-- dump date   	20140619_093506
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
59374000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
59374000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
59374000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374000004	Walker A motif; other site
59374000005	ATP binding site [chemical binding]; other site
59374000006	Walker B motif; other site
59374000007	arginine finger; other site
59374000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
59374000009	DnaA box-binding interface [nucleotide binding]; other site
59374000010	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
59374000011	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
59374000012	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
59374000013	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
59374000014	Protein export membrane protein; Region: SecD_SecF; cl14618
59374000015	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
59374000016	trimer interface [polypeptide binding]; other site
59374000017	active site
59374000018	Peptidase family C25; Region: Peptidase_C25; pfam01364
59374000019	active site
59374000020	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
59374000021	RF-1 domain; Region: RF-1; cl17422
59374000022	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
59374000023	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
59374000024	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
59374000025	G1 box; other site
59374000026	putative GEF interaction site [polypeptide binding]; other site
59374000027	GTP/Mg2+ binding site [chemical binding]; other site
59374000028	Switch I region; other site
59374000029	G2 box; other site
59374000030	G3 box; other site
59374000031	Switch II region; other site
59374000032	G4 box; other site
59374000033	G5 box; other site
59374000034	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
59374000035	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
59374000036	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
59374000037	substrate binding site [chemical binding]; other site
59374000038	dimer interface [polypeptide binding]; other site
59374000039	ATP binding site [chemical binding]; other site
59374000040	MgtC family; Region: MgtC; pfam02308
59374000041	Predicted membrane protein [Function unknown]; Region: COG3174
59374000042	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
59374000043	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374000044	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374000045	metal binding site [ion binding]; metal-binding site
59374000046	active site
59374000047	I-site; other site
59374000048	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
59374000049	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
59374000050	folate binding site [chemical binding]; other site
59374000051	NADP+ binding site [chemical binding]; other site
59374000052	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
59374000053	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
59374000054	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
59374000055	active site
59374000056	metal binding site [ion binding]; metal-binding site
59374000057	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
59374000058	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374000059	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
59374000060	tetramer (dimer of dimers) interface [polypeptide binding]; other site
59374000061	active site
59374000062	dimer interface [polypeptide binding]; other site
59374000063	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
59374000064	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
59374000065	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374000066	Zn2+ binding site [ion binding]; other site
59374000067	Mg2+ binding site [ion binding]; other site
59374000068	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374000069	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374000070	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374000071	RelB antitoxin; Region: RelB; cl01171
59374000072	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
59374000073	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
59374000074	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
59374000075	Peptidase family U32; Region: Peptidase_U32; pfam01136
59374000076	Collagenase; Region: DUF3656; pfam12392
59374000077	Peptidase family U32; Region: Peptidase_U32; cl03113
59374000078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374000079	binding surface
59374000080	TPR motif; other site
59374000081	TPR repeat; Region: TPR_11; pfam13414
59374000082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374000083	binding surface
59374000084	TPR repeat; Region: TPR_11; pfam13414
59374000085	TPR motif; other site
59374000086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374000087	binding surface
59374000088	TPR motif; other site
59374000089	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
59374000090	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
59374000091	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
59374000092	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
59374000093	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
59374000094	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
59374000095	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
59374000096	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
59374000097	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
59374000098	active site
59374000099	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
59374000100	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
59374000101	active site
59374000102	(T/H)XGH motif; other site
59374000103	ribosome small subunit-dependent GTPase A; Region: TIGR00157
59374000104	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
59374000105	GTPase/Zn-binding domain interface [polypeptide binding]; other site
59374000106	GTP/Mg2+ binding site [chemical binding]; other site
59374000107	G4 box; other site
59374000108	G5 box; other site
59374000109	G1 box; other site
59374000110	Switch I region; other site
59374000111	G2 box; other site
59374000112	G3 box; other site
59374000113	Switch II region; other site
59374000114	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
59374000115	UbiA prenyltransferase family; Region: UbiA; pfam01040
59374000116	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
59374000117	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
59374000118	active site
59374000119	tetramer interface [polypeptide binding]; other site
59374000120	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374000121	active site
59374000122	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59374000123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374000124	NAD(P) binding site [chemical binding]; other site
59374000125	active site
59374000126	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
59374000127	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
59374000128	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374000129	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
59374000130	Glycoprotease family; Region: Peptidase_M22; pfam00814
59374000131	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
59374000132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374000133	Coenzyme A binding pocket [chemical binding]; other site
59374000134	DUF218 domain; Region: DUF218; pfam02698
59374000135	putative active site [active]
59374000136	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
59374000137	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374000138	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
59374000139	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
59374000140	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
59374000141	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
59374000142	active site
59374000143	Substrate binding site; other site
59374000144	Mg++ binding site; other site
59374000145	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
59374000146	putative CoA binding site [chemical binding]; other site
59374000147	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
59374000148	oligomerisation interface [polypeptide binding]; other site
59374000149	mobile loop; other site
59374000150	roof hairpin; other site
59374000151	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
59374000152	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
59374000153	ring oligomerisation interface [polypeptide binding]; other site
59374000154	ATP/Mg binding site [chemical binding]; other site
59374000155	stacking interactions; other site
59374000156	hinge regions; other site
59374000157	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
59374000158	Transglycosylase; Region: Transgly; pfam00912
59374000159	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
59374000160	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
59374000161	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374000162	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
59374000163	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
59374000164	substrate binding site [chemical binding]; other site
59374000165	ligand binding site [chemical binding]; other site
59374000166	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
59374000167	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
59374000168	substrate binding site [chemical binding]; other site
59374000169	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
59374000170	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374000171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374000172	non-specific DNA binding site [nucleotide binding]; other site
59374000173	salt bridge; other site
59374000174	sequence-specific DNA binding site [nucleotide binding]; other site
59374000175	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
59374000176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
59374000177	TPR motif; other site
59374000178	binding surface
59374000179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
59374000180	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374000181	Coenzyme A binding pocket [chemical binding]; other site
59374000182	Bacterial PH domain; Region: DUF304; pfam03703
59374000183	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
59374000184	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
59374000185	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
59374000186	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
59374000187	active site
59374000188	NYN domain; Region: NYN; pfam01936
59374000189	Uncharacterized conserved protein [Function unknown]; Region: COG1432
59374000190	putative metal binding site [ion binding]; other site
59374000191	OST-HTH/LOTUS domain; Region: OST-HTH; pfam12872
59374000192	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
59374000193	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
59374000194	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374000195	metal ion-dependent adhesion site (MIDAS); other site
59374000196	Protein phosphatase 2C; Region: PP2C_2; pfam13672
59374000197	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
59374000198	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374000199	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
59374000200	active site
59374000201	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
59374000202	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
59374000203	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
59374000204	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59374000205	inhibitor-cofactor binding pocket; inhibition site
59374000206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000207	catalytic residue [active]
59374000208	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374000209	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
59374000210	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
59374000211	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
59374000212	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
59374000213	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
59374000214	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59374000215	catalytic residues [active]
59374000216	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
59374000217	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
59374000218	phosphate binding site [ion binding]; other site
59374000219	hypothetical protein; Provisional; Region: PRK07907
59374000220	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
59374000221	active site
59374000222	metal binding site [ion binding]; metal-binding site
59374000223	dimer interface [polypeptide binding]; other site
59374000224	NAD-dependent deacetylase; Provisional; Region: PRK00481
59374000225	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
59374000226	NAD+ binding site [chemical binding]; other site
59374000227	substrate binding site [chemical binding]; other site
59374000228	Zn binding site [ion binding]; other site
59374000229	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000230	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
59374000231	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
59374000232	Walker A/P-loop; other site
59374000233	ATP binding site [chemical binding]; other site
59374000234	Q-loop/lid; other site
59374000235	ABC transporter signature motif; other site
59374000236	Walker B; other site
59374000237	D-loop; other site
59374000238	H-loop/switch region; other site
59374000239	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
59374000240	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
59374000241	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374000242	dimer interface [polypeptide binding]; other site
59374000243	conserved gate region; other site
59374000244	putative PBP binding loops; other site
59374000245	ABC-ATPase subunit interface; other site
59374000246	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
59374000247	radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133
59374000248	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374000249	FeS/SAM binding site; other site
59374000250	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
59374000251	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
59374000252	The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921
59374000253	aspartate aminotransferase; Provisional; Region: PRK05764
59374000254	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374000255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000256	homodimer interface [polypeptide binding]; other site
59374000257	catalytic residue [active]
59374000258	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
59374000259	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
59374000260	phosphopeptide binding site; other site
59374000261	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
59374000262	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
59374000263	Walker A/P-loop; other site
59374000264	ATP binding site [chemical binding]; other site
59374000265	Q-loop/lid; other site
59374000266	ABC transporter signature motif; other site
59374000267	Walker B; other site
59374000268	D-loop; other site
59374000269	H-loop/switch region; other site
59374000270	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
59374000271	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
59374000272	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
59374000273	Catalytic domain of Protein Kinases; Region: PKc; cd00180
59374000274	active site
59374000275	ATP binding site [chemical binding]; other site
59374000276	substrate binding site [chemical binding]; other site
59374000277	activation loop (A-loop); other site
59374000278	hypothetical protein; Reviewed; Region: PRK12497
59374000279	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
59374000280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374000281	TPR motif; other site
59374000282	binding surface
59374000283	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
59374000284	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
59374000285	active site
59374000286	metal binding site [ion binding]; metal-binding site
59374000287	homotetramer interface [polypeptide binding]; other site
59374000288	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
59374000289	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
59374000290	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374000291	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374000292	metal binding site [ion binding]; metal-binding site
59374000293	active site
59374000294	I-site; other site
59374000295	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
59374000296	Domain of unknown function DUF; Region: DUF204; pfam02659
59374000297	Domain of unknown function DUF; Region: DUF204; pfam02659
59374000298	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
59374000299	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
59374000300	nucleotide binding pocket [chemical binding]; other site
59374000301	K-X-D-G motif; other site
59374000302	catalytic site [active]
59374000303	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
59374000304	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
59374000305	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
59374000306	Dimer interface [polypeptide binding]; other site
59374000307	BRCT sequence motif; other site
59374000308	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000309	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
59374000310	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
59374000311	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
59374000312	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
59374000313	RmuC family; Region: RmuC; pfam02646
59374000314	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
59374000315	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
59374000316	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
59374000317	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
59374000318	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
59374000319	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
59374000320	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
59374000321	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
59374000322	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
59374000323	Protein phosphatase 2C; Region: PP2C_2; pfam13672
59374000324	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374000325	metal ion-dependent adhesion site (MIDAS); other site
59374000326	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
59374000327	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
59374000328	active site
59374000329	ATP binding site [chemical binding]; other site
59374000330	substrate binding site [chemical binding]; other site
59374000331	activation loop (A-loop); other site
59374000332	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
59374000333	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
59374000334	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
59374000335	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607
59374000336	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
59374000337	glutamine binding [chemical binding]; other site
59374000338	catalytic triad [active]
59374000339	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
59374000340	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
59374000341	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374000342	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
59374000343	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
59374000344	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
59374000345	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
59374000346	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
59374000347	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
59374000348	4Fe-4S binding domain; Region: Fer4; pfam00037
59374000349	4Fe-4S binding domain; Region: Fer4; pfam00037
59374000350	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
59374000351	L-aspartate oxidase; Provisional; Region: PRK06175
59374000352	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
59374000353	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
59374000354	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
59374000355	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
59374000356	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
59374000357	Active Sites [active]
59374000358	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
59374000359	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
59374000360	CysD dimerization site [polypeptide binding]; other site
59374000361	G1 box; other site
59374000362	putative GEF interaction site [polypeptide binding]; other site
59374000363	GTP/Mg2+ binding site [chemical binding]; other site
59374000364	Switch I region; other site
59374000365	G2 box; other site
59374000366	G3 box; other site
59374000367	Switch II region; other site
59374000368	G4 box; other site
59374000369	G5 box; other site
59374000370	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
59374000371	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
59374000372	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374000373	substrate binding pocket [chemical binding]; other site
59374000374	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
59374000375	membrane-bound complex binding site; other site
59374000376	hinge residues; other site
59374000377	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
59374000378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374000379	dimer interface [polypeptide binding]; other site
59374000380	conserved gate region; other site
59374000381	putative PBP binding loops; other site
59374000382	ABC-ATPase subunit interface; other site
59374000383	sulfate transport protein; Provisional; Region: cysT; CHL00187
59374000384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374000385	dimer interface [polypeptide binding]; other site
59374000386	conserved gate region; other site
59374000387	putative PBP binding loops; other site
59374000388	ABC-ATPase subunit interface; other site
59374000389	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
59374000390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374000391	Walker A/P-loop; other site
59374000392	ATP binding site [chemical binding]; other site
59374000393	Q-loop/lid; other site
59374000394	ABC transporter signature motif; other site
59374000395	Walker B; other site
59374000396	D-loop; other site
59374000397	H-loop/switch region; other site
59374000398	TOBE domain; Region: TOBE_2; pfam08402
59374000399	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
59374000400	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
59374000401	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59374000402	homodimer interface [polypeptide binding]; other site
59374000403	substrate-cofactor binding pocket; other site
59374000404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000405	catalytic residue [active]
59374000406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59374000407	Cupin domain; Region: Cupin_2; pfam07883
59374000408	biotin synthase; Region: bioB; TIGR00433
59374000409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374000410	FeS/SAM binding site; other site
59374000411	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
59374000412	LysE type translocator; Region: LysE; cl00565
59374000413	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
59374000414	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
59374000415	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
59374000416	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59374000417	homodimer interface [polypeptide binding]; other site
59374000418	substrate-cofactor binding pocket; other site
59374000419	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000420	catalytic residue [active]
59374000421	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
59374000422	CPxP  motif; other site
59374000423	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
59374000424	thiS-thiF/thiG interaction site; other site
59374000425	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
59374000426	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
59374000427	ATP binding site [chemical binding]; other site
59374000428	substrate interface [chemical binding]; other site
59374000429	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
59374000430	MPN+ (JAMM) motif; other site
59374000431	Zinc-binding site [ion binding]; other site
59374000432	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
59374000433	MPN+ (JAMM) motif; other site
59374000434	Zinc-binding site [ion binding]; other site
59374000435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
59374000436	Ubiquitin-like proteins; Region: UBQ; cl00155
59374000437	charged pocket; other site
59374000438	hydrophobic patch; other site
59374000439	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
59374000440	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
59374000441	ATP binding site [chemical binding]; other site
59374000442	substrate interface [chemical binding]; other site
59374000443	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
59374000444	active site residue [active]
59374000445	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
59374000446	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
59374000447	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374000448	catalytic residue [active]
59374000449	serine O-acetyltransferase; Region: cysE; TIGR01172
59374000450	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
59374000451	trimer interface [polypeptide binding]; other site
59374000452	active site
59374000453	substrate binding site [chemical binding]; other site
59374000454	CoA binding site [chemical binding]; other site
59374000455	Amb_all domain; Region: Amb_all; smart00656
59374000456	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
59374000457	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
59374000458	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
59374000459	active site
59374000460	ribulose/triose binding site [chemical binding]; other site
59374000461	phosphate binding site [ion binding]; other site
59374000462	substrate (anthranilate) binding pocket [chemical binding]; other site
59374000463	product (indole) binding pocket [chemical binding]; other site
59374000464	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
59374000465	active site
59374000466	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
59374000467	DHH family; Region: DHH; pfam01368
59374000468	DHHA2 domain; Region: DHHA2; pfam02833
59374000469	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
59374000470	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
59374000471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000472	catalytic residue [active]
59374000473	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
59374000474	substrate binding site [chemical binding]; other site
59374000475	active site
59374000476	catalytic residues [active]
59374000477	heterodimer interface [polypeptide binding]; other site
59374000478	aconitate hydratase; Validated; Region: PRK07229
59374000479	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
59374000480	substrate binding site [chemical binding]; other site
59374000481	ligand binding site [chemical binding]; other site
59374000482	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
59374000483	substrate binding site [chemical binding]; other site
59374000484	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374000485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374000486	metal binding site [ion binding]; metal-binding site
59374000487	active site
59374000488	I-site; other site
59374000489	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
59374000490	Na binding site [ion binding]; other site
59374000491	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
59374000492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59374000493	putative substrate translocation pore; other site
59374000494	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59374000495	putative acyl-acceptor binding pocket; other site
59374000496	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374000497	acyl-activating enzyme (AAE) consensus motif; other site
59374000498	AMP binding site [chemical binding]; other site
59374000499	active site
59374000500	CoA binding site [chemical binding]; other site
59374000501	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
59374000502	homotrimer interaction site [polypeptide binding]; other site
59374000503	putative active site [active]
59374000504	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
59374000505	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
59374000506	MutS domain I; Region: MutS_I; pfam01624
59374000507	MutS domain II; Region: MutS_II; pfam05188
59374000508	MutS domain III; Region: MutS_III; pfam05192
59374000509	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
59374000510	Walker A/P-loop; other site
59374000511	ATP binding site [chemical binding]; other site
59374000512	Q-loop/lid; other site
59374000513	ABC transporter signature motif; other site
59374000514	Walker B; other site
59374000515	D-loop; other site
59374000516	H-loop/switch region; other site
59374000517	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
59374000518	gamma-glutamyl kinase; Provisional; Region: PRK05429
59374000519	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
59374000520	nucleotide binding site [chemical binding]; other site
59374000521	homotetrameric interface [polypeptide binding]; other site
59374000522	putative phosphate binding site [ion binding]; other site
59374000523	putative allosteric binding site; other site
59374000524	PUA domain; Region: PUA; pfam01472
59374000525	ATP-dependent helicase HepA; Validated; Region: PRK04914
59374000526	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374000527	ATP binding site [chemical binding]; other site
59374000528	putative Mg++ binding site [ion binding]; other site
59374000529	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374000530	nucleotide binding region [chemical binding]; other site
59374000531	ATP-binding site [chemical binding]; other site
59374000532	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
59374000533	RDD family; Region: RDD; pfam06271
59374000534	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
59374000535	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
59374000536	hinge; other site
59374000537	active site
59374000538	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
59374000539	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
59374000540	Walker A/P-loop; other site
59374000541	ATP binding site [chemical binding]; other site
59374000542	Q-loop/lid; other site
59374000543	ABC transporter signature motif; other site
59374000544	Walker B; other site
59374000545	D-loop; other site
59374000546	H-loop/switch region; other site
59374000547	FecCD transport family; Region: FecCD; pfam01032
59374000548	dimer interface [polypeptide binding]; other site
59374000549	putative PBP binding regions; other site
59374000550	ABC-ATPase subunit  interface; other site
59374000551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
59374000552	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374000553	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374000554	ligand binding site [chemical binding]; other site
59374000555	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
59374000556	TolB amino-terminal domain; Region: TolB_N; pfam04052
59374000557	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
59374000558	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
59374000559	TonB C terminal; Region: TonB_2; pfam13103
59374000560	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
59374000561	TolR protein; Region: tolR; TIGR02801
59374000562	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
59374000563	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
59374000564	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59374000565	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59374000566	Endonuclease I; Region: Endonuclease_1; pfam04231
59374000567	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
59374000568	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
59374000569	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59374000570	RNA binding surface [nucleotide binding]; other site
59374000571	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
59374000572	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
59374000573	DNA-binding site [nucleotide binding]; DNA binding site
59374000574	Transcriptional regulators [Transcription]; Region: PurR; COG1609
59374000575	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
59374000576	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000577	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
59374000578	ATP binding site [chemical binding]; other site
59374000579	active site
59374000580	substrate binding site [chemical binding]; other site
59374000581	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
59374000582	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
59374000583	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
59374000584	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
59374000585	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
59374000586	radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133
59374000587	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374000588	FeS/SAM binding site; other site
59374000589	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
59374000590	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
59374000591	Surface antigen; Region: Bac_surface_Ag; pfam01103
59374000592	cell surface protein SprA; Region: surface_SprA; TIGR04189
59374000593	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
59374000594	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
59374000595	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
59374000596	G1 box; other site
59374000597	GTP/Mg2+ binding site [chemical binding]; other site
59374000598	G2 box; other site
59374000599	Switch I region; other site
59374000600	G3 box; other site
59374000601	Switch II region; other site
59374000602	G4 box; other site
59374000603	G5 box; other site
59374000604	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
59374000605	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
59374000606	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59374000607	inhibitor-cofactor binding pocket; inhibition site
59374000608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000609	catalytic residue [active]
59374000610	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
59374000611	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
59374000612	DHH family; Region: DHH; pfam01368
59374000613	DHHA1 domain; Region: DHHA1; pfam02272
59374000614	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
59374000615	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
59374000616	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
59374000617	Mg++ binding site [ion binding]; other site
59374000618	putative catalytic motif [active]
59374000619	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374000620	active site
59374000621	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
59374000622	putative acyl-acceptor binding pocket; other site
59374000623	Smr domain; Region: Smr; pfam01713
59374000624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
59374000625	FeS/SAM binding site; other site
59374000626	Radical SAM superfamily; Region: Radical_SAM; pfam04055
59374000627	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
59374000628	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
59374000629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
59374000630	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000631	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
59374000632	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
59374000633	dimer interface [polypeptide binding]; other site
59374000634	active site
59374000635	metal binding site [ion binding]; metal-binding site
59374000636	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
59374000637	heterotetramer interface [polypeptide binding]; other site
59374000638	active site pocket [active]
59374000639	cleavage site
59374000640	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
59374000641	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
59374000642	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
59374000643	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
59374000644	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
59374000645	Secretin and TonB N terminus short domain; Region: STN; pfam07660
59374000646	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
59374000647	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
59374000648	Pilus assembly protein, PilP; Region: PilP; pfam04351
59374000649	Pilus assembly protein, PilO; Region: PilO; cl01234
59374000650	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
59374000651	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
59374000652	Competence protein A; Region: Competence_A; pfam11104
59374000653	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
59374000654	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
59374000655	PilZ domain; Region: PilZ; pfam07238
59374000656	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
59374000657	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
59374000658	active site
59374000659	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
59374000660	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
59374000661	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
59374000662	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
59374000663	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374000664	active site
59374000665	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
59374000666	active site
59374000667	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374000668	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374000669	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
59374000670	putative active site [active]
59374000671	putative Zn binding site [ion binding]; other site
59374000672	Bacitracin resistance protein BacA; Region: BacA; pfam02673
59374000673	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
59374000674	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
59374000675	DNA methylase; Region: N6_N4_Mtase; cl17433
59374000676	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
59374000677	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374000678	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374000679	KilA-N domain; Region: KilA-N; pfam04383
59374000680	heat shock protein 90; Provisional; Region: PRK05218
59374000681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374000682	ATP binding site [chemical binding]; other site
59374000683	Mg2+ binding site [ion binding]; other site
59374000684	G-X-G motif; other site
59374000685	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000686	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000687	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000688	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
59374000689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
59374000690	DNA-binding site [nucleotide binding]; DNA binding site
59374000691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374000692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374000693	homodimer interface [polypeptide binding]; other site
59374000694	catalytic residue [active]
59374000695	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
59374000696	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
59374000697	active site
59374000698	multimer interface [polypeptide binding]; other site
59374000699	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
59374000700	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
59374000701	predicted active site [active]
59374000702	catalytic triad [active]
59374000703	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
59374000704	hypothetical protein; Provisional; Region: PRK13663
59374000705	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
59374000706	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
59374000707	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59374000708	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
59374000709	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
59374000710	active site
59374000711	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
59374000712	Part of AAA domain; Region: AAA_19; pfam13245
59374000713	Family description; Region: UvrD_C_2; pfam13538
59374000714	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
59374000715	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
59374000716	substrate binding site; other site
59374000717	dimer interface; other site
59374000718	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
59374000719	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
59374000720	putative tRNA-binding site [nucleotide binding]; other site
59374000721	B3/4 domain; Region: B3_4; pfam03483
59374000722	tRNA synthetase B5 domain; Region: B5; smart00874
59374000723	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
59374000724	dimer interface [polypeptide binding]; other site
59374000725	motif 1; other site
59374000726	motif 3; other site
59374000727	motif 2; other site
59374000728	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
59374000729	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
59374000730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374000731	Walker A motif; other site
59374000732	ATP binding site [chemical binding]; other site
59374000733	Walker B motif; other site
59374000734	arginine finger; other site
59374000735	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
59374000736	hypothetical protein; Validated; Region: PRK00153
59374000737	Outer membrane efflux protein; Region: OEP; pfam02321
59374000738	Outer membrane efflux protein; Region: OEP; pfam02321
59374000739	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
59374000740	HlyD family secretion protein; Region: HlyD_3; pfam13437
59374000741	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
59374000742	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
59374000743	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374000744	Walker A motif; other site
59374000745	ATP binding site [chemical binding]; other site
59374000746	Walker B motif; other site
59374000747	DNA primase, catalytic core; Region: dnaG; TIGR01391
59374000748	CHC2 zinc finger; Region: zf-CHC2; cl17510
59374000749	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
59374000750	active site
59374000751	metal binding site [ion binding]; metal-binding site
59374000752	interdomain interaction site; other site
59374000753	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
59374000754	FAD binding domain; Region: FAD_binding_4; pfam01565
59374000755	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
59374000756	Predicted integral membrane protein [Function unknown]; Region: COG5652
59374000757	FecR protein; Region: FecR; pfam04773
59374000758	PUA domain; Region: PUA; cl00607
59374000759	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
59374000760	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
59374000761	putative RNA binding site [nucleotide binding]; other site
59374000762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374000763	S-adenosylmethionine binding site [chemical binding]; other site
59374000764	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
59374000765	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
59374000766	N- and C-terminal domain interface [polypeptide binding]; other site
59374000767	active site
59374000768	MgATP binding site [chemical binding]; other site
59374000769	catalytic site [active]
59374000770	metal binding site [ion binding]; metal-binding site
59374000771	xylulose binding site [chemical binding]; other site
59374000772	putative homodimer interface [polypeptide binding]; other site
59374000773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374000774	binding surface
59374000775	TPR repeat; Region: TPR_11; pfam13414
59374000776	TPR motif; other site
59374000777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374000778	binding surface
59374000779	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59374000780	TPR motif; other site
59374000781	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
59374000782	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000783	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000784	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
59374000785	active site
59374000786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
59374000787	putative DNA binding site [nucleotide binding]; other site
59374000788	dimerization interface [polypeptide binding]; other site
59374000789	putative Zn2+ binding site [ion binding]; other site
59374000790	Methyltransferase domain; Region: Methyltransf_23; pfam13489
59374000791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374000792	S-adenosylmethionine binding site [chemical binding]; other site
59374000793	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
59374000794	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
59374000795	GIY-YIG motif/motif A; other site
59374000796	putative active site [active]
59374000797	putative metal binding site [ion binding]; other site
59374000798	Domain of unknown function (DUF4423); Region: DUF4423; pfam14394
59374000799	ketol-acid reductoisomerase; Validated; Region: PRK05225
59374000800	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
59374000801	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
59374000802	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
59374000803	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000804	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000805	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
59374000806	DNA-binding site [nucleotide binding]; DNA binding site
59374000807	RNA-binding motif; other site
59374000808	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
59374000809	active site
59374000810	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
59374000811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374000812	NAD(P) binding site [chemical binding]; other site
59374000813	active site
59374000814	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374000815	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374000816	non-specific DNA binding site [nucleotide binding]; other site
59374000817	salt bridge; other site
59374000818	sequence-specific DNA binding site [nucleotide binding]; other site
59374000819	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
59374000820	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
59374000821	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374000822	Coenzyme A binding pocket [chemical binding]; other site
59374000823	Predicted membrane protein [Function unknown]; Region: COG4270
59374000824	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
59374000825	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
59374000826	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374000827	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
59374000828	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
59374000829	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
59374000830	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
59374000831	dimer interface [polypeptide binding]; other site
59374000832	active site
59374000833	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59374000834	catalytic residues [active]
59374000835	substrate binding site [chemical binding]; other site
59374000836	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
59374000837	Fe-S metabolism associated domain; Region: SufE; cl00951
59374000838	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
59374000839	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59374000840	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
59374000841	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59374000842	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59374000843	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59374000844	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59374000845	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
59374000846	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59374000847	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
59374000848	DNA repair protein RadA; Provisional; Region: PRK11823
59374000849	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374000850	Walker A motif; other site
59374000851	ATP binding site [chemical binding]; other site
59374000852	Walker B motif; other site
59374000853	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
59374000854	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374000855	metal binding site [ion binding]; metal-binding site
59374000856	active site
59374000857	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
59374000858	Response regulator receiver domain; Region: Response_reg; pfam00072
59374000859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374000860	active site
59374000861	phosphorylation site [posttranslational modification]
59374000862	intermolecular recognition site; other site
59374000863	dimerization interface [polypeptide binding]; other site
59374000864	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
59374000865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374000866	NAD(P) binding site [chemical binding]; other site
59374000867	active site
59374000868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374000869	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374000870	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374000871	sequence-specific DNA binding site [nucleotide binding]; other site
59374000872	salt bridge; other site
59374000873	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
59374000874	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
59374000875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374000876	S-adenosylmethionine binding site [chemical binding]; other site
59374000877	hypothetical protein; Provisional; Region: PRK04233
59374000878	SEC-C motif; Region: SEC-C; pfam02810
59374000879	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
59374000880	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
59374000881	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000882	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000883	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
59374000884	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
59374000885	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374000886	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
59374000887	GTP1/OBG; Region: GTP1_OBG; pfam01018
59374000888	Obg GTPase; Region: Obg; cd01898
59374000889	G1 box; other site
59374000890	GTP/Mg2+ binding site [chemical binding]; other site
59374000891	Switch I region; other site
59374000892	G2 box; other site
59374000893	G3 box; other site
59374000894	Switch II region; other site
59374000895	G4 box; other site
59374000896	G5 box; other site
59374000897	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
59374000898	IHF dimer interface [polypeptide binding]; other site
59374000899	IHF - DNA interface [nucleotide binding]; other site
59374000900	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
59374000901	SmpB-tmRNA interface; other site
59374000902	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
59374000903	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
59374000904	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
59374000905	active site
59374000906	metal binding site [ion binding]; metal-binding site
59374000907	hypothetical protein; Validated; Region: PRK00110
59374000908	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
59374000909	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
59374000910	active site
59374000911	substrate binding site [chemical binding]; other site
59374000912	metal binding site [ion binding]; metal-binding site
59374000913	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374000914	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
59374000915	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
59374000916	dimer interface [polypeptide binding]; other site
59374000917	active site
59374000918	catalytic residue [active]
59374000919	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
59374000920	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
59374000921	DNA gyrase subunit A; Validated; Region: PRK05560
59374000922	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
59374000923	CAP-like domain; other site
59374000924	active site
59374000925	primary dimer interface [polypeptide binding]; other site
59374000926	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59374000927	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59374000928	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59374000929	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59374000930	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59374000931	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59374000932	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
59374000933	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59374000934	TIGR02147 family protein; Region: Fsuc_second
59374000935	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374000936	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
59374000937	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
59374000938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59374000939	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
59374000940	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
59374000941	anti sigma factor interaction site; other site
59374000942	regulatory phosphorylation site [posttranslational modification]; other site
59374000943	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
59374000944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
59374000945	ATP binding site [chemical binding]; other site
59374000946	Mg2+ binding site [ion binding]; other site
59374000947	G-X-G motif; other site
59374000948	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
59374000949	putative active site [active]
59374000950	nucleotide binding site [chemical binding]; other site
59374000951	nudix motif; other site
59374000952	putative metal binding site [ion binding]; other site
59374000953	Lipopolysaccharide-assembly; Region: LptE; pfam04390
59374000954	PA14 domain; Region: PA14; cl08459
59374000955	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
59374000956	Phosphoglycerate kinase; Region: PGK; pfam00162
59374000957	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
59374000958	substrate binding site [chemical binding]; other site
59374000959	hinge regions; other site
59374000960	ADP binding site [chemical binding]; other site
59374000961	catalytic site [active]
59374000962	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
59374000963	homooctamer interface [polypeptide binding]; other site
59374000964	active site
59374000965	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
59374000966	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
59374000967	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374000968	Walker A motif; other site
59374000969	ATP binding site [chemical binding]; other site
59374000970	Walker B motif; other site
59374000971	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
59374000972	SpoVG; Region: SpoVG; cl00915
59374000973	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
59374000974	putative ligand binding site [chemical binding]; other site
59374000975	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
59374000976	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
59374000977	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
59374000978	pseudouridine synthase; Region: TIGR00093
59374000979	active site
59374000980	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
59374000981	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374000982	putative metal binding site [ion binding]; other site
59374000983	fumarate hydratase; Provisional; Region: PRK15389
59374000984	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
59374000985	Fumarase C-terminus; Region: Fumerase_C; pfam05683
59374000986	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
59374000987	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374000988	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
59374000989	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374000990	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
59374000991	PAS domain; Region: PAS; smart00091
59374000992	PAS domain; Region: PAS_9; pfam13426
59374000993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374000994	ATP binding site [chemical binding]; other site
59374000995	Mg2+ binding site [ion binding]; other site
59374000996	G-X-G motif; other site
59374000997	Response regulator receiver domain; Region: Response_reg; pfam00072
59374000998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374000999	active site
59374001000	phosphorylation site [posttranslational modification]
59374001001	intermolecular recognition site; other site
59374001002	dimerization interface [polypeptide binding]; other site
59374001003	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
59374001004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
59374001005	active site
59374001006	phosphorylation site [posttranslational modification]
59374001007	intermolecular recognition site; other site
59374001008	dimerization interface [polypeptide binding]; other site
59374001009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374001010	Walker A motif; other site
59374001011	ATP binding site [chemical binding]; other site
59374001012	Walker B motif; other site
59374001013	arginine finger; other site
59374001014	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374001015	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
59374001016	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
59374001017	putative RNA binding site [nucleotide binding]; other site
59374001018	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59374001019	S-adenosylmethionine binding site [chemical binding]; other site
59374001020	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
59374001021	ATP cone domain; Region: ATP-cone; pfam03477
59374001022	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
59374001023	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
59374001024	TPP-binding site [chemical binding]; other site
59374001025	dimer interface [polypeptide binding]; other site
59374001026	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
59374001027	PYR/PP interface [polypeptide binding]; other site
59374001028	dimer interface [polypeptide binding]; other site
59374001029	TPP binding site [chemical binding]; other site
59374001030	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
59374001031	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
59374001032	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
59374001033	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
59374001034	Ligand binding site; other site
59374001035	Putative Catalytic site; other site
59374001036	DXD motif; other site
59374001037	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
59374001038	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
59374001039	catalytic site [active]
59374001040	G-X2-G-X-G-K; other site
59374001041	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
59374001042	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374001043	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374001044	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
59374001045	primosome assembly protein PriA; Validated; Region: PRK05580
59374001046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374001047	ATP binding site [chemical binding]; other site
59374001048	putative Mg++ binding site [ion binding]; other site
59374001049	helicase superfamily c-terminal domain; Region: HELICc; smart00490
59374001050	HEAT repeats; Region: HEAT_2; pfam13646
59374001051	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
59374001052	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
59374001053	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
59374001054	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
59374001055	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
59374001056	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
59374001057	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
59374001058	Cna protein B-type domain; Region: Cna_B_2; pfam13715
59374001059	Predicted amidohydrolase [General function prediction only]; Region: COG0388
59374001060	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
59374001061	active site
59374001062	catalytic triad [active]
59374001063	dimer interface [polypeptide binding]; other site
59374001064	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
59374001065	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
59374001066	serine acetyltransferase; Provisional; Region: cysE; PRK11132
59374001067	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
59374001068	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
59374001069	trimer interface [polypeptide binding]; other site
59374001070	active site
59374001071	substrate binding site [chemical binding]; other site
59374001072	CoA binding site [chemical binding]; other site
59374001073	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
59374001074	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
59374001075	minor groove reading motif; other site
59374001076	helix-hairpin-helix signature motif; other site
59374001077	substrate binding pocket [chemical binding]; other site
59374001078	active site
59374001079	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
59374001080	TPR repeat; Region: TPR_11; pfam13414
59374001081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374001082	binding surface
59374001083	TPR motif; other site
59374001084	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
59374001085	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374001086	active site
59374001087	HIGH motif; other site
59374001088	nucleotide binding site [chemical binding]; other site
59374001089	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
59374001090	KMSKS motif; other site
59374001091	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
59374001092	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
59374001093	EamA-like transporter family; Region: EamA; pfam00892
59374001094	EamA-like transporter family; Region: EamA; pfam00892
59374001095	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
59374001096	ThiC-associated domain; Region: ThiC-associated; pfam13667
59374001097	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
59374001098	ThiC family; Region: ThiC; pfam01964
59374001099	AAA domain; Region: AAA_25; pfam13481
59374001100	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374001101	Walker A motif; other site
59374001102	ATP binding site [chemical binding]; other site
59374001103	Walker B motif; other site
59374001104	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374001105	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
59374001106	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374001107	dimer interface [polypeptide binding]; other site
59374001108	phosphorylation site [posttranslational modification]
59374001109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374001110	ATP binding site [chemical binding]; other site
59374001111	Mg2+ binding site [ion binding]; other site
59374001112	G-X-G motif; other site
59374001113	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
59374001114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374001115	active site
59374001116	phosphorylation site [posttranslational modification]
59374001117	intermolecular recognition site; other site
59374001118	dimerization interface [polypeptide binding]; other site
59374001119	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59374001120	DNA binding site [nucleotide binding]
59374001121	PQQ-like domain; Region: PQQ_2; pfam13360
59374001122	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
59374001123	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
59374001124	substrate binding site [chemical binding]; other site
59374001125	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
59374001126	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
59374001127	murein peptide amidase A; Provisional; Region: PRK10602
59374001128	active site
59374001129	Zn binding site [ion binding]; other site
59374001130	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
59374001131	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
59374001132	active site
59374001133	putative DNA-binding cleft [nucleotide binding]; other site
59374001134	dimer interface [polypeptide binding]; other site
59374001135	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
59374001136	CHC2 zinc finger; Region: zf-CHC2; cl17510
59374001137	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
59374001138	active site
59374001139	metal binding site [ion binding]; metal-binding site
59374001140	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374001141	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59374001142	phosphoglycolate phosphatase; Provisional; Region: PRK13222
59374001143	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59374001144	motif II; other site
59374001145	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
59374001146	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
59374001147	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374001148	catalytic residue [active]
59374001149	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
59374001150	Ligand Binding Site [chemical binding]; other site
59374001151	Gram-negative bacterial tonB protein; Region: TonB; cl10048
59374001152	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
59374001153	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
59374001154	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
59374001155	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
59374001156	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374001157	FeS/SAM binding site; other site
59374001158	TRAM domain; Region: TRAM; pfam01938
59374001159	Sporulation related domain; Region: SPOR; pfam05036
59374001160	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
59374001161	tetramerization interface [polypeptide binding]; other site
59374001162	active site
59374001163	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
59374001164	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
59374001165	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
59374001166	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
59374001167	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
59374001168	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
59374001169	active site
59374001170	HIGH motif; other site
59374001171	KMSK motif region; other site
59374001172	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
59374001173	tRNA binding surface [nucleotide binding]; other site
59374001174	anticodon binding site; other site
59374001175	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001176	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
59374001177	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
59374001178	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
59374001179	putative active site [active]
59374001180	putative substrate binding site [chemical binding]; other site
59374001181	putative cosubstrate binding site; other site
59374001182	catalytic site [active]
59374001183	Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616
59374001184	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374001185	active site
59374001186	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374001187	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
59374001188	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
59374001189	ATP binding site [chemical binding]; other site
59374001190	Mg++ binding site [ion binding]; other site
59374001191	motif III; other site
59374001192	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374001193	nucleotide binding region [chemical binding]; other site
59374001194	ATP-binding site [chemical binding]; other site
59374001195	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
59374001196	active site
59374001197	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
59374001198	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
59374001199	elongation factor G; Reviewed; Region: PRK12740
59374001200	G1 box; other site
59374001201	putative GEF interaction site [polypeptide binding]; other site
59374001202	GTP/Mg2+ binding site [chemical binding]; other site
59374001203	Switch I region; other site
59374001204	G2 box; other site
59374001205	G3 box; other site
59374001206	Switch II region; other site
59374001207	G4 box; other site
59374001208	G5 box; other site
59374001209	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
59374001210	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
59374001211	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
59374001212	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
59374001213	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
59374001214	homodimer interface [polypeptide binding]; other site
59374001215	metal binding site [ion binding]; metal-binding site
59374001216	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
59374001217	homodimer interface [polypeptide binding]; other site
59374001218	active site
59374001219	putative chemical substrate binding site [chemical binding]; other site
59374001220	metal binding site [ion binding]; metal-binding site
59374001221	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
59374001222	DNA protecting protein DprA; Region: dprA; TIGR00732
59374001223	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
59374001224	Septum formation initiator; Region: DivIC; pfam04977
59374001225	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
59374001226	Protein export membrane protein; Region: SecD_SecF; cl14618
59374001227	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
59374001228	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
59374001229	HlyD family secretion protein; Region: HlyD_3; pfam13437
59374001230	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
59374001231	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
59374001232	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
59374001233	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
59374001234	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
59374001235	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
59374001236	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374001237	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
59374001238	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
59374001239	active site
59374001240	HIGH motif; other site
59374001241	dimer interface [polypeptide binding]; other site
59374001242	KMSKS motif; other site
59374001243	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
59374001244	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
59374001245	catalytic site [active]
59374001246	putative active site [active]
59374001247	putative substrate binding site [chemical binding]; other site
59374001248	HRDC domain; Region: HRDC; pfam00570
59374001249	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
59374001250	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
59374001251	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
59374001252	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59374001253	CotH protein; Region: CotH; pfam08757
59374001254	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59374001255	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59374001256	dimer interface [polypeptide binding]; other site
59374001257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374001258	catalytic residue [active]
59374001259	TIGR02147 family protein; Region: Fsuc_second
59374001260	Rubrerythrin [Energy production and conversion]; Region: COG1592
59374001261	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
59374001262	binuclear metal center [ion binding]; other site
59374001263	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
59374001264	iron binding site [ion binding]; other site
59374001265	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
59374001266	arginine decarboxylase; Provisional; Region: PRK05354
59374001267	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
59374001268	dimer interface [polypeptide binding]; other site
59374001269	active site
59374001270	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59374001271	catalytic residues [active]
59374001272	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
59374001273	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374001274	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
59374001275	Probable Catalytic site; other site
59374001276	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374001277	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
59374001278	Probable Catalytic site; other site
59374001279	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374001280	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374001281	active site
59374001282	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
59374001283	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
59374001284	putative NADH binding site [chemical binding]; other site
59374001285	putative active site [active]
59374001286	nudix motif; other site
59374001287	putative metal binding site [ion binding]; other site
59374001288	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
59374001289	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
59374001290	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
59374001291	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
59374001292	aspartoacylase; Provisional; Region: PRK02259
59374001293	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
59374001294	Sulfatase; Region: Sulfatase; pfam00884
59374001295	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
59374001296	Sulfatase; Region: Sulfatase; cl17466
59374001297	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
59374001298	Sulfatase; Region: Sulfatase; cl17466
59374001299	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
59374001300	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
59374001301	CAP-like domain; other site
59374001302	active site
59374001303	primary dimer interface [polypeptide binding]; other site
59374001304	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
59374001305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374001306	Walker A/P-loop; other site
59374001307	ATP binding site [chemical binding]; other site
59374001308	Q-loop/lid; other site
59374001309	ABC transporter signature motif; other site
59374001310	Walker B; other site
59374001311	D-loop; other site
59374001312	H-loop/switch region; other site
59374001313	SurA N-terminal domain; Region: SurA_N; pfam09312
59374001314	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
59374001315	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
59374001316	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
59374001317	DEAD-like helicases superfamily; Region: DEXDc; smart00487
59374001318	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374001319	ATP binding site [chemical binding]; other site
59374001320	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
59374001321	putative Mg++ binding site [ion binding]; other site
59374001322	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374001323	nucleotide binding region [chemical binding]; other site
59374001324	ATP-binding site [chemical binding]; other site
59374001325	Helicase associated domain (HA2); Region: HA2; pfam04408
59374001326	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
59374001327	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
59374001328	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
59374001329	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
59374001330	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
59374001331	DNA primase; Validated; Region: dnaG; PRK05667
59374001332	CHC2 zinc finger; Region: zf-CHC2; pfam01807
59374001333	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
59374001334	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
59374001335	active site
59374001336	metal binding site [ion binding]; metal-binding site
59374001337	interdomain interaction site; other site
59374001338	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
59374001339	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
59374001340	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
59374001341	Walker A/P-loop; other site
59374001342	ATP binding site [chemical binding]; other site
59374001343	Q-loop/lid; other site
59374001344	ABC transporter signature motif; other site
59374001345	Walker B; other site
59374001346	D-loop; other site
59374001347	H-loop/switch region; other site
59374001348	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
59374001349	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
59374001350	putative transporter; Provisional; Region: PRK11660
59374001351	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
59374001352	Sulfate transporter family; Region: Sulfate_transp; pfam00916
59374001353	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
59374001354	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
59374001355	CPxP  motif; other site
59374001356	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
59374001357	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
59374001358	DXD motif; other site
59374001359	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
59374001360	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
59374001361	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374001362	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374001363	Protein of unknown function (DUF342); Region: DUF342; pfam03961
59374001364	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
59374001365	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
59374001366	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
59374001367	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
59374001368	TIGR02147 family protein; Region: Fsuc_second
59374001369	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
59374001370	aspartate racemase; Region: asp_race; TIGR00035
59374001371	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
59374001372	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
59374001373	ATP binding site [chemical binding]; other site
59374001374	Mg2+ binding site [ion binding]; other site
59374001375	G-X-G motif; other site
59374001376	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
59374001377	ATP binding site [chemical binding]; other site
59374001378	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
59374001379	active site
59374001380	putative metal-binding site [ion binding]; other site
59374001381	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
59374001382	FOG: CBS domain [General function prediction only]; Region: COG0517
59374001383	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
59374001384	Transporter associated domain; Region: CorC_HlyC; smart01091
59374001385	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
59374001386	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
59374001387	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
59374001388	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
59374001389	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
59374001390	putative metal binding residues [ion binding]; other site
59374001391	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
59374001392	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59374001393	active site
59374001394	motif I; other site
59374001395	motif II; other site
59374001396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59374001397	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
59374001398	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
59374001399	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
59374001400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374001401	ATP-grasp domain; Region: ATP-grasp; pfam02222
59374001402	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
59374001403	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001404	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001405	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001406	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001407	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001408	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001409	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001410	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001411	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001412	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
59374001413	cell division protein FtsZ; Validated; Region: PRK09330
59374001414	nucleotide binding site [chemical binding]; other site
59374001415	SulA interaction site; other site
59374001416	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
59374001417	Cell division protein FtsA; Region: FtsA; smart00842
59374001418	Cell division protein FtsA; Region: FtsA; pfam14450
59374001419	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
59374001420	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
59374001421	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
59374001422	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59374001423	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59374001424	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
59374001425	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
59374001426	active site
59374001427	homodimer interface [polypeptide binding]; other site
59374001428	cell division protein FtsW; Region: ftsW; TIGR02614
59374001429	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
59374001430	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
59374001431	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59374001432	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59374001433	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
59374001434	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59374001435	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59374001436	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
59374001437	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
59374001438	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
59374001439	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
59374001440	MraW methylase family; Region: Methyltransf_5; cl17771
59374001441	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
59374001442	cell division protein MraZ; Reviewed; Region: PRK00326
59374001443	MraZ protein; Region: MraZ; pfam02381
59374001444	MraZ protein; Region: MraZ; pfam02381
59374001445	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
59374001446	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59374001447	catalytic residues [active]
59374001448	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
59374001449	FAD binding site [chemical binding]; other site
59374001450	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
59374001451	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374001452	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374001453	ligand binding site [chemical binding]; other site
59374001454	HD domain; Region: HD_4; pfam13328
59374001455	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
59374001456	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374001457	catalytic residue [active]
59374001458	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
59374001459	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
59374001460	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
59374001461	putative active site [active]
59374001462	dimerization interface [polypeptide binding]; other site
59374001463	putative tRNAtyr binding site [nucleotide binding]; other site
59374001464	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
59374001465	active site
59374001466	homodimer interface [polypeptide binding]; other site
59374001467	homotetramer interface [polypeptide binding]; other site
59374001468	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
59374001469	Domain of unknown function (DUF4423); Region: DUF4423; pfam14394
59374001470	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
59374001471	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
59374001472	GTP-binding protein YchF; Reviewed; Region: PRK09601
59374001473	YchF GTPase; Region: YchF; cd01900
59374001474	G1 box; other site
59374001475	GTP/Mg2+ binding site [chemical binding]; other site
59374001476	Switch I region; other site
59374001477	G2 box; other site
59374001478	Switch II region; other site
59374001479	G3 box; other site
59374001480	G4 box; other site
59374001481	G5 box; other site
59374001482	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
59374001483	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374001484	Uncharacterized conserved protein [Function unknown]; Region: COG1262
59374001485	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
59374001486	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
59374001487	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
59374001488	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
59374001489	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
59374001490	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
59374001491	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
59374001492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374001493	Walker A/P-loop; other site
59374001494	ATP binding site [chemical binding]; other site
59374001495	Q-loop/lid; other site
59374001496	ABC transporter signature motif; other site
59374001497	Walker B; other site
59374001498	D-loop; other site
59374001499	H-loop/switch region; other site
59374001500	TIGR02147 family protein; Region: Fsuc_second
59374001501	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
59374001502	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
59374001503	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
59374001504	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
59374001505	Family description; Region: UvrD_C_2; pfam13538
59374001506	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
59374001507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
59374001508	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
59374001509	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
59374001510	Chloramphenicol acetyltransferase; Region: CAT; cl02008
59374001511	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
59374001512	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59374001513	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374001514	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
59374001515	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
59374001516	GAF domain; Region: GAF_3; pfam13492
59374001517	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
59374001518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374001519	Walker A motif; other site
59374001520	ATP binding site [chemical binding]; other site
59374001521	Walker B motif; other site
59374001522	arginine finger; other site
59374001523	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374001524	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
59374001525	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
59374001526	active site
59374001527	ATP binding site [chemical binding]; other site
59374001528	substrate binding site [chemical binding]; other site
59374001529	activation loop (A-loop); other site
59374001530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374001531	binding surface
59374001532	TPR motif; other site
59374001533	TPR repeat; Region: TPR_11; pfam13414
59374001534	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
59374001535	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
59374001536	nudix motif; other site
59374001537	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
59374001538	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
59374001539	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
59374001540	dimerization interface [polypeptide binding]; other site
59374001541	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374001542	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374001543	metal binding site [ion binding]; metal-binding site
59374001544	active site
59374001545	I-site; other site
59374001546	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
59374001547	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
59374001548	FMN binding site [chemical binding]; other site
59374001549	active site
59374001550	catalytic residues [active]
59374001551	substrate binding site [chemical binding]; other site
59374001552	ornithine carbamoyltransferase; Provisional; Region: PRK00779
59374001553	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
59374001554	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
59374001555	biotin synthase; Region: bioB; TIGR00433
59374001556	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374001557	FeS/SAM binding site; other site
59374001558	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
59374001559	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
59374001560	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434
59374001561	active site
59374001562	zinc binding site [ion binding]; other site
59374001563	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59374001564	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59374001565	dimer interface [polypeptide binding]; other site
59374001566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374001567	catalytic residue [active]
59374001568	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
59374001569	classical (c) SDRs; Region: SDR_c; cd05233
59374001570	NAD(P) binding site [chemical binding]; other site
59374001571	active site
59374001572	NlpC/P60 family; Region: NLPC_P60; pfam00877
59374001573	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
59374001574	Prephenate dehydratase; Region: PDT; pfam00800
59374001575	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
59374001576	putative L-Phe binding site [chemical binding]; other site
59374001577	ribonuclease PH; Reviewed; Region: rph; PRK00173
59374001578	Ribonuclease PH; Region: RNase_PH_bact; cd11362
59374001579	hexamer interface [polypeptide binding]; other site
59374001580	active site
59374001581	TIGR02147 family protein; Region: Fsuc_second
59374001582	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
59374001583	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
59374001584	putative active site [active]
59374001585	oxyanion strand; other site
59374001586	catalytic triad [active]
59374001587	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
59374001588	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
59374001589	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001590	argininosuccinate synthase; Provisional; Region: PRK13820
59374001591	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
59374001592	ANP binding site [chemical binding]; other site
59374001593	Substrate Binding Site II [chemical binding]; other site
59374001594	Substrate Binding Site I [chemical binding]; other site
59374001595	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
59374001596	mce related protein; Region: MCE; pfam02470
59374001597	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
59374001598	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
59374001599	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
59374001600	generic binding surface II; other site
59374001601	ssDNA binding site; other site
59374001602	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374001603	ATP binding site [chemical binding]; other site
59374001604	putative Mg++ binding site [ion binding]; other site
59374001605	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374001606	nucleotide binding region [chemical binding]; other site
59374001607	ATP-binding site [chemical binding]; other site
59374001608	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
59374001609	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
59374001610	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
59374001611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374001612	Walker A/P-loop; other site
59374001613	ATP binding site [chemical binding]; other site
59374001614	Q-loop/lid; other site
59374001615	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374001616	ABC transporter; Region: ABC_tran_2; pfam12848
59374001617	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374001618	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374001619	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
59374001620	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
59374001621	trimer interface [polypeptide binding]; other site
59374001622	active site
59374001623	substrate binding site [chemical binding]; other site
59374001624	CoA binding site [chemical binding]; other site
59374001625	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
59374001626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374001627	ATP binding site [chemical binding]; other site
59374001628	putative Mg++ binding site [ion binding]; other site
59374001629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374001630	nucleotide binding region [chemical binding]; other site
59374001631	ATP-binding site [chemical binding]; other site
59374001632	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
59374001633	HRDC domain; Region: HRDC; pfam00570
59374001634	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
59374001635	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
59374001636	homodimer interface [polypeptide binding]; other site
59374001637	substrate-cofactor binding pocket; other site
59374001638	catalytic residue [active]
59374001639	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
59374001640	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
59374001641	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
59374001642	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374001643	FIST N domain; Region: FIST; pfam08495
59374001644	FIST C domain; Region: FIST_C; pfam10442
59374001645	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374001646	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374001647	metal binding site [ion binding]; metal-binding site
59374001648	active site
59374001649	I-site; other site
59374001650	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374001651	Zn2+ binding site [ion binding]; other site
59374001652	Mg2+ binding site [ion binding]; other site
59374001653	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
59374001654	dimer interface [polypeptide binding]; other site
59374001655	Citrate synthase; Region: Citrate_synt; pfam00285
59374001656	active site
59374001657	citrylCoA binding site [chemical binding]; other site
59374001658	NADH binding [chemical binding]; other site
59374001659	cationic pore residues; other site
59374001660	oxalacetate/citrate binding site [chemical binding]; other site
59374001661	coenzyme A binding site [chemical binding]; other site
59374001662	catalytic triad [active]
59374001663	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
59374001664	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374001665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374001666	homodimer interface [polypeptide binding]; other site
59374001667	catalytic residue [active]
59374001668	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
59374001669	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
59374001670	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374001671	Zn2+ binding site [ion binding]; other site
59374001672	Mg2+ binding site [ion binding]; other site
59374001673	TIGR02147 family protein; Region: Fsuc_second
59374001674	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
59374001675	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
59374001676	FMN binding site [chemical binding]; other site
59374001677	active site
59374001678	catalytic residues [active]
59374001679	substrate binding site [chemical binding]; other site
59374001680	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
59374001681	IHF dimer interface [polypeptide binding]; other site
59374001682	IHF - DNA interface [nucleotide binding]; other site
59374001683	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
59374001684	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
59374001685	RNA binding surface [nucleotide binding]; other site
59374001686	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
59374001687	active site
59374001688	uracil binding [chemical binding]; other site
59374001689	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
59374001690	Outer membrane efflux protein; Region: OEP; pfam02321
59374001691	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
59374001692	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
59374001693	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
59374001694	N-acetyl-D-glucosamine binding site [chemical binding]; other site
59374001695	catalytic residue [active]
59374001696	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
59374001697	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
59374001698	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
59374001699	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
59374001700	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
59374001701	active site
59374001702	hydrophilic channel; other site
59374001703	dimerization interface [polypeptide binding]; other site
59374001704	catalytic residues [active]
59374001705	active site lid [active]
59374001706	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
59374001707	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
59374001708	dimerization interface 3.5A [polypeptide binding]; other site
59374001709	active site
59374001710	AAA ATPase domain; Region: AAA_15; pfam13175
59374001711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374001712	Walker A/P-loop; other site
59374001713	ATP binding site [chemical binding]; other site
59374001714	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374001715	Walker B; other site
59374001716	D-loop; other site
59374001717	H-loop/switch region; other site
59374001718	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
59374001719	active site
59374001720	metal binding site [ion binding]; metal-binding site
59374001721	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
59374001722	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
59374001723	TIGR02147 family protein; Region: Fsuc_second
59374001724	Pectic acid lyase; Region: Pec_lyase; pfam09492
59374001725	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374001726	Ca binding site [ion binding]; other site
59374001727	Ca binding site (active) [ion binding]; other site
59374001728	ligand binding site [chemical binding]; other site
59374001729	putative pectinesterase; Region: PLN02432; cl01911
59374001730	Pectinesterase; Region: Pectinesterase; pfam01095
59374001731	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374001732	Ca binding site [ion binding]; other site
59374001733	Ca binding site (active) [ion binding]; other site
59374001734	ligand binding site [chemical binding]; other site
59374001735	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001736	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001737	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
59374001738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374001739	ATP binding site [chemical binding]; other site
59374001740	Mg2+ binding site [ion binding]; other site
59374001741	G-X-G motif; other site
59374001742	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
59374001743	ATP binding site [chemical binding]; other site
59374001744	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
59374001745	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
59374001746	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
59374001747	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
59374001748	PHP domain; Region: PHP; pfam02811
59374001749	active site
59374001750	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
59374001751	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
59374001752	generic binding surface I; other site
59374001753	generic binding surface II; other site
59374001754	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374001755	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
59374001756	Probable Catalytic site; other site
59374001757	metal-binding site
59374001758	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
59374001759	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374001760	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374001761	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374001762	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
59374001763	glutamate racemase; Provisional; Region: PRK00865
59374001764	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
59374001765	Part of AAA domain; Region: AAA_19; pfam13245
59374001766	Family description; Region: UvrD_C_2; pfam13538
59374001767	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
59374001768	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
59374001769	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59374001770	putative acyl-acceptor binding pocket; other site
59374001771	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
59374001772	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374001773	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
59374001774	Methyltransferase domain; Region: Methyltransf_31; pfam13847
59374001775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374001776	S-adenosylmethionine binding site [chemical binding]; other site
59374001777	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
59374001778	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59374001779	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59374001780	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59374001781	DNA binding residues [nucleotide binding]
59374001782	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
59374001783	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
59374001784	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
59374001785	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374001786	active site
59374001787	HIGH motif; other site
59374001788	nucleotide binding site [chemical binding]; other site
59374001789	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
59374001790	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
59374001791	active site
59374001792	KMSKS motif; other site
59374001793	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
59374001794	tRNA binding surface [nucleotide binding]; other site
59374001795	anticodon binding site; other site
59374001796	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
59374001797	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374001798	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374001799	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374001800	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374001801	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374001802	amidophosphoribosyltransferase; Provisional; Region: PRK05793
59374001803	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
59374001804	active site
59374001805	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374001806	active site
59374001807	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
59374001808	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374001809	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59374001810	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374001811	active site
59374001812	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
59374001813	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374001814	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
59374001815	Probable Catalytic site; other site
59374001816	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
59374001817	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
59374001818	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
59374001819	Uncharacterized conserved protein [Function unknown]; Region: COG1543
59374001820	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
59374001821	active site
59374001822	substrate binding site [chemical binding]; other site
59374001823	catalytic site [active]
59374001824	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
59374001825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
59374001826	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
59374001827	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
59374001828	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
59374001829	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
59374001830	homodimer interface [polypeptide binding]; other site
59374001831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374001832	catalytic residue [active]
59374001833	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
59374001834	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
59374001835	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
59374001836	M6 family metalloprotease domain; Region: M6dom_TIGR03296
59374001837	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
59374001838	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
59374001839	trmE is a tRNA modification GTPase; Region: trmE; cd04164
59374001840	G1 box; other site
59374001841	GTP/Mg2+ binding site [chemical binding]; other site
59374001842	Switch I region; other site
59374001843	G2 box; other site
59374001844	Switch II region; other site
59374001845	G3 box; other site
59374001846	G4 box; other site
59374001847	G5 box; other site
59374001848	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
59374001849	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
59374001850	active site
59374001851	catalytic residues [active]
59374001852	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
59374001853	Ca binding site [ion binding]; other site
59374001854	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
59374001855	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001856	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
59374001857	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001858	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
59374001859	putative metal binding site [ion binding]; other site
59374001860	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
59374001861	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001862	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
59374001863	putative metal binding site [ion binding]; other site
59374001864	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
59374001865	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001866	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
59374001867	active site
59374001868	catalytic site [active]
59374001869	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
59374001870	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374001871	active site
59374001872	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
59374001873	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
59374001874	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
59374001875	Predicted transcriptional regulator [Transcription]; Region: COG2378
59374001876	WYL domain; Region: WYL; pfam13280
59374001877	BON domain; Region: BON; pfam04972
59374001878	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
59374001879	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
59374001880	HIGH motif; other site
59374001881	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
59374001882	active site
59374001883	KMSKS motif; other site
59374001884	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
59374001885	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
59374001886	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
59374001887	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
59374001888	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
59374001889	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
59374001890	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
59374001891	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
59374001892	Walker A/P-loop; other site
59374001893	ATP binding site [chemical binding]; other site
59374001894	Q-loop/lid; other site
59374001895	ABC transporter signature motif; other site
59374001896	Walker B; other site
59374001897	D-loop; other site
59374001898	H-loop/switch region; other site
59374001899	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
59374001900	Permease; Region: Permease; pfam02405
59374001901	replicative DNA helicase; Region: DnaB; TIGR00665
59374001902	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
59374001903	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
59374001904	Walker A motif; other site
59374001905	ATP binding site [chemical binding]; other site
59374001906	Walker B motif; other site
59374001907	DNA binding loops [nucleotide binding]
59374001908	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
59374001909	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
59374001910	Flavoprotein; Region: Flavoprotein; pfam02441
59374001911	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
59374001912	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
59374001913	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374001914	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
59374001915	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
59374001916	RNA binding site [nucleotide binding]; other site
59374001917	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
59374001918	RNA binding site [nucleotide binding]; other site
59374001919	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
59374001920	RNA binding site [nucleotide binding]; other site
59374001921	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
59374001922	RNA binding site [nucleotide binding]; other site
59374001923	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
59374001924	RNA binding site [nucleotide binding]; other site
59374001925	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
59374001926	RNA binding site [nucleotide binding]; other site
59374001927	cytidylate kinase; Provisional; Region: cmk; PRK00023
59374001928	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
59374001929	CMP-binding site; other site
59374001930	The sites determining sugar specificity; other site
59374001931	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
59374001932	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
59374001933	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001934	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374001935	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374001936	Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; Region: CY; cl09238
59374001937	putative proteinase inhibition site; other site
59374001938	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
59374001939	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374001940	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
59374001941	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59374001942	catalytic residues [active]
59374001943	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59374001944	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
59374001945	putative switch regulator; other site
59374001946	non-specific DNA interactions [nucleotide binding]; other site
59374001947	DNA binding site [nucleotide binding]
59374001948	sequence specific DNA binding site [nucleotide binding]; other site
59374001949	putative cAMP binding site [chemical binding]; other site
59374001950	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
59374001951	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
59374001952	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
59374001953	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374001954	active site
59374001955	HIGH motif; other site
59374001956	nucleotide binding site [chemical binding]; other site
59374001957	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374001958	active site
59374001959	KMSKS motif; other site
59374001960	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
59374001961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59374001962	putative substrate translocation pore; other site
59374001963	Major Facilitator Superfamily; Region: MFS_1; pfam07690
59374001964	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
59374001965	Predicted membrane protein [Function unknown]; Region: COG4763
59374001966	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374001967	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
59374001968	excinuclease ABC subunit B; Provisional; Region: PRK05298
59374001969	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374001970	ATP binding site [chemical binding]; other site
59374001971	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374001972	nucleotide binding region [chemical binding]; other site
59374001973	ATP-binding site [chemical binding]; other site
59374001974	Ultra-violet resistance protein B; Region: UvrB; pfam12344
59374001975	UvrB/uvrC motif; Region: UVR; pfam02151
59374001976	phosphoglyceromutase; Provisional; Region: PRK05434
59374001977	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
59374001978	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
59374001979	PilX N-terminal; Region: PilX_N; pfam14341
59374001980	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374001981	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
59374001982	PilX N-terminal; Region: PilX_N; pfam14341
59374001983	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
59374001984	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
59374001985	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
59374001986	dimer interface [polypeptide binding]; other site
59374001987	motif 1; other site
59374001988	active site
59374001989	motif 2; other site
59374001990	motif 3; other site
59374001991	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
59374001992	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
59374001993	Substrate binding site; other site
59374001994	Cupin domain; Region: Cupin_2; cl17218
59374001995	polysaccharide export protein Wza; Provisional; Region: PRK15078
59374001996	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
59374001997	SLBB domain; Region: SLBB; pfam10531
59374001998	SLBB domain; Region: SLBB; pfam10531
59374001999	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
59374002000	Low molecular weight phosphatase family; Region: LMWPc; cd00115
59374002001	active site
59374002002	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
59374002003	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
59374002004	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
59374002005	NAD binding site [chemical binding]; other site
59374002006	substrate binding site [chemical binding]; other site
59374002007	homodimer interface [polypeptide binding]; other site
59374002008	active site
59374002009	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
59374002010	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
59374002011	substrate binding site; other site
59374002012	tetramer interface; other site
59374002013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374002014	ATP binding site [chemical binding]; other site
59374002015	putative Mg++ binding site [ion binding]; other site
59374002016	helicase superfamily c-terminal domain; Region: HELICc; smart00490
59374002017	nucleotide binding region [chemical binding]; other site
59374002018	ATP-binding site [chemical binding]; other site
59374002019	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
59374002020	Predicted permease; Region: DUF318; cl17795
59374002021	Predicted permease; Region: DUF318; cl17795
59374002022	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
59374002023	metal-binding site [ion binding]
59374002024	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
59374002025	dimerization interface [polypeptide binding]; other site
59374002026	putative DNA binding site [nucleotide binding]; other site
59374002027	putative Zn2+ binding site [ion binding]; other site
59374002028	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374002029	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
59374002030	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
59374002031	putative substrate binding site [chemical binding]; other site
59374002032	putative ATP binding site [chemical binding]; other site
59374002033	DNA polymerase I; Provisional; Region: PRK05755
59374002034	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
59374002035	active site
59374002036	metal binding site 1 [ion binding]; metal-binding site
59374002037	putative 5' ssDNA interaction site; other site
59374002038	metal binding site 3; metal-binding site
59374002039	metal binding site 2 [ion binding]; metal-binding site
59374002040	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
59374002041	putative DNA binding site [nucleotide binding]; other site
59374002042	putative metal binding site [ion binding]; other site
59374002043	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
59374002044	active site
59374002045	catalytic site [active]
59374002046	substrate binding site [chemical binding]; other site
59374002047	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
59374002048	active site
59374002049	DNA binding site [nucleotide binding]
59374002050	catalytic site [active]
59374002051	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374002052	TIGR02147 family protein; Region: Fsuc_second
59374002053	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
59374002054	Malic enzyme, N-terminal domain; Region: malic; pfam00390
59374002055	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
59374002056	putative NAD(P) binding site [chemical binding]; other site
59374002057	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
59374002058	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
59374002059	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
59374002060	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
59374002061	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
59374002062	23S rRNA binding site [nucleotide binding]; other site
59374002063	L21 binding site [polypeptide binding]; other site
59374002064	L13 binding site [polypeptide binding]; other site
59374002065	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
59374002066	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
59374002067	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
59374002068	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
59374002069	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
59374002070	Protein of unknown function (DUF497); Region: DUF497; pfam04365
59374002071	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
59374002072	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
59374002073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374002074	S-adenosylmethionine binding site [chemical binding]; other site
59374002075	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374002076	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374002077	Major Facilitator Superfamily; Region: MFS_1; pfam07690
59374002078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59374002079	putative substrate translocation pore; other site
59374002080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374002081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374002082	metal binding site [ion binding]; metal-binding site
59374002083	active site
59374002084	I-site; other site
59374002085	TIGR02147 family protein; Region: Fsuc_second
59374002086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374002087	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374002088	Walker A motif; other site
59374002089	ATP binding site [chemical binding]; other site
59374002090	Walker B motif; other site
59374002091	arginine finger; other site
59374002092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374002093	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374002094	Walker A motif; other site
59374002095	ATP binding site [chemical binding]; other site
59374002096	Walker B motif; other site
59374002097	arginine finger; other site
59374002098	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002099	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002100	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002101	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002102	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002103	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002104	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374002105	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
59374002106	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374002107	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
59374002108	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
59374002109	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59374002110	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
59374002111	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374002112	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
59374002113	IMP binding site; other site
59374002114	dimer interface [polypeptide binding]; other site
59374002115	interdomain contacts; other site
59374002116	partial ornithine binding site; other site
59374002117	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
59374002118	DNA protecting protein DprA; Region: dprA; TIGR00732
59374002119	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
59374002120	Family description; Region: VCBS; pfam13517
59374002121	Family description; Region: VCBS; pfam13517
59374002122	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
59374002123	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
59374002124	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
59374002125	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
59374002126	trimethylamine-N-oxide reductase TorA; Region: torA; TIGR02164
59374002127	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
59374002128	Family description; Region: VCBS; pfam13517
59374002129	Family description; Region: VCBS; pfam13517
59374002130	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
59374002131	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
59374002132	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
59374002133	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
59374002134	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
59374002135	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59374002136	Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538
59374002137	hypothetical protein; Provisional; Region: PRK07208
59374002138	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59374002139	Predicted membrane protein [Function unknown]; Region: COG2246
59374002140	GtrA-like protein; Region: GtrA; pfam04138
59374002141	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
59374002142	active site
59374002143	catalytic residues [active]
59374002144	TIGR02147 family protein; Region: Fsuc_second
59374002145	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
59374002146	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59374002147	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374002148	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
59374002149	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59374002150	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374002151	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
59374002152	IMP binding site; other site
59374002153	dimer interface [polypeptide binding]; other site
59374002154	interdomain contacts; other site
59374002155	partial ornithine binding site; other site
59374002156	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
59374002157	IHF - DNA interface [nucleotide binding]; other site
59374002158	IHF dimer interface [polypeptide binding]; other site
59374002159	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
59374002160	Domain of unknown function DUF20; Region: UPF0118; pfam01594
59374002161	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
59374002162	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59374002163	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002164	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002165	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374002166	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374002167	ligand binding site [chemical binding]; other site
59374002168	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
59374002169	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
59374002170	active site
59374002171	catalytic residues [active]
59374002172	metal binding site [ion binding]; metal-binding site
59374002173	homodimer binding site [polypeptide binding]; other site
59374002174	tetrathionate reductase subunit A; Provisional; Region: PRK14991
59374002175	Histidine kinase; Region: His_kinase; pfam06580
59374002176	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59374002177	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59374002178	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59374002179	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
59374002180	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59374002181	DNA binding residues [nucleotide binding]
59374002182	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
59374002183	C-terminal peptidase (prc); Region: prc; TIGR00225
59374002184	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
59374002185	protein binding site [polypeptide binding]; other site
59374002186	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
59374002187	Catalytic dyad [active]
59374002188	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
59374002189	Permease; Region: Permease; pfam02405
59374002190	Protein of unknown function (DUF721); Region: DUF721; pfam05258
59374002191	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
59374002192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374002193	ATP binding site [chemical binding]; other site
59374002194	Mg2+ binding site [ion binding]; other site
59374002195	G-X-G motif; other site
59374002196	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
59374002197	anchoring element; other site
59374002198	dimer interface [polypeptide binding]; other site
59374002199	ATP binding site [chemical binding]; other site
59374002200	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
59374002201	active site
59374002202	putative metal-binding site [ion binding]; other site
59374002203	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
59374002204	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
59374002205	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
59374002206	substrate binding pocket [chemical binding]; other site
59374002207	chain length determination region; other site
59374002208	substrate-Mg2+ binding site; other site
59374002209	catalytic residues [active]
59374002210	aspartate-rich region 1; other site
59374002211	active site lid residues [active]
59374002212	aspartate-rich region 2; other site
59374002213	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
59374002214	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
59374002215	oligomer interface [polypeptide binding]; other site
59374002216	Cl binding site [ion binding]; other site
59374002217	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
59374002218	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
59374002219	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
59374002220	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
59374002221	Protein export membrane protein; Region: SecD_SecF; pfam02355
59374002222	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
59374002223	active site
59374002224	homodimer interface [polypeptide binding]; other site
59374002225	catalytic site [active]
59374002226	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
59374002227	Oxygen tolerance; Region: BatD; pfam13584
59374002228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374002229	TPR motif; other site
59374002230	binding surface
59374002231	TPR repeat; Region: TPR_11; pfam13414
59374002232	Herpesvirus glycoprotein M; Region: Herpes_glycop; cl17339
59374002233	Bacterial SH3 domain homologues; Region: SH3b; smart00287
59374002234	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
59374002235	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
59374002236	Ligand Binding Site [chemical binding]; other site
59374002237	cell surface protein SprA; Region: surface_SprA; TIGR04189
59374002238	Motility related/secretion protein; Region: SprA_N; pfam14349
59374002239	Motility related/secretion protein; Region: SprA_N; pfam14349
59374002240	AIPR protein; Region: AIPR; pfam10592
59374002241	Leucine rich repeat; Region: LRR_8; pfam13855
59374002242	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
59374002243	Leucine rich repeat; Region: LRR_8; pfam13855
59374002244	C-terminal peptidase (prc); Region: prc; TIGR00225
59374002245	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
59374002246	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
59374002247	Active site serine [active]
59374002248	PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992
59374002249	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
59374002250	Active site serine [active]
59374002251	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374002252	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374002253	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
59374002254	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
59374002255	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374002256	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
59374002257	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
59374002258	glutaminase active site [active]
59374002259	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
59374002260	dimer interface [polypeptide binding]; other site
59374002261	active site
59374002262	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
59374002263	dimer interface [polypeptide binding]; other site
59374002264	active site
59374002265	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
59374002266	active site
59374002267	substrate binding site [chemical binding]; other site
59374002268	catalytic site [active]
59374002269	DEAD-like helicases superfamily; Region: DEXDc; smart00487
59374002270	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374002271	ATP binding site [chemical binding]; other site
59374002272	putative Mg++ binding site [ion binding]; other site
59374002273	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374002274	nucleotide binding region [chemical binding]; other site
59374002275	ATP-binding site [chemical binding]; other site
59374002276	Part of AAA domain; Region: AAA_19; pfam13245
59374002277	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
59374002278	Family description; Region: UvrD_C_2; pfam13538
59374002279	ORF6N domain; Region: ORF6N; pfam10543
59374002280	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
59374002281	putative active site [active]
59374002282	catalytic site [active]
59374002283	ScpA/B protein; Region: ScpA_ScpB; cl00598
59374002284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374002285	Coenzyme A binding pocket [chemical binding]; other site
59374002286	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
59374002287	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
59374002288	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
59374002289	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
59374002290	active site
59374002291	substrate binding site [chemical binding]; other site
59374002292	ATP binding site [chemical binding]; other site
59374002293	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
59374002294	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
59374002295	ABC-2 type transporter; Region: ABC2_membrane; cl17235
59374002296	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
59374002297	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
59374002298	ABC-2 type transporter; Region: ABC2_membrane; cl17235
59374002299	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
59374002300	HlyD family secretion protein; Region: HlyD_3; pfam13437
59374002301	Outer membrane efflux protein; Region: OEP; pfam02321
59374002302	Outer membrane efflux protein; Region: OEP; pfam02321
59374002303	Lamin Tail Domain; Region: LTD; pfam00932
59374002304	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
59374002305	putative metal binding residues [ion binding]; other site
59374002306	signature motif; other site
59374002307	dimer interface [polypeptide binding]; other site
59374002308	active site
59374002309	polyP binding site; other site
59374002310	substrate binding site [chemical binding]; other site
59374002311	acceptor-phosphate pocket; other site
59374002312	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
59374002313	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
59374002314	HlyD family secretion protein; Region: HlyD_3; pfam13437
59374002315	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
59374002316	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
59374002317	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
59374002318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
59374002319	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374002320	TIGR02147 family protein; Region: Fsuc_second
59374002321	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374002322	putative oxidoreductase; Provisional; Region: PRK12831
59374002323	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
59374002324	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59374002325	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
59374002326	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
59374002327	FAD binding pocket [chemical binding]; other site
59374002328	FAD binding motif [chemical binding]; other site
59374002329	phosphate binding motif [ion binding]; other site
59374002330	beta-alpha-beta structure motif; other site
59374002331	NAD binding pocket [chemical binding]; other site
59374002332	Iron coordination center [ion binding]; other site
59374002333	Transcriptional regulator; Region: Rrf2; cl17282
59374002334	Rrf2 family protein; Region: rrf2_super; TIGR00738
59374002335	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374002336	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
59374002337	TPR repeat; Region: TPR_11; pfam13414
59374002338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374002339	binding surface
59374002340	TPR motif; other site
59374002341	TPR repeat; Region: TPR_11; pfam13414
59374002342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374002343	binding surface
59374002344	TPR motif; other site
59374002345	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
59374002346	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
59374002347	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
59374002348	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
59374002349	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
59374002350	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
59374002351	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
59374002352	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
59374002353	Caspase domain; Region: Peptidase_C14; pfam00656
59374002354	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
59374002355	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59374002356	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59374002357	DNA binding residues [nucleotide binding]
59374002358	Nitroreductase family; Region: Nitroreductase; pfam00881
59374002359	FMN binding site [chemical binding]; other site
59374002360	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
59374002361	additional DNA contacts [nucleotide binding]; other site
59374002362	mismatch recognition site; other site
59374002363	active site
59374002364	zinc binding site [ion binding]; other site
59374002365	DNA intercalation site [nucleotide binding]; other site
59374002366	peptidase T; Region: peptidase-T; TIGR01882
59374002367	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
59374002368	metal binding site [ion binding]; metal-binding site
59374002369	dimer interface [polypeptide binding]; other site
59374002370	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
59374002371	transmembrane helices; other site
59374002372	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
59374002373	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
59374002374	TrkA-C domain; Region: TrkA_C; pfam02080
59374002375	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
59374002376	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374002377	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
59374002378	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
59374002379	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
59374002380	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
59374002381	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
59374002382	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
59374002383	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
59374002384	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
59374002385	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
59374002386	active site
59374002387	8-oxo-dGMP binding site [chemical binding]; other site
59374002388	nudix motif; other site
59374002389	metal binding site [ion binding]; metal-binding site
59374002390	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
59374002391	catalytic residues [active]
59374002392	dimer interface [polypeptide binding]; other site
59374002393	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
59374002394	MarR family; Region: MarR; pfam01047
59374002395	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
59374002396	Low molecular weight phosphatase family; Region: LMWPc; cd00115
59374002397	active site
59374002398	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
59374002399	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374002400	putative metal binding site [ion binding]; other site
59374002401	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
59374002402	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59374002403	catalytic residues [active]
59374002404	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
59374002405	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
59374002406	cofactor binding site; other site
59374002407	DNA binding site [nucleotide binding]
59374002408	substrate interaction site [chemical binding]; other site
59374002409	SinI restriction endonuclease; Region: RE_SinI; pfam09570
59374002410	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374002411	non-specific DNA binding site [nucleotide binding]; other site
59374002412	salt bridge; other site
59374002413	sequence-specific DNA binding site [nucleotide binding]; other site
59374002414	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
59374002415	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374002416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374002417	non-specific DNA binding site [nucleotide binding]; other site
59374002418	salt bridge; other site
59374002419	sequence-specific DNA binding site [nucleotide binding]; other site
59374002420	ORF6N domain; Region: ORF6N; pfam10543
59374002421	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
59374002422	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
59374002423	Divergent AAA domain; Region: AAA_4; pfam04326
59374002424	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
59374002425	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
59374002426	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
59374002427	elongation factor Ts; Provisional; Region: tsf; PRK09377
59374002428	UBA/TS-N domain; Region: UBA; pfam00627
59374002429	Elongation factor TS; Region: EF_TS; pfam00889
59374002430	Elongation factor TS; Region: EF_TS; pfam00889
59374002431	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
59374002432	rRNA interaction site [nucleotide binding]; other site
59374002433	S8 interaction site; other site
59374002434	putative laminin-1 binding site; other site
59374002435	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
59374002436	Ligand binding site [chemical binding]; other site
59374002437	Electron transfer flavoprotein domain; Region: ETF; pfam01012
59374002438	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
59374002439	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
59374002440	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
59374002441	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
59374002442	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
59374002443	active site
59374002444	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
59374002445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374002446	Walker A/P-loop; other site
59374002447	ATP binding site [chemical binding]; other site
59374002448	Q-loop/lid; other site
59374002449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374002450	ABC transporter signature motif; other site
59374002451	Walker B; other site
59374002452	D-loop; other site
59374002453	H-loop/switch region; other site
59374002454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374002455	Walker A/P-loop; other site
59374002456	ATP binding site [chemical binding]; other site
59374002457	Q-loop/lid; other site
59374002458	ABC transporter signature motif; other site
59374002459	Walker B; other site
59374002460	D-loop; other site
59374002461	H-loop/switch region; other site
59374002462	radical SAM peptide maturase, FibroRumin system; Region: rSAM_FibroRumin; TIGR04136
59374002463	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374002464	FeS/SAM binding site; other site
59374002465	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
59374002466	PIN domain; Region: PIN_3; pfam13470
59374002467	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
59374002468	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
59374002469	active site
59374002470	ATP binding site [chemical binding]; other site
59374002471	substrate binding site [chemical binding]; other site
59374002472	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
59374002473	putative phosphate binding site [ion binding]; other site
59374002474	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
59374002475	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374002476	Coenzyme A binding pocket [chemical binding]; other site
59374002477	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
59374002478	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
59374002479	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
59374002480	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
59374002481	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59374002482	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374002483	NAD(P) binding site [chemical binding]; other site
59374002484	active site
59374002485	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
59374002486	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
59374002487	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
59374002488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59374002489	motif II; other site
59374002490	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
59374002491	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
59374002492	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
59374002493	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
59374002494	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374002495	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
59374002496	active site
59374002497	nucleotide binding site [chemical binding]; other site
59374002498	HIGH motif; other site
59374002499	KMSKS motif; other site
59374002500	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374002501	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
59374002502	Probable Catalytic site; other site
59374002503	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
59374002504	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
59374002505	Probable Catalytic site; other site
59374002506	metal-binding site
59374002507	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
59374002508	Divergent AAA domain; Region: AAA_4; pfam04326
59374002509	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
59374002510	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
59374002511	putative DNA binding site [nucleotide binding]; other site
59374002512	putative Zn2+ binding site [ion binding]; other site
59374002513	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
59374002514	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59374002515	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
59374002516	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
59374002517	23S rRNA interface [nucleotide binding]; other site
59374002518	L3 interface [polypeptide binding]; other site
59374002519	Domain of unknown function DUF21; Region: DUF21; pfam01595
59374002520	FOG: CBS domain [General function prediction only]; Region: COG0517
59374002521	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
59374002522	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
59374002523	tandem repeat interface [polypeptide binding]; other site
59374002524	oligomer interface [polypeptide binding]; other site
59374002525	active site residues [active]
59374002526	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
59374002527	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
59374002528	tandem repeat interface [polypeptide binding]; other site
59374002529	oligomer interface [polypeptide binding]; other site
59374002530	active site residues [active]
59374002531	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
59374002532	Chain length determinant protein; Region: Wzz; pfam02706
59374002533	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
59374002534	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
59374002535	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59374002536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374002537	NAD(P) binding site [chemical binding]; other site
59374002538	active site
59374002539	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
59374002540	substrate binding site; other site
59374002541	dimer interface; other site
59374002542	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
59374002543	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
59374002544	putative active site [active]
59374002545	catalytic site [active]
59374002546	putative metal binding site [ion binding]; other site
59374002547	oligomer interface [polypeptide binding]; other site
59374002548	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
59374002549	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
59374002550	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
59374002551	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
59374002552	Probable Catalytic site; other site
59374002553	metal-binding site
59374002554	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
59374002555	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
59374002556	LicD family; Region: LicD; cl01378
59374002557	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
59374002558	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374002559	active site
59374002560	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374002561	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59374002562	NAD(P) binding site [chemical binding]; other site
59374002563	active site
59374002564	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
59374002565	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
59374002566	active site
59374002567	metal binding site [ion binding]; metal-binding site
59374002568	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
59374002569	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
59374002570	PYR/PP interface [polypeptide binding]; other site
59374002571	dimer interface [polypeptide binding]; other site
59374002572	TPP binding site [chemical binding]; other site
59374002573	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
59374002574	TPP-binding site; other site
59374002575	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374002576	active site
59374002577	nucleotide binding site [chemical binding]; other site
59374002578	HIGH motif; other site
59374002579	KMSKS motif; other site
59374002580	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
59374002581	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
59374002582	tetramer interface [polypeptide binding]; other site
59374002583	active site
59374002584	Mg2+/Mn2+ binding site [ion binding]; other site
59374002585	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
59374002586	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
59374002587	extended (e) SDRs; Region: SDR_e; cd08946
59374002588	NAD(P) binding site [chemical binding]; other site
59374002589	active site
59374002590	substrate binding site [chemical binding]; other site
59374002591	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
59374002592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59374002593	UDP-galactopyranose mutase; Region: GLF; pfam03275
59374002594	probable UDP-glucose 6-dehydrogenase; Region: PLN02353
59374002595	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
59374002596	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
59374002597	Lamin Tail Domain; Region: LTD; pfam00932
59374002598	CotH protein; Region: CotH; pfam08757
59374002599	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
59374002600	EamA-like transporter family; Region: EamA; cl17759
59374002601	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374002602	TPR motif; other site
59374002603	binding surface
59374002604	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
59374002605	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
59374002606	N-acetyl-D-glucosamine binding site [chemical binding]; other site
59374002607	catalytic residue [active]
59374002608	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
59374002609	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
59374002610	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
59374002611	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
59374002612	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
59374002613	dimerization domain swap beta strand [polypeptide binding]; other site
59374002614	regulatory protein interface [polypeptide binding]; other site
59374002615	active site
59374002616	regulatory phosphorylation site [posttranslational modification]; other site
59374002617	mce related protein; Region: MCE; pfam02470
59374002618	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
59374002619	RNA polymerase beta' subunit; Region: rpoC1; CHL00018
59374002620	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
59374002621	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
59374002622	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
59374002623	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
59374002624	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
59374002625	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
59374002626	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
59374002627	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374002628	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
59374002629	DNA binding site [nucleotide binding]
59374002630	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
59374002631	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59374002632	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
59374002633	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
59374002634	Aerotolerance regulator N-terminal; Region: BatA; cl06567
59374002635	von Willebrand factor type A domain; Region: VWA_2; pfam13519
59374002636	metal ion-dependent adhesion site (MIDAS); other site
59374002637	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374002638	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374002639	metal binding site [ion binding]; metal-binding site
59374002640	active site
59374002641	I-site; other site
59374002642	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374002643	metal ion-dependent adhesion site (MIDAS); other site
59374002644	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
59374002645	AzlC protein; Region: AzlC; cl00570
59374002646	YceG-like family; Region: YceG; pfam02618
59374002647	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
59374002648	dimerization interface [polypeptide binding]; other site
59374002649	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
59374002650	active site
59374002651	nucleophile elbow; other site
59374002652	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
59374002653	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374002654	Walker A motif; other site
59374002655	ATP binding site [chemical binding]; other site
59374002656	Walker B motif; other site
59374002657	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
59374002658	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374002659	Walker A motif; other site
59374002660	ATP binding site [chemical binding]; other site
59374002661	Walker B motif; other site
59374002662	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
59374002663	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
59374002664	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
59374002665	Walker A/P-loop; other site
59374002666	ATP binding site [chemical binding]; other site
59374002667	Q-loop/lid; other site
59374002668	ABC transporter signature motif; other site
59374002669	Walker B; other site
59374002670	D-loop; other site
59374002671	H-loop/switch region; other site
59374002672	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002673	PcrB family; Region: PcrB; pfam01884
59374002674	geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169
59374002675	phosphate binding site [ion binding]; other site
59374002676	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002677	TIGR02147 family protein; Region: Fsuc_second
59374002678	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002679	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002680	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002681	TIGR02147 family protein; Region: Fsuc_second
59374002682	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002683	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002684	TIGR02147 family protein; Region: Fsuc_second
59374002685	GSCFA family; Region: GSCFA; pfam08885
59374002686	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002687	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002688	TIGR02147 family protein; Region: Fsuc_second
59374002689	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
59374002690	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
59374002691	ATP binding site [chemical binding]; other site
59374002692	Mg++ binding site [ion binding]; other site
59374002693	motif III; other site
59374002694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374002695	nucleotide binding region [chemical binding]; other site
59374002696	ATP-binding site [chemical binding]; other site
59374002697	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374002698	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374002699	metal binding site [ion binding]; metal-binding site
59374002700	active site
59374002701	I-site; other site
59374002702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374002703	dimer interface [polypeptide binding]; other site
59374002704	conserved gate region; other site
59374002705	ABC-ATPase subunit interface; other site
59374002706	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
59374002707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374002708	Walker A/P-loop; other site
59374002709	ATP binding site [chemical binding]; other site
59374002710	Q-loop/lid; other site
59374002711	ABC transporter signature motif; other site
59374002712	Walker B; other site
59374002713	D-loop; other site
59374002714	H-loop/switch region; other site
59374002715	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
59374002716	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
59374002717	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374002718	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374002719	non-specific DNA binding site [nucleotide binding]; other site
59374002720	salt bridge; other site
59374002721	sequence-specific DNA binding site [nucleotide binding]; other site
59374002722	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
59374002723	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
59374002724	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
59374002725	motif 1; other site
59374002726	active site
59374002727	motif 2; other site
59374002728	motif 3; other site
59374002729	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
59374002730	DHHA1 domain; Region: DHHA1; pfam02272
59374002731	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
59374002732	active site
59374002733	catalytic residues [active]
59374002734	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
59374002735	Pyruvate formate lyase 1; Region: PFL1; cd01678
59374002736	coenzyme A binding site [chemical binding]; other site
59374002737	active site
59374002738	catalytic residues [active]
59374002739	glycine loop; other site
59374002740	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
59374002741	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374002742	FeS/SAM binding site; other site
59374002743	DEAD-like helicases superfamily; Region: DEXDc; smart00487
59374002744	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374002745	ATP binding site [chemical binding]; other site
59374002746	putative Mg++ binding site [ion binding]; other site
59374002747	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374002748	nucleotide binding region [chemical binding]; other site
59374002749	ATP-binding site [chemical binding]; other site
59374002750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
59374002751	ATP binding site [chemical binding]; other site
59374002752	Mg2+ binding site [ion binding]; other site
59374002753	G-X-G motif; other site
59374002754	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
59374002755	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
59374002756	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
59374002757	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
59374002758	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
59374002759	Walker A motif; other site
59374002760	ATP binding site [chemical binding]; other site
59374002761	Walker B motif; other site
59374002762	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
59374002763	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59374002764	catalytic residues [active]
59374002765	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59374002766	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
59374002767	motif 1; other site
59374002768	dimer interface [polypeptide binding]; other site
59374002769	active site
59374002770	motif 2; other site
59374002771	motif 3; other site
59374002772	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374002773	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
59374002774	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
59374002775	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374002776	catalytic residue [active]
59374002777	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
59374002778	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
59374002779	putative ATP binding site [chemical binding]; other site
59374002780	putative substrate interface [chemical binding]; other site
59374002781	AAA domain; Region: AAA_14; pfam13173
59374002782	AAA domain; Region: AAA_22; pfam13401
59374002783	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
59374002784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374002785	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
59374002786	Walker A motif; other site
59374002787	ATP binding site [chemical binding]; other site
59374002788	Walker B motif; other site
59374002789	arginine finger; other site
59374002790	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374002791	Walker A motif; other site
59374002792	ATP binding site [chemical binding]; other site
59374002793	Walker B motif; other site
59374002794	arginine finger; other site
59374002795	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
59374002796	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
59374002797	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
59374002798	AAA domain; Region: AAA_14; pfam13173
59374002799	Fic/DOC family; Region: Fic; cl00960
59374002800	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
59374002801	PLD-like domain; Region: PLDc_2; pfam13091
59374002802	putative active site [active]
59374002803	catalytic site [active]
59374002804	Predicted transcriptional regulator [Transcription]; Region: COG2378
59374002805	WYL domain; Region: WYL; pfam13280
59374002806	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
59374002807	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59374002808	homodimer interface [polypeptide binding]; other site
59374002809	substrate-cofactor binding pocket; other site
59374002810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002811	catalytic residue [active]
59374002812	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59374002813	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59374002814	dimer interface [polypeptide binding]; other site
59374002815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002816	catalytic residue [active]
59374002817	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
59374002818	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
59374002819	Ligand Binding Site [chemical binding]; other site
59374002820	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
59374002821	TolA protein; Region: tolA_full; TIGR02794
59374002822	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
59374002823	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
59374002824	nitrogenase iron protein; Region: nifH; TIGR01287
59374002825	Nucleotide-binding sites [chemical binding]; other site
59374002826	Walker A motif; other site
59374002827	Switch I region of nucleotide binding site; other site
59374002828	Fe4S4 binding sites [ion binding]; other site
59374002829	Switch II region of nucleotide binding site; other site
59374002830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374002831	Radical SAM superfamily; Region: Radical_SAM; pfam04055
59374002832	FeS/SAM binding site; other site
59374002833	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
59374002834	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
59374002835	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
59374002836	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
59374002837	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
59374002838	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59374002839	homodimer interface [polypeptide binding]; other site
59374002840	substrate-cofactor binding pocket; other site
59374002841	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002842	catalytic residue [active]
59374002843	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59374002844	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59374002845	dimer interface [polypeptide binding]; other site
59374002846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002847	catalytic residue [active]
59374002848	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
59374002849	Leucine carboxyl methyltransferase; Region: LCM; cl01306
59374002850	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
59374002851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374002852	dimer interface [polypeptide binding]; other site
59374002853	conserved gate region; other site
59374002854	putative PBP binding loops; other site
59374002855	ABC-ATPase subunit interface; other site
59374002856	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
59374002857	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
59374002858	Walker A/P-loop; other site
59374002859	ATP binding site [chemical binding]; other site
59374002860	Q-loop/lid; other site
59374002861	ABC transporter signature motif; other site
59374002862	Walker B; other site
59374002863	D-loop; other site
59374002864	H-loop/switch region; other site
59374002865	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
59374002866	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374002867	substrate binding pocket [chemical binding]; other site
59374002868	membrane-bound complex binding site; other site
59374002869	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
59374002870	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
59374002871	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
59374002872	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
59374002873	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
59374002874	nitrogenase iron protein; Region: nifH; TIGR01287
59374002875	Nucleotide-binding sites [chemical binding]; other site
59374002876	Walker A motif; other site
59374002877	Switch I region of nucleotide binding site; other site
59374002878	Fe4S4 binding sites [ion binding]; other site
59374002879	Switch II region of nucleotide binding site; other site
59374002880	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
59374002881	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
59374002882	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
59374002883	Coenzyme A binding pocket [chemical binding]; other site
59374002884	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59374002885	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59374002886	dimer interface [polypeptide binding]; other site
59374002887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002888	catalytic residue [active]
59374002889	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
59374002890	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
59374002891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
59374002892	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
59374002893	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
59374002894	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59374002895	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59374002896	dimer interface [polypeptide binding]; other site
59374002897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002898	catalytic residue [active]
59374002899	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
59374002900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374002901	dimer interface [polypeptide binding]; other site
59374002902	conserved gate region; other site
59374002903	putative PBP binding loops; other site
59374002904	ABC-ATPase subunit interface; other site
59374002905	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
59374002906	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
59374002907	Walker A/P-loop; other site
59374002908	ATP binding site [chemical binding]; other site
59374002909	Q-loop/lid; other site
59374002910	ABC transporter signature motif; other site
59374002911	Walker B; other site
59374002912	D-loop; other site
59374002913	H-loop/switch region; other site
59374002914	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
59374002915	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374002916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002917	homodimer interface [polypeptide binding]; other site
59374002918	catalytic residue [active]
59374002919	Transcriptional regulator [Transcription]; Region: LysR; COG0583
59374002920	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
59374002921	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
59374002922	dimerization interface [polypeptide binding]; other site
59374002923	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
59374002924	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
59374002925	FtsX-like permease family; Region: FtsX; pfam02687
59374002926	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
59374002927	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
59374002928	Walker A/P-loop; other site
59374002929	ATP binding site [chemical binding]; other site
59374002930	Q-loop/lid; other site
59374002931	ABC transporter signature motif; other site
59374002932	Walker B; other site
59374002933	D-loop; other site
59374002934	H-loop/switch region; other site
59374002935	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
59374002936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374002937	S-adenosylmethionine binding site [chemical binding]; other site
59374002938	Fic family protein [Function unknown]; Region: COG3177
59374002939	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
59374002940	Fic/DOC family; Region: Fic; pfam02661
59374002941	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
59374002942	Divergent AAA domain; Region: AAA_4; pfam04326
59374002943	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
59374002944	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
59374002945	putative DNA binding site [nucleotide binding]; other site
59374002946	putative Zn2+ binding site [ion binding]; other site
59374002947	glucokinase, proteobacterial type; Region: glk; TIGR00749
59374002948	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
59374002949	nucleotide binding site [chemical binding]; other site
59374002950	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
59374002951	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
59374002952	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59374002953	putative acyl-acceptor binding pocket; other site
59374002954	RNB domain; Region: RNB; pfam00773
59374002955	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
59374002956	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
59374002957	RNA binding site [nucleotide binding]; other site
59374002958	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
59374002959	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374002960	catalytic core [active]
59374002961	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
59374002962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374002963	S-adenosylmethionine binding site [chemical binding]; other site
59374002964	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
59374002965	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374002966	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
59374002967	hypothetical protein; Provisional; Region: PRK00955
59374002968	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
59374002969	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
59374002970	Na binding site [ion binding]; other site
59374002971	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
59374002972	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
59374002973	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
59374002974	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
59374002975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374002976	Walker A motif; other site
59374002977	ATP binding site [chemical binding]; other site
59374002978	Walker B motif; other site
59374002979	arginine finger; other site
59374002980	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374002981	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
59374002982	EamA-like transporter family; Region: EamA; pfam00892
59374002983	EamA-like transporter family; Region: EamA; pfam00892
59374002984	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
59374002985	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59374002986	homodimer interface [polypeptide binding]; other site
59374002987	substrate-cofactor binding pocket; other site
59374002988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374002989	catalytic residue [active]
59374002990	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
59374002991	Sodium Bile acid symporter family; Region: SBF; pfam01758
59374002992	putative transporter; Validated; Region: PRK03818
59374002993	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
59374002994	TrkA-C domain; Region: TrkA_C; pfam02080
59374002995	TrkA-C domain; Region: TrkA_C; pfam02080
59374002996	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
59374002997	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
59374002998	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
59374002999	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
59374003000	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
59374003001	DNA binding residues [nucleotide binding]
59374003002	putative dimer interface [polypeptide binding]; other site
59374003003	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
59374003004	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
59374003005	nudix motif; other site
59374003006	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
59374003007	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
59374003008	active site
59374003009	nucleophile elbow; other site
59374003010	TIGR02147 family protein; Region: Fsuc_second
59374003011	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374003012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374003013	S-adenosylmethionine binding site [chemical binding]; other site
59374003014	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
59374003015	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
59374003016	homodimer interface [polypeptide binding]; other site
59374003017	putative metal binding site [ion binding]; other site
59374003018	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
59374003019	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
59374003020	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
59374003021	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
59374003022	recombination protein RecR; Reviewed; Region: recR; PRK00076
59374003023	RecR protein; Region: RecR; pfam02132
59374003024	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
59374003025	putative active site [active]
59374003026	putative metal-binding site [ion binding]; other site
59374003027	tetramer interface [polypeptide binding]; other site
59374003028	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
59374003029	G1 box; other site
59374003030	GTP/Mg2+ binding site [chemical binding]; other site
59374003031	Switch I region; other site
59374003032	G2 box; other site
59374003033	G3 box; other site
59374003034	Switch II region; other site
59374003035	G4 box; other site
59374003036	G5 box; other site
59374003037	Permease; Region: Permease; pfam02405
59374003038	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
59374003039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374003040	Walker A/P-loop; other site
59374003041	ATP binding site [chemical binding]; other site
59374003042	Q-loop/lid; other site
59374003043	ABC transporter signature motif; other site
59374003044	Walker B; other site
59374003045	D-loop; other site
59374003046	H-loop/switch region; other site
59374003047	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
59374003048	active site
59374003049	substrate binding pocket [chemical binding]; other site
59374003050	dimer interface [polypeptide binding]; other site
59374003051	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374003052	ligand binding site [chemical binding]; other site
59374003053	TIGR02452 family protein; Region: TIGR02452
59374003054	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
59374003055	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
59374003056	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374003057	Walker A motif; other site
59374003058	ATP binding site [chemical binding]; other site
59374003059	Walker B motif; other site
59374003060	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374003061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003062	Walker A motif; other site
59374003063	ATP binding site [chemical binding]; other site
59374003064	Walker B motif; other site
59374003065	arginine finger; other site
59374003066	Predicted transcriptional regulator [Transcription]; Region: COG2378
59374003067	WYL domain; Region: WYL; pfam13280
59374003068	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
59374003069	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374003070	Zn2+ binding site [ion binding]; other site
59374003071	Mg2+ binding site [ion binding]; other site
59374003072	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
59374003073	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
59374003074	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
59374003075	HIGH motif; other site
59374003076	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
59374003077	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374003078	active site
59374003079	KMSKS motif; other site
59374003080	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
59374003081	tRNA binding surface [nucleotide binding]; other site
59374003082	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
59374003083	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374003084	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374003085	S-adenosylmethionine binding site [chemical binding]; other site
59374003086	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
59374003087	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
59374003088	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
59374003089	substrate binding pocket [chemical binding]; other site
59374003090	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
59374003091	B12 binding site [chemical binding]; other site
59374003092	cobalt ligand [ion binding]; other site
59374003093	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
59374003094	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
59374003095	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
59374003096	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
59374003097	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59374003098	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
59374003099	DNA binding residues [nucleotide binding]
59374003100	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
59374003101	dimer interface [polypeptide binding]; other site
59374003102	Y-family of DNA polymerases; Region: PolY; cl12025
59374003103	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
59374003104	active site
59374003105	DNA binding site [nucleotide binding]
59374003106	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
59374003107	TolA C-terminal; Region: TolA; pfam06519
59374003108	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
59374003109	GAF domain; Region: GAF; pfam01590
59374003110	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374003111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374003112	metal binding site [ion binding]; metal-binding site
59374003113	active site
59374003114	I-site; other site
59374003115	exonuclease SbcC; Region: sbcc; TIGR00618
59374003116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374003117	Walker A/P-loop; other site
59374003118	ATP binding site [chemical binding]; other site
59374003119	Q-loop/lid; other site
59374003120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374003121	ABC transporter signature motif; other site
59374003122	Walker B; other site
59374003123	D-loop; other site
59374003124	H-loop/switch region; other site
59374003125	exonuclease subunit SbcD; Provisional; Region: PRK10966
59374003126	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
59374003127	active site
59374003128	metal binding site [ion binding]; metal-binding site
59374003129	DNA binding site [nucleotide binding]
59374003130	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374003131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374003132	dimer interface [polypeptide binding]; other site
59374003133	phosphorylation site [posttranslational modification]
59374003134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374003135	ATP binding site [chemical binding]; other site
59374003136	Mg2+ binding site [ion binding]; other site
59374003137	G-X-G motif; other site
59374003138	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374003139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374003140	active site
59374003141	phosphorylation site [posttranslational modification]
59374003142	intermolecular recognition site; other site
59374003143	dimerization interface [polypeptide binding]; other site
59374003144	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374003145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374003146	active site
59374003147	phosphorylation site [posttranslational modification]
59374003148	intermolecular recognition site; other site
59374003149	dimerization interface [polypeptide binding]; other site
59374003150	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
59374003151	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
59374003152	Part of AAA domain; Region: AAA_19; pfam13245
59374003153	AAA domain; Region: AAA_30; pfam13604
59374003154	Family description; Region: UvrD_C_2; pfam13538
59374003155	Competence protein CoiA-like family; Region: CoiA; cl11541
59374003156	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
59374003157	Divergent AAA domain; Region: AAA_4; pfam04326
59374003158	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
59374003159	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
59374003160	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
59374003161	BRO family, N-terminal domain; Region: Bro-N; pfam02498
59374003162	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
59374003163	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
59374003164	putative dimer interface [polypeptide binding]; other site
59374003165	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
59374003166	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
59374003167	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
59374003168	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
59374003169	putative DNA binding helix; other site
59374003170	metal binding site 2 [ion binding]; metal-binding site
59374003171	metal binding site 1 [ion binding]; metal-binding site
59374003172	dimer interface [polypeptide binding]; other site
59374003173	structural Zn2+ binding site [ion binding]; other site
59374003174	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
59374003175	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
59374003176	intersubunit interface [polypeptide binding]; other site
59374003177	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
59374003178	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
59374003179	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
59374003180	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
59374003181	ABC-ATPase subunit  interface; other site
59374003182	dimer interface [polypeptide binding]; other site
59374003183	putative PBP binding regions; other site
59374003184	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
59374003185	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
59374003186	Protein of unknown function DUF58; Region: DUF58; pfam01882
59374003187	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374003188	metal ion-dependent adhesion site (MIDAS); other site
59374003189	elongation factor G; Reviewed; Region: PRK13351
59374003190	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
59374003191	G1 box; other site
59374003192	GTP/Mg2+ binding site [chemical binding]; other site
59374003193	G2 box; other site
59374003194	Switch I region; other site
59374003195	G3 box; other site
59374003196	Switch II region; other site
59374003197	G4 box; other site
59374003198	G5 box; other site
59374003199	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
59374003200	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
59374003201	synthetase active site [active]
59374003202	NTP binding site [chemical binding]; other site
59374003203	metal binding site [ion binding]; metal-binding site
59374003204	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
59374003205	HD domain; Region: HD_4; pfam13328
59374003206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
59374003207	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
59374003208	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
59374003209	active site
59374003210	dimer interface [polypeptide binding]; other site
59374003211	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
59374003212	dimer interface [polypeptide binding]; other site
59374003213	active site
59374003214	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374003215	metal binding site [ion binding]; metal-binding site
59374003216	active site
59374003217	I-site; other site
59374003218	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
59374003219	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374003220	catalytic core [active]
59374003221	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374003222	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374003223	MoxR-like ATPases [General function prediction only]; Region: COG0714
59374003224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003225	Walker A motif; other site
59374003226	ATP binding site [chemical binding]; other site
59374003227	Walker B motif; other site
59374003228	arginine finger; other site
59374003229	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
59374003230	BRO family, N-terminal domain; Region: Bro-N; pfam02498
59374003231	TfoX N-terminal domain; Region: TfoX_N; pfam04993
59374003232	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
59374003233	Domain of unknown function (DUF373); Region: DUF373; cl12079
59374003234	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
59374003235	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
59374003236	Oxygen tolerance; Region: BatD; pfam13584
59374003237	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
59374003238	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374003239	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374003240	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374003241	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374003242	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374003243	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
59374003244	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
59374003245	Walker A/P-loop; other site
59374003246	ATP binding site [chemical binding]; other site
59374003247	Q-loop/lid; other site
59374003248	ABC transporter signature motif; other site
59374003249	Walker B; other site
59374003250	D-loop; other site
59374003251	H-loop/switch region; other site
59374003252	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
59374003253	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
59374003254	Walker A/P-loop; other site
59374003255	ATP binding site [chemical binding]; other site
59374003256	Q-loop/lid; other site
59374003257	ABC transporter signature motif; other site
59374003258	Walker B; other site
59374003259	D-loop; other site
59374003260	H-loop/switch region; other site
59374003261	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
59374003262	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
59374003263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374003264	dimer interface [polypeptide binding]; other site
59374003265	conserved gate region; other site
59374003266	putative PBP binding loops; other site
59374003267	ABC-ATPase subunit interface; other site
59374003268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
59374003269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374003270	dimer interface [polypeptide binding]; other site
59374003271	conserved gate region; other site
59374003272	putative PBP binding loops; other site
59374003273	ABC-ATPase subunit interface; other site
59374003274	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
59374003275	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
59374003276	substrate binding site [chemical binding]; other site
59374003277	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
59374003278	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
59374003279	GIY-YIG motif/motif A; other site
59374003280	active site
59374003281	catalytic site [active]
59374003282	putative DNA binding site [nucleotide binding]; other site
59374003283	metal binding site [ion binding]; metal-binding site
59374003284	UvrB/uvrC motif; Region: UVR; pfam02151
59374003285	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
59374003286	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
59374003287	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
59374003288	Beta-lactamase; Region: Beta-lactamase; pfam00144
59374003289	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
59374003290	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
59374003291	mce related protein; Region: MCE; pfam02470
59374003292	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
59374003293	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
59374003294	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
59374003295	Hpr binding site; other site
59374003296	active site
59374003297	homohexamer subunit interaction site [polypeptide binding]; other site
59374003298	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
59374003299	30S subunit binding site; other site
59374003300	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
59374003301	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
59374003302	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
59374003303	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
59374003304	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
59374003305	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
59374003306	Walker A/P-loop; other site
59374003307	ATP binding site [chemical binding]; other site
59374003308	Q-loop/lid; other site
59374003309	ABC transporter signature motif; other site
59374003310	Walker B; other site
59374003311	D-loop; other site
59374003312	H-loop/switch region; other site
59374003313	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
59374003314	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
59374003315	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
59374003316	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
59374003317	dimer interface [polypeptide binding]; other site
59374003318	PYR/PP interface [polypeptide binding]; other site
59374003319	TPP binding site [chemical binding]; other site
59374003320	substrate binding site [chemical binding]; other site
59374003321	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
59374003322	TPP-binding site; other site
59374003323	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
59374003324	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
59374003325	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374003326	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
59374003327	Transglycosylase; Region: Transgly; pfam00912
59374003328	hypothetical protein; Provisional; Region: PRK10621
59374003329	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
59374003330	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
59374003331	GIY-YIG motif/motif A; other site
59374003332	putative active site [active]
59374003333	putative metal binding site [ion binding]; other site
59374003334	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
59374003335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374003336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374003337	dimer interface [polypeptide binding]; other site
59374003338	phosphorylation site [posttranslational modification]
59374003339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374003340	ATP binding site [chemical binding]; other site
59374003341	Mg2+ binding site [ion binding]; other site
59374003342	G-X-G motif; other site
59374003343	Response regulator receiver domain; Region: Response_reg; pfam00072
59374003344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374003345	active site
59374003346	phosphorylation site [posttranslational modification]
59374003347	intermolecular recognition site; other site
59374003348	dimerization interface [polypeptide binding]; other site
59374003349	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
59374003350	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
59374003351	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374003352	active site
59374003353	enolase; Provisional; Region: eno; PRK00077
59374003354	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
59374003355	dimer interface [polypeptide binding]; other site
59374003356	metal binding site [ion binding]; metal-binding site
59374003357	substrate binding pocket [chemical binding]; other site
59374003358	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
59374003359	DNA-binding site [nucleotide binding]; DNA binding site
59374003360	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
59374003361	DNA-binding site [nucleotide binding]; DNA binding site
59374003362	Transcriptional regulators [Transcription]; Region: PurR; COG1609
59374003363	Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377
59374003364	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
59374003365	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
59374003366	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
59374003367	S17 interaction site [polypeptide binding]; other site
59374003368	S8 interaction site; other site
59374003369	16S rRNA interaction site [nucleotide binding]; other site
59374003370	streptomycin interaction site [chemical binding]; other site
59374003371	23S rRNA interaction site [nucleotide binding]; other site
59374003372	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
59374003373	DNA-directed RNA polymerase, gamma subunit; Region: rpoC1_cyan; TIGR02387
59374003374	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
59374003375	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
59374003376	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
59374003377	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
59374003378	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
59374003379	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
59374003380	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
59374003381	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
59374003382	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
59374003383	DNA binding site [nucleotide binding]
59374003384	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
59374003385	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
59374003386	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
59374003387	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
59374003388	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
59374003389	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
59374003390	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
59374003391	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
59374003392	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
59374003393	RPB3 interaction site [polypeptide binding]; other site
59374003394	RPB1 interaction site [polypeptide binding]; other site
59374003395	RPB11 interaction site [polypeptide binding]; other site
59374003396	RPB10 interaction site [polypeptide binding]; other site
59374003397	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
59374003398	core dimer interface [polypeptide binding]; other site
59374003399	peripheral dimer interface [polypeptide binding]; other site
59374003400	L10 interface [polypeptide binding]; other site
59374003401	L11 interface [polypeptide binding]; other site
59374003402	putative EF-Tu interaction site [polypeptide binding]; other site
59374003403	putative EF-G interaction site [polypeptide binding]; other site
59374003404	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
59374003405	23S rRNA interface [nucleotide binding]; other site
59374003406	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
59374003407	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
59374003408	mRNA/rRNA interface [nucleotide binding]; other site
59374003409	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
59374003410	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
59374003411	23S rRNA interface [nucleotide binding]; other site
59374003412	L7/L12 interface [polypeptide binding]; other site
59374003413	putative thiostrepton binding site; other site
59374003414	L25 interface [polypeptide binding]; other site
59374003415	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
59374003416	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
59374003417	putative homodimer interface [polypeptide binding]; other site
59374003418	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
59374003419	heterodimer interface [polypeptide binding]; other site
59374003420	homodimer interface [polypeptide binding]; other site
59374003421	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
59374003422	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
59374003423	elongation factor Tu; Reviewed; Region: PRK00049
59374003424	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
59374003425	G1 box; other site
59374003426	GEF interaction site [polypeptide binding]; other site
59374003427	GTP/Mg2+ binding site [chemical binding]; other site
59374003428	Switch I region; other site
59374003429	G2 box; other site
59374003430	G3 box; other site
59374003431	Switch II region; other site
59374003432	G4 box; other site
59374003433	G5 box; other site
59374003434	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
59374003435	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
59374003436	Antibiotic Binding Site [chemical binding]; other site
59374003437	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
59374003438	active site
59374003439	recombination factor protein RarA; Reviewed; Region: PRK13342
59374003440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003441	Walker A motif; other site
59374003442	ATP binding site [chemical binding]; other site
59374003443	Walker B motif; other site
59374003444	arginine finger; other site
59374003445	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
59374003446	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
59374003447	TIGR02147 family protein; Region: Fsuc_second
59374003448	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374003449	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
59374003450	Adenosylhomocysteinase; Provisional; Region: PTZ00075
59374003451	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
59374003452	homotetramer interface [polypeptide binding]; other site
59374003453	ligand binding site [chemical binding]; other site
59374003454	catalytic site [active]
59374003455	NAD binding site [chemical binding]; other site
59374003456	Virulence protein [General function prediction only]; Region: COG3943
59374003457	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
59374003458	Restriction endonuclease [Defense mechanisms]; Region: COG3587
59374003459	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
59374003460	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
59374003461	Uncharacterized conserved protein [Function unknown]; Region: COG1479
59374003462	Protein of unknown function DUF262; Region: DUF262; pfam03235
59374003463	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
59374003464	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374003465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374003466	non-specific DNA binding site [nucleotide binding]; other site
59374003467	salt bridge; other site
59374003468	sequence-specific DNA binding site [nucleotide binding]; other site
59374003469	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525
59374003470	nucleotide binding site [chemical binding]; other site
59374003471	Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896
59374003472	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
59374003473	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
59374003474	putative active site [active]
59374003475	putative NTP binding site [chemical binding]; other site
59374003476	putative nucleic acid binding site [nucleotide binding]; other site
59374003477	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
59374003478	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374003479	SIR2-like domain; Region: SIR2_2; pfam13289
59374003480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003481	Walker A motif; other site
59374003482	ATP binding site [chemical binding]; other site
59374003483	Walker B motif; other site
59374003484	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
59374003485	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
59374003486	PLD-like domain; Region: PLDc_2; pfam13091
59374003487	homodimer interface [polypeptide binding]; other site
59374003488	putative active site [active]
59374003489	catalytic site [active]
59374003490	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
59374003491	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
59374003492	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
59374003493	putative active site [active]
59374003494	catalytic site [active]
59374003495	DEAD-like helicases superfamily; Region: DEXDc; smart00487
59374003496	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374003497	ATP binding site [chemical binding]; other site
59374003498	putative Mg++ binding site [ion binding]; other site
59374003499	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374003500	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
59374003501	nucleotide binding region [chemical binding]; other site
59374003502	ATP-binding site [chemical binding]; other site
59374003503	von Willebrand factor type A domain; Region: VWA_2; pfam13519
59374003504	metal ion-dependent adhesion site (MIDAS); other site
59374003505	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374003506	active site
59374003507	catalytic triad [active]
59374003508	oxyanion hole [active]
59374003509	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
59374003510	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
59374003511	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
59374003512	active site
59374003513	catalytic triad [active]
59374003514	oxyanion hole [active]
59374003515	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374003516	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
59374003517	active site
59374003518	catalytic triad [active]
59374003519	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374003520	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
59374003521	PEGA domain; Region: PEGA; pfam08308
59374003522	PEGA domain; Region: PEGA; pfam08308
59374003523	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
59374003524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
59374003525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374003526	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
59374003527	active site
59374003528	phosphorylation site [posttranslational modification]
59374003529	intermolecular recognition site; other site
59374003530	dimerization interface [polypeptide binding]; other site
59374003531	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59374003532	DNA binding site [nucleotide binding]
59374003533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374003534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374003535	dimer interface [polypeptide binding]; other site
59374003536	phosphorylation site [posttranslational modification]
59374003537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374003538	ATP binding site [chemical binding]; other site
59374003539	Mg2+ binding site [ion binding]; other site
59374003540	G-X-G motif; other site
59374003541	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
59374003542	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
59374003543	active site
59374003544	ADP/pyrophosphate binding site [chemical binding]; other site
59374003545	dimerization interface [polypeptide binding]; other site
59374003546	allosteric effector site; other site
59374003547	fructose-1,6-bisphosphate binding site; other site
59374003548	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
59374003549	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374003550	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374003551	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
59374003552	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
59374003553	homodimer interface [polypeptide binding]; other site
59374003554	oligonucleotide binding site [chemical binding]; other site
59374003555	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374003556	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374003557	DNA polymerase III subunit beta; Validated; Region: PRK05643
59374003558	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
59374003559	putative DNA binding surface [nucleotide binding]; other site
59374003560	dimer interface [polypeptide binding]; other site
59374003561	beta-clamp/clamp loader binding surface; other site
59374003562	beta-clamp/translesion DNA polymerase binding surface; other site
59374003563	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
59374003564	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
59374003565	Ligand Binding Site [chemical binding]; other site
59374003566	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374003567	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
59374003568	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
59374003569	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
59374003570	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
59374003571	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
59374003572	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
59374003573	HsdM N-terminal domain; Region: HsdM_N; pfam12161
59374003574	Methyltransferase domain; Region: Methyltransf_26; pfam13659
59374003575	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
59374003576	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
59374003577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374003578	ATP binding site [chemical binding]; other site
59374003579	putative Mg++ binding site [ion binding]; other site
59374003580	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
59374003581	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
59374003582	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
59374003583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
59374003584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
59374003585	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
59374003586	dimerization interface [polypeptide binding]; other site
59374003587	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
59374003588	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
59374003589	THF binding site; other site
59374003590	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
59374003591	substrate binding site [chemical binding]; other site
59374003592	THF binding site; other site
59374003593	zinc-binding site [ion binding]; other site
59374003594	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
59374003595	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
59374003596	dimer interface [polypeptide binding]; other site
59374003597	pyridoxal binding site [chemical binding]; other site
59374003598	ATP binding site [chemical binding]; other site
59374003599	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
59374003600	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374003601	FeS/SAM binding site; other site
59374003602	von Willebrand factor type A domain; Region: VWA_2; pfam13519
59374003603	metal ion-dependent adhesion site (MIDAS); other site
59374003604	RNase III inhibitor; Provisional; Region: PRK00431
59374003605	ADP-ribose binding site [chemical binding]; other site
59374003606	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003607	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
59374003608	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003609	LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563
59374003610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
59374003611	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
59374003612	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003613	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003614	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003615	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003616	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003617	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003618	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003619	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374003620	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
59374003621	Rubredoxin; Region: Rubredoxin; pfam00301
59374003622	iron binding site [ion binding]; other site
59374003623	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
59374003624	Carbon starvation protein CstA; Region: CstA; pfam02554
59374003625	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
59374003626	aspartate kinase; Reviewed; Region: PRK09034
59374003627	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
59374003628	nucleotide binding site [chemical binding]; other site
59374003629	substrate binding site [chemical binding]; other site
59374003630	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
59374003631	allosteric regulatory residue; other site
59374003632	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
59374003633	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003634	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
59374003635	Walker A motif; other site
59374003636	ATP binding site [chemical binding]; other site
59374003637	Walker B motif; other site
59374003638	arginine finger; other site
59374003639	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374003640	Protein of unknown function (DUF3308); Region: DUF3308; cl14675
59374003641	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
59374003642	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
59374003643	active site
59374003644	substrate binding site [chemical binding]; other site
59374003645	metal binding site [ion binding]; metal-binding site
59374003646	HipA-like N-terminal domain; Region: HipA_N; pfam07805
59374003647	HipA-like C-terminal domain; Region: HipA_C; pfam07804
59374003648	HipA N-terminal domain; Region: Couple_hipA; pfam13657
59374003649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374003650	non-specific DNA binding site [nucleotide binding]; other site
59374003651	salt bridge; other site
59374003652	sequence-specific DNA binding site [nucleotide binding]; other site
59374003653	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
59374003654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374003655	S-adenosylmethionine binding site [chemical binding]; other site
59374003656	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
59374003657	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
59374003658	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
59374003659	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59374003660	catalytic residue [active]
59374003661	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
59374003662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003663	Walker A motif; other site
59374003664	ATP binding site [chemical binding]; other site
59374003665	Walker B motif; other site
59374003666	arginine finger; other site
59374003667	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
59374003668	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
59374003669	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
59374003670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374003671	Walker A motif; other site
59374003672	ATP binding site [chemical binding]; other site
59374003673	Walker B motif; other site
59374003674	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
59374003675	Clp protease; Region: CLP_protease; pfam00574
59374003676	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
59374003677	oligomer interface [polypeptide binding]; other site
59374003678	active site residues [active]
59374003679	trigger factor; Region: tig; TIGR00115
59374003680	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374003681	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
59374003682	Methyltransferase domain; Region: Methyltransf_23; pfam13489
59374003683	Methyltransferase domain; Region: Methyltransf_11; pfam08241
59374003684	S-adenosylmethionine binding site [chemical binding]; other site
59374003685	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
59374003686	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
59374003687	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
59374003688	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
59374003689	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
59374003690	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
59374003691	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
59374003692	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
59374003693	alphaNTD homodimer interface [polypeptide binding]; other site
59374003694	alphaNTD - beta interaction site [polypeptide binding]; other site
59374003695	alphaNTD - beta' interaction site [polypeptide binding]; other site
59374003696	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
59374003697	30S ribosomal protein S11; Validated; Region: PRK05309
59374003698	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
59374003699	30S ribosomal protein S13; Region: bact_S13; TIGR03631
59374003700	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
59374003701	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
59374003702	rRNA binding site [nucleotide binding]; other site
59374003703	predicted 30S ribosome binding site; other site
59374003704	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
59374003705	SecY translocase; Region: SecY; pfam00344
59374003706	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
59374003707	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
59374003708	23S rRNA binding site [nucleotide binding]; other site
59374003709	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
59374003710	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
59374003711	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
59374003712	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
59374003713	5S rRNA interface [nucleotide binding]; other site
59374003714	L27 interface [polypeptide binding]; other site
59374003715	23S rRNA interface [nucleotide binding]; other site
59374003716	L5 interface [polypeptide binding]; other site
59374003717	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
59374003718	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
59374003719	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
59374003720	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
59374003721	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
59374003722	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
59374003723	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
59374003724	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
59374003725	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
59374003726	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
59374003727	RNA binding site [nucleotide binding]; other site
59374003728	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
59374003729	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
59374003730	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
59374003731	putative translocon interaction site; other site
59374003732	23S rRNA interface [nucleotide binding]; other site
59374003733	signal recognition particle (SRP54) interaction site; other site
59374003734	L23 interface [polypeptide binding]; other site
59374003735	trigger factor interaction site; other site
59374003736	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
59374003737	23S rRNA interface [nucleotide binding]; other site
59374003738	5S rRNA interface [nucleotide binding]; other site
59374003739	putative antibiotic binding site [chemical binding]; other site
59374003740	L25 interface [polypeptide binding]; other site
59374003741	L27 interface [polypeptide binding]; other site
59374003742	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
59374003743	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
59374003744	G-X-X-G motif; other site
59374003745	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
59374003746	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
59374003747	putative translocon binding site; other site
59374003748	protein-rRNA interface [nucleotide binding]; other site
59374003749	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
59374003750	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
59374003751	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
59374003752	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
59374003753	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
59374003754	50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953
59374003755	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
59374003756	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
59374003757	elongation factor Tu; Reviewed; Region: PRK00049
59374003758	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
59374003759	G1 box; other site
59374003760	GEF interaction site [polypeptide binding]; other site
59374003761	GTP/Mg2+ binding site [chemical binding]; other site
59374003762	Switch I region; other site
59374003763	G2 box; other site
59374003764	G3 box; other site
59374003765	Switch II region; other site
59374003766	G4 box; other site
59374003767	G5 box; other site
59374003768	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
59374003769	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
59374003770	Antibiotic Binding Site [chemical binding]; other site
59374003771	Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015
59374003772	Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015
59374003773	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374003774	sequence-specific DNA binding site [nucleotide binding]; other site
59374003775	salt bridge; other site
59374003776	Peptidase family M48; Region: Peptidase_M48; cl12018
59374003777	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
59374003778	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374003779	WYL domain; Region: WYL; pfam13280
59374003780	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
59374003781	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
59374003782	putative trimer interface [polypeptide binding]; other site
59374003783	putative CoA binding site [chemical binding]; other site
59374003784	Hereditary spastic paraplegia protein strumpellin; Region: Strumpellin; pfam10266
59374003785	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
59374003786	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
59374003787	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
59374003788	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
59374003789	active site
59374003790	metal binding site [ion binding]; metal-binding site
59374003791	hexamer interface [polypeptide binding]; other site
59374003792	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
59374003793	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374003794	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374003795	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
59374003796	ParB-like nuclease domain; Region: ParB; smart00470
59374003797	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
59374003798	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
59374003799	P-loop; other site
59374003800	Magnesium ion binding site [ion binding]; other site
59374003801	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
59374003802	Magnesium ion binding site [ion binding]; other site
59374003803	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
59374003804	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
59374003805	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
59374003806	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
59374003807	putative metal binding site [ion binding]; other site
59374003808	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
59374003809	putative ADP-ribose binding site [chemical binding]; other site
59374003810	putative active site [active]
59374003811	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
59374003812	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
59374003813	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
59374003814	LemA family; Region: LemA; cl00742
59374003815	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
59374003816	Sodium Bile acid symporter family; Region: SBF; pfam01758
59374003817	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
59374003818	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
59374003819	active site
59374003820	NAD binding site [chemical binding]; other site
59374003821	metal binding site [ion binding]; metal-binding site
59374003822	Tetratricopeptide repeat; Region: TPR_12; pfam13424
59374003823	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374003824	binding surface
59374003825	TPR motif; other site
59374003826	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
59374003827	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
59374003828	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374003829	ATP binding site [chemical binding]; other site
59374003830	putative Mg++ binding site [ion binding]; other site
59374003831	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
59374003832	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374003833	nucleotide binding region [chemical binding]; other site
59374003834	ATP-binding site [chemical binding]; other site
59374003835	SEC-C motif; Region: SEC-C; pfam02810
59374003836	thymidylate kinase; Validated; Region: tmk; PRK00698
59374003837	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
59374003838	TMP-binding site; other site
59374003839	ATP-binding site [chemical binding]; other site
59374003840	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
59374003841	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
59374003842	active site
59374003843	metal binding site [ion binding]; metal-binding site
59374003844	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
59374003845	active site
59374003846	NTP binding site [chemical binding]; other site
59374003847	metal binding triad [ion binding]; metal-binding site
59374003848	antibiotic binding site [chemical binding]; other site
59374003849	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
59374003850	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
59374003851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
59374003852	binding surface
59374003853	TPR motif; other site
59374003854	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59374003855	LabA_like proteins; Region: LabA_like; cd06167
59374003856	putative metal binding site [ion binding]; other site
59374003857	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
59374003858	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
59374003859	intersubunit interface [polypeptide binding]; other site
59374003860	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59374003861	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
59374003862	ligand binding site [chemical binding]; other site
59374003863	flexible hinge region; other site
59374003864	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
59374003865	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
59374003866	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
59374003867	dimerization interface [polypeptide binding]; other site
59374003868	putative ATP binding site [chemical binding]; other site
59374003869	Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015
59374003870	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374003871	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374003872	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
59374003873	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374003874	ABC transporter; Region: ABC_tran_2; pfam12848
59374003875	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374003876	regulatory ATPase RavA; Provisional; Region: PRK13531
59374003877	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
59374003878	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
59374003879	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
59374003880	Tetramer interface [polypeptide binding]; other site
59374003881	active site
59374003882	FMN-binding site [chemical binding]; other site
59374003883	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
59374003884	Rubredoxin; Region: Rubredoxin; pfam00301
59374003885	iron binding site [ion binding]; other site
59374003886	Rubrerythrin [Energy production and conversion]; Region: COG1592
59374003887	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
59374003888	diiron binding motif [ion binding]; other site
59374003889	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
59374003890	metal binding site 2 [ion binding]; metal-binding site
59374003891	putative DNA binding helix; other site
59374003892	metal binding site 1 [ion binding]; metal-binding site
59374003893	dimer interface [polypeptide binding]; other site
59374003894	structural Zn2+ binding site [ion binding]; other site
59374003895	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
59374003896	TrkA-N domain; Region: TrkA_N; pfam02254
59374003897	TrkA-C domain; Region: TrkA_C; pfam02080
59374003898	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
59374003899	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
59374003900	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374003901	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
59374003902	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
59374003903	ABC transporter ATPase component; Reviewed; Region: PRK11147
59374003904	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374003905	Walker A/P-loop; other site
59374003906	ATP binding site [chemical binding]; other site
59374003907	Q-loop/lid; other site
59374003908	ABC transporter signature motif; other site
59374003909	Walker B; other site
59374003910	D-loop; other site
59374003911	H-loop/switch region; other site
59374003912	ABC transporter; Region: ABC_tran_2; pfam12848
59374003913	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374003914	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374003915	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
59374003916	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
59374003917	propionate/acetate kinase; Provisional; Region: PRK12379
59374003918	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
59374003919	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
59374003920	active site
59374003921	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374003922	catalytic core [active]
59374003923	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
59374003924	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
59374003925	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
59374003926	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
59374003927	homodimer interface [polypeptide binding]; other site
59374003928	NADP binding site [chemical binding]; other site
59374003929	substrate binding site [chemical binding]; other site
59374003930	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
59374003931	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
59374003932	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374003933	N-acetylglutamate synthase; Validated; Region: PRK05279
59374003934	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
59374003935	nucleotide binding site [chemical binding]; other site
59374003936	substrate binding site [chemical binding]; other site
59374003937	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374003938	Coenzyme A binding pocket [chemical binding]; other site
59374003939	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
59374003940	FMN binding site [chemical binding]; other site
59374003941	dimer interface [polypeptide binding]; other site
59374003942	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374003943	TIGR02147 family protein; Region: Fsuc_second
59374003944	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
59374003945	homodecamer interface [polypeptide binding]; other site
59374003946	GTP cyclohydrolase I; Provisional; Region: PLN03044
59374003947	active site
59374003948	putative catalytic site residues [active]
59374003949	zinc binding site [ion binding]; other site
59374003950	GTP-CH-I/GFRP interaction surface; other site
59374003951	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
59374003952	Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740
59374003953	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
59374003954	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
59374003955	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
59374003956	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
59374003957	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
59374003958	DsbD alpha interface [polypeptide binding]; other site
59374003959	catalytic residues [active]
59374003960	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
59374003961	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59374003962	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
59374003963	DNA binding residues [nucleotide binding]
59374003964	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
59374003965	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
59374003966	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
59374003967	active site
59374003968	NTP binding site [chemical binding]; other site
59374003969	metal binding triad [ion binding]; metal-binding site
59374003970	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
59374003971	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
59374003972	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
59374003973	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374003974	active site
59374003975	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
59374003976	acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852
59374003977	active site
59374003978	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374003979	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
59374003980	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
59374003981	active site
59374003982	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
59374003983	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374003984	aminodeoxychorismate synthase; Provisional; Region: PRK07508
59374003985	chorismate binding enzyme; Region: Chorismate_bind; cl10555
59374003986	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
59374003987	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
59374003988	substrate-cofactor binding pocket; other site
59374003989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374003990	catalytic residue [active]
59374003991	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
59374003992	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
59374003993	substrate binding site [chemical binding]; other site
59374003994	hexamer interface [polypeptide binding]; other site
59374003995	metal binding site [ion binding]; metal-binding site
59374003996	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
59374003997	diaminopimelate decarboxylase; Provisional; Region: PRK11165
59374003998	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
59374003999	active site
59374004000	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59374004001	substrate binding site [chemical binding]; other site
59374004002	catalytic residues [active]
59374004003	dimer interface [polypeptide binding]; other site
59374004004	Catalytic domain of Protein Kinases; Region: PKc; cd00180
59374004005	active site
59374004006	ATP binding site [chemical binding]; other site
59374004007	substrate binding site [chemical binding]; other site
59374004008	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
59374004009	substrate binding site [chemical binding]; other site
59374004010	activation loop (A-loop); other site
59374004011	activation loop (A-loop); other site
59374004012	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374004013	metal ion-dependent adhesion site (MIDAS); other site
59374004014	Protein phosphatase 2C; Region: PP2C_2; pfam13672
59374004015	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
59374004016	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374004017	FeS/SAM binding site; other site
59374004018	AAA domain; Region: AAA_23; pfam13476
59374004019	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
59374004020	G1 box; other site
59374004021	GTP/Mg2+ binding site [chemical binding]; other site
59374004022	G2 box; other site
59374004023	Switch I region; other site
59374004024	G3 box; other site
59374004025	Switch II region; other site
59374004026	G4 box; other site
59374004027	G5 box; other site
59374004028	Predicted GTPase [General function prediction only]; Region: COG3596
59374004029	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
59374004030	G1 box; other site
59374004031	GTP/Mg2+ binding site [chemical binding]; other site
59374004032	G2 box; other site
59374004033	Switch I region; other site
59374004034	G3 box; other site
59374004035	Switch II region; other site
59374004036	G4 box; other site
59374004037	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
59374004038	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
59374004039	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
59374004040	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09668
59374004041	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
59374004042	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
59374004043	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
59374004044	CRISPR-associated protein; Region: TIGR03986
59374004045	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
59374004046	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
59374004047	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
59374004048	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
59374004049	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
59374004050	active site
59374004051	substrate binding site [chemical binding]; other site
59374004052	metal binding site [ion binding]; metal-binding site
59374004053	Cna protein B-type domain; Region: Cna_B_2; pfam13715
59374004054	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374004055	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374004056	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374004057	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
59374004058	LabA_like proteins; Region: LabA_like/DUF88; cl10034
59374004059	putative metal binding site [ion binding]; other site
59374004060	Uncharacterized conserved protein [Function unknown]; Region: COG1432
59374004061	OST-HTH/LOTUS domain; Region: OST-HTH; pfam12872
59374004062	Outer membrane efflux protein; Region: OEP; pfam02321
59374004063	Outer membrane efflux protein; Region: OEP; pfam02321
59374004064	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
59374004065	active site
59374004066	phosphorylation site [posttranslational modification]
59374004067	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
59374004068	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
59374004069	active site
59374004070	catalytic residue [active]
59374004071	dimer interface [polypeptide binding]; other site
59374004072	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
59374004073	Clp protease; Region: CLP_protease; pfam00574
59374004074	oligomer interface [polypeptide binding]; other site
59374004075	active site residues [active]
59374004076	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
59374004077	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
59374004078	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
59374004079	P loop; other site
59374004080	GTP binding site [chemical binding]; other site
59374004081	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59374004082	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
59374004083	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
59374004084	DXD motif; other site
59374004085	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
59374004086	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374004087	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
59374004088	Response regulator receiver domain; Region: Response_reg; pfam00072
59374004089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004090	active site
59374004091	phosphorylation site [posttranslational modification]
59374004092	intermolecular recognition site; other site
59374004093	dimerization interface [polypeptide binding]; other site
59374004094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374004095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374004096	metal binding site [ion binding]; metal-binding site
59374004097	active site
59374004098	I-site; other site
59374004099	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
59374004100	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
59374004101	active site
59374004102	intersubunit interface [polypeptide binding]; other site
59374004103	catalytic residue [active]
59374004104	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
59374004105	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
59374004106	FtsX-like permease family; Region: FtsX; pfam02687
59374004107	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
59374004108	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
59374004109	Walker A/P-loop; other site
59374004110	ATP binding site [chemical binding]; other site
59374004111	Q-loop/lid; other site
59374004112	ABC transporter signature motif; other site
59374004113	Walker B; other site
59374004114	D-loop; other site
59374004115	H-loop/switch region; other site
59374004116	tyrosine kinase; Provisional; Region: PRK11519
59374004117	Chain length determinant protein; Region: Wzz; pfam02706
59374004118	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
59374004119	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
59374004120	P-loop; other site
59374004121	Magnesium ion binding site [ion binding]; other site
59374004122	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374004123	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374004124	ligand binding site [chemical binding]; other site
59374004125	GtrA-like protein; Region: GtrA; pfam04138
59374004126	Predicted membrane protein [Function unknown]; Region: COG2246
59374004127	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
59374004128	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
59374004129	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
59374004130	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374004131	catalytic core [active]
59374004132	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374004133	catalytic core [active]
59374004134	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
59374004135	carboxyltransferase (CT) interaction site; other site
59374004136	biotinylation site [posttranslational modification]; other site
59374004137	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
59374004138	TIGR02147 family protein; Region: Fsuc_second
59374004139	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004140	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004141	TIGR02147 family protein; Region: Fsuc_second
59374004142	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004143	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004144	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004145	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004146	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004147	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004148	Archaeal ATPase; Region: Arch_ATPase; pfam01637
59374004149	TIGR02147 family protein; Region: Fsuc_second
59374004150	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004151	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004152	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004153	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004154	TIGR02147 family protein; Region: Fsuc_second
59374004155	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004156	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004157	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004158	Cache domain; Region: Cache_1; pfam02743
59374004159	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
59374004160	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
59374004161	dimerization interface [polypeptide binding]; other site
59374004162	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
59374004163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
59374004164	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
59374004165	phosphate binding site [ion binding]; other site
59374004166	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
59374004167	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
59374004168	active site
59374004169	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
59374004170	active site 2 [active]
59374004171	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
59374004172	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
59374004173	hinge; other site
59374004174	active site
59374004175	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
59374004176	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
59374004177	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
59374004178	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
59374004179	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
59374004180	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
59374004181	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
59374004182	GDP-binding site [chemical binding]; other site
59374004183	ACT binding site; other site
59374004184	IMP binding site; other site
59374004185	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59374004186	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
59374004187	ligand binding site [chemical binding]; other site
59374004188	flexible hinge region; other site
59374004189	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
59374004190	putative switch regulator; other site
59374004191	non-specific DNA interactions [nucleotide binding]; other site
59374004192	DNA binding site [nucleotide binding]
59374004193	sequence specific DNA binding site [nucleotide binding]; other site
59374004194	putative cAMP binding site [chemical binding]; other site
59374004195	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
59374004196	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
59374004197	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
59374004198	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
59374004199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
59374004200	TPR motif; other site
59374004201	binding surface
59374004202	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
59374004203	Family description; Region: VCBS; pfam13517
59374004204	Family description; Region: VCBS; pfam13517
59374004205	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374004206	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374004207	NlpE N-terminal domain; Region: NlpE; pfam04170
59374004208	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
59374004209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004210	active site
59374004211	phosphorylation site [posttranslational modification]
59374004212	intermolecular recognition site; other site
59374004213	dimerization interface [polypeptide binding]; other site
59374004214	LytTr DNA-binding domain; Region: LytTR; smart00850
59374004215	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
59374004216	Catalytic site [active]
59374004217	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
59374004218	Bacterial Ig-like domain; Region: Big_5; pfam13205
59374004219	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
59374004220	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
59374004221	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
59374004222	active site
59374004223	catalytic site [active]
59374004224	substrate binding site [chemical binding]; other site
59374004225	DEAD/DEAH box helicase; Region: DEAD; pfam00270
59374004226	ATP binding site [chemical binding]; other site
59374004227	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
59374004228	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374004229	active site
59374004230	catalytic triad [active]
59374004231	oxyanion hole [active]
59374004232	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374004233	metal binding site [ion binding]; metal-binding site
59374004234	active site
59374004235	I-site; other site
59374004236	TIGR02147 family protein; Region: Fsuc_second
59374004237	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
59374004238	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
59374004239	substrate binding pocket [chemical binding]; other site
59374004240	chain length determination region; other site
59374004241	substrate-Mg2+ binding site; other site
59374004242	catalytic residues [active]
59374004243	aspartate-rich region 1; other site
59374004244	active site lid residues [active]
59374004245	aspartate-rich region 2; other site
59374004246	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
59374004247	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
59374004248	TPP-binding site; other site
59374004249	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
59374004250	PYR/PP interface [polypeptide binding]; other site
59374004251	dimer interface [polypeptide binding]; other site
59374004252	TPP binding site [chemical binding]; other site
59374004253	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
59374004254	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
59374004255	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59374004256	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
59374004257	active site
59374004258	dimer interface [polypeptide binding]; other site
59374004259	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
59374004260	mce related protein; Region: MCE; pfam02470
59374004261	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
59374004262	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
59374004263	active site
59374004264	metal binding site [ion binding]; metal-binding site
59374004265	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
59374004266	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374004267	Predicted integral membrane protein [Function unknown]; Region: COG5542
59374004268	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
59374004269	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
59374004270	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374004271	binding surface
59374004272	TPR motif; other site
59374004273	TPR repeat; Region: TPR_11; pfam13414
59374004274	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374004275	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
59374004276	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
59374004277	DXD motif; other site
59374004278	xanthine permease; Region: pbuX; TIGR03173
59374004279	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374004280	active site
59374004281	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374004282	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
59374004283	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
59374004284	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
59374004285	Active Sites [active]
59374004286	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
59374004287	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
59374004288	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
59374004289	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374004290	catalytic residue [active]
59374004291	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
59374004292	PLD-like domain; Region: PLDc_2; pfam13091
59374004293	putative active site [active]
59374004294	catalytic site [active]
59374004295	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
59374004296	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
59374004297	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374004298	putative Mg++ binding site [ion binding]; other site
59374004299	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374004300	ATP-binding site [chemical binding]; other site
59374004301	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
59374004302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374004303	Walker A/P-loop; other site
59374004304	ATP binding site [chemical binding]; other site
59374004305	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
59374004306	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
59374004307	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59374004308	DNA binding residues [nucleotide binding]
59374004309	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
59374004310	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
59374004311	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
59374004312	FeoA domain; Region: FeoA; pfam04023
59374004313	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
59374004314	ferrous iron transporter FeoB; Region: feoB; TIGR00437
59374004315	G1 box; other site
59374004316	GTP/Mg2+ binding site [chemical binding]; other site
59374004317	Switch I region; other site
59374004318	G2 box; other site
59374004319	G3 box; other site
59374004320	Switch II region; other site
59374004321	G4 box; other site
59374004322	G5 box; other site
59374004323	Nucleoside recognition; Region: Gate; pfam07670
59374004324	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
59374004325	Nucleoside recognition; Region: Gate; pfam07670
59374004326	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
59374004327	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374004328	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
59374004329	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
59374004330	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
59374004331	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59374004332	motif II; other site
59374004333	Fic family protein [Function unknown]; Region: COG3177
59374004334	Fic/DOC family; Region: Fic; pfam02661
59374004335	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
59374004336	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
59374004337	Protein export membrane protein; Region: SecD_SecF; cl14618
59374004338	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
59374004339	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
59374004340	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
59374004341	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
59374004342	Walker A/P-loop; other site
59374004343	ATP binding site [chemical binding]; other site
59374004344	Q-loop/lid; other site
59374004345	ABC transporter signature motif; other site
59374004346	Walker B; other site
59374004347	D-loop; other site
59374004348	H-loop/switch region; other site
59374004349	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
59374004350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374004351	Walker A/P-loop; other site
59374004352	ATP binding site [chemical binding]; other site
59374004353	Q-loop/lid; other site
59374004354	ABC transporter signature motif; other site
59374004355	Walker B; other site
59374004356	D-loop; other site
59374004357	H-loop/switch region; other site
59374004358	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
59374004359	Ca binding site [ion binding]; other site
59374004360	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
59374004361	TIGR02147 family protein; Region: Fsuc_second
59374004362	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
59374004363	Uncharacterized conserved protein [Function unknown]; Region: COG1262
59374004364	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374004365	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374004366	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
59374004367	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
59374004368	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
59374004369	maltose O-acetyltransferase; Provisional; Region: PRK10092
59374004370	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
59374004371	active site
59374004372	substrate binding site [chemical binding]; other site
59374004373	trimer interface [polypeptide binding]; other site
59374004374	CoA binding site [chemical binding]; other site
59374004375	Phosphate transporter family; Region: PHO4; pfam01384
59374004376	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
59374004377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004378	active site
59374004379	phosphorylation site [posttranslational modification]
59374004380	intermolecular recognition site; other site
59374004381	dimerization interface [polypeptide binding]; other site
59374004382	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59374004383	DNA binding site [nucleotide binding]
59374004384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374004385	dimer interface [polypeptide binding]; other site
59374004386	phosphorylation site [posttranslational modification]
59374004387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374004388	ATP binding site [chemical binding]; other site
59374004389	Mg2+ binding site [ion binding]; other site
59374004390	G-X-G motif; other site
59374004391	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
59374004392	PhoU domain; Region: PhoU; pfam01895
59374004393	PhoU domain; Region: PhoU; pfam01895
59374004394	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
59374004395	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
59374004396	Walker A/P-loop; other site
59374004397	ATP binding site [chemical binding]; other site
59374004398	Q-loop/lid; other site
59374004399	ABC transporter signature motif; other site
59374004400	Walker B; other site
59374004401	D-loop; other site
59374004402	H-loop/switch region; other site
59374004403	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
59374004404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374004405	dimer interface [polypeptide binding]; other site
59374004406	conserved gate region; other site
59374004407	putative PBP binding loops; other site
59374004408	ABC-ATPase subunit interface; other site
59374004409	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
59374004410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374004411	dimer interface [polypeptide binding]; other site
59374004412	conserved gate region; other site
59374004413	putative PBP binding loops; other site
59374004414	ABC-ATPase subunit interface; other site
59374004415	PBP superfamily domain; Region: PBP_like_2; cl17296
59374004416	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
59374004417	PBP superfamily domain; Region: PBP_like_2; cl17296
59374004418	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59374004419	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
59374004420	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
59374004421	active site
59374004422	catalytic tetrad [active]
59374004423	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
59374004424	AAA domain; Region: AAA_14; pfam13173
59374004425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
59374004426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
59374004427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
59374004428	dimerization interface [polypeptide binding]; other site
59374004429	Uncharacterized conserved protein [Function unknown]; Region: COG1359
59374004430	Uncharacterized conserved protein [Function unknown]; Region: COG4925
59374004431	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
59374004432	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
59374004433	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
59374004434	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59374004435	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
59374004436	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
59374004437	DEAD-like helicases superfamily; Region: DEXDc; smart00487
59374004438	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374004439	ATP binding site [chemical binding]; other site
59374004440	putative Mg++ binding site [ion binding]; other site
59374004441	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
59374004442	nucleotide binding region [chemical binding]; other site
59374004443	ATP-binding site [chemical binding]; other site
59374004444	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
59374004445	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
59374004446	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
59374004447	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
59374004448	HsdM N-terminal domain; Region: HsdM_N; pfam12161
59374004449	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
59374004450	Methyltransferase domain; Region: Methyltransf_26; pfam13659
59374004451	Transcriptional regulator [Transcription]; Region: LysR; COG0583
59374004452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
59374004453	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
59374004454	dimerization interface [polypeptide binding]; other site
59374004455	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
59374004456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374004457	Coenzyme A binding pocket [chemical binding]; other site
59374004458	Archaeal ATPase; Region: Arch_ATPase; pfam01637
59374004459	AAA domain; Region: AAA_14; pfam13173
59374004460	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
59374004461	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
59374004462	ZIP Zinc transporter; Region: Zip; pfam02535
59374004463	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
59374004464	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
59374004465	Methyltransferase domain; Region: Methyltransf_31; pfam13847
59374004466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374004467	S-adenosylmethionine binding site [chemical binding]; other site
59374004468	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59374004469	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59374004470	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374004471	Walker A/P-loop; other site
59374004472	ATP binding site [chemical binding]; other site
59374004473	Q-loop/lid; other site
59374004474	ABC transporter signature motif; other site
59374004475	Walker B; other site
59374004476	D-loop; other site
59374004477	H-loop/switch region; other site
59374004478	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59374004479	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59374004480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374004481	Walker A/P-loop; other site
59374004482	ATP binding site [chemical binding]; other site
59374004483	Q-loop/lid; other site
59374004484	ABC transporter signature motif; other site
59374004485	Walker B; other site
59374004486	D-loop; other site
59374004487	H-loop/switch region; other site
59374004488	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
59374004489	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
59374004490	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
59374004491	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
59374004492	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
59374004493	G1 box; other site
59374004494	GTP/Mg2+ binding site [chemical binding]; other site
59374004495	Switch I region; other site
59374004496	G2 box; other site
59374004497	G3 box; other site
59374004498	Switch II region; other site
59374004499	G4 box; other site
59374004500	G5 box; other site
59374004501	Nucleoside recognition; Region: Gate; pfam07670
59374004502	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
59374004503	Nucleoside recognition; Region: Gate; pfam07670
59374004504	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
59374004505	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
59374004506	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
59374004507	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
59374004508	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
59374004509	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
59374004510	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
59374004511	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
59374004512	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
59374004513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
59374004514	Cache domain; Region: Cache_1; pfam02743
59374004515	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
59374004516	dimerization interface [polypeptide binding]; other site
59374004517	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374004518	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374004519	metal binding site [ion binding]; metal-binding site
59374004520	active site
59374004521	I-site; other site
59374004522	Cache domain; Region: Cache_1; pfam02743
59374004523	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
59374004524	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
59374004525	dimerization interface [polypeptide binding]; other site
59374004526	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374004527	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374004528	metal binding site [ion binding]; metal-binding site
59374004529	active site
59374004530	I-site; other site
59374004531	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
59374004532	DivIVA protein; Region: DivIVA; pfam05103
59374004533	DivIVA domain; Region: DivI1A_domain; TIGR03544
59374004534	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
59374004535	Ribonuclease P; Region: Ribonuclease_P; pfam00825
59374004536	Haemolytic domain; Region: Haemolytic; pfam01809
59374004537	membrane protein insertase; Provisional; Region: PRK01318
59374004538	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
59374004539	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
59374004540	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
59374004541	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
59374004542	dimer interface [polypeptide binding]; other site
59374004543	catalytic triad [active]
59374004544	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
59374004545	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374004546	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374004547	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374004548	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004549	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004550	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004551	Domain of unknown function (DUF4423); Region: DUF4423; pfam14394
59374004552	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
59374004553	active site
59374004554	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374004555	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004556	putative metal binding site [ion binding]; other site
59374004557	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
59374004558	active site
59374004559	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374004560	ligand binding site [chemical binding]; other site
59374004561	metal binding site [ion binding]; metal-binding site
59374004562	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004563	putative metal binding site [ion binding]; other site
59374004564	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
59374004565	substrate binding site [chemical binding]; other site
59374004566	active site
59374004567	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374004568	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004569	putative metal binding site [ion binding]; other site
59374004570	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
59374004571	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
59374004572	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004573	putative metal binding site [ion binding]; other site
59374004574	Domain of unknown function (DUF303); Region: DUF303; pfam03629
59374004575	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004576	putative metal binding site [ion binding]; other site
59374004577	Domain of unknown function (DUF303); Region: DUF303; pfam03629
59374004578	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004579	putative metal binding site [ion binding]; other site
59374004580	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374004581	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
59374004582	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
59374004583	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
59374004584	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
59374004585	active site
59374004586	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004587	putative metal binding site [ion binding]; other site
59374004588	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
59374004589	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
59374004590	alpha-galactosidase; Region: PLN02808; cl17638
59374004591	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004592	putative metal binding site [ion binding]; other site
59374004593	Right handed beta helix region; Region: Beta_helix; pfam13229
59374004594	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004595	putative metal binding site [ion binding]; other site
59374004596	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
59374004597	substrate binding site [chemical binding]; other site
59374004598	active site
59374004599	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374004600	metal binding site [ion binding]; metal-binding site
59374004601	ligand binding site [chemical binding]; other site
59374004602	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004603	putative metal binding site [ion binding]; other site
59374004604	HipA N-terminal domain; Region: Couple_hipA; pfam13657
59374004605	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
59374004606	HipA-like N-terminal domain; Region: HipA_N; pfam07805
59374004607	HipA-like C-terminal domain; Region: HipA_C; pfam07804
59374004608	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374004609	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374004610	non-specific DNA binding site [nucleotide binding]; other site
59374004611	salt bridge; other site
59374004612	sequence-specific DNA binding site [nucleotide binding]; other site
59374004613	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374004614	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374004615	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
59374004616	Part of AAA domain; Region: AAA_19; pfam13245
59374004617	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
59374004618	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
59374004619	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
59374004620	Protein of unknown function DUF262; Region: DUF262; pfam03235
59374004621	Uncharacterized conserved protein [Function unknown]; Region: COG1479
59374004622	Protein of unknown function DUF262; Region: DUF262; pfam03235
59374004623	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
59374004624	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
59374004625	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
59374004626	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
59374004627	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
59374004628	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
59374004629	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
59374004630	Ca binding site [ion binding]; other site
59374004631	ligand binding site I [chemical binding]; other site
59374004632	homodimer interface [polypeptide binding]; other site
59374004633	ligand binding site II [chemical binding]; other site
59374004634	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374004635	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004636	putative metal binding site [ion binding]; other site
59374004637	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
59374004638	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004639	putative metal binding site [ion binding]; other site
59374004640	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
59374004641	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004642	putative metal binding site [ion binding]; other site
59374004643	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
59374004644	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374004645	putative metal binding site [ion binding]; other site
59374004646	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374004647	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374004648	dimer interface [polypeptide binding]; other site
59374004649	phosphorylation site [posttranslational modification]
59374004650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374004651	ATP binding site [chemical binding]; other site
59374004652	Mg2+ binding site [ion binding]; other site
59374004653	G-X-G motif; other site
59374004654	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374004655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004656	active site
59374004657	phosphorylation site [posttranslational modification]
59374004658	intermolecular recognition site; other site
59374004659	dimerization interface [polypeptide binding]; other site
59374004660	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374004661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004662	active site
59374004663	phosphorylation site [posttranslational modification]
59374004664	intermolecular recognition site; other site
59374004665	dimerization interface [polypeptide binding]; other site
59374004666	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
59374004667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004668	active site
59374004669	phosphorylation site [posttranslational modification]
59374004670	intermolecular recognition site; other site
59374004671	dimerization interface [polypeptide binding]; other site
59374004672	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374004673	Zn2+ binding site [ion binding]; other site
59374004674	Mg2+ binding site [ion binding]; other site
59374004675	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374004676	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374004677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374004678	dimer interface [polypeptide binding]; other site
59374004679	phosphorylation site [posttranslational modification]
59374004680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374004681	ATP binding site [chemical binding]; other site
59374004682	Mg2+ binding site [ion binding]; other site
59374004683	G-X-G motif; other site
59374004684	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374004685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004686	active site
59374004687	phosphorylation site [posttranslational modification]
59374004688	intermolecular recognition site; other site
59374004689	dimerization interface [polypeptide binding]; other site
59374004690	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
59374004691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004692	active site
59374004693	phosphorylation site [posttranslational modification]
59374004694	intermolecular recognition site; other site
59374004695	dimerization interface [polypeptide binding]; other site
59374004696	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374004697	Zn2+ binding site [ion binding]; other site
59374004698	Mg2+ binding site [ion binding]; other site
59374004699	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374004700	substrate binding pocket [chemical binding]; other site
59374004701	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
59374004702	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374004703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374004704	dimer interface [polypeptide binding]; other site
59374004705	phosphorylation site [posttranslational modification]
59374004706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374004707	ATP binding site [chemical binding]; other site
59374004708	Mg2+ binding site [ion binding]; other site
59374004709	G-X-G motif; other site
59374004710	Response regulator receiver domain; Region: Response_reg; pfam00072
59374004711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374004712	active site
59374004713	phosphorylation site [posttranslational modification]
59374004714	intermolecular recognition site; other site
59374004715	dimerization interface [polypeptide binding]; other site
59374004716	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
59374004717	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
59374004718	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
59374004719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59374004720	putative substrate translocation pore; other site
59374004721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59374004722	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
59374004723	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
59374004724	HIGH motif; other site
59374004725	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
59374004726	active site
59374004727	KMSKS motif; other site
59374004728	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
59374004729	tRNA binding surface [nucleotide binding]; other site
59374004730	anticodon binding site; other site
59374004731	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004732	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
59374004733	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
59374004734	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
59374004735	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
59374004736	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
59374004737	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374004738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374004739	homodimer interface [polypeptide binding]; other site
59374004740	catalytic residue [active]
59374004741	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
59374004742	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
59374004743	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374004744	Walker A motif; other site
59374004745	ATP binding site [chemical binding]; other site
59374004746	Walker B motif; other site
59374004747	arginine finger; other site
59374004748	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374004749	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
59374004750	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
59374004751	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
59374004752	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
59374004753	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
59374004754	active site
59374004755	dimer interface [polypeptide binding]; other site
59374004756	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
59374004757	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
59374004758	active site
59374004759	FMN binding site [chemical binding]; other site
59374004760	substrate binding site [chemical binding]; other site
59374004761	3Fe-4S cluster binding site [ion binding]; other site
59374004762	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
59374004763	domain interface; other site
59374004764	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
59374004765	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59374004766	NAD synthetase; Reviewed; Region: nadE; PRK02628
59374004767	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
59374004768	multimer interface [polypeptide binding]; other site
59374004769	active site
59374004770	catalytic triad [active]
59374004771	protein interface 1 [polypeptide binding]; other site
59374004772	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
59374004773	homodimer interface [polypeptide binding]; other site
59374004774	NAD binding pocket [chemical binding]; other site
59374004775	ATP binding pocket [chemical binding]; other site
59374004776	Mg binding site [ion binding]; other site
59374004777	active-site loop [active]
59374004778	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
59374004779	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
59374004780	Nitrogen regulatory protein P-II; Region: P-II; smart00938
59374004781	CTP synthetase; Validated; Region: pyrG; PRK05380
59374004782	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
59374004783	Catalytic site [active]
59374004784	active site
59374004785	UTP binding site [chemical binding]; other site
59374004786	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
59374004787	active site
59374004788	putative oxyanion hole; other site
59374004789	catalytic triad [active]
59374004790	A new structural DNA glycosylase; Region: AlkD_like; cd06561
59374004791	active site
59374004792	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
59374004793	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
59374004794	Z1 domain; Region: Z1; pfam10593
59374004795	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
59374004796	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
59374004797	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374004798	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374004799	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
59374004800	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
59374004801	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
59374004802	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
59374004803	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374004804	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
59374004805	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
59374004806	active site
59374004807	ATP binding site [chemical binding]; other site
59374004808	substrate binding site [chemical binding]; other site
59374004809	activation loop (A-loop); other site
59374004810	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
59374004811	cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904
59374004812	nucleotide binding site [chemical binding]; other site
59374004813	putative NEF/HSP70 interaction site [polypeptide binding]; other site
59374004814	SBD interface [polypeptide binding]; other site
59374004815	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
59374004816	PIN domain; Region: PIN_3; pfam13470
59374004817	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
59374004818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
59374004819	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
59374004820	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004821	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
59374004822	M6 family metalloprotease domain; Region: M6dom_TIGR03296
59374004823	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
59374004824	putative nucleotide binding site [chemical binding]; other site
59374004825	uridine monophosphate binding site [chemical binding]; other site
59374004826	homohexameric interface [polypeptide binding]; other site
59374004827	Domain of unknown function (DUF4421); Region: DUF4421; pfam14391
59374004828	ribosome recycling factor; Reviewed; Region: frr; PRK00083
59374004829	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
59374004830	hinge region; other site
59374004831	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
59374004832	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
59374004833	catalytic residue [active]
59374004834	putative FPP diphosphate  binding site; other site
59374004835	putative FPP binding hydrophobic cleft; other site
59374004836	dimer interface [polypeptide binding]; other site
59374004837	putative IPP diphosphate binding site; other site
59374004838	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
59374004839	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
59374004840	Uncharacterized conserved protein [Function unknown]; Region: COG1262
59374004841	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374004842	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
59374004843	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
59374004844	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
59374004845	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
59374004846	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
59374004847	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
59374004848	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
59374004849	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
59374004850	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
59374004851	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
59374004852	RIP metalloprotease RseP; Region: TIGR00054
59374004853	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
59374004854	active site
59374004855	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
59374004856	protein binding site [polypeptide binding]; other site
59374004857	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
59374004858	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
59374004859	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
59374004860	putative substrate binding region [chemical binding]; other site
59374004861	putative substrate binding region [chemical binding]; other site
59374004862	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
59374004863	RDD family; Region: RDD; pfam06271
59374004864	TSCPD domain; Region: TSCPD; cl14834
59374004865	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59374004866	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
59374004867	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374004868	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
59374004869	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
59374004870	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374004871	Coenzyme A binding pocket [chemical binding]; other site
59374004872	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
59374004873	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
59374004874	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
59374004875	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
59374004876	AIR carboxylase; Region: AIRC; pfam00731
59374004877	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
59374004878	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
59374004879	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
59374004880	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374004881	FeS/SAM binding site; other site
59374004882	Sporulation related domain; Region: SPOR; pfam05036
59374004883	Cache domain; Region: Cache_1; pfam02743
59374004884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
59374004885	dimerization interface [polypeptide binding]; other site
59374004886	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
59374004887	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
59374004888	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
59374004889	Yqey-like protein; Region: YqeY; pfam09424
59374004890	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
59374004891	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
59374004892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374004893	Walker A motif; other site
59374004894	ATP binding site [chemical binding]; other site
59374004895	Walker B motif; other site
59374004896	arginine finger; other site
59374004897	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374004898	Transcriptional regulator [Transcription]; Region: LysR; COG0583
59374004899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
59374004900	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
59374004901	dimerization interface [polypeptide binding]; other site
59374004902	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
59374004903	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
59374004904	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
59374004905	active site
59374004906	HIGH motif; other site
59374004907	dimer interface [polypeptide binding]; other site
59374004908	KMSKS motif; other site
59374004909	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59374004910	RNA binding surface [nucleotide binding]; other site
59374004911	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
59374004912	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
59374004913	substrate binding site [chemical binding]; other site
59374004914	ATP binding site [chemical binding]; other site
59374004915	futalosine nucleosidase; Region: fut_nucase; TIGR03664
59374004916	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
59374004917	Cytochrome P450; Region: p450; cl12078
59374004918	Right handed beta helix region; Region: Beta_helix; pfam13229
59374004919	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374004920	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374004921	ligand binding site [chemical binding]; other site
59374004922	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
59374004923	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
59374004924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374004925	binding surface
59374004926	TPR motif; other site
59374004927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374004928	binding surface
59374004929	TPR motif; other site
59374004930	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
59374004931	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
59374004932	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
59374004933	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
59374004934	rod shape-determining protein MreB; Provisional; Region: PRK13927
59374004935	MreB and similar proteins; Region: MreB_like; cd10225
59374004936	nucleotide binding site [chemical binding]; other site
59374004937	Mg binding site [ion binding]; other site
59374004938	putative protofilament interaction site [polypeptide binding]; other site
59374004939	RodZ interaction site [polypeptide binding]; other site
59374004940	rod shape-determining protein MreC; Provisional; Region: PRK13922
59374004941	rod shape-determining protein MreC; Region: MreC; pfam04085
59374004942	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
59374004943	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
59374004944	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
59374004945	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
59374004946	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
59374004947	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
59374004948	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
59374004949	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
59374004950	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374004951	Zn2+ binding site [ion binding]; other site
59374004952	Mg2+ binding site [ion binding]; other site
59374004953	Lamin Tail Domain; Region: LTD; pfam00932
59374004954	Fn3 associated; Region: Fn3_assoc; pfam13287
59374004955	CotH protein; Region: CotH; pfam08757
59374004956	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
59374004957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374004958	S-adenosylmethionine binding site [chemical binding]; other site
59374004959	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
59374004960	Flavoprotein; Region: Flavoprotein; pfam02441
59374004961	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
59374004962	UbiA prenyltransferase family; Region: UbiA; pfam01040
59374004963	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374004964	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374004965	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
59374004966	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
59374004967	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
59374004968	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
59374004969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
59374004970	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
59374004971	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
59374004972	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374004973	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374004974	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
59374004975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
59374004976	Walker A motif; other site
59374004977	ATP binding site [chemical binding]; other site
59374004978	DNA polymerase III subunit delta'; Validated; Region: PRK05917
59374004979	DNA polymerase III subunit delta'; Validated; Region: PRK08485
59374004980	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
59374004981	DHH family; Region: DHH; pfam01368
59374004982	DHHA1 domain; Region: DHHA1; pfam02272
59374004983	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
59374004984	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374004985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
59374004986	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
59374004987	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
59374004988	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
59374004989	TIGR02147 family protein; Region: Fsuc_second
59374004990	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
59374004991	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
59374004992	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
59374004993	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
59374004994	active site
59374004995	homodimer interface [polypeptide binding]; other site
59374004996	catalytic site [active]
59374004997	acceptor binding site [chemical binding]; other site
59374004998	Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015
59374004999	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
59374005000	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
59374005001	ATP binding site [chemical binding]; other site
59374005002	Mg++ binding site [ion binding]; other site
59374005003	motif III; other site
59374005004	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374005005	nucleotide binding region [chemical binding]; other site
59374005006	ATP-binding site [chemical binding]; other site
59374005007	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
59374005008	putative RNA binding site [nucleotide binding]; other site
59374005009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374005010	Walker A/P-loop; other site
59374005011	ATP binding site [chemical binding]; other site
59374005012	ABC transporter; Region: ABC_tran; pfam00005
59374005013	Q-loop/lid; other site
59374005014	ABC transporter signature motif; other site
59374005015	Walker B; other site
59374005016	D-loop; other site
59374005017	H-loop/switch region; other site
59374005018	Phospholipid methyltransferase; Region: PEMT; cl17370
59374005019	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
59374005020	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
59374005021	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
59374005022	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
59374005023	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
59374005024	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
59374005025	active site
59374005026	catalytic site [active]
59374005027	substrate binding site [chemical binding]; other site
59374005028	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
59374005029	putative acyl-acceptor binding pocket; other site
59374005030	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
59374005031	A new structural DNA glycosylase; Region: AlkD_like; cl11434
59374005032	active site
59374005033	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
59374005034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374005035	FeS/SAM binding site; other site
59374005036	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374005037	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005038	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374005039	ABC transporter signature motif; other site
59374005040	Walker B; other site
59374005041	D-loop; other site
59374005042	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
59374005043	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374005044	Walker A/P-loop; other site
59374005045	ATP binding site [chemical binding]; other site
59374005046	Q-loop/lid; other site
59374005047	ABC transporter signature motif; other site
59374005048	Walker B; other site
59374005049	D-loop; other site
59374005050	H-loop/switch region; other site
59374005051	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
59374005052	Domain of unknown function DUF59; Region: DUF59; pfam01883
59374005053	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
59374005054	Protein of unknown function (DUF971); Region: DUF971; pfam06155
59374005055	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59374005056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59374005057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59374005058	DNA binding residues [nucleotide binding]
59374005059	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374005060	TPR motif; other site
59374005061	binding surface
59374005062	WW domain-binding protein 1; Region: WBP-1; pfam11669
59374005063	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
59374005064	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
59374005065	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
59374005066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59374005067	peptide chain release factor 1; Validated; Region: prfA; PRK00591
59374005068	This domain is found in peptide chain release factors; Region: PCRF; smart00937
59374005069	RF-1 domain; Region: RF-1; pfam00472
59374005070	Thymidylate synthase complementing protein; Region: Thy1; cl03630
59374005071	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
59374005072	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
59374005073	homodimer interaction site [polypeptide binding]; other site
59374005074	cofactor binding site; other site
59374005075	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
59374005076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374005077	NAD(P) binding site [chemical binding]; other site
59374005078	active site
59374005079	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
59374005080	dimer interface [polypeptide binding]; other site
59374005081	ADP-ribose binding site [chemical binding]; other site
59374005082	active site
59374005083	nudix motif; other site
59374005084	metal binding site [ion binding]; metal-binding site
59374005085	TIGR02147 family protein; Region: Fsuc_second
59374005086	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
59374005087	putative active site [active]
59374005088	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
59374005089	NAD binding site [chemical binding]; other site
59374005090	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
59374005091	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
59374005092	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
59374005093	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
59374005094	phosphopeptide binding site; other site
59374005095	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005096	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005097	metal binding site [ion binding]; metal-binding site
59374005098	active site
59374005099	I-site; other site
59374005100	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374005101	Sporulation related domain; Region: SPOR; pfam05036
59374005102	Part of AAA domain; Region: AAA_19; pfam13245
59374005103	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
59374005104	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
59374005105	active site
59374005106	HIGH motif; other site
59374005107	nucleotide binding site [chemical binding]; other site
59374005108	active site
59374005109	KMSKS motif; other site
59374005110	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
59374005111	active site
59374005112	catalytic site [active]
59374005113	substrate binding site [chemical binding]; other site
59374005114	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
59374005115	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
59374005116	DNA topoisomerase III; Validated; Region: PRK08173
59374005117	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
59374005118	active site
59374005119	putative interdomain interaction site [polypeptide binding]; other site
59374005120	putative metal-binding site [ion binding]; other site
59374005121	putative nucleotide binding site [chemical binding]; other site
59374005122	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
59374005123	domain I; other site
59374005124	DNA binding groove [nucleotide binding]
59374005125	phosphate binding site [ion binding]; other site
59374005126	domain II; other site
59374005127	domain III; other site
59374005128	nucleotide binding site [chemical binding]; other site
59374005129	catalytic site [active]
59374005130	domain IV; other site
59374005131	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
59374005132	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
59374005133	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
59374005134	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374005135	active site
59374005136	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
59374005137	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
59374005138	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
59374005139	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374005140	Pectate lyase; Region: Pec_lyase_C; cl01593
59374005141	TIGR02147 family protein; Region: Fsuc_second
59374005142	Right handed beta helix region; Region: Beta_helix; pfam13229
59374005143	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
59374005144	active site
59374005145	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374005146	Ca binding site [ion binding]; other site
59374005147	Ca binding site (active) [ion binding]; other site
59374005148	ligand binding site [chemical binding]; other site
59374005149	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
59374005150	active site
59374005151	catalytic triad [active]
59374005152	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005153	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
59374005154	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374005155	Ca binding site [ion binding]; other site
59374005156	Ca binding site (active) [ion binding]; other site
59374005157	ligand binding site [chemical binding]; other site
59374005158	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
59374005159	substrate binding site [chemical binding]; other site
59374005160	active site
59374005161	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
59374005162	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
59374005163	substrate binding site [chemical binding]; other site
59374005164	active site
59374005165	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
59374005166	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
59374005167	substrate binding site [chemical binding]; other site
59374005168	active site
59374005169	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
59374005170	Ca binding site [ion binding]; other site
59374005171	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374005172	ligand binding site [chemical binding]; other site
59374005173	metal binding site [ion binding]; metal-binding site
59374005174	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374005175	TIGR02147 family protein; Region: Fsuc_second
59374005176	CotH protein; Region: CotH; pfam08757
59374005177	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
59374005178	metal binding site [ion binding]; metal-binding site
59374005179	active site
59374005180	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005181	TIGR02147 family protein; Region: Fsuc_second
59374005182	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
59374005183	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374005184	TIGR02147 family protein; Region: Fsuc_second
59374005185	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374005186	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374005187	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374005188	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
59374005189	Pectate lyase; Region: Pec_lyase_C; cl01593
59374005190	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
59374005191	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
59374005192	putative phosphate acyltransferase; Provisional; Region: PRK05331
59374005193	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
59374005194	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
59374005195	NAD(P) binding site [chemical binding]; other site
59374005196	homotetramer interface [polypeptide binding]; other site
59374005197	homodimer interface [polypeptide binding]; other site
59374005198	active site
59374005199	acyl carrier protein; Provisional; Region: acpP; PRK00982
59374005200	ribonuclease III; Reviewed; Region: rnc; PRK00102
59374005201	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
59374005202	dimerization interface [polypeptide binding]; other site
59374005203	active site
59374005204	metal binding site [ion binding]; metal-binding site
59374005205	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
59374005206	dsRNA binding site [nucleotide binding]; other site
59374005207	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
59374005208	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
59374005209	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005210	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
59374005211	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
59374005212	transmembrane helices; other site
59374005213	hypothetical protein; Provisional; Region: PRK11479
59374005214	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
59374005215	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
59374005216	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
59374005217	HlyD family secretion protein; Region: HlyD_2; pfam12700
59374005218	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
59374005219	HlyD family secretion protein; Region: HlyD_3; pfam13437
59374005220	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
59374005221	Cation efflux family; Region: Cation_efflux; pfam01545
59374005222	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
59374005223	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
59374005224	active site
59374005225	catalytic tetrad [active]
59374005226	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374005227	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
59374005228	active site
59374005229	catalytic residues [active]
59374005230	metal binding site [ion binding]; metal-binding site
59374005231	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
59374005232	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374005233	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005234	Protein kinase; unclassified specificity; Region: STYKc; smart00221
59374005235	Catalytic domain of Protein Kinases; Region: PKc; cd00180
59374005236	active site
59374005237	ATP binding site [chemical binding]; other site
59374005238	substrate binding site [chemical binding]; other site
59374005239	activation loop (A-loop); other site
59374005240	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
59374005241	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
59374005242	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
59374005243	B12 binding site [chemical binding]; other site
59374005244	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
59374005245	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
59374005246	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005247	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005248	metal binding site [ion binding]; metal-binding site
59374005249	active site
59374005250	I-site; other site
59374005251	AAA domain; Region: AAA_14; pfam13173
59374005252	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
59374005253	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374005254	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
59374005255	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
59374005256	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374005257	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
59374005258	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
59374005259	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
59374005260	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374005261	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374005262	active site
59374005263	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374005264	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
59374005265	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
59374005266	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374005267	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
59374005268	active site
59374005269	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
59374005270	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
59374005271	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
59374005272	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
59374005273	Radical SAM superfamily; Region: Radical_SAM; pfam04055
59374005274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374005275	FeS/SAM binding site; other site
59374005276	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
59374005277	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
59374005278	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
59374005279	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
59374005280	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
59374005281	Ligand binding site; other site
59374005282	Putative Catalytic site; other site
59374005283	DXD motif; other site
59374005284	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
59374005285	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
59374005286	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374005287	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
59374005288	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
59374005289	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59374005290	inhibitor-cofactor binding pocket; inhibition site
59374005291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374005292	catalytic residue [active]
59374005293	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
59374005294	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
59374005295	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
59374005296	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
59374005297	putative DNA binding site [nucleotide binding]; other site
59374005298	putative Zn2+ binding site [ion binding]; other site
59374005299	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374005300	non-specific DNA binding site [nucleotide binding]; other site
59374005301	salt bridge; other site
59374005302	sequence-specific DNA binding site [nucleotide binding]; other site
59374005303	Domain of unknown function (DUF955); Region: DUF955; pfam06114
59374005304	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374005305	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
59374005306	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
59374005307	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
59374005308	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374005309	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
59374005310	glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095
59374005311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59374005312	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
59374005313	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
59374005314	recombination protein F; Reviewed; Region: recF; PRK00064
59374005315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374005316	Walker A/P-loop; other site
59374005317	ATP binding site [chemical binding]; other site
59374005318	Q-loop/lid; other site
59374005319	ABC transporter signature motif; other site
59374005320	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374005321	ABC transporter signature motif; other site
59374005322	Walker B; other site
59374005323	D-loop; other site
59374005324	H-loop/switch region; other site
59374005325	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
59374005326	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
59374005327	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
59374005328	EamA-like transporter family; Region: EamA; cl17759
59374005329	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
59374005330	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
59374005331	CoA-binding site [chemical binding]; other site
59374005332	ATP-binding [chemical binding]; other site
59374005333	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
59374005334	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374005335	Domain of unknown function (DUF4423); Region: DUF4423; pfam14394
59374005336	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
59374005337	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
59374005338	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
59374005339	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
59374005340	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
59374005341	active site
59374005342	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
59374005343	Domain of unknown function (DUF955); Region: DUF955; pfam06114
59374005344	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
59374005345	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
59374005346	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
59374005347	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
59374005348	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
59374005349	active site
59374005350	dimer interface [polypeptide binding]; other site
59374005351	motif 1; other site
59374005352	motif 2; other site
59374005353	motif 3; other site
59374005354	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
59374005355	anticodon binding site; other site
59374005356	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005358	metal binding site [ion binding]; metal-binding site
59374005359	active site
59374005360	I-site; other site
59374005361	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374005362	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374005363	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
59374005364	Rubredoxin; Region: Rubredoxin; pfam00301
59374005365	iron binding site [ion binding]; other site
59374005366	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
59374005367	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
59374005368	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
59374005369	active site
59374005370	catalytic residues [active]
59374005371	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
59374005372	putative deacylase active site [active]
59374005373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005375	metal binding site [ion binding]; metal-binding site
59374005376	active site
59374005377	I-site; other site
59374005378	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
59374005379	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
59374005380	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
59374005381	homodimer interface [polypeptide binding]; other site
59374005382	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
59374005383	active site pocket [active]
59374005384	WYL domain; Region: WYL; pfam13280
59374005385	Virulence protein [General function prediction only]; Region: COG3943
59374005386	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
59374005387	HNH endonuclease; Region: HNH_2; pfam13391
59374005388	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
59374005389	homodimer interface [polypeptide binding]; other site
59374005390	putative active site [active]
59374005391	catalytic site [active]
59374005392	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
59374005393	putative active site [active]
59374005394	ORF6N domain; Region: ORF6N; pfam10543
59374005395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374005396	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374005397	Walker A motif; other site
59374005398	ATP binding site [chemical binding]; other site
59374005399	Walker B motif; other site
59374005400	arginine finger; other site
59374005401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374005402	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374005403	Walker A motif; other site
59374005404	ATP binding site [chemical binding]; other site
59374005405	Walker B motif; other site
59374005406	arginine finger; other site
59374005407	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
59374005408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59374005409	Coenzyme A binding pocket [chemical binding]; other site
59374005410	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374005411	catalytic core [active]
59374005412	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
59374005413	NADH(P)-binding; Region: NAD_binding_10; pfam13460
59374005414	NAD binding site [chemical binding]; other site
59374005415	active site
59374005416	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
59374005417	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
59374005418	Na binding site [ion binding]; other site
59374005419	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
59374005420	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
59374005421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374005422	FeS/SAM binding site; other site
59374005423	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
59374005424	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
59374005425	Cl- selectivity filter; other site
59374005426	Cl- binding residues [ion binding]; other site
59374005427	pore gating glutamate residue; other site
59374005428	dimer interface [polypeptide binding]; other site
59374005429	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
59374005430	CotH protein; Region: CotH; pfam08757
59374005431	ACT domain-containing protein [General function prediction only]; Region: COG4747
59374005432	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
59374005433	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
59374005434	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
59374005435	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374005436	acyl-activating enzyme (AAE) consensus motif; other site
59374005437	AMP binding site [chemical binding]; other site
59374005438	active site
59374005439	CoA binding site [chemical binding]; other site
59374005440	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59374005441	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59374005442	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59374005443	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59374005444	Surface antigen; Region: Bac_surface_Ag; pfam01103
59374005445	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
59374005446	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
59374005447	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59374005448	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
59374005449	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
59374005450	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
59374005451	TIGR02147 family protein; Region: Fsuc_second
59374005452	NADH dehydrogenase subunit B; Validated; Region: PRK06411
59374005453	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
59374005454	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
59374005455	NADH dehydrogenase subunit D; Validated; Region: PRK06075
59374005456	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
59374005457	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
59374005458	putative dimer interface [polypeptide binding]; other site
59374005459	[2Fe-2S] cluster binding site [ion binding]; other site
59374005460	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
59374005461	SLBB domain; Region: SLBB; pfam10531
59374005462	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
59374005463	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
59374005464	catalytic loop [active]
59374005465	iron binding site [ion binding]; other site
59374005466	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
59374005467	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
59374005468	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
59374005469	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
59374005470	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
59374005471	NADH dehydrogenase; Region: NADHdh; cl00469
59374005472	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
59374005473	4Fe-4S binding domain; Region: Fer4; pfam00037
59374005474	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
59374005475	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
59374005476	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
59374005477	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
59374005478	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
59374005479	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59374005480	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
59374005481	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59374005482	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
59374005483	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59374005484	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
59374005485	homotrimer interaction site [polypeptide binding]; other site
59374005486	zinc binding site [ion binding]; other site
59374005487	CDP-binding sites; other site
59374005488	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
59374005489	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
59374005490	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
59374005491	PhoU domain; Region: PhoU; pfam01895
59374005492	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005493	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
59374005494	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
59374005495	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374005496	ATP binding site [chemical binding]; other site
59374005497	putative Mg++ binding site [ion binding]; other site
59374005498	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374005499	nucleotide binding region [chemical binding]; other site
59374005500	ATP-binding site [chemical binding]; other site
59374005501	Rhomboid family; Region: Rhomboid; pfam01694
59374005502	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
59374005503	active site
59374005504	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
59374005505	Predicted permeases [General function prediction only]; Region: COG0795
59374005506	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
59374005507	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
59374005508	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
59374005509	Predicted permeases [General function prediction only]; Region: COG0795
59374005510	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
59374005511	GAF domain; Region: GAF_2; pfam13185
59374005512	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
59374005513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005514	metal binding site [ion binding]; metal-binding site
59374005515	active site
59374005516	I-site; other site
59374005517	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
59374005518	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
59374005519	Na binding site [ion binding]; other site
59374005520	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
59374005521	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
59374005522	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
59374005523	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
59374005524	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
59374005525	ATP cone domain; Region: ATP-cone; pfam03477
59374005526	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
59374005527	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
59374005528	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
59374005529	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374005530	FeS/SAM binding site; other site
59374005531	Protein of unknown function (DUF511); Region: DUF511; pfam04373
59374005532	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374005533	active site
59374005534	catalytic triad [active]
59374005535	oxyanion hole [active]
59374005536	TIGR02147 family protein; Region: Fsuc_second
59374005537	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
59374005538	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
59374005539	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
59374005540	AAA domain; Region: AAA_30; pfam13604
59374005541	Family description; Region: UvrD_C_2; pfam13538
59374005542	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
59374005543	Carbon starvation protein CstA; Region: CstA; pfam02554
59374005544	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
59374005545	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
59374005546	Quinolinate synthetase A protein; Region: NadA; pfam02445
59374005547	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
59374005548	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
59374005549	active site
59374005550	metal binding site [ion binding]; metal-binding site
59374005551	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
59374005552	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59374005553	RNA binding surface [nucleotide binding]; other site
59374005554	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
59374005555	active site
59374005556	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
59374005557	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
59374005558	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
59374005559	active site
59374005560	oligomerization interface [polypeptide binding]; other site
59374005561	metal binding site [ion binding]; metal-binding site
59374005562	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
59374005563	Recombination protein O N terminal; Region: RecO_N; pfam11967
59374005564	Recombination protein O C terminal; Region: RecO_C; pfam02565
59374005565	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
59374005566	nucleotide binding site/active site [active]
59374005567	HIT family signature motif; other site
59374005568	catalytic residue [active]
59374005569	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
59374005570	putative acyl-acceptor binding pocket; other site
59374005571	Cache domain; Region: Cache_1; pfam02743
59374005572	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
59374005573	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
59374005574	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
59374005575	AAA domain; Region: AAA_11; pfam13086
59374005576	AAA domain; Region: AAA_30; pfam13604
59374005577	AAA domain; Region: AAA_11; pfam13086
59374005578	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
59374005579	AAA domain; Region: AAA_12; pfam13087
59374005580	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
59374005581	active site
59374005582	ATP binding site [chemical binding]; other site
59374005583	substrate binding site [chemical binding]; other site
59374005584	activation loop (A-loop); other site
59374005585	Protein phosphatase 2C; Region: PP2C_2; pfam13672
59374005586	active site
59374005587	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
59374005588	metal ion-dependent adhesion site (MIDAS); other site
59374005589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374005590	Walker A motif; other site
59374005591	ATP binding site [chemical binding]; other site
59374005592	Walker B motif; other site
59374005593	arginine finger; other site
59374005594	Flavin Reductases; Region: FlaRed; cl00801
59374005595	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
59374005596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59374005597	motif II; other site
59374005598	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
59374005599	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
59374005600	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005601	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
59374005602	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
59374005603	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
59374005604	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
59374005605	RNA binding site [nucleotide binding]; other site
59374005606	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
59374005607	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
59374005608	nucleotide binding site [chemical binding]; other site
59374005609	N-acetyl-L-glutamate binding site [chemical binding]; other site
59374005610	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
59374005611	acetylornithine aminotransferase; Provisional; Region: PRK02627
59374005612	inhibitor-cofactor binding pocket; inhibition site
59374005613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374005614	catalytic residue [active]
59374005615	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005616	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005617	metal binding site [ion binding]; metal-binding site
59374005618	active site
59374005619	I-site; other site
59374005620	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
59374005621	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
59374005622	active site
59374005623	DNA binding site [nucleotide binding]
59374005624	Int/Topo IB signature motif; other site
59374005625	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
59374005626	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
59374005627	B12 binding domain; Region: B12-binding; pfam02310
59374005628	B12 binding site [chemical binding]; other site
59374005629	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374005630	FeS/SAM binding site; other site
59374005631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
59374005632	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
59374005633	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
59374005634	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
59374005635	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
59374005636	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
59374005637	Walker A/P-loop; other site
59374005638	ATP binding site [chemical binding]; other site
59374005639	Q-loop/lid; other site
59374005640	ABC transporter signature motif; other site
59374005641	Walker B; other site
59374005642	D-loop; other site
59374005643	H-loop/switch region; other site
59374005644	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
59374005645	Protein of unknown function (DUF330); Region: DUF330; cl01135
59374005646	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
59374005647	mce related protein; Region: MCE; pfam02470
59374005648	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
59374005649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374005650	Walker A/P-loop; other site
59374005651	ATP binding site [chemical binding]; other site
59374005652	Q-loop/lid; other site
59374005653	ABC transporter signature motif; other site
59374005654	Walker B; other site
59374005655	D-loop; other site
59374005656	H-loop/switch region; other site
59374005657	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
59374005658	Permease; Region: Permease; pfam02405
59374005659	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
59374005660	TRAM domain; Region: TRAM; pfam01938
59374005661	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
59374005662	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374005663	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374005664	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
59374005665	putative FMN binding site [chemical binding]; other site
59374005666	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
59374005667	dimer interface [polypeptide binding]; other site
59374005668	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
59374005669	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
59374005670	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
59374005671	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
59374005672	putative active site [active]
59374005673	substrate binding site [chemical binding]; other site
59374005674	putative cosubstrate binding site; other site
59374005675	catalytic site [active]
59374005676	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
59374005677	substrate binding site [chemical binding]; other site
59374005678	16S rRNA methyltransferase B; Provisional; Region: PRK14902
59374005679	NusB family; Region: NusB; pfam01029
59374005680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374005681	S-adenosylmethionine binding site [chemical binding]; other site
59374005682	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
59374005683	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
59374005684	minor groove reading motif; other site
59374005685	helix-hairpin-helix signature motif; other site
59374005686	substrate binding pocket [chemical binding]; other site
59374005687	active site
59374005688	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
59374005689	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
59374005690	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374005691	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
59374005692	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
59374005693	active site
59374005694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374005695	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
59374005696	NAD(P) binding site [chemical binding]; other site
59374005697	active site
59374005698	shikimate kinase; Reviewed; Region: aroK; PRK00131
59374005699	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
59374005700	ADP binding site [chemical binding]; other site
59374005701	magnesium binding site [ion binding]; other site
59374005702	putative shikimate binding site; other site
59374005703	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
59374005704	active site
59374005705	dimer interface [polypeptide binding]; other site
59374005706	metal binding site [ion binding]; metal-binding site
59374005707	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
59374005708	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
59374005709	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
59374005710	shikimate binding site; other site
59374005711	NAD(P) binding site [chemical binding]; other site
59374005712	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
59374005713	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
59374005714	G1 box; other site
59374005715	GTP/Mg2+ binding site [chemical binding]; other site
59374005716	Switch I region; other site
59374005717	G2 box; other site
59374005718	Switch II region; other site
59374005719	G3 box; other site
59374005720	G4 box; other site
59374005721	G5 box; other site
59374005722	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
59374005723	G1 box; other site
59374005724	GTP/Mg2+ binding site [chemical binding]; other site
59374005725	Switch I region; other site
59374005726	G2 box; other site
59374005727	G3 box; other site
59374005728	Switch II region; other site
59374005729	G4 box; other site
59374005730	G5 box; other site
59374005731	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
59374005732	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
59374005733	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
59374005734	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
59374005735	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374005736	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
59374005737	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
59374005738	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
59374005739	Bacterial sugar transferase; Region: Bac_transf; pfam02397
59374005740	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374005741	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374005742	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374005743	catalytic triad [active]
59374005744	homoserine dehydrogenase; Provisional; Region: PRK06349
59374005745	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
59374005746	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
59374005747	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
59374005748	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
59374005749	Bacterial sugar transferase; Region: Bac_transf; pfam02397
59374005750	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
59374005751	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
59374005752	dimerization interface [polypeptide binding]; other site
59374005753	active site
59374005754	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59374005755	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
59374005756	NAD binding site [chemical binding]; other site
59374005757	putative substrate binding site 2 [chemical binding]; other site
59374005758	putative substrate binding site 1 [chemical binding]; other site
59374005759	active site
59374005760	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
59374005761	Helix-turn-helix domain; Region: HTH_18; pfam12833
59374005762	Repair protein; Region: Repair_PSII; pfam04536
59374005763	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
59374005764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
59374005765	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
59374005766	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
59374005767	putative active site [active]
59374005768	catalytic triad [active]
59374005769	putative dimer interface [polypeptide binding]; other site
59374005770	Predicted methyltransferases [General function prediction only]; Region: COG0313
59374005771	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
59374005772	putative SAM binding site [chemical binding]; other site
59374005773	putative homodimer interface [polypeptide binding]; other site
59374005774	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
59374005775	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
59374005776	putative active site [active]
59374005777	putative metal binding site [ion binding]; other site
59374005778	TIGR02147 family protein; Region: Fsuc_second
59374005779	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
59374005780	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
59374005781	catalytic residues [active]
59374005782	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
59374005783	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
59374005784	substrate binding site [chemical binding]; other site
59374005785	glutamase interaction surface [polypeptide binding]; other site
59374005786	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
59374005787	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
59374005788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374005789	Walker A motif; other site
59374005790	ATP binding site [chemical binding]; other site
59374005791	Walker B motif; other site
59374005792	arginine finger; other site
59374005793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374005794	Walker A motif; other site
59374005795	ATP binding site [chemical binding]; other site
59374005796	Walker B motif; other site
59374005797	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
59374005798	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
59374005799	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374005800	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374005801	homodimer interface [polypeptide binding]; other site
59374005802	catalytic residue [active]
59374005803	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
59374005804	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
59374005805	active site
59374005806	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
59374005807	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
59374005808	Competence protein; Region: Competence; pfam03772
59374005809	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
59374005810	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
59374005811	Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409
59374005812	active site
59374005813	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
59374005814	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
59374005815	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
59374005816	active site
59374005817	DNA binding site [nucleotide binding]
59374005818	Int/Topo IB signature motif; other site
59374005819	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
59374005820	anti sigma factor interaction site; other site
59374005821	regulatory phosphorylation site [posttranslational modification]; other site
59374005822	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374005823	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
59374005824	dimer interface [polypeptide binding]; other site
59374005825	ADP-ribose binding site [chemical binding]; other site
59374005826	active site
59374005827	nudix motif; other site
59374005828	metal binding site [ion binding]; metal-binding site
59374005829	PA14 domain; Region: PA14; cl08459
59374005830	ribosome maturation protein RimP; Reviewed; Region: PRK00092
59374005831	Sm and related proteins; Region: Sm_like; cl00259
59374005832	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
59374005833	putative oligomer interface [polypeptide binding]; other site
59374005834	putative RNA binding site [nucleotide binding]; other site
59374005835	transcription termination factor NusA; Region: NusA; TIGR01953
59374005836	NusA N-terminal domain; Region: NusA_N; pfam08529
59374005837	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
59374005838	RNA binding site [nucleotide binding]; other site
59374005839	homodimer interface [polypeptide binding]; other site
59374005840	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
59374005841	G-X-X-G motif; other site
59374005842	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
59374005843	G-X-X-G motif; other site
59374005844	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
59374005845	translation initiation factor IF-2; Region: IF-2; TIGR00487
59374005846	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
59374005847	G1 box; other site
59374005848	putative GEF interaction site [polypeptide binding]; other site
59374005849	GTP/Mg2+ binding site [chemical binding]; other site
59374005850	Switch I region; other site
59374005851	G2 box; other site
59374005852	G3 box; other site
59374005853	Switch II region; other site
59374005854	G4 box; other site
59374005855	G5 box; other site
59374005856	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
59374005857	Translation-initiation factor 2; Region: IF-2; pfam11987
59374005858	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
59374005859	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
59374005860	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
59374005861	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
59374005862	RNA binding site [nucleotide binding]; other site
59374005863	active site
59374005864	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
59374005865	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
59374005866	active site
59374005867	Riboflavin kinase; Region: Flavokinase; pfam01687
59374005868	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374005869	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
59374005870	Uncharacterized conserved protein [Function unknown]; Region: COG4279
59374005871	SNF2 Helicase protein; Region: DUF3670; pfam12419
59374005872	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
59374005873	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374005874	ATP binding site [chemical binding]; other site
59374005875	putative Mg++ binding site [ion binding]; other site
59374005876	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374005877	nucleotide binding region [chemical binding]; other site
59374005878	ATP-binding site [chemical binding]; other site
59374005879	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
59374005880	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
59374005881	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374005882	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
59374005883	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
59374005884	UDP-apiose/xylose synthase; Region: PLN02427
59374005885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374005886	NAD(P) binding site [chemical binding]; other site
59374005887	active site
59374005888	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
59374005889	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374005890	Ligand binding site; other site
59374005891	Putative Catalytic site; other site
59374005892	DXD motif; other site
59374005893	MoxR-like ATPases [General function prediction only]; Region: COG0714
59374005894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
59374005895	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
59374005896	Protein of unknown function DUF58; Region: DUF58; pfam01882
59374005897	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
59374005898	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
59374005899	Domain of unknown function (DUF303); Region: DUF303; pfam03629
59374005900	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
59374005901	homodimer interaction site [polypeptide binding]; other site
59374005902	cofactor binding site; other site
59374005903	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
59374005904	Asp-box motif; other site
59374005905	BNR repeat-like domain; Region: BNR_2; pfam13088
59374005906	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374005907	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
59374005908	catalytic core [active]
59374005909	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
59374005910	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
59374005911	NADP binding site [chemical binding]; other site
59374005912	active site
59374005913	putative substrate binding site [chemical binding]; other site
59374005914	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
59374005915	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374005916	FeS/SAM binding site; other site
59374005917	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
59374005918	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
59374005919	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
59374005920	Walker A/P-loop; other site
59374005921	ATP binding site [chemical binding]; other site
59374005922	Q-loop/lid; other site
59374005923	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
59374005924	ABC transporter signature motif; other site
59374005925	Walker B; other site
59374005926	D-loop; other site
59374005927	H-loop/switch region; other site
59374005928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374005929	S-adenosylmethionine binding site [chemical binding]; other site
59374005930	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
59374005931	Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085
59374005932	active site
59374005933	putative catalytic site [active]
59374005934	phosphate binding site A [ion binding]; other site
59374005935	DNA binding site [nucleotide binding]
59374005936	metal binding site A [ion binding]; metal-binding site
59374005937	putative AP binding site [nucleotide binding]; other site
59374005938	putative metal binding site B [ion binding]; other site
59374005939	phosphate binding site B [ion binding]; other site
59374005940	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
59374005941	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
59374005942	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374005943	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
59374005944	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374005945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374005946	homodimer interface [polypeptide binding]; other site
59374005947	catalytic residue [active]
59374005948	GAF domain; Region: GAF; pfam01590
59374005949	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005950	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005951	metal binding site [ion binding]; metal-binding site
59374005952	active site
59374005953	I-site; other site
59374005954	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374005955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374005956	metal binding site [ion binding]; metal-binding site
59374005957	active site
59374005958	I-site; other site
59374005959	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
59374005960	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
59374005961	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
59374005962	generic binding surface II; other site
59374005963	generic binding surface I; other site
59374005964	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
59374005965	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
59374005966	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59374005967	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
59374005968	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59374005969	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
59374005970	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
59374005971	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59374005972	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
59374005973	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
59374005974	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
59374005975	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
59374005976	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
59374005977	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
59374005978	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
59374005979	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
59374005980	NADH dehydrogenase subunit D; Validated; Region: PRK06075
59374005981	NADH dehydrogenase subunit B; Validated; Region: PRK06411
59374005982	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
59374005983	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
59374005984	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
59374005985	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374005986	Zn2+ binding site [ion binding]; other site
59374005987	Mg2+ binding site [ion binding]; other site
59374005988	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
59374005989	synthetase active site [active]
59374005990	NTP binding site [chemical binding]; other site
59374005991	metal binding site [ion binding]; metal-binding site
59374005992	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
59374005993	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
59374005994	phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Region: HSK-PSP; TIGR02137
59374005995	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
59374005996	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
59374005997	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
59374005998	dimerization interface [polypeptide binding]; other site
59374005999	domain crossover interface; other site
59374006000	redox-dependent activation switch; other site
59374006001	DJ-1 family protein; Region: not_thiJ; TIGR01383
59374006002	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
59374006003	conserved cys residue [active]
59374006004	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
59374006005	putative ABC transporter; Region: ycf24; CHL00085
59374006006	DNA topoisomerase III; Provisional; Region: PRK07726
59374006007	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
59374006008	active site
59374006009	putative metal-binding site [ion binding]; other site
59374006010	putative interdomain interaction site [polypeptide binding]; other site
59374006011	putative nucleotide binding site [chemical binding]; other site
59374006012	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
59374006013	domain I; other site
59374006014	DNA binding groove [nucleotide binding]
59374006015	phosphate binding site [ion binding]; other site
59374006016	domain II; other site
59374006017	domain III; other site
59374006018	nucleotide binding site [chemical binding]; other site
59374006019	catalytic site [active]
59374006020	domain IV; other site
59374006021	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
59374006022	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
59374006023	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
59374006024	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
59374006025	2-isopropylmalate synthase; Validated; Region: PRK00915
59374006026	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
59374006027	active site
59374006028	catalytic residues [active]
59374006029	metal binding site [ion binding]; metal-binding site
59374006030	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
59374006031	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374006032	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374006033	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
59374006034	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374006035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374006036	homodimer interface [polypeptide binding]; other site
59374006037	catalytic residue [active]
59374006038	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374006039	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006040	Pectate lyase; Region: Pec_lyase_C; cl01593
59374006041	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006042	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374006043	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374006044	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374006045	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006046	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
59374006047	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
59374006048	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
59374006049	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59374006050	Preprotein translocase SecG subunit; Region: SecG; cl09123
59374006051	triosephosphate isomerase; Provisional; Region: PRK14567
59374006052	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
59374006053	substrate binding site [chemical binding]; other site
59374006054	dimer interface [polypeptide binding]; other site
59374006055	catalytic triad [active]
59374006056	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374006057	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006058	recombinase A; Provisional; Region: recA; PRK09354
59374006059	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
59374006060	hexamer interface [polypeptide binding]; other site
59374006061	Walker A motif; other site
59374006062	ATP binding site [chemical binding]; other site
59374006063	Walker B motif; other site
59374006064	Competence-damaged protein; Region: CinA; pfam02464
59374006065	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
59374006066	catalytic core [active]
59374006067	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006068	Ca2+ binding site [ion binding]; other site
59374006069	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006070	Ca2+ binding site [ion binding]; other site
59374006071	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006072	Ca2+ binding site [ion binding]; other site
59374006073	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006074	Ca2+ binding site [ion binding]; other site
59374006075	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006076	Ca2+ binding site [ion binding]; other site
59374006077	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006078	Ca2+ binding site [ion binding]; other site
59374006079	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006080	Ca2+ binding site [ion binding]; other site
59374006081	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006082	Ca2+ binding site [ion binding]; other site
59374006083	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006084	Ca2+ binding site [ion binding]; other site
59374006085	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006086	Ca2+ binding site [ion binding]; other site
59374006087	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006088	Ca2+ binding site [ion binding]; other site
59374006089	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
59374006090	Ca2+ binding site [ion binding]; other site
59374006091	translation initiation factor Sui1; Validated; Region: PRK06824
59374006092	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
59374006093	putative rRNA binding site [nucleotide binding]; other site
59374006094	endonuclease IV; Provisional; Region: PRK01060
59374006095	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
59374006096	AP (apurinic/apyrimidinic) site pocket; other site
59374006097	DNA interaction; other site
59374006098	Metal-binding active site; metal-binding site
59374006099	hypothetical protein; Provisional; Region: PRK13665
59374006100	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
59374006101	active site residues [active]
59374006102	dimer interface [polypeptide binding]; other site
59374006103	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
59374006104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374006105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374006106	dimer interface [polypeptide binding]; other site
59374006107	phosphorylation site [posttranslational modification]
59374006108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374006109	ATP binding site [chemical binding]; other site
59374006110	Mg2+ binding site [ion binding]; other site
59374006111	G-X-G motif; other site
59374006112	Response regulator receiver domain; Region: Response_reg; pfam00072
59374006113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374006114	active site
59374006115	phosphorylation site [posttranslational modification]
59374006116	intermolecular recognition site; other site
59374006117	dimerization interface [polypeptide binding]; other site
59374006118	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374006119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374006120	active site
59374006121	phosphorylation site [posttranslational modification]
59374006122	intermolecular recognition site; other site
59374006123	dimerization interface [polypeptide binding]; other site
59374006124	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
59374006125	16S/18S rRNA binding site [nucleotide binding]; other site
59374006126	S13e-L30e interaction site [polypeptide binding]; other site
59374006127	25S rRNA binding site [nucleotide binding]; other site
59374006128	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
59374006129	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
59374006130	RNase E interface [polypeptide binding]; other site
59374006131	trimer interface [polypeptide binding]; other site
59374006132	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
59374006133	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
59374006134	RNase E interface [polypeptide binding]; other site
59374006135	trimer interface [polypeptide binding]; other site
59374006136	active site
59374006137	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
59374006138	putative nucleic acid binding region [nucleotide binding]; other site
59374006139	G-X-X-G motif; other site
59374006140	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
59374006141	RNA binding site [nucleotide binding]; other site
59374006142	domain interface; other site
59374006143	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374006144	Zn2+ binding site [ion binding]; other site
59374006145	Mg2+ binding site [ion binding]; other site
59374006146	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374006147	Zn2+ binding site [ion binding]; other site
59374006148	Mg2+ binding site [ion binding]; other site
59374006149	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
59374006150	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
59374006151	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
59374006152	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
59374006153	putative ligand binding site [chemical binding]; other site
59374006154	putative NAD binding site [chemical binding]; other site
59374006155	putative catalytic site [active]
59374006156	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
59374006157	L-serine binding site [chemical binding]; other site
59374006158	ACT domain interface; other site
59374006159	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
59374006160	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
59374006161	acyl-activating enzyme (AAE) consensus motif; other site
59374006162	putative AMP binding site [chemical binding]; other site
59374006163	putative active site [active]
59374006164	putative CoA binding site [chemical binding]; other site
59374006165	seryl-tRNA synthetase; Provisional; Region: PRK05431
59374006166	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
59374006167	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
59374006168	dimer interface [polypeptide binding]; other site
59374006169	active site
59374006170	motif 1; other site
59374006171	motif 2; other site
59374006172	motif 3; other site
59374006173	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
59374006174	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
59374006175	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
59374006176	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
59374006177	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
59374006178	Stage II sporulation protein; Region: SpoIID; pfam08486
59374006179	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
59374006180	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
59374006181	active site
59374006182	catalytic residues [active]
59374006183	metal binding site [ion binding]; metal-binding site
59374006184	Preprotein translocase subunit; Region: YajC; pfam02699
59374006185	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59374006186	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
59374006187	ligand binding site [chemical binding]; other site
59374006188	flexible hinge region; other site
59374006189	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59374006190	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
59374006191	ligand binding site [chemical binding]; other site
59374006192	flexible hinge region; other site
59374006193	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
59374006194	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
59374006195	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
59374006196	RimM N-terminal domain; Region: RimM; pfam01782
59374006197	PRC-barrel domain; Region: PRC; pfam05239
59374006198	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
59374006199	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374006200	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374006201	metal binding site [ion binding]; metal-binding site
59374006202	active site
59374006203	I-site; other site
59374006204	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
59374006205	signal recognition particle protein; Provisional; Region: PRK10867
59374006206	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
59374006207	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
59374006208	P loop; other site
59374006209	GTP binding site [chemical binding]; other site
59374006210	Signal peptide binding domain; Region: SRP_SPB; pfam02978
59374006211	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374006212	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
59374006213	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
59374006214	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
59374006215	hypothetical protein; Provisional; Region: PRK08912
59374006216	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374006217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374006218	homodimer interface [polypeptide binding]; other site
59374006219	catalytic residue [active]
59374006220	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
59374006221	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
59374006222	Dynein light chain type 1; Region: Dynein_light; cl03131
59374006223	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
59374006224	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
59374006225	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
59374006226	active site
59374006227	catalytic residues [active]
59374006228	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
59374006229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006230	Walker A motif; other site
59374006231	ATP binding site [chemical binding]; other site
59374006232	Walker B motif; other site
59374006233	arginine finger; other site
59374006234	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
59374006235	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
59374006236	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
59374006237	transcription termination factor Rho; Provisional; Region: rho; PRK09376
59374006238	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
59374006239	RNA binding site [nucleotide binding]; other site
59374006240	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374006241	Walker A motif; other site
59374006242	ATP binding site [chemical binding]; other site
59374006243	Walker B motif; other site
59374006244	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
59374006245	catalytic center binding site [active]
59374006246	ATP binding site [chemical binding]; other site
59374006247	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
59374006248	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
59374006249	Substrate-binding site [chemical binding]; other site
59374006250	Substrate specificity [chemical binding]; other site
59374006251	Pantoate-beta-alanine ligase; Region: PanC; cd00560
59374006252	pantoate--beta-alanine ligase; Region: panC; TIGR00018
59374006253	active site
59374006254	ATP-binding site [chemical binding]; other site
59374006255	pantoate-binding site; other site
59374006256	HXXH motif; other site
59374006257	CHASE2 domain; Region: CHASE2; pfam05226
59374006258	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
59374006259	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
59374006260	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
59374006261	cyclase homology domain; Region: CHD; cd07302
59374006262	nucleotidyl binding site; other site
59374006263	metal binding site [ion binding]; metal-binding site
59374006264	dimer interface [polypeptide binding]; other site
59374006265	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
59374006266	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
59374006267	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
59374006268	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
59374006269	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374006270	AMP-binding enzyme; Region: AMP-binding; pfam00501
59374006271	acyl-activating enzyme (AAE) consensus motif; other site
59374006272	AMP binding site [chemical binding]; other site
59374006273	active site
59374006274	CoA binding site [chemical binding]; other site
59374006275	Condensation domain; Region: Condensation; pfam00668
59374006276	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
59374006277	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
59374006278	anti sigma factor interaction site; other site
59374006279	regulatory phosphorylation site [posttranslational modification]; other site
59374006280	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
59374006281	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
59374006282	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
59374006283	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
59374006284	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
59374006285	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
59374006286	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
59374006287	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
59374006288	5S rRNA interface [nucleotide binding]; other site
59374006289	CTC domain interface [polypeptide binding]; other site
59374006290	L16 interface [polypeptide binding]; other site
59374006291	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
59374006292	putative active site [active]
59374006293	catalytic residue [active]
59374006294	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
59374006295	Domain of unknown function (DUF4417); Region: DUF4417; pfam14386
59374006296	Domain of unknown function (DUF955); Region: DUF955; pfam06114
59374006297	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374006298	non-specific DNA binding site [nucleotide binding]; other site
59374006299	salt bridge; other site
59374006300	sequence-specific DNA binding site [nucleotide binding]; other site
59374006301	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
59374006302	Methyltransferase domain; Region: Methyltransf_26; pfam13659
59374006303	DEAD-like helicases superfamily; Region: DEXDc; smart00487
59374006304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374006305	ATP binding site [chemical binding]; other site
59374006306	putative Mg++ binding site [ion binding]; other site
59374006307	T5orf172 domain; Region: T5orf172; pfam10544
59374006308	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374006309	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
59374006310	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
59374006311	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
59374006312	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
59374006313	active site
59374006314	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
59374006315	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
59374006316	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
59374006317	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
59374006318	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
59374006319	Cation efflux family; Region: Cation_efflux; pfam01545
59374006320	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
59374006321	ligand binding site [chemical binding]; other site
59374006322	active site
59374006323	UGI interface [polypeptide binding]; other site
59374006324	catalytic site [active]
59374006325	Methyltransferase domain; Region: Methyltransf_26; pfam13659
59374006326	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
59374006327	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
59374006328	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
59374006329	Glyco_18 domain; Region: Glyco_18; smart00636
59374006330	active site
59374006331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374006332	Walker A/P-loop; other site
59374006333	ATP binding site [chemical binding]; other site
59374006334	Q-loop/lid; other site
59374006335	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374006336	ABC transporter signature motif; other site
59374006337	Walker B; other site
59374006338	D-loop; other site
59374006339	H-loop/switch region; other site
59374006340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374006341	AAA domain; Region: AAA_21; pfam13304
59374006342	Walker A/P-loop; other site
59374006343	ATP binding site [chemical binding]; other site
59374006344	Q-loop/lid; other site
59374006345	ABC transporter signature motif; other site
59374006346	Walker B; other site
59374006347	D-loop; other site
59374006348	H-loop/switch region; other site
59374006349	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374006350	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
59374006351	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374006352	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374006353	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374006354	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374006355	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374006356	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
59374006357	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
59374006358	metal binding site [ion binding]; metal-binding site
59374006359	active site
59374006360	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374006361	Ca binding site [ion binding]; other site
59374006362	Ca binding site (active) [ion binding]; other site
59374006363	ligand binding site [chemical binding]; other site
59374006364	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006365	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374006366	active site
59374006367	catalytic triad [active]
59374006368	oxyanion hole [active]
59374006369	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374006370	Ca binding site [ion binding]; other site
59374006371	Ca binding site (active) [ion binding]; other site
59374006372	ligand binding site [chemical binding]; other site
59374006373	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
59374006374	active site
59374006375	catalytic triad [active]
59374006376	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374006377	Ca binding site [ion binding]; other site
59374006378	Ca binding site (active) [ion binding]; other site
59374006379	ligand binding site [chemical binding]; other site
59374006380	TIGR02147 family protein; Region: Fsuc_second
59374006381	Amb_all domain; Region: Amb_all; smart00656
59374006382	Right handed beta helix region; Region: Beta_helix; pfam13229
59374006383	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
59374006384	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
59374006385	dimer interface [polypeptide binding]; other site
59374006386	active site
59374006387	glycine-pyridoxal phosphate binding site [chemical binding]; other site
59374006388	folate binding site [chemical binding]; other site
59374006389	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374006390	fibro-slime domain; Region: Fibro_Slime; TIGR02148
59374006391	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
59374006392	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
59374006393	Filamin/ABP280 repeat; Region: Filamin; pfam00630
59374006394	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374006395	putative metal binding site [ion binding]; other site
59374006396	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
59374006397	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
59374006398	Walker A/P-loop; other site
59374006399	ATP binding site [chemical binding]; other site
59374006400	Q-loop/lid; other site
59374006401	ABC transporter signature motif; other site
59374006402	Walker B; other site
59374006403	D-loop; other site
59374006404	H-loop/switch region; other site
59374006405	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
59374006406	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59374006407	Surface antigen; Region: Bac_surface_Ag; pfam01103
59374006408	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
59374006409	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
59374006410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374006411	binding surface
59374006412	TPR motif; other site
59374006413	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59374006414	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
59374006415	active site
59374006416	multimer interface [polypeptide binding]; other site
59374006417	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
59374006418	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
59374006419	putative Iron-sulfur protein interface [polypeptide binding]; other site
59374006420	proximal heme binding site [chemical binding]; other site
59374006421	distal heme binding site [chemical binding]; other site
59374006422	putative dimer interface [polypeptide binding]; other site
59374006423	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
59374006424	L-aspartate oxidase; Provisional; Region: PRK06175
59374006425	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
59374006426	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
59374006427	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
59374006428	Domain of unknown function (DUF4417); Region: DUF4417; pfam14386
59374006429	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
59374006430	Domain of unknown function (DUF955); Region: DUF955; pfam06114
59374006431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374006432	non-specific DNA binding site [nucleotide binding]; other site
59374006433	salt bridge; other site
59374006434	sequence-specific DNA binding site [nucleotide binding]; other site
59374006435	DNA methylase; Region: N6_N4_Mtase; cl17433
59374006436	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
59374006437	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374006438	DNA methylase; Region: N6_N4_Mtase; pfam01555
59374006439	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
59374006440	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
59374006441	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
59374006442	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
59374006443	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
59374006444	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374006445	substrate binding pocket [chemical binding]; other site
59374006446	membrane-bound complex binding site; other site
59374006447	hinge residues; other site
59374006448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374006449	dimer interface [polypeptide binding]; other site
59374006450	conserved gate region; other site
59374006451	putative PBP binding loops; other site
59374006452	ABC-ATPase subunit interface; other site
59374006453	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
59374006454	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
59374006455	Walker A/P-loop; other site
59374006456	ATP binding site [chemical binding]; other site
59374006457	Q-loop/lid; other site
59374006458	ABC transporter signature motif; other site
59374006459	Walker B; other site
59374006460	D-loop; other site
59374006461	H-loop/switch region; other site
59374006462	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374006463	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374006464	hypothetical protein; Reviewed; Region: PRK00024
59374006465	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
59374006466	MPN+ (JAMM) motif; other site
59374006467	Zinc-binding site [ion binding]; other site
59374006468	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374006469	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374006470	ligand binding site [chemical binding]; other site
59374006471	thymidylate synthase; Reviewed; Region: thyA; PRK01827
59374006472	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
59374006473	dimerization interface [polypeptide binding]; other site
59374006474	active site
59374006475	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
59374006476	active site
59374006477	metal binding site [ion binding]; metal-binding site
59374006478	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
59374006479	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
59374006480	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
59374006481	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
59374006482	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
59374006483	ABC-ATPase subunit  interface; other site
59374006484	dimer interface [polypeptide binding]; other site
59374006485	putative PBP binding regions; other site
59374006486	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006487	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006488	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006489	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006490	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006491	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006492	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006493	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006494	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006495	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006496	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006497	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006499	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374006500	Walker A motif; other site
59374006501	ATP binding site [chemical binding]; other site
59374006502	Walker B motif; other site
59374006503	arginine finger; other site
59374006504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006505	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
59374006506	Walker A motif; other site
59374006507	ATP binding site [chemical binding]; other site
59374006508	Walker B motif; other site
59374006509	arginine finger; other site
59374006510	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006511	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374006512	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
59374006513	protein binding site [polypeptide binding]; other site
59374006514	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
59374006515	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
59374006516	Maf-like protein; Region: Maf; pfam02545
59374006517	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
59374006518	active site
59374006519	dimer interface [polypeptide binding]; other site
59374006520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374006521	non-specific DNA binding site [nucleotide binding]; other site
59374006522	salt bridge; other site
59374006523	sequence-specific DNA binding site [nucleotide binding]; other site
59374006524	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
59374006525	putative active site pocket [active]
59374006526	4-fold oligomerization interface [polypeptide binding]; other site
59374006527	metal binding residues [ion binding]; metal-binding site
59374006528	3-fold/trimer interface [polypeptide binding]; other site
59374006529	TIGR02147 family protein; Region: Fsuc_second
59374006530	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374006531	Radical SAM superfamily; Region: Radical_SAM; pfam04055
59374006532	FeS/SAM binding site; other site
59374006533	elongation factor P; Validated; Region: PRK00529
59374006534	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
59374006535	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
59374006536	RNA binding site [nucleotide binding]; other site
59374006537	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
59374006538	RNA binding site [nucleotide binding]; other site
59374006539	Domain of unknown function (DUF303); Region: DUF303; pfam03629
59374006540	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374006541	putative metal binding site [ion binding]; other site
59374006542	thiamine monophosphate kinase; Provisional; Region: PRK05731
59374006543	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
59374006544	ATP binding site [chemical binding]; other site
59374006545	dimerization interface [polypeptide binding]; other site
59374006546	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
59374006547	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
59374006548	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
59374006549	Walker A motif; other site
59374006550	ATP binding site [chemical binding]; other site
59374006551	Walker B motif; other site
59374006552	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
59374006553	Part of AAA domain; Region: AAA_19; pfam13245
59374006554	Family description; Region: UvrD_C_2; pfam13538
59374006555	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
59374006556	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374006557	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
59374006558	active site
59374006559	Helix-hairpin-helix motif; Region: HHH; pfam00633
59374006560	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
59374006561	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
59374006562	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
59374006563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374006564	S-adenosylmethionine binding site [chemical binding]; other site
59374006565	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
59374006566	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59374006567	active site
59374006568	nucleotide binding site [chemical binding]; other site
59374006569	HIGH motif; other site
59374006570	KMSKS motif; other site
59374006571	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
59374006572	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
59374006573	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
59374006574	substrate binding site [chemical binding]; other site
59374006575	ATP binding site [chemical binding]; other site
59374006576	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59374006577	Surface antigen; Region: Bac_surface_Ag; pfam01103
59374006578	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
59374006579	dimer interface [polypeptide binding]; other site
59374006580	substrate binding site [chemical binding]; other site
59374006581	metal binding sites [ion binding]; metal-binding site
59374006582	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
59374006583	UDP-glucose 4-epimerase; Region: PLN02240
59374006584	NAD binding site [chemical binding]; other site
59374006585	homodimer interface [polypeptide binding]; other site
59374006586	active site
59374006587	substrate binding site [chemical binding]; other site
59374006588	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
59374006589	Mechanosensitive ion channel; Region: MS_channel; pfam00924
59374006590	Chorismate mutase type II; Region: CM_2; smart00830
59374006591	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
59374006592	prephenate dehydrogenase; Validated; Region: PRK08507
59374006593	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
59374006594	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
59374006595	putative active site [active]
59374006596	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
59374006597	ATP-NAD kinase; Region: NAD_kinase; pfam01513
59374006598	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
59374006599	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59374006600	RNA binding surface [nucleotide binding]; other site
59374006601	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
59374006602	active site
59374006603	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
59374006604	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59374006605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374006606	homodimer interface [polypeptide binding]; other site
59374006607	catalytic residue [active]
59374006608	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
59374006609	Amb_all domain; Region: Amb_all; smart00656
59374006610	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
59374006611	Ca binding site [ion binding]; other site
59374006612	Ca binding site (active) [ion binding]; other site
59374006613	ligand binding site [chemical binding]; other site
59374006614	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
59374006615	active site
59374006616	metal binding site [ion binding]; metal-binding site
59374006617	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
59374006618	nucleoside/Zn binding site; other site
59374006619	dimer interface [polypeptide binding]; other site
59374006620	catalytic motif [active]
59374006621	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374006622	FeS/SAM binding site; other site
59374006623	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
59374006624	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
59374006625	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
59374006626	FMN binding site [chemical binding]; other site
59374006627	active site
59374006628	catalytic residues [active]
59374006629	substrate binding site [chemical binding]; other site
59374006630	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
59374006631	active site
59374006632	dimerization interface [polypeptide binding]; other site
59374006633	TM2 domain; Region: TM2; cl00984
59374006634	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
59374006635	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374006636	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006637	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374006638	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006639	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374006640	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006641	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
59374006642	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006643	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
59374006644	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006645	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
59374006646	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
59374006647	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
59374006648	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
59374006649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
59374006650	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374006651	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006652	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006653	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006654	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
59374006655	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374006656	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374006657	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374006658	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
59374006659	GIY-YIG motif/motif A; other site
59374006660	putative active site [active]
59374006661	putative metal binding site [ion binding]; other site
59374006662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
59374006663	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
59374006664	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59374006665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59374006666	TPR motif; other site
59374006667	binding surface
59374006668	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
59374006669	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
59374006670	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
59374006671	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374006672	Zn2+ binding site [ion binding]; other site
59374006673	Mg2+ binding site [ion binding]; other site
59374006674	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
59374006675	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
59374006676	L11 interface [polypeptide binding]; other site
59374006677	putative EF-Tu interaction site [polypeptide binding]; other site
59374006678	putative EF-G interaction site [polypeptide binding]; other site
59374006679	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
59374006680	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
59374006681	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
59374006682	Cl- selectivity filter; other site
59374006683	Cl- binding residues [ion binding]; other site
59374006684	pore gating glutamate residue; other site
59374006685	dimer interface [polypeptide binding]; other site
59374006686	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374006687	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374006688	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
59374006689	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374006690	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
59374006691	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374006692	active site
59374006693	oxyanion hole [active]
59374006694	catalytic triad [active]
59374006695	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
59374006696	active site
59374006697	oxyanion hole [active]
59374006698	catalytic triad [active]
59374006699	histidyl-tRNA synthetase; Region: hisS; TIGR00442
59374006700	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
59374006701	dimer interface [polypeptide binding]; other site
59374006702	motif 1; other site
59374006703	active site
59374006704	motif 2; other site
59374006705	motif 3; other site
59374006706	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
59374006707	anticodon binding site; other site
59374006708	malate dehydrogenase; Reviewed; Region: PRK06223
59374006709	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
59374006710	NAD(P) binding site [chemical binding]; other site
59374006711	dimer interface [polypeptide binding]; other site
59374006712	tetramer (dimer of dimers) interface [polypeptide binding]; other site
59374006713	substrate binding site [chemical binding]; other site
59374006714	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006715	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006716	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374006717	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
59374006718	substrate binding site [chemical binding]; other site
59374006719	active site
59374006720	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
59374006721	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
59374006722	substrate binding site [chemical binding]; other site
59374006723	active site
59374006724	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
59374006725	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
59374006726	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
59374006727	substrate binding site [chemical binding]; other site
59374006728	active site
59374006729	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
59374006730	metal binding site [ion binding]; metal-binding site
59374006731	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374006732	ligand binding site [chemical binding]; other site
59374006733	metal binding site [ion binding]; metal-binding site
59374006734	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
59374006735	Interdomain contacts; other site
59374006736	Cytokine receptor motif; other site
59374006737	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
59374006738	Interdomain contacts; other site
59374006739	Cytokine receptor motif; other site
59374006740	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
59374006741	Interdomain contacts; other site
59374006742	Cytokine receptor motif; other site
59374006743	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
59374006744	Interdomain contacts; other site
59374006745	Cytokine receptor motif; other site
59374006746	Protein of unknown function, DUF486; Region: DUF486; cl01236
59374006747	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
59374006748	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
59374006749	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
59374006750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
59374006751	non-specific DNA binding site [nucleotide binding]; other site
59374006752	salt bridge; other site
59374006753	sequence-specific DNA binding site [nucleotide binding]; other site
59374006754	Transglycosylase; Region: Transgly; cl17702
59374006755	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
59374006756	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
59374006757	dimer interface [polypeptide binding]; other site
59374006758	putative anticodon binding site; other site
59374006759	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
59374006760	motif 1; other site
59374006761	active site
59374006762	motif 2; other site
59374006763	motif 3; other site
59374006764	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
59374006765	four helix bundle protein; Region: TIGR02436
59374006766	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
59374006767	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
59374006768	FtsX-like permease family; Region: FtsX; pfam02687
59374006769	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
59374006770	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
59374006771	Walker A/P-loop; other site
59374006772	ATP binding site [chemical binding]; other site
59374006773	Q-loop/lid; other site
59374006774	ABC transporter signature motif; other site
59374006775	Walker B; other site
59374006776	D-loop; other site
59374006777	H-loop/switch region; other site
59374006778	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
59374006779	Clp amino terminal domain; Region: Clp_N; pfam02861
59374006780	Clp amino terminal domain; Region: Clp_N; pfam02861
59374006781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006782	Walker A motif; other site
59374006783	ATP binding site [chemical binding]; other site
59374006784	Walker B motif; other site
59374006785	arginine finger; other site
59374006786	UvrB/uvrC motif; Region: UVR; pfam02151
59374006787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006788	Walker A motif; other site
59374006789	ATP binding site [chemical binding]; other site
59374006790	Walker B motif; other site
59374006791	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
59374006792	adenylate kinase; Region: adk; TIGR01351
59374006793	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
59374006794	AMP-binding site [chemical binding]; other site
59374006795	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
59374006796	TIGR02147 family protein; Region: Fsuc_second
59374006797	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
59374006798	tartrate dehydrogenase; Region: TTC; TIGR02089
59374006799	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
59374006800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006801	Walker A motif; other site
59374006802	ATP binding site [chemical binding]; other site
59374006803	Walker B motif; other site
59374006804	arginine finger; other site
59374006805	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
59374006806	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
59374006807	RuvA N terminal domain; Region: RuvA_N; pfam01330
59374006808	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
59374006809	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59374006810	inhibitor-cofactor binding pocket; inhibition site
59374006811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374006812	catalytic residue [active]
59374006813	Bacterial sugar transferase; Region: Bac_transf; pfam02397
59374006814	D-cysteine desulfhydrase; Validated; Region: PRK03910
59374006815	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
59374006816	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374006817	catalytic residue [active]
59374006818	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
59374006819	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59374006820	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374006821	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
59374006822	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374006823	putative ADP-binding pocket [chemical binding]; other site
59374006824	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
59374006825	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
59374006826	putative ADP-binding pocket [chemical binding]; other site
59374006827	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
59374006828	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374006829	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374006830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
59374006831	active site
59374006832	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
59374006833	4Fe-4S binding domain; Region: Fer4; pfam00037
59374006834	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374006835	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374006836	active site
59374006837	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
59374006838	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175
59374006839	putative ligand binding site [chemical binding]; other site
59374006840	putative NAD binding site [chemical binding]; other site
59374006841	catalytic site [active]
59374006842	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374006843	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
59374006844	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
59374006845	Acyltransferase family; Region: Acyl_transf_3; pfam01757
59374006846	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
59374006847	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
59374006848	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
59374006849	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
59374006850	putative active site [active]
59374006851	putative metal binding site [ion binding]; other site
59374006852	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
59374006853	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
59374006854	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
59374006855	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
59374006856	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
59374006857	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
59374006858	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59374006859	inhibitor-cofactor binding pocket; inhibition site
59374006860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374006861	catalytic residue [active]
59374006862	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
59374006863	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
59374006864	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374006865	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59374006866	active site
59374006867	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
59374006868	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
59374006869	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374006870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
59374006871	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
59374006872	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
59374006873	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
59374006874	active site
59374006875	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59374006876	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59374006877	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
59374006878	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
59374006879	active site
59374006880	homodimer interface [polypeptide binding]; other site
59374006881	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
59374006882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374006883	NAD(P) binding site [chemical binding]; other site
59374006884	active site
59374006885	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
59374006886	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
59374006887	NAD(P) binding site [chemical binding]; other site
59374006888	homodimer interface [polypeptide binding]; other site
59374006889	substrate binding site [chemical binding]; other site
59374006890	active site
59374006891	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
59374006892	putative glycosyl transferase; Provisional; Region: PRK10307
59374006893	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
59374006894	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59374006895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374006896	NAD(P) binding site [chemical binding]; other site
59374006897	active site
59374006898	Bacterial sugar transferase; Region: Bac_transf; pfam02397
59374006899	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
59374006900	putative trimer interface [polypeptide binding]; other site
59374006901	putative CoA binding site [chemical binding]; other site
59374006902	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
59374006903	TIGR02646 family protein; Region: TIGR02646
59374006904	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374006905	AAA domain; Region: AAA_21; pfam13304
59374006906	Walker A/P-loop; other site
59374006907	ATP binding site [chemical binding]; other site
59374006908	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
59374006909	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
59374006910	NAD(P) binding site [chemical binding]; other site
59374006911	homodimer interface [polypeptide binding]; other site
59374006912	substrate binding site [chemical binding]; other site
59374006913	active site
59374006914	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
59374006915	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
59374006916	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
59374006917	putative NAD(P) binding site [chemical binding]; other site
59374006918	active site
59374006919	putative substrate binding site [chemical binding]; other site
59374006920	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
59374006921	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
59374006922	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
59374006923	active site
59374006924	homodimer interface [polypeptide binding]; other site
59374006925	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
59374006926	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
59374006927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374006928	Walker A motif; other site
59374006929	ATP binding site [chemical binding]; other site
59374006930	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
59374006931	Protein of unknown function, DUF608; Region: DUF608; pfam04685
59374006932	Protein of unknown function, DUF608; Region: DUF608; pfam04685
59374006933	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
59374006934	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
59374006935	active site
59374006936	substrate binding site [chemical binding]; other site
59374006937	cosubstrate binding site; other site
59374006938	catalytic site [active]
59374006939	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
59374006940	RNA/DNA hybrid binding site [nucleotide binding]; other site
59374006941	active site
59374006942	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
59374006943	putative active site [active]
59374006944	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
59374006945	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
59374006946	G1 box; other site
59374006947	putative GEF interaction site [polypeptide binding]; other site
59374006948	GTP/Mg2+ binding site [chemical binding]; other site
59374006949	Switch I region; other site
59374006950	G2 box; other site
59374006951	G3 box; other site
59374006952	Switch II region; other site
59374006953	G4 box; other site
59374006954	G5 box; other site
59374006955	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
59374006956	RAMP superfamily; Region: RAMPs; pfam03787
59374006957	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374006958	radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115
59374006959	FeS/SAM binding site; other site
59374006960	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
59374006961	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
59374006962	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
59374006963	putative valine binding site [chemical binding]; other site
59374006964	dimer interface [polypeptide binding]; other site
59374006965	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
59374006966	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
59374006967	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
59374006968	PYR/PP interface [polypeptide binding]; other site
59374006969	dimer interface [polypeptide binding]; other site
59374006970	TPP binding site [chemical binding]; other site
59374006971	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
59374006972	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
59374006973	TPP-binding site [chemical binding]; other site
59374006974	dimer interface [polypeptide binding]; other site
59374006975	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
59374006976	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
59374006977	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
59374006978	Walker A/P-loop; other site
59374006979	ATP binding site [chemical binding]; other site
59374006980	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
59374006981	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
59374006982	ABC transporter signature motif; other site
59374006983	Walker B; other site
59374006984	D-loop; other site
59374006985	H-loop/switch region; other site
59374006986	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
59374006987	EamA-like transporter family; Region: EamA; pfam00892
59374006988	EamA-like transporter family; Region: EamA; pfam00892
59374006989	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
59374006990	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
59374006991	TPP-binding site; other site
59374006992	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
59374006993	PYR/PP interface [polypeptide binding]; other site
59374006994	dimer interface [polypeptide binding]; other site
59374006995	TPP binding site [chemical binding]; other site
59374006996	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
59374006997	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
59374006998	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
59374006999	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
59374007000	active site residue [active]
59374007001	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
59374007002	catalytic motif [active]
59374007003	Zn binding site [ion binding]; other site
59374007004	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
59374007005	RibD C-terminal domain; Region: RibD_C; cl17279
59374007006	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
59374007007	Lumazine binding domain; Region: Lum_binding; pfam00677
59374007008	Lumazine binding domain; Region: Lum_binding; pfam00677
59374007009	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
59374007010	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
59374007011	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
59374007012	dimerization interface [polypeptide binding]; other site
59374007013	active site
59374007014	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
59374007015	homopentamer interface [polypeptide binding]; other site
59374007016	active site
59374007017	transcription antitermination factor NusB; Region: nusB; TIGR01951
59374007018	putative RNA binding site [nucleotide binding]; other site
59374007019	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
59374007020	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
59374007021	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
59374007022	Ligand binding site; other site
59374007023	Putative Catalytic site; other site
59374007024	DXD motif; other site
59374007025	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
59374007026	Ligand binding site; other site
59374007027	Putative Catalytic site; other site
59374007028	DXD motif; other site
59374007029	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
59374007030	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
59374007031	Probable Catalytic site; other site
59374007032	metal-binding site
59374007033	Trm112p-like protein; Region: Trm112p; cl01066
59374007034	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
59374007035	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374007036	ATP binding site [chemical binding]; other site
59374007037	Walker B motif; other site
59374007038	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
59374007039	putative protease; Provisional; Region: PRK15452
59374007040	Peptidase family U32; Region: Peptidase_U32; pfam01136
59374007041	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
59374007042	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
59374007043	DnaA N-terminal domain; Region: DnaA_N; pfam11638
59374007044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
59374007045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374007046	Walker A motif; other site
59374007047	ATP binding site [chemical binding]; other site
59374007048	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
59374007049	DnaA box-binding interface [nucleotide binding]; other site
59374007050	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
59374007051	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
59374007052	putative NAD(P) binding site [chemical binding]; other site
59374007053	active site
59374007054	Predicted amidohydrolase [General function prediction only]; Region: COG0388
59374007055	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
59374007056	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
59374007057	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
59374007058	Ligand Binding Site [chemical binding]; other site
59374007059	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
59374007060	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59374007061	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
59374007062	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
59374007063	active site
59374007064	catalytic residues [active]
59374007065	metal binding site [ion binding]; metal-binding site
59374007066	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
59374007067	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
59374007068	histidinol dehydrogenase; Region: hisD; TIGR00069
59374007069	NAD binding site [chemical binding]; other site
59374007070	dimerization interface [polypeptide binding]; other site
59374007071	product binding site; other site
59374007072	substrate binding site [chemical binding]; other site
59374007073	zinc binding site [ion binding]; other site
59374007074	catalytic residues [active]
59374007075	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
59374007076	Colicin V production protein; Region: Colicin_V; pfam02674
59374007077	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
59374007078	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
59374007079	active site
59374007080	ATP binding site [chemical binding]; other site
59374007081	substrate binding site [chemical binding]; other site
59374007082	activation loop (A-loop); other site
59374007083	L-aspartate oxidase; Provisional; Region: PRK06175
59374007084	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
59374007085	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
59374007086	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
59374007087	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
59374007088	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374007089	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374007090	ligand binding site [chemical binding]; other site
59374007091	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
59374007092	S1 domain; Region: S1_2; pfam13509
59374007093	S1 domain; Region: S1_2; pfam13509
59374007094	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
59374007095	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007096	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007097	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
59374007098	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374007099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59374007100	Walker A/P-loop; other site
59374007101	ATP binding site [chemical binding]; other site
59374007102	Q-loop/lid; other site
59374007103	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374007104	ABC transporter signature motif; other site
59374007105	Walker B; other site
59374007106	D-loop; other site
59374007107	ABC transporter; Region: ABC_tran_2; pfam12848
59374007108	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59374007109	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
59374007110	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
59374007111	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374007112	membrane-bound complex binding site; other site
59374007113	hinge residues; other site
59374007114	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
59374007115	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374007116	substrate binding pocket [chemical binding]; other site
59374007117	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
59374007118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374007119	dimer interface [polypeptide binding]; other site
59374007120	conserved gate region; other site
59374007121	putative PBP binding loops; other site
59374007122	ABC-ATPase subunit interface; other site
59374007123	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
59374007124	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
59374007125	Walker A/P-loop; other site
59374007126	ATP binding site [chemical binding]; other site
59374007127	Q-loop/lid; other site
59374007128	ABC transporter signature motif; other site
59374007129	Walker B; other site
59374007130	D-loop; other site
59374007131	H-loop/switch region; other site
59374007132	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
59374007133	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
59374007134	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
59374007135	dihydropteroate synthase; Region: DHPS; TIGR01496
59374007136	substrate binding pocket [chemical binding]; other site
59374007137	dimer interface [polypeptide binding]; other site
59374007138	inhibitor binding site; inhibition site
59374007139	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
59374007140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59374007141	Walker A motif; other site
59374007142	ATP binding site [chemical binding]; other site
59374007143	Walker B motif; other site
59374007144	arginine finger; other site
59374007145	Peptidase family M41; Region: Peptidase_M41; pfam01434
59374007146	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
59374007147	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
59374007148	Ligand Binding Site [chemical binding]; other site
59374007149	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
59374007150	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
59374007151	S-adenosylmethionine synthetase; Validated; Region: PRK05250
59374007152	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
59374007153	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
59374007154	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
59374007155	Uncharacterized conserved protein [Function unknown]; Region: COG0327
59374007156	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
59374007157	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
59374007158	Peptidase family M23; Region: Peptidase_M23; pfam01551
59374007159	Protein HOTHEAD; Region: PLN02785
59374007160	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
59374007161	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
59374007162	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374007163	Zn2+ binding site [ion binding]; other site
59374007164	Mg2+ binding site [ion binding]; other site
59374007165	PhoH-like protein; Region: PhoH; pfam02562
59374007166	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
59374007167	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
59374007168	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
59374007169	active site
59374007170	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
59374007171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59374007172	putative substrate translocation pore; other site
59374007173	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59374007174	putative acyl-acceptor binding pocket; other site
59374007175	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374007176	acyl-activating enzyme (AAE) consensus motif; other site
59374007177	AMP binding site [chemical binding]; other site
59374007178	active site
59374007179	CoA binding site [chemical binding]; other site
59374007180	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
59374007181	Domain of unknown function (DUF303); Region: DUF303; pfam03629
59374007182	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
59374007183	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
59374007184	active site
59374007185	dimerization interface [polypeptide binding]; other site
59374007186	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
59374007187	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
59374007188	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
59374007189	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
59374007190	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
59374007191	Phosphopantetheine attachment site; Region: PP-binding; cl09936
59374007192	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
59374007193	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
59374007194	dimer interface [polypeptide binding]; other site
59374007195	active site
59374007196	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
59374007197	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
59374007198	active site
59374007199	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
59374007200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374007201	NAD(P) binding site [chemical binding]; other site
59374007202	active site
59374007203	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
59374007204	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59374007205	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
59374007206	putative acyl-acceptor binding pocket; other site
59374007207	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
59374007208	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
59374007209	active site
59374007210	nucleophile elbow; other site
59374007211	glutamate dehydrogenase; Provisional; Region: PRK09414
59374007212	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
59374007213	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
59374007214	NAD(P) binding site [chemical binding]; other site
59374007215	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
59374007216	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374007217	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374007218	metal binding site [ion binding]; metal-binding site
59374007219	active site
59374007220	I-site; other site
59374007221	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
59374007222	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
59374007223	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
59374007224	active site
59374007225	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
59374007226	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
59374007227	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
59374007228	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374007229	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
59374007230	Uncharacterized conserved protein [Function unknown]; Region: COG4198
59374007231	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
59374007232	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
59374007233	GTP-binding protein LepA; Provisional; Region: PRK05433
59374007234	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
59374007235	G1 box; other site
59374007236	putative GEF interaction site [polypeptide binding]; other site
59374007237	GTP/Mg2+ binding site [chemical binding]; other site
59374007238	Switch I region; other site
59374007239	G2 box; other site
59374007240	G3 box; other site
59374007241	Switch II region; other site
59374007242	G4 box; other site
59374007243	G5 box; other site
59374007244	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
59374007245	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
59374007246	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
59374007247	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
59374007248	active site
59374007249	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
59374007250	LexA repressor; Validated; Region: PRK00215
59374007251	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
59374007252	Catalytic site [active]
59374007253	Fn3 associated; Region: Fn3_assoc; pfam13287
59374007254	CotH protein; Region: CotH; pfam08757
59374007255	Methyltransferase domain; Region: Methyltransf_23; pfam13489
59374007256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374007257	S-adenosylmethionine binding site [chemical binding]; other site
59374007258	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
59374007259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
59374007260	Uncharacterized conserved protein [Function unknown]; Region: COG2308
59374007261	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
59374007262	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
59374007263	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
59374007264	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
59374007265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
59374007266	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
59374007267	acetolactate synthase; Reviewed; Region: PRK08322
59374007268	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
59374007269	PYR/PP interface [polypeptide binding]; other site
59374007270	dimer interface [polypeptide binding]; other site
59374007271	TPP binding site [chemical binding]; other site
59374007272	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
59374007273	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
59374007274	TPP-binding site [chemical binding]; other site
59374007275	dimer interface [polypeptide binding]; other site
59374007276	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
59374007277	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
59374007278	dimer interface [polypeptide binding]; other site
59374007279	anticodon binding site; other site
59374007280	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
59374007281	homodimer interface [polypeptide binding]; other site
59374007282	motif 1; other site
59374007283	active site
59374007284	motif 2; other site
59374007285	GAD domain; Region: GAD; pfam02938
59374007286	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59374007287	active site
59374007288	motif 3; other site
59374007289	V-type ATP synthase subunit E; Provisional; Region: PRK01558
59374007290	V-type ATP synthase subunit A; Provisional; Region: PRK04192
59374007291	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
59374007292	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
59374007293	Walker A motif/ATP binding site; other site
59374007294	Walker B motif; other site
59374007295	V-type ATP synthase subunit B; Provisional; Region: PRK02118
59374007296	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
59374007297	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
59374007298	Walker A motif homologous position; other site
59374007299	Walker B motif; other site
59374007300	V-type ATP synthase subunit D; Provisional; Region: PRK02195
59374007301	V-type ATP synthase subunit I; Validated; Region: PRK05771
59374007302	V-type ATP synthase subunit K; Validated; Region: PRK06649
59374007303	V-type ATP synthase subunit K; Validated; Region: PRK06649
59374007304	ATP synthase subunit C; Region: ATP-synt_C; cl00466
59374007305	Phosphotransferase enzyme family; Region: APH; pfam01636
59374007306	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
59374007307	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
59374007308	active site
59374007309	phosphorylation site [posttranslational modification]
59374007310	Methylamine utilisation protein MauE; Region: MauE; pfam07291
59374007311	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
59374007312	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
59374007313	active site
59374007314	HIGH motif; other site
59374007315	KMSKS motif; other site
59374007316	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
59374007317	tRNA binding surface [nucleotide binding]; other site
59374007318	anticodon binding site; other site
59374007319	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
59374007320	putative tRNA-binding site [nucleotide binding]; other site
59374007321	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007322	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007323	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007324	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007325	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
59374007326	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
59374007327	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
59374007328	FMN binding site [chemical binding]; other site
59374007329	dimer interface [polypeptide binding]; other site
59374007330	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
59374007331	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
59374007332	active site
59374007333	metal binding site [ion binding]; metal-binding site
59374007334	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
59374007335	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
59374007336	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
59374007337	tetramer interface [polypeptide binding]; other site
59374007338	active site
59374007339	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
59374007340	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
59374007341	active site
59374007342	ATP binding site [chemical binding]; other site
59374007343	substrate binding site [chemical binding]; other site
59374007344	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
59374007345	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
59374007346	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
59374007347	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374007348	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
59374007349	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
59374007350	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374007351	ATP binding site [chemical binding]; other site
59374007352	putative Mg++ binding site [ion binding]; other site
59374007353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374007354	nucleotide binding region [chemical binding]; other site
59374007355	ATP-binding site [chemical binding]; other site
59374007356	TRCF domain; Region: TRCF; pfam03461
59374007357	TatD related DNase; Region: TatD_DNase; pfam01026
59374007358	active site
59374007359	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374007360	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374007361	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
59374007362	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
59374007363	GatB domain; Region: GatB_Yqey; smart00845
59374007364	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
59374007365	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
59374007366	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
59374007367	DNA-binding site [nucleotide binding]; DNA binding site
59374007368	Transcriptional regulators [Transcription]; Region: PurR; COG1609
59374007369	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
59374007370	Glucose inhibited division protein A; Region: GIDA; pfam01134
59374007371	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
59374007372	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
59374007373	NifU-like domain; Region: NifU; cl00484
59374007374	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
59374007375	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
59374007376	ligand binding site; other site
59374007377	oligomer interface; other site
59374007378	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
59374007379	dimer interface [polypeptide binding]; other site
59374007380	N-terminal domain interface [polypeptide binding]; other site
59374007381	sulfate 1 binding site; other site
59374007382	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
59374007383	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
59374007384	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
59374007385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59374007386	S-adenosylmethionine binding site [chemical binding]; other site
59374007387	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
59374007388	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
59374007389	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
59374007390	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
59374007391	dimer interface [polypeptide binding]; other site
59374007392	PYR/PP interface [polypeptide binding]; other site
59374007393	TPP binding site [chemical binding]; other site
59374007394	substrate binding site [chemical binding]; other site
59374007395	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
59374007396	Domain of unknown function; Region: EKR; pfam10371
59374007397	4Fe-4S binding domain; Region: Fer4_6; pfam12837
59374007398	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
59374007399	TPP-binding site [chemical binding]; other site
59374007400	dimer interface [polypeptide binding]; other site
59374007401	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
59374007402	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
59374007403	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374007404	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
59374007405	active site
59374007406	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
59374007407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374007408	active site
59374007409	phosphorylation site [posttranslational modification]
59374007410	intermolecular recognition site; other site
59374007411	dimerization interface [polypeptide binding]; other site
59374007412	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59374007413	Zn2+ binding site [ion binding]; other site
59374007414	Mg2+ binding site [ion binding]; other site
59374007415	PAS domain; Region: PAS_9; pfam13426
59374007416	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374007417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374007418	dimer interface [polypeptide binding]; other site
59374007419	phosphorylation site [posttranslational modification]
59374007420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374007421	ATP binding site [chemical binding]; other site
59374007422	Mg2+ binding site [ion binding]; other site
59374007423	G-X-G motif; other site
59374007424	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
59374007425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374007426	active site
59374007427	phosphorylation site [posttranslational modification]
59374007428	intermolecular recognition site; other site
59374007429	dimerization interface [polypeptide binding]; other site
59374007430	Response regulator receiver domain; Region: Response_reg; pfam00072
59374007431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374007432	active site
59374007433	phosphorylation site [posttranslational modification]
59374007434	intermolecular recognition site; other site
59374007435	dimerization interface [polypeptide binding]; other site
59374007436	Hpt domain; Region: Hpt; pfam01627
59374007437	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
59374007438	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
59374007439	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
59374007440	intersubunit interface [polypeptide binding]; other site
59374007441	active site
59374007442	zinc binding site [ion binding]; other site
59374007443	Na+ binding site [ion binding]; other site
59374007444	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374007445	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374007446	ligand binding site [chemical binding]; other site
59374007447	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
59374007448	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
59374007449	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
59374007450	active site
59374007451	Zn binding site [ion binding]; other site
59374007452	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59374007453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59374007454	dimer interface [polypeptide binding]; other site
59374007455	phosphorylation site [posttranslational modification]
59374007456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59374007457	ATP binding site [chemical binding]; other site
59374007458	G-X-G motif; other site
59374007459	Response regulator receiver domain; Region: Response_reg; pfam00072
59374007460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59374007461	active site
59374007462	phosphorylation site [posttranslational modification]
59374007463	intermolecular recognition site; other site
59374007464	dimerization interface [polypeptide binding]; other site
59374007465	Predicted transcriptional regulators [Transcription]; Region: COG1695
59374007466	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
59374007467	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
59374007468	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_3; cd11750
59374007469	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
59374007470	PAS fold; Region: PAS; pfam00989
59374007471	prolyl-tRNA synthetase; Provisional; Region: PRK09194
59374007472	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
59374007473	dimer interface [polypeptide binding]; other site
59374007474	motif 1; other site
59374007475	active site
59374007476	motif 2; other site
59374007477	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
59374007478	putative deacylase active site [active]
59374007479	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59374007480	active site
59374007481	motif 3; other site
59374007482	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
59374007483	anticodon binding site; other site
59374007484	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
59374007485	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
59374007486	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
59374007487	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
59374007488	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59374007489	catalytic residues [active]
59374007490	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
59374007491	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
59374007492	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
59374007493	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
59374007494	thiS-thiF/thiG interaction site; other site
59374007495	thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354
59374007496	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
59374007497	ATP binding site [chemical binding]; other site
59374007498	substrate interface [chemical binding]; other site
59374007499	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
59374007500	ThiS interaction site; other site
59374007501	putative active site [active]
59374007502	tetramer interface [polypeptide binding]; other site
59374007503	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
59374007504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374007505	FeS/SAM binding site; other site
59374007506	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
59374007507	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
59374007508	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
59374007509	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
59374007510	thiamine phosphate binding site [chemical binding]; other site
59374007511	active site
59374007512	pyrophosphate binding site [ion binding]; other site
59374007513	Type III pantothenate kinase; Region: Pan_kinase; cl17198
59374007514	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
59374007515	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
59374007516	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374007517	ligand binding site [chemical binding]; other site
59374007518	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
59374007519	Chain length determinant protein; Region: Wzz; pfam02706
59374007520	Chain length determinant protein; Region: Wzz; cl15801
59374007521	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
59374007522	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
59374007523	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
59374007524	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
59374007525	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
59374007526	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59374007527	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
59374007528	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
59374007529	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59374007530	HSP70 interaction site [polypeptide binding]; other site
59374007531	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
59374007532	Zn binding sites [ion binding]; other site
59374007533	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
59374007534	dimer interface [polypeptide binding]; other site
59374007535	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
59374007536	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
59374007537	nucleotide binding site [chemical binding]; other site
59374007538	NEF interaction site [polypeptide binding]; other site
59374007539	SBD interface [polypeptide binding]; other site
59374007540	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
59374007541	addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385
59374007542	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
59374007543	RelB antitoxin; Region: RelB; cl01171
59374007544	PIN domain; Region: PIN_3; pfam13470
59374007545	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
59374007546	substrate binding site [chemical binding]; other site
59374007547	active site
59374007548	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
59374007549	metal binding site [ion binding]; metal-binding site
59374007550	ligand binding site [chemical binding]; other site
59374007551	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
59374007552	putative metal binding site [ion binding]; other site
59374007553	GrpE; Region: GrpE; pfam01025
59374007554	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
59374007555	dimer interface [polypeptide binding]; other site
59374007556	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
59374007557	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
59374007558	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374007559	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
59374007560	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
59374007561	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
59374007562	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374007563	FeS/SAM binding site; other site
59374007564	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
59374007565	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
59374007566	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
59374007567	catalytic site [active]
59374007568	subunit interface [polypeptide binding]; other site
59374007569	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
59374007570	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59374007571	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374007572	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
59374007573	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59374007574	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59374007575	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
59374007576	IMP binding site; other site
59374007577	dimer interface [polypeptide binding]; other site
59374007578	interdomain contacts; other site
59374007579	partial ornithine binding site; other site
59374007580	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
59374007581	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374007582	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59374007583	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
59374007584	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
59374007585	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
59374007586	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
59374007587	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
59374007588	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374007589	ATP binding site [chemical binding]; other site
59374007590	putative Mg++ binding site [ion binding]; other site
59374007591	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
59374007592	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374007593	nucleotide binding region [chemical binding]; other site
59374007594	ATP-binding site [chemical binding]; other site
59374007595	SprT homologues; Region: SprT; cl01182
59374007596	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
59374007597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
59374007598	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
59374007599	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
59374007600	active site
59374007601	substrate-binding site [chemical binding]; other site
59374007602	metal-binding site [ion binding]
59374007603	GTP binding site [chemical binding]; other site
59374007604	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
59374007605	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
59374007606	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
59374007607	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374007608	FeS/SAM binding site; other site
59374007609	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
59374007610	active site
59374007611	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
59374007612	Ligand Binding Site [chemical binding]; other site
59374007613	AAA domain; Region: AAA_26; pfam13500
59374007614	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
59374007615	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
59374007616	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
59374007617	substrate-cofactor binding pocket; other site
59374007618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374007619	catalytic residue [active]
59374007620	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
59374007621	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
59374007622	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
59374007623	metal binding site [ion binding]; metal-binding site
59374007624	active site
59374007625	I-site; other site
59374007626	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
59374007627	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
59374007628	inhibitor-cofactor binding pocket; inhibition site
59374007629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374007630	catalytic residue [active]
59374007631	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
59374007632	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59374007633	Serine hydrolase; Region: Ser_hydrolase; pfam06821
59374007634	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
59374007635	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
59374007636	active site
59374007637	catalytic residues [active]
59374007638	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
59374007639	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
59374007640	dimer interface [polypeptide binding]; other site
59374007641	ssDNA binding site [nucleotide binding]; other site
59374007642	tetramer (dimer of dimers) interface [polypeptide binding]; other site
59374007643	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
59374007644	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
59374007645	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
59374007646	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
59374007647	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
59374007648	alanine racemase; Reviewed; Region: alr; PRK00053
59374007649	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
59374007650	active site
59374007651	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59374007652	dimer interface [polypeptide binding]; other site
59374007653	substrate binding site [chemical binding]; other site
59374007654	catalytic residues [active]
59374007655	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
59374007656	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
59374007657	DNA binding site [nucleotide binding]
59374007658	active site
59374007659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374007660	NAD(P) binding site [chemical binding]; other site
59374007661	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
59374007662	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
59374007663	active site
59374007664	ADP/pyrophosphate binding site [chemical binding]; other site
59374007665	dimerization interface [polypeptide binding]; other site
59374007666	allosteric effector site; other site
59374007667	fructose-1,6-bisphosphate binding site; other site
59374007668	peptide chain release factor 2; Validated; Region: prfB; PRK00578
59374007669	PCRF domain; Region: PCRF; pfam03462
59374007670	RF-1 domain; Region: RF-1; pfam00472
59374007671	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
59374007672	SurA N-terminal domain; Region: SurA_N_3; cl07813
59374007673	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
59374007674	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
59374007675	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
59374007676	putative active site; other site
59374007677	catalytic triad [active]
59374007678	putative dimer interface [polypeptide binding]; other site
59374007679	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
59374007680	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
59374007681	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
59374007682	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
59374007683	active site
59374007684	RNA/DNA hybrid binding site [nucleotide binding]; other site
59374007685	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
59374007686	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
59374007687	active site
59374007688	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
59374007689	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
59374007690	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
59374007691	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
59374007692	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
59374007693	multifunctional aminopeptidase A; Provisional; Region: PRK00913
59374007694	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
59374007695	interface (dimer of trimers) [polypeptide binding]; other site
59374007696	Substrate-binding/catalytic site; other site
59374007697	Zn-binding sites [ion binding]; other site
59374007698	GMP synthase; Reviewed; Region: guaA; PRK00074
59374007699	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
59374007700	AMP/PPi binding site [chemical binding]; other site
59374007701	candidate oxyanion hole; other site
59374007702	catalytic triad [active]
59374007703	potential glutamine specificity residues [chemical binding]; other site
59374007704	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
59374007705	ATP Binding subdomain [chemical binding]; other site
59374007706	Ligand Binding sites [chemical binding]; other site
59374007707	Dimerization subdomain; other site
59374007708	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
59374007709	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
59374007710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59374007711	dimer interface [polypeptide binding]; other site
59374007712	conserved gate region; other site
59374007713	putative PBP binding loops; other site
59374007714	ABC-ATPase subunit interface; other site
59374007715	dihydrodipicolinate reductase; Region: dapB_plant; TIGR02130
59374007716	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
59374007717	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
59374007718	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
59374007719	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
59374007720	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
59374007721	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
59374007722	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
59374007723	N-acetyl-D-glucosamine binding site [chemical binding]; other site
59374007724	catalytic residue [active]
59374007725	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374007726	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374007727	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
59374007728	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374007729	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374007730	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59374007731	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374007732	ligand binding site [chemical binding]; other site
59374007733	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
59374007734	molecular chaperone DnaK; Provisional; Region: PRK13410
59374007735	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
59374007736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374007737	FeS/SAM binding site; other site
59374007738	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59374007739	active site
59374007740	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
59374007741	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
59374007742	dimer interface [polypeptide binding]; other site
59374007743	active site
59374007744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59374007745	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
59374007746	NAD(P) binding site [chemical binding]; other site
59374007747	active site
59374007748	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
59374007749	active site 2 [active]
59374007750	active site 1 [active]
59374007751	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
59374007752	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
59374007753	active site
59374007754	Predicted exporter [General function prediction only]; Region: COG4258
59374007755	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
59374007756	active site
59374007757	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
59374007758	active sites [active]
59374007759	tetramer interface [polypeptide binding]; other site
59374007760	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
59374007761	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
59374007762	putative acyl-acceptor binding pocket; other site
59374007763	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
59374007764	Ligand binding site; other site
59374007765	Putative Catalytic site; other site
59374007766	DXD motif; other site
59374007767	Predicted membrane protein [Function unknown]; Region: COG4648
59374007768	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
59374007769	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374007770	acyl-activating enzyme (AAE) consensus motif; other site
59374007771	AMP binding site [chemical binding]; other site
59374007772	active site
59374007773	CoA binding site [chemical binding]; other site
59374007774	acyl carrier protein; Provisional; Region: PRK05350
59374007775	Phosphopantetheine attachment site; Region: PP-binding; cl09936
59374007776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59374007777	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
59374007778	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
59374007779	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59374007780	putative acyl-acceptor binding pocket; other site
59374007781	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
59374007782	argininosuccinate lyase; Provisional; Region: PRK00855
59374007783	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
59374007784	active sites [active]
59374007785	tetramer interface [polypeptide binding]; other site
59374007786	Fibrobacter succinogenes major paralogous domain; Region: Fib_succ_major; TIGR02145
59374007787	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
59374007788	hypothetical protein; Provisional; Region: PRK09040
59374007789	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
59374007790	ligand binding site [chemical binding]; other site
59374007791	Prominin; Region: Prominin; pfam05478
59374007792	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
59374007793	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
59374007794	nucleoside/Zn binding site; other site
59374007795	dimer interface [polypeptide binding]; other site
59374007796	catalytic motif [active]
59374007797	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
59374007798	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374007799	FeS/SAM binding site; other site
59374007800	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
59374007801	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
59374007802	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
59374007803	dimer interface [polypeptide binding]; other site
59374007804	active site
59374007805	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
59374007806	putative active site [active]
59374007807	putative Zn binding site [ion binding]; other site
59374007808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59374007809	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
59374007810	acyl-activating enzyme (AAE) consensus motif; other site
59374007811	AMP binding site [chemical binding]; other site
59374007812	active site
59374007813	CoA binding site [chemical binding]; other site
59374007814	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
59374007815	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
59374007816	inhibitor-cofactor binding pocket; inhibition site
59374007817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59374007818	catalytic residue [active]
59374007819	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
59374007820	Mechanosensitive ion channel; Region: MS_channel; pfam00924
59374007821	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
59374007822	dimer interface [polypeptide binding]; other site
59374007823	active site
59374007824	Schiff base residues; other site
59374007825	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
59374007826	putative active site [active]
59374007827	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
59374007828	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
59374007829	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
59374007830	active site
59374007831	SAM binding site [chemical binding]; other site
59374007832	homodimer interface [polypeptide binding]; other site
59374007833	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
59374007834	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
59374007835	active site
59374007836	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
59374007837	active site
59374007838	Zn binding site [ion binding]; other site
59374007839	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
59374007840	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
59374007841	domain interfaces; other site
59374007842	active site
59374007843	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
59374007844	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
59374007845	tRNA; other site
59374007846	putative tRNA binding site [nucleotide binding]; other site
59374007847	putative NADP binding site [chemical binding]; other site
59374007848	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
59374007849	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
59374007850	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
59374007851	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59374007852	FeS/SAM binding site; other site
59374007853	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
59374007854	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
59374007855	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
59374007856	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
59374007857	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
59374007858	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
59374007859	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59374007860	catalytic residue [active]
59374007861	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
59374007862	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
59374007863	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
59374007864	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
59374007865	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
59374007866	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
59374007867	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
59374007868	putative catalytic cysteine [active]
59374007869	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
59374007870	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
59374007871	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59374007872	ATP binding site [chemical binding]; other site
59374007873	putative Mg++ binding site [ion binding]; other site
59374007874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59374007875	nucleotide binding region [chemical binding]; other site
59374007876	ATP-binding site [chemical binding]; other site
59374007877	Restriction endonuclease; Region: Mrr_cat; pfam04471
59374007878	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
59374007879	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
59374007880	ligand binding site [chemical binding]; other site
59374007881	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
59374007882	glycyl-tRNA synthetase; Provisional; Region: PRK04173
59374007883	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59374007884	motif 1; other site
59374007885	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
59374007886	active site
59374007887	motif 2; other site
59374007888	motif 3; other site
59374007889	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
59374007890	anticodon binding site; other site
59374007891	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
59374007892	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
59374007893	HflX GTPase family; Region: HflX; cd01878
59374007894	G1 box; other site
59374007895	GTP/Mg2+ binding site [chemical binding]; other site
59374007896	Switch I region; other site
59374007897	G2 box; other site
59374007898	G3 box; other site
59374007899	Switch II region; other site
59374007900	G4 box; other site
59374007901	G5 box; other site
59374007902	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
59374007903	tetramer interfaces [polypeptide binding]; other site
59374007904	binuclear metal-binding site [ion binding]; other site
59374007905	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
59374007906	Na2 binding site [ion binding]; other site
59374007907	putative substrate binding site 1 [chemical binding]; other site
59374007908	Na binding site 1 [ion binding]; other site
59374007909	putative substrate binding site 2 [chemical binding]; other site
59374007910	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
59374007911	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
59374007912	dimer interface [polypeptide binding]; other site
59374007913	active site
59374007914	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
59374007915	catalytic site [active]
59374007916	putative active site [active]
59374007917	putative substrate binding site [chemical binding]; other site
59374007918	dimer interface [polypeptide binding]; other site
59374007919	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
59374007920	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
59374007921	hypothetical protein; Provisional; Region: PRK13690
59374007922	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374007923	membrane-bound complex binding site; other site
59374007924	hinge residues; other site
59374007925	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374007926	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
59374007927	substrate binding pocket [chemical binding]; other site
59374007928	membrane-bound complex binding site; other site
59374007929	hinge residues; other site
59374007930	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
59374007931	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59374007932	substrate binding pocket [chemical binding]; other site
59374007933	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
59374007934	Domain of unknown function (DUF4419); Region: DUF4419; pfam14388
59374007935	Domain of unknown function (DUF4419); Region: DUF4419; pfam14388
59374007936	Domain of unknown function (DUF4419); Region: DUF4419; pfam14388
59374007937	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
59374007938	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
59374007939	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
59374007940	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
59374007941	dimerization interface [polypeptide binding]; other site
59374007942	ATP binding site [chemical binding]; other site
59374007943	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
59374007944	dimerization interface [polypeptide binding]; other site
59374007945	ATP binding site [chemical binding]; other site
59374007946	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
59374007947	putative active site [active]
59374007948	catalytic triad [active]
59374007949	WxcM-like, C-terminal; Region: FdtA; pfam05523
59374007950	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
59374007951	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59374007952	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
59374007953	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
59374007954	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
59374007955	Substrate binding site; other site
59374007956	metal-binding site
59374007957	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
59374007958	putative trimer interface [polypeptide binding]; other site
59374007959	putative CoA binding site [chemical binding]; other site
59374007960	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
59374007961	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
59374007962	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
59374007963	trimer interface [polypeptide binding]; other site
59374007964	active site
59374007965	UDP-GlcNAc binding site [chemical binding]; other site
59374007966	lipid binding site [chemical binding]; lipid-binding site
59374007967	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
59374007968	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
59374007969	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
59374007970	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
59374007971	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
59374007972	trimer interface [polypeptide binding]; other site
59374007973	putative metal binding site [ion binding]; other site
59374007974	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
59374007975	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
59374007976	NAD(P) binding site [chemical binding]; other site
59374007977	catalytic residues [active]
59374007978	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
59374007979	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
59374007980	putative active site [active]
59374007981	metal binding site [ion binding]; metal-binding site
59374007982	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
59374007983	active site
59374007984	glycogen branching enzyme; Provisional; Region: PRK05402
59374007985	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
59374007986	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
59374007987	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
59374007988	active site
59374007989	catalytic site [active]
59374007990	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
59374007991	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
59374007992	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
59374007993	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
59374007994	active site
59374007995	DNA binding site [nucleotide binding]
59374007996	Int/Topo IB signature motif; other site
59374007997	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374007998	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
59374007999	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
59374008000	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
59374008001	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
59374008002	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59374008003	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
59374008004	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
59374008005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59374008006	hypothetical protein; Provisional; Region: PRK11820
59374008007	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
59374008008	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
59374008009	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
59374008010	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
59374008011	active site
59374008012	putative substrate binding pocket [chemical binding]; other site
59374008013	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
59374008014	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
59374008015	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59374008016	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59374008017	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
59374008018	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
59374008019	RNA binding surface [nucleotide binding]; other site
59374008020	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
59374008021	active site
59374008022	lipoprotein signal peptidase; Provisional; Region: PRK14787
59374008023	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
59374008024	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
59374008025	active site lid residues [active]
59374008026	substrate binding pocket [chemical binding]; other site
59374008027	catalytic residues [active]
59374008028	substrate-Mg2+ binding site; other site
59374008029	aspartate-rich region 1; other site
59374008030	aspartate-rich region 2; other site