-- dump date 20140619_093647 -- class Genbank::misc_feature -- table misc_feature_note -- id note 531844000001 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 531844000002 ribonuclease R; Region: RNase_R; TIGR02063 531844000003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 531844000004 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 531844000005 RNB domain; Region: RNB; pfam00773 531844000006 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 531844000007 RNA binding site [nucleotide binding]; other site 531844000008 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 531844000009 dimer interface [polypeptide binding]; other site 531844000010 catalytic triad [active] 531844000011 Predicted membrane protein [Function unknown]; Region: COG4270 531844000012 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 531844000013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844000014 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 531844000015 NAD(P) binding site [chemical binding]; other site 531844000016 active site 531844000017 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 531844000018 Glycoprotease family; Region: Peptidase_M22; pfam00814 531844000019 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 531844000020 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 531844000021 tRNA; other site 531844000022 putative tRNA binding site [nucleotide binding]; other site 531844000023 putative NADP binding site [chemical binding]; other site 531844000024 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 531844000025 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 531844000026 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 531844000027 domain interfaces; other site 531844000028 active site 531844000029 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 531844000030 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 531844000031 active site 531844000032 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 531844000033 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 531844000034 substrate binding site [chemical binding]; other site 531844000035 active site 531844000036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 531844000037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 531844000038 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 531844000039 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 531844000040 HflX GTPase family; Region: HflX; cd01878 531844000041 G1 box; other site 531844000042 GTP/Mg2+ binding site [chemical binding]; other site 531844000043 Switch I region; other site 531844000044 G2 box; other site 531844000045 G3 box; other site 531844000046 Switch II region; other site 531844000047 G4 box; other site 531844000048 G5 box; other site 531844000049 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 531844000050 A new structural DNA glycosylase; Region: AlkD_like; cd06561 531844000051 active site 531844000052 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 531844000053 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 531844000054 heme-binding site [chemical binding]; other site 531844000055 Flagellin N-methylase; Region: FliB; pfam03692 531844000056 glutamate dehydrogenase; Provisional; Region: PRK09414 531844000057 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 531844000058 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 531844000059 NAD(P) binding site [chemical binding]; other site 531844000060 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 531844000061 DNA protecting protein DprA; Region: dprA; TIGR00732 531844000062 Rhomboid family; Region: Rhomboid; cl11446 531844000063 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 531844000064 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 531844000065 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 531844000066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844000067 Walker A motif; other site 531844000068 ATP binding site [chemical binding]; other site 531844000069 Walker B motif; other site 531844000070 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 531844000071 glycyl-tRNA synthetase; Provisional; Region: PRK04173 531844000072 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 531844000073 motif 1; other site 531844000074 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 531844000075 active site 531844000076 motif 2; other site 531844000077 motif 3; other site 531844000078 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 531844000079 anticodon binding site; other site 531844000080 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 531844000081 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 531844000082 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 531844000083 catalytic residue [active] 531844000084 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 531844000085 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 531844000086 catalytic triad [active] 531844000087 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 531844000088 endonuclease III; Region: ENDO3c; smart00478 531844000089 minor groove reading motif; other site 531844000090 helix-hairpin-helix signature motif; other site 531844000091 substrate binding pocket [chemical binding]; other site 531844000092 active site 531844000093 Response regulator receiver domain; Region: Response_reg; pfam00072 531844000094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844000095 active site 531844000096 phosphorylation site [posttranslational modification] 531844000097 intermolecular recognition site; other site 531844000098 dimerization interface [polypeptide binding]; other site 531844000099 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 531844000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844000101 putative active site [active] 531844000102 heme pocket [chemical binding]; other site 531844000103 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 531844000104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844000105 putative active site [active] 531844000106 heme pocket [chemical binding]; other site 531844000107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844000108 putative active site [active] 531844000109 heme pocket [chemical binding]; other site 531844000110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844000111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844000112 dimer interface [polypeptide binding]; other site 531844000113 phosphorylation site [posttranslational modification] 531844000114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844000115 ATP binding site [chemical binding]; other site 531844000116 Mg2+ binding site [ion binding]; other site 531844000117 G-X-G motif; other site 531844000118 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 531844000119 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 531844000120 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 531844000121 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 531844000122 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 531844000123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844000124 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 531844000125 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 531844000126 quinone interaction residues [chemical binding]; other site 531844000127 active site 531844000128 catalytic residues [active] 531844000129 FMN binding site [chemical binding]; other site 531844000130 substrate binding site [chemical binding]; other site 531844000131 Protein of unknown function (DUF445); Region: DUF445; pfam04286 531844000132 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 531844000133 SelR domain; Region: SelR; pfam01641 531844000134 Heavy-metal-associated domain; Region: HMA; pfam00403 531844000135 Heavy-metal-associated domain; Region: HMA; pfam00403 531844000136 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844000137 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844000138 GLPGLI family protein; Region: GLPGLI; TIGR01200 531844000139 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 531844000140 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 531844000141 putative ABC transporter; Region: ycf24; CHL00085 531844000142 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 531844000143 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 531844000144 Walker A/P-loop; other site 531844000145 ATP binding site [chemical binding]; other site 531844000146 Q-loop/lid; other site 531844000147 ABC transporter signature motif; other site 531844000148 Walker B; other site 531844000149 D-loop; other site 531844000150 H-loop/switch region; other site 531844000151 FeS assembly protein SufD; Region: sufD; TIGR01981 531844000152 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 531844000153 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 531844000154 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 531844000155 active site 531844000156 substrate binding site [chemical binding]; other site 531844000157 coenzyme B12 binding site [chemical binding]; other site 531844000158 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 531844000159 B12 binding site [chemical binding]; other site 531844000160 cobalt ligand [ion binding]; other site 531844000161 peptide chain release factor 1; Validated; Region: prfA; PRK00591 531844000162 PCRF domain; Region: PCRF; pfam03462 531844000163 RF-1 domain; Region: RF-1; pfam00472 531844000164 fumarate hydratase; Reviewed; Region: fumC; PRK00485 531844000165 Class II fumarases; Region: Fumarase_classII; cd01362 531844000166 active site 531844000167 tetramer interface [polypeptide binding]; other site 531844000168 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 531844000169 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 531844000170 Walker A/P-loop; other site 531844000171 ATP binding site [chemical binding]; other site 531844000172 Q-loop/lid; other site 531844000173 ABC transporter signature motif; other site 531844000174 Walker B; other site 531844000175 D-loop; other site 531844000176 H-loop/switch region; other site 531844000177 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 531844000178 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 531844000179 Walker A/P-loop; other site 531844000180 ATP binding site [chemical binding]; other site 531844000181 Q-loop/lid; other site 531844000182 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 531844000183 ABC transporter signature motif; other site 531844000184 Walker B; other site 531844000185 D-loop; other site 531844000186 H-loop/switch region; other site 531844000187 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 531844000188 Flavoprotein; Region: Flavoprotein; pfam02441 531844000189 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 531844000190 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 531844000191 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 531844000192 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 531844000193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 531844000194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 531844000195 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 531844000196 active site 531844000197 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 531844000198 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 531844000199 putative ATP binding site [chemical binding]; other site 531844000200 putative substrate interface [chemical binding]; other site 531844000201 Ribonuclease P; Region: Ribonuclease_P; pfam00825 531844000202 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 531844000203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 531844000204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844000205 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 531844000206 Walker A motif; other site 531844000207 ATP binding site [chemical binding]; other site 531844000208 Walker B motif; other site 531844000209 arginine finger; other site 531844000210 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 531844000211 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 531844000212 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 531844000213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844000214 FeS/SAM binding site; other site 531844000215 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 531844000216 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 531844000217 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 531844000218 diaminopimelate decarboxylase; Region: lysA; TIGR01048 531844000219 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 531844000220 active site 531844000221 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 531844000222 substrate binding site [chemical binding]; other site 531844000223 catalytic residues [active] 531844000224 dimer interface [polypeptide binding]; other site 531844000225 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 531844000226 active site 531844000227 catalytic site [active] 531844000228 substrate binding site [chemical binding]; other site 531844000229 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 531844000230 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 531844000231 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 531844000232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 531844000233 active site residue [active] 531844000234 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 531844000235 active site residue [active] 531844000236 Cupin domain; Region: Cupin_2; cl17218 531844000237 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 531844000238 catalytic residues [active] 531844000239 C-N hydrolase family amidase; Provisional; Region: PRK10438 531844000240 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 531844000241 putative active site [active] 531844000242 catalytic triad [active] 531844000243 dimer interface [polypeptide binding]; other site 531844000244 multimer interface [polypeptide binding]; other site 531844000245 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 531844000246 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 531844000247 RIP metalloprotease RseP; Region: TIGR00054 531844000248 active site 531844000249 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 531844000250 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 531844000251 protein binding site [polypeptide binding]; other site 531844000252 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 531844000253 putative substrate binding region [chemical binding]; other site 531844000254 peptidase T; Region: peptidase-T; TIGR01882 531844000255 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 531844000256 metal binding site [ion binding]; metal-binding site 531844000257 dimer interface [polypeptide binding]; other site 531844000258 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 531844000259 active site 531844000260 catalytic residues [active] 531844000261 metal binding site [ion binding]; metal-binding site 531844000262 rod shape-determining protein MreB; Provisional; Region: PRK13927 531844000263 MreB and similar proteins; Region: MreB_like; cd10225 531844000264 nucleotide binding site [chemical binding]; other site 531844000265 Mg binding site [ion binding]; other site 531844000266 putative protofilament interaction site [polypeptide binding]; other site 531844000267 RodZ interaction site [polypeptide binding]; other site 531844000268 rod shape-determining protein MreC; Provisional; Region: PRK13922 531844000269 rod shape-determining protein MreC; Region: MreC; pfam04085 531844000270 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 531844000271 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 531844000272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 531844000273 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 531844000274 NlpC/P60 family; Region: NLPC_P60; pfam00877 531844000275 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 531844000276 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 531844000277 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 531844000278 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 531844000279 Zn binding site [ion binding]; other site 531844000280 Type III pantothenate kinase; Region: Pan_kinase; cl17198 531844000281 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 531844000282 nucleoside/Zn binding site; other site 531844000283 dimer interface [polypeptide binding]; other site 531844000284 catalytic motif [active] 531844000285 Gram-negative bacterial tonB protein; Region: TonB; cl10048 531844000286 Domain of unknown function DUF59; Region: DUF59; cl00941 531844000287 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 531844000288 active site 531844000289 catalytic site [active] 531844000290 substrate binding site [chemical binding]; other site 531844000291 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 531844000292 dimer interface [polypeptide binding]; other site 531844000293 putative tRNA-binding site [nucleotide binding]; other site 531844000294 cytochrome c-550; Provisional; Region: psbV; cl17239 531844000295 Cytochrome c; Region: Cytochrom_C; cl11414 531844000296 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 531844000297 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 531844000298 metal binding site [ion binding]; metal-binding site 531844000299 substrate binding pocket [chemical binding]; other site 531844000300 ArgK protein; Region: ArgK; pfam03308 531844000301 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 531844000302 Walker A; other site 531844000303 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 531844000304 Peptidase family M48; Region: Peptidase_M48; pfam01435 531844000305 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844000306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 531844000307 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 531844000308 Walker A/P-loop; other site 531844000309 ATP binding site [chemical binding]; other site 531844000310 Q-loop/lid; other site 531844000311 ABC transporter signature motif; other site 531844000312 Walker B; other site 531844000313 D-loop; other site 531844000314 H-loop/switch region; other site 531844000315 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 531844000316 Permease; Region: Permease; pfam02405 531844000317 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 531844000318 Bacterial sugar transferase; Region: Bac_transf; pfam02397 531844000319 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 531844000320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844000321 FeS/SAM binding site; other site 531844000322 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 531844000323 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 531844000324 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 531844000325 homodimer interface [polypeptide binding]; other site 531844000326 NADP binding site [chemical binding]; other site 531844000327 substrate binding site [chemical binding]; other site 531844000328 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 531844000329 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 531844000330 active site 531844000331 dimer interface [polypeptide binding]; other site 531844000332 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 531844000333 dimer interface [polypeptide binding]; other site 531844000334 active site 531844000335 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 531844000336 Found in ATP-dependent protease La (LON); Region: LON; smart00464 531844000337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844000338 Walker A motif; other site 531844000339 ATP binding site [chemical binding]; other site 531844000340 Walker B motif; other site 531844000341 arginine finger; other site 531844000342 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 531844000343 SurA N-terminal domain; Region: SurA_N_3; cl07813 531844000344 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 531844000345 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 531844000346 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 531844000347 mce related protein; Region: MCE; pfam02470 531844000348 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 531844000349 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 531844000350 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 531844000351 Cysteine-rich domain; Region: CCG; pfam02754 531844000352 Cysteine-rich domain; Region: CCG; pfam02754 531844000353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000354 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844000355 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 531844000356 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 531844000357 seryl-tRNA synthetase; Provisional; Region: PRK05431 531844000358 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 531844000359 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 531844000360 motif 1; other site 531844000361 dimer interface [polypeptide binding]; other site 531844000362 active site 531844000363 motif 2; other site 531844000364 motif 3; other site 531844000365 Family description; Region: DsbD_2; pfam13386 531844000366 FixH; Region: FixH; pfam05751 531844000367 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 531844000368 4Fe-4S binding domain; Region: Fer4_5; pfam12801 531844000369 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 531844000370 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 531844000371 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 531844000372 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 531844000373 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 531844000374 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 531844000375 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 531844000376 Low-spin heme binding site [chemical binding]; other site 531844000377 Putative water exit pathway; other site 531844000378 Binuclear center (active site) [active] 531844000379 Putative proton exit pathway; other site 531844000380 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 531844000381 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 531844000382 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 531844000383 Heavy-metal-associated domain; Region: HMA; pfam00403 531844000384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 531844000385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 531844000386 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844000387 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844000388 ligand binding site [chemical binding]; other site 531844000389 flexible hinge region; other site 531844000390 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 531844000391 non-specific DNA interactions [nucleotide binding]; other site 531844000392 DNA binding site [nucleotide binding] 531844000393 sequence specific DNA binding site [nucleotide binding]; other site 531844000394 putative cAMP binding site [chemical binding]; other site 531844000395 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 531844000396 oligomerization interface [polypeptide binding]; other site 531844000397 active site 531844000398 metal binding site [ion binding]; metal-binding site 531844000399 Haem-binding domain; Region: Haem_bd; pfam14376 531844000400 Bacterial Ig-like domain; Region: Big_5; pfam13205 531844000401 Beta-lactamase; Region: Beta-lactamase; pfam00144 531844000402 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 531844000403 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 531844000404 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 531844000405 putative ligand binding site [chemical binding]; other site 531844000406 putative NAD binding site [chemical binding]; other site 531844000407 catalytic site [active] 531844000408 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 531844000409 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844000410 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844000411 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844000412 Interferon-induced transmembrane protein; Region: CD225; pfam04505 531844000413 aconitate hydratase; Validated; Region: PRK07229 531844000414 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 531844000415 substrate binding site [chemical binding]; other site 531844000416 ligand binding site [chemical binding]; other site 531844000417 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 531844000418 substrate binding site [chemical binding]; other site 531844000419 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 531844000420 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 531844000421 active site 531844000422 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 531844000423 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 531844000424 nudix motif; other site 531844000425 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 531844000426 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 531844000427 active site 531844000428 Int/Topo IB signature motif; other site 531844000429 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 531844000430 catalytic motif [active] 531844000431 Zn binding site [ion binding]; other site 531844000432 enoyl-CoA hydratase; Provisional; Region: PRK07658 531844000433 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 531844000434 substrate binding site [chemical binding]; other site 531844000435 oxyanion hole (OAH) forming residues; other site 531844000436 trimer interface [polypeptide binding]; other site 531844000437 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 531844000438 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 531844000439 heme binding pocket [chemical binding]; other site 531844000440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 531844000441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 531844000442 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 531844000443 dimerization interface [polypeptide binding]; other site 531844000444 S-adenosylmethionine synthetase; Validated; Region: PRK05250 531844000445 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 531844000446 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 531844000447 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 531844000448 RNA polymerase sigma factor; Provisional; Region: PRK12513 531844000449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844000450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 531844000451 DNA binding residues [nucleotide binding] 531844000452 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 531844000453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844000454 motif II; other site 531844000455 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 531844000456 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 531844000457 active site 531844000458 HIGH motif; other site 531844000459 dimer interface [polypeptide binding]; other site 531844000460 KMSKS motif; other site 531844000461 lipoprotein signal peptidase; Provisional; Region: PRK14788 531844000462 lipoprotein signal peptidase; Provisional; Region: PRK14787 531844000463 glutamyl-tRNA reductase; Region: PLN00203 531844000464 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 531844000465 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 531844000466 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844000467 active site 531844000468 HIGH motif; other site 531844000469 nucleotide binding site [chemical binding]; other site 531844000470 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 531844000471 active site 531844000472 KMSKS motif; other site 531844000473 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 531844000474 tRNA binding surface [nucleotide binding]; other site 531844000475 anticodon binding site; other site 531844000476 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 531844000477 Histidine kinase; Region: His_kinase; pfam06580 531844000478 ATP binding site [chemical binding]; other site 531844000479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 531844000480 Mg2+ binding site [ion binding]; other site 531844000481 G-X-G motif; other site 531844000482 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 531844000483 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 531844000484 active site 531844000485 interdomain interaction site; other site 531844000486 putative metal-binding site [ion binding]; other site 531844000487 nucleotide binding site [chemical binding]; other site 531844000488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 531844000489 domain I; other site 531844000490 DNA binding groove [nucleotide binding] 531844000491 phosphate binding site [ion binding]; other site 531844000492 domain II; other site 531844000493 domain III; other site 531844000494 nucleotide binding site [chemical binding]; other site 531844000495 catalytic site [active] 531844000496 domain IV; other site 531844000497 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 531844000498 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 531844000499 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 531844000500 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844000501 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 531844000502 active site 531844000503 metal binding site [ion binding]; metal-binding site 531844000504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844000505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000506 active site 531844000507 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 531844000508 Mg++ binding site [ion binding]; other site 531844000509 putative catalytic motif [active] 531844000510 substrate binding site [chemical binding]; other site 531844000511 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 531844000512 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 531844000513 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 531844000514 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 531844000515 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 531844000516 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 531844000517 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 531844000518 catalytic residue [active] 531844000519 putative FPP diphosphate binding site; other site 531844000520 putative FPP binding hydrophobic cleft; other site 531844000521 dimer interface [polypeptide binding]; other site 531844000522 putative IPP diphosphate binding site; other site 531844000523 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 531844000524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 531844000525 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 531844000526 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 531844000527 Surface antigen; Region: Bac_surface_Ag; pfam01103 531844000528 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 531844000529 periplasmic chaperone; Provisional; Region: PRK10780 531844000530 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 531844000531 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 531844000532 active site 531844000533 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 531844000534 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 531844000535 NADP binding site [chemical binding]; other site 531844000536 active site 531844000537 putative substrate binding site [chemical binding]; other site 531844000538 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 531844000539 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 531844000540 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 531844000541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 531844000542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844000543 Walker A/P-loop; other site 531844000544 ATP binding site [chemical binding]; other site 531844000545 Q-loop/lid; other site 531844000546 ABC transporter signature motif; other site 531844000547 Walker B; other site 531844000548 D-loop; other site 531844000549 H-loop/switch region; other site 531844000550 transcription antitermination factor NusB; Region: nusB; TIGR01951 531844000551 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 531844000552 Preprotein translocase subunit; Region: YajC; pfam02699 531844000553 putative transporter; Validated; Region: PRK03818 531844000554 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 531844000555 TrkA-C domain; Region: TrkA_C; pfam02080 531844000556 TrkA-C domain; Region: TrkA_C; pfam02080 531844000557 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 531844000558 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 531844000559 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 531844000560 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 531844000561 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 531844000562 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 531844000563 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 531844000564 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 531844000565 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 531844000566 dimerization interface [polypeptide binding]; other site 531844000567 active site 531844000568 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 531844000569 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 531844000570 Peptidase family M23; Region: Peptidase_M23; pfam01551 531844000571 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 531844000572 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 531844000573 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 531844000574 active site 531844000575 Substrate binding site; other site 531844000576 Mg++ binding site; other site 531844000577 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 531844000578 putative trimer interface [polypeptide binding]; other site 531844000579 putative CoA binding site [chemical binding]; other site 531844000580 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 531844000581 trimer interface [polypeptide binding]; other site 531844000582 active site 531844000583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 531844000584 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 531844000585 dihydroorotase; Reviewed; Region: PRK09236 531844000586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 531844000587 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 531844000588 active site 531844000589 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 531844000590 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 531844000591 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 531844000592 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 531844000593 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 531844000594 Double zinc ribbon; Region: DZR; pfam12773 531844000595 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 531844000596 short chain dehydrogenase; Provisional; Region: PRK07677 531844000597 NAD(P) binding site [chemical binding]; other site 531844000598 substrate binding site [chemical binding]; other site 531844000599 homotetramer interface [polypeptide binding]; other site 531844000600 active site 531844000601 homodimer interface [polypeptide binding]; other site 531844000602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844000603 non-specific DNA binding site [nucleotide binding]; other site 531844000604 salt bridge; other site 531844000605 sequence-specific DNA binding site [nucleotide binding]; other site 531844000606 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 531844000607 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 531844000608 hexamer interface [polypeptide binding]; other site 531844000609 Walker A motif; other site 531844000610 ATP binding site [chemical binding]; other site 531844000611 Walker B motif; other site 531844000612 heat shock protein 90; Provisional; Region: PRK05218 531844000613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844000614 ATP binding site [chemical binding]; other site 531844000615 Mg2+ binding site [ion binding]; other site 531844000616 G-X-G motif; other site 531844000617 Deoxyhypusine synthase; Region: DS; cl00826 531844000618 deoxyhypusine synthase; Region: dhys; TIGR00321 531844000619 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 531844000620 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 531844000621 hypothetical protein; Provisional; Region: PRK09256 531844000622 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 531844000623 AMP binding site [chemical binding]; other site 531844000624 active site 531844000625 acyl-activating enzyme (AAE) consensus motif; other site 531844000626 CoA binding site [chemical binding]; other site 531844000627 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 531844000628 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 531844000629 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 531844000630 active site 531844000631 HIGH motif; other site 531844000632 KMSK motif region; other site 531844000633 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 531844000634 tRNA binding surface [nucleotide binding]; other site 531844000635 anticodon binding site; other site 531844000636 starch binding outer membrane protein SusD; Region: SusD; cl17845 531844000637 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844000638 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844000639 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844000640 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 531844000641 RNA/DNA hybrid binding site [nucleotide binding]; other site 531844000642 active site 531844000643 membrane protein insertase; Provisional; Region: PRK01318 531844000644 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 531844000645 CTP synthetase; Validated; Region: pyrG; PRK05380 531844000646 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 531844000647 Catalytic site [active] 531844000648 active site 531844000649 UTP binding site [chemical binding]; other site 531844000650 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 531844000651 active site 531844000652 putative oxyanion hole; other site 531844000653 catalytic triad [active] 531844000654 YceI-like domain; Region: YceI; pfam04264 531844000655 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 531844000656 active site 531844000657 DNA repair protein RadA; Provisional; Region: PRK11823 531844000658 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 531844000659 Walker A motif/ATP binding site; other site 531844000660 ATP binding site [chemical binding]; other site 531844000661 Walker B motif; other site 531844000662 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 531844000663 Protein of unknown function, DUF479; Region: DUF479; cl01203 531844000664 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 531844000665 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 531844000666 Zn binding site [ion binding]; other site 531844000667 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 531844000668 oligomerisation interface [polypeptide binding]; other site 531844000669 mobile loop; other site 531844000670 roof hairpin; other site 531844000671 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 531844000672 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 531844000673 ring oligomerisation interface [polypeptide binding]; other site 531844000674 ATP/Mg binding site [chemical binding]; other site 531844000675 stacking interactions; other site 531844000676 hinge regions; other site 531844000677 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 531844000678 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 531844000679 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 531844000680 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 531844000681 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 531844000682 RibD C-terminal domain; Region: RibD_C; cl17279 531844000683 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 531844000684 Part of AAA domain; Region: AAA_19; pfam13245 531844000685 putative recombination protein RecB; Provisional; Region: PRK13909 531844000686 Family description; Region: UvrD_C_2; pfam13538 531844000687 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 531844000688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 531844000689 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 531844000690 active site 531844000691 DNA binding site [nucleotide binding] 531844000692 Int/Topo IB signature motif; other site 531844000693 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 531844000694 30S subunit binding site; other site 531844000695 elongation factor Tu; Reviewed; Region: PRK12735 531844000696 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 531844000697 G1 box; other site 531844000698 GEF interaction site [polypeptide binding]; other site 531844000699 GTP/Mg2+ binding site [chemical binding]; other site 531844000700 Switch I region; other site 531844000701 G2 box; other site 531844000702 G3 box; other site 531844000703 Switch II region; other site 531844000704 G4 box; other site 531844000705 G5 box; other site 531844000706 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 531844000707 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 531844000708 Antibiotic Binding Site [chemical binding]; other site 531844000709 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 531844000710 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 531844000711 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 531844000712 putative homodimer interface [polypeptide binding]; other site 531844000713 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 531844000714 heterodimer interface [polypeptide binding]; other site 531844000715 homodimer interface [polypeptide binding]; other site 531844000716 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 531844000717 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 531844000718 23S rRNA interface [nucleotide binding]; other site 531844000719 L7/L12 interface [polypeptide binding]; other site 531844000720 putative thiostrepton binding site; other site 531844000721 L25 interface [polypeptide binding]; other site 531844000722 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 531844000723 mRNA/rRNA interface [nucleotide binding]; other site 531844000724 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 531844000725 23S rRNA interface [nucleotide binding]; other site 531844000726 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 531844000727 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 531844000728 peripheral dimer interface [polypeptide binding]; other site 531844000729 core dimer interface [polypeptide binding]; other site 531844000730 L10 interface [polypeptide binding]; other site 531844000731 L11 interface [polypeptide binding]; other site 531844000732 putative EF-Tu interaction site [polypeptide binding]; other site 531844000733 putative EF-G interaction site [polypeptide binding]; other site 531844000734 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 531844000735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 531844000736 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 531844000737 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 531844000738 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 531844000739 RPB12 interaction site [polypeptide binding]; other site 531844000740 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 531844000741 RPB3 interaction site [polypeptide binding]; other site 531844000742 RPB1 interaction site [polypeptide binding]; other site 531844000743 RPB11 interaction site [polypeptide binding]; other site 531844000744 RPB10 interaction site [polypeptide binding]; other site 531844000745 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 531844000746 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 531844000747 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 531844000748 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 531844000749 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 531844000750 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 531844000751 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 531844000752 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 531844000753 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 531844000754 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 531844000755 DNA binding site [nucleotide binding] 531844000756 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 531844000757 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 531844000758 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 531844000759 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 531844000760 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 531844000761 dimerization interface [polypeptide binding]; other site 531844000762 active site 531844000763 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 531844000764 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 531844000765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 531844000766 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 531844000767 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 531844000768 Tetramer interface [polypeptide binding]; other site 531844000769 active site 531844000770 FMN-binding site [chemical binding]; other site 531844000771 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 531844000772 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 531844000773 catalytic residues [active] 531844000774 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 531844000775 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 531844000776 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 531844000777 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 531844000778 putative catalytic residue [active] 531844000779 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 531844000780 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 531844000781 ferrochelatase; Reviewed; Region: hemH; PRK00035 531844000782 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 531844000783 C-terminal domain interface [polypeptide binding]; other site 531844000784 active site 531844000785 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 531844000786 active site 531844000787 N-terminal domain interface [polypeptide binding]; other site 531844000788 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 531844000789 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 531844000790 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 531844000791 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 531844000792 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 531844000793 trimer interface [polypeptide binding]; other site 531844000794 putative metal binding site [ion binding]; other site 531844000795 AAA domain; Region: AAA_22; pfam13401 531844000796 AAA domain; Region: AAA_30; pfam13604 531844000797 Family description; Region: UvrD_C_2; pfam13538 531844000798 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 531844000799 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 531844000800 putative active site [active] 531844000801 catalytic triad [active] 531844000802 putative dimer interface [polypeptide binding]; other site 531844000803 Dihydroneopterin aldolase; Region: FolB; pfam02152 531844000804 active site 531844000805 quinolinate synthetase; Provisional; Region: PRK09375 531844000806 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 531844000807 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 531844000808 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 531844000809 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 531844000810 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 531844000811 catalytic site [active] 531844000812 G-X2-G-X-G-K; other site 531844000813 hypothetical protein; Provisional; Region: PRK11820 531844000814 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 531844000815 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 531844000816 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 531844000817 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 531844000818 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 531844000819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 531844000820 RNA binding surface [nucleotide binding]; other site 531844000821 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 531844000822 active site 531844000823 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 531844000824 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 531844000825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844000826 FeS/SAM binding site; other site 531844000827 HemN C-terminal domain; Region: HemN_C; pfam06969 531844000828 glutamate racemase; Provisional; Region: PRK00865 531844000829 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 531844000830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844000831 S-adenosylmethionine binding site [chemical binding]; other site 531844000832 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 531844000833 Smr domain; Region: Smr; pfam01713 531844000834 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 531844000835 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 531844000836 dimer interface [polypeptide binding]; other site 531844000837 active site 531844000838 glycine-pyridoxal phosphate binding site [chemical binding]; other site 531844000839 folate binding site [chemical binding]; other site 531844000840 RecX family; Region: RecX; pfam02631 531844000841 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 531844000842 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 531844000843 SLBB domain; Region: SLBB; pfam10531 531844000844 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 531844000845 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 531844000846 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 531844000847 Nucleotide binding site [chemical binding]; other site 531844000848 P loop; other site 531844000849 DTAP/Switch II; other site 531844000850 Switch I; other site 531844000851 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 531844000852 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 531844000853 NAD binding site [chemical binding]; other site 531844000854 substrate binding site [chemical binding]; other site 531844000855 homodimer interface [polypeptide binding]; other site 531844000856 active site 531844000857 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 531844000858 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 531844000859 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 531844000860 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 531844000861 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 531844000862 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 531844000863 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 531844000864 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 531844000865 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 531844000866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000867 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 531844000868 putative ADP-binding pocket [chemical binding]; other site 531844000869 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844000870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000871 active site 531844000872 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 531844000873 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 531844000874 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 531844000875 inhibitor-cofactor binding pocket; inhibition site 531844000876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844000877 catalytic residue [active] 531844000878 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 531844000879 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 531844000880 putative trimer interface [polypeptide binding]; other site 531844000881 putative CoA binding site [chemical binding]; other site 531844000882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844000884 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844000885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000886 active site 531844000887 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 531844000888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000889 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 531844000890 putative ADP-binding pocket [chemical binding]; other site 531844000891 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 531844000892 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 531844000893 putative active site [active] 531844000894 putative metal binding site [ion binding]; other site 531844000895 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844000896 active site 531844000897 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 531844000898 putative ADP-binding pocket [chemical binding]; other site 531844000899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000900 Phosphopantetheine attachment site; Region: PP-binding; cl09936 531844000901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844000902 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 531844000903 NAD(P) binding site [chemical binding]; other site 531844000904 active site 531844000905 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 531844000906 active site 2 [active] 531844000907 dimer interface [polypeptide binding]; other site 531844000908 active site 1 [active] 531844000909 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 531844000910 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 531844000911 dimer interface [polypeptide binding]; other site 531844000912 active site 531844000913 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 531844000914 putative trimer interface [polypeptide binding]; other site 531844000915 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 531844000916 putative trimer interface [polypeptide binding]; other site 531844000917 putative CoA binding site [chemical binding]; other site 531844000918 putative CoA binding site [chemical binding]; other site 531844000919 Bacterial sugar transferase; Region: Bac_transf; pfam02397 531844000920 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 531844000921 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 531844000922 putative trimer interface [polypeptide binding]; other site 531844000923 putative CoA binding site [chemical binding]; other site 531844000924 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844000925 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 531844000926 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 531844000927 tyrosine kinase; Provisional; Region: PRK11519 531844000928 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 531844000929 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 531844000930 Nucleotide binding site [chemical binding]; other site 531844000931 P loop; other site 531844000932 DTAP/Switch II; other site 531844000933 Switch I; other site 531844000934 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 531844000935 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 531844000936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844000937 non-specific DNA binding site [nucleotide binding]; other site 531844000938 salt bridge; other site 531844000939 sequence-specific DNA binding site [nucleotide binding]; other site 531844000940 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 531844000941 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 531844000942 Walker A/P-loop; other site 531844000943 ATP binding site [chemical binding]; other site 531844000944 Q-loop/lid; other site 531844000945 ABC transporter signature motif; other site 531844000946 Walker B; other site 531844000947 D-loop; other site 531844000948 H-loop/switch region; other site 531844000949 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 531844000950 putative carbohydrate binding site [chemical binding]; other site 531844000951 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 531844000952 trimer interface [polypeptide binding]; other site 531844000953 active site 531844000954 substrate binding site [chemical binding]; other site 531844000955 CoA binding site [chemical binding]; other site 531844000956 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 531844000957 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 531844000958 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844000959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000961 active site 531844000962 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844000963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000964 active site 531844000965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000966 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 531844000967 putative ADP-binding pocket [chemical binding]; other site 531844000968 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844000969 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000970 active site 531844000971 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000972 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 531844000973 putative ADP-binding pocket [chemical binding]; other site 531844000974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000975 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 531844000976 putative ADP-binding pocket [chemical binding]; other site 531844000977 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 531844000978 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844000979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844000980 active site 531844000981 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000982 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 531844000983 putative ADP-binding pocket [chemical binding]; other site 531844000984 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 531844000985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844000986 putative ADP-binding pocket [chemical binding]; other site 531844000987 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844000988 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 531844000989 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 531844000990 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 531844000991 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 531844000992 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 531844000993 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 531844000994 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 531844000995 active site 531844000996 putative DNA-binding cleft [nucleotide binding]; other site 531844000997 dimer interface [polypeptide binding]; other site 531844000998 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 531844000999 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 531844001000 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 531844001001 Cu(I) binding site [ion binding]; other site 531844001002 Uncharacterized conserved protein [Function unknown]; Region: COG1262 531844001003 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 531844001004 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 531844001005 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 531844001006 Multicopper oxidase; Region: Cu-oxidase; pfam00394 531844001007 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844001008 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844001009 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844001010 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844001011 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 531844001012 Phage Tail Collar Domain; Region: Collar; pfam07484 531844001013 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 531844001014 Phage Tail Collar Domain; Region: Collar; pfam07484 531844001015 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001016 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 531844001017 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 531844001018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 531844001019 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 531844001020 active site 531844001021 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 531844001022 RuvA N terminal domain; Region: RuvA_N; pfam01330 531844001023 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 531844001024 cell surface protein SprA; Region: surface_SprA; TIGR04189 531844001025 Motility related/secretion protein; Region: SprA_N; pfam14349 531844001026 Motility related/secretion protein; Region: SprA_N; pfam14349 531844001027 Motility related/secretion protein; Region: SprA_N; pfam14349 531844001028 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 531844001029 GTP cyclohydrolase I; Provisional; Region: PLN03044 531844001030 active site 531844001031 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 531844001032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844001033 active site 531844001034 HIGH motif; other site 531844001035 nucleotide binding site [chemical binding]; other site 531844001036 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 531844001037 KMSKS motif; other site 531844001038 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 531844001039 tRNA binding surface [nucleotide binding]; other site 531844001040 anticodon binding site; other site 531844001041 4-alpha-glucanotransferase; Region: PLN02950 531844001042 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 531844001043 starch-binding site 2 [chemical binding]; other site 531844001044 starch-binding site 1 [chemical binding]; other site 531844001045 Starch binding domain; Region: CBM_2; smart01065 531844001046 starch-binding site 2 [chemical binding]; other site 531844001047 starch-binding site 1 [chemical binding]; other site 531844001048 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 531844001049 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 531844001050 Ferritin-like domain; Region: Ferritin; pfam00210 531844001051 ferroxidase diiron center [ion binding]; other site 531844001052 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 531844001053 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 531844001054 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 531844001055 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 531844001056 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 531844001057 Ligand Binding Site [chemical binding]; other site 531844001058 TilS substrate C-terminal domain; Region: TilS_C; smart00977 531844001059 Protein of unknown function (DUF904); Region: DUF904; pfam06005 531844001060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 531844001061 ligand binding site [chemical binding]; other site 531844001062 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 531844001063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844001064 S-adenosylmethionine binding site [chemical binding]; other site 531844001065 Bacterial SH3 domain; Region: SH3_3; cl17532 531844001066 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 531844001067 NlpC/P60 family; Region: NLPC_P60; pfam00877 531844001068 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 531844001069 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 531844001070 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 531844001071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844001072 active site 531844001073 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 531844001074 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 531844001075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844001076 active site 531844001077 HIGH motif; other site 531844001078 nucleotide binding site [chemical binding]; other site 531844001079 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844001080 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 531844001081 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844001082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844001083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844001084 active site 531844001085 KMSKS motif; other site 531844001086 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 531844001087 tRNA binding surface [nucleotide binding]; other site 531844001088 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 531844001089 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 531844001090 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 531844001091 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 531844001092 PBP superfamily domain; Region: PBP_like_2; pfam12849 531844001093 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 531844001094 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 531844001095 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 531844001096 active sites [active] 531844001097 tetramer interface [polypeptide binding]; other site 531844001098 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 531844001099 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 531844001100 GIY-YIG motif/motif A; other site 531844001101 active site 531844001102 catalytic site [active] 531844001103 putative DNA binding site [nucleotide binding]; other site 531844001104 metal binding site [ion binding]; metal-binding site 531844001105 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 531844001106 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 531844001107 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 531844001108 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 531844001109 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 531844001110 putative active site [active] 531844001111 metal binding site [ion binding]; metal-binding site 531844001112 Uncharacterized conserved protein [Function unknown]; Region: COG2353 531844001113 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 531844001114 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 531844001115 active site 531844001116 Zn binding site [ion binding]; other site 531844001117 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 531844001118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844001119 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 531844001120 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 531844001121 fumarylacetoacetase; Region: PLN02856 531844001122 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 531844001123 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 531844001124 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 531844001125 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 531844001126 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 531844001127 active site 531844001128 Fe binding site [ion binding]; other site 531844001129 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844001130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844001131 ligand binding site [chemical binding]; other site 531844001132 flexible hinge region; other site 531844001133 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 531844001134 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 531844001135 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 531844001136 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 531844001137 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 531844001138 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 531844001139 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 531844001140 RNase E interface [polypeptide binding]; other site 531844001141 trimer interface [polypeptide binding]; other site 531844001142 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 531844001143 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 531844001144 RNase E interface [polypeptide binding]; other site 531844001145 trimer interface [polypeptide binding]; other site 531844001146 active site 531844001147 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 531844001148 RNA binding site [nucleotide binding]; other site 531844001149 domain interface; other site 531844001150 Transposase IS200 like; Region: Y1_Tnp; pfam01797 531844001151 HopJ type III effector protein; Region: HopJ; pfam08888 531844001152 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 531844001153 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 531844001154 FMN binding site [chemical binding]; other site 531844001155 substrate binding site [chemical binding]; other site 531844001156 putative catalytic residue [active] 531844001157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 531844001158 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 531844001159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 531844001160 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 531844001161 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 531844001162 substrate binding site [chemical binding]; other site 531844001163 ATP binding site [chemical binding]; other site 531844001164 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 531844001165 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 531844001166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 531844001167 minor groove reading motif; other site 531844001168 helix-hairpin-helix signature motif; other site 531844001169 substrate binding pocket [chemical binding]; other site 531844001170 active site 531844001171 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 531844001172 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 531844001173 DNA binding and oxoG recognition site [nucleotide binding] 531844001174 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 531844001175 IHF dimer interface [polypeptide binding]; other site 531844001176 IHF - DNA interface [nucleotide binding]; other site 531844001177 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 531844001178 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 531844001179 homodimer interface [polypeptide binding]; other site 531844001180 oligonucleotide binding site [chemical binding]; other site 531844001181 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 531844001182 putative active site [active] 531844001183 putative CoA binding site [chemical binding]; other site 531844001184 nudix motif; other site 531844001185 metal binding site [ion binding]; metal-binding site 531844001186 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 531844001187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 531844001188 putative acyl-acceptor binding pocket; other site 531844001189 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 531844001190 16S/18S rRNA binding site [nucleotide binding]; other site 531844001191 S13e-L30e interaction site [polypeptide binding]; other site 531844001192 25S rRNA binding site [nucleotide binding]; other site 531844001193 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 531844001194 MgtE intracellular N domain; Region: MgtE_N; pfam03448 531844001195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 531844001196 Divalent cation transporter; Region: MgtE; pfam01769 531844001197 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 531844001198 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 531844001199 intersubunit interface [polypeptide binding]; other site 531844001200 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 531844001201 dihydrodipicolinate synthase; Region: dapA; TIGR00674 531844001202 dimer interface [polypeptide binding]; other site 531844001203 active site 531844001204 catalytic residue [active] 531844001205 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 531844001206 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 531844001207 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 531844001208 active site 531844001209 metal binding site [ion binding]; metal-binding site 531844001210 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 531844001211 Recombination protein O N terminal; Region: RecO_N; pfam11967 531844001212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 531844001213 RNA binding surface [nucleotide binding]; other site 531844001214 shikimate kinase; Reviewed; Region: aroK; PRK00131 531844001215 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 531844001216 ADP binding site [chemical binding]; other site 531844001217 magnesium binding site [ion binding]; other site 531844001218 putative shikimate binding site; other site 531844001219 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 531844001220 pantoate--beta-alanine ligase; Region: panC; TIGR00018 531844001221 active site 531844001222 nucleotide binding site [chemical binding]; other site 531844001223 HIGH motif; other site 531844001224 KMSKS motif; other site 531844001225 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 531844001226 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 531844001227 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 531844001228 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 531844001229 glutaminase active site [active] 531844001230 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 531844001231 dimer interface [polypeptide binding]; other site 531844001232 active site 531844001233 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 531844001234 dimer interface [polypeptide binding]; other site 531844001235 active site 531844001236 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 531844001237 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 531844001238 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 531844001239 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 531844001240 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 531844001241 GldM N-terminal domain; Region: GldM_N; pfam12081 531844001242 GldM C-terminal domain; Region: GldM_C; pfam12080 531844001243 gliding motility associated protien GldN; Region: GldN; TIGR03523 531844001244 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 531844001245 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 531844001246 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 531844001247 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001248 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 531844001249 active site 531844001250 homodimer interface [polypeptide binding]; other site 531844001251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 531844001252 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 531844001253 UGMP family protein; Validated; Region: PRK09604 531844001254 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 531844001255 Family of unknown function (DUF490); Region: DUF490; pfam04357 531844001256 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 531844001257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 531844001258 putative DNA binding site [nucleotide binding]; other site 531844001259 putative Zn2+ binding site [ion binding]; other site 531844001260 AsnC family; Region: AsnC_trans_reg; pfam01037 531844001261 Rrf2 family protein; Region: rrf2_super; TIGR00738 531844001262 Transcriptional regulator; Region: Rrf2; pfam02082 531844001263 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 531844001264 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 531844001265 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 531844001266 Protein of unknown function, DUF488; Region: DUF488; pfam04343 531844001267 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 531844001268 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 531844001269 PYR/PP interface [polypeptide binding]; other site 531844001270 dimer interface [polypeptide binding]; other site 531844001271 TPP binding site [chemical binding]; other site 531844001272 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 531844001273 transketolase; Reviewed; Region: PRK05899 531844001274 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 531844001275 TPP-binding site [chemical binding]; other site 531844001276 dimer interface [polypeptide binding]; other site 531844001277 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 531844001278 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 531844001279 motif 1; other site 531844001280 active site 531844001281 motif 2; other site 531844001282 motif 3; other site 531844001283 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 531844001284 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 531844001285 phosphodiesterase YaeI; Provisional; Region: PRK11340 531844001286 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 531844001287 putative active site [active] 531844001288 putative metal binding site [ion binding]; other site 531844001289 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 531844001290 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 531844001291 dimer interface [polypeptide binding]; other site 531844001292 active site 531844001293 CoA binding pocket [chemical binding]; other site 531844001294 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 531844001295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844001296 S-adenosylmethionine binding site [chemical binding]; other site 531844001297 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844001298 Cell division protein ZapA; Region: ZapA; pfam05164 531844001299 phosphodiesterase; Provisional; Region: PRK12704 531844001300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 531844001301 Zn2+ binding site [ion binding]; other site 531844001302 Mg2+ binding site [ion binding]; other site 531844001303 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 531844001304 ArsC family; Region: ArsC; pfam03960 531844001305 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 531844001306 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 531844001307 putative dimer interface [polypeptide binding]; other site 531844001308 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 531844001309 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 531844001310 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 531844001311 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 531844001312 active site 531844001313 metal binding site [ion binding]; metal-binding site 531844001314 nudix motif; other site 531844001315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844001316 active site 531844001317 motif I; other site 531844001318 motif II; other site 531844001319 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 531844001320 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 531844001321 putative ligand binding site [chemical binding]; other site 531844001322 NAD binding site [chemical binding]; other site 531844001323 dimerization interface [polypeptide binding]; other site 531844001324 catalytic site [active] 531844001325 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 531844001326 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 531844001327 putative carbohydrate kinase; Provisional; Region: PRK10565 531844001328 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 531844001329 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 531844001330 putative substrate binding site [chemical binding]; other site 531844001331 putative ATP binding site [chemical binding]; other site 531844001332 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 531844001333 Haemolytic domain; Region: Haemolytic; pfam01809 531844001334 recombination factor protein RarA; Reviewed; Region: PRK13342 531844001335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844001336 Walker A motif; other site 531844001337 ATP binding site [chemical binding]; other site 531844001338 Walker B motif; other site 531844001339 arginine finger; other site 531844001340 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 531844001341 prephenate dehydratase; Provisional; Region: PRK11898 531844001342 Prephenate dehydratase; Region: PDT; pfam00800 531844001343 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 531844001344 putative L-Phe binding site [chemical binding]; other site 531844001345 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 531844001346 active site 531844001347 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 531844001348 sugar binding site [chemical binding]; other site 531844001349 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 531844001350 active site pocket [active] 531844001351 oxyanion hole [active] 531844001352 catalytic triad [active] 531844001353 active site nucleophile [active] 531844001354 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 531844001355 active site 531844001356 DnaA N-terminal domain; Region: DnaA_N; pfam11638 531844001357 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 531844001358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844001359 Walker A motif; other site 531844001360 ATP binding site [chemical binding]; other site 531844001361 Walker B motif; other site 531844001362 arginine finger; other site 531844001363 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 531844001364 DnaA box-binding interface [nucleotide binding]; other site 531844001365 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 531844001366 Low molecular weight phosphatase family; Region: LMWPc; cd00115 531844001367 active site 531844001368 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 531844001369 putative SAM binding site [chemical binding]; other site 531844001370 homodimer interface [polypeptide binding]; other site 531844001371 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 531844001372 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 531844001373 active site 531844001374 HIGH motif; other site 531844001375 KMSKS motif; other site 531844001376 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 531844001377 tRNA binding surface [nucleotide binding]; other site 531844001378 anticodon binding site; other site 531844001379 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 531844001380 dimer interface [polypeptide binding]; other site 531844001381 putative tRNA-binding site [nucleotide binding]; other site 531844001382 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844001383 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844001384 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844001385 SusE outer membrane protein; Region: SusE; pfam14292 531844001386 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 531844001387 starch binding site [chemical binding]; other site 531844001388 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 531844001389 starch binding site [chemical binding]; other site 531844001390 SusE outer membrane protein; Region: SusE; pfam14292 531844001391 SusE outer membrane protein; Region: SusE; pfam14292 531844001392 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 531844001393 starch binding site [chemical binding]; other site 531844001394 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 531844001395 starch binding site [chemical binding]; other site 531844001396 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 531844001397 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 531844001398 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 531844001399 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 531844001400 Ca binding site [ion binding]; other site 531844001401 active site 531844001402 homodimer interface [polypeptide binding]; other site 531844001403 catalytic site [active] 531844001404 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 531844001405 SnoaL-like domain; Region: SnoaL_3; pfam13474 531844001406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844001407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 531844001408 putative substrate translocation pore; other site 531844001409 Pirin-related protein [General function prediction only]; Region: COG1741 531844001410 Pirin; Region: Pirin; pfam02678 531844001411 Protein of unknown function (DUF808); Region: DUF808; cl01002 531844001412 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 531844001413 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 531844001414 dimerization interface [polypeptide binding]; other site 531844001415 putative ATP binding site [chemical binding]; other site 531844001416 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 531844001417 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 531844001418 active site 531844001419 substrate binding site [chemical binding]; other site 531844001420 cosubstrate binding site; other site 531844001421 catalytic site [active] 531844001422 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 531844001423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 531844001424 active site 531844001425 metal binding site [ion binding]; metal-binding site 531844001426 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 531844001427 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 531844001428 purine monophosphate binding site [chemical binding]; other site 531844001429 dimer interface [polypeptide binding]; other site 531844001430 putative catalytic residues [active] 531844001431 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 531844001432 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 531844001433 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 531844001434 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 531844001435 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 531844001436 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 531844001437 GMP synthase; Reviewed; Region: guaA; PRK00074 531844001438 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 531844001439 AMP/PPi binding site [chemical binding]; other site 531844001440 candidate oxyanion hole; other site 531844001441 catalytic triad [active] 531844001442 potential glutamine specificity residues [chemical binding]; other site 531844001443 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 531844001444 ATP Binding subdomain [chemical binding]; other site 531844001445 Ligand Binding sites [chemical binding]; other site 531844001446 Dimerization subdomain; other site 531844001447 helicase 45; Provisional; Region: PTZ00424 531844001448 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 531844001449 ATP binding site [chemical binding]; other site 531844001450 Mg++ binding site [ion binding]; other site 531844001451 motif III; other site 531844001452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844001453 nucleotide binding region [chemical binding]; other site 531844001454 ATP-binding site [chemical binding]; other site 531844001455 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 531844001456 active site 531844001457 catalytic triad [active] 531844001458 oxyanion hole [active] 531844001459 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 531844001460 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 531844001461 homotetramer interface [polypeptide binding]; other site 531844001462 ligand binding site [chemical binding]; other site 531844001463 catalytic site [active] 531844001464 NAD binding site [chemical binding]; other site 531844001465 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 531844001466 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 531844001467 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 531844001468 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 531844001469 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 531844001470 active site 531844001471 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 531844001472 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 531844001473 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 531844001474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844001475 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844001476 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 531844001477 active site 531844001478 Ap6A binding site [chemical binding]; other site 531844001479 nudix motif; other site 531844001480 metal binding site [ion binding]; metal-binding site 531844001481 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 531844001482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844001483 Walker A/P-loop; other site 531844001484 ATP binding site [chemical binding]; other site 531844001485 Q-loop/lid; other site 531844001486 ABC transporter signature motif; other site 531844001487 Walker B; other site 531844001488 D-loop; other site 531844001489 H-loop/switch region; other site 531844001490 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 531844001491 GIY-YIG motif/motif A; other site 531844001492 active site 531844001493 catalytic site [active] 531844001494 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 531844001495 GIY-YIG motif/motif A; other site 531844001496 putative active site [active] 531844001497 putative metal binding site [ion binding]; other site 531844001498 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 531844001499 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 531844001500 amidase catalytic site [active] 531844001501 Zn binding residues [ion binding]; other site 531844001502 substrate binding site [chemical binding]; other site 531844001503 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 531844001504 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 531844001505 Aspartase; Region: Aspartase; cd01357 531844001506 active sites [active] 531844001507 tetramer interface [polypeptide binding]; other site 531844001508 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 531844001509 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 531844001510 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 531844001511 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 531844001512 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 531844001513 Peptidase S46; Region: Peptidase_S46; pfam10459 531844001514 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 531844001515 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 531844001516 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 531844001517 Putative esterase; Region: Esterase; pfam00756 531844001518 glycogen branching enzyme; Provisional; Region: PRK12313 531844001519 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 531844001520 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 531844001521 active site 531844001522 catalytic site [active] 531844001523 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 531844001524 glycogen synthase; Provisional; Region: glgA; PRK00654 531844001525 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 531844001526 ADP-binding pocket [chemical binding]; other site 531844001527 homodimer interface [polypeptide binding]; other site 531844001528 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 531844001529 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 531844001530 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 531844001531 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 531844001532 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 531844001533 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 531844001534 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 531844001535 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 531844001536 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 531844001537 active site 531844001538 catalytic residues [active] 531844001539 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001540 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 531844001541 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 531844001542 inhibitor-cofactor binding pocket; inhibition site 531844001543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844001544 catalytic residue [active] 531844001545 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 531844001546 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 531844001547 NAD binding site [chemical binding]; other site 531844001548 homodimer interface [polypeptide binding]; other site 531844001549 active site 531844001550 substrate binding site [chemical binding]; other site 531844001551 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 531844001552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844001553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844001554 YceG-like family; Region: YceG; pfam02618 531844001555 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 531844001556 dimerization interface [polypeptide binding]; other site 531844001557 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 531844001558 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 531844001559 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 531844001560 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 531844001561 amino acid transporter; Region: 2A0306; TIGR00909 531844001562 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 531844001563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 531844001564 active site 531844001565 DNA binding site [nucleotide binding] 531844001566 Int/Topo IB signature motif; other site 531844001567 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 531844001568 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 531844001569 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 531844001570 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 531844001571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844001572 TPR motif; other site 531844001573 TPR repeat; Region: TPR_11; pfam13414 531844001574 binding surface 531844001575 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 531844001576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844001577 FeS/SAM binding site; other site 531844001578 HemN C-terminal domain; Region: HemN_C; pfam06969 531844001579 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 531844001580 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001581 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 531844001582 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 531844001583 Protein export membrane protein; Region: SecD_SecF; pfam02355 531844001584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844001585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 531844001586 putative substrate translocation pore; other site 531844001587 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 531844001588 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 531844001589 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 531844001590 active site 531844001591 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 531844001592 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 531844001593 Putative amidase domain; Region: Amidase_6; pfam12671 531844001594 Uncharacterized conserved protein [Function unknown]; Region: COG2353 531844001595 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 531844001596 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 531844001597 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 531844001598 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 531844001599 catalytic residues [active] 531844001600 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 531844001601 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 531844001602 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 531844001603 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 531844001604 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 531844001605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 531844001606 Coenzyme A binding pocket [chemical binding]; other site 531844001607 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 531844001608 catalytic residues [active] 531844001609 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 531844001610 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 531844001611 dimer interface [polypeptide binding]; other site 531844001612 decamer (pentamer of dimers) interface [polypeptide binding]; other site 531844001613 catalytic triad [active] 531844001614 peroxidatic and resolving cysteines [active] 531844001615 Haem-binding domain; Region: Haem_bd; pfam14376 531844001616 Protein of unknown function, DUF393; Region: DUF393; pfam04134 531844001617 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 531844001618 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 531844001619 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 531844001620 hinge; other site 531844001621 active site 531844001622 GTP-binding protein Der; Reviewed; Region: PRK00093 531844001623 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 531844001624 G1 box; other site 531844001625 GTP/Mg2+ binding site [chemical binding]; other site 531844001626 Switch I region; other site 531844001627 G2 box; other site 531844001628 Switch II region; other site 531844001629 G3 box; other site 531844001630 G4 box; other site 531844001631 G5 box; other site 531844001632 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 531844001633 G1 box; other site 531844001634 GTP/Mg2+ binding site [chemical binding]; other site 531844001635 Switch I region; other site 531844001636 G2 box; other site 531844001637 G3 box; other site 531844001638 Switch II region; other site 531844001639 G4 box; other site 531844001640 G5 box; other site 531844001641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844001642 active site 531844001643 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 531844001644 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844001645 active site 531844001646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 531844001647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844001648 non-specific DNA binding site [nucleotide binding]; other site 531844001649 salt bridge; other site 531844001650 sequence-specific DNA binding site [nucleotide binding]; other site 531844001651 malate synthase A; Region: malate_syn_A; TIGR01344 531844001652 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 531844001653 active site 531844001654 isocitrate lyase; Provisional; Region: PRK15063 531844001655 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 531844001656 tetramer interface [polypeptide binding]; other site 531844001657 active site 531844001658 Mg2+/Mn2+ binding site [ion binding]; other site 531844001659 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 531844001660 active site 531844001661 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 531844001662 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 531844001663 putative active site [active] 531844001664 putative metal binding site [ion binding]; other site 531844001665 GxxExxY protein; Region: GxxExxY; TIGR04256 531844001666 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 531844001667 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 531844001668 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 531844001669 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 531844001670 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 531844001671 active site 531844001672 catalytic site [active] 531844001673 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001674 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 531844001675 helicase 45; Provisional; Region: PTZ00424 531844001676 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 531844001677 ATP binding site [chemical binding]; other site 531844001678 Mg++ binding site [ion binding]; other site 531844001679 motif III; other site 531844001680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844001681 nucleotide binding region [chemical binding]; other site 531844001682 ATP-binding site [chemical binding]; other site 531844001683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 531844001684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844001685 DNA binding residues [nucleotide binding] 531844001686 dimerization interface [polypeptide binding]; other site 531844001687 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 531844001688 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 531844001689 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 531844001690 6-phosphofructokinase; Provisional; Region: PRK03202 531844001691 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 531844001692 active site 531844001693 ADP/pyrophosphate binding site [chemical binding]; other site 531844001694 dimerization interface [polypeptide binding]; other site 531844001695 allosteric effector site; other site 531844001696 fructose-1,6-bisphosphate binding site; other site 531844001697 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844001698 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844001699 trigger factor; Region: tig; TIGR00115 531844001700 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 531844001701 MgtC family; Region: MgtC; pfam02308 531844001702 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 531844001703 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 531844001704 Ligand Binding Site [chemical binding]; other site 531844001705 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 531844001706 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 531844001707 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 531844001708 active site 531844001709 catalytic site [active] 531844001710 substrate binding site [chemical binding]; other site 531844001711 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 531844001712 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 531844001713 Sulfatase; Region: Sulfatase; cl17466 531844001714 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 531844001715 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 531844001716 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 531844001717 alpha subunit interface [polypeptide binding]; other site 531844001718 TPP binding site [chemical binding]; other site 531844001719 heterodimer interface [polypeptide binding]; other site 531844001720 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 531844001721 K+ potassium transporter; Region: K_trans; pfam02705 531844001722 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 531844001723 metal binding site 2 [ion binding]; metal-binding site 531844001724 putative DNA binding helix; other site 531844001725 metal binding site 1 [ion binding]; metal-binding site 531844001726 dimer interface [polypeptide binding]; other site 531844001727 structural Zn2+ binding site [ion binding]; other site 531844001728 OstA-like protein; Region: OstA_2; pfam13100 531844001729 OstA-like protein; Region: OstA; cl00844 531844001730 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 531844001731 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 531844001732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 531844001733 inhibitor-cofactor binding pocket; inhibition site 531844001734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844001735 catalytic residue [active] 531844001736 homodimer interface [polypeptide binding]; other site 531844001737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844001738 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 531844001739 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 531844001740 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 531844001741 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 531844001742 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 531844001743 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 531844001744 IHF - DNA interface [nucleotide binding]; other site 531844001745 IHF dimer interface [polypeptide binding]; other site 531844001746 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 531844001747 tetramerization interface [polypeptide binding]; other site 531844001748 active site 531844001749 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 531844001750 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 531844001751 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 531844001752 active site 531844001753 Zn binding site [ion binding]; other site 531844001754 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 531844001755 putative hydrophobic ligand binding site [chemical binding]; other site 531844001756 Predicted permeases [General function prediction only]; Region: RarD; COG2962 531844001757 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 531844001758 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844001759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844001760 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 531844001761 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 531844001762 dimer interface [polypeptide binding]; other site 531844001763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844001764 catalytic residue [active] 531844001765 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 531844001766 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 531844001767 FtsX-like permease family; Region: FtsX; pfam02687 531844001768 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 531844001769 Pleckstrin homology-like domain; Region: PH-like; cl17171 531844001770 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001771 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844001772 DNA polymerase I; Provisional; Region: PRK05755 531844001773 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 531844001774 active site 531844001775 metal binding site 1 [ion binding]; metal-binding site 531844001776 putative 5' ssDNA interaction site; other site 531844001777 metal binding site 3; metal-binding site 531844001778 metal binding site 2 [ion binding]; metal-binding site 531844001779 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 531844001780 putative DNA binding site [nucleotide binding]; other site 531844001781 putative metal binding site [ion binding]; other site 531844001782 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 531844001783 active site 531844001784 catalytic site [active] 531844001785 substrate binding site [chemical binding]; other site 531844001786 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 531844001787 active site 531844001788 DNA binding site [nucleotide binding] 531844001789 catalytic site [active] 531844001790 YCII-related domain; Region: YCII; cl00999 531844001791 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 531844001792 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 531844001793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844001794 DXD motif; other site 531844001795 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 531844001796 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 531844001797 active site 531844001798 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844001799 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 531844001800 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 531844001801 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 531844001802 active site 531844001803 catalytic site [active] 531844001804 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 531844001805 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 531844001806 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 531844001807 helicase 45; Provisional; Region: PTZ00424 531844001808 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 531844001809 ATP binding site [chemical binding]; other site 531844001810 Mg++ binding site [ion binding]; other site 531844001811 motif III; other site 531844001812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844001813 nucleotide binding region [chemical binding]; other site 531844001814 ATP-binding site [chemical binding]; other site 531844001815 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 531844001816 RNA binding site [nucleotide binding]; other site 531844001817 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 531844001818 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 531844001819 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 531844001820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 531844001821 substrate binding pocket [chemical binding]; other site 531844001822 chain length determination region; other site 531844001823 substrate-Mg2+ binding site; other site 531844001824 catalytic residues [active] 531844001825 aspartate-rich region 1; other site 531844001826 active site lid residues [active] 531844001827 aspartate-rich region 2; other site 531844001828 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 531844001829 active site 531844001830 catalytic triad [active] 531844001831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 531844001832 Coenzyme A binding pocket [chemical binding]; other site 531844001833 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 531844001834 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 531844001835 active site 531844001836 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 531844001837 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 531844001838 ATP binding site [chemical binding]; other site 531844001839 Mg++ binding site [ion binding]; other site 531844001840 motif III; other site 531844001841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844001842 nucleotide binding region [chemical binding]; other site 531844001843 ATP-binding site [chemical binding]; other site 531844001844 GTPase CgtA; Reviewed; Region: obgE; PRK12299 531844001845 GTP1/OBG; Region: GTP1_OBG; pfam01018 531844001846 Obg GTPase; Region: Obg; cd01898 531844001847 G1 box; other site 531844001848 GTP/Mg2+ binding site [chemical binding]; other site 531844001849 Switch I region; other site 531844001850 G2 box; other site 531844001851 G3 box; other site 531844001852 Switch II region; other site 531844001853 G4 box; other site 531844001854 G5 box; other site 531844001855 adenylate kinase; Reviewed; Region: adk; PRK00279 531844001856 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 531844001857 AMP-binding site [chemical binding]; other site 531844001858 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 531844001859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844001860 active site 531844001861 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 531844001862 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 531844001863 GDP-binding site [chemical binding]; other site 531844001864 ACT binding site; other site 531844001865 IMP binding site; other site 531844001866 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 531844001867 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 531844001868 Gram-negative bacterial tonB protein; Region: TonB; cl10048 531844001869 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 531844001870 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 531844001871 P-loop; other site 531844001872 Magnesium ion binding site [ion binding]; other site 531844001873 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 531844001874 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 531844001875 ParB-like nuclease domain; Region: ParB; smart00470 531844001876 dihydrodipicolinate reductase; Provisional; Region: PRK00048 531844001877 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 531844001878 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 531844001879 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 531844001880 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 531844001881 Catalytic site [active] 531844001882 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 531844001883 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 531844001884 WbqC-like protein family; Region: WbqC; pfam08889 531844001885 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 531844001886 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 531844001887 active site 531844001888 catalytic residues [active] 531844001889 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 531844001890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 531844001891 ligand binding site [chemical binding]; other site 531844001892 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 531844001893 FAD binding domain; Region: FAD_binding_4; pfam01565 531844001894 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 531844001895 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 531844001896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844001897 active site 531844001898 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 531844001899 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 531844001900 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 531844001901 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 531844001902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 531844001903 catalytic residue [active] 531844001904 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 531844001905 catalytic residues [active] 531844001906 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 531844001907 GIY-YIG motif/motif A; other site 531844001908 putative active site [active] 531844001909 putative metal binding site [ion binding]; other site 531844001910 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 531844001911 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 531844001912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844001913 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 531844001914 putative active site [active] 531844001915 heme pocket [chemical binding]; other site 531844001916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844001917 putative active site [active] 531844001918 heme pocket [chemical binding]; other site 531844001919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844001920 dimer interface [polypeptide binding]; other site 531844001921 phosphorylation site [posttranslational modification] 531844001922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844001923 ATP binding site [chemical binding]; other site 531844001924 Mg2+ binding site [ion binding]; other site 531844001925 G-X-G motif; other site 531844001926 Response regulator receiver domain; Region: Response_reg; pfam00072 531844001927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844001928 active site 531844001929 phosphorylation site [posttranslational modification] 531844001930 intermolecular recognition site; other site 531844001931 dimerization interface [polypeptide binding]; other site 531844001932 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 531844001933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844001934 active site 531844001935 phosphorylation site [posttranslational modification] 531844001936 intermolecular recognition site; other site 531844001937 dimerization interface [polypeptide binding]; other site 531844001938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844001939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844001940 ATP binding site [chemical binding]; other site 531844001941 Mg2+ binding site [ion binding]; other site 531844001942 G-X-G motif; other site 531844001943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 531844001944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844001945 active site 531844001946 phosphorylation site [posttranslational modification] 531844001947 intermolecular recognition site; other site 531844001948 dimerization interface [polypeptide binding]; other site 531844001949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844001950 DNA binding residues [nucleotide binding] 531844001951 dimerization interface [polypeptide binding]; other site 531844001952 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 531844001953 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 531844001954 ligand binding site; other site 531844001955 oligomer interface; other site 531844001956 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 531844001957 dimer interface [polypeptide binding]; other site 531844001958 N-terminal domain interface [polypeptide binding]; other site 531844001959 sulfate 1 binding site; other site 531844001960 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 531844001961 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 531844001962 TPP-binding site [chemical binding]; other site 531844001963 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 531844001964 PYR/PP interface [polypeptide binding]; other site 531844001965 dimer interface [polypeptide binding]; other site 531844001966 TPP binding site [chemical binding]; other site 531844001967 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 531844001968 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 531844001969 E3 interaction surface; other site 531844001970 lipoyl attachment site [posttranslational modification]; other site 531844001971 e3 binding domain; Region: E3_binding; pfam02817 531844001972 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 531844001973 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 531844001974 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 531844001975 active site 531844001976 catalytic site [active] 531844001977 substrate binding site [chemical binding]; other site 531844001978 Domain of unknown function DUF21; Region: DUF21; pfam01595 531844001979 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 531844001980 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 531844001981 Transporter associated domain; Region: CorC_HlyC; smart01091 531844001982 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 531844001983 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 531844001984 Probable Catalytic site; other site 531844001985 metal-binding site 531844001986 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 531844001987 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 531844001988 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 531844001989 putative acyl-acceptor binding pocket; other site 531844001990 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 531844001991 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 531844001992 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 531844001993 NAD(P) binding site [chemical binding]; other site 531844001994 catalytic residues [active] 531844001995 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 531844001996 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 531844001997 tetramer interface [polypeptide binding]; other site 531844001998 active site 531844001999 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 531844002000 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 531844002001 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 531844002002 dimerization interface [polypeptide binding]; other site 531844002003 ATP binding site [chemical binding]; other site 531844002004 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 531844002005 dimerization interface [polypeptide binding]; other site 531844002006 ATP binding site [chemical binding]; other site 531844002007 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 531844002008 conserved cys residue [active] 531844002009 MarR family; Region: MarR_2; pfam12802 531844002010 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 531844002011 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 531844002012 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 531844002013 ATP binding site [chemical binding]; other site 531844002014 active site 531844002015 substrate binding site [chemical binding]; other site 531844002016 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 531844002017 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 531844002018 active site 531844002019 tetramer interface [polypeptide binding]; other site 531844002020 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844002021 active site 531844002022 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844002023 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 531844002024 active site 531844002025 dimer interface [polypeptide binding]; other site 531844002026 metal binding site [ion binding]; metal-binding site 531844002027 Proline dehydrogenase; Region: Pro_dh; cl03282 531844002028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844002029 primosomal protein N' Region: priA; TIGR00595 531844002030 ATP binding site [chemical binding]; other site 531844002031 putative Mg++ binding site [ion binding]; other site 531844002032 helicase superfamily c-terminal domain; Region: HELICc; smart00490 531844002033 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 531844002034 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 531844002035 Peptidase family M1; Region: Peptidase_M1; pfam01433 531844002036 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 531844002037 Zn binding site [ion binding]; other site 531844002038 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002039 SnoaL-like domain; Region: SnoaL_3; pfam13474 531844002040 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 531844002041 Cupin domain; Region: Cupin_2; pfam07883 531844002042 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 531844002043 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 531844002044 substrate-cofactor binding pocket; other site 531844002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002046 catalytic residue [active] 531844002047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 531844002048 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 531844002049 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844002050 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844002051 ligand binding site [chemical binding]; other site 531844002052 flexible hinge region; other site 531844002053 putative switch regulator; other site 531844002054 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 531844002055 non-specific DNA interactions [nucleotide binding]; other site 531844002056 DNA binding site [nucleotide binding] 531844002057 sequence specific DNA binding site [nucleotide binding]; other site 531844002058 putative cAMP binding site [chemical binding]; other site 531844002059 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 531844002060 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 531844002061 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 531844002062 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 531844002063 Aspartase; Region: Aspartase; cd01357 531844002064 active sites [active] 531844002065 tetramer interface [polypeptide binding]; other site 531844002066 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 531844002067 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 531844002068 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 531844002069 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 531844002070 Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562 531844002071 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 531844002072 active site 531844002073 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 531844002074 heterodimerization interface [polypeptide binding]; other site 531844002075 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002076 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 531844002077 PhoH-like protein; Region: PhoH; pfam02562 531844002078 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 531844002079 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844002080 signal recognition particle protein; Provisional; Region: PRK10867 531844002081 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 531844002082 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 531844002083 P loop; other site 531844002084 GTP binding site [chemical binding]; other site 531844002085 Signal peptide binding domain; Region: SRP_SPB; pfam02978 531844002086 ATP synthase A chain; Region: ATP-synt_A; cl00413 531844002087 ATP synthase subunit C; Region: ATP-synt_C; cl00466 531844002088 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 531844002089 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 531844002090 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 531844002091 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 531844002092 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 531844002093 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 531844002094 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 531844002095 beta subunit interaction interface [polypeptide binding]; other site 531844002096 Walker A motif; other site 531844002097 ATP binding site [chemical binding]; other site 531844002098 Walker B motif; other site 531844002099 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 531844002100 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 531844002101 core domain interface [polypeptide binding]; other site 531844002102 delta subunit interface [polypeptide binding]; other site 531844002103 epsilon subunit interface [polypeptide binding]; other site 531844002104 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 531844002105 Domain of unknown function DUF21; Region: DUF21; pfam01595 531844002106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 531844002107 Transporter associated domain; Region: CorC_HlyC; smart01091 531844002108 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 531844002109 Rhomboid family; Region: Rhomboid; cl11446 531844002110 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 531844002111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844002112 S-adenosylmethionine binding site [chemical binding]; other site 531844002113 NlpC/P60 family; Region: NLPC_P60; pfam00877 531844002114 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 531844002115 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 531844002116 trimer interface [polypeptide binding]; other site 531844002117 active site 531844002118 substrate binding site [chemical binding]; other site 531844002119 CoA binding site [chemical binding]; other site 531844002120 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 531844002121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844002122 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 531844002123 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 531844002124 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 531844002125 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 531844002126 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 531844002127 histidinol dehydrogenase; Region: hisD; TIGR00069 531844002128 NAD binding site [chemical binding]; other site 531844002129 dimerization interface [polypeptide binding]; other site 531844002130 product binding site; other site 531844002131 substrate binding site [chemical binding]; other site 531844002132 zinc binding site [ion binding]; other site 531844002133 catalytic residues [active] 531844002134 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 531844002135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 531844002136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002137 homodimer interface [polypeptide binding]; other site 531844002138 catalytic residue [active] 531844002139 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 531844002140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844002141 active site 531844002142 motif I; other site 531844002143 motif II; other site 531844002144 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 531844002145 putative active site pocket [active] 531844002146 4-fold oligomerization interface [polypeptide binding]; other site 531844002147 metal binding residues [ion binding]; metal-binding site 531844002148 3-fold/trimer interface [polypeptide binding]; other site 531844002149 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 531844002150 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 531844002151 putative active site [active] 531844002152 oxyanion strand; other site 531844002153 catalytic triad [active] 531844002154 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 531844002155 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 531844002156 catalytic residues [active] 531844002157 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 531844002158 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 531844002159 substrate binding site [chemical binding]; other site 531844002160 glutamase interaction surface [polypeptide binding]; other site 531844002161 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 531844002162 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 531844002163 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 531844002164 metal binding site [ion binding]; metal-binding site 531844002165 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 531844002166 Peptidase family M28; Region: Peptidase_M28; pfam04389 531844002167 metal binding site [ion binding]; metal-binding site 531844002168 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002169 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 531844002170 23S rRNA binding site [nucleotide binding]; other site 531844002171 L21 binding site [polypeptide binding]; other site 531844002172 L13 binding site [polypeptide binding]; other site 531844002173 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 531844002174 P63C domain; Region: P63C; pfam10546 531844002175 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 531844002176 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 531844002177 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 531844002178 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 531844002179 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 531844002180 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 531844002181 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 531844002182 active site 531844002183 dimer interface [polypeptide binding]; other site 531844002184 motif 1; other site 531844002185 motif 2; other site 531844002186 motif 3; other site 531844002187 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 531844002188 anticodon binding site; other site 531844002189 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 531844002190 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 531844002191 catalytic residues [active] 531844002192 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 531844002193 metal binding site [ion binding]; metal-binding site 531844002194 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 531844002195 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 531844002196 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844002197 Interdomain contacts; other site 531844002198 Cytokine receptor motif; other site 531844002199 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 531844002201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 531844002202 active site 531844002203 Endonuclease I; Region: Endonuclease_1; pfam04231 531844002204 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844002205 Interdomain contacts; other site 531844002206 Cytokine receptor motif; other site 531844002207 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002208 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 531844002209 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 531844002210 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 531844002211 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 531844002212 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 531844002213 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 531844002214 DNA binding residues [nucleotide binding] 531844002215 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 531844002216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 531844002217 ATP binding site [chemical binding]; other site 531844002218 putative Mg++ binding site [ion binding]; other site 531844002219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844002220 nucleotide binding region [chemical binding]; other site 531844002221 ATP-binding site [chemical binding]; other site 531844002222 DbpA RNA binding domain; Region: DbpA; pfam03880 531844002223 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 531844002224 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 531844002225 RNA binding site [nucleotide binding]; other site 531844002226 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 531844002227 RNA binding site [nucleotide binding]; other site 531844002228 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 531844002229 RNA binding site [nucleotide binding]; other site 531844002230 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 531844002231 RNA binding site [nucleotide binding]; other site 531844002232 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 531844002233 RNA binding site [nucleotide binding]; other site 531844002234 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 531844002235 RNA binding site [nucleotide binding]; other site 531844002236 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 531844002237 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 531844002238 PA/protease or protease-like domain interface [polypeptide binding]; other site 531844002239 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 531844002240 Zn binding site [ion binding]; other site 531844002241 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002242 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002243 C2 domain; Region: C2; cl14603 531844002244 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 531844002245 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 531844002246 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 531844002247 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 531844002248 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 531844002249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844002250 Walker A/P-loop; other site 531844002251 ATP binding site [chemical binding]; other site 531844002252 Q-loop/lid; other site 531844002253 ABC transporter signature motif; other site 531844002254 Walker B; other site 531844002255 D-loop; other site 531844002256 H-loop/switch region; other site 531844002257 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 531844002258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 531844002259 argininosuccinate synthase; Provisional; Region: PRK13820 531844002260 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 531844002261 Ligand Binding Site [chemical binding]; other site 531844002262 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 531844002263 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 531844002264 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 531844002265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 531844002266 inhibitor-cofactor binding pocket; inhibition site 531844002267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002268 catalytic residue [active] 531844002269 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 531844002270 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 531844002271 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 531844002272 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 531844002273 nucleotide binding site [chemical binding]; other site 531844002274 N-acetyl-L-glutamate binding site [chemical binding]; other site 531844002275 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 531844002276 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 531844002277 metal binding site [ion binding]; metal-binding site 531844002278 dimer interface [polypeptide binding]; other site 531844002279 argininosuccinate lyase; Provisional; Region: PRK00855 531844002280 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 531844002281 active sites [active] 531844002282 tetramer interface [polypeptide binding]; other site 531844002283 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 531844002284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 531844002285 putative DNA binding site [nucleotide binding]; other site 531844002286 dimerization interface [polypeptide binding]; other site 531844002287 putative Zn2+ binding site [ion binding]; other site 531844002288 AsnC family; Region: AsnC_trans_reg; pfam01037 531844002289 Cupin domain; Region: Cupin_2; pfam07883 531844002290 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 531844002291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844002292 motif II; other site 531844002293 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 531844002294 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 531844002295 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 531844002296 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 531844002297 DNA polymerase III, delta subunit; Region: holA; TIGR01128 531844002298 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 531844002299 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 531844002300 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 531844002301 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 531844002302 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 531844002303 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 531844002304 active site 531844002305 DNA binding site [nucleotide binding] 531844002306 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 531844002307 DNA binding site [nucleotide binding] 531844002308 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 531844002309 nucleotide binding site [chemical binding]; other site 531844002310 Predicted membrane protein [Function unknown]; Region: COG2323 531844002311 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002312 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 531844002313 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 531844002314 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 531844002315 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 531844002316 RNA binding site [nucleotide binding]; other site 531844002317 Histidine kinase; Region: HisKA_3; pfam07730 531844002318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844002319 ATP binding site [chemical binding]; other site 531844002320 Mg2+ binding site [ion binding]; other site 531844002321 G-X-G motif; other site 531844002322 META domain; Region: META; pfam03724 531844002323 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 531844002324 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 531844002325 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002326 Domain of unknown function (DUF389); Region: DUF389; cl00781 531844002327 methionine aminotransferase; Validated; Region: PRK09082 531844002328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 531844002329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002330 homodimer interface [polypeptide binding]; other site 531844002331 catalytic residue [active] 531844002332 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 531844002333 Peptidase family M28; Region: Peptidase_M28; pfam04389 531844002334 metal binding site [ion binding]; metal-binding site 531844002335 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 531844002336 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 531844002337 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 531844002338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844002339 Walker A/P-loop; other site 531844002340 ATP binding site [chemical binding]; other site 531844002341 Q-loop/lid; other site 531844002342 ABC transporter signature motif; other site 531844002343 Walker B; other site 531844002344 D-loop; other site 531844002345 H-loop/switch region; other site 531844002346 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 531844002347 DNA polymerase III subunit beta; Validated; Region: PRK05643 531844002348 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 531844002349 putative DNA binding surface [nucleotide binding]; other site 531844002350 dimer interface [polypeptide binding]; other site 531844002351 beta-clamp/clamp loader binding surface; other site 531844002352 beta-clamp/translesion DNA polymerase binding surface; other site 531844002353 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 531844002354 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 531844002355 putative tRNA-binding site [nucleotide binding]; other site 531844002356 B3/4 domain; Region: B3_4; pfam03483 531844002357 tRNA synthetase B5 domain; Region: B5; smart00874 531844002358 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 531844002359 dimer interface [polypeptide binding]; other site 531844002360 motif 1; other site 531844002361 motif 3; other site 531844002362 motif 2; other site 531844002363 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 531844002364 META domain; Region: META; pfam03724 531844002365 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 531844002366 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 531844002367 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 531844002368 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 531844002369 Peptidase family M23; Region: Peptidase_M23; pfam01551 531844002370 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 531844002371 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 531844002372 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 531844002373 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 531844002374 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 531844002375 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 531844002376 ribonuclease Z; Reviewed; Region: PRK00055 531844002377 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 531844002378 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 531844002379 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 531844002380 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 531844002381 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 531844002382 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 531844002383 FtsX-like permease family; Region: FtsX; pfam02687 531844002384 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 531844002385 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 531844002386 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 531844002387 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 531844002388 RNA binding site [nucleotide binding]; other site 531844002389 active site 531844002390 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 531844002391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 531844002392 RNA binding surface [nucleotide binding]; other site 531844002393 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 531844002394 probable active site [active] 531844002395 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 531844002396 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 531844002397 TrkA-C domain; Region: TrkA_C; pfam02080 531844002398 TrkA-C domain; Region: TrkA_C; pfam02080 531844002399 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 531844002400 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 531844002401 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 531844002402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 531844002403 active site 531844002404 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 531844002405 four helix bundle protein; Region: TIGR02436 531844002406 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 531844002407 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 531844002408 dimer interface [polypeptide binding]; other site 531844002409 active site 531844002410 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 531844002411 four helix bundle protein; Region: TIGR02436 531844002412 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 531844002413 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 531844002414 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 531844002415 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 531844002416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 531844002417 substrate binding site [chemical binding]; other site 531844002418 oxyanion hole (OAH) forming residues; other site 531844002419 trimer interface [polypeptide binding]; other site 531844002420 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 531844002421 MarR family; Region: MarR; pfam01047 531844002422 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 531844002423 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 531844002424 Walker A/P-loop; other site 531844002425 ATP binding site [chemical binding]; other site 531844002426 Q-loop/lid; other site 531844002427 ABC transporter signature motif; other site 531844002428 Walker B; other site 531844002429 D-loop; other site 531844002430 H-loop/switch region; other site 531844002431 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 531844002432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 531844002433 ABC-ATPase subunit interface; other site 531844002434 dimer interface [polypeptide binding]; other site 531844002435 putative PBP binding regions; other site 531844002436 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 531844002437 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 531844002438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 531844002439 catalytic residues [active] 531844002440 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 531844002441 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 531844002442 FAD binding pocket [chemical binding]; other site 531844002443 FAD binding motif [chemical binding]; other site 531844002444 phosphate binding motif [ion binding]; other site 531844002445 beta-alpha-beta structure motif; other site 531844002446 NAD(p) ribose binding residues [chemical binding]; other site 531844002447 NAD binding pocket [chemical binding]; other site 531844002448 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 531844002449 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 531844002450 catalytic loop [active] 531844002451 iron binding site [ion binding]; other site 531844002452 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 531844002453 putative active site [active] 531844002454 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 531844002455 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 531844002456 ATP-binding site [chemical binding]; other site 531844002457 Sugar specificity; other site 531844002458 Pyrimidine base specificity; other site 531844002459 Septum formation initiator; Region: DivIC; cl17659 531844002460 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 531844002461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844002462 S-adenosylmethionine binding site [chemical binding]; other site 531844002463 hypothetical protein; Validated; Region: PRK09104 531844002464 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 531844002465 metal binding site [ion binding]; metal-binding site 531844002466 putative dimer interface [polypeptide binding]; other site 531844002467 short chain dehydrogenase; Provisional; Region: PRK07326 531844002468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844002469 NAD(P) binding site [chemical binding]; other site 531844002470 active site 531844002471 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 531844002472 Ligand binding site [chemical binding]; other site 531844002473 Electron transfer flavoprotein domain; Region: ETF; pfam01012 531844002474 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 531844002475 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 531844002476 Ligand binding site [chemical binding]; other site 531844002477 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 531844002478 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 531844002479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 531844002480 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 531844002481 Bifunctional nuclease; Region: DNase-RNase; pfam02577 531844002482 nucleoside transporter; Region: 2A0110; TIGR00889 531844002483 acetyl-CoA C-acetyltransferase; Region: PLN02644 531844002484 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 531844002485 dimer interface [polypeptide binding]; other site 531844002486 active site 531844002487 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 531844002488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844002489 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 531844002490 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 531844002491 UbiA prenyltransferase family; Region: UbiA; pfam01040 531844002492 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 531844002493 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 531844002494 RNA binding surface [nucleotide binding]; other site 531844002495 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 531844002496 active site 531844002497 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 531844002498 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844002499 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002500 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 531844002501 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 531844002502 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 531844002503 dimer interface [polypeptide binding]; other site 531844002504 catalytic triad [active] 531844002505 peroxidatic and resolving cysteines [active] 531844002506 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844002507 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844002508 ligand binding site [chemical binding]; other site 531844002509 flexible hinge region; other site 531844002510 DinB superfamily; Region: DinB_2; pfam12867 531844002511 SnoaL-like domain; Region: SnoaL_2; pfam12680 531844002512 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 531844002513 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 531844002514 dimer interface [polypeptide binding]; other site 531844002515 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 531844002516 putative hydrophobic ligand binding site [chemical binding]; other site 531844002517 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 531844002518 dimer interface [polypeptide binding]; other site 531844002519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 531844002520 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 531844002521 dimer interface [polypeptide binding]; other site 531844002522 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 531844002523 hydrophobic ligand binding site; other site 531844002524 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 531844002525 putative hydrophobic ligand binding site [chemical binding]; other site 531844002526 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 531844002527 HSP70 interaction site [polypeptide binding]; other site 531844002528 glycine dehydrogenase; Provisional; Region: PRK05367 531844002529 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 531844002530 tetramer interface [polypeptide binding]; other site 531844002531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002532 catalytic residue [active] 531844002533 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 531844002534 tetramer interface [polypeptide binding]; other site 531844002535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002536 catalytic residue [active] 531844002537 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 531844002538 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002539 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 531844002540 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974 531844002541 putative DNA binding site [nucleotide binding]; other site 531844002542 catalytic residue [active] 531844002543 putative H2TH interface [polypeptide binding]; other site 531844002544 putative catalytic residues [active] 531844002545 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 531844002546 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 531844002547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 531844002548 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 531844002549 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 531844002550 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 531844002551 active site 531844002552 catalytic residues [active] 531844002553 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 531844002554 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 531844002555 amino acid transporter; Region: 2A0306; TIGR00909 531844002556 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 531844002557 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 531844002558 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 531844002559 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 531844002560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844002561 binding surface 531844002562 TPR motif; other site 531844002563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844002564 binding surface 531844002565 TPR motif; other site 531844002566 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844002567 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 531844002568 Transcriptional regulators [Transcription]; Region: MarR; COG1846 531844002569 MarR family; Region: MarR; pfam01047 531844002570 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 531844002571 dimer interface [polypeptide binding]; other site 531844002572 FMN binding site [chemical binding]; other site 531844002573 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 531844002574 active site 531844002575 intersubunit interactions; other site 531844002576 catalytic residue [active] 531844002577 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 531844002578 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 531844002579 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002580 acetyl-CoA synthetase; Provisional; Region: PRK00174 531844002581 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 531844002582 active site 531844002583 CoA binding site [chemical binding]; other site 531844002584 acyl-activating enzyme (AAE) consensus motif; other site 531844002585 AMP binding site [chemical binding]; other site 531844002586 acetate binding site [chemical binding]; other site 531844002587 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 531844002588 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 531844002589 acyl-activating enzyme (AAE) consensus motif; other site 531844002590 putative AMP binding site [chemical binding]; other site 531844002591 putative active site [active] 531844002592 putative CoA binding site [chemical binding]; other site 531844002593 Response regulator receiver domain; Region: Response_reg; pfam00072 531844002594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844002595 active site 531844002596 phosphorylation site [posttranslational modification] 531844002597 intermolecular recognition site; other site 531844002598 dimerization interface [polypeptide binding]; other site 531844002599 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 531844002600 Na binding site [ion binding]; other site 531844002601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844002602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844002603 dimer interface [polypeptide binding]; other site 531844002604 phosphorylation site [posttranslational modification] 531844002605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844002606 ATP binding site [chemical binding]; other site 531844002607 Mg2+ binding site [ion binding]; other site 531844002608 G-X-G motif; other site 531844002609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844002610 putative substrate translocation pore; other site 531844002611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 531844002612 Homeodomain-like domain; Region: HTH_23; pfam13384 531844002613 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 531844002614 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 531844002615 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 531844002616 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 531844002617 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 531844002618 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 531844002619 catalytic site [active] 531844002620 subunit interface [polypeptide binding]; other site 531844002621 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 531844002622 four helix bundle protein; Region: TIGR02436 531844002623 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 531844002624 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 531844002625 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 531844002626 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 531844002627 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 531844002628 ATP-grasp domain; Region: ATP-grasp_4; cl17255 531844002629 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 531844002630 IMP binding site; other site 531844002631 dimer interface [polypeptide binding]; other site 531844002632 interdomain contacts; other site 531844002633 partial ornithine binding site; other site 531844002634 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844002635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 531844002636 Transposase; Region: DEDD_Tnp_IS110; pfam01548 531844002637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 531844002638 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 531844002639 AAA domain; Region: AAA_21; pfam13304 531844002640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 531844002641 ATP binding site [chemical binding]; other site 531844002642 Q-loop/lid; other site 531844002643 ABC transporter signature motif; other site 531844002644 Walker B; other site 531844002645 D-loop; other site 531844002646 H-loop/switch region; other site 531844002647 Predicted helicase [General function prediction only]; Region: COG4889 531844002648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844002649 non-specific DNA binding site [nucleotide binding]; other site 531844002650 salt bridge; other site 531844002651 sequence-specific DNA binding site [nucleotide binding]; other site 531844002652 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844002653 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844002654 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844002655 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844002656 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844002657 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002658 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 531844002659 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 531844002660 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 531844002661 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 531844002662 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 531844002663 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 531844002664 DNA binding site [nucleotide binding] 531844002665 active site 531844002666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 531844002667 aldehyde dehydrogenase family 7 member; Region: PLN02315 531844002668 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 531844002669 tetrameric interface [polypeptide binding]; other site 531844002670 NAD binding site [chemical binding]; other site 531844002671 catalytic residues [active] 531844002672 L-lysine aminotransferase; Provisional; Region: PRK08297 531844002673 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 531844002674 inhibitor-cofactor binding pocket; inhibition site 531844002675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844002676 catalytic residue [active] 531844002677 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 531844002678 Tetratricopeptide repeat; Region: TPR_16; pfam13432 531844002679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844002680 TPR motif; other site 531844002681 binding surface 531844002682 Helix-turn-helix domain; Region: HTH_18; pfam12833 531844002683 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 531844002684 tetramer interface [polypeptide binding]; other site 531844002685 TPP-binding site [chemical binding]; other site 531844002686 heterodimer interface [polypeptide binding]; other site 531844002687 phosphorylation loop region [posttranslational modification] 531844002688 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 531844002689 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 531844002690 PYR/PP interface [polypeptide binding]; other site 531844002691 dimer interface [polypeptide binding]; other site 531844002692 TPP binding site [chemical binding]; other site 531844002693 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 531844002694 Domain of unknown function (DUF305); Region: DUF305; pfam03713 531844002695 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 531844002696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 531844002697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 531844002698 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 531844002699 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 531844002700 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 531844002701 Predicted esterase [General function prediction only]; Region: COG0400 531844002702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844002703 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 531844002704 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 531844002705 Uncharacterized conserved protein [Function unknown]; Region: COG4198 531844002706 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 531844002707 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 531844002708 NAD binding site [chemical binding]; other site 531844002709 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 531844002710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 531844002711 catalytic residue [active] 531844002712 4Fe-4S binding domain; Region: Fer4; cl02805 531844002713 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 531844002714 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 531844002715 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 531844002716 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 531844002717 [2Fe-2S] cluster binding site [ion binding]; other site 531844002718 Competence-damaged protein; Region: CinA; pfam02464 531844002719 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 531844002720 NAD(P) binding site [chemical binding]; other site 531844002721 catalytic residues [active] 531844002722 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 531844002723 DNA gyrase subunit A; Validated; Region: PRK05560 531844002724 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 531844002725 CAP-like domain; other site 531844002726 active site 531844002727 primary dimer interface [polypeptide binding]; other site 531844002728 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 531844002729 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 531844002730 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 531844002731 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 531844002732 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 531844002733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 531844002734 TPR repeat; Region: TPR_11; pfam13414 531844002735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844002736 TPR motif; other site 531844002737 binding surface 531844002738 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 531844002739 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 531844002740 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 531844002741 active site 531844002742 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 531844002743 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 531844002744 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 531844002745 metal binding site [ion binding]; metal-binding site 531844002746 putative dimer interface [polypeptide binding]; other site 531844002747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844002748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 531844002749 putative substrate translocation pore; other site 531844002750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844002751 putative substrate translocation pore; other site 531844002752 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 531844002753 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 531844002754 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 531844002755 trmE is a tRNA modification GTPase; Region: trmE; cd04164 531844002756 G1 box; other site 531844002757 GTP/Mg2+ binding site [chemical binding]; other site 531844002758 Switch I region; other site 531844002759 G2 box; other site 531844002760 Switch II region; other site 531844002761 G3 box; other site 531844002762 G4 box; other site 531844002763 G5 box; other site 531844002764 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 531844002765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844002766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844002767 ligand binding site [chemical binding]; other site 531844002768 flexible hinge region; other site 531844002769 Domain of unknown function (DUF336); Region: DUF336; cl01249 531844002770 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 531844002771 active site 531844002772 homotetramer interface [polypeptide binding]; other site 531844002773 META domain; Region: META; pfam03724 531844002774 META domain; Region: META; pfam03724 531844002775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844002776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844002777 ligand binding site [chemical binding]; other site 531844002778 flexible hinge region; other site 531844002779 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 531844002780 short chain dehydrogenase; Provisional; Region: PRK07774 531844002781 NADP binding site [chemical binding]; other site 531844002782 substrate binding site [chemical binding]; other site 531844002783 active site 531844002784 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 531844002785 N-terminal plug; other site 531844002786 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 531844002787 ligand-binding site [chemical binding]; other site 531844002788 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 531844002789 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 531844002790 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 531844002791 DoxX-like family; Region: DoxX_2; pfam13564 531844002792 Predicted transcriptional regulators [Transcription]; Region: COG1733 531844002793 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 531844002794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 531844002795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 531844002796 short chain dehydrogenase; Provisional; Region: PRK06180 531844002797 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 531844002798 NADP binding site [chemical binding]; other site 531844002799 active site 531844002800 steroid binding site; other site 531844002801 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 531844002802 dinuclear metal binding motif [ion binding]; other site 531844002803 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 531844002804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 531844002805 active site 531844002806 phosphorylation site [posttranslational modification] 531844002807 intermolecular recognition site; other site 531844002808 dimerization interface [polypeptide binding]; other site 531844002809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844002810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 531844002811 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 531844002812 ATP binding site [chemical binding]; other site 531844002813 Mg2+ binding site [ion binding]; other site 531844002814 G-X-G motif; other site 531844002815 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 531844002816 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 531844002817 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 531844002818 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 531844002819 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 531844002820 Staphylococcal nuclease homologues; Region: SNc; smart00318 531844002821 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 531844002822 Catalytic site; other site 531844002823 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 531844002824 Uncharacterized conserved protein [Function unknown]; Region: COG1479 531844002825 Protein of unknown function DUF262; Region: DUF262; pfam03235 531844002826 Protein of unknown function DUF262; Region: DUF262; pfam03235 531844002827 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 531844002828 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 531844002829 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 531844002830 active site 531844002831 Restriction endonuclease; Region: Mrr_cat; pfam04471 531844002832 AAA domain; Region: AAA_25; pfam13481 531844002833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844002834 AAA domain; Region: AAA_21; pfam13304 531844002835 Walker A/P-loop; other site 531844002836 ATP binding site [chemical binding]; other site 531844002837 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844002838 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844002839 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844002840 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 531844002841 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844002842 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 531844002843 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844002844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 531844002845 RteC protein; Region: RteC; pfam09357 531844002846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 531844002847 LytTr DNA-binding domain; Region: LytTR; smart00850 531844002848 Putative esterase; Region: Esterase; pfam00756 531844002849 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 531844002850 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 531844002851 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 531844002852 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 531844002853 Ca binding site [ion binding]; other site 531844002854 active site 531844002855 homodimer interface [polypeptide binding]; other site 531844002856 catalytic site [active] 531844002857 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 531844002858 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 531844002859 active site 531844002860 DNA binding site [nucleotide binding] 531844002861 Histidine kinase; Region: His_kinase; pfam06580 531844002862 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 531844002863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844002864 active site 531844002865 phosphorylation site [posttranslational modification] 531844002866 intermolecular recognition site; other site 531844002867 dimerization interface [polypeptide binding]; other site 531844002868 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 531844002869 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 531844002870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 531844002871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 531844002872 dimerization interface [polypeptide binding]; other site 531844002873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844002874 putative active site [active] 531844002875 heme pocket [chemical binding]; other site 531844002876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844002877 dimer interface [polypeptide binding]; other site 531844002878 phosphorylation site [posttranslational modification] 531844002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844002880 ATP binding site [chemical binding]; other site 531844002881 Mg2+ binding site [ion binding]; other site 531844002882 G-X-G motif; other site 531844002883 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 531844002884 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 531844002885 Ligand Binding Site [chemical binding]; other site 531844002886 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 531844002887 potassium-transporting ATPase subunit C; Provisional; Region: PRK14002 531844002888 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 531844002889 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 531844002890 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 531844002891 catalytic site [active] 531844002892 Soluble P-type ATPase [General function prediction only]; Region: COG4087 531844002893 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 531844002894 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 531844002895 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 531844002896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844002897 active site 531844002898 phosphorylation site [posttranslational modification] 531844002899 intermolecular recognition site; other site 531844002900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844002901 ATP binding site [chemical binding]; other site 531844002902 Walker B motif; other site 531844002903 arginine finger; other site 531844002904 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 531844002905 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 531844002906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 531844002907 Soluble P-type ATPase [General function prediction only]; Region: COG4087 531844002908 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844002909 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844002910 CARDB; Region: CARDB; pfam07705 531844002911 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002912 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844002913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844002914 binding surface 531844002915 TPR motif; other site 531844002916 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844002917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844002918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844002919 binding surface 531844002920 TPR motif; other site 531844002921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 531844002922 binding surface 531844002923 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844002924 TPR motif; other site 531844002925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 531844002926 Histidine kinase; Region: HisKA_3; pfam07730 531844002927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844002928 ATP binding site [chemical binding]; other site 531844002929 Mg2+ binding site [ion binding]; other site 531844002930 G-X-G motif; other site 531844002931 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 531844002932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844002933 active site 531844002934 phosphorylation site [posttranslational modification] 531844002935 intermolecular recognition site; other site 531844002936 dimerization interface [polypeptide binding]; other site 531844002937 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844002938 DNA binding residues [nucleotide binding] 531844002939 dimerization interface [polypeptide binding]; other site 531844002940 PQQ-like domain; Region: PQQ_2; pfam13360 531844002941 MepB protein; Region: MepB; cl01985 531844002942 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 531844002943 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 531844002944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844002945 non-specific DNA binding site [nucleotide binding]; other site 531844002946 salt bridge; other site 531844002947 sequence-specific DNA binding site [nucleotide binding]; other site 531844002948 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 531844002949 Catalytic site [active] 531844002950 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 531844002951 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 531844002952 active site 531844002953 DNA binding site [nucleotide binding] 531844002954 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 531844002955 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 531844002956 active site 531844002957 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 531844002958 PHP Thumb interface [polypeptide binding]; other site 531844002959 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 531844002960 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 531844002961 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 531844002962 Helix-turn-helix domain; Region: HTH_18; pfam12833 531844002963 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 531844002964 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 531844002965 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 531844002966 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 531844002967 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 531844002968 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 531844002969 tRNA-specific 2-thiouridylase MnmA; Reviewed; Region: mnmA; PRK00143 531844002970 Endonuclease I; Region: Endonuclease_1; cl01003 531844002971 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844002972 Interdomain contacts; other site 531844002973 Cytokine receptor motif; other site 531844002974 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844002975 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 531844002976 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 531844002977 Bacterial SH3 domain; Region: SH3_3; cl17532 531844002978 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 531844002979 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 531844002980 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 531844002981 YcxB-like protein; Region: YcxB; pfam14317 531844002982 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 531844002983 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 531844002984 active site 531844002985 DNA binding site [nucleotide binding] 531844002986 Int/Topo IB signature motif; other site 531844002987 catalytic residues [active] 531844002988 short chain dehydrogenase; Provisional; Region: PRK06701 531844002989 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 531844002990 NAD binding site [chemical binding]; other site 531844002991 metal binding site [ion binding]; metal-binding site 531844002992 active site 531844002993 potential frameshift: common BLAST hit: gi|110639218|ref|YP_679427.1| ATP-dependent DNA ligase 531844002994 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 531844002995 active site 531844002996 DNA binding site [nucleotide binding] 531844002997 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 531844002998 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 531844002999 DNA binding site [nucleotide binding] 531844003000 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 531844003001 nucleotide binding site [chemical binding]; other site 531844003002 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 531844003003 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 531844003004 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 531844003005 putative DNA binding site [nucleotide binding]; other site 531844003006 putative homodimer interface [polypeptide binding]; other site 531844003007 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 531844003008 putative catalytic site [active] 531844003009 putative phosphate binding site [ion binding]; other site 531844003010 active site 531844003011 metal binding site A [ion binding]; metal-binding site 531844003012 DNA binding site [nucleotide binding] 531844003013 putative AP binding site [nucleotide binding]; other site 531844003014 putative metal binding site B [ion binding]; other site 531844003015 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 531844003016 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 531844003017 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 531844003018 Peptidase family M28; Region: Peptidase_M28; pfam04389 531844003019 metal binding site [ion binding]; metal-binding site 531844003020 Membrane protein of unknown function; Region: DUF360; pfam04020 531844003021 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 531844003022 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844003023 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 531844003024 putative active site [active] 531844003025 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 531844003026 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 531844003027 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 531844003028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844003029 FeS/SAM binding site; other site 531844003030 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 531844003031 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 531844003032 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 531844003033 substrate binding pocket [chemical binding]; other site 531844003034 chain length determination region; other site 531844003035 substrate-Mg2+ binding site; other site 531844003036 catalytic residues [active] 531844003037 aspartate-rich region 1; other site 531844003038 active site lid residues [active] 531844003039 aspartate-rich region 2; other site 531844003040 Protein of unknown function DUF72; Region: DUF72; pfam01904 531844003041 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 531844003042 intracellular protease, PfpI family; Region: PfpI; TIGR01382 531844003043 proposed catalytic triad [active] 531844003044 conserved cys residue [active] 531844003045 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 531844003046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 531844003047 Soluble P-type ATPase [General function prediction only]; Region: COG4087 531844003048 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 531844003049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 531844003050 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 531844003051 hypothetical protein; Validated; Region: PRK02101 531844003052 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 531844003053 four helix bundle protein; Region: TIGR02436 531844003054 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 531844003055 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 531844003056 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 531844003057 classical (c) SDRs; Region: SDR_c; cd05233 531844003058 NAD(P) binding site [chemical binding]; other site 531844003059 active site 531844003060 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 531844003061 Peptidase family M23; Region: Peptidase_M23; pfam01551 531844003062 Bacterial SH3 domain; Region: SH3_3; pfam08239 531844003063 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844003064 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 531844003065 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 531844003066 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 531844003067 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 531844003068 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844003069 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844003070 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 531844003071 RibD C-terminal domain; Region: RibD_C; cl17279 531844003072 Helix-turn-helix domain; Region: HTH_18; pfam12833 531844003073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 531844003074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 531844003075 active site 531844003076 DNA binding site [nucleotide binding] 531844003077 Int/Topo IB signature motif; other site 531844003078 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 531844003079 Putative transposase; Region: Y2_Tnp; pfam04986 531844003080 Transposase domain (DUF772); Region: DUF772; pfam05598 531844003081 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 531844003082 active site 531844003083 DNA binding site [nucleotide binding] 531844003084 Int/Topo IB signature motif; other site 531844003085 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 531844003086 Putative transposase; Region: Y2_Tnp; pfam04986 531844003087 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 531844003088 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 531844003089 Active Sites [active] 531844003090 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 531844003091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844003092 Walker A/P-loop; other site 531844003093 ATP binding site [chemical binding]; other site 531844003094 DNA-sulfur modification-associated; Region: DndB; pfam14072 531844003095 Protein of unknown function (DUF511); Region: DUF511; cl01114 531844003096 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 531844003097 AAA-like domain; Region: AAA_10; pfam12846 531844003098 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 531844003099 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 531844003100 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844003101 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844003102 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844003103 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844003104 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 531844003105 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844003106 Methylamine utilisation protein MauE; Region: MauE; pfam07291 531844003107 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 531844003108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 531844003109 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 531844003110 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 531844003111 hypothetical protein; Provisional; Region: PRK10621 531844003112 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 531844003113 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_9; cd12170 531844003114 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 531844003115 putative ligand binding site [chemical binding]; other site 531844003116 putative NAD binding site [chemical binding]; other site 531844003117 Predicted dinucleotide-utilizing enzyme [General function prediction only]; Region: COG1712 531844003118 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 531844003119 Domain of unknown function DUF108; Region: DUF108; pfam01958 531844003120 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 531844003121 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844003123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844003124 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 531844003125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 531844003126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 531844003127 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 531844003128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 531844003129 Ligand Binding Site [chemical binding]; other site 531844003130 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 531844003131 Ligand Binding Site [chemical binding]; other site 531844003132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 531844003133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 531844003134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 531844003135 Coenzyme A binding pocket [chemical binding]; other site 531844003136 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 531844003137 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 531844003138 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 531844003139 catalytic residue [active] 531844003140 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 531844003141 Helix-turn-helix domain; Region: HTH_18; pfam12833 531844003142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 531844003143 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003144 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 531844003145 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 531844003146 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 531844003147 G1 box; other site 531844003148 putative GEF interaction site [polypeptide binding]; other site 531844003149 GTP/Mg2+ binding site [chemical binding]; other site 531844003150 Switch I region; other site 531844003151 G2 box; other site 531844003152 G3 box; other site 531844003153 Switch II region; other site 531844003154 G4 box; other site 531844003155 G5 box; other site 531844003156 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 531844003157 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 531844003158 Protein of unknown function (DUF465); Region: DUF465; cl01070 531844003159 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 531844003160 Penicillinase repressor; Region: Pencillinase_R; pfam03965 531844003161 GTP-binding protein YchF; Reviewed; Region: PRK09601 531844003162 YchF GTPase; Region: YchF; cd01900 531844003163 G1 box; other site 531844003164 GTP/Mg2+ binding site [chemical binding]; other site 531844003165 Switch I region; other site 531844003166 G2 box; other site 531844003167 Switch II region; other site 531844003168 G3 box; other site 531844003169 G4 box; other site 531844003170 G5 box; other site 531844003171 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 531844003172 Predicted flavoprotein [General function prediction only]; Region: COG0431 531844003173 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 531844003174 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 531844003175 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 531844003176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 531844003177 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 531844003178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844003179 motif II; other site 531844003180 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 531844003181 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 531844003182 Uncharacterized conserved protein [Function unknown]; Region: COG2013 531844003183 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 531844003184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844003185 ATP binding site [chemical binding]; other site 531844003186 Mg2+ binding site [ion binding]; other site 531844003187 G-X-G motif; other site 531844003188 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 531844003189 ATP binding site [chemical binding]; other site 531844003190 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 531844003191 active site 531844003192 putative metal-binding site [ion binding]; other site 531844003193 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 531844003194 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 531844003195 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 531844003196 CAP-like domain; other site 531844003197 active site 531844003198 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 531844003199 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 531844003200 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 531844003201 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 531844003202 Peptidase family M28; Region: Peptidase_M28; pfam04389 531844003203 metal binding site [ion binding]; metal-binding site 531844003204 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 531844003205 Surface antigen; Region: Bac_surface_Ag; pfam01103 531844003206 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 531844003207 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 531844003208 YtxH-like protein; Region: YtxH; pfam12732 531844003209 cytidylate kinase; Provisional; Region: cmk; PRK00023 531844003210 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 531844003211 CMP-binding site; other site 531844003212 The sites determining sugar specificity; other site 531844003213 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 531844003214 putative nucleotide binding site [chemical binding]; other site 531844003215 uridine monophosphate binding site [chemical binding]; other site 531844003216 homohexameric interface [polypeptide binding]; other site 531844003217 ribosome recycling factor; Reviewed; Region: frr; PRK00083 531844003218 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 531844003219 hinge region; other site 531844003220 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 531844003221 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003222 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 531844003223 NADH(P)-binding; Region: NAD_binding_10; pfam13460 531844003224 NAD binding site [chemical binding]; other site 531844003225 active site 531844003226 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844003227 Protein of unknown function (DUF419); Region: DUF419; pfam04237 531844003228 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 531844003229 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 531844003230 active site 531844003231 Riboflavin kinase; Region: Flavokinase; pfam01687 531844003232 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 531844003233 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 531844003234 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 531844003235 alpha subunit interaction interface [polypeptide binding]; other site 531844003236 Walker A motif; other site 531844003237 ATP binding site [chemical binding]; other site 531844003238 Walker B motif; other site 531844003239 inhibitor binding site; inhibition site 531844003240 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 531844003241 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 531844003242 gamma subunit interface [polypeptide binding]; other site 531844003243 LBP interface [polypeptide binding]; other site 531844003244 B12 binding domain; Region: B12-binding; pfam02310 531844003245 B12 binding site [chemical binding]; other site 531844003246 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 531844003247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 531844003248 EamA-like transporter family; Region: EamA; pfam00892 531844003249 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 531844003250 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 531844003251 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 531844003252 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 531844003253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 531844003254 catalytic residue [active] 531844003255 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 531844003256 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 531844003257 dimer interface [polypeptide binding]; other site 531844003258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844003259 catalytic residue [active] 531844003260 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 531844003261 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 531844003262 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 531844003263 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 531844003264 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844003265 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844003266 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844003267 Predicted amidohydrolase [General function prediction only]; Region: COG0388 531844003268 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 531844003269 putative active site [active] 531844003270 catalytic triad [active] 531844003271 putative dimer interface [polypeptide binding]; other site 531844003272 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 531844003273 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 531844003274 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 531844003275 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 531844003276 DNA polymerase III subunit delta'; Validated; Region: PRK08485 531844003277 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 531844003278 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 531844003279 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 531844003280 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; pfam10614 531844003281 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 531844003282 Curli assembly protein CsgE; Region: CsgE; cl08115 531844003283 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 531844003284 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 531844003285 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 531844003286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 531844003287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 531844003288 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 531844003289 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 531844003290 HlyD family secretion protein; Region: HlyD_3; pfam13437 531844003291 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 531844003292 multidrug efflux protein; Reviewed; Region: PRK01766 531844003293 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 531844003294 cation binding site [ion binding]; other site 531844003295 Response regulator receiver domain; Region: Response_reg; pfam00072 531844003296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844003297 active site 531844003298 phosphorylation site [posttranslational modification] 531844003299 intermolecular recognition site; other site 531844003300 dimerization interface [polypeptide binding]; other site 531844003301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844003302 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 531844003303 Walker A motif; other site 531844003304 ATP binding site [chemical binding]; other site 531844003305 Walker B motif; other site 531844003306 arginine finger; other site 531844003307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 531844003308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 531844003309 catalytic residue [active] 531844003310 Histidine kinase; Region: HisKA_3; pfam07730 531844003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844003312 ATP binding site [chemical binding]; other site 531844003313 Mg2+ binding site [ion binding]; other site 531844003314 G-X-G motif; other site 531844003315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 531844003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844003317 active site 531844003318 phosphorylation site [posttranslational modification] 531844003319 intermolecular recognition site; other site 531844003320 dimerization interface [polypeptide binding]; other site 531844003321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844003322 DNA binding residues [nucleotide binding] 531844003323 dimerization interface [polypeptide binding]; other site 531844003324 NAD-dependent deacetylase; Provisional; Region: PRK00481 531844003325 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 531844003326 NAD+ binding site [chemical binding]; other site 531844003327 substrate binding site [chemical binding]; other site 531844003328 Zn binding site [ion binding]; other site 531844003329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 531844003330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 531844003331 Coenzyme A binding pocket [chemical binding]; other site 531844003332 phosphoglyceromutase; Provisional; Region: PRK05434 531844003333 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 531844003334 TPR repeat; Region: TPR_11; pfam13414 531844003335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844003336 binding surface 531844003337 TPR motif; other site 531844003338 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844003339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844003340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844003341 binding surface 531844003342 TPR motif; other site 531844003343 Tetratricopeptide repeat; Region: TPR_12; pfam13424 531844003344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 531844003345 Histidine kinase; Region: HisKA_3; pfam07730 531844003346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844003347 ATP binding site [chemical binding]; other site 531844003348 Mg2+ binding site [ion binding]; other site 531844003349 G-X-G motif; other site 531844003350 two component system sensor kinase SsrB; Provisional; Region: PRK15369 531844003351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844003352 active site 531844003353 phosphorylation site [posttranslational modification] 531844003354 intermolecular recognition site; other site 531844003355 dimerization interface [polypeptide binding]; other site 531844003356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844003357 DNA binding residues [nucleotide binding] 531844003358 dimerization interface [polypeptide binding]; other site 531844003359 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844003360 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 531844003361 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003362 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 531844003363 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 531844003364 homodimer interface [polypeptide binding]; other site 531844003365 putative substrate binding pocket [chemical binding]; other site 531844003366 diiron center [ion binding]; other site 531844003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844003368 active site 531844003369 motif I; other site 531844003370 motif II; other site 531844003371 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 531844003372 active site 531844003373 Methyltransferase domain; Region: Methyltransf_23; pfam13489 531844003374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844003375 GTPase Era; Reviewed; Region: era; PRK00089 531844003376 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 531844003377 G1 box; other site 531844003378 GTP/Mg2+ binding site [chemical binding]; other site 531844003379 Switch I region; other site 531844003380 G2 box; other site 531844003381 Switch II region; other site 531844003382 G3 box; other site 531844003383 G4 box; other site 531844003384 G5 box; other site 531844003385 KH domain; Region: KH_2; pfam07650 531844003386 DoxX; Region: DoxX; pfam07681 531844003387 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 531844003388 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844003389 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 531844003390 nudix motif; other site 531844003391 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 531844003392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 531844003393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 531844003394 active site 531844003395 probable DNA repair protein; Region: TIGR03623 531844003396 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 531844003397 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 531844003398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844003399 S-adenosylmethionine binding site [chemical binding]; other site 531844003400 aspartate aminotransferase; Provisional; Region: PRK05764 531844003401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 531844003402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844003403 homodimer interface [polypeptide binding]; other site 531844003404 catalytic residue [active] 531844003405 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 531844003406 Gammaherpesvirus protein of unknown function (DUF848); Region: DUF848; cl17636 531844003407 Putative zinc ribbon domain; Region: DUF164; pfam02591 531844003408 Uncharacterized conserved protein [Function unknown]; Region: COG0327 531844003409 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 531844003410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 531844003411 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 531844003412 Ion transport protein; Region: Ion_trans; pfam00520 531844003413 Ion channel; Region: Ion_trans_2; pfam07885 531844003414 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 531844003415 Double zinc ribbon; Region: DZR; pfam12773 531844003416 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 531844003417 active site 531844003418 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 531844003419 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 531844003420 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 531844003421 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 531844003422 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 531844003423 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 531844003424 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 531844003425 homodimer interface [polypeptide binding]; other site 531844003426 substrate-cofactor binding pocket; other site 531844003427 catalytic residue [active] 531844003428 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 531844003429 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 531844003430 active site 531844003431 Zn binding site [ion binding]; other site 531844003432 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 531844003433 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 531844003434 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 531844003435 oligomer interface [polypeptide binding]; other site 531844003436 active site 531844003437 metal binding site [ion binding]; metal-binding site 531844003438 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 531844003439 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 531844003440 substrate binding site [chemical binding]; other site 531844003441 hexamer interface [polypeptide binding]; other site 531844003442 metal binding site [ion binding]; metal-binding site 531844003443 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 531844003444 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 531844003445 active site 531844003446 multimer interface [polypeptide binding]; other site 531844003447 GTPase RsgA; Reviewed; Region: PRK00098 531844003448 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 531844003449 RNA binding site [nucleotide binding]; other site 531844003450 homodimer interface [polypeptide binding]; other site 531844003451 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 531844003452 GTPase/Zn-binding domain interface [polypeptide binding]; other site 531844003453 GTP/Mg2+ binding site [chemical binding]; other site 531844003454 G4 box; other site 531844003455 G5 box; other site 531844003456 G1 box; other site 531844003457 Switch I region; other site 531844003458 G2 box; other site 531844003459 G3 box; other site 531844003460 Switch II region; other site 531844003461 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 531844003462 Chorismate mutase type II; Region: CM_2; smart00830 531844003463 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 531844003464 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 531844003465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844003466 Walker A motif; other site 531844003467 ATP binding site [chemical binding]; other site 531844003468 Walker B motif; other site 531844003469 DNA polymerase III subunit delta'; Validated; Region: PRK08485 531844003470 arginine finger; other site 531844003471 cyanophycin synthetase; Provisional; Region: PRK14016 531844003472 ATP-grasp domain; Region: ATP-grasp_4; cl17255 531844003473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844003474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844003475 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 531844003476 proposed catalytic triad [active] 531844003477 active site nucleophile [active] 531844003478 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 531844003479 catalytic nucleophile [active] 531844003480 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 531844003481 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 531844003482 dimer interface [polypeptide binding]; other site 531844003483 active site 531844003484 CoA binding pocket [chemical binding]; other site 531844003485 Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832 531844003486 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 531844003487 oligomer interface [polypeptide binding]; other site 531844003488 metal binding site [ion binding]; metal-binding site 531844003489 putative Cl binding site [ion binding]; other site 531844003490 basic sphincter; other site 531844003491 hydrophobic gate; other site 531844003492 periplasmic entrance; other site 531844003493 Caspase domain; Region: Peptidase_C14; pfam00656 531844003494 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 531844003495 active site 531844003496 catalytic residues [active] 531844003497 potential frameshift: common BLAST hit: gi|146301976|ref|YP_001196567.1| patatin 531844003498 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 531844003499 active site 531844003500 nucleophile elbow; other site 531844003501 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 531844003502 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 531844003503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 531844003504 active site 531844003505 dimerization interface [polypeptide binding]; other site 531844003506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844003507 DNA binding residues [nucleotide binding] 531844003508 dimerization interface [polypeptide binding]; other site 531844003509 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 531844003510 active site 531844003511 catalytic site [active] 531844003512 substrate binding site [chemical binding]; other site 531844003513 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 531844003514 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 531844003515 active site 531844003516 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 531844003517 generic binding surface I; other site 531844003518 generic binding surface II; other site 531844003519 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003520 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 531844003521 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 531844003522 tetramer interface [polypeptide binding]; other site 531844003523 TPP-binding site [chemical binding]; other site 531844003524 heterodimer interface [polypeptide binding]; other site 531844003525 phosphorylation loop region [posttranslational modification] 531844003526 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 531844003527 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 531844003528 alpha subunit interface [polypeptide binding]; other site 531844003529 TPP binding site [chemical binding]; other site 531844003530 heterodimer interface [polypeptide binding]; other site 531844003531 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 531844003532 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 531844003533 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 531844003534 nucleotide binding pocket [chemical binding]; other site 531844003535 K-X-D-G motif; other site 531844003536 catalytic site [active] 531844003537 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 531844003538 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 531844003539 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 531844003540 Dimer interface [polypeptide binding]; other site 531844003541 BRCT sequence motif; other site 531844003542 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 531844003543 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 531844003544 interface (dimer of trimers) [polypeptide binding]; other site 531844003545 Substrate-binding/catalytic site; other site 531844003546 Zn-binding sites [ion binding]; other site 531844003547 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 531844003548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 531844003549 Putative esterase; Region: Esterase; pfam00756 531844003550 ATP-grasp domain; Region: ATP-grasp_4; cl17255 531844003551 carboxylate-amine ligase; Provisional; Region: PRK13515 531844003552 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 531844003553 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 531844003554 conserved cys residue [active] 531844003555 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 531844003556 putative dimer interface [polypeptide binding]; other site 531844003557 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 531844003558 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 531844003559 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 531844003560 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 531844003561 ligand binding site [chemical binding]; other site 531844003562 inorganic pyrophosphatase; Provisional; Region: PRK00642 531844003563 dimer interface [polypeptide binding]; other site 531844003564 substrate binding site [chemical binding]; other site 531844003565 metal binding sites [ion binding]; metal-binding site 531844003566 Methyltransferase domain; Region: Methyltransf_23; pfam13489 531844003567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844003568 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 531844003569 putative active site [active] 531844003570 putative metal binding site [ion binding]; other site 531844003571 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 531844003572 hypothetical protein; Reviewed; Region: PRK00024 531844003573 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 531844003574 MPN+ (JAMM) motif; other site 531844003575 Zinc-binding site [ion binding]; other site 531844003576 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 531844003577 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 531844003578 Walker A/P-loop; other site 531844003579 ATP binding site [chemical binding]; other site 531844003580 Q-loop/lid; other site 531844003581 ABC transporter signature motif; other site 531844003582 Walker B; other site 531844003583 D-loop; other site 531844003584 H-loop/switch region; other site 531844003585 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 531844003586 E3 interaction surface; other site 531844003587 lipoyl attachment site [posttranslational modification]; other site 531844003588 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 531844003589 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 531844003590 E3 interaction surface; other site 531844003591 lipoyl attachment site [posttranslational modification]; other site 531844003592 e3 binding domain; Region: E3_binding; pfam02817 531844003593 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 531844003594 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 531844003595 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 531844003596 tetramer interface [polypeptide binding]; other site 531844003597 TPP-binding site [chemical binding]; other site 531844003598 heterodimer interface [polypeptide binding]; other site 531844003599 phosphorylation loop region [posttranslational modification] 531844003600 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 531844003601 active site 531844003602 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 531844003603 Penicillinase repressor; Region: Pencillinase_R; cl17580 531844003604 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 531844003605 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 531844003606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 531844003607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 531844003608 active site 531844003609 catalytic tetrad [active] 531844003610 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003611 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 531844003612 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 531844003613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844003614 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 531844003615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 531844003616 DNA binding residues [nucleotide binding] 531844003617 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844003618 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844003619 ligand binding site [chemical binding]; other site 531844003620 flexible hinge region; other site 531844003621 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 531844003622 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 531844003623 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 531844003624 metal-dependent hydrolase; Provisional; Region: PRK13291 531844003625 DinB superfamily; Region: DinB_2; pfam12867 531844003626 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 531844003627 Isochorismatase family; Region: Isochorismatase; pfam00857 531844003628 catalytic triad [active] 531844003629 metal binding site [ion binding]; metal-binding site 531844003630 conserved cis-peptide bond; other site 531844003631 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 531844003632 Active site serine [active] 531844003633 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844003634 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844003635 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844003636 Fasciclin domain; Region: Fasciclin; pfam02469 531844003637 Fasciclin domain; Region: Fasciclin; pfam02469 531844003638 Peptidase family M23; Region: Peptidase_M23; pfam01551 531844003639 urocanate hydratase; Provisional; Region: PRK05414 531844003640 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 531844003641 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 531844003642 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 531844003643 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 531844003644 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 531844003645 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 531844003646 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 531844003647 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 531844003648 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 531844003649 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 531844003650 catalytic residues [active] 531844003651 dimer interface [polypeptide binding]; other site 531844003652 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 531844003653 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 531844003654 Ligand binding site; other site 531844003655 oligomer interface; other site 531844003656 RES domain; Region: RES; pfam08808 531844003657 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 531844003658 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 531844003659 aspartate aminotransferase; Provisional; Region: PRK05764 531844003660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 531844003661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844003662 homodimer interface [polypeptide binding]; other site 531844003663 catalytic residue [active] 531844003664 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 531844003665 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 531844003666 active site 531844003667 substrate binding site [chemical binding]; other site 531844003668 metal binding site [ion binding]; metal-binding site 531844003669 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 531844003670 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 531844003671 Putative Catalytic site; other site 531844003672 DXD motif; other site 531844003673 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 531844003674 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 531844003675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 531844003676 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 531844003677 UbiA prenyltransferase family; Region: UbiA; pfam01040 531844003678 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 531844003679 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 531844003680 substrate binding site [chemical binding]; other site 531844003681 oxyanion hole (OAH) forming residues; other site 531844003682 trimer interface [polypeptide binding]; other site 531844003683 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 531844003684 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 531844003685 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 531844003686 putative active site [active] 531844003687 Zn binding site [ion binding]; other site 531844003688 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 531844003689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844003690 non-specific DNA binding site [nucleotide binding]; other site 531844003691 salt bridge; other site 531844003692 sequence-specific DNA binding site [nucleotide binding]; other site 531844003693 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 531844003694 Walker A motif; other site 531844003695 ATP binding site [chemical binding]; other site 531844003696 Walker B motif; other site 531844003697 arginine finger; other site 531844003698 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 531844003699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 531844003700 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844003701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844003702 putative substrate translocation pore; other site 531844003703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844003704 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 531844003705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844003706 putative substrate translocation pore; other site 531844003707 POT family; Region: PTR2; cl17359 531844003708 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 531844003709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844003710 putative substrate translocation pore; other site 531844003711 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 531844003712 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 531844003713 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 531844003714 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 531844003715 generic binding surface II; other site 531844003716 ssDNA binding site; other site 531844003717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844003718 ATP binding site [chemical binding]; other site 531844003719 putative Mg++ binding site [ion binding]; other site 531844003720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844003721 nucleotide binding region [chemical binding]; other site 531844003722 ATP-binding site [chemical binding]; other site 531844003723 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 531844003724 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 531844003725 dihydropteroate synthase; Region: DHPS; TIGR01496 531844003726 substrate binding pocket [chemical binding]; other site 531844003727 inhibitor binding site; inhibition site 531844003728 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 531844003729 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 531844003730 tellurium resistance terB-like protein; Region: terB_like; cl11965 531844003731 metal binding site [ion binding]; metal-binding site 531844003732 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 531844003733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844003734 triosephosphate isomerase; Provisional; Region: PRK14567 531844003735 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 531844003736 substrate binding site [chemical binding]; other site 531844003737 dimer interface [polypeptide binding]; other site 531844003738 catalytic triad [active] 531844003739 Clp protease; Region: CLP_protease; pfam00574 531844003740 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 531844003741 oligomer interface [polypeptide binding]; other site 531844003742 active site residues [active] 531844003743 DNA primase, catalytic core; Region: dnaG; TIGR01391 531844003744 CHC2 zinc finger; Region: zf-CHC2; pfam01807 531844003745 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 531844003746 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 531844003747 active site 531844003748 metal binding site [ion binding]; metal-binding site 531844003749 interdomain interaction site; other site 531844003750 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 531844003751 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 531844003752 catalytic nucleophile [active] 531844003753 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 531844003754 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 531844003755 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 531844003756 hexamer interface [polypeptide binding]; other site 531844003757 ligand binding site [chemical binding]; other site 531844003758 putative active site [active] 531844003759 NAD(P) binding site [chemical binding]; other site 531844003760 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 531844003761 prephenate dehydrogenase; Validated; Region: PRK08507 531844003762 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 531844003763 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 531844003764 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 531844003765 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 531844003766 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 531844003767 ABC1 family; Region: ABC1; cl17513 531844003768 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 531844003769 glucokinase, proteobacterial type; Region: glk; TIGR00749 531844003770 Glucokinase; Region: Glucokinase; cl17310 531844003771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 531844003772 active site residue [active] 531844003773 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 531844003774 4Fe-4S binding domain; Region: Fer4; pfam00037 531844003775 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 531844003776 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 531844003777 YceI-like domain; Region: YceI; cl01001 531844003778 YceI-like domain; Region: YceI; pfam04264 531844003779 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 531844003780 putative hydrolase; Provisional; Region: PRK02113 531844003781 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 531844003782 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 531844003783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 531844003784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 531844003785 Coenzyme A binding pocket [chemical binding]; other site 531844003786 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 531844003787 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 531844003788 E3 interaction surface; other site 531844003789 lipoyl attachment site [posttranslational modification]; other site 531844003790 e3 binding domain; Region: E3_binding; pfam02817 531844003791 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 531844003792 Uncharacterized conserved protein [Function unknown]; Region: COG1359 531844003793 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 531844003794 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 531844003795 substrate binding site [chemical binding]; other site 531844003796 active site 531844003797 catalytic residues [active] 531844003798 heterodimer interface [polypeptide binding]; other site 531844003799 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 531844003800 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 531844003801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844003802 catalytic residue [active] 531844003803 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 531844003804 active site 531844003805 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 531844003806 active site 531844003807 ribulose/triose binding site [chemical binding]; other site 531844003808 phosphate binding site [ion binding]; other site 531844003809 substrate (anthranilate) binding pocket [chemical binding]; other site 531844003810 product (indole) binding pocket [chemical binding]; other site 531844003811 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 531844003812 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 531844003813 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 531844003814 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 531844003815 Glutamine amidotransferase class-I; Region: GATase; pfam00117 531844003816 glutamine binding [chemical binding]; other site 531844003817 catalytic triad [active] 531844003818 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 531844003819 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 531844003820 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 531844003821 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 531844003822 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 531844003823 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 531844003824 dimer interface [polypeptide binding]; other site 531844003825 putative anticodon binding site; other site 531844003826 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 531844003827 motif 1; other site 531844003828 active site 531844003829 motif 2; other site 531844003830 motif 3; other site 531844003831 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003832 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 531844003833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844003834 ATP binding site [chemical binding]; other site 531844003835 Mg2+ binding site [ion binding]; other site 531844003836 G-X-G motif; other site 531844003837 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 531844003838 anchoring element; other site 531844003839 dimer interface [polypeptide binding]; other site 531844003840 ATP binding site [chemical binding]; other site 531844003841 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 531844003842 active site 531844003843 putative metal-binding site [ion binding]; other site 531844003844 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 531844003845 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 531844003846 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 531844003847 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 531844003848 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 531844003849 Transcriptional regulators [Transcription]; Region: MarR; COG1846 531844003850 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 531844003851 phytoene desaturase; Region: crtI_fam; TIGR02734 531844003852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 531844003853 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 531844003854 active site lid residues [active] 531844003855 substrate binding pocket [chemical binding]; other site 531844003856 catalytic residues [active] 531844003857 substrate-Mg2+ binding site; other site 531844003858 aspartate-rich region 1; other site 531844003859 aspartate-rich region 2; other site 531844003860 beta-carotene hydroxylase; Region: PLN02601 531844003861 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 531844003862 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 531844003863 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 531844003864 putative hydrophobic ligand binding site [chemical binding]; other site 531844003865 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 531844003866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844003867 NAD(P) binding site [chemical binding]; other site 531844003868 active site 531844003869 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 531844003870 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 531844003871 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 531844003872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 531844003873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844003874 NAD(P) binding site [chemical binding]; other site 531844003875 active site 531844003876 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 531844003877 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 531844003878 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844003879 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 531844003880 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 531844003881 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 531844003882 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 531844003883 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 531844003884 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 531844003885 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 531844003886 putative ion selectivity filter; other site 531844003887 putative pore gating glutamate residue; other site 531844003888 putative H+/Cl- coupling transport residue; other site 531844003889 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 531844003890 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 531844003891 active site 531844003892 FMN binding site [chemical binding]; other site 531844003893 substrate binding site [chemical binding]; other site 531844003894 3Fe-4S cluster binding site [ion binding]; other site 531844003895 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 531844003896 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 531844003897 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 531844003898 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 531844003899 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844003900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 531844003901 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 531844003902 Putative glucoamylase; Region: Glycoamylase; pfam10091 531844003903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 531844003904 Putative glucoamylase; Region: Glycoamylase; pfam10091 531844003905 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 531844003906 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 531844003907 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844003908 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844003909 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844003910 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844003911 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 531844003912 Protein of unknown function (DUF493); Region: DUF493; pfam04359 531844003913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844003914 TIGR01777 family protein; Region: yfcH 531844003915 NAD(P) binding site [chemical binding]; other site 531844003916 active site 531844003917 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 531844003918 ArsC family; Region: ArsC; pfam03960 531844003919 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 531844003920 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 531844003921 Substrate-binding site [chemical binding]; other site 531844003922 Substrate specificity [chemical binding]; other site 531844003923 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 531844003924 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 531844003925 Zn binding site [ion binding]; other site 531844003926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844003927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844003928 phosphorylation site [posttranslational modification] 531844003929 dimer interface [polypeptide binding]; other site 531844003930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844003931 ATP binding site [chemical binding]; other site 531844003932 Mg2+ binding site [ion binding]; other site 531844003933 G-X-G motif; other site 531844003934 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 531844003935 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 531844003936 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 531844003937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 531844003938 Zn2+ binding site [ion binding]; other site 531844003939 Mg2+ binding site [ion binding]; other site 531844003940 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 531844003941 synthetase active site [active] 531844003942 NTP binding site [chemical binding]; other site 531844003943 metal binding site [ion binding]; metal-binding site 531844003944 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 531844003945 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 531844003946 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 531844003947 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 531844003948 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 531844003949 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 531844003950 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 531844003951 Part of AAA domain; Region: AAA_19; pfam13245 531844003952 Family description; Region: UvrD_C_2; pfam13538 531844003953 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 531844003954 DNA-binding site [nucleotide binding]; DNA binding site 531844003955 RNA-binding motif; other site 531844003956 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 531844003957 DNA-binding site [nucleotide binding]; DNA binding site 531844003958 RNA-binding motif; other site 531844003959 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 531844003960 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 531844003961 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 531844003962 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 531844003963 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 531844003964 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 531844003965 Response regulator receiver domain; Region: Response_reg; pfam00072 531844003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844003967 active site 531844003968 phosphorylation site [posttranslational modification] 531844003969 intermolecular recognition site; other site 531844003970 dimerization interface [polypeptide binding]; other site 531844003971 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 531844003972 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 531844003973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 531844003974 putative active site [active] 531844003975 heme pocket [chemical binding]; other site 531844003976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844003977 dimer interface [polypeptide binding]; other site 531844003978 phosphorylation site [posttranslational modification] 531844003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844003980 ATP binding site [chemical binding]; other site 531844003981 Mg2+ binding site [ion binding]; other site 531844003982 G-X-G motif; other site 531844003983 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844003984 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 531844003985 Probable Catalytic site; other site 531844003986 metal-binding site 531844003987 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844003988 active site 531844003989 recombination protein RecR; Reviewed; Region: recR; PRK00076 531844003990 RecR protein; Region: RecR; pfam02132 531844003991 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 531844003992 putative active site [active] 531844003993 putative metal-binding site [ion binding]; other site 531844003994 tetramer interface [polypeptide binding]; other site 531844003995 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 531844003996 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 531844003997 metal binding site [ion binding]; metal-binding site 531844003998 dimer interface [polypeptide binding]; other site 531844003999 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 531844004000 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 531844004001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 531844004002 catalytic loop [active] 531844004003 iron binding site [ion binding]; other site 531844004004 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 531844004005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 531844004006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 531844004007 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 531844004008 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 531844004009 putative ligand binding site [chemical binding]; other site 531844004010 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 531844004011 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 531844004012 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 531844004013 dimer interface [polypeptide binding]; other site 531844004014 motif 1; other site 531844004015 active site 531844004016 motif 2; other site 531844004017 motif 3; other site 531844004018 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 531844004019 active site 531844004020 dimerization interface [polypeptide binding]; other site 531844004021 CAAX protease self-immunity; Region: Abi; pfam02517 531844004022 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 531844004023 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 531844004024 G1 box; other site 531844004025 putative GEF interaction site [polypeptide binding]; other site 531844004026 GTP/Mg2+ binding site [chemical binding]; other site 531844004027 Switch I region; other site 531844004028 G2 box; other site 531844004029 G3 box; other site 531844004030 Switch II region; other site 531844004031 G4 box; other site 531844004032 G5 box; other site 531844004033 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 531844004034 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 531844004035 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 531844004036 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 531844004037 FAD binding site [chemical binding]; other site 531844004038 homotetramer interface [polypeptide binding]; other site 531844004039 substrate binding pocket [chemical binding]; other site 531844004040 catalytic base [active] 531844004041 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 531844004042 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 531844004043 acyl-activating enzyme (AAE) consensus motif; other site 531844004044 putative AMP binding site [chemical binding]; other site 531844004045 putative active site [active] 531844004046 putative CoA binding site [chemical binding]; other site 531844004047 PAS domain; Region: PAS_10; pfam13596 531844004048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844004049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844004050 dimer interface [polypeptide binding]; other site 531844004051 phosphorylation site [posttranslational modification] 531844004052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844004053 ATP binding site [chemical binding]; other site 531844004054 Mg2+ binding site [ion binding]; other site 531844004055 G-X-G motif; other site 531844004056 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 531844004057 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 531844004058 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 531844004059 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 531844004060 Sulfate transporter family; Region: Sulfate_transp; pfam00916 531844004061 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 531844004062 Tetratrico peptide repeat; Region: TPR_5; pfam12688 531844004063 Sulphur transport; Region: Sulf_transp; pfam04143 531844004064 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 531844004065 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 531844004066 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 531844004067 active site residue [active] 531844004068 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 531844004069 active site residue [active] 531844004070 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 531844004071 active site residue [active] 531844004072 OsmC-like protein; Region: OsmC; pfam02566 531844004073 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 531844004074 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844004075 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844004076 ligand binding site [chemical binding]; other site 531844004077 flexible hinge region; other site 531844004078 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 531844004079 non-specific DNA interactions [nucleotide binding]; other site 531844004080 DNA binding site [nucleotide binding] 531844004081 sequence specific DNA binding site [nucleotide binding]; other site 531844004082 putative cAMP binding site [chemical binding]; other site 531844004083 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 531844004084 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 531844004085 S1 domain; Region: S1_2; pfam13509 531844004086 KTSC domain; Region: KTSC; pfam13619 531844004087 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 531844004088 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 531844004089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 531844004090 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 531844004091 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 531844004092 DinB superfamily; Region: DinB_2; pfam12867 531844004093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 531844004094 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 531844004095 dimer interface [polypeptide binding]; other site 531844004096 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 531844004097 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 531844004098 dimer interface [polypeptide binding]; other site 531844004099 active site 531844004100 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 531844004101 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 531844004102 catalytic site [active] 531844004103 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 531844004104 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 531844004105 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 531844004106 KpsF/GutQ family protein; Region: kpsF; TIGR00393 531844004107 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 531844004108 putative active site [active] 531844004109 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 531844004110 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 531844004111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844004112 ATP binding site [chemical binding]; other site 531844004113 putative Mg++ binding site [ion binding]; other site 531844004114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844004115 nucleotide binding region [chemical binding]; other site 531844004116 ATP-binding site [chemical binding]; other site 531844004117 RQC domain; Region: RQC; pfam09382 531844004118 HRDC domain; Region: HRDC; pfam00570 531844004119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844004120 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 531844004121 putative ADP-binding pocket [chemical binding]; other site 531844004122 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 531844004123 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 531844004124 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 531844004125 active site 531844004126 dimer interface [polypeptide binding]; other site 531844004127 effector binding site; other site 531844004128 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 531844004129 MG2 domain; Region: A2M_N; pfam01835 531844004130 Alpha-2-macroglobulin family; Region: A2M; pfam00207 531844004131 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 531844004132 recombination protein F; Reviewed; Region: recF; PRK00064 531844004133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844004134 Walker A/P-loop; other site 531844004135 ATP binding site [chemical binding]; other site 531844004136 Q-loop/lid; other site 531844004137 Protein of unknown function (DUF721); Region: DUF721; cl02324 531844004138 Site-specific recombinase; Region: SpecificRecomb; cl15411 531844004139 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 531844004140 Transglycosylase; Region: Transgly; cl17702 531844004141 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 531844004142 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 531844004143 intersubunit interface [polypeptide binding]; other site 531844004144 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 531844004145 Peptidase family M23; Region: Peptidase_M23; pfam01551 531844004146 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 531844004147 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 531844004148 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 531844004149 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 531844004150 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 531844004151 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 531844004152 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844004153 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 531844004154 peptide chain release factor 2; Validated; Region: prfB; PRK00578 531844004155 PCRF domain; Region: PCRF; pfam03462 531844004156 RF-1 domain; Region: RF-1; pfam00472 531844004157 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 531844004158 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 531844004159 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 531844004160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 531844004161 HSP70 interaction site [polypeptide binding]; other site 531844004162 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 531844004163 dimer interface [polypeptide binding]; other site 531844004164 GrpE; Region: GrpE; pfam01025 531844004165 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 531844004166 dimer interface [polypeptide binding]; other site 531844004167 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 531844004168 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 531844004169 manganese transport protein MntH; Reviewed; Region: PRK00701 531844004170 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 531844004171 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 531844004172 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 531844004173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 531844004174 ligand binding site [chemical binding]; other site 531844004175 prolyl-tRNA synthetase; Provisional; Region: PRK08661 531844004176 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 531844004177 dimer interface [polypeptide binding]; other site 531844004178 motif 1; other site 531844004179 active site 531844004180 motif 2; other site 531844004181 motif 3; other site 531844004182 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 531844004183 anticodon binding site; other site 531844004184 zinc-binding site [ion binding]; other site 531844004185 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 531844004186 ZIP Zinc transporter; Region: Zip; pfam02535 531844004187 Methyltransferase domain; Region: Methyltransf_23; pfam13489 531844004188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844004189 S-adenosylmethionine binding site [chemical binding]; other site 531844004190 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 531844004191 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 531844004192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 531844004193 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 531844004194 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844004195 active site 531844004196 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 531844004197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844004198 S-adenosylmethionine binding site [chemical binding]; other site 531844004199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 531844004200 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 531844004201 dimer interface [polypeptide binding]; other site 531844004202 substrate binding site [chemical binding]; other site 531844004203 metal binding site [ion binding]; metal-binding site 531844004204 Ribosome-binding factor A; Region: RBFA; pfam02033 531844004205 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 531844004206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 531844004207 FtsX-like permease family; Region: FtsX; pfam02687 531844004208 Endonuclease I; Region: Endonuclease_1; pfam04231 531844004209 Endonuclease I; Region: Endonuclease_1; pfam04231 531844004210 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844004211 Interdomain contacts; other site 531844004212 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004213 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 531844004214 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 531844004215 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 531844004216 shikimate binding site; other site 531844004217 NAD(P) binding site [chemical binding]; other site 531844004218 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 531844004219 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 531844004220 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 531844004221 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 531844004222 catalytic motif [active] 531844004223 Zn binding site [ion binding]; other site 531844004224 RibD C-terminal domain; Region: RibD_C; pfam01872 531844004225 Uncharacterized conserved protein [Function unknown]; Region: COG1739 531844004226 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 531844004227 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 531844004228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 531844004229 Coenzyme A binding pocket [chemical binding]; other site 531844004230 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 531844004231 NADH dehydrogenase subunit B; Provisional; Region: PRK14820 531844004232 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 531844004233 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 531844004234 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 531844004235 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 531844004236 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 531844004237 putative dimer interface [polypeptide binding]; other site 531844004238 [2Fe-2S] cluster binding site [ion binding]; other site 531844004239 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 531844004240 SLBB domain; Region: SLBB; pfam10531 531844004241 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 531844004242 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 531844004243 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 531844004244 catalytic loop [active] 531844004245 iron binding site [ion binding]; other site 531844004246 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 531844004247 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 531844004248 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 531844004249 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 531844004250 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 531844004251 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 531844004252 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 531844004253 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 531844004254 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 531844004255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 531844004256 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 531844004257 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 531844004258 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 531844004259 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 531844004260 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 531844004261 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 531844004262 dimer interface [polypeptide binding]; other site 531844004263 ssDNA binding site [nucleotide binding]; other site 531844004264 tetramer (dimer of dimers) interface [polypeptide binding]; other site 531844004265 HRDC domain; Region: HRDC; pfam00570 531844004266 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 531844004267 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 531844004268 dimer interface [polypeptide binding]; other site 531844004269 motif 1; other site 531844004270 active site 531844004271 motif 2; other site 531844004272 motif 3; other site 531844004273 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 531844004274 anticodon binding site; other site 531844004275 Methyltransferase domain; Region: Methyltransf_31; pfam13847 531844004276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844004277 S-adenosylmethionine binding site [chemical binding]; other site 531844004278 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 531844004279 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 531844004280 PhnA protein; Region: PhnA; pfam03831 531844004281 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 531844004282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844004283 Walker A/P-loop; other site 531844004284 ATP binding site [chemical binding]; other site 531844004285 Q-loop/lid; other site 531844004286 ABC transporter signature motif; other site 531844004287 Walker B; other site 531844004288 D-loop; other site 531844004289 H-loop/switch region; other site 531844004290 YceI-like domain; Region: YceI; pfam04264 531844004291 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 531844004292 Na binding site [ion binding]; other site 531844004293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 531844004294 Coenzyme A binding pocket [chemical binding]; other site 531844004295 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 531844004296 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 531844004297 tetramer interface [polypeptide binding]; other site 531844004298 heme binding pocket [chemical binding]; other site 531844004299 NADPH binding site [chemical binding]; other site 531844004300 Pirin-related protein [General function prediction only]; Region: COG1741 531844004301 Pirin; Region: Pirin; pfam02678 531844004302 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 531844004303 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 531844004304 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 531844004305 putative transporter; Provisional; Region: PRK10504 531844004306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844004307 putative substrate translocation pore; other site 531844004308 asparagine synthetase B; Provisional; Region: asnB; PRK09431 531844004309 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 531844004310 active site 531844004311 dimer interface [polypeptide binding]; other site 531844004312 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 531844004313 Ligand Binding Site [chemical binding]; other site 531844004314 Molecular Tunnel; other site 531844004315 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 531844004316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844004317 S-adenosylmethionine binding site [chemical binding]; other site 531844004318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844004319 active site 531844004320 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 531844004321 active site 531844004322 dimer interface [polypeptide binding]; other site 531844004323 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 531844004324 Beta-lactamase; Region: Beta-lactamase; pfam00144 531844004325 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 531844004326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 531844004327 catalytic core [active] 531844004328 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 531844004329 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 531844004330 active site 531844004331 catalytic residues [active] 531844004332 metal binding site [ion binding]; metal-binding site 531844004333 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 531844004334 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 531844004335 homodimer interface [polypeptide binding]; other site 531844004336 metal binding site [ion binding]; metal-binding site 531844004337 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 531844004338 homodimer interface [polypeptide binding]; other site 531844004339 active site 531844004340 putative chemical substrate binding site [chemical binding]; other site 531844004341 metal binding site [ion binding]; metal-binding site 531844004342 putative oxidoreductase; Provisional; Region: PRK11579 531844004343 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 531844004344 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 531844004345 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 531844004346 dimerization interface [polypeptide binding]; other site 531844004347 metal binding site [ion binding]; metal-binding site 531844004348 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 531844004349 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 531844004350 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 531844004351 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 531844004352 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 531844004353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844004355 ATP binding site [chemical binding]; other site 531844004356 Mg2+ binding site [ion binding]; other site 531844004357 G-X-G motif; other site 531844004358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 531844004359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004360 active site 531844004361 phosphorylation site [posttranslational modification] 531844004362 intermolecular recognition site; other site 531844004363 dimerization interface [polypeptide binding]; other site 531844004364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 531844004365 DNA binding residues [nucleotide binding] 531844004366 dimerization interface [polypeptide binding]; other site 531844004367 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 531844004368 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 531844004369 DXD motif; other site 531844004370 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004372 active site 531844004373 phosphorylation site [posttranslational modification] 531844004374 intermolecular recognition site; other site 531844004375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844004376 dimerization interface [polypeptide binding]; other site 531844004377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844004378 dimer interface [polypeptide binding]; other site 531844004379 phosphorylation site [posttranslational modification] 531844004380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844004381 ATP binding site [chemical binding]; other site 531844004382 Mg2+ binding site [ion binding]; other site 531844004383 G-X-G motif; other site 531844004384 CHASE3 domain; Region: CHASE3; pfam05227 531844004385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 531844004386 GAF domain; Region: GAF_2; pfam13185 531844004387 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 531844004388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844004389 dimer interface [polypeptide binding]; other site 531844004390 phosphorylation site [posttranslational modification] 531844004391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844004392 ATP binding site [chemical binding]; other site 531844004393 Mg2+ binding site [ion binding]; other site 531844004394 G-X-G motif; other site 531844004395 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004397 active site 531844004398 phosphorylation site [posttranslational modification] 531844004399 intermolecular recognition site; other site 531844004400 dimerization interface [polypeptide binding]; other site 531844004401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004402 active site 531844004403 phosphorylation site [posttranslational modification] 531844004404 intermolecular recognition site; other site 531844004405 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004407 active site 531844004408 phosphorylation site [posttranslational modification] 531844004409 intermolecular recognition site; other site 531844004410 dimerization interface [polypeptide binding]; other site 531844004411 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004413 active site 531844004414 phosphorylation site [posttranslational modification] 531844004415 intermolecular recognition site; other site 531844004416 dimerization interface [polypeptide binding]; other site 531844004417 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 531844004418 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 531844004419 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 531844004420 CheB methylesterase; Region: CheB_methylest; pfam01339 531844004421 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004423 active site 531844004424 phosphorylation site [posttranslational modification] 531844004425 intermolecular recognition site; other site 531844004426 dimerization interface [polypeptide binding]; other site 531844004427 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 531844004428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844004429 S-adenosylmethionine binding site [chemical binding]; other site 531844004430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 531844004431 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 531844004432 metal ion-dependent adhesion site (MIDAS); other site 531844004433 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 531844004434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 531844004435 salt bridge; other site 531844004436 non-specific DNA binding site [nucleotide binding]; other site 531844004437 sequence-specific DNA binding site [nucleotide binding]; other site 531844004438 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 531844004439 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 531844004440 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 531844004441 active site 531844004442 catalytic site [active] 531844004443 Aamy_C domain; Region: Aamy_C; smart00632 531844004444 Transposase IS200 like; Region: Y1_Tnp; cl00848 531844004445 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 531844004446 hypothetical protein; Provisional; Region: PRK07236 531844004447 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 531844004448 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 531844004449 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 531844004450 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 531844004451 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 531844004452 substrate binding site [chemical binding]; other site 531844004453 active site 531844004454 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 531844004455 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 531844004456 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 531844004457 Domain of unknown function (DUF303); Region: DUF303; pfam03629 531844004458 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 531844004459 Domain of unknown function (DUF303); Region: DUF303; pfam03629 531844004460 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 531844004461 active site 531844004462 catalytic residues [active] 531844004463 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 531844004464 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 531844004465 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 531844004466 inhibitor binding site; inhibition site 531844004467 active site 531844004468 D-mannonate oxidoreductase; Provisional; Region: PRK08277 531844004469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844004470 NAD(P) binding site [chemical binding]; other site 531844004471 active site 531844004472 mannonate dehydratase; Provisional; Region: PRK03906 531844004473 mannonate dehydratase; Region: uxuA; TIGR00695 531844004474 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 531844004475 starch binding outer membrane protein SusD; Region: SusD; cl17845 531844004476 SusD family; Region: SusD; pfam07980 531844004477 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844004478 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844004479 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 531844004480 xylose isomerase; Provisional; Region: PRK05474 531844004481 xylose isomerase; Region: xylose_isom_A; TIGR02630 531844004482 D-xylulose kinases, subgroup 2; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810 531844004483 putative N- and C-terminal domain interface [polypeptide binding]; other site 531844004484 D-xylulose kinase; Region: XylB; TIGR01312 531844004485 putative active site [active] 531844004486 putative MgATP binding site [chemical binding]; other site 531844004487 catalytic site [active] 531844004488 metal binding site [ion binding]; metal-binding site 531844004489 putative xylulose binding site [chemical binding]; other site 531844004490 putative homodimer interface [polypeptide binding]; other site 531844004491 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 531844004492 nudix motif; other site 531844004493 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 531844004494 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 531844004495 HSP70 interaction site [polypeptide binding]; other site 531844004496 KTSC domain; Region: KTSC; pfam13619 531844004497 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 531844004498 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 531844004499 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 531844004500 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 531844004501 active site 531844004502 HIGH motif; other site 531844004503 dimer interface [polypeptide binding]; other site 531844004504 KMSKS motif; other site 531844004505 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 531844004506 RNA binding surface [nucleotide binding]; other site 531844004507 Fatty acid desaturase; Region: FA_desaturase; pfam00487 531844004508 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 531844004509 Di-iron ligands [ion binding]; other site 531844004510 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 531844004511 putative hydrolase; Provisional; Region: PRK11460 531844004512 Predicted esterase [General function prediction only]; Region: COG0400 531844004513 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 531844004514 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 531844004515 Putative esterase; Region: Esterase; pfam00756 531844004516 AIR carboxylase; Region: AIRC; pfam00731 531844004517 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 531844004518 EamA-like transporter family; Region: EamA; pfam00892 531844004519 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 531844004520 ATP-grasp domain; Region: ATP-grasp_4; cl17255 531844004521 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 531844004522 putative catalytic site [active] 531844004523 putative phosphate binding site [ion binding]; other site 531844004524 putative metal binding site [ion binding]; other site 531844004525 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 531844004526 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 531844004527 CoenzymeA binding site [chemical binding]; other site 531844004528 subunit interaction site [polypeptide binding]; other site 531844004529 PHB binding site; other site 531844004530 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 531844004531 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 531844004532 putative acyl-acceptor binding pocket; other site 531844004533 PspC domain; Region: PspC; pfam04024 531844004534 Predicted transcriptional regulators [Transcription]; Region: COG1695 531844004535 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 531844004536 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 531844004537 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844004538 Interdomain contacts; other site 531844004539 Cytokine receptor motif; other site 531844004540 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004541 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844004542 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844004543 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 531844004544 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 531844004545 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 531844004546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 531844004547 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 531844004548 Peptidase family M1; Region: Peptidase_M1; pfam01433 531844004549 Zn binding site [ion binding]; other site 531844004550 HEAT repeats; Region: HEAT_2; pfam13646 531844004551 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 531844004552 Beta-lactamase; Region: Beta-lactamase; pfam00144 531844004553 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 531844004554 thymidylate synthase; Reviewed; Region: thyA; PRK01827 531844004555 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 531844004556 dimerization interface [polypeptide binding]; other site 531844004557 active site 531844004558 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 531844004559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844004560 TPR motif; other site 531844004561 binding surface 531844004562 Sulfatase; Region: Sulfatase; cl17466 531844004563 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 531844004564 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 531844004565 DXD motif; other site 531844004566 HEAT repeats; Region: HEAT_2; pfam13646 531844004567 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004569 active site 531844004570 phosphorylation site [posttranslational modification] 531844004571 intermolecular recognition site; other site 531844004572 dimerization interface [polypeptide binding]; other site 531844004573 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 531844004574 GAF domain; Region: GAF; pfam01590 531844004575 PAS domain; Region: PAS_9; pfam13426 531844004576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 531844004577 PAS domain; Region: PAS_9; pfam13426 531844004578 putative active site [active] 531844004579 heme pocket [chemical binding]; other site 531844004580 PAS fold; Region: PAS_3; pfam08447 531844004581 PAS fold; Region: PAS_4; pfam08448 531844004582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844004583 dimer interface [polypeptide binding]; other site 531844004584 phosphorylation site [posttranslational modification] 531844004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844004586 ATP binding site [chemical binding]; other site 531844004587 Mg2+ binding site [ion binding]; other site 531844004588 G-X-G motif; other site 531844004589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 531844004590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004591 active site 531844004592 phosphorylation site [posttranslational modification] 531844004593 intermolecular recognition site; other site 531844004594 dimerization interface [polypeptide binding]; other site 531844004595 Response regulator receiver domain; Region: Response_reg; pfam00072 531844004596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004597 active site 531844004598 phosphorylation site [posttranslational modification] 531844004599 intermolecular recognition site; other site 531844004600 dimerization interface [polypeptide binding]; other site 531844004601 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 531844004602 putative binding surface; other site 531844004603 active site 531844004604 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 531844004605 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 531844004606 active site 531844004607 catalytic site [active] 531844004608 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 531844004609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844004610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844004611 dimer interface [polypeptide binding]; other site 531844004612 phosphorylation site [posttranslational modification] 531844004613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844004614 ATP binding site [chemical binding]; other site 531844004615 Mg2+ binding site [ion binding]; other site 531844004616 G-X-G motif; other site 531844004617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 531844004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844004619 active site 531844004620 phosphorylation site [posttranslational modification] 531844004621 intermolecular recognition site; other site 531844004622 dimerization interface [polypeptide binding]; other site 531844004623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 531844004624 DNA binding site [nucleotide binding] 531844004625 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844004626 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844004627 Barstar (barnase inhibitor); Region: Barstar; pfam01337 531844004628 RNAase interaction site [polypeptide binding]; other site 531844004629 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 531844004630 active site 531844004631 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 531844004632 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 531844004633 homodimer interface [polypeptide binding]; other site 531844004634 NAD binding pocket [chemical binding]; other site 531844004635 ATP binding pocket [chemical binding]; other site 531844004636 Mg binding site [ion binding]; other site 531844004637 active-site loop [active] 531844004638 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 531844004639 gliding motility-associated protein GldC; Region: GldC; TIGR03515 531844004640 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 531844004641 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 531844004642 homodimer interface [polypeptide binding]; other site 531844004643 substrate-cofactor binding pocket; other site 531844004644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844004645 catalytic residue [active] 531844004646 DinB superfamily; Region: DinB_2; pfam12867 531844004647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 531844004648 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 531844004649 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 531844004650 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 531844004651 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 531844004652 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844004653 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 531844004654 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 531844004655 active site 531844004656 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 531844004657 competence damage-inducible protein A; Provisional; Region: PRK00549 531844004658 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 531844004659 putative MPT binding site; other site 531844004660 Competence-damaged protein; Region: CinA; pfam02464 531844004661 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 531844004662 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 531844004663 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 531844004664 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 531844004665 putative active site [active] 531844004666 putative metal binding site [ion binding]; other site 531844004667 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 531844004668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844004669 ATP binding site [chemical binding]; other site 531844004670 putative Mg++ binding site [ion binding]; other site 531844004671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844004672 nucleotide binding region [chemical binding]; other site 531844004673 ATP-binding site [chemical binding]; other site 531844004674 DEAD/H associated; Region: DEAD_assoc; pfam08494 531844004675 ATP-dependent DNA ligase; Validated; Region: PRK09247 531844004676 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 531844004677 active site 531844004678 DNA binding site [nucleotide binding] 531844004679 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 531844004680 DNA binding site [nucleotide binding] 531844004681 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 531844004682 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 531844004683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 531844004684 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 531844004685 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 531844004686 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 531844004687 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 531844004688 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 531844004689 lipoyl synthase; Provisional; Region: PRK05481 531844004690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844004691 FeS/SAM binding site; other site 531844004692 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 531844004693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844004694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 531844004695 DNA binding residues [nucleotide binding] 531844004696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 531844004697 Histidine kinase; Region: HisKA_2; pfam07568 531844004698 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 531844004699 Class I ribonucleotide reductase; Region: RNR_I; cd01679 531844004700 active site 531844004701 dimer interface [polypeptide binding]; other site 531844004702 catalytic residues [active] 531844004703 effector binding site; other site 531844004704 R2 peptide binding site; other site 531844004705 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 531844004706 dimer interface [polypeptide binding]; other site 531844004707 putative radical transfer pathway; other site 531844004708 diiron center [ion binding]; other site 531844004709 tyrosyl radical; other site 531844004710 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 531844004711 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 531844004712 Walker A/P-loop; other site 531844004713 ATP binding site [chemical binding]; other site 531844004714 Q-loop/lid; other site 531844004715 ABC transporter signature motif; other site 531844004716 Walker B; other site 531844004717 D-loop; other site 531844004718 H-loop/switch region; other site 531844004719 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 531844004720 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 531844004721 FtsX-like permease family; Region: FtsX; pfam02687 531844004722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 531844004723 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 531844004724 FtsX-like permease family; Region: FtsX; pfam02687 531844004725 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 531844004726 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 531844004727 HlyD family secretion protein; Region: HlyD_3; pfam13437 531844004728 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 531844004729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 531844004730 Zn2+ binding site [ion binding]; other site 531844004731 Mg2+ binding site [ion binding]; other site 531844004732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 531844004733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 531844004734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844004735 Walker A/P-loop; other site 531844004736 ATP binding site [chemical binding]; other site 531844004737 Q-loop/lid; other site 531844004738 ABC transporter signature motif; other site 531844004739 Walker B; other site 531844004740 D-loop; other site 531844004741 H-loop/switch region; other site 531844004742 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 531844004743 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 531844004744 Walker A/P-loop; other site 531844004745 ATP binding site [chemical binding]; other site 531844004746 Q-loop/lid; other site 531844004747 ABC transporter signature motif; other site 531844004748 Walker B; other site 531844004749 D-loop; other site 531844004750 H-loop/switch region; other site 531844004751 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 531844004752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844004753 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 531844004754 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 531844004755 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 531844004756 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 531844004757 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 531844004758 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 531844004759 putative dimer interface [polypeptide binding]; other site 531844004760 putative anticodon binding site; other site 531844004761 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 531844004762 homodimer interface [polypeptide binding]; other site 531844004763 motif 1; other site 531844004764 motif 2; other site 531844004765 active site 531844004766 motif 3; other site 531844004767 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 531844004768 RimM N-terminal domain; Region: RimM; pfam01782 531844004769 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 531844004770 Amino acid permease; Region: AA_permease_2; pfam13520 531844004771 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 531844004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844004773 Walker A/P-loop; other site 531844004774 ATP binding site [chemical binding]; other site 531844004775 Q-loop/lid; other site 531844004776 ABC transporter signature motif; other site 531844004777 Walker B; other site 531844004778 D-loop; other site 531844004779 H-loop/switch region; other site 531844004780 ABC transporter; Region: ABC_tran_2; pfam12848 531844004781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 531844004782 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 531844004783 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 531844004784 active site 531844004785 Archaeal ATPase; Region: Arch_ATPase; pfam01637 531844004786 AAA ATPase domain; Region: AAA_16; pfam13191 531844004787 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 531844004788 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 531844004789 NAD(P) binding site [chemical binding]; other site 531844004790 catalytic residues [active] 531844004791 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 531844004792 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 531844004793 NAD(P) binding site [chemical binding]; other site 531844004794 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 531844004795 intersubunit interface [polypeptide binding]; other site 531844004796 active site 531844004797 catalytic residue [active] 531844004798 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 531844004799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 531844004800 dimerization interface [polypeptide binding]; other site 531844004801 putative DNA binding site [nucleotide binding]; other site 531844004802 putative Zn2+ binding site [ion binding]; other site 531844004803 AsnC family; Region: AsnC_trans_reg; pfam01037 531844004804 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 531844004805 putative catalytic site [active] 531844004806 putative metal binding site [ion binding]; other site 531844004807 putative phosphate binding site [ion binding]; other site 531844004808 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 531844004809 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 531844004810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 531844004811 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004812 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 531844004813 dimer interface [polypeptide binding]; other site 531844004814 allosteric magnesium binding site [ion binding]; other site 531844004815 active site 531844004816 aspartate-rich active site metal binding site; other site 531844004817 Schiff base residues; other site 531844004818 TM2 domain; Region: TM2; cl00984 531844004819 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 531844004820 FMN binding site [chemical binding]; other site 531844004821 dimer interface [polypeptide binding]; other site 531844004822 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 531844004823 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 531844004824 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 531844004825 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 531844004826 DinB superfamily; Region: DinB_2; pfam12867 531844004827 MoxR-like ATPases [General function prediction only]; Region: COG0714 531844004828 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 531844004829 Walker A motif; other site 531844004830 ATP binding site [chemical binding]; other site 531844004831 Walker B motif; other site 531844004832 arginine finger; other site 531844004833 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 531844004834 Protein of unknown function DUF58; Region: DUF58; pfam01882 531844004835 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 531844004836 metal ion-dependent adhesion site (MIDAS); other site 531844004837 Oxygen tolerance; Region: BatD; pfam13584 531844004838 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 531844004839 metal ion-dependent adhesion site (MIDAS); other site 531844004840 von Willebrand factor type A domain; Region: VWA_2; pfam13519 531844004841 metal ion-dependent adhesion site (MIDAS); other site 531844004842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844004843 binding surface 531844004844 TPR motif; other site 531844004845 TPR repeat; Region: TPR_11; pfam13414 531844004846 Oxygen tolerance; Region: BatD; pfam13584 531844004847 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 531844004848 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 531844004849 diphosphomevalonate decarboxylase; Region: PLN02407 531844004850 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 531844004851 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 531844004852 acyl-activating enzyme (AAE) consensus motif; other site 531844004853 putative AMP binding site [chemical binding]; other site 531844004854 putative active site [active] 531844004855 putative CoA binding site [chemical binding]; other site 531844004856 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 531844004857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844004858 NAD(P) binding site [chemical binding]; other site 531844004859 active site 531844004860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 531844004861 PGAP1-like protein; Region: PGAP1; pfam07819 531844004862 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 531844004863 active site 531844004864 hydrophilic channel; other site 531844004865 dimerization interface [polypeptide binding]; other site 531844004866 catalytic residues [active] 531844004867 active site lid [active] 531844004868 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 531844004869 Mechanosensitive ion channel; Region: MS_channel; pfam00924 531844004870 Protein of unknown function (DUF456); Region: DUF456; pfam04306 531844004871 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 531844004872 ligand binding site [chemical binding]; other site 531844004873 active site 531844004874 UGI interface [polypeptide binding]; other site 531844004875 catalytic site [active] 531844004876 MutS domain III; Region: MutS_III; cl17822 531844004877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844004878 Walker A/P-loop; other site 531844004879 ATP binding site [chemical binding]; other site 531844004880 Q-loop/lid; other site 531844004881 ABC transporter signature motif; other site 531844004882 Walker B; other site 531844004883 D-loop; other site 531844004884 H-loop/switch region; other site 531844004885 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 531844004886 active site 531844004887 catalytic triad [active] 531844004888 Pectic acid lyase; Region: Pec_lyase; pfam09492 531844004889 putative pectinesterase; Region: PLN02432; cl01911 531844004890 Pectinesterase; Region: Pectinesterase; pfam01095 531844004891 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 531844004892 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 531844004893 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844004894 Pectate lyase; Region: Pec_lyase_C; cl01593 531844004895 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004896 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004897 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004898 Pectate lyase; Region: Pec_lyase_C; cl01593 531844004899 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004900 putative pectinesterase; Region: PLN02432; cl01911 531844004901 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844004902 starch binding outer membrane protein SusD; Region: SusD; cl17845 531844004903 SusD family; Region: SusD; pfam07980 531844004904 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844004905 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844004906 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844004907 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 531844004908 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 531844004909 Transcriptional regulators [Transcription]; Region: PurR; COG1609 531844004910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 531844004911 DNA binding site [nucleotide binding] 531844004912 domain linker motif; other site 531844004913 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 531844004914 ligand binding site [chemical binding]; other site 531844004915 dimerization interface [polypeptide binding]; other site 531844004916 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 531844004917 galactarate dehydratase; Region: galactar-dH20; TIGR03248 531844004918 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 531844004919 altronate oxidoreductase; Provisional; Region: PRK03643 531844004920 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 531844004921 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 531844004922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844004923 putative substrate translocation pore; other site 531844004924 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 531844004925 active site 531844004926 Entner-Doudoroff aldolase; Region: eda; TIGR01182 531844004927 intersubunit interface [polypeptide binding]; other site 531844004928 catalytic residue [active] 531844004929 Domain of unknown function (DUF386); Region: DUF386; cl01047 531844004930 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 531844004931 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 531844004932 substrate binding site [chemical binding]; other site 531844004933 ATP binding site [chemical binding]; other site 531844004934 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 531844004935 Glucuronate isomerase; Region: UxaC; pfam02614 531844004936 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 531844004937 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 531844004938 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 531844004939 NADP binding site [chemical binding]; other site 531844004940 homodimer interface [polypeptide binding]; other site 531844004941 active site 531844004942 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 531844004943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 531844004944 putative acyl-acceptor binding pocket; other site 531844004945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 531844004946 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 531844004947 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 531844004948 nucleotide binding site [chemical binding]; other site 531844004949 substrate binding site [chemical binding]; other site 531844004950 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 531844004951 AMP binding site [chemical binding]; other site 531844004952 metal binding site [ion binding]; metal-binding site 531844004953 active site 531844004954 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 531844004955 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 531844004956 active site 531844004957 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844004958 glutaminyl-tRNA synthetase; Region: glnS; TIGR00440 531844004959 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844004960 active site 531844004961 KMSKS motif; other site 531844004962 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 531844004963 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 531844004964 catalytic residues [active] 531844004965 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 531844004966 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 531844004967 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 531844004968 FMN binding site [chemical binding]; other site 531844004969 active site 531844004970 catalytic residues [active] 531844004971 substrate binding site [chemical binding]; other site 531844004972 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 531844004973 dimer interface [polypeptide binding]; other site 531844004974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 531844004975 ligand binding site [chemical binding]; other site 531844004976 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 531844004977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844004978 Walker A/P-loop; other site 531844004979 ATP binding site [chemical binding]; other site 531844004980 Q-loop/lid; other site 531844004981 ABC transporter signature motif; other site 531844004982 Walker B; other site 531844004983 D-loop; other site 531844004984 H-loop/switch region; other site 531844004985 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 531844004986 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 531844004987 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 531844004988 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 531844004989 CoA binding domain; Region: CoA_binding; smart00881 531844004990 CoA-ligase; Region: Ligase_CoA; pfam00549 531844004991 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 531844004992 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 531844004993 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 531844004994 trimer interface [polypeptide binding]; other site 531844004995 active site 531844004996 UDP-GlcNAc binding site [chemical binding]; other site 531844004997 lipid binding site [chemical binding]; lipid-binding site 531844004998 elongation factor P; Validated; Region: PRK00529 531844004999 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 531844005000 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 531844005001 RNA binding site [nucleotide binding]; other site 531844005002 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 531844005003 RNA binding site [nucleotide binding]; other site 531844005004 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 531844005005 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 531844005006 active site 531844005007 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 531844005008 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 531844005009 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 531844005010 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 531844005011 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 531844005012 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 531844005013 trimer interface [polypeptide binding]; other site 531844005014 active site 531844005015 UDP-GlcNAc binding site [chemical binding]; other site 531844005016 lipid binding site [chemical binding]; lipid-binding site 531844005017 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 531844005018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 531844005019 Zn2+ binding site [ion binding]; other site 531844005020 Mg2+ binding site [ion binding]; other site 531844005021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844005022 Response regulator receiver domain; Region: Response_reg; pfam00072 531844005023 active site 531844005024 phosphorylation site [posttranslational modification] 531844005025 intermolecular recognition site; other site 531844005026 dimerization interface [polypeptide binding]; other site 531844005027 PglZ domain; Region: PglZ; pfam08665 531844005028 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 531844005029 putative catalytic site [active] 531844005030 putative metal binding site [ion binding]; other site 531844005031 putative phosphate binding site [ion binding]; other site 531844005032 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 531844005033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844005034 putative homodimer interface [polypeptide binding]; other site 531844005035 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 531844005036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 531844005037 UDP-galactopyranose mutase; Region: GLF; pfam03275 531844005038 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844005039 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 531844005040 active site 531844005041 HIGH motif; other site 531844005042 nucleotide binding site [chemical binding]; other site 531844005043 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 531844005044 dimerization interface [polypeptide binding]; other site 531844005045 metal binding site [ion binding]; metal-binding site 531844005046 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 531844005047 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 531844005048 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 531844005049 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 531844005050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844005051 FeS/SAM binding site; other site 531844005052 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 531844005053 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 531844005054 substrate binding site; other site 531844005055 tetramer interface; other site 531844005056 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 531844005057 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 531844005058 NAD binding site [chemical binding]; other site 531844005059 substrate binding site [chemical binding]; other site 531844005060 homodimer interface [polypeptide binding]; other site 531844005061 active site 531844005062 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 531844005063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 531844005064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 531844005065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 531844005066 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 531844005067 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 531844005068 Mg++ binding site [ion binding]; other site 531844005069 putative catalytic motif [active] 531844005070 putative substrate binding site [chemical binding]; other site 531844005071 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 531844005072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844005073 NAD(P) binding site [chemical binding]; other site 531844005074 active site 531844005075 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 531844005076 metal-binding site 531844005077 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 531844005078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844005079 NAD(P) binding site [chemical binding]; other site 531844005080 active site 531844005081 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844005082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844005083 active site 531844005084 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 531844005085 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 531844005086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844005087 active site 531844005088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844005089 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 531844005090 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 531844005091 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 531844005092 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 531844005093 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 531844005094 inhibitor-cofactor binding pocket; inhibition site 531844005095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844005096 catalytic residue [active] 531844005097 WxcM-like, C-terminal; Region: FdtA; pfam05523 531844005098 WxcM-like, C-terminal; Region: FdtA; pfam05523 531844005099 tyrosine kinase; Provisional; Region: PRK11519 531844005100 Chain length determinant protein; Region: Wzz; pfam02706 531844005101 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 531844005102 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 531844005103 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 531844005104 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 531844005105 SLBB domain; Region: SLBB; pfam10531 531844005106 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 531844005107 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 531844005108 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 531844005109 NAD(P) binding site [chemical binding]; other site 531844005110 homodimer interface [polypeptide binding]; other site 531844005111 substrate binding site [chemical binding]; other site 531844005112 active site 531844005113 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 531844005114 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 531844005115 inhibitor-cofactor binding pocket; inhibition site 531844005116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844005117 catalytic residue [active] 531844005118 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 531844005119 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005120 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005121 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005122 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844005123 Interdomain contacts; other site 531844005124 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005125 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 531844005126 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 531844005127 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 531844005128 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844005129 Interdomain contacts; other site 531844005130 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 531844005131 23S rRNA interface [nucleotide binding]; other site 531844005132 L3 interface [polypeptide binding]; other site 531844005133 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 531844005134 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 531844005135 rRNA interaction site [nucleotide binding]; other site 531844005136 S8 interaction site; other site 531844005137 putative laminin-1 binding site; other site 531844005138 GLPGLI family protein; Region: GLPGLI; TIGR01200 531844005139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844005140 S-adenosylmethionine binding site [chemical binding]; other site 531844005141 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 531844005142 active site 531844005143 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 531844005144 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 531844005145 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005146 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 531844005147 TRAM domain; Region: TRAM; pfam01938 531844005148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844005149 S-adenosylmethionine binding site [chemical binding]; other site 531844005150 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 531844005151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 531844005152 catalytic residues [active] 531844005153 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 531844005154 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 531844005155 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 531844005156 L-aspartate oxidase; Provisional; Region: PRK06175 531844005157 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 531844005158 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 531844005159 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 531844005160 putative Iron-sulfur protein interface [polypeptide binding]; other site 531844005161 proximal heme binding site [chemical binding]; other site 531844005162 distal heme binding site [chemical binding]; other site 531844005163 putative dimer interface [polypeptide binding]; other site 531844005164 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 531844005165 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 531844005166 Competence protein; Region: Competence; pfam03772 531844005167 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 531844005168 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 531844005169 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 531844005170 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 531844005171 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 531844005172 Staphylococcal nuclease homologues; Region: SNc; smart00318 531844005173 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 531844005174 Catalytic site; other site 531844005175 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 531844005176 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 531844005177 dimer interface [polypeptide binding]; other site 531844005178 anticodon binding site; other site 531844005179 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 531844005180 homodimer interface [polypeptide binding]; other site 531844005181 motif 1; other site 531844005182 active site 531844005183 motif 2; other site 531844005184 GAD domain; Region: GAD; pfam02938 531844005185 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 531844005186 motif 3; other site 531844005187 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 531844005188 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 531844005189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844005190 short chain dehydrogenase; Provisional; Region: PRK07024 531844005191 NAD(P) binding site [chemical binding]; other site 531844005192 active site 531844005193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 531844005194 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 531844005195 substrate binding site [chemical binding]; other site 531844005196 oxyanion hole (OAH) forming residues; other site 531844005197 trimer interface [polypeptide binding]; other site 531844005198 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 531844005199 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 531844005200 substrate binding site [chemical binding]; other site 531844005201 dimer interface [polypeptide binding]; other site 531844005202 NADP binding site [chemical binding]; other site 531844005203 catalytic residues [active] 531844005204 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 531844005205 active site 2 [active] 531844005206 active site 1 [active] 531844005207 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 531844005208 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 531844005209 dimer interface [polypeptide binding]; other site 531844005210 Citrate synthase; Region: Citrate_synt; pfam00285 531844005211 active site 531844005212 citrylCoA binding site [chemical binding]; other site 531844005213 NADH binding [chemical binding]; other site 531844005214 cationic pore residues; other site 531844005215 oxalacetate/citrate binding site [chemical binding]; other site 531844005216 coenzyme A binding site [chemical binding]; other site 531844005217 catalytic triad [active] 531844005218 enolase; Provisional; Region: eno; PRK00077 531844005219 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 531844005220 dimer interface [polypeptide binding]; other site 531844005221 metal binding site [ion binding]; metal-binding site 531844005222 substrate binding pocket [chemical binding]; other site 531844005223 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 531844005224 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 531844005225 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 531844005226 alphaNTD - beta interaction site [polypeptide binding]; other site 531844005227 alphaNTD homodimer interface [polypeptide binding]; other site 531844005228 alphaNTD - beta' interaction site [polypeptide binding]; other site 531844005229 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 531844005230 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 531844005231 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 531844005232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 531844005233 RNA binding surface [nucleotide binding]; other site 531844005234 30S ribosomal protein S11; Validated; Region: PRK05309 531844005235 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 531844005236 30S ribosomal protein S13; Region: bact_S13; TIGR03631 531844005237 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 531844005238 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 531844005239 rRNA binding site [nucleotide binding]; other site 531844005240 predicted 30S ribosome binding site; other site 531844005241 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 531844005242 SecY translocase; Region: SecY; pfam00344 531844005243 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 531844005244 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 531844005245 23S rRNA binding site [nucleotide binding]; other site 531844005246 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 531844005247 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 531844005248 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 531844005249 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 531844005250 5S rRNA interface [nucleotide binding]; other site 531844005251 L27 interface [polypeptide binding]; other site 531844005252 23S rRNA interface [nucleotide binding]; other site 531844005253 L5 interface [polypeptide binding]; other site 531844005254 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 531844005255 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 531844005256 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 531844005257 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 531844005258 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 531844005259 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 531844005260 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 531844005261 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 531844005262 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 531844005263 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 531844005264 RNA binding site [nucleotide binding]; other site 531844005265 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 531844005266 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 531844005267 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 531844005268 23S rRNA interface [nucleotide binding]; other site 531844005269 putative translocon interaction site; other site 531844005270 signal recognition particle (SRP54) interaction site; other site 531844005271 L23 interface [polypeptide binding]; other site 531844005272 trigger factor interaction site; other site 531844005273 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 531844005274 23S rRNA interface [nucleotide binding]; other site 531844005275 5S rRNA interface [nucleotide binding]; other site 531844005276 putative antibiotic binding site [chemical binding]; other site 531844005277 L25 interface [polypeptide binding]; other site 531844005278 L27 interface [polypeptide binding]; other site 531844005279 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 531844005280 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 531844005281 G-X-X-G motif; other site 531844005282 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 531844005283 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 531844005284 putative translocon binding site; other site 531844005285 protein-rRNA interface [nucleotide binding]; other site 531844005286 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 531844005287 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 531844005288 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 531844005289 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 531844005290 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 531844005291 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 531844005292 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 531844005293 GLPGLI family protein; Region: GLPGLI; TIGR01200 531844005294 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 531844005295 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 531844005296 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 531844005297 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 531844005298 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 531844005299 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 531844005300 N-terminal plug; other site 531844005301 ligand-binding site [chemical binding]; other site 531844005302 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 531844005303 elongation factor G; Reviewed; Region: PRK12739 531844005304 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 531844005305 G1 box; other site 531844005306 putative GEF interaction site [polypeptide binding]; other site 531844005307 GTP/Mg2+ binding site [chemical binding]; other site 531844005308 Switch I region; other site 531844005309 G2 box; other site 531844005310 G3 box; other site 531844005311 Switch II region; other site 531844005312 G4 box; other site 531844005313 G5 box; other site 531844005314 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 531844005315 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 531844005316 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 531844005317 30S ribosomal protein S7; Validated; Region: PRK05302 531844005318 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 531844005319 S17 interaction site [polypeptide binding]; other site 531844005320 S8 interaction site; other site 531844005321 16S rRNA interaction site [nucleotide binding]; other site 531844005322 streptomycin interaction site [chemical binding]; other site 531844005323 23S rRNA interaction site [nucleotide binding]; other site 531844005324 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 531844005325 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 531844005326 Leucine rich repeat; Region: LRR_8; pfam13855 531844005327 Substrate binding site [chemical binding]; other site 531844005328 Leucine rich repeat; Region: LRR_8; pfam13855 531844005329 Leucine rich repeat; Region: LRR_8; pfam13855 531844005330 Immunoglobulin domain; Region: Ig_2; pfam13895 531844005331 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005332 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 531844005333 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 531844005334 dimerization interface [polypeptide binding]; other site 531844005335 DPS ferroxidase diiron center [ion binding]; other site 531844005336 ion pore; other site 531844005337 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 531844005338 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 531844005339 active site 531844005340 YCII-related domain; Region: YCII; pfam03795 531844005341 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 531844005342 RmuC family; Region: RmuC; pfam02646 531844005343 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 531844005344 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 531844005345 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 531844005346 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 531844005347 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 531844005348 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 531844005349 active site residue [active] 531844005350 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 531844005351 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 531844005352 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 531844005353 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 531844005354 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 531844005355 homodimer interface [polypeptide binding]; other site 531844005356 metal binding site [ion binding]; metal-binding site 531844005357 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 531844005358 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 531844005359 hinge; other site 531844005360 active site 531844005361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844005362 short chain dehydrogenase; Provisional; Region: PRK06179 531844005363 NAD(P) binding site [chemical binding]; other site 531844005364 active site 531844005365 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 531844005366 FAD binding site [chemical binding]; other site 531844005367 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 531844005368 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 531844005369 substrate binding pocket [chemical binding]; other site 531844005370 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 531844005371 B12 binding site [chemical binding]; other site 531844005372 cobalt ligand [ion binding]; other site 531844005373 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 531844005374 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 531844005375 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 531844005376 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 531844005377 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 531844005378 Predicted acetyltransferase [General function prediction only]; Region: COG2388 531844005379 Transcriptional regulator; Region: Transcrip_reg; pfam01709 531844005380 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 531844005381 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 531844005382 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 531844005383 ligand binding site [chemical binding]; other site 531844005384 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 531844005385 SmpB-tmRNA interface; other site 531844005386 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 531844005387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844005388 Walker A/P-loop; other site 531844005389 ATP binding site [chemical binding]; other site 531844005390 Q-loop/lid; other site 531844005391 ABC transporter signature motif; other site 531844005392 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 531844005393 ABC transporter; Region: ABC_tran_2; pfam12848 531844005394 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 531844005395 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 531844005396 DHH family; Region: DHH; pfam01368 531844005397 DHHA1 domain; Region: DHHA1; pfam02272 531844005398 Dehydroquinase class II; Region: DHquinase_II; pfam01220 531844005399 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 531844005400 trimer interface [polypeptide binding]; other site 531844005401 active site 531844005402 dimer interface [polypeptide binding]; other site 531844005403 Family of unknown function (DUF490); Region: DUF490; pfam04357 531844005404 Surface antigen; Region: Bac_surface_Ag; pfam01103 531844005405 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 531844005406 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 531844005407 lipoyl attachment site [posttranslational modification]; other site 531844005408 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 531844005409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 531844005410 NAD(P) binding site [chemical binding]; other site 531844005411 catalytic residues [active] 531844005412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 531844005413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 531844005414 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 531844005415 Walker A/P-loop; other site 531844005416 ATP binding site [chemical binding]; other site 531844005417 Q-loop/lid; other site 531844005418 ABC transporter signature motif; other site 531844005419 Walker B; other site 531844005420 D-loop; other site 531844005421 H-loop/switch region; other site 531844005422 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 531844005423 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 531844005424 dimerization interface 3.5A [polypeptide binding]; other site 531844005425 active site 531844005426 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 531844005427 active site 531844005428 metal binding site [ion binding]; metal-binding site 531844005429 homotetramer interface [polypeptide binding]; other site 531844005430 exopolyphosphatase; Region: exo_poly_only; TIGR03706 531844005431 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 531844005432 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 531844005433 active site 531844005434 catalytic motif [active] 531844005435 Zn binding site [ion binding]; other site 531844005436 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 531844005437 dimerization interface [polypeptide binding]; other site 531844005438 metal binding site [ion binding]; metal-binding site 531844005439 hydroperoxidase II; Provisional; Region: katE; PRK11249 531844005440 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 531844005441 tetramer interface [polypeptide binding]; other site 531844005442 heme binding pocket [chemical binding]; other site 531844005443 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 531844005444 domain interactions; other site 531844005445 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 531844005446 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 531844005447 active site 531844005448 FMN binding site [chemical binding]; other site 531844005449 substrate binding site [chemical binding]; other site 531844005450 homotetramer interface [polypeptide binding]; other site 531844005451 catalytic residue [active] 531844005452 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 531844005453 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 531844005454 inhibitor-cofactor binding pocket; inhibition site 531844005455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844005456 catalytic residue [active] 531844005457 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 531844005458 LysM domain; Region: LysM; pfam01476 531844005459 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 531844005460 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 531844005461 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 531844005462 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 531844005463 catalytic residue [active] 531844005464 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 531844005465 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 531844005466 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 531844005467 Uncharacterized conserved protein [Function unknown]; Region: COG3379 531844005468 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 531844005469 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 531844005470 NAD binding site [chemical binding]; other site 531844005471 catalytic Zn binding site [ion binding]; other site 531844005472 structural Zn binding site [ion binding]; other site 531844005473 malate dehydrogenase; Reviewed; Region: PRK06223 531844005474 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 531844005475 dimer interface [polypeptide binding]; other site 531844005476 NAD(P) binding site [chemical binding]; other site 531844005477 tetramer (dimer of dimers) interface [polypeptide binding]; other site 531844005478 substrate binding site [chemical binding]; other site 531844005479 serine O-acetyltransferase; Region: cysE; TIGR01172 531844005480 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 531844005481 trimer interface [polypeptide binding]; other site 531844005482 active site 531844005483 substrate binding site [chemical binding]; other site 531844005484 CoA binding site [chemical binding]; other site 531844005485 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 531844005486 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 531844005487 dimer interface [polypeptide binding]; other site 531844005488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844005489 catalytic residue [active] 531844005490 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 531844005491 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974 531844005492 putative DNA binding site [nucleotide binding]; other site 531844005493 catalytic residue [active] 531844005494 putative H2TH interface [polypeptide binding]; other site 531844005495 putative catalytic residues [active] 531844005496 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 531844005497 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 531844005498 heme binding pocket [chemical binding]; other site 531844005499 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 531844005500 heme binding pocket [chemical binding]; other site 531844005501 heme ligand [chemical binding]; other site 531844005502 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 531844005503 GAF domain; Region: GAF; pfam01590 531844005504 Phytochrome region; Region: PHY; pfam00360 531844005505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844005506 dimer interface [polypeptide binding]; other site 531844005507 phosphorylation site [posttranslational modification] 531844005508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844005509 ATP binding site [chemical binding]; other site 531844005510 Mg2+ binding site [ion binding]; other site 531844005511 G-X-G motif; other site 531844005512 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 531844005513 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 531844005514 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 531844005515 nucleotide binding site [chemical binding]; other site 531844005516 NEF interaction site [polypeptide binding]; other site 531844005517 SBD interface [polypeptide binding]; other site 531844005518 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844005519 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 531844005520 Cytochrome c; Region: Cytochrom_C; cl11414 531844005521 Cytochrome c; Region: Cytochrom_C; pfam00034 531844005522 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 531844005523 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 531844005524 NosL; Region: NosL; cl01769 531844005525 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 531844005526 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 531844005527 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 531844005528 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 531844005529 Walker A/P-loop; other site 531844005530 ATP binding site [chemical binding]; other site 531844005531 Q-loop/lid; other site 531844005532 ABC transporter signature motif; other site 531844005533 Walker B; other site 531844005534 D-loop; other site 531844005535 H-loop/switch region; other site 531844005536 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 531844005537 Fasciclin domain; Region: Fasciclin; pfam02469 531844005538 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 531844005539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 531844005540 ligand binding site [chemical binding]; other site 531844005541 flexible hinge region; other site 531844005542 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 531844005543 putative switch regulator; other site 531844005544 non-specific DNA interactions [nucleotide binding]; other site 531844005545 DNA binding site [nucleotide binding] 531844005546 sequence specific DNA binding site [nucleotide binding]; other site 531844005547 putative cAMP binding site [chemical binding]; other site 531844005548 polyphosphate kinase; Provisional; Region: PRK05443 531844005549 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 531844005550 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 531844005551 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 531844005552 domain interface [polypeptide binding]; other site 531844005553 active site 531844005554 catalytic site [active] 531844005555 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 531844005556 putative active site [active] 531844005557 catalytic site [active] 531844005558 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 531844005559 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 531844005560 N-terminal plug; other site 531844005561 ligand-binding site [chemical binding]; other site 531844005562 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 531844005563 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 531844005564 active site 531844005565 NTP binding site [chemical binding]; other site 531844005566 metal binding triad [ion binding]; metal-binding site 531844005567 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 531844005568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 531844005569 Zn2+ binding site [ion binding]; other site 531844005570 Mg2+ binding site [ion binding]; other site 531844005571 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 531844005572 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 531844005573 Peptidase family M23; Region: Peptidase_M23; pfam01551 531844005574 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005575 Predicted membrane protein [Function unknown]; Region: COG2246 531844005576 GtrA-like protein; Region: GtrA; pfam04138 531844005577 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 531844005578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 531844005579 putative acyl-acceptor binding pocket; other site 531844005580 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 531844005581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844005582 putative substrate translocation pore; other site 531844005583 L-fucose transporter; Provisional; Region: PRK10133; cl17665 531844005584 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 531844005585 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 531844005586 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 531844005587 catalytic residues [active] 531844005588 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005589 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 531844005590 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 531844005591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844005592 Walker A motif; other site 531844005593 ATP binding site [chemical binding]; other site 531844005594 Walker B motif; other site 531844005595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 531844005596 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 531844005597 nucleotide binding site/active site [active] 531844005598 HIT family signature motif; other site 531844005599 catalytic residue [active] 531844005600 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 531844005601 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 531844005602 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 531844005603 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 531844005604 putative active site [active] 531844005605 dimerization interface [polypeptide binding]; other site 531844005606 putative tRNAtyr binding site [nucleotide binding]; other site 531844005607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 531844005608 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 531844005609 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 531844005610 DHH family; Region: DHH; pfam01368 531844005611 DHHA1 domain; Region: DHHA1; pfam02272 531844005612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 531844005613 dimerization interface [polypeptide binding]; other site 531844005614 putative DNA binding site [nucleotide binding]; other site 531844005615 putative Zn2+ binding site [ion binding]; other site 531844005616 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 531844005617 arsenical-resistance protein; Region: acr3; TIGR00832 531844005618 Low molecular weight phosphatase family; Region: LMWPc; cl00105 531844005619 active site 531844005620 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 531844005621 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 531844005622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 531844005623 Walker A/P-loop; other site 531844005624 ATP binding site [chemical binding]; other site 531844005625 Q-loop/lid; other site 531844005626 ABC transporter signature motif; other site 531844005627 Walker B; other site 531844005628 D-loop; other site 531844005629 H-loop/switch region; other site 531844005630 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 531844005631 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 531844005632 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 531844005633 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 531844005634 HIGH motif; other site 531844005635 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 531844005636 active site 531844005637 KMSKS motif; other site 531844005638 Cupin domain; Region: Cupin_2; cl17218 531844005639 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 531844005640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844005641 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 531844005642 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 531844005643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 531844005644 inhibitor-cofactor binding pocket; inhibition site 531844005645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844005646 catalytic residue [active] 531844005647 thiosulfate reductase PhsA; Provisional; Region: PRK15488 531844005648 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 531844005649 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 531844005650 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 531844005651 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 531844005652 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 531844005653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 531844005654 carboxyltransferase (CT) interaction site; other site 531844005655 biotinylation site [posttranslational modification]; other site 531844005656 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 531844005657 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 531844005658 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 531844005659 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 531844005660 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 531844005661 Lumazine binding domain; Region: Lum_binding; pfam00677 531844005662 Lumazine binding domain; Region: Lum_binding; pfam00677 531844005663 HAMP domain; Region: HAMP; pfam00672 531844005664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 531844005665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844005666 dimer interface [polypeptide binding]; other site 531844005667 phosphorylation site [posttranslational modification] 531844005668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844005669 ATP binding site [chemical binding]; other site 531844005670 Mg2+ binding site [ion binding]; other site 531844005671 G-X-G motif; other site 531844005672 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 531844005673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844005674 S-adenosylmethionine binding site [chemical binding]; other site 531844005675 elongation factor Ts; Provisional; Region: tsf; PRK09377 531844005676 UBA/TS-N domain; Region: UBA; pfam00627 531844005677 Elongation factor TS; Region: EF_TS; pfam00889 531844005678 Elongation factor TS; Region: EF_TS; pfam00889 531844005679 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 531844005680 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 531844005681 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 531844005682 putative active site [active] 531844005683 substrate binding site [chemical binding]; other site 531844005684 putative cosubstrate binding site; other site 531844005685 catalytic site [active] 531844005686 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 531844005687 substrate binding site [chemical binding]; other site 531844005688 DEAD-like helicases superfamily; Region: DEXDc; smart00487 531844005689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844005690 ATP binding site [chemical binding]; other site 531844005691 putative Mg++ binding site [ion binding]; other site 531844005692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844005693 nucleotide binding region [chemical binding]; other site 531844005694 ATP-binding site [chemical binding]; other site 531844005695 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 531844005696 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 531844005697 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 531844005698 ligand binding site [chemical binding]; other site 531844005699 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 531844005700 tandem repeat interface [polypeptide binding]; other site 531844005701 oligomer interface [polypeptide binding]; other site 531844005702 active site residues [active] 531844005703 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 531844005704 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 531844005705 tandem repeat interface [polypeptide binding]; other site 531844005706 oligomer interface [polypeptide binding]; other site 531844005707 active site residues [active] 531844005708 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 531844005709 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 531844005710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 531844005711 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 531844005712 ribosomal protein L33; Region: rpl33; CHL00104 531844005713 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 531844005714 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 531844005715 FAD binding domain; Region: FAD_binding_4; pfam01565 531844005716 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 531844005717 aspartate aminotransferase; Provisional; Region: PRK07568 531844005718 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 531844005719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 531844005720 homodimer interface [polypeptide binding]; other site 531844005721 catalytic residue [active] 531844005722 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 531844005723 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 531844005724 active site 531844005725 Zn binding site [ion binding]; other site 531844005726 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 531844005727 Repair protein; Region: Repair_PSII; pfam04536 531844005728 Repair protein; Region: Repair_PSII; cl01535 531844005729 LemA family; Region: LemA; cl00742 531844005730 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 531844005731 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 531844005732 folate binding site [chemical binding]; other site 531844005733 NADP+ binding site [chemical binding]; other site 531844005734 UPF0126 domain; Region: UPF0126; pfam03458 531844005735 Predicted membrane protein [Function unknown]; Region: COG2860 531844005736 UPF0126 domain; Region: UPF0126; pfam03458 531844005737 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 531844005738 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 531844005739 active site 531844005740 (T/H)XGH motif; other site 531844005741 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 531844005742 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 531844005743 ATP-grasp domain; Region: ATP-grasp_4; cl17255 531844005744 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 531844005745 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 531844005746 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 531844005747 putative metal binding site [ion binding]; other site 531844005748 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 531844005749 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 531844005750 active site 531844005751 DNA polymerase IV; Validated; Region: PRK02406 531844005752 DNA binding site [nucleotide binding] 531844005753 Helix-turn-helix domain; Region: HTH_18; pfam12833 531844005754 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 531844005755 proposed catalytic triad [active] 531844005756 active site nucleophile [active] 531844005757 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 531844005758 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 531844005759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 531844005760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844005761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844005762 YceI-like domain; Region: YceI; pfam04264 531844005763 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 531844005764 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 531844005765 active site 531844005766 Na/Ca binding site [ion binding]; other site 531844005767 catalytic site [active] 531844005768 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 531844005769 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 531844005770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844005771 FeS/SAM binding site; other site 531844005772 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 531844005773 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 531844005774 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 531844005775 putative NAD(P) binding site [chemical binding]; other site 531844005776 putative substrate binding site [chemical binding]; other site 531844005777 catalytic Zn binding site [ion binding]; other site 531844005778 structural Zn binding site [ion binding]; other site 531844005779 dimer interface [polypeptide binding]; other site 531844005780 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 531844005781 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 531844005782 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 531844005783 CoA-binding site [chemical binding]; other site 531844005784 ATP-binding [chemical binding]; other site 531844005785 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 531844005786 GxxExxY protein; Region: GxxExxY; TIGR04256 531844005787 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 531844005788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844005789 binding surface 531844005790 TPR motif; other site 531844005791 TPR repeat; Region: TPR_11; pfam13414 531844005792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844005793 binding surface 531844005794 TPR motif; other site 531844005795 Tetratricopeptide repeat; Region: TPR_9; pfam13371 531844005796 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 531844005797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844005798 Walker A motif; other site 531844005799 ATP binding site [chemical binding]; other site 531844005800 Walker B motif; other site 531844005801 arginine finger; other site 531844005802 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 531844005803 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 531844005804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844005805 putative substrate translocation pore; other site 531844005806 imidazolonepropionase; Validated; Region: PRK09356 531844005807 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 531844005808 active site 531844005809 Family of unknown function (DUF695); Region: DUF695; pfam05117 531844005810 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 531844005811 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 531844005812 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 531844005813 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 531844005814 enoyl-CoA hydratase; Provisional; Region: PRK08140 531844005815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 531844005816 substrate binding site [chemical binding]; other site 531844005817 oxyanion hole (OAH) forming residues; other site 531844005818 trimer interface [polypeptide binding]; other site 531844005819 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 531844005820 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 531844005821 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 531844005822 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 531844005823 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 531844005824 CoenzymeA binding site [chemical binding]; other site 531844005825 subunit interaction site [polypeptide binding]; other site 531844005826 PHB binding site; other site 531844005827 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 531844005828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844005829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 531844005830 DNA binding residues [nucleotide binding] 531844005831 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 531844005832 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 531844005833 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 531844005834 Beta-lactamase; Region: Beta-lactamase; pfam00144 531844005835 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 531844005836 potential frameshift: common BLAST hit: gi|120434847|ref|YP_860533.1| methylmalonyl-CoA mutase-like protein 531844005837 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 531844005838 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 531844005839 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 531844005840 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 531844005841 B12 binding site [chemical binding]; other site 531844005842 cobalt ligand [ion binding]; other site 531844005843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 531844005844 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 531844005845 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 531844005846 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 531844005847 active site 531844005848 metal binding site [ion binding]; metal-binding site 531844005849 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 531844005850 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 531844005851 homotrimer interaction site [polypeptide binding]; other site 531844005852 putative active site [active] 531844005853 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 531844005854 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 531844005855 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 531844005856 protein binding site [polypeptide binding]; other site 531844005857 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 531844005858 protein binding site [polypeptide binding]; other site 531844005859 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 531844005860 Amidinotransferase; Region: Amidinotransf; cl12043 531844005861 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 531844005862 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 531844005863 Amidinotransferase; Region: Amidinotransf; pfam02274 531844005864 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 531844005865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844005866 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 531844005867 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 531844005868 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 531844005869 active site 531844005870 (T/H)XGH motif; other site 531844005871 Surface antigen; Region: Bac_surface_Ag; pfam01103 531844005872 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 531844005873 classical (c) SDRs; Region: SDR_c; cd05233 531844005874 NAD(P) binding site [chemical binding]; other site 531844005875 active site 531844005876 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 531844005877 Malic enzyme, N-terminal domain; Region: malic; pfam00390 531844005878 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 531844005879 putative NAD(P) binding site [chemical binding]; other site 531844005880 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 531844005881 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 531844005882 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 531844005883 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 531844005884 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 531844005885 Walker A motif; other site 531844005886 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 531844005887 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 531844005888 Bacterial SH3 domain; Region: SH3_3; pfam08239 531844005889 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 531844005890 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 531844005891 Predicted acyl esterases [General function prediction only]; Region: COG2936 531844005892 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 531844005893 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 531844005894 putative active site [active] 531844005895 Mn binding site [ion binding]; other site 531844005896 Predicted membrane protein [General function prediction only]; Region: COG4194 531844005897 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 531844005898 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 531844005899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 531844005900 motif II; other site 531844005901 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 531844005902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 531844005903 dimer interface [polypeptide binding]; other site 531844005904 active site 531844005905 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 531844005906 catalytic residues [active] 531844005907 substrate binding site [chemical binding]; other site 531844005908 Thiamine pyrophosphokinase; Region: TPK; cd07995 531844005909 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 531844005910 active site 531844005911 dimerization interface [polypeptide binding]; other site 531844005912 thiamine binding site [chemical binding]; other site 531844005913 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 531844005914 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 531844005915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844005916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 531844005917 DNA binding residues [nucleotide binding] 531844005918 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 531844005919 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 531844005920 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 531844005921 substrate binding site [chemical binding]; other site 531844005922 dimer interface [polypeptide binding]; other site 531844005923 ATP binding site [chemical binding]; other site 531844005924 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 531844005925 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 531844005926 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 531844005927 active site 531844005928 HIGH motif; other site 531844005929 nucleotide binding site [chemical binding]; other site 531844005930 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 531844005931 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 531844005932 active site 531844005933 KMSKS motif; other site 531844005934 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 531844005935 tRNA binding surface [nucleotide binding]; other site 531844005936 anticodon binding site; other site 531844005937 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 531844005938 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 531844005939 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 531844005940 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 531844005941 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 531844005942 CoA-ligase; Region: Ligase_CoA; pfam00549 531844005943 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 531844005944 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 531844005945 homodimer interface [polypeptide binding]; other site 531844005946 catalytic residues [active] 531844005947 NAD binding site [chemical binding]; other site 531844005948 substrate binding pocket [chemical binding]; other site 531844005949 flexible flap; other site 531844005950 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 531844005951 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 531844005952 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 531844005953 ABC transporter; Region: ABC_tran_2; pfam12848 531844005954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 531844005955 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 531844005956 putative catalytic site [active] 531844005957 putative metal binding site [ion binding]; other site 531844005958 putative phosphate binding site [ion binding]; other site 531844005959 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 531844005960 Clp amino terminal domain; Region: Clp_N; pfam02861 531844005961 Clp amino terminal domain; Region: Clp_N; pfam02861 531844005962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844005963 Walker A motif; other site 531844005964 ATP binding site [chemical binding]; other site 531844005965 Walker B motif; other site 531844005966 arginine finger; other site 531844005967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844005968 Walker A motif; other site 531844005969 ATP binding site [chemical binding]; other site 531844005970 Walker B motif; other site 531844005971 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 531844005972 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 531844005973 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 531844005974 FAD binding pocket [chemical binding]; other site 531844005975 FAD binding motif [chemical binding]; other site 531844005976 phosphate binding motif [ion binding]; other site 531844005977 beta-alpha-beta structure motif; other site 531844005978 NAD(p) ribose binding residues [chemical binding]; other site 531844005979 NAD binding pocket [chemical binding]; other site 531844005980 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 531844005981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 531844005982 catalytic loop [active] 531844005983 iron binding site [ion binding]; other site 531844005984 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 531844005985 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 531844005986 formimidoylglutamase; Provisional; Region: PRK13775 531844005987 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 531844005988 putative active site [active] 531844005989 putative metal binding site [ion binding]; other site 531844005990 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844005991 acyl carrier protein; Provisional; Region: acpP; PRK00982 531844005992 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 531844005993 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 531844005994 dimer interface [polypeptide binding]; other site 531844005995 active site 531844005996 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 531844005997 dimerization interface [polypeptide binding]; other site 531844005998 active site 531844005999 metal binding site [ion binding]; metal-binding site 531844006000 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 531844006001 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 531844006002 domain interfaces; other site 531844006003 active site 531844006004 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 531844006005 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 531844006006 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 531844006007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 531844006008 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 531844006009 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844006010 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 531844006011 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 531844006012 active site 531844006013 substrate-binding site [chemical binding]; other site 531844006014 metal-binding site [ion binding] 531844006015 ATP binding site [chemical binding]; other site 531844006016 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 531844006017 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 531844006018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 531844006019 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 531844006020 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 531844006021 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 531844006022 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 531844006023 ligand binding site [chemical binding]; other site 531844006024 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 531844006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 531844006026 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 531844006027 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 531844006028 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844006029 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844006030 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844006031 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844006032 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844006033 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844006034 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 531844006035 starch binding outer membrane protein SusD; Region: SusD; cd08977 531844006036 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 531844006037 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844006038 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 531844006039 translation initiation factor IF-2; Region: IF-2; TIGR00487 531844006040 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 531844006041 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 531844006042 G1 box; other site 531844006043 putative GEF interaction site [polypeptide binding]; other site 531844006044 GTP/Mg2+ binding site [chemical binding]; other site 531844006045 Switch I region; other site 531844006046 G2 box; other site 531844006047 G3 box; other site 531844006048 Switch II region; other site 531844006049 G4 box; other site 531844006050 G5 box; other site 531844006051 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 531844006052 Translation-initiation factor 2; Region: IF-2; pfam11987 531844006053 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 531844006054 transcription termination factor NusA; Region: NusA; TIGR01953 531844006055 NusA N-terminal domain; Region: NusA_N; pfam08529 531844006056 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 531844006057 RNA binding site [nucleotide binding]; other site 531844006058 homodimer interface [polypeptide binding]; other site 531844006059 NusA-like KH domain; Region: KH_5; pfam13184 531844006060 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 531844006061 G-X-X-G motif; other site 531844006062 ribosome maturation protein RimP; Reviewed; Region: PRK00092 531844006063 Sm and related proteins; Region: Sm_like; cl00259 531844006064 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 531844006065 putative oligomer interface [polypeptide binding]; other site 531844006066 putative RNA binding site [nucleotide binding]; other site 531844006067 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 531844006068 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 531844006069 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 531844006070 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 531844006071 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 531844006072 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 531844006073 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 531844006074 Walker A/P-loop; other site 531844006075 ATP binding site [chemical binding]; other site 531844006076 Q-loop/lid; other site 531844006077 ABC transporter signature motif; other site 531844006078 Walker B; other site 531844006079 D-loop; other site 531844006080 H-loop/switch region; other site 531844006081 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 531844006082 putative carbohydrate binding site [chemical binding]; other site 531844006083 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 531844006084 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844006085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844006086 active site 531844006087 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 531844006088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844006089 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844006090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844006091 active site 531844006092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844006093 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 531844006094 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844006095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844006096 active site 531844006097 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 531844006098 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 531844006099 Ligand binding site; other site 531844006100 metal-binding site 531844006101 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 531844006102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 531844006103 active site 531844006104 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 531844006105 trimer interface [polypeptide binding]; other site 531844006106 active site 531844006107 substrate binding site [chemical binding]; other site 531844006108 CoA binding site [chemical binding]; other site 531844006109 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 531844006110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844006111 active site 531844006112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844006113 active site 531844006114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844006115 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 531844006116 putative ADP-binding pocket [chemical binding]; other site 531844006117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844006118 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 531844006119 putative ADP-binding pocket [chemical binding]; other site 531844006120 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 531844006121 trimer interface [polypeptide binding]; other site 531844006122 active site 531844006123 substrate binding site [chemical binding]; other site 531844006124 CoA binding site [chemical binding]; other site 531844006125 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 531844006126 active site clefts [active] 531844006127 zinc binding site [ion binding]; other site 531844006128 dimer interface [polypeptide binding]; other site 531844006129 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 531844006130 Sulfate transporter family; Region: Sulfate_transp; pfam00916 531844006131 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 531844006132 active site clefts [active] 531844006133 zinc binding site [ion binding]; other site 531844006134 dimer interface [polypeptide binding]; other site 531844006135 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 531844006136 putative active site [active] 531844006137 catalytic residue [active] 531844006138 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 531844006139 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 531844006140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844006141 ATP binding site [chemical binding]; other site 531844006142 putative Mg++ binding site [ion binding]; other site 531844006143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844006144 nucleotide binding region [chemical binding]; other site 531844006145 ATP-binding site [chemical binding]; other site 531844006146 TRCF domain; Region: TRCF; pfam03461 531844006147 GH3 auxin-responsive promoter; Region: GH3; pfam03321 531844006148 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 531844006149 enterobactin exporter EntS; Provisional; Region: PRK10489 531844006150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 531844006151 putative substrate translocation pore; other site 531844006152 replicative DNA helicase; Region: DnaB; TIGR00665 531844006153 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 531844006154 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 531844006155 Walker A motif; other site 531844006156 ATP binding site [chemical binding]; other site 531844006157 Walker B motif; other site 531844006158 DNA binding loops [nucleotide binding] 531844006159 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 531844006160 RNA/DNA hybrid binding site [nucleotide binding]; other site 531844006161 active site 531844006162 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 531844006163 dimer interface [polypeptide binding]; other site 531844006164 FMN binding site [chemical binding]; other site 531844006165 L-aspartate oxidase; Provisional; Region: PRK06175 531844006166 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 531844006167 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 531844006168 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 531844006169 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 531844006170 active site residue [active] 531844006171 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 531844006172 active site residue [active] 531844006173 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 531844006174 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 531844006175 dimerization interface [polypeptide binding]; other site 531844006176 active site 531844006177 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 531844006178 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844006179 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 531844006180 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 531844006181 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 531844006182 Cation efflux family; Region: Cation_efflux; pfam01545 531844006183 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 531844006184 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 531844006185 Phosphotransferase enzyme family; Region: APH; pfam01636 531844006186 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 531844006187 GxxExxY protein; Region: GxxExxY; TIGR04256 531844006188 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 531844006189 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 531844006190 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 531844006191 Substrate binding site; other site 531844006192 metal-binding site 531844006193 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 531844006194 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 531844006195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844006196 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 531844006197 putative catalytic site [active] 531844006198 putative metal binding site [ion binding]; other site 531844006199 putative phosphate binding site [ion binding]; other site 531844006200 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 531844006201 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 531844006202 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 531844006203 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 531844006204 transcription termination factor Rho; Provisional; Region: PRK12608 531844006205 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 531844006206 RNA binding site [nucleotide binding]; other site 531844006207 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 531844006208 multimer interface [polypeptide binding]; other site 531844006209 Walker A motif; other site 531844006210 ATP binding site [chemical binding]; other site 531844006211 Walker B motif; other site 531844006212 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 531844006213 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 531844006214 Peptidase family M28; Region: Peptidase_M28; pfam04389 531844006215 metal binding site [ion binding]; metal-binding site 531844006216 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 531844006217 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 531844006218 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 531844006219 Walker A/P-loop; other site 531844006220 ATP binding site [chemical binding]; other site 531844006221 Q-loop/lid; other site 531844006222 ABC transporter signature motif; other site 531844006223 Walker B; other site 531844006224 D-loop; other site 531844006225 H-loop/switch region; other site 531844006226 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 531844006227 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 531844006228 MutS domain I; Region: MutS_I; pfam01624 531844006229 MutS domain II; Region: MutS_II; pfam05188 531844006230 MutS domain III; Region: MutS_III; pfam05192 531844006231 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 531844006232 Walker A/P-loop; other site 531844006233 ATP binding site [chemical binding]; other site 531844006234 Q-loop/lid; other site 531844006235 ABC transporter signature motif; other site 531844006236 Walker B; other site 531844006237 D-loop; other site 531844006238 H-loop/switch region; other site 531844006239 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 531844006240 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 531844006241 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 531844006242 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 531844006243 Glutamate binding site [chemical binding]; other site 531844006244 NAD binding site [chemical binding]; other site 531844006245 catalytic residues [active] 531844006246 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 531844006247 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 531844006248 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 531844006249 FeoA domain; Region: FeoA; pfam04023 531844006250 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 531844006251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 531844006252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 531844006253 catalytic residue [active] 531844006254 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 531844006255 Peptidase family M28; Region: Peptidase_M28; pfam04389 531844006256 putative metal binding site [ion binding]; other site 531844006257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844006258 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 531844006259 NAD(P) binding site [chemical binding]; other site 531844006260 active site 531844006261 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 531844006262 uridine phosphorylase; Provisional; Region: PRK11178 531844006263 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 531844006264 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 531844006265 putative rRNA binding site [nucleotide binding]; other site 531844006266 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 531844006267 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 531844006268 HlyD family secretion protein; Region: HlyD_3; pfam13437 531844006269 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 531844006270 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 531844006271 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 531844006272 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 531844006273 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 531844006274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 531844006275 active site 531844006276 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 531844006277 homopentamer interface [polypeptide binding]; other site 531844006278 active site 531844006279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844006280 active site 531844006281 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 531844006282 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 531844006283 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 531844006284 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 531844006285 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 531844006286 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 531844006287 molybdopterin cofactor binding site; other site 531844006288 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 531844006289 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 531844006290 4Fe-4S binding domain; Region: Fer4; cl02805 531844006291 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 531844006292 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 531844006293 Cytochrome c; Region: Cytochrom_C; pfam00034 531844006294 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 531844006295 heme-binding residues [chemical binding]; other site 531844006296 Sporulation related domain; Region: SPOR; cl10051 531844006297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 531844006298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844006299 active site 531844006300 phosphorylation site [posttranslational modification] 531844006301 intermolecular recognition site; other site 531844006302 dimerization interface [polypeptide binding]; other site 531844006303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 531844006304 DNA binding site [nucleotide binding] 531844006305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 531844006306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 531844006307 dimer interface [polypeptide binding]; other site 531844006308 phosphorylation site [posttranslational modification] 531844006309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844006310 ATP binding site [chemical binding]; other site 531844006311 Mg2+ binding site [ion binding]; other site 531844006312 G-X-G motif; other site 531844006313 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 531844006314 putative hydrophobic ligand binding site [chemical binding]; other site 531844006315 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 531844006316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844006317 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 531844006318 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 531844006319 active site 531844006320 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 531844006321 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 531844006322 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 531844006323 Ligand binding site; other site 531844006324 Putative Catalytic site; other site 531844006325 DXD motif; other site 531844006326 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 531844006327 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 531844006328 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 531844006329 Predicted permeases [General function prediction only]; Region: COG0795 531844006330 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 531844006331 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 531844006332 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 531844006333 Oligomerisation domain; Region: Oligomerisation; pfam02410 531844006334 FtsH Extracellular; Region: FtsH_ext; pfam06480 531844006335 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 531844006336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844006337 Walker A motif; other site 531844006338 ATP binding site [chemical binding]; other site 531844006339 Walker B motif; other site 531844006340 arginine finger; other site 531844006341 Peptidase family M41; Region: Peptidase_M41; pfam01434 531844006342 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 531844006343 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 531844006344 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 531844006345 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 531844006346 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 531844006347 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 531844006348 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 531844006349 Ligand Binding Site [chemical binding]; other site 531844006350 flavoprotein, HI0933 family; Region: TIGR00275 531844006351 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 531844006352 active site 531844006353 thiamine-monophosphate kinase; Region: thiL; TIGR01379 531844006354 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 531844006355 ATP binding site [chemical binding]; other site 531844006356 dimerization interface [polypeptide binding]; other site 531844006357 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 531844006358 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 531844006359 Acyltransferase family; Region: Acyl_transf_3; pfam01757 531844006360 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 531844006361 active site 531844006362 dinuclear metal binding site [ion binding]; other site 531844006363 dimerization interface [polypeptide binding]; other site 531844006364 Protein of unknown function (DUF502); Region: DUF502; cl01107 531844006365 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 531844006366 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 531844006367 substrate binding site [chemical binding]; other site 531844006368 tetramer interface [polypeptide binding]; other site 531844006369 catalytic residue [active] 531844006370 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 531844006371 elongation factor G; Reviewed; Region: PRK12740 531844006372 G1 box; other site 531844006373 putative GEF interaction site [polypeptide binding]; other site 531844006374 GTP/Mg2+ binding site [chemical binding]; other site 531844006375 Switch I region; other site 531844006376 G2 box; other site 531844006377 G3 box; other site 531844006378 Switch II region; other site 531844006379 G4 box; other site 531844006380 G5 box; other site 531844006381 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 531844006382 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 531844006383 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 531844006384 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 531844006385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 531844006386 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 531844006387 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 531844006388 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 531844006389 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 531844006390 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 531844006391 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 531844006392 dimer interface [polypeptide binding]; other site 531844006393 tetramer interface [polypeptide binding]; other site 531844006394 PYR/PP interface [polypeptide binding]; other site 531844006395 TPP binding site [chemical binding]; other site 531844006396 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 531844006397 TPP-binding site; other site 531844006398 GH3 auxin-responsive promoter; Region: GH3; pfam03321 531844006399 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 531844006400 Yqey-like protein; Region: YqeY; pfam09424 531844006401 cell division protein FtsZ; Validated; Region: PRK09330 531844006402 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 531844006403 nucleotide binding site [chemical binding]; other site 531844006404 SulA interaction site; other site 531844006405 cell division protein FtsA; Region: ftsA; TIGR01174 531844006406 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 531844006407 nucleotide binding site [chemical binding]; other site 531844006408 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 531844006409 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 531844006410 Cell division protein FtsA; Region: FtsA; pfam14450 531844006411 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 531844006412 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 531844006413 NAD binding site [chemical binding]; other site 531844006414 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844006415 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844006416 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 531844006417 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 531844006418 active site 531844006419 homodimer interface [polypeptide binding]; other site 531844006420 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 531844006421 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 531844006422 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 531844006423 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844006424 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844006425 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 531844006426 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 531844006427 Mg++ binding site [ion binding]; other site 531844006428 putative catalytic motif [active] 531844006429 putative substrate binding site [chemical binding]; other site 531844006430 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 531844006431 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 531844006432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844006433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844006434 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 531844006435 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 531844006436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 531844006437 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 531844006438 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 531844006439 MraW methylase family; Region: Methyltransf_5; cl17771 531844006440 cell division protein MraZ; Reviewed; Region: PRK00326 531844006441 MraZ protein; Region: MraZ; pfam02381 531844006442 MraZ protein; Region: MraZ; pfam02381 531844006443 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 531844006444 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 531844006445 G1 box; other site 531844006446 GTP/Mg2+ binding site [chemical binding]; other site 531844006447 Switch I region; other site 531844006448 G2 box; other site 531844006449 G3 box; other site 531844006450 Switch II region; other site 531844006451 G4 box; other site 531844006452 G5 box; other site 531844006453 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 531844006454 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 531844006455 Radical SAM superfamily; Region: Radical_SAM; pfam04055 531844006456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 531844006457 FeS/SAM binding site; other site 531844006458 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 531844006459 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 531844006460 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 531844006461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 531844006462 ATP binding site [chemical binding]; other site 531844006463 Mg2+ binding site [ion binding]; other site 531844006464 G-X-G motif; other site 531844006465 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 531844006466 ATP binding site [chemical binding]; other site 531844006467 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 531844006468 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 531844006469 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 531844006470 putative catalytic site [active] 531844006471 putative metal binding site [ion binding]; other site 531844006472 putative phosphate binding site [ion binding]; other site 531844006473 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 531844006474 para-aminobenzoate synthase component I; Validated; Region: PRK07093 531844006475 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 531844006476 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 531844006477 excinuclease ABC subunit B; Provisional; Region: PRK05298 531844006478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 531844006479 ATP binding site [chemical binding]; other site 531844006480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 531844006481 nucleotide binding region [chemical binding]; other site 531844006482 ATP-binding site [chemical binding]; other site 531844006483 Ultra-violet resistance protein B; Region: UvrB; pfam12344 531844006484 UvrB/uvrC motif; Region: UVR; pfam02151 531844006485 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 531844006486 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 531844006487 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 531844006488 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 531844006489 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 531844006490 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 531844006491 active site 531844006492 intersubunit interface [polypeptide binding]; other site 531844006493 zinc binding site [ion binding]; other site 531844006494 Na+ binding site [ion binding]; other site 531844006495 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 531844006496 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 531844006497 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 531844006498 EamA-like transporter family; Region: EamA; pfam00892 531844006499 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 531844006500 EamA-like transporter family; Region: EamA; pfam00892 531844006501 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 531844006502 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 531844006503 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 531844006504 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 531844006505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 531844006506 NAD(P) binding site [chemical binding]; other site 531844006507 active site 531844006508 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 531844006509 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 531844006510 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 531844006511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 531844006512 nucleotide binding region [chemical binding]; other site 531844006513 ATP-binding site [chemical binding]; other site 531844006514 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 531844006515 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 531844006516 nucleotide binding site [chemical binding]; other site 531844006517 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 531844006518 Repair protein; Region: Repair_PSII; pfam04536 531844006519 methionine sulfoxide reductase A; Provisional; Region: PRK14054 531844006520 Peptidase S46; Region: Peptidase_S46; pfam10459 531844006521 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 531844006522 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 531844006523 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 531844006524 Asp-box motif; other site 531844006525 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 531844006526 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 531844006527 SprT homologues; Region: SprT; cl01182 531844006528 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 531844006529 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 531844006530 Substrate binding site; other site 531844006531 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 531844006532 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 531844006533 putative active site [active] 531844006534 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 531844006535 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 531844006536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 531844006537 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 531844006538 Clp amino terminal domain; Region: Clp_N; pfam02861 531844006539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844006540 Walker A motif; other site 531844006541 ATP binding site [chemical binding]; other site 531844006542 Walker B motif; other site 531844006543 arginine finger; other site 531844006544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 531844006545 Walker A motif; other site 531844006546 ATP binding site [chemical binding]; other site 531844006547 Walker B motif; other site 531844006548 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 531844006549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844006550 TPR motif; other site 531844006551 binding surface 531844006552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844006553 binding surface 531844006554 Tetratricopeptide repeat; Region: TPR_16; pfam13432 531844006555 TPR motif; other site 531844006556 TPR repeat; Region: TPR_11; pfam13414 531844006557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 531844006558 binding surface 531844006559 TPR motif; other site 531844006560 TPR repeat; Region: TPR_11; pfam13414 531844006561 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 531844006562 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 531844006563 active site 531844006564 substrate binding site [chemical binding]; other site 531844006565 metal binding site [ion binding]; metal-binding site 531844006566 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 531844006567 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 531844006568 G1 box; other site 531844006569 GTP/Mg2+ binding site [chemical binding]; other site 531844006570 Switch I region; other site 531844006571 G2 box; other site 531844006572 G3 box; other site 531844006573 Switch II region; other site 531844006574 G4 box; other site 531844006575 G5 box; other site 531844006576 Nucleoside recognition; Region: Gate; pfam07670 531844006577 Nucleoside recognition; Region: Gate; pfam07670 531844006578 FeoA domain; Region: FeoA; pfam04023 531844006579 GLPGLI family protein; Region: GLPGLI; TIGR01200 531844006580 DinB family; Region: DinB; cl17821 531844006581 DinB superfamily; Region: DinB_2; pfam12867 531844006582 GLPGLI family protein; Region: GLPGLI; TIGR01200 531844006583 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 531844006584 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 531844006585 Cupin-like domain; Region: Cupin_8; pfam13621 531844006586 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 531844006587 putative active site [active] 531844006588 Zn binding site [ion binding]; other site 531844006589 GTP-binding protein LepA; Provisional; Region: PRK05433 531844006590 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 531844006591 G1 box; other site 531844006592 putative GEF interaction site [polypeptide binding]; other site 531844006593 GTP/Mg2+ binding site [chemical binding]; other site 531844006594 Switch I region; other site 531844006595 G2 box; other site 531844006596 G3 box; other site 531844006597 Switch II region; other site 531844006598 G4 box; other site 531844006599 G5 box; other site 531844006600 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 531844006601 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 531844006602 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 531844006603 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 531844006604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 531844006605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 531844006606 DNA binding residues [nucleotide binding] 531844006607 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 531844006608 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 531844006609 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 531844006610 Maf-like protein; Region: Maf; pfam02545 531844006611 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 531844006612 active site 531844006613 dimer interface [polypeptide binding]; other site 531844006614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 531844006615 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 531844006616 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 531844006617 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 531844006618 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 531844006619 5S rRNA interface [nucleotide binding]; other site 531844006620 CTC domain interface [polypeptide binding]; other site 531844006621 L16 interface [polypeptide binding]; other site 531844006622 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 531844006623 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 531844006624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 531844006625 active site 531844006626 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 531844006627 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 531844006628 catalytic triad [active] 531844006629 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 531844006630 PSP1 C-terminal conserved region; Region: PSP1; cl00770 531844006631 GldH lipoprotein; Region: GldH_lipo; pfam14109 531844006632 Transglycosylase; Region: Transgly; pfam00912 531844006633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 531844006634 Uncharacterized conserved protein [Function unknown]; Region: COG0397 531844006635 hypothetical protein; Validated; Region: PRK00029 531844006636 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 531844006637 E-class dimer interface [polypeptide binding]; other site 531844006638 P-class dimer interface [polypeptide binding]; other site 531844006639 active site 531844006640 Cu2+ binding site [ion binding]; other site 531844006641 Zn2+ binding site [ion binding]; other site 531844006642 Cna protein B-type domain; Region: Cna_B_2; pfam13715 531844006643 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 531844006644 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 531844006645 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 531844006646 Domain of unknown function (DUF336); Region: DUF336; pfam03928 531844006647 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 531844006648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 531844006649 active site 531844006650 phosphorylation site [posttranslational modification] 531844006651 intermolecular recognition site; other site 531844006652 dimerization interface [polypeptide binding]; other site 531844006653 LytTr DNA-binding domain; Region: LytTR; smart00850 531844006654 2TM domain; Region: 2TM; pfam13239 531844006655 2TM domain; Region: 2TM; pfam13239 531844006656 Histidine kinase; Region: His_kinase; pfam06580 531844006657 2TM domain; Region: 2TM; pfam13239 531844006658 C-terminal peptidase (prc); Region: prc; TIGR00225 531844006659 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 531844006660 protein binding site [polypeptide binding]; other site 531844006661 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 531844006662 Catalytic dyad [active] 531844006663 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 531844006664 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 531844006665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 531844006666 Zn2+ binding site [ion binding]; other site 531844006667 Mg2+ binding site [ion binding]; other site 531844006668 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 531844006669 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 531844006670 active site 531844006671 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 531844006672 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 531844006673 NAD(P) binding site [chemical binding]; other site 531844006674 homotetramer interface [polypeptide binding]; other site 531844006675 homodimer interface [polypeptide binding]; other site 531844006676 active site 531844006677 Predicted methyltransferases [General function prediction only]; Region: COG0313 531844006678 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 531844006679 putative SAM binding site [chemical binding]; other site 531844006680 putative homodimer interface [polypeptide binding]; other site 531844006681 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 531844006682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 531844006683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844006684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 531844006685 thymidine kinase; Provisional; Region: PRK04296 531844006686 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 531844006687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 531844006688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 531844006689 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 531844006690 active site 531844006691 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 531844006692 dimer interface [polypeptide binding]; other site 531844006693 substrate binding site [chemical binding]; other site 531844006694 catalytic residues [active] 531844006695 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 531844006696 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 531844006697 active site 531844006698 nucleophile elbow; other site 531844006699 Surface antigen; Region: Bac_surface_Ag; pfam01103 531844006700 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 531844006701 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 531844006702 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 531844006703 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 531844006704 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 531844006705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 531844006706 S-adenosylmethionine binding site [chemical binding]; other site 531844006707 Phosphoglycerate kinase; Region: PGK; pfam00162 531844006708 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 531844006709 substrate binding site [chemical binding]; other site 531844006710 hinge regions; other site 531844006711 ADP binding site [chemical binding]; other site 531844006712 catalytic site [active]