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 771875005976 active site 771875005977 Zn binding site [ion binding]; other site 771875005978 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 771875005979 active site 771875005980 catalytic residues [active] 771875005981 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 771875005982 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 771875005983 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 771875005984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875005985 ATP binding site [chemical binding]; other site 771875005986 Mg2+ binding site [ion binding]; other site 771875005987 G-X-G motif; other site 771875005988 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 771875005989 ATP binding site [chemical binding]; other site 771875005990 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 771875005991 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 771875005992 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 771875005993 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 771875005994 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 771875005995 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 771875005996 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 771875005997 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 771875005998 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 771875005999 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 771875006000 16S/18S rRNA binding site [nucleotide binding]; other site 771875006001 S13e-L30e interaction site [polypeptide binding]; other site 771875006002 25S rRNA binding site [nucleotide binding]; other site 771875006003 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 771875006004 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 771875006005 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 771875006006 active site 771875006007 putative DNA-binding cleft [nucleotide binding]; other site 771875006008 dimer interface [polypeptide binding]; other site 771875006009 DNA polymerase III PolC; Validated; Region: polC; PRK00448 771875006010 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 771875006011 generic binding surface II; other site 771875006012 generic binding surface I; other site 771875006013 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 771875006014 active site 771875006015 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 771875006016 active site 771875006017 catalytic site [active] 771875006018 substrate binding site [chemical binding]; other site 771875006019 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 771875006020 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 771875006021 Preprotein translocase SecG subunit; Region: SecG; pfam03840 771875006022 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 771875006023 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 771875006024 active site 771875006025 HIGH motif; other site 771875006026 dimer interface [polypeptide binding]; other site 771875006027 KMSKS motif; other site 771875006028 S-layer homology domain; Region: SLH; pfam00395 771875006029 enolase; Provisional; Region: eno; PRK00077 771875006030 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 771875006031 dimer interface [polypeptide binding]; other site 771875006032 metal binding site [ion binding]; metal-binding site 771875006033 substrate binding pocket [chemical binding]; other site 771875006034 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 771875006035 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 771875006036 Ca binding site [ion binding]; other site 771875006037 active site 771875006038 catalytic site [active] 771875006039 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 771875006040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 771875006041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 771875006042 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 771875006043 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 771875006044 active site 771875006045 DNA binding site [nucleotide binding] 771875006046 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 771875006047 Predicted integral membrane protein [Function unknown]; Region: COG5652 771875006048 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 771875006049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 771875006050 substrate binding pocket [chemical binding]; other site 771875006051 membrane-bound complex binding site; other site 771875006052 hinge residues; other site 771875006053 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 771875006054 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 771875006055 substrate binding pocket [chemical binding]; other site 771875006056 membrane-bound complex binding site; other site 771875006057 hinge residues; other site 771875006058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 771875006059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875006060 ATP binding site [chemical binding]; other site 771875006061 Mg2+ binding site [ion binding]; other site 771875006062 G-X-G motif; other site 771875006063 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 771875006064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875006065 active site 771875006066 phosphorylation site [posttranslational modification] 771875006067 intermolecular recognition site; other site 771875006068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 771875006069 Zn2+ binding site [ion binding]; other site 771875006070 Mg2+ binding site [ion binding]; other site 771875006071 Helix-hairpin-helix motif; Region: HHH; pfam00633 771875006072 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 771875006073 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 771875006074 Helix-hairpin-helix motif; Region: HHH; pfam00633 771875006075 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 771875006076 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 771875006077 oligomer interface [polypeptide binding]; other site 771875006078 active site 771875006079 metal binding site [ion binding]; metal-binding site 771875006080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875006081 Radical SAM superfamily; Region: Radical_SAM; pfam04055 771875006082 FeS/SAM binding site; other site 771875006083 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 771875006084 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469 771875006085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 771875006086 FeS/SAM binding site; other site 771875006087 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 771875006088 PASTA domain; Region: PASTA; smart00740 771875006089 GTPase RsgA; Reviewed; Region: PRK00098 771875006090 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 771875006091 RNA binding site [nucleotide binding]; other site 771875006092 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 771875006093 GTPase/Zn-binding domain interface [polypeptide binding]; other site 771875006094 GTP/Mg2+ binding site [chemical binding]; other site 771875006095 G4 box; other site 771875006096 G5 box; other site 771875006097 G1 box; other site 771875006098 Switch I region; other site 771875006099 G2 box; other site 771875006100 G3 box; other site 771875006101 Switch II region; other site 771875006102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 771875006103 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 771875006104 putative ADP-binding pocket [chemical binding]; other site 771875006105 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 771875006106 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 771875006107 C-terminal peptidase (prc); Region: prc; TIGR00225 771875006108 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 771875006109 protein binding site [polypeptide binding]; other site 771875006110 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 771875006111 Catalytic dyad [active] 771875006112 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 771875006113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875006114 S-adenosylmethionine binding site [chemical binding]; other site 771875006115 Uncharacterized conserved protein [Function unknown]; Region: AMMECR1; COG2078 771875006116 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 771875006117 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 771875006118 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 771875006119 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 771875006120 TrkA-N domain; Region: TrkA_N; pfam02254 771875006121 TrkA-C domain; Region: TrkA_C; pfam02080 771875006122 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 771875006123 TrkA-N domain; Region: TrkA_N; pfam02254 771875006124 Response regulator receiver domain; Region: Response_reg; pfam00072 771875006125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 771875006126 active site 771875006127 phosphorylation site [posttranslational modification] 771875006128 intermolecular recognition site; other site 771875006129 dimerization interface [polypeptide binding]; other site 771875006130 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 771875006131 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 771875006132 active site 771875006133 catalytic site [active] 771875006134 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 771875006135 putative ligand binding site [chemical binding]; other site 771875006136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 771875006137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 771875006138 ATP binding site [chemical binding]; other site 771875006139 Mg2+ binding site [ion binding]; other site 771875006140 G-X-G motif; other site 771875006141 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 771875006142 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 771875006143 dimer interface [polypeptide binding]; other site 771875006144 active site 771875006145 metal binding site [ion binding]; metal-binding site 771875006146 transketolase; Reviewed; Region: PRK05899 771875006147 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 771875006148 TPP-binding site [chemical binding]; other site 771875006149 dimer interface [polypeptide binding]; other site 771875006150 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 771875006151 PYR/PP interface [polypeptide binding]; other site 771875006152 dimer interface [polypeptide binding]; other site 771875006153 TPP binding site [chemical binding]; other site 771875006154 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 771875006155 hypothetical protein; Provisional; Region: PRK11820 771875006156 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 771875006157 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 771875006158 hypothetical protein; Provisional; Region: PRK04323 771875006159 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 771875006160 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 771875006161 catalytic site [active] 771875006162 G-X2-G-X-G-K; other site 771875006163 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 771875006164 amidophosphoribosyltransferase; Region: purF; TIGR01134 771875006165 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 771875006166 active site 771875006167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875006168 active site 771875006169 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 771875006170 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 771875006171 active site 771875006172 substrate binding site [chemical binding]; other site 771875006173 cosubstrate binding site; other site 771875006174 catalytic site [active] 771875006175 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 771875006176 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 771875006177 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 771875006178 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 771875006179 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 771875006180 ATP-grasp domain; Region: ATP-grasp_4; cl17255 771875006181 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 771875006182 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 771875006183 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 771875006184 dimerization interface [polypeptide binding]; other site 771875006185 ATP binding site [chemical binding]; other site 771875006186 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 771875006187 MutL protein; Region: MutL; pfam13941 771875006188 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 771875006189 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 771875006190 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 771875006191 AAA domain; Region: AAA_32; pfam13654 771875006192 ATP-dependent protease Lon; Provisional; Region: PRK13765 771875006193 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 771875006194 6-phosphofructokinase; Provisional; Region: PRK03202 771875006195 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 771875006196 active site 771875006197 ADP/pyrophosphate binding site [chemical binding]; other site 771875006198 dimerization interface [polypeptide binding]; other site 771875006199 allosteric effector site; other site 771875006200 fructose-1,6-bisphosphate binding site; other site 771875006201 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 771875006202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 771875006203 active site 771875006204 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 771875006205 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 771875006206 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 771875006207 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 771875006208 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 771875006209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 771875006210 Peptidase family M23; Region: Peptidase_M23; pfam01551 771875006211 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 771875006212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875006213 S-adenosylmethionine binding site [chemical binding]; other site 771875006214 Protein of unknown function (DUF501); Region: DUF501; pfam04417 771875006215 LabA_like proteins; Region: LabA_like; cd06167 771875006216 putative metal binding site [ion binding]; other site 771875006217 Uncharacterized conserved protein [Function unknown]; Region: COG1432 771875006218 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 771875006219 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 771875006220 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 771875006221 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 771875006222 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 771875006223 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 771875006224 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 771875006225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 771875006226 S-adenosylmethionine binding site [chemical binding]; other site 771875006227 adenylosuccinate lyase; Provisional; Region: PRK07492 771875006228 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 771875006229 tetramer interface [polypeptide binding]; other site 771875006230 active site 771875006231 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 771875006232 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 771875006233 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 771875006234 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 771875006235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 771875006236 catalytic residue [active] 771875006237 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 771875006238 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 771875006239 B12 binding site [chemical binding]; other site 771875006240 cobalt ligand [ion binding]; other site 771875006241 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 771875006242 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 771875006243 Glutamate binding site [chemical binding]; other site 771875006244 homodimer interface [polypeptide binding]; other site 771875006245 NAD binding site [chemical binding]; other site 771875006246 catalytic residues [active] 771875006247 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 771875006248 Staphylococcal nuclease homologues; Region: SNc; smart00318 771875006249 Catalytic site; other site 771875006250 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 771875006251 generic binding surface I; other site 771875006252 generic binding surface II; other site 771875006253 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 771875006254 generic binding surface I; other site 771875006255 generic binding surface II; other site 771875006256 Staphylococcal nuclease homologues; Region: SNc; smart00318 771875006257 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 771875006258 Catalytic site; other site 771875006259 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 771875006260 Alkaline phosphatase homologues; Region: alkPPc; smart00098 771875006261 active site 771875006262 dimer interface [polypeptide binding]; other site 771875006263 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 771875006264 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 771875006265 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 771875006266 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 771875006267 active site 771875006268 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 771875006269 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 771875006270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 771875006271 ABC transporter signature motif; other site 771875006272 Walker B; other site 771875006273 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 771875006274 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 771875006275 minor groove reading motif; other site 771875006276 helix-hairpin-helix signature motif; other site 771875006277 substrate binding pocket [chemical binding]; other site 771875006278 active site 771875006279 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 771875006280 diiron binding motif [ion binding]; other site 771875006281 putative oxidoreductase; Provisional; Region: PRK13984 771875006282 4Fe-4S binding domain; Region: Fer4; pfam00037 771875006283 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 771875006284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 771875006285 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 771875006286 NADH dehydrogenase subunit D; Validated; Region: PRK06075 771875006287 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 771875006288 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 771875006289 NADH dehydrogenase subunit B; Validated; Region: PRK06411 771875006290 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 771875006291 NADH dehydrogenase; Region: NADHdh; cl00469 771875006292 NADH dehydrogenase subunit M; Validated; Region: PRK08668 771875006293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 771875006294 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 771875006295 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 771875006296 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 771875006297 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 771875006298 hypothetical protein; Provisional; Region: PRK08378 771875006299 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 771875006300 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 771875006301 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 771875006302 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 771875006303 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 771875006304 predicted active site [active] 771875006305 catalytic triad [active] 771875006306 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 771875006307 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 771875006308 active site 771875006309 multimer interface [polypeptide binding]; other site 771875006310 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 771875006311 Flagellar protein FliT; Region: FliT; cl05125 771875006312 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 771875006313 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 771875006314 catalytic center binding site [active] 771875006315 ATP binding site [chemical binding]; other site 771875006316 oxaloacetate decarboxylase; Provisional; Region: PRK14041 771875006317 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 771875006318 active site 771875006319 catalytic residues [active] 771875006320 metal binding site [ion binding]; metal-binding site 771875006321 homodimer binding site [polypeptide binding]; other site 771875006322 hypothetical protein; Provisional; Region: PRK13670 771875006323 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 771875006324 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 771875006325 DEAD-like helicases superfamily; Region: DEXDc; smart00487 771875006326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 771875006327 ATP binding site [chemical binding]; other site 771875006328 putative Mg++ binding site [ion binding]; other site 771875006329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 771875006330 nucleotide binding region [chemical binding]; other site 771875006331 ATP-binding site [chemical binding]; other site 771875006332 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 771875006333 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 771875006334 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 771875006335 peptide chain release factor 2; Validated; Region: prfB; PRK00578 771875006336 This domain is found in peptide chain release factors; Region: PCRF; smart00937 771875006337 RF-1 domain; Region: RF-1; pfam00472 771875006338 septum site-determining protein MinD; Region: minD_bact; TIGR01968 771875006339 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 771875006340 Switch I; other site 771875006341 Switch II; other site 771875006342 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 771875006343 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 771875006344 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 771875006345 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 771875006346 P loop; other site 771875006347 GTP binding site [chemical binding]; other site 771875006348 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 771875006349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 771875006350 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 771875006351 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 771875006352 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 771875006353 Peptidase family M23; Region: Peptidase_M23; pfam01551 771875006354 3D domain; Region: 3D; cl01439 771875006355 Rrf2 family protein; Region: rrf2_super; TIGR00738 771875006356 Transcriptional regulator; Region: Rrf2; pfam02082 771875006357 Transcriptional regulator; Region: Rrf2; cl17282 771875006358 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 771875006359 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 771875006360 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 771875006361 active site 771875006362 Transcriptional regulator [Transcription]; Region: LytR; COG1316 771875006363 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 771875006364 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 771875006365 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 771875006366 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 771875006367 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 771875006368 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 771875006369 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 771875006370 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 771875006371 active site 771875006372 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 771875006373 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 771875006374 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 771875006375 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 771875006376 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 771875006377 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 771875006378 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 771875006379 G-loop; other site 771875006380 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 771875006381 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 771875006382 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 771875006383 DNA binding site [nucleotide binding] 771875006384 clamp; other site 771875006385 Rpb1 - Rpb2 interaction site [polypeptide binding]; other site 771875006386 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 771875006387 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 771875006388 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 771875006389 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 771875006390 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 771875006391 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 771875006392 RPB10 interaction site [polypeptide binding]; other site 771875006393 RPB1 interaction site [polypeptide binding]; other site 771875006394 RPB11 interaction site [polypeptide binding]; other site 771875006395 RPB3 interaction site [polypeptide binding]; other site 771875006396 RPB12 interaction site [polypeptide binding]; other site 771875006397 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 771875006398 core dimer interface [polypeptide binding]; other site 771875006399 peripheral dimer interface [polypeptide binding]; other site 771875006400 L10 interface [polypeptide binding]; other site 771875006401 L11 interface [polypeptide binding]; other site 771875006402 putative EF-Tu interaction site [polypeptide binding]; other site 771875006403 putative EF-G interaction site [polypeptide binding]; other site 771875006404 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 771875006405 23S rRNA interface [nucleotide binding]; other site 771875006406 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 771875006407 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 771875006408 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 771875006409 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 771875006410 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 771875006411 MraW methylase family; Region: Methyltransf_5; cl17771 771875006412 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 771875006413 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 771875006414 putative substrate binding site [chemical binding]; other site 771875006415 nucleotide binding site [chemical binding]; other site 771875006416 nucleotide binding site [chemical binding]; other site 771875006417 homodimer interface [polypeptide binding]; other site 771875006418 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 771875006419 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 771875006420 SxDxEG motif; other site 771875006421 putative active site [active] 771875006422 putative metal binding site [ion binding]; other site